                               SEQUENCE LISTING

<110> CULLINAN AMBER CORP.
 
<120> BI-FUNCTIONAL LINEAR FUSION COLLAGEN-LOCALIZED IMMUNOMODULATORY 
      MOLECULES AND METHODS THEREOF

<130> CUA-001WO

<140> PCT/US2021/064224
<141> 2021-12-17

<150> 63/127,995
<151> 2020-12-18

<160> 80    

<170> PatentIn version 3.5

<210> 1
<211> 153
<212> PRT
<213> Homo sapiens

<400> 1
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210> 2
<211> 133
<212> PRT
<213> Homo sapiens

<400> 2
Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210> 3
<211> 169
<212> PRT
<213> Mus musculus

<400> 3
Met Tyr Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu 
1               5                   10                  15      


Leu Val Asn Ser Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala 
            20                  25                  30          


Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu 
        35                  40                  45              


Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn 
    50                  55                  60                  


Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu 
65                  70                  75                  80  


Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu 
                85                  90                  95      


Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe 
            100                 105                 110         


Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val 
        115                 120                 125             


Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp 
    130                 135                 140                 


Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys 
145                 150                 155                 160 


Gln Ser Ile Ile Ser Thr Ser Pro Gln 
                165                 


<210> 4
<211> 149
<212> PRT
<213> Mus musculus

<400> 4
Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala Glu Ala Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu Glu Gln Leu Leu 
            20                  25                  30          


Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn Tyr Arg Asn Leu 
        35                  40                  45              


Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu Pro Lys Gln Ala 
    50                  55                  60                  


Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu Leu Gly Pro Leu 
65                  70                  75                  80  


Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe Gln Leu Glu Asp 
                85                  90                  95      


Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val Val Lys Leu Lys 
            100                 105                 110         


Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp Glu Ser Ala Thr 
        115                 120                 125             


Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys Gln Ser Ile Ile 
    130                 135                 140                 


Ser Thr Ser Pro Gln 
145                 


<210> 5
<211> 327
<212> PRT
<213> Homo sapiens

<400> 5
Met His Pro Gln Gln Leu Val Val Ser Trp Phe Ser Leu Val Leu Leu 
1               5                   10                  15      


Ala Ser Pro Ile Val Ala Ile Trp Glu Leu Glu Lys Asn Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Thr Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Ser Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Ala 
                85                  90                  95      


Leu Ser Arg Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Ala Lys Ser Phe 
        115                 120                 125             


Leu Lys Cys Glu Ala Lys Asp Tyr Ser Gly His Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Ala Ile Ser Thr Asp Leu Lys Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Arg Gly Val Thr Cys Glu Ala Ala Ser Leu Ser 
                165                 170                 175     


Ala Glu Lys Val Ser Val Asp His Arg Glu Tyr Asn Lys Tyr Thr Val 
            180                 185                 190         


Glu Cys Gln Glu Gly Ser Thr Cys Pro Ala Ala Glu Glu Ser Leu Leu 
        195                 200                 205             


Ile Glu Val Val Val Glu Ala Val His Lys Leu Lys Tyr Glu Asn Tyr 
    210                 215                 220                 


Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys 
225                 230                 235                 240 


Asn Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser 
                245                 250                 255     


Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu 
            260                 265                 270         


Thr Phe Cys Val Gln Val Gln Gly Lys Asn Lys Arg Glu Lys Lys Leu 
        275                 280                 285             


Phe Met Asp Gln Thr Ser Ala Lys Val Thr Cys His Lys Asp Ala Asn 
    290                 295                 300                 


Val Arg Val Gln Ala Arg Asp Arg Tyr Tyr Ser Ser Phe Trp Ser Glu 
305                 310                 315                 320 


Trp Ala Ser Val Ser Cys Ser 
                325         


<210> 6
<211> 221
<212> PRT
<213> Homo sapiens

<400> 6
Met Ser Pro Leu Arg Lys Cys Leu Leu Leu Thr Ser Leu Val Leu Leu 
1               5                   10                  15      


Val Ser Cys Ser Leu Ala Arg Asn Leu Pro Arg Ala Ser Pro Ala Pro 
            20                  25                  30          


Val Thr Glu Pro Val Gln Cys Phe Asn His Ser Gln Thr Leu Leu Arg 
        35                  40                  45              


Ala Val Asn Ser Glu Leu His Lys Ala Ile Gln Met Leu Ala Val Tyr 
    50                  55                  60                  


Ser Cys Thr Pro Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys 
65                  70                  75                  80  


Thr Ser Thr Val Lys Ala Cys Val Pro Leu Glu Leu Val Lys Asn Glu 
                85                  90                  95      


Ser Cys Leu Ala Ser Gly His Ile Ser Phe Thr Thr Asn Gly Ser Cys 
            100                 105                 110         


Leu Ala Ser Gly Lys Thr Ser Phe Met Met Ala Leu Cys Leu Asn Ser 
        115                 120                 125             


Ile Tyr Glu Asp Leu Lys Leu Tyr Gln Leu Glu Phe Lys Asn Met Asn 
    130                 135                 140                 


Ala Gln Leu Leu Met Asp Pro Gln Arg Gln Ile Phe Leu Asp Gln Asn 
145                 150                 155                 160 


Met Leu Ser Ala Ile Asp Glu Leu Ile Gln Ala Leu Asn Gly Ser Asp 
                165                 170                 175     


Val Thr Val Pro Gln Lys Leu Ser Leu Glu Glu Pro Asp Phe Tyr Lys 
            180                 185                 190         


Ile Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala 
        195                 200                 205             


Val Thr Ile Asp Arg Val Met Ser Tyr Leu Thr Ser Ser 
    210                 215                 220     


<210> 7
<211> 306
<212> PRT
<213> Homo sapiens

<400> 7
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser 
305     


<210> 8
<211> 197
<212> PRT
<213> Homo sapiens

<400> 8
Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         


Tyr Leu Asn Ala Ser 
        195         


<210> 9
<211> 313
<212> PRT
<213> Mus musculus

<400> 9
Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser 
305                 310             


<210> 10
<211> 193
<212> PRT
<213> Mus musculus

<400> 10
Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg 
1               5                   10                  15      


Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys 
            20                  25                  30          


Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile 
        35                  40                  45              


Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu 
    50                  55                  60                  


His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr 
65                  70                  75                  80  


Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu 
                85                  90                  95      


Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe 
            100                 105                 110         


Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile 
        115                 120                 125             


Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu 
    130                 135                 140                 


Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala 
145                 150                 155                 160 


Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe 
                165                 170                 175     


Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser 
            180                 185                 190         


Ala 
    


<210> 11
<211> 338
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Lumican sequence

<400> 11
Met Ser Leu Ser Ala Phe Thr Leu Phe Leu Ala Leu Ile Gly Gly Thr 
1               5                   10                  15      


Ser Gly Gln Tyr Tyr Asp Tyr Asp Phe Pro Leu Ser Ile Tyr Gly Gln 
            20                  25                  30          


Ser Ser Pro Asn Cys Ala Pro Glu Cys Asn Cys Pro Glu Ser Tyr Pro 
        35                  40                  45              


Ser Ala Met Tyr Cys Asp Glu Leu Lys Leu Lys Ser Val Pro Met Val 
    50                  55                  60                  


Pro Pro Gly Ile Lys Tyr Leu Tyr Leu Arg Asn Asn Gln Ile Asp His 
65                  70                  75                  80  


Ile Asp Glu Lys Ala Phe Glu Asn Val Thr Asp Leu Gln Trp Leu Ile 
                85                  90                  95      


Leu Asp His Asn Leu Leu Glu Asn Ser Lys Ile Lys Gly Arg Val Phe 
            100                 105                 110         


Ser Lys Leu Lys Gln Leu Lys Lys Leu His Ile Asn His Asn Asn Leu 
        115                 120                 125             


Thr Glu Ser Val Gly Pro Leu Pro Lys Ser Leu Glu Asp Leu Gln Leu 
    130                 135                 140                 


Thr His Asn Lys Ile Thr Lys Leu Gly Ser Phe Glu Gly Leu Val Asn 
145                 150                 155                 160 


Leu Thr Phe Ile His Leu Gln His Asn Arg Leu Lys Glu Asp Ala Val 
                165                 170                 175     


Ser Ala Ala Phe Lys Gly Leu Lys Ser Leu Glu Tyr Leu Asp Leu Ser 
            180                 185                 190         


Phe Asn Gln Ile Ala Arg Leu Pro Ser Gly Leu Pro Val Ser Leu Leu 
        195                 200                 205             


Thr Leu Tyr Leu Asp Asn Asn Lys Ile Ser Asn Ile Pro Asp Glu Tyr 
    210                 215                 220                 


Phe Lys Arg Phe Asn Ala Leu Gln Tyr Leu Arg Leu Ser His Asn Glu 
225                 230                 235                 240 


Leu Ala Asp Ser Gly Ile Pro Gly Asn Ser Phe Asn Val Ser Ser Leu 
                245                 250                 255     


Val Glu Leu Asp Leu Ser Tyr Asn Lys Leu Lys Asn Ile Pro Thr Val 
            260                 265                 270         


Asn Glu Asn Leu Glu Asn Tyr Tyr Leu Glu Val Asn Gln Leu Glu Lys 
        275                 280                 285             


Phe Asp Ile Lys Ser Phe Cys Lys Ile Leu Gly Pro Leu Ser Tyr Ser 
    290                 295                 300                 


Lys Ile Lys His Leu Arg Leu Asp Gly Asn Arg Ile Ser Glu Thr Ser 
305                 310                 315                 320 


Leu Pro Pro Asp Met Tyr Glu Cys Leu Arg Val Ala Asn Glu Val Thr 
                325                 330                 335     


Leu Asn 
        


<210> 12
<211> 263
<212> PRT
<213> Mus musculus

<400> 12
Met Ser Leu His Pro Val Ile Leu Leu Val Leu Val Leu Cys Leu Gly 
1               5                   10                  15      


Trp Lys Ile Asn Thr Gln Glu Gly Ser Leu Pro Asp Ile Thr Ile Phe 
            20                  25                  30          


Pro Asn Ser Ser Leu Met Ile Ser Gln Gly Thr Phe Val Thr Val Val 
        35                  40                  45              


Cys Ser Tyr Ser Asp Lys His Asp Leu Tyr Asn Met Val Arg Leu Glu 
    50                  55                  60                  


Lys Asp Gly Ser Thr Phe Met Glu Lys Ser Thr Glu Pro Tyr Lys Thr 
65                  70                  75                  80  


Glu Asp Glu Phe Glu Ile Gly Pro Val Asn Glu Thr Ile Thr Gly His 
                85                  90                  95      


Tyr Ser Cys Ile Tyr Ser Lys Gly Ile Thr Trp Ser Glu Arg Ser Lys 
            100                 105                 110         


Thr Leu Glu Leu Lys Val Ile Lys Glu Asn Val Ile Gln Thr Pro Ala 
        115                 120                 125             


Pro Gly Pro Thr Ser Asp Thr Ser Trp Leu Lys Thr Tyr Ser Ile Tyr 
    130                 135                 140                 


Ile Phe Thr Val Val Ser Val Ile Phe Leu Leu Cys Leu Ser Ala Leu 
145                 150                 155                 160 


Leu Phe Cys Phe Leu Arg His Arg Gln Lys Lys Gln Gly Leu Pro Asn 
                165                 170                 175     


Asn Lys Arg Gln Gln Gln Arg Pro Glu Glu Arg Leu Asn Leu Ala Thr 
            180                 185                 190         


Asn Gly Leu Glu Met Thr Pro Asp Ile Val Ala Asp Asp Arg Leu Pro 
        195                 200                 205             


Glu Asp Arg Trp Thr Glu Thr Trp Thr Pro Val Ala Gly Asp Leu Gln 
    210                 215                 220                 


Glu Val Thr Tyr Ile Gln Leu Asp His His Ser Leu Thr Gln Arg Ala 
225                 230                 235                 240 


Val Gly Ala Val Thr Ser Gln Ser Thr Asp Met Ala Glu Ser Ser Thr 
                245                 250                 255     


