                         SEQUENCE LISTING

<110>  The Macfarlane Burnet Institute for Medical Research and 
       Public Health Ltd
       Genmab A/S
 
<120>  MODIFIED IMMUNOGLOBULIN WITH AFFINITY FOR FcGAMMARIIb AND METHOD 
       OF USE THEREOF

<130>  55982PCT

<150>  AU2020904823
<151>  2020-12-23

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  1

Glu Leu Leu Gly Gly 
1               5   


<210>  2
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant lower hinge sequence derived from human IgG4

<400>  2

Glu Phe Leu Gly Gly 
1               5   


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant lower hinge sequence

<400>  3

Glu Phe Glu Gly Gly 
1               5   


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lower hinge sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be proline (P) or glutamic acid (E)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be valine (V), leucine (L) or phenylalanine (F)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa can be leucine (L), alanine (A) or glutamic acid (E)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be glycine (G) or proline (P)

<400>  4

Xaa Xaa Xaa Gly Xaa 
1               5   


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lower hinge sequence

<400>  5

Glu Phe Leu Gly Pro 
1               5   


<210>  6
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant lower hinge sequence

<400>  6

Phe Leu Gly Gly 
1               


<210>  7
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant lower hinge sequence

<400>  7

Leu Leu Gly Gly 
1               


<210>  8
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant lower hinge sequence

<400>  8

Phe Glu Gly Gly 
1               


<210>  9
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  9

Cys Pro Pro Cys 
1               


<210>  10
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  10

Pro Glu Leu Leu Gly Gly 
1               5       


<210>  11
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  11

Pro Pro Val Ala Gly 
1               5   


<210>  12
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FEGG lower hinge sequence

<400>  12

Pro Glu Phe Glu Gly Gly 
1               5       


<210>  13
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  13

Pro Glu Phe Leu Gly Gly 
1               5       


<210>  14
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  14

Pro Val Ala Gly 
1               


<210>  15
<211>  1398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TNP mAb formatted as IgG2-FEGG-SELF variant

<400>  15
aagcttacca tggtgcttag tttgctgtat ctgctcaccg ccctgcctgg aatcctgagc       60