Tyr Ala Ala Ile Ile Arg His 
            260             


<210> 13
<211> 287
<212> PRT
<213> Homo sapiens

<400> 13
Met Ser Pro His Pro Thr Ala Leu Leu Gly Leu Val Leu Cys Leu Ala 
1               5                   10                  15      


Gln Thr Ile His Thr Gln Glu Glu Asp Leu Pro Arg Pro Ser Ile Ser 
            20                  25                  30          


Ala Glu Pro Gly Thr Val Ile Pro Leu Gly Ser His Val Thr Phe Val 
        35                  40                  45              


Cys Arg Gly Pro Val Gly Val Gln Thr Phe Arg Leu Glu Arg Glu Ser 
    50                  55                  60                  


Arg Ser Thr Tyr Asn Asp Thr Glu Asp Val Ser Gln Ala Ser Pro Ser 
65                  70                  75                  80  


Glu Ser Glu Ala Arg Phe Arg Ile Asp Ser Val Ser Glu Gly Asn Ala 
                85                  90                  95      


Gly Pro Tyr Arg Cys Ile Tyr Tyr Lys Pro Pro Lys Trp Ser Glu Gln 
            100                 105                 110         


Ser Asp Tyr Leu Glu Leu Leu Val Lys Glu Thr Ser Gly Gly Pro Asp 
        115                 120                 125             


Ser Pro Asp Thr Glu Pro Gly Ser Ser Ala Gly Pro Thr Gln Arg Pro 
    130                 135                 140                 


Ser Asp Asn Ser His Asn Glu His Ala Pro Ala Ser Gln Gly Leu Lys 
145                 150                 155                 160 


Ala Glu His Leu Tyr Ile Leu Ile Gly Val Ser Val Val Phe Leu Phe 
                165                 170                 175     


Cys Leu Leu Leu Leu Val Leu Phe Cys Leu His Arg Gln Asn Gln Ile 
            180                 185                 190         


Lys Gln Gly Pro Pro Arg Ser Lys Asp Glu Glu Gln Lys Pro Gln Gln 
        195                 200                 205             


Arg Pro Asp Leu Ala Val Asp Val Leu Glu Arg Thr Ala Asp Lys Ala 
    210                 215                 220                 


Thr Val Asn Gly Leu Pro Glu Lys Asp Arg Glu Thr Asp Thr Ser Ala 
225                 230                 235                 240 


Leu Ala Ala Gly Ser Ser Gln Glu Val Thr Tyr Ala Gln Leu Asp His 
                245                 250                 255     


Trp Ala Leu Thr Gln Arg Thr Ala Arg Ala Val Ser Pro Gln Ser Thr 
            260                 265                 270         


Lys Pro Met Ala Glu Ser Ile Thr Tyr Ala Ala Val Ala Arg His 
        275                 280                 285         


<210> 14
<211> 144
<212> PRT
<213> Homo sapiens

<400> 14
Gln Glu Glu Asp Leu Pro Arg Pro Ser Ile Ser Ala Glu Pro Gly Thr 
1               5                   10                  15      


Val Ile Pro Leu Gly Ser His Val Thr Phe Val Cys Arg Gly Pro Val 
            20                  25                  30          


Gly Val Gln Thr Phe Arg Leu Glu Arg Glu Ser Arg Ser Thr Tyr Asn 
        35                  40                  45              


Asp Thr Glu Asp Val Ser Gln Ala Ser Pro Ser Glu Ser Glu Ala Arg 
    50                  55                  60                  


Phe Arg Ile Asp Ser Val Ser Glu Gly Asn Ala Gly Pro Tyr Arg Cys 
65                  70                  75                  80  


Ile Tyr Tyr Lys Pro Pro Lys Trp Ser Glu Gln Ser Asp Tyr Leu Glu 
                85                  90                  95      


Leu Leu Val Lys Glu Thr Ser Gly Gly Pro Asp Ser Pro Asp Thr Glu 
            100                 105                 110         


Pro Gly Ser Ser Ala Gly Pro Thr Gln Arg Pro Ser Asp Asn Ser His 
        115                 120                 125             


Asn Glu His Ala Pro Ala Ser Gln Gly Leu Lys Ala Glu His Leu Tyr 
    130                 135                 140                 


<210> 15
<211> 152
<212> PRT
<213> Homo sapiens

<400> 15
Met Ser Pro His Leu Thr Ala Leu Leu Gly Leu Val Leu Cys Leu Ala 
1               5                   10                  15      


Gln Thr Ile His Thr Gln Glu Gly Ala Leu Pro Arg Pro Ser Ile Ser 
            20                  25                  30          


Ala Glu Pro Gly Thr Val Ile Ser Pro Gly Ser His Val Thr Phe Met 
        35                  40                  45              


Cys Arg Gly Pro Val Gly Val Gln Thr Phe Arg Leu Glu Arg Glu Asp 
    50                  55                  60                  


Arg Ala Lys Tyr Lys Asp Ser Tyr Asn Val Phe Arg Leu Gly Pro Ser 
65                  70                  75                  80  


Glu Ser Glu Ala Arg Phe His Ile Asp Ser Val Ser Glu Gly Asn Ala 
                85                  90                  95      


Gly Leu Tyr Arg Cys Leu Tyr Tyr Lys Pro Pro Gly Trp Ser Glu His 
            100                 105                 110         


Ser Asp Phe Leu Glu Leu Leu Val Lys Glu Ser Ser Gly Gly Pro Asp 
        115                 120                 125             


Ser Pro Asp Thr Glu Pro Gly Ser Ser Ala Gly Thr Val Pro Gly Thr 
    130                 135                 140                 


Glu Ala Ser Gly Phe Asp Ala Pro 
145                 150         


<210> 16
<211> 609
<212> PRT
<213> Homo sapiens

<400> 16
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala 
            20                  25                  30          


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
    50                  55                  60                  


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
65                  70                  75                  80  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
                85                  90                  95      


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
            100                 105                 110         


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
        115                 120                 125             


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
    130                 135                 140                 


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
145                 150                 155                 160 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
                165                 170                 175     


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
            180                 185                 190         


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
        195                 200                 205             


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
    210                 215                 220                 


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
225                 230                 235                 240 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
                245                 250                 255     


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
            260                 265                 270         


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
        275                 280                 285             


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
    290                 295                 300                 


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
305                 310                 315                 320 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
                325                 330                 335     


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
            340                 345                 350         


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
        355                 360                 365             


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
    370                 375                 380                 


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
385                 390                 395                 400 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
                405                 410                 415     


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
            420                 425                 430         


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
        435                 440                 445             


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
    450                 455                 460                 


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
465                 470                 475                 480 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
                485                 490                 495     


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
        515                 520                 525             


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
    530                 535                 540                 


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
545                 550                 555                 560 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
                565                 570                 575     


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
        595                 600                 605             


Leu 
    


<210> 17
<211> 746
<212> PRT
<213> Homo sapiens

<400> 17
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys Ala Asp Ala His Lys Ser Glu Val Ala His 
            20                  25                  30          


Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile 
        35                  40                  45              


Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys 
    50                  55                  60                  


Leu Val Asn Glu Val Gly Glu Phe Ala Lys Thr Cys Val Ala Asp Glu 
65                  70                  75                  80  


Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys 
                85                  90                  95      


Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp 
            100                 105                 110         


Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His 
        115                 120                 125             


Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp 
    130                 135                 140                 


Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys 
145                 150                 155                 160 


Tyr Leu Tyr Glu Ile Ala Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu 
                165                 170                 175     


Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln 
            180                 185                 190         


Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg 
        195                 200                 205             


Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser 
    210                 215                 220                 


Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg 
225                 230                 235                 240 


Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu 
                245                 250                 255     


Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu 
            260                 265                 270         


Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu 
        275                 280                 285             


Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro 
    290                 295                 300                 


Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met 
305                 310                 315                 320 


Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp 
                325                 330                 335     


Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe 
            340                 345                 350         


Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Trp Leu Leu Leu 
        355                 360                 365             


Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala 
    370                 375                 380                 


Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro 
385                 390                 395                 400 


Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe 
                405                 410                 415     


Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr 
            420                 425                 430         


Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser 
        435                 440                 445             


Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala 
    450                 455                 460                 


Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Trp Leu Asn Gln Leu 
465                 470                 475                 480 


Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys 
                485                 490                 495     


Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu 
            500                 505                 510         


Val Asp Glu Gly Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr 
        515                 520                 525             


Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys 
    530                 535                 540                 


Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr 
545                 550                 555                 560 


Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu 
                565                 570                 575     


Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly 
            580                 585                 590         


Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly 
        595                 600                 605             


Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
    610                 615                 620                 


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
625                 630                 635                 640 


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
                645                 650                 655     


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
            660                 665                 670         


Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His 
        675                 680                 685             


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
    690                 695                 700                 


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
705                 710                 715                 720 


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser 
                725                 730                 735     


Ile Ile Ser Thr Leu Gly Gly Gly Gly Ser 
            740                 745     


<210> 18
<211> 726
<212> PRT
<213> Homo sapiens

<400> 18
Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly Ser Ala Pro Thr 
            580                 585                 590         


Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu 
        595                 600                 605             


Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys 
    610                 615                 620                 


Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr 
625                 630                 635                 640 


Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu 
                645                 650                 655     


Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg 
            660                 665                 670         


Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser 
        675                 680                 685             


Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val 
    690                 695                 700                 


Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr 
705                 710                 715                 720 


Leu Thr Gly Gly Gly Ser 
                725     


<210> 19
<211> 115
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Lys Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Pro Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210> 20
<211> 197
<212> PRT
<213> Homo sapiens

<400> 20
Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg 
        195         


<210> 21
<211> 196
<212> PRT
<213> Homo sapiens

<400> 21
Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln 
1               5                   10                  15      


Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser 
            20                  25                  30          


Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr 
        35                  40                  45              


Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu 
    50                  55                  60                  


Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln 
65                  70                  75                  80  


Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu 
                85                  90                  95      


Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala 
            100                 105                 110         


Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys 
        115                 120                 125             


Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr 
    130                 135                 140                 


Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Trp Leu Leu Leu Arg Leu 
145                 150                 155                 160 


Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp 
                165                 170                 175     


Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val 
            180                 185                 190         


Glu Glu Pro Gln 
        195     


<210> 22
<211> 200
<212> PRT
<213> Homo sapiens

<400> 22
Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr 
1               5                   10                  15      


Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln 
            20                  25                  30          


Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val 
        35                  40                  45              


Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala 
    50                  55                  60                  


Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu 
65                  70                  75                  80  


Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu 
                85                  90                  95      


Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr 
            100                 105                 110         


Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile 
        115                 120                 125             


Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu 
    130                 135                 140                 


Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys 
145                 150                 155                 160 


Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala 
                165                 170                 175     


Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala 
            180                 185                 190         


Ala Ser Gln Ala Ala Leu Gly Leu 
        195                 200 


<210> 23
<211> 2195
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Ser Gly Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Ser Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro 
                325                 330                 335     


Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp 
            340                 345                 350         


Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala 
        355                 360                 365             


Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu 
    370                 375                 380                 


Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala 
385                 390                 395                 400 


Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln 
                405                 410                 415     


Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp 
            420                 425                 430         


Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln 
        435                 440                 445             


Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala 
    450                 455                 460                 


Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg 
465                 470                 475                 480 


Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys 
                485                 490                 495     


Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn 
            500                 505                 510         


Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Ser Gly Gly Gly Ser Glu 
        515                 520                 525             


Ala His Lys Ser Glu Ile Ala His Arg Tyr Asn Asp Leu Gly Glu Gln 
    530                 535                 540                 


His Phe Lys Gly Leu Val Leu Ile Ala Phe Ser Gln Tyr Leu Gln Lys 
545                 550                 555                 560 


Cys Ser Tyr Asp Glu His Ala Lys Leu Val Gln Glu Val Thr Asp Phe 
                565                 570                 575     


Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Ala Asn Cys Asp Lys Ser 
            580                 585                 590         


Leu His Thr Leu Phe Gly Asp Lys Leu Cys Ala Ile Pro Asn Leu Arg 
        595                 600                 605             


Glu Asn Tyr Gly Glu Leu Ala Asp Cys Cys Thr Lys Gln Glu Pro Glu 
    610                 615                 620                 


Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Ser Leu Pro 
625                 630                 635                 640 


Pro Phe Glu Arg Pro Glu Ala Glu Ala Met Cys Thr Ser Phe Lys Glu 
                645                 650                 655     


Asn Pro Thr Thr Phe Met Gly His Tyr Leu His Glu Val Ala Arg Arg 
            660                 665                 670         


His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Tyr Tyr Ala Glu Gln Tyr 
        675                 680                 685             


Asn Glu Ile Leu Thr Gln Cys Cys Ala Glu Ala Asp Lys Glu Ser Cys 
    690                 695                 700                 


Leu Thr Pro Lys Leu Asp Gly Val Lys Glu Lys Ala Leu Val Ser Ser 
705                 710                 715                 720 


Val Arg Gln Arg Met Lys Cys Ser Ser Met Gln Lys Phe Gly Glu Arg 
                725                 730                 735     


Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Thr Phe Pro Asn 
            740                 745                 750         


Ala Asp Phe Ala Glu Ile Thr Lys Leu Ala Thr Asp Leu Thr Lys Val 
        755                 760                 765             


Asn Lys Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg 
    770                 775                 780                 


Ala Glu Leu Ala Lys Tyr Met Cys Glu Asn Gln Ala Thr Ile Ser Ser 
785                 790                 795                 800 


Lys Leu Gln Thr Cys Cys Asp Lys Pro Leu Leu Lys Lys Ala His Cys 
                805                 810                 815     


Leu Ser Glu Val Glu His Asp Thr Met Pro Ala Asp Leu Pro Ala Ile 
            820                 825                 830         


Ala Ala Asp Phe Val Glu Asp Gln Glu Val Cys Lys Asn Tyr Ala Glu 
        835                 840                 845             


Ala Lys Asp Val Phe Leu Gly Thr Phe Leu Tyr Glu Tyr Ser Arg Arg 
    850                 855                 860                 


His Pro Asp Tyr Ser Val Ser Leu Leu Leu Arg Leu Ala Lys Lys Tyr 
865                 870                 875                 880 


Glu Ala Thr Leu Glu Lys Cys Cys Ala Glu Ala Asn Pro Pro Ala Cys 
                885                 890                 895     


Tyr Gly Thr Val Leu Ala Glu Phe Gln Pro Leu Val Glu Glu Pro Lys 
            900                 905                 910         


Asn Leu Val Lys Thr Asn Cys Asp Leu Tyr Glu Lys Leu Gly Glu Tyr 
        915                 920                 925             


Gly Phe Gln Asn Ala Ile Leu Val Arg Tyr Thr Gln Lys Ala Pro Gln 
    930                 935                 940                 


Val Ser Thr Pro Thr Leu Val Glu Ala Ala Arg Asn Leu Gly Arg Val 
945                 950                 955                 960 


Gly Thr Lys Cys Cys Thr Leu Pro Glu Asp Gln Arg Leu Pro Cys Val 
                965                 970                 975     


Glu Asp Tyr Leu Ser Ala Ile Leu Asn Arg Val Cys Leu Leu His Glu 
            980                 985                 990         


Lys Thr Pro Val Ser Glu His Val  Thr Lys Cys Cys Ser  Gly Ser Leu 
        995                 1000                 1005             


Val Glu  Arg Arg Pro Cys Phe  Ser Ala Leu Thr Val  Asp Glu Thr 
    1010                 1015                 1020             


Tyr Val  Pro Lys Glu Phe Lys  Ala Glu Thr Phe Thr  Phe His Ser 
    1025                 1030                 1035             


Asp Ile  Cys Thr Leu Pro Glu  Lys Glu Lys Gln Ile  Lys Lys Gln 
    1040                 1045                 1050             


Thr Ala  Leu Ala Glu Leu Val  Lys His Lys Pro Lys  Ala Thr Ala 
    1055                 1060                 1065             


Glu Gln  Leu Lys Thr Val Met  Asp Asp Phe Ala Gln  Phe Leu Asp 
    1070                 1075                 1080             


Thr Cys  Cys Lys Ala Ala Asp  Lys Asp Thr Cys Phe  Ser Thr Glu 
    1085                 1090                 1095             


Gly Pro  Asn Leu Val Thr Arg  Cys Lys Asp Ala Leu  Ala Gly Gly 
    1100                 1105                 1110             


Gly Ser  Gly Gly Gly Ser Ser  Gln Tyr Tyr Asp Tyr  Asp Ile Pro 
    1115                 1120                 1125             


Leu Phe  Met Tyr Gly Gln Ile  Ser Pro Asn Cys Ala  Pro Glu Cys 
    1130                 1135                 1140             


Asn Cys  Pro His Ser Tyr Pro  Thr Ala Met Tyr Cys  Asp Asp Leu 
    1145                 1150                 1155             


Lys Leu  Lys Ser Val Pro Met  Val Pro Pro Gly Ile  Lys Tyr Leu 
    1160                 1165                 1170             


Tyr Leu  Arg Asn Asn Gln Ile  Asp His Ile Asp Glu  Lys Ala Phe 
    1175                 1180                 1185             


Glu Asn  Val Thr Asp Leu Gln  Trp Leu Ile Leu Asp  His Asn Leu 
    1190                 1195                 1200             


Leu Glu  Asn Ser Lys Ile Lys  Gly Lys Val Phe Ser  Lys Leu Lys 
    1205                 1210                 1215             


Gln Leu  Lys Lys Leu His Ile  Asn Tyr Asn Asn Leu  Thr Glu Ser 
    1220                 1225                 1230             


Val Gly  Pro Leu Pro Lys Ser  Leu Gln Asp Leu Gln  Leu Thr Asn 
    1235                 1240                 1245             


Asn Lys  Ile Ser Lys Leu Gly  Ser Phe Asp Gly Leu  Val Asn Leu 
    1250                 1255                 1260             


Thr Phe  Ile Tyr Leu Gln His  Asn Gln Leu Lys Glu  Asp Ala Val 
    1265                 1270                 1275             


Ser Ala  Ser Leu Lys Gly Leu  Lys Ser Leu Glu Tyr  Leu Asp Leu 
    1280                 1285                 1290             


Ser Phe  Asn Gln Met Ser Lys  Leu Pro Ala Gly Leu  Pro Thr Ser 
    1295                 1300                 1305             


Leu Leu  Thr Leu Tyr Leu Asp  Asn Asn Lys Ile Ser  Asn Ile Pro 
    1310                 1315                 1320             


Asp Glu  Tyr Phe Lys Arg Phe  Thr Gly Leu Gln Tyr  Leu Arg Leu 
    1325                 1330                 1335             


Ser His  Asn Glu Leu Ala Asp  Ser Gly Val Pro Gly  Asn Ser Phe 
    1340                 1345                 1350             


Asn Ile  Ser Ser Leu Leu Glu  Leu Asp Leu Ser Tyr  Asn Lys Leu 
    1355                 1360                 1365             


Lys Ser  Ile Pro Thr Val Asn  Glu Asn Leu Glu Asn  Tyr Tyr Leu 
    1370                 1375                 1380             


Glu Val  Asn Glu Leu Glu Lys  Phe Asp Val Lys Ser  Phe Cys Lys 
    1385                 1390                 1395             


Ile Leu  Gly Pro Leu Ser Tyr  Ser Lys Ile Lys His  Leu Arg Leu 
    1400                 1405                 1410             


Asp Gly  Asn Pro Leu Thr Gln  Ser Ser Leu Pro Pro  Asp Met Tyr 
    1415                 1420                 1425             


Glu Cys  Leu Arg Val Ala Asn  Glu Ile Thr Val Asn  Gly Gly Gly 
    1430                 1435                 1440             


Ser Gly  Gly Gly Ser Glu Ala  His Lys Ser Glu Ile  Ala His Arg 
    1445                 1450                 1455             


Tyr Asn  Asp Leu Gly Glu Gln  His Phe Lys Gly Leu  Val Leu Ile 
    1460                 1465                 1470             


Ala Phe  Ser Gln Tyr Leu Gln  Lys Cys Ser Tyr Asp  Glu His Ala 
    1475                 1480                 1485             


Lys Leu  Val Gln Glu Val Thr  Asp Phe Ala Lys Thr  Cys Val Ala 
    1490                 1495                 1500             


Asp Glu  Ser Ala Ala Asn Cys  Asp Lys Ser Leu His  Thr Leu Phe 
    1505                 1510                 1515             


Gly Asp  Lys Leu Cys Ala Ile  Pro Asn Leu Arg Glu  Asn Tyr Gly 
    1520                 1525                 1530             


Glu Leu  Ala Asp Cys Cys Thr  Lys Gln Glu Pro Glu  Arg Asn Glu 
    1535                 1540                 1545             


Cys Phe  Leu Gln His Lys Asp  Asp Asn Pro Ser Leu  Pro Pro Phe 
    1550                 1555                 1560             


Glu Arg  Pro Glu Ala Glu Ala  Met Cys Thr Ser Phe  Lys Glu Asn 
    1565                 1570                 1575             


Pro Thr  Thr Phe Met Gly His  Tyr Leu His Glu Val  Ala Arg Arg 
    1580                 1585                 1590             


His Pro  Tyr Phe Tyr Ala Pro  Glu Leu Leu Tyr Tyr  Ala Glu Gln 
    1595                 1600                 1605             


Tyr Asn  Glu Ile Leu Thr Gln  Cys Cys Ala Glu Ala  Asp Lys Glu 
    1610                 1615                 1620             


Ser Cys  Leu Thr Pro Lys Leu  Asp Gly Val Lys Glu  Lys Ala Leu 
    1625                 1630                 1635             


Val Ser  Ser Val Arg Gln Arg  Met Lys Cys Ser Ser  Met Gln Lys 
    1640                 1645                 1650             


Phe Gly  Glu Arg Ala Phe Lys  Ala Trp Ala Val Ala  Arg Leu Ser 
    1655                 1660                 1665             


Gln Thr  Phe Pro Asn Ala Asp  Phe Ala Glu Ile Thr  Lys Leu Ala 
    1670                 1675                 1680             


Thr Asp  Leu Thr Lys Val Asn  Lys Glu Cys Cys His  Gly Asp Leu 
    1685                 1690                 1695             


Leu Glu  Cys Ala Asp Asp Arg  Ala Glu Leu Ala Lys  Tyr Met Cys 
    1700                 1705                 1710             


Glu Asn  Gln Ala Thr Ile Ser  Ser Lys Leu Gln Thr  Cys Cys Asp 
    1715                 1720                 1725             


Lys Pro  Leu Leu Lys Lys Ala  His Cys Leu Ser Glu  Val Glu His 
    1730                 1735                 1740             


Asp Thr  Met Pro Ala Asp Leu  Pro Ala Ile Ala Ala  Asp Phe Val 
    1745                 1750                 1755             


Glu Asp  Gln Glu Val Cys Lys  Asn Tyr Ala Glu Ala  Lys Asp Val 
    1760                 1765                 1770             


Phe Leu  Gly Thr Phe Leu Tyr  Glu Tyr Ser Arg Arg  His Pro Asp 
    1775                 1780                 1785             


Tyr Ser  Val Ser Leu Leu Leu  Arg Leu Ala Lys Lys  Tyr Glu Ala 
    1790                 1795                 1800             


Thr Leu  Glu Lys Cys Cys Ala  Glu Ala Asn Pro Pro  Ala Cys Tyr 
    1805                 1810                 1815             


Gly Thr  Val Leu Ala Glu Phe  Gln Pro Leu Val Glu  Glu Pro Lys 
    1820                 1825                 1830             


Asn Leu  Val Lys Thr Asn Cys  Asp Leu Tyr Glu Lys  Leu Gly Glu 
    1835                 1840                 1845             


Tyr Gly  Phe Gln Asn Ala Ile  Leu Val Arg Tyr Thr  Gln Lys Ala 
    1850                 1855                 1860             


Pro Gln  Val Ser Thr Pro Thr  Leu Val Glu Ala Ala  Arg Asn Leu 
    1865                 1870                 1875             