gaggtgcagt tgcaggaatc tggtcccagt ctagttaagc ccagccagac actgagcctg      120

acatgtagtg tgaccggtga cagcattaca agcggctact ggaactggat cagacaggtg      180

ccaggaaaca aactcgaata catggggttc atcaattaca gtggcaatac ttactataat      240

cccagcctga gaagcagaat ttctataacc agagacacca gcaaaaacca gtactttctg      300

cacctgaaca gcgtaacaac ggaagacacc gccacctatt actgcgccag ggccaactgg      360

gatgtgttcg catactgggg ccagggcact ctggtgacgg tgagcgccgc gtcgacaaaa      420

ggccctagcg tctttccact cgccccatgt tcaagaagca ccagcgagtc aactgcggct      480

ttgggctgct tggtgaagga ttacttccca gagcctgtca ctgtcagctg gaatagcggg      540

gctctgacca gtggagtgca cacctttccc gccgtgttac agagcagcgg cctctatagc      600

ctgagcagtg tggtaactgt gccctcgagc aattttggta cccagaccta tacatgcaat      660

gtcgatcata aacccagtaa cacaaaggta gacaagacag tcgaaagaaa atgctgtgtg      720

gagtgccctc cttgccccgc ccccgagttt gagggggggc cttcggtttt tctttttcca      780

cctaaaccga aagacaccct gatgatcagc aggacaccag aagtgacatg tgtcgtcgtg      840

gacgtagagc atgaagaccc ggaggtgcaa ttcaactggt atgttgatgg tgtggaagtg      900

cataatgcaa aaactaagcc acgggaggaa cagttcaata gcacattcag agtagttagc      960

gttctgactg tcgtgcacca agattggctg aacgggaagg aatacaagtg taaggtgagc     1020

aacaaaggtt ttcccgctcc aattgagaaa acaatttcta agaccaaagg acagccccgg     1080

gagccacagg tgtatactct gccgcctagc agggaggaaa tgaccaagaa ccaggtgagc     1140

ctgacctgtc tggtgaaagg cttctacccc agcgatatcg cagttgagtg ggagagcaat     1200

ggccaacccg agaacaacta caagactacg ccccccatgc ttgatagcga cggatcattt     1260

ttcctgtact caaaactgac cgtggacaaa agcagatggc agcagggaaa cgttttcagt     1320

tgctcagtga tgcacgaagc gctgcacaat cattatactc agaaaagcct gagcttgagc     1380

ttaggaaaat gatctaga                                                   1398


<210>  16
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-TNP mAb formatted as IgG2-FEGG-SELF variant

<400>  16

Met Val Leu Ser Leu Leu Tyr Leu Leu Thr Ala Leu Pro Gly Ile Leu 
1               5                   10                  15      


Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser 
            20                  25                  30          


Gln Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser 
        35                  40                  45              


Gly Tyr Trp Asn Trp Ile Arg Gln Val Pro Gly Asn Lys Leu Glu Tyr 
    50                  55                  60                  


Met Gly Phe Ile Asn Tyr Ser Gly Asn Thr Tyr Tyr Asn Pro Ser Leu 
65                  70                  75                  80  


Arg Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Phe 
                85                  90                  95      


Leu His Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Ala Arg Ala Asn Trp Asp Val Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn 
        195                 200                 205             


Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro 
225                 230                 235                 240 


Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe 
                245                 250                 255     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            260                 265                 270         


Thr Cys Val Val Val Asp Val Glu His Glu Asp Pro Glu Val Gln Phe 
        275                 280                 285             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    290                 295                 300                 


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
305                 310                 315                 320 


Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                325                 330                 335     


Ser Asn Lys Gly Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
            340                 345                 350         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        355                 360                 365             


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    370                 375                 380                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
385                 390                 395                 400 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
                405                 410                 415     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            420                 425                 430         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        435                 440                 445             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    450                 455                 460 


<210>  17
<211>  1398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TNP mAb formatted as IgG2-FLGG-SELF variant

<400>  17
aagcttacca tggtgcttag tttgctgtat ctgctcaccg ccctgcctgg aatcctgagc       60