Gly Arg  Val Gly Thr Lys Cys  Cys Thr Leu Pro Glu  Asp Gln Arg 
    1880                 1885                 1890             


Leu Pro  Cys Val Glu Asp Tyr  Leu Ser Ala Ile Leu  Asn Arg Val 
    1895                 1900                 1905             


Cys Leu  Leu His Glu Lys Thr  Pro Val Ser Glu His  Val Thr Lys 
    1910                 1915                 1920             


Cys Cys  Ser Gly Ser Leu Val  Glu Arg Arg Pro Cys  Phe Ser Ala 
    1925                 1930                 1935             


Leu Thr  Val Asp Glu Thr Tyr  Val Pro Lys Glu Phe  Lys Ala Glu 
    1940                 1945                 1950             


Thr Phe  Thr Phe His Ser Asp  Ile Cys Thr Leu Pro  Glu Lys Glu 
    1955                 1960                 1965             


Lys Gln  Ile Lys Lys Gln Thr  Ala Leu Ala Glu Leu  Val Lys His 
    1970                 1975                 1980             


Lys Pro  Lys Ala Thr Ala Glu  Gln Leu Lys Thr Val  Met Asp Asp 
    1985                 1990                 1995             


Phe Ala  Gln Phe Leu Asp Thr  Cys Cys Lys Ala Ala  Asp Lys Asp 
    2000                 2005                 2010             


Thr Cys  Phe Ser Thr Glu Gly  Pro Asn Leu Val Thr  Arg Cys Lys 
    2015                 2020                 2025             


Asp Ala  Leu Ala Gly Gly Gly  Ser Ala Pro Thr Ser  Ser Ser Thr 
    2030                 2035                 2040             


Ser Ser  Ser Thr Ala Glu Ala  Gln Gln Gln Gln Gln  Gln Gln Gln 
    2045                 2050                 2055             


Gln Gln  Gln Gln His Leu Glu  Gln Leu Leu Met Asp  Leu Gln Glu 
    2060                 2065                 2070             


Leu Leu  Ser Arg Met Glu Asn  Tyr Arg Asn Leu Lys  Leu Pro Arg 
    2075                 2080                 2085             


Met Leu  Thr Phe Lys Phe Tyr  Leu Pro Lys Gln Ala  Thr Glu Leu 
    2090                 2095                 2100             


Lys Asp  Leu Gln Cys Leu Glu  Asp Glu Leu Gly Pro  Leu Arg His 
    2105                 2110                 2115             


Val Leu  Asp Leu Thr Gln Ser  Lys Ser Phe Gln Leu  Glu Asp Ala 
    2120                 2125                 2130             


Glu Asn  Phe Ile Ser Asn Ile  Arg Val Thr Val Val  Lys Leu Lys 
    2135                 2140                 2145             


Gly Ser  Asp Asn Thr Phe Glu  Cys Gln Phe Asp Asp  Glu Ser Ala 
    2150                 2155                 2160             


Thr Val  Val Asp Phe Leu Arg  Arg Trp Ile Ala Phe  Cys Gln Ser 
    2165                 2170                 2175             


Ile Ile  Ser Thr Ser Pro Gln  His His His His His  His His His 
    2180                 2185                 2190             


His His  
    2195 


<210> 24
<211> 1605
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Ser Gly Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Ser Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro 
                325                 330                 335     


Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp 
            340                 345                 350         


Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala 
        355                 360                 365             


Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu 
    370                 375                 380                 


Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala 
385                 390                 395                 400 


Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln 
                405                 410                 415     


Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp 
            420                 425                 430         


Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln 
        435                 440                 445             


Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala 
    450                 455                 460                 


Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg 
465                 470                 475                 480 


Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys 
                485                 490                 495     


Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn 
            500                 505                 510         


Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly Gly Ser Gly Gly Gly 
        515                 520                 525             


Ser Ser Gln Tyr Tyr Asp Tyr Asp Ile Pro Leu Phe Met Tyr Gly Gln 
    530                 535                 540                 


Ile Ser Pro Asn Cys Ala Pro Glu Cys Asn Cys Pro His Ser Tyr Pro 
545                 550                 555                 560 


Thr Ala Met Tyr Cys Asp Asp Leu Lys Leu Lys Ser Val Pro Met Val 
                565                 570                 575     


Pro Pro Gly Ile Lys Tyr Leu Tyr Leu Arg Asn Asn Gln Ile Asp His 
            580                 585                 590         


Ile Asp Glu Lys Ala Phe Glu Asn Val Thr Asp Leu Gln Trp Leu Ile 
        595                 600                 605             


Leu Asp His Asn Leu Leu Glu Asn Ser Lys Ile Lys Gly Lys Val Phe 
    610                 615                 620                 


Ser Lys Leu Lys Gln Leu Lys Lys Leu His Ile Asn Tyr Asn Asn Leu 
625                 630                 635                 640 


Thr Glu Ser Val Gly Pro Leu Pro Lys Ser Leu Gln Asp Leu Gln Leu 
                645                 650                 655     


Thr Asn Asn Lys Ile Ser Lys Leu Gly Ser Phe Asp Gly Leu Val Asn 
            660                 665                 670         


Leu Thr Phe Ile Tyr Leu Gln His Asn Gln Leu Lys Glu Asp Ala Val 
        675                 680                 685             


Ser Ala Ser Leu Lys Gly Leu Lys Ser Leu Glu Tyr Leu Asp Leu Ser 
    690                 695                 700                 


Phe Asn Gln Met Ser Lys Leu Pro Ala Gly Leu Pro Thr Ser Leu Leu 
705                 710                 715                 720 


Thr Leu Tyr Leu Asp Asn Asn Lys Ile Ser Asn Ile Pro Asp Glu Tyr 
                725                 730                 735     


Phe Lys Arg Phe Thr Gly Leu Gln Tyr Leu Arg Leu Ser His Asn Glu 
            740                 745                 750         


Leu Ala Asp Ser Gly Val Pro Gly Asn Ser Phe Asn Ile Ser Ser Leu 
        755                 760                 765             


Leu Glu Leu Asp Leu Ser Tyr Asn Lys Leu Lys Ser Ile Pro Thr Val 
    770                 775                 780                 


Asn Glu Asn Leu Glu Asn Tyr Tyr Leu Glu Val Asn Glu Leu Glu Lys 
785                 790                 795                 800 


Phe Asp Val Lys Ser Phe Cys Lys Ile Leu Gly Pro Leu Ser Tyr Ser 
                805                 810                 815     


Lys Ile Lys His Leu Arg Leu Asp Gly Asn Pro Leu Thr Gln Ser Ser 
            820                 825                 830         


Leu Pro Pro Asp Met Tyr Glu Cys Leu Arg Val Ala Asn Glu Ile Thr 
        835                 840                 845             


Val Asn Gly Gly Gly Ser Gly Gly Gly Ser Glu Ala His Lys Ser Glu 
    850                 855                 860                 


Ile Ala His Arg Tyr Asn Asp Leu Gly Glu Gln His Phe Lys Gly Leu 
865                 870                 875                 880 


Val Leu Ile Ala Phe Ser Gln Tyr Leu Gln Lys Cys Ser Tyr Asp Glu 
                885                 890                 895     


His Ala Lys Leu Val Gln Glu Val Thr Asp Phe Ala Lys Thr Cys Val 
            900                 905                 910         


Ala Asp Glu Ser Ala Ala Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
        915                 920                 925             


Gly Asp Lys Leu Cys Ala Ile Pro Asn Leu Arg Glu Asn Tyr Gly Glu 
    930                 935                 940                 


Leu Ala Asp Cys Cys Thr Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
945                 950                 955                 960 


Leu Gln His Lys Asp Asp Asn Pro Ser Leu Pro Pro Phe Glu Arg Pro 
                965                 970                 975     


Glu Ala Glu Ala Met Cys Thr Ser Phe Lys Glu Asn Pro Thr Thr Phe 
            980                 985                 990         


Met Gly His Tyr Leu His Glu Val  Ala Arg Arg His Pro  Tyr Phe Tyr 
        995                 1000                 1005             


Ala Pro  Glu Leu Leu Tyr Tyr  Ala Glu Gln Tyr Asn  Glu Ile Leu 
    1010                 1015                 1020             


Thr Gln  Cys Cys Ala Glu Ala  Asp Lys Glu Ser Cys  Leu Thr Pro 
    1025                 1030                 1035             


Lys Leu  Asp Gly Val Lys Glu  Lys Ala Leu Val Ser  Ser Val Arg 
    1040                 1045                 1050             


Gln Arg  Met Lys Cys Ser Ser  Met Gln Lys Phe Gly  Glu Arg Ala 
    1055                 1060                 1065             


Phe Lys  Ala Trp Ala Val Ala  Arg Leu Ser Gln Thr  Phe Pro Asn 
    1070                 1075                 1080             


Ala Asp  Phe Ala Glu Ile Thr  Lys Leu Ala Thr Asp  Leu Thr Lys 
    1085                 1090                 1095             


Val Asn  Lys Glu Cys Cys His  Gly Asp Leu Leu Glu  Cys Ala Asp 
    1100                 1105                 1110             


Asp Arg  Ala Glu Leu Ala Lys  Tyr Met Cys Glu Asn  Gln Ala Thr 
    1115                 1120                 1125             


Ile Ser  Ser Lys Leu Gln Thr  Cys Cys Asp Lys Pro  Leu Leu Lys 
    1130                 1135                 1140             


Lys Ala  His Cys Leu Ser Glu  Val Glu His Asp Thr  Met Pro Ala 
    1145                 1150                 1155             


Asp Leu  Pro Ala Ile Ala Ala  Asp Phe Val Glu Asp  Gln Glu Val 
    1160                 1165                 1170             


Cys Lys  Asn Tyr Ala Glu Ala  Lys Asp Val Phe Leu  Gly Thr Phe 
    1175                 1180                 1185             


Leu Tyr  Glu Tyr Ser Arg Arg  His Pro Asp Tyr Ser  Val Ser Leu 
    1190                 1195                 1200             


Leu Leu  Arg Leu Ala Lys Lys  Tyr Glu Ala Thr Leu  Glu Lys Cys 
    1205                 1210                 1215             


Cys Ala  Glu Ala Asn Pro Pro  Ala Cys Tyr Gly Thr  Val Leu Ala 
    1220                 1225                 1230             


Glu Phe  Gln Pro Leu Val Glu  Glu Pro Lys Asn Leu  Val Lys Thr 
    1235                 1240                 1245             


Asn Cys  Asp Leu Tyr Glu Lys  Leu Gly Glu Tyr Gly  Phe Gln Asn 
    1250                 1255                 1260             


Ala Ile  Leu Val Arg Tyr Thr  Gln Lys Ala Pro Gln  Val Ser Thr 
    1265                 1270                 1275             


Pro Thr  Leu Val Glu Ala Ala  Arg Asn Leu Gly Arg  Val Gly Thr 
    1280                 1285                 1290             


Lys Cys  Cys Thr Leu Pro Glu  Asp Gln Arg Leu Pro  Cys Val Glu 
    1295                 1300                 1305             


Asp Tyr  Leu Ser Ala Ile Leu  Asn Arg Val Cys Leu  Leu His Glu 
    1310                 1315                 1320             


Lys Thr  Pro Val Ser Glu His  Val Thr Lys Cys Cys  Ser Gly Ser 
    1325                 1330                 1335             


Leu Val  Glu Arg Arg Pro Cys  Phe Ser Ala Leu Thr  Val Asp Glu 
    1340                 1345                 1350             


Thr Tyr  Val Pro Lys Glu Phe  Lys Ala Glu Thr Phe  Thr Phe His 
    1355                 1360                 1365             


Ser Asp  Ile Cys Thr Leu Pro  Glu Lys Glu Lys Gln  Ile Lys Lys 
    1370                 1375                 1380             


Gln Thr  Ala Leu Ala Glu Leu  Val Lys His Lys Pro  Lys Ala Thr 
    1385                 1390                 1395             


Ala Glu  Gln Leu Lys Thr Val  Met Asp Asp Phe Ala  Gln Phe Leu 
    1400                 1405                 1410             


Asp Thr  Cys Cys Lys Ala Ala  Asp Lys Asp Thr Cys  Phe Ser Thr 
    1415                 1420                 1425             


Glu Gly  Pro Asn Leu Val Thr  Arg Cys Lys Asp Ala  Leu Ala Gly 
    1430                 1435                 1440             


Gly Gly  Ser Ala Pro Thr Ser  Ser Ser Thr Ser Ser  Ser Thr Ala 
    1445                 1450                 1455             


Glu Ala  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln His 
    1460                 1465                 1470             


Leu Glu  Gln Leu Leu Met Asp  Leu Gln Glu Leu Leu  Ser Arg Met 
    1475                 1480                 1485             


Glu Asn  Tyr Arg Asn Leu Lys  Leu Pro Arg Met Leu  Thr Phe Lys 
    1490                 1495                 1500             


Phe Tyr  Leu Pro Lys Gln Ala  Thr Glu Leu Lys Asp  Leu Gln Cys 
    1505                 1510                 1515             


Leu Glu  Asp Glu Leu Gly Pro  Leu Arg His Val Leu  Asp Leu Thr 
    1520                 1525                 1530             


Gln Ser  Lys Ser Phe Gln Leu  Glu Asp Ala Glu Asn  Phe Ile Ser 
    1535                 1540                 1545             


Asn Ile  Arg Val Thr Val Val  Lys Leu Lys Gly Ser  Asp Asn Thr 
    1550                 1555                 1560             


Phe Glu  Cys Gln Phe Asp Asp  Glu Ser Ala Thr Val  Val Asp Phe 
    1565                 1570                 1575             


Leu Arg  Arg Trp Ile Ala Phe  Cys Gln Ser Ile Ile  Ser Thr Ser 
    1580                 1585                 1590             


Pro Gln  His His His His His  His His His His His  
    1595                 1600                 1605 


<210> 25
<211> 1607
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Ser Gly Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Ser Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro 
                325                 330                 335     


Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp 
            340                 345                 350         


Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala 
        355                 360                 365             


Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu 
    370                 375                 380                 


Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala 
385                 390                 395                 400 


Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln 
                405                 410                 415     


Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp 
            420                 425                 430         


Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln 
        435                 440                 445             


Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala 
    450                 455                 460                 


Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg 
465                 470                 475                 480 


Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys 
                485                 490                 495     


Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn 
            500                 505                 510         


Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Ser Gly Gly Gly Ser Glu 
        515                 520                 525             


Ala His Lys Ser Glu Ile Ala His Arg Tyr Asn Asp Leu Gly Glu Gln 
    530                 535                 540                 


His Phe Lys Gly Leu Val Leu Ile Ala Phe Ser Gln Tyr Leu Gln Lys 
545                 550                 555                 560 


Cys Ser Tyr Asp Glu His Ala Lys Leu Val Gln Glu Val Thr Asp Phe 
                565                 570                 575     


Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Ala Asn Cys Asp Lys Ser 
            580                 585                 590         


Leu His Thr Leu Phe Gly Asp Lys Leu Cys Ala Ile Pro Asn Leu Arg 
        595                 600                 605             


Glu Asn Tyr Gly Glu Leu Ala Asp Cys Cys Thr Lys Gln Glu Pro Glu 
    610                 615                 620                 


Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Ser Leu Pro 
625                 630                 635                 640 


Pro Phe Glu Arg Pro Glu Ala Glu Ala Met Cys Thr Ser Phe Lys Glu 
                645                 650                 655     


Asn Pro Thr Thr Phe Met Gly His Tyr Leu His Glu Val Ala Arg Arg 
            660                 665                 670         


His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Tyr Tyr Ala Glu Gln Tyr 
        675                 680                 685             


Asn Glu Ile Leu Thr Gln Cys Cys Ala Glu Ala Asp Lys Glu Ser Cys 
    690                 695                 700                 


Leu Thr Pro Lys Leu Asp Gly Val Lys Glu Lys Ala Leu Val Ser Ser 
705                 710                 715                 720 


Val Arg Gln Arg Met Lys Cys Ser Ser Met Gln Lys Phe Gly Glu Arg 
                725                 730                 735     


Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Thr Phe Pro Asn 
            740                 745                 750         


Ala Asp Phe Ala Glu Ile Thr Lys Leu Ala Thr Asp Leu Thr Lys Val 
        755                 760                 765             


Asn Lys Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg 
    770                 775                 780                 


Ala Glu Leu Ala Lys Tyr Met Cys Glu Asn Gln Ala Thr Ile Ser Ser 
785                 790                 795                 800 


Lys Leu Gln Thr Cys Cys Asp Lys Pro Leu Leu Lys Lys Ala His Cys 
                805                 810                 815     


Leu Ser Glu Val Glu His Asp Thr Met Pro Ala Asp Leu Pro Ala Ile 
            820                 825                 830         


Ala Ala Asp Phe Val Glu Asp Gln Glu Val Cys Lys Asn Tyr Ala Glu 
        835                 840                 845             


Ala Lys Asp Val Phe Leu Gly Thr Phe Leu Tyr Glu Tyr Ser Arg Arg 
    850                 855                 860                 


His Pro Asp Tyr Ser Val Ser Leu Leu Leu Arg Leu Ala Lys Lys Tyr 
865                 870                 875                 880 


Glu Ala Thr Leu Glu Lys Cys Cys Ala Glu Ala Asn Pro Pro Ala Cys 
                885                 890                 895     


Tyr Gly Thr Val Leu Ala Glu Phe Gln Pro Leu Val Glu Glu Pro Lys 
            900                 905                 910         


Asn Leu Val Lys Thr Asn Cys Asp Leu Tyr Glu Lys Leu Gly Glu Tyr 
        915                 920                 925             


Gly Phe Gln Asn Ala Ile Leu Val Arg Tyr Thr Gln Lys Ala Pro Gln 
    930                 935                 940                 


Val Ser Thr Pro Thr Leu Val Glu Ala Ala Arg Asn Leu Gly Arg Val 
945                 950                 955                 960 


Gly Thr Lys Cys Cys Thr Leu Pro Glu Asp Gln Arg Leu Pro Cys Val 
                965                 970                 975     


Glu Asp Tyr Leu Ser Ala Ile Leu Asn Arg Val Cys Leu Leu His Glu 
            980                 985                 990         


Lys Thr Pro Val Ser Glu His Val  Thr Lys Cys Cys Ser  Gly Ser Leu 
        995                 1000                 1005             


Val Glu  Arg Arg Pro Cys Phe  Ser Ala Leu Thr Val  Asp Glu Thr 
    1010                 1015                 1020             


Tyr Val  Pro Lys Glu Phe Lys  Ala Glu Thr Phe Thr  Phe His Ser 
    1025                 1030                 1035             


Asp Ile  Cys Thr Leu Pro Glu  Lys Glu Lys Gln Ile  Lys Lys Gln 
    1040                 1045                 1050             


Thr Ala  Leu Ala Glu Leu Val  Lys His Lys Pro Lys  Ala Thr Ala 
    1055                 1060                 1065             


Glu Gln  Leu Lys Thr Val Met  Asp Asp Phe Ala Gln  Phe Leu Asp 
    1070                 1075                 1080             


Thr Cys  Cys Lys Ala Ala Asp  Lys Asp Thr Cys Phe  Ser Thr Glu 
    1085                 1090                 1095             


Gly Pro  Asn Leu Val Thr Arg  Cys Lys Asp Ala Leu  Ala Gly Gly 
    1100                 1105                 1110             


Gly Ser  Gly Gly Gly Ser Ser  Gln Tyr Tyr Asp Tyr  Asp Ile Pro 
    1115                 1120                 1125             


Leu Phe  Met Tyr Gly Gln Ile  Ser Pro Asn Cys Ala  Pro Glu Cys 
    1130                 1135                 1140             


Asn Cys  Pro His Ser Tyr Pro  Thr Ala Met Tyr Cys  Asp Asp Leu 
    1145                 1150                 1155             


Lys Leu  Lys Ser Val Pro Met  Val Pro Pro Gly Ile  Lys Tyr Leu 
    1160                 1165                 1170             


Tyr Leu  Arg Asn Asn Gln Ile  Asp His Ile Asp Glu  Lys Ala Phe 
    1175                 1180                 1185             


Glu Asn  Val Thr Asp Leu Gln  Trp Leu Ile Leu Asp  His Asn Leu 
    1190                 1195                 1200             


Leu Glu  Asn Ser Lys Ile Lys  Gly Lys Val Phe Ser  Lys Leu Lys 
    1205                 1210                 1215             


Gln Leu  Lys Lys Leu His Ile  Asn Tyr Asn Asn Leu  Thr Glu Ser 
    1220                 1225                 1230             


Val Gly  Pro Leu Pro Lys Ser  Leu Gln Asp Leu Gln  Leu Thr Asn 
    1235                 1240                 1245             


Asn Lys  Ile Ser Lys Leu Gly  Ser Phe Asp Gly Leu  Val Asn Leu 
    1250                 1255                 1260             


Thr Phe  Ile Tyr Leu Gln His  Asn Gln Leu Lys Glu  Asp Ala Val 
    1265                 1270                 1275             


Ser Ala  Ser Leu Lys Gly Leu  Lys Ser Leu Glu Tyr  Leu Asp Leu 
    1280                 1285                 1290             


Ser Phe  Asn Gln Met Ser Lys  Leu Pro Ala Gly Leu  Pro Thr Ser 
    1295                 1300                 1305             


Leu Leu  Thr Leu Tyr Leu Asp  Asn Asn Lys Ile Ser  Asn Ile Pro 
    1310                 1315                 1320             


Asp Glu  Tyr Phe Lys Arg Phe  Thr Gly Leu Gln Tyr  Leu Arg Leu 
    1325                 1330                 1335             


Ser His  Asn Glu Leu Ala Asp  Ser Gly Val Pro Gly  Asn Ser Phe 
    1340                 1345                 1350             


Asn Ile  Ser Ser Leu Leu Glu  Leu Asp Leu Ser Tyr  Asn Lys Leu 
    1355                 1360                 1365             


Lys Ser  Ile Pro Thr Val Asn  Glu Asn Leu Glu Asn  Tyr Tyr Leu 
    1370                 1375                 1380             


Glu Val  Asn Glu Leu Glu Lys  Phe Asp Val Lys Ser  Phe Cys Lys 
    1385                 1390                 1395             


Ile Leu  Gly Pro Leu Ser Tyr  Ser Lys Ile Lys His  Leu Arg Leu 
    1400                 1405                 1410             


Asp Gly  Asn Pro Leu Thr Gln  Ser Ser Leu Pro Pro  Asp Met Tyr 
    1415                 1420                 1425             


Glu Cys  Leu Arg Val Ala Asn  Glu Ile Thr Val Asn  Gly Gly Gly 
    1430                 1435                 1440             


Ser Gly  Gly Gly Ser Ala Pro  Thr Ser Ser Ser Thr  Ser Ser Ser 
    1445                 1450                 1455             


Thr Ala  Glu Ala Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    1460                 1465                 1470             


Gln His  Leu Glu Gln Leu Leu  Met Asp Leu Gln Glu  Leu Leu Ser 
    1475                 1480                 1485             


Arg Met  Glu Asn Tyr Arg Asn  Leu Lys Leu Pro Arg  Met Leu Thr 
    1490                 1495                 1500             


Phe Lys  Phe Tyr Leu Pro Lys  Gln Ala Thr Glu Leu  Lys Asp Leu 
    1505                 1510                 1515             


Gln Cys  Leu Glu Asp Glu Leu  Gly Pro Leu Arg His  Val Leu Asp 
    1520                 1525                 1530             


Leu Thr  Gln Ser Lys Ser Phe  Gln Leu Glu Asp Ala  Glu Asn Phe 
    1535                 1540                 1545             


Ile Ser  Asn Ile Arg Val Thr  Val Val Lys Leu Lys  Gly Ser Asp 
    1550                 1555                 1560             