gaggtgcagt tgcaggaatc tggtcccagt ctagttaagc ccagccagac actgagcctg      120

acatgtagtg tgaccggtga cagcattaca agcggctact ggaactggat cagacaggtg      180

ccaggaaaca aactcgaata catggggttc atcaattaca gtggcaatac ttactataat      240

cccagcctga gaagcagaat ttctataacc agagacacca gcaaaaacca gtactttctg      300

cacctgaaca gcgtaacaac ggaagacacc gccacctatt actgcgccag ggccaactgg      360

gatgtgttcg catactgggg ccagggcact ctggtgacgg tgagcgccgc gtcgacaaaa      420

ggccctagcg tctttccact cgccccatgt tcaagaagca ccagcgagtc aactgcggct      480

ttgggctgct tggtgaagga ttacttccca gagcctgtca ctgtcagctg gaatagcggg      540

gctctgacca gtggagtgca cacctttccc gccgtgttac agagcagcgg cctctatagc      600

ctgagcagtg tggtaactgt gccctcgagc aattttggta cccagaccta tacatgcaat      660

gtcgatcata aacccagtaa cacaaaggta gacaagacag tcgaaagaaa atgctgtgtg      720

gagtgccctc cttgccccgc ccccgagttt ctgggggggc cttcggtttt tctttttcca      780

cctaaaccga aagacaccct gatgatcagc aggacaccag aagtgacatg tgtcgtcgtg      840

gacgtagagc atgaagaccc ggaggtgcaa ttcaactggt atgttgatgg tgtggaagtg      900

cataatgcaa aaactaagcc acgggaggaa cagttcaata gcacattcag agtagttagc      960

gttctgactg tcgtgcacca agattggctg aacgggaagg aatacaagtg taaggtgagc     1020

aacaaaggtt ttcccgctcc aattgagaaa acaatttcta agaccaaagg acagccccgg     1080

gagccacagg tgtatactct gccgcctagc agggaggaaa tgaccaagaa ccaggtgagc     1140

ctgacctgtc tggtgaaagg cttctacccc agcgatatcg cagttgagtg ggagagcaat     1200

ggccaacccg agaacaacta caagactacg ccccccatgc ttgatagcga cggatcattt     1260

ttcctgtact caaaactgac cgtggacaaa agcagatggc agcagggaaa cgttttcagt     1320

tgctcagtga tgcacgaagc gctgcacaat cattatactc agaaaagcct gagcttgagc     1380

ttaggaaaat gatctaga                                                   1398


<210>  18
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-TNP mAb formatted as IgG2-FLGG-SELF variant

<400>  18

Lys Leu Thr Met Val Leu Ser Leu Leu Tyr Leu Leu Thr Ala Leu Pro 
1               5                   10                  15      


Gly Ile Leu Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val 
            20                  25                  30          


Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser 
        35                  40                  45              


Ile Thr Ser Gly Tyr Trp Asn Trp Ile Arg Gln Val Pro Gly Asn Lys 
    50                  55                  60                  


Leu Glu Tyr Met Gly Phe Ile Asn Tyr Ser Gly Asn Thr Tyr Tyr Asn 
65                  70                  75                  80  


Pro Ser Leu Arg Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn 
                85                  90                  95      


Gln Tyr Phe Leu His Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ala Asn Trp Asp Val Phe Ala Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val 
    130                 135                 140                 


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             


Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys 
    210                 215                 220                 


Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val 
225                 230                 235                 240 


Glu Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Glu His Glu Asp Pro Glu 
        275                 280                 285             


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Gly Phe Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    450                 455                 460             


<210>  19
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric anti-TNP light chain

<400>  19
atggattccc aggcccaggt gctcatgctg ttactcctgt gggtctccgg aacctgcggc       60

gacatagtga tgtcacagag cccaagcagc cttgcagtgt ctgttggtga gaaggtgacc      120

atgagctgca agtcaagcca gagcctgctc tatagcagca atcagaagaa ctatttggcc      180

tggtatcaga gaaaacccgg ccagagccct aagctcctta tttattgggc tagcacacgc      240

gagtccggcg tgccggacag atttaccggc agcggtagcg gcaccgattt tactttgacc      300

atctcgtctg taaaggccga agacctggca gtgtattact gtcaacatta ttactcatct      360

ccctacactt tcggaggggg gaccaaactg gaaattaagc gtacggttgc tgccccttct      420

gtcttcatct tccctcccag cgatgaacag ctgaaaagtg ggacagcgag tgtagtgtgc      480

ctgctaaaca atttttaccc acgggaggcc aaagtgcagt ggaaagtgga caacgctctg      540

caaagtggaa attctcagga gtccgtcaca gagcaggact cgaaggacag cacttacagc      600

ttgtcaagca ccctgacgct gagcaaagcc gattacgaga agcacaaggt gtacgcatgc      660

gaagttacgc accaaggact gagtagccca gtcacaaaga gcttcaacag gggggaatgt      720

tag                                                                    723


<210>  20
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric anti-TNP light chain

<400>  20

Met Asp Ser Gln Ala Gln Val Leu Met Leu Leu Leu Leu Trp Val Ser 
1               5                   10                  15      


Gly Thr Cys Gly Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala 
            20                  25                  30          


Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Arg 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln His Tyr Tyr Ser Ser Pro Tyr Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  21
<211>  1404
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-IgE formatted as IgG4