Asn Thr  Phe Glu Cys Gln Phe  Asp Asp Glu Ser Ala  Thr Val Val 
    1565                 1570                 1575             


Asp Phe  Leu Arg Arg Trp Ile  Ala Phe Cys Gln Ser  Ile Ile Ser 
    1580                 1585                 1590             


Thr Ser  Pro Gln His His His  His His His His His  His His 
    1595                 1600                 1605         


<210> 26
<211> 1997
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Ser Gly Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Ser Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro 
                325                 330                 335     


Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp 
            340                 345                 350         


Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala 
        355                 360                 365             


Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu 
    370                 375                 380                 


Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala 
385                 390                 395                 400 


Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln 
                405                 410                 415     


Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp 
            420                 425                 430         


Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln 
        435                 440                 445             


Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala 
    450                 455                 460                 


Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg 
465                 470                 475                 480 


Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys 
                485                 490                 495     


Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn 
            500                 505                 510         


Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Ser Gly Gly Gly Ser Glu 
        515                 520                 525             


Ala His Lys Ser Glu Ile Ala His Arg Tyr Asn Asp Leu Gly Glu Gln 
    530                 535                 540                 


His Phe Lys Gly Leu Val Leu Ile Ala Phe Ser Gln Tyr Leu Gln Lys 
545                 550                 555                 560 


Cys Ser Tyr Asp Glu His Ala Lys Leu Val Gln Glu Val Thr Asp Phe 
                565                 570                 575     


Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Ala Asn Cys Asp Lys Ser 
            580                 585                 590         


Leu His Thr Leu Phe Gly Asp Lys Leu Cys Ala Ile Pro Asn Leu Arg 
        595                 600                 605             


Glu Asn Tyr Gly Glu Leu Ala Asp Cys Cys Thr Lys Gln Glu Pro Glu 
    610                 615                 620                 


Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Ser Leu Pro 
625                 630                 635                 640 


Pro Phe Glu Arg Pro Glu Ala Glu Ala Met Cys Thr Ser Phe Lys Glu 
                645                 650                 655     


Asn Pro Thr Thr Phe Met Gly His Tyr Leu His Glu Val Ala Arg Arg 
            660                 665                 670         


His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Tyr Tyr Ala Glu Gln Tyr 
        675                 680                 685             


Asn Glu Ile Leu Thr Gln Cys Cys Ala Glu Ala Asp Lys Glu Ser Cys 
    690                 695                 700                 


Leu Thr Pro Lys Leu Asp Gly Val Lys Glu Lys Ala Leu Val Ser Ser 
705                 710                 715                 720 


Val Arg Gln Arg Met Lys Cys Ser Ser Met Gln Lys Phe Gly Glu Arg 
                725                 730                 735     


Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Thr Phe Pro Asn 
            740                 745                 750         


Ala Asp Phe Ala Glu Ile Thr Lys Leu Ala Thr Asp Leu Thr Lys Val 
        755                 760                 765             


Asn Lys Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg 
    770                 775                 780                 


Ala Glu Leu Ala Lys Tyr Met Cys Glu Asn Gln Ala Thr Ile Ser Ser 
785                 790                 795                 800 


Lys Leu Gln Thr Cys Cys Asp Lys Pro Leu Leu Lys Lys Ala His Cys 
                805                 810                 815     


Leu Ser Glu Val Glu His Asp Thr Met Pro Ala Asp Leu Pro Ala Ile 
            820                 825                 830         


Ala Ala Asp Phe Val Glu Asp Gln Glu Val Cys Lys Asn Tyr Ala Glu 
        835                 840                 845             


Ala Lys Asp Val Phe Leu Gly Thr Phe Leu Tyr Glu Tyr Ser Arg Arg 
    850                 855                 860                 


His Pro Asp Tyr Ser Val Ser Leu Leu Leu Arg Leu Ala Lys Lys Tyr 
865                 870                 875                 880 


Glu Ala Thr Leu Glu Lys Cys Cys Ala Glu Ala Asn Pro Pro Ala Cys 
                885                 890                 895     


Tyr Gly Thr Val Leu Ala Glu Phe Gln Pro Leu Val Glu Glu Pro Lys 
            900                 905                 910         


Asn Leu Val Lys Thr Asn Cys Asp Leu Tyr Glu Lys Leu Gly Glu Tyr 
        915                 920                 925             


Gly Phe Gln Asn Ala Ile Leu Val Arg Tyr Thr Gln Lys Ala Pro Gln 
    930                 935                 940                 


Val Ser Thr Pro Thr Leu Val Glu Ala Ala Arg Asn Leu Gly Arg Val 
945                 950                 955                 960 


Gly Thr Lys Cys Cys Thr Leu Pro Glu Asp Gln Arg Leu Pro Cys Val 
                965                 970                 975     


Glu Asp Tyr Leu Ser Ala Ile Leu Asn Arg Val Cys Leu Leu His Glu 
            980                 985                 990         


Lys Thr Pro Val Ser Glu His Val  Thr Lys Cys Cys Ser  Gly Ser Leu 
        995                 1000                 1005             


Val Glu  Arg Arg Pro Cys Phe  Ser Ala Leu Thr Val  Asp Glu Thr 
    1010                 1015                 1020             


Tyr Val  Pro Lys Glu Phe Lys  Ala Glu Thr Phe Thr  Phe His Ser 
    1025                 1030                 1035             


Asp Ile  Cys Thr Leu Pro Glu  Lys Glu Lys Gln Ile  Lys Lys Gln 
    1040                 1045                 1050             


Thr Ala  Leu Ala Glu Leu Val  Lys His Lys Pro Lys  Ala Thr Ala 
    1055                 1060                 1065             


Glu Gln  Leu Lys Thr Val Met  Asp Asp Phe Ala Gln  Phe Leu Asp 
    1070                 1075                 1080             


Thr Cys  Cys Lys Ala Ala Asp  Lys Asp Thr Cys Phe  Ser Thr Glu 
    1085                 1090                 1095             


Gly Pro  Asn Leu Val Thr Arg  Cys Lys Asp Ala Leu  Ala Gly Gly 
    1100                 1105                 1110             


Gly Ser  Gly Gly Gly Ser Gln  Glu Gly Ser Leu Pro  Asp Ile Thr 
    1115                 1120                 1125             


Ile Phe  Pro Asn Ser Ser Leu  Met Ile Ser Gln Gly  Thr Phe Val 
    1130                 1135                 1140             


Thr Val  Val Cys Ser Tyr Ser  Asp Lys His Asp Leu  Tyr Asn Met 
    1145                 1150                 1155             


Val Arg  Leu Glu Lys Asp Gly  Ser Thr Phe Met Glu  Lys Ser Thr 
    1160                 1165                 1170             


Glu Pro  Tyr Lys Thr Glu Asp  Glu Phe Glu Ile Gly  Pro Val Asn 
    1175                 1180                 1185             


Glu Thr  Ile Thr Gly His Tyr  Ser Cys Ile Tyr Ser  Lys Gly Ile 
    1190                 1195                 1200             


Thr Trp  Ser Glu Arg Ser Lys  Thr Leu Glu Leu Lys  Val Ile Lys 
    1205                 1210                 1215             


Glu Asn  Val Ile Gln Thr Pro  Ala Pro Gly Pro Thr  Ser Asp Thr 
    1220                 1225                 1230             


Ser Trp  Leu Lys Thr Tyr Ser  Ile Tyr Gly Gly Gly  Ser Gly Gly 
    1235                 1240                 1245             


Gly Ser  Glu Ala His Lys Ser  Glu Ile Ala His Arg  Tyr Asn Asp 
    1250                 1255                 1260             


Leu Gly  Glu Gln His Phe Lys  Gly Leu Val Leu Ile  Ala Phe Ser 
    1265                 1270                 1275             


Gln Tyr  Leu Gln Lys Cys Ser  Tyr Asp Glu His Ala  Lys Leu Val 
    1280                 1285                 1290             


Gln Glu  Val Thr Asp Phe Ala  Lys Thr Cys Val Ala  Asp Glu Ser 
    1295                 1300                 1305             


Ala Ala  Asn Cys Asp Lys Ser  Leu His Thr Leu Phe  Gly Asp Lys 
    1310                 1315                 1320             


Leu Cys  Ala Ile Pro Asn Leu  Arg Glu Asn Tyr Gly  Glu Leu Ala 
    1325                 1330                 1335             


Asp Cys  Cys Thr Lys Gln Glu  Pro Glu Arg Asn Glu  Cys Phe Leu 
    1340                 1345                 1350             


Gln His  Lys Asp Asp Asn Pro  Ser Leu Pro Pro Phe  Glu Arg Pro 
    1355                 1360                 1365             


Glu Ala  Glu Ala Met Cys Thr  Ser Phe Lys Glu Asn  Pro Thr Thr 
    1370                 1375                 1380             


Phe Met  Gly His Tyr Leu His  Glu Val Ala Arg Arg  His Pro Tyr 
    1385                 1390                 1395             


Phe Tyr  Ala Pro Glu Leu Leu  Tyr Tyr Ala Glu Gln  Tyr Asn Glu 
    1400                 1405                 1410             


Ile Leu  Thr Gln Cys Cys Ala  Glu Ala Asp Lys Glu  Ser Cys Leu 
    1415                 1420                 1425             


Thr Pro  Lys Leu Asp Gly Val  Lys Glu Lys Ala Leu  Val Ser Ser 
    1430                 1435                 1440             


Val Arg  Gln Arg Met Lys Cys  Ser Ser Met Gln Lys  Phe Gly Glu 
    1445                 1450                 1455             


Arg Ala  Phe Lys Ala Trp Ala  Val Ala Arg Leu Ser  Gln Thr Phe 
    1460                 1465                 1470             


Pro Asn  Ala Asp Phe Ala Glu  Ile Thr Lys Leu Ala  Thr Asp Leu 
    1475                 1480                 1485             


Thr Lys  Val Asn Lys Glu Cys  Cys His Gly Asp Leu  Leu Glu Cys 
    1490                 1495                 1500             


Ala Asp  Asp Arg Ala Glu Leu  Ala Lys Tyr Met Cys  Glu Asn Gln 
    1505                 1510                 1515             


Ala Thr  Ile Ser Ser Lys Leu  Gln Thr Cys Cys Asp  Lys Pro Leu 
    1520                 1525                 1530             


Leu Lys  Lys Ala His Cys Leu  Ser Glu Val Glu His  Asp Thr Met 
    1535                 1540                 1545             


Pro Ala  Asp Leu Pro Ala Ile  Ala Ala Asp Phe Val  Glu Asp Gln 
    1550                 1555                 1560             


Glu Val  Cys Lys Asn Tyr Ala  Glu Ala Lys Asp Val  Phe Leu Gly 
    1565                 1570                 1575             


Thr Phe  Leu Tyr Glu Tyr Ser  Arg Arg His Pro Asp  Tyr Ser Val 
    1580                 1585                 1590             


Ser Leu  Leu Leu Arg Leu Ala  Lys Lys Tyr Glu Ala  Thr Leu Glu 
    1595                 1600                 1605             


Lys Cys  Cys Ala Glu Ala Asn  Pro Pro Ala Cys Tyr  Gly Thr Val 
    1610                 1615                 1620             


Leu Ala  Glu Phe Gln Pro Leu  Val Glu Glu Pro Lys  Asn Leu Val 
    1625                 1630                 1635             


Lys Thr  Asn Cys Asp Leu Tyr  Glu Lys Leu Gly Glu  Tyr Gly Phe 
    1640                 1645                 1650             


Gln Asn  Ala Ile Leu Val Arg  Tyr Thr Gln Lys Ala  Pro Gln Val 
    1655                 1660                 1665             


Ser Thr  Pro Thr Leu Val Glu  Ala Ala Arg Asn Leu  Gly Arg Val 
    1670                 1675                 1680             


Gly Thr  Lys Cys Cys Thr Leu  Pro Glu Asp Gln Arg  Leu Pro Cys 
    1685                 1690                 1695             


Val Glu  Asp Tyr Leu Ser Ala  Ile Leu Asn Arg Val  Cys Leu Leu 
    1700                 1705                 1710             