<400>  21
atgggctggt cctgcatcat cctgtttctg gtggccacag ccaccggcgt gcactctgaa       60

gtgcagctgg tggaatctgg cggcggactg gtgcagcctg gcggatctct gagactgagc      120

tgtgccgtgt ccggctacag catcaccagc ggctactctt ggaactggat ccggcaggcc      180

cctggcaagg gactggaatg ggtggcctcc atcacctacg acggcagcac caactacaac      240

cccagcgtga agggccggat caccatcagc agggacgaca gcaagaacac attctacctg      300

caaatgaaca gcctgcgggc cgaggacacc gccgtgtact attgtgccag aggcagccac      360

tacttcggcc actggcactt tgccgtgtgg ggccagggaa caacggtcac cgtgtctgca      420

gcgtcgacaa aaggtcccag cgtgtttccc ctggctcctt gtagcagaag cacgtcagaa      480

agtacagctg ccctgggatg cctggtgaaa gattattttc ccgagcccgt taccgtttcc      540

tggaatagtg gcgccctgac ctcgggcgtg catacttttc ccgctgttct gcagagcagc      600

ggcctgtata gcctgagcag tgtggtgact gttccgtcta gcagcctggg taccaagact      660

tatacatgca acgtggacca taagcctagc aatactaagg tagataagcg agtggagagc      720

aagtacggcc ccccctgccc tagctgtccc gcacctgagt ttctaggcgg gcccagcgtg      780

tttctgttcc ccccgaagcc taaagatacc ctgatgatca gcagaacacc cgaagtgacc      840

tgcgtggttg tggacgtcag ccaggaagat cctgaggtgc agttcaattg gtacgtggac      900

ggcgtggagg tgcacaatgc taagacaaag ccccgcgaag agcaattcaa cagcacatat      960

agagtagtat ctgtgctgac cgtgctgcac caggattggc tgaacggcaa ggaatacaaa     1020

tgtaaagtga gcaacaaggg cttacccagt agcatcgaga agaccattag caaagcaaaa     1080

ggtcaacccc gggagcccca ggtgtacacc ctgcctccga gccaagagga aatgacaaag     1140

aatcaggtga gcctgacctg cctggtgaag ggattttacc ccagcgatat tgctgtggag     1200

tgggagagca atgggcaacc agagaataac tacaaaacga ccccaccagt attagactcg     1260

gacggatctt tcttcttgta ttcgcggctg actgtggaca agagcagatg gcaagagggc     1320

aatgttttca gctgtagcgt tatgcacgaa gcgctgcaca atcattatac tcagaaaagc     1380

ctgagcttga gcttaggaaa atga                                            1404


<210>  22
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-IgE formatted as IgG4

<400>  22

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Gly Tyr Ser Trp Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Ser Ile Thr Tyr Asp Gly Ser Thr Asn Tyr Asn 
65                  70                  75                  80  


Pro Ser Val Lys Gly Arg Ile Thr Ile Ser Arg Asp Asp Ser Lys Asn 
                85                  90                  95      


Thr Phe Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Ser His Tyr Phe Gly His Trp His Phe Ala 
        115                 120                 125             


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ala Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
145                 150                 155                 160 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn 
    210                 215                 220                 


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser 
225                 230                 235                 240 


Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Leu Gly Lys 
465         


<210>  23
<211>  1401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-IgE formatted as IgG2variant

<400>  23
atgggctggt cctgcatcat cctgtttctg gtggccacag ccaccggcgt gcactctgaa       60

gtgcagctgg tggaatctgg cggcggactg gtgcagcctg gcggatctct gagactgagc      120

tgtgccgtgt ccggctacag catcaccagc ggctactctt ggaactggat ccggcaggcc      180

cctggcaagg gactggaatg ggtggcctcc atcacctacg acggcagcac caactacaac      240

cccagcgtga agggccggat caccatcagc agggacgaca gcaagaacac attctacctg      300

caaatgaaca gcctgcgggc cgaggacacc gccgtgtact attgtgccag aggcagccac      360

tacttcggcc actggcactt tgccgtgtgg ggccagggaa caacggtcac cgtgtctgca      420

gcgtcgacaa aaggccctag cgtctttcca ctcgccccat gttcaagaag caccagcgag      480

tcaactgcgg ctttgggctg cttggtgaag gattacttcc cagagcctgt cactgtcagc      540

tggaatagcg gggctctgac cagtggagtg cacacctttc ccgccgtgtt acagagcagc      600

ggcctctata gcctgagcag tgtggtaact gtgccctcga gcaattttgg tacccagacc      660

tatacatgca atgtcgatca taaacccagt aacacaaagg tagacaagac agtcgaaaga      720

aaatgctgtg tggagtgccc tccttgcccc gcccccccag tggccgggcc ttcggttttt      780

ctttttccac ctaaaccgaa agacaccctg atgatcagca ggacaccaga agtgacatgt      840

gtcgtcgtgg acgtatccca tgaagacccg gaggtgcaat tcaactggta tgttgatggt      900

gtggaagtgc ataatgcaaa aactaagcca cgggaggaac agttcaatag cacattcaga      960

gtagttagcg ttctgactgt cgtgcaccaa gattggctga acgggaagga atacaagtgt     1020

aaggtgagca acaaaggtct gcccgctcca attgagaaaa caatttctaa gaccaaagga     1080

cagccccggg agccacaggt gtatactctg ccgcctagca gggaggaaat gaccaagaac     1140

caggtgagcc tgacctgtct ggtgaaaggc ttctacccca gcgatatcgc agttgagtgg     1200

gagagcaatg gccaacccga gaacaactac aagactacgc cccccatgct tgatagcgac     1260

ggatcatttt tcctgtactc aaaactgacc gtggacaaaa gcagatggca gcagggaaac     1320

gttttcagtt gctcagtgat gcacgaagcg ctgcacaatc attatactca gaaaagcctg     1380

agcttgagct taggaaaatg a                                               1401


<210>  24
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-IgE formatted as IgG2variant

<400>  24

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Gly Tyr Ser Trp Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Ser Ile Thr Tyr Asp Gly Ser Thr Asn Tyr Asn 
65                  70                  75                  80  


Pro Ser Val Lys Gly Arg Ile Thr Ile Ser Arg Asp Asp Ser Lys Asn 
                85                  90                  95      


Thr Phe Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Ser His Tyr Phe Gly His Trp His Phe Ala 
        115                 120                 125             


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ala Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
145                 150                 155                 160 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn 
    210                 215                 220                 


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg 
225                 230                 235                 240 


Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
    450                 455                 460                 


Gly Lys 
465     


<210>  25
<211>  1404
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-IgE formatted as IgG2-FEGG-SELF variant

<400>  25
atgggctggt cctgcatcat cctgtttctg gtggccacag ccaccggcgt gcactctgaa       60

gtgcagctgg tggaatctgg cggcggactg gtgcagcctg gcggatctct gagactgagc      120

tgtgccgtgt ccggctacag catcaccagc ggctactctt ggaactggat ccggcaggcc      180

cctggcaagg gactggaatg ggtggcctcc atcacctacg acggcagcac caactacaac      240

cccagcgtga agggccggat caccatcagc agggacgaca gcaagaacac attctacctg      300

caaatgaaca gcctgcgggc cgaggacacc gccgtgtact attgtgccag aggcagccac      360

tacttcggcc actggcactt tgccgtgtgg ggccagggaa caacggtcac cgtgtctgca      420

gcgtcgacaa aaggccctag cgtctttcca ctcgccccat gttcaagaag caccagcgag      480

tcaactgcgg ctttgggctg cttggtgaag gattacttcc cagagcctgt cactgtcagc      540

tggaatagcg gggctctgac cagtggagtg cacacctttc ccgccgtgtt acagagcagc      600

ggcctctata gcctgagcag tgtggtaact gtgccctcga gcaattttgg tacccagacc      660

tatacatgca atgtcgatca taaacccagt aacacaaagg tagacaagac agtcgaaaga      720

aaatgctgtg tggagtgccc tccttgcccc gcccccgagt ttgagggggg gccttcggtt      780

tttctttttc cacctaaacc gaaagacacc ctgatgatca gcaggacacc agaagtgaca      840

tgtgtcgtcg tggacgtaga gcatgaagac ccggaggtgc aattcaactg gtatgttgat      900

ggtgtggaag tgcataatgc aaaaactaag ccacgggagg aacagttcaa tagcacattc      960

agagtagtta gcgttctgac tgtcgtgcac caagattggc tgaacgggaa ggaatacaag     1020

tgtaaggtga gcaacaaagg ttttcccgct ccaattgaga aaacaatttc taagaccaaa     1080

ggacagcccc gggagccaca ggtgtatact ctgccgccta gcagggagga aatgaccaag     1140

aaccaggtga gcctgacctg tctggtgaaa ggcttctacc ccagcgatat cgcagttgag     1200

tgggagagca atggccaacc cgagaacaac tacaagacta cgccccccat gcttgatagc     1260

gacggatcat ttttcctgta ctcaaaactg accgtggaca aaagcagatg gcagcaggga     1320

aacgttttca gttgctcagt gatgcacgaa gcgctgcaca atcattatac tcagaaaagc     1380

ctgagcttga gcttaggaaa atga                                            1404


<210>  26
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-IgE formatted as IgG2-FEGG-SELF variant

<400>  26

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Gly Tyr Ser Trp Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Ser Ile Thr Tyr Asp Gly Ser Thr Asn Tyr Asn 
65                  70                  75                  80  


Pro Ser Val Lys Gly Arg Ile Thr Ile Ser Arg Asp Asp Ser Lys Asn 
                85                  90                  95      


Thr Phe Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Ser His Tyr Phe Gly His Trp His Phe Ala 
        115                 120                 125             


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ala Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
145                 150                 155                 160 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn 
    210                 215                 220                 


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg 
225                 230                 235                 240 


Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Glu His 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Phe Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Leu Gly Lys 
465         


<210>  27
<211>  1404
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-IgE formatted as IgG2-FLGG-SELF variant

<400>  27
atgggctggt cctgcatcat cctgtttctg gtggccacag ccaccggcgt gcactctgaa       60

gtgcagctgg tggaatctgg cggcggactg gtgcagcctg gcggatctct gagactgagc      120

tgtgccgtgt ccggctacag catcaccagc ggctactctt ggaactggat ccggcaggcc      180

cctggcaagg gactggaatg ggtggcctcc atcacctacg acggcagcac caactacaac      240

cccagcgtga agggccggat caccatcagc agggacgaca gcaagaacac attctacctg      300

caaatgaaca gcctgcgggc cgaggacacc gccgtgtact attgtgccag aggcagccac      360

tacttcggcc actggcactt tgccgtgtgg ggccagggaa caacggtcac cgtgtctgca      420

gcgtcgacaa aaggccctag cgtctttcca ctcgccccat gttcaagaag caccagcgag      480

tcaactgcgg ctttgggctg cttggtgaag gattacttcc cagagcctgt cactgtcagc      540

tggaatagcg gggctctgac cagtggagtg cacacctttc ccgccgtgtt acagagcagc      600

ggcctctata gcctgagcag tgtggtaact gtgccctcga gcaattttgg tacccagacc      660

tatacatgca atgtcgatca taaacccagt aacacaaagg tagacaagac agtcgaaaga      720

aaatgctgtg tggagtgccc tccttgcccc gcccccgagt ttctgggggg gccttcggtt      780

tttctttttc cacctaaacc gaaagacacc ctgatgatca gcaggacacc agaagtgaca      840

tgtgtcgtcg tggacgtaga gcatgaagac ccggaggtgc aattcaactg gtatgttgat      900

ggtgtggaag tgcataatgc aaaaactaag ccacgggagg aacagttcaa tagcacattc      960

agagtagtta gcgttctgac tgtcgtgcac caagattggc tgaacgggaa ggaatacaag     1020

tgtaaggtga gcaacaaagg ttttcccgct ccaattgaga aaacaatttc taagaccaaa     1080

ggacagcccc gggagccaca ggtgtatact ctgccgccta gcagggagga aatgaccaag     1140

aaccaggtga gcctgacctg tctggtgaaa ggcttctacc ccagcgatat cgcagttgag     1200

tgggagagca atggccaacc cgagaacaac tacaagacta cgccccccat gcttgatagc     1260

gacggatcat ttttcctgta ctcaaaactg accgtggaca aaagcagatg gcagcaggga     1320

aacgttttca gttgctcagt gatgcacgaa gcgctgcaca atcattatac tcagaaaagc     1380

ctgagcttga gcttaggaaa atga                                            1404


<210>  28
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-IgE formatted as IgG2-FLGG-SELF variant

<400>  28

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Gly Tyr Ser Trp Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Ser Ile Thr Tyr Asp Gly Ser Thr Asn Tyr Asn 
65                  70                  75                  80  


Pro Ser Val Lys Gly Arg Ile Thr Ile Ser Arg Asp Asp Ser Lys Asn 
                85                  90                  95      


Thr Phe Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Ser His Tyr Phe Gly His Trp His Phe Ala 
        115                 120                 125             


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ala Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
145                 150                 155                 160 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn 
    210                 215                 220                 


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg 
225                 230                 235                 240 


Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Glu His 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Phe Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Leu Gly Lys 
465         


<210>  29
<211>  714
<212>  DNA
<213>  Homo sapiens

<400>  29
atgggctggt cctgcatcat cctgtttctg gtggccacag ccaccggcgt gcacagcgat       60

atccagctga cacagagacc cagcagcctg tctgccagcg tgggcgacag agtgaccatc      120

acctgtagag ccagccagag cgtggactac gacggcgaca gctacatgaa ctggtatcag      180

cagaagcccg gcaaggcccc caagctgctg atctacgccg ccagctacct ggaaagcggc      240

gtgcccagca gattttccgg cagcggctct ggcaccgact tcaccctgac catcagctcc      300

ctgcagcccg aggacttcgc cacctactac tgccagcaga gccacgagga cccctacacc      360

tttggccagg gcaccaaggt ggaaatcaag cggacagtgg ccgctcccag cgtgttcatc      420

ttcccaccta gcgacgagca gctgaagtcc ggcacagcct ctgtcgtgtg cctgctgaac      480

aacttctacc cccgcgaggc caaggtgcag tggaaggtgg acaatgccct gcagagcggc      540

aacagccagg aaagcgtgac cgagcaggac agcaaggact ccacctacag cctgagcagc      600

accctgacac tgagcaaggc cgactacgag aagcacaagg tgtacgcctg cgaagtgacc      660

caccagggcc tgtctagccc cgtgaccaag agcttcaacc ggggcgagtg ctaa            714


<210>  30
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Leu Thr Gln Arg Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val 
        35                  40                  45              


Asp Tyr Asp Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Tyr Leu Glu Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Ser His Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
    130                 135                 140                 


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
145                 150                 155                 160 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
                165                 170                 175     


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
            180                 185                 190         


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
        195                 200                 205             


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
    210                 215                 220                 


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235         


<210>  31
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lower hinge sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be proline (P) or glutamic acid (E)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be valine (V), leucine (L) or phenylalanine (F)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa can be leucine (L), alanine (A) or glutamic acid (E)

<400>  31

Xaa Xaa Xaa Gly 
1               