His Glu  Lys Thr Pro Val Ser  Glu His Val Thr Lys  Cys Cys Ser 
    1715                 1720                 1725             


Gly Ser  Leu Val Glu Arg Arg  Pro Cys Phe Ser Ala  Leu Thr Val 
    1730                 1735                 1740             


Asp Glu  Thr Tyr Val Pro Lys  Glu Phe Lys Ala Glu  Thr Phe Thr 
    1745                 1750                 1755             


Phe His  Ser Asp Ile Cys Thr  Leu Pro Glu Lys Glu  Lys Gln Ile 
    1760                 1765                 1770             


Lys Lys  Gln Thr Ala Leu Ala  Glu Leu Val Lys His  Lys Pro Lys 
    1775                 1780                 1785             


Ala Thr  Ala Glu Gln Leu Lys  Thr Val Met Asp Asp  Phe Ala Gln 
    1790                 1795                 1800             


Phe Leu  Asp Thr Cys Cys Lys  Ala Ala Asp Lys Asp  Thr Cys Phe 
    1805                 1810                 1815             


Ser Thr  Glu Gly Pro Asn Leu  Val Thr Arg Cys Lys  Asp Ala Leu 
    1820                 1825                 1830             


Ala Gly  Gly Gly Ser Ala Pro  Thr Ser Ser Ser Thr  Ser Ser Ser 
    1835                 1840                 1845             


Thr Ala  Glu Ala Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    1850                 1855                 1860             


Gln His  Leu Glu Gln Leu Leu  Met Asp Leu Gln Glu  Leu Leu Ser 
    1865                 1870                 1875             


Arg Met  Glu Asn Tyr Arg Asn  Leu Lys Leu Pro Arg  Met Leu Thr 
    1880                 1885                 1890             


Phe Lys  Phe Tyr Leu Pro Lys  Gln Ala Thr Glu Leu  Lys Asp Leu 
    1895                 1900                 1905             


Gln Cys  Leu Glu Asp Glu Leu  Gly Pro Leu Arg His  Val Leu Asp 
    1910                 1915                 1920             


Leu Thr  Gln Ser Lys Ser Phe  Gln Leu Glu Asp Ala  Glu Asn Phe 
    1925                 1930                 1935             


Ile Ser  Asn Ile Arg Val Thr  Val Val Lys Leu Lys  Gly Ser Asp 
    1940                 1945                 1950             


Asn Thr  Phe Glu Cys Gln Phe  Asp Asp Glu Ser Ala  Thr Val Val 
    1955                 1960                 1965             


Asp Phe  Leu Arg Arg Trp Ile  Ala Phe Cys Gln Ser  Ile Ile Ser 
    1970                 1975                 1980             


Thr Ser  Pro Gln His His His  His His His His His  His His 
    1985                 1990                 1995         


<210> 27
<211> 1407
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Ser Gly Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Ser Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro 
                325                 330                 335     


Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp 
            340                 345                 350         


Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala 
        355                 360                 365             


Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu 
    370                 375                 380                 


Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala 
385                 390                 395                 400 


Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln 
                405                 410                 415     


Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp 
            420                 425                 430         


Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln 
        435                 440                 445             


Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala 
    450                 455                 460                 


Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg 
465                 470                 475                 480 


Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys 
                485                 490                 495     


Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn 
            500                 505                 510         


Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly Gly Ser Gly Gly Gly 
        515                 520                 525             


Ser Gln Glu Gly Ser Leu Pro Asp Ile Thr Ile Phe Pro Asn Ser Ser 
    530                 535                 540                 


Leu Met Ile Ser Gln Gly Thr Phe Val Thr Val Val Cys Ser Tyr Ser 
545                 550                 555                 560 


Asp Lys His Asp Leu Tyr Asn Met Val Arg Leu Glu Lys Asp Gly Ser 
                565                 570                 575     


Thr Phe Met Glu Lys Ser Thr Glu Pro Tyr Lys Thr Glu Asp Glu Phe 
            580                 585                 590         


Glu Ile Gly Pro Val Asn Glu Thr Ile Thr Gly His Tyr Ser Cys Ile 
        595                 600                 605             


Tyr Ser Lys Gly Ile Thr Trp Ser Glu Arg Ser Lys Thr Leu Glu Leu 
    610                 615                 620                 


Lys Val Ile Lys Glu Asn Val Ile Gln Thr Pro Ala Pro Gly Pro Thr 
625                 630                 635                 640 


Ser Asp Thr Ser Trp Leu Lys Thr Tyr Ser Ile Tyr Gly Gly Gly Ser 
                645                 650                 655     


Gly Gly Gly Ser Glu Ala His Lys Ser Glu Ile Ala His Arg Tyr Asn 
            660                 665                 670         


Asp Leu Gly Glu Gln His Phe Lys Gly Leu Val Leu Ile Ala Phe Ser 
        675                 680                 685             


Gln Tyr Leu Gln Lys Cys Ser Tyr Asp Glu His Ala Lys Leu Val Gln 
    690                 695                 700                 


Glu Val Thr Asp Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Ala 
705                 710                 715                 720 


Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Ala 
                725                 730                 735     


Ile Pro Asn Leu Arg Glu Asn Tyr Gly Glu Leu Ala Asp Cys Cys Thr 
            740                 745                 750         


Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp 
        755                 760                 765             


Asn Pro Ser Leu Pro Pro Phe Glu Arg Pro Glu Ala Glu Ala Met Cys 
    770                 775                 780                 


Thr Ser Phe Lys Glu Asn Pro Thr Thr Phe Met Gly His Tyr Leu His 
785                 790                 795                 800 


Glu Val Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Tyr 
                805                 810                 815     


Tyr Ala Glu Gln Tyr Asn Glu Ile Leu Thr Gln Cys Cys Ala Glu Ala 
            820                 825                 830         


Asp Lys Glu Ser Cys Leu Thr Pro Lys Leu Asp Gly Val Lys Glu Lys 
        835                 840                 845             


Ala Leu Val Ser Ser Val Arg Gln Arg Met Lys Cys Ser Ser Met Gln 
    850                 855                 860                 


Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser 
865                 870                 875                 880 


Gln Thr Phe Pro Asn Ala Asp Phe Ala Glu Ile Thr Lys Leu Ala Thr 
                885                 890                 895     


Asp Leu Thr Lys Val Asn Lys Glu Cys Cys His Gly Asp Leu Leu Glu 
            900                 905                 910         


Cys Ala Asp Asp Arg Ala Glu Leu Ala Lys Tyr Met Cys Glu Asn Gln 
        915                 920                 925             


Ala Thr Ile Ser Ser Lys Leu Gln Thr Cys Cys Asp Lys Pro Leu Leu 
    930                 935                 940                 


Lys Lys Ala His Cys Leu Ser Glu Val Glu His Asp Thr Met Pro Ala 
945                 950                 955                 960 


Asp Leu Pro Ala Ile Ala Ala Asp Phe Val Glu Asp Gln Glu Val Cys 
                965                 970                 975     


Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Thr Phe Leu Tyr 
            980                 985                 990         


Glu Tyr Ser Arg Arg His Pro Asp  Tyr Ser Val Ser Leu  Leu Leu Arg 
        995                 1000                 1005             


Leu Ala  Lys Lys Tyr Glu Ala  Thr Leu Glu Lys Cys  Cys Ala Glu 
    1010                 1015                 1020             


Ala Asn  Pro Pro Ala Cys Tyr  Gly Thr Val Leu Ala  Glu Phe Gln 
    1025                 1030                 1035             


Pro Leu  Val Glu Glu Pro Lys  Asn Leu Val Lys Thr  Asn Cys Asp 
    1040                 1045                 1050             


Leu Tyr  Glu Lys Leu Gly Glu  Tyr Gly Phe Gln Asn  Ala Ile Leu 
    1055                 1060                 1065             


Val Arg  Tyr Thr Gln Lys Ala  Pro Gln Val Ser Thr  Pro Thr Leu 
    1070                 1075                 1080             


Val Glu  Ala Ala Arg Asn Leu  Gly Arg Val Gly Thr  Lys Cys Cys 
    1085                 1090                 1095             


Thr Leu  Pro Glu Asp Gln Arg  Leu Pro Cys Val Glu  Asp Tyr Leu 
    1100                 1105                 1110             


Ser Ala  Ile Leu Asn Arg Val  Cys Leu Leu His Glu  Lys Thr Pro 
    1115                 1120                 1125             


Val Ser  Glu His Val Thr Lys  Cys Cys Ser Gly Ser  Leu Val Glu 
    1130                 1135                 1140             


Arg Arg  Pro Cys Phe Ser Ala  Leu Thr Val Asp Glu  Thr Tyr Val 
    1145                 1150                 1155             


Pro Lys  Glu Phe Lys Ala Glu  Thr Phe Thr Phe His  Ser Asp Ile 
    1160                 1165                 1170             


Cys Thr  Leu Pro Glu Lys Glu  Lys Gln Ile Lys Lys  Gln Thr Ala 
    1175                 1180                 1185             


Leu Ala  Glu Leu Val Lys His  Lys Pro Lys Ala Thr  Ala Glu Gln 
    1190                 1195                 1200             


Leu Lys  Thr Val Met Asp Asp  Phe Ala Gln Phe Leu  Asp Thr Cys 
    1205                 1210                 1215             


Cys Lys  Ala Ala Asp Lys Asp  Thr Cys Phe Ser Thr  Glu Gly Pro 
    1220                 1225                 1230             


Asn Leu  Val Thr Arg Cys Lys  Asp Ala Leu Ala Gly  Gly Gly Ser 
    1235                 1240                 1245             


Ala Pro  Thr Ser Ser Ser Thr  Ser Ser Ser Thr Ala  Glu Ala Gln 
    1250                 1255                 1260             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln His  Leu Glu Gln 
    1265                 1270                 1275             


Leu Leu  Met Asp Leu Gln Glu  Leu Leu Ser Arg Met  Glu Asn Tyr 
    1280                 1285                 1290             


Arg Asn  Leu Lys Leu Pro Arg  Met Leu Thr Phe Lys  Phe Tyr Leu 
    1295                 1300                 1305             


Pro Lys  Gln Ala Thr Glu Leu  Lys Asp Leu Gln Cys  Leu Glu Asp 
    1310                 1315                 1320             


Glu Leu  Gly Pro Leu Arg His  Val Leu Asp Leu Thr  Gln Ser Lys 
    1325                 1330                 1335             


Ser Phe  Gln Leu Glu Asp Ala  Glu Asn Phe Ile Ser  Asn Ile Arg 
    1340                 1345                 1350             


Val Thr  Val Val Lys Leu Lys  Gly Ser Asp Asn Thr  Phe Glu Cys 
    1355                 1360                 1365             


Gln Phe  Asp Asp Glu Ser Ala  Thr Val Val Asp Phe  Leu Arg Arg 
    1370                 1375                 1380             


Trp Ile  Ala Phe Cys Gln Ser  Ile Ile Ser Thr Ser  Pro Gln His 
    1385                 1390                 1395             


His His  His His His His His  His His 
    1400                 1405         


<210> 28
<211> 1409
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 28
Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Ser Gly Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Ser Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro 
                325                 330                 335     


Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp 
            340                 345                 350         


Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala 
        355                 360                 365             


Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu 
    370                 375                 380                 


Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala 
385                 390                 395                 400 


Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln 
                405                 410                 415     


Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp 
            420                 425                 430         


Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln 
        435                 440                 445             


Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala 
    450                 455                 460                 


Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg 
465                 470                 475                 480 


Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys 
                485                 490                 495     


Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn 
            500                 505                 510         


Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Ser Gly Gly Gly Ser Glu 
        515                 520                 525             


Ala His Lys Ser Glu Ile Ala His Arg Tyr Asn Asp Leu Gly Glu Gln 
    530                 535                 540                 


His Phe Lys Gly Leu Val Leu Ile Ala Phe Ser Gln Tyr Leu Gln Lys 
545                 550                 555                 560 


Cys Ser Tyr Asp Glu His Ala Lys Leu Val Gln Glu Val Thr Asp Phe 
                565                 570                 575     


Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Ala Asn Cys Asp Lys Ser 
            580                 585                 590         


Leu His Thr Leu Phe Gly Asp Lys Leu Cys Ala Ile Pro Asn Leu Arg 
        595                 600                 605             


Glu Asn Tyr Gly Glu Leu Ala Asp Cys Cys Thr Lys Gln Glu Pro Glu 
    610                 615                 620                 


Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Ser Leu Pro 
625                 630                 635                 640 


Pro Phe Glu Arg Pro Glu Ala Glu Ala Met Cys Thr Ser Phe Lys Glu 
                645                 650                 655     


Asn Pro Thr Thr Phe Met Gly His Tyr Leu His Glu Val Ala Arg Arg 
            660                 665                 670         


His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Tyr Tyr Ala Glu Gln Tyr 
        675                 680                 685             


Asn Glu Ile Leu Thr Gln Cys Cys Ala Glu Ala Asp Lys Glu Ser Cys 
    690                 695                 700                 


Leu Thr Pro Lys Leu Asp Gly Val Lys Glu Lys Ala Leu Val Ser Ser 
705                 710                 715                 720 


Val Arg Gln Arg Met Lys Cys Ser Ser Met Gln Lys Phe Gly Glu Arg 
                725                 730                 735     


Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Thr Phe Pro Asn 
            740                 745                 750         


Ala Asp Phe Ala Glu Ile Thr Lys Leu Ala Thr Asp Leu Thr Lys Val 
        755                 760                 765             


Asn Lys Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg 
    770                 775                 780                 


Ala Glu Leu Ala Lys Tyr Met Cys Glu Asn Gln Ala Thr Ile Ser Ser 
785                 790                 795                 800 


Lys Leu Gln Thr Cys Cys Asp Lys Pro Leu Leu Lys Lys Ala His Cys 
                805                 810                 815     


Leu Ser Glu Val Glu His Asp Thr Met Pro Ala Asp Leu Pro Ala Ile 
            820                 825                 830         


Ala Ala Asp Phe Val Glu Asp Gln Glu Val Cys Lys Asn Tyr Ala Glu 
        835                 840                 845             


Ala Lys Asp Val Phe Leu Gly Thr Phe Leu Tyr Glu Tyr Ser Arg Arg 
    850                 855                 860                 


His Pro Asp Tyr Ser Val Ser Leu Leu Leu Arg Leu Ala Lys Lys Tyr 
865                 870                 875                 880 


Glu Ala Thr Leu Glu Lys Cys Cys Ala Glu Ala Asn Pro Pro Ala Cys 
                885                 890                 895     


Tyr Gly Thr Val Leu Ala Glu Phe Gln Pro Leu Val Glu Glu Pro Lys 
            900                 905                 910         


Asn Leu Val Lys Thr Asn Cys Asp Leu Tyr Glu Lys Leu Gly Glu Tyr 
        915                 920                 925             


Gly Phe Gln Asn Ala Ile Leu Val Arg Tyr Thr Gln Lys Ala Pro Gln 
    930                 935                 940                 


Val Ser Thr Pro Thr Leu Val Glu Ala Ala Arg Asn Leu Gly Arg Val 
945                 950                 955                 960 


Gly Thr Lys Cys Cys Thr Leu Pro Glu Asp Gln Arg Leu Pro Cys Val 
                965                 970                 975     


Glu Asp Tyr Leu Ser Ala Ile Leu Asn Arg Val Cys Leu Leu His Glu 
            980                 985                 990         


Lys Thr Pro Val Ser Glu His Val  Thr Lys Cys Cys Ser  Gly Ser Leu 
        995                 1000                 1005             


Val Glu  Arg Arg Pro Cys Phe  Ser Ala Leu Thr Val  Asp Glu Thr 
    1010                 1015                 1020             


Tyr Val  Pro Lys Glu Phe Lys  Ala Glu Thr Phe Thr  Phe His Ser 
    1025                 1030                 1035             


Asp Ile  Cys Thr Leu Pro Glu  Lys Glu Lys Gln Ile  Lys Lys Gln 
    1040                 1045                 1050             


Thr Ala  Leu Ala Glu Leu Val  Lys His Lys Pro Lys  Ala Thr Ala 
    1055                 1060                 1065             


Glu Gln  Leu Lys Thr Val Met  Asp Asp Phe Ala Gln  Phe Leu Asp 
    1070                 1075                 1080             


Thr Cys  Cys Lys Ala Ala Asp  Lys Asp Thr Cys Phe  Ser Thr Glu 
    1085                 1090                 1095             


Gly Pro  Asn Leu Val Thr Arg  Cys Lys Asp Ala Leu  Ala Gly Gly 
    1100                 1105                 1110             


Gly Ser  Gly Gly Gly Ser Gln  Glu Gly Ser Leu Pro  Asp Ile Thr 
    1115                 1120                 1125             


Ile Phe  Pro Asn Ser Ser Leu  Met Ile Ser Gln Gly  Thr Phe Val 
    1130                 1135                 1140             


Thr Val  Val Cys Ser Tyr Ser  Asp Lys His Asp Leu  Tyr Asn Met 
    1145                 1150                 1155             


Val Arg  Leu Glu Lys Asp Gly  Ser Thr Phe Met Glu  Lys Ser Thr 
    1160                 1165                 1170             


Glu Pro  Tyr Lys Thr Glu Asp  Glu Phe Glu Ile Gly  Pro Val Asn 
    1175                 1180                 1185             


Glu Thr  Ile Thr Gly His Tyr  Ser Cys Ile Tyr Ser  Lys Gly Ile 
    1190                 1195                 1200             


Thr Trp  Ser Glu Arg Ser Lys  Thr Leu Glu Leu Lys  Val Ile Lys 
    1205                 1210                 1215             


Glu Asn  Val Ile Gln Thr Pro  Ala Pro Gly Pro Thr  Ser Asp Thr 
    1220                 1225                 1230             


Ser Trp  Leu Lys Thr Tyr Ser  Ile Tyr Gly Gly Gly  Ser Gly Gly 
    1235                 1240                 1245             


Gly Ser  Ala Pro Thr Ser Ser  Ser Thr Ser Ser Ser  Thr Ala Glu 
    1250                 1255                 1260             


Ala Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Gln His Leu 
    1265                 1270                 1275             


Glu Gln  Leu Leu Met Asp Leu  Gln Glu Leu Leu Ser  Arg Met Glu 
    1280                 1285                 1290             


Asn Tyr  Arg Asn Leu Lys Leu  Pro Arg Met Leu Thr  Phe Lys Phe 
    1295                 1300                 1305             


Tyr Leu  Pro Lys Gln Ala Thr  Glu Leu Lys Asp Leu  Gln Cys Leu 
    1310                 1315                 1320             


Glu Asp  Glu Leu Gly Pro Leu  Arg His Val Leu Asp  Leu Thr Gln 
    1325                 1330                 1335             


Ser Lys  Ser Phe Gln Leu Glu  Asp Ala Glu Asn Phe  Ile Ser Asn 
    1340                 1345                 1350             


Ile Arg  Val Thr Val Val Lys  Leu Lys Gly Ser Asp  Asn Thr Phe 
    1355                 1360                 1365             


Glu Cys  Gln Phe Asp Asp Glu  Ser Ala Thr Val Val  Asp Phe Leu 
    1370                 1375                 1380             


Arg Arg  Trp Ile Ala Phe Cys  Gln Ser Ile Ile Ser  Thr Ser Pro 
    1385                 1390                 1395             


Gln His  His His His His His  His His His His 
    1400                 1405                 


<210> 29
<211> 1157
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 29
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val 
            20                  25                  30          


Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr 
        35                  40                  45              


Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg 
    50                  55                  60                  


His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu 
65                  70                  75                  80  


Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu 
                85                  90                  95      


Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser 
            100                 105                 110         


Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu 
        115                 120                 125             


Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg 
    130                 135                 140                 


Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp 
145                 150                 155                 160 


Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val 
                165                 170                 175     


Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu 
            180                 185                 190         


Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala 
        195                 200                 205             


Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe 
    210                 215                 220                 


Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met 
225                 230                 235                 240 


Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp 
                245                 250                 255     


Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg 
            260                 265                 270         


Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn 
        275                 280                 285             


Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys 
    290                 295                 300                 


Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser 
305                 310                 315                 320 


Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly 
                325                 330                 335     


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Val Ile 
            340                 345                 350         


Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu 
        355                 360                 365             


Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys Leu Lys His 
    370                 375                 380                 


Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp 
385                 390                 395                 400 


Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn 
                405                 410                 415     


Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser 
            420                 425                 430         


Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly 
        435                 440                 445             


Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile 
    450                 455                 460                 


Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile Leu Asp Lys 
465                 470                 475                 480 


Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn 
                485                 490                 495     


Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr 
            500                 505                 510         


Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg 
        515                 520                 525             


Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly 
    530                 535                 540                 


Gly Ser Gly Gly Gly Ser Ser Gln Tyr Tyr Asp Tyr Asp Ile Pro Leu 
545                 550                 555                 560 


Phe Met Tyr Gly Gln Ile Ser Pro Asn Cys Ala Pro Glu Cys Asn Cys 
                565                 570                 575     


Pro His Ser Tyr Pro Thr Ala Met Tyr Cys Asp Asp Leu Lys Leu Lys 
            580                 585                 590         


Ser Val Pro Met Val Pro Pro Gly Ile Lys Tyr Leu Tyr Leu Arg Asn 
        595                 600                 605             


Asn Gln Ile Asp His Ile Asp Glu Lys Ala Phe Glu Asn Val Thr Asp 
    610                 615                 620                 


Leu Gln Trp Leu Ile Leu Asp His Asn Leu Leu Glu Asn Ser Lys Ile 
625                 630                 635                 640 


Lys Gly Lys Val Phe Ser Lys Leu Lys Gln Leu Lys Lys Leu His Ile 
                645                 650                 655     


Asn Tyr Asn Asn Leu Thr Glu Ser Val Gly Pro Leu Pro Lys Ser Leu 
            660                 665                 670         


Gln Asp Leu Gln Leu Thr Asn Asn Lys Ile Ser Lys Leu Gly Ser Phe 
        675                 680                 685             


Asp Gly Leu Val Asn Leu Thr Phe Ile Tyr Leu Gln His Asn Gln Leu 
    690                 695                 700                 


Lys Glu Asp Ala Val Ser Ala Ser Leu Lys Gly Leu Lys Ser Leu Glu 
705                 710                 715                 720 


Tyr Leu Asp Leu Ser Phe Asn Gln Met Ser Lys Leu Pro Ala Gly Leu 
                725                 730                 735     


Pro Thr Ser Leu Leu Thr Leu Tyr Leu Asp Asn Asn Lys Ile Ser Asn 
            740                 745                 750         


Ile Pro Asp Glu Tyr Phe Lys Arg Phe Thr Gly Leu Gln Tyr Leu Arg 
        755                 760                 765             


Leu Ser His Asn Glu Leu Ala Asp Ser Gly Val Pro Gly Asn Ser Phe 
    770                 775                 780                 


Asn Ile Ser Ser Leu Leu Glu Leu Asp Leu Ser Tyr Asn Lys Leu Lys 
785                 790                 795                 800 


Ser Ile Pro Thr Val Asn Glu Asn Leu Glu Asn Tyr Tyr Leu Glu Val 
                805                 810                 815     


Asn Glu Leu Glu Lys Phe Asp Val Lys Ser Phe Cys Lys Ile Leu Gly 
            820                 825                 830         


Pro Leu Ser Tyr Ser Lys Ile Lys His Leu Arg Leu Asp Gly Asn Pro 
        835                 840                 845             


Leu Thr Gln Ser Ser Leu Pro Pro Asp Met Tyr Glu Cys Leu Arg Val 
    850                 855                 860                 


Ala Asn Glu Ile Thr Val Asn Gly Gly Gly Ser Gly Gly Gly Ser Lys 
865                 870                 875                 880 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                885                 890                 895     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
            900                 905                 910         


Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
        915                 920                 925             


Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Arg 
    930                 935                 940                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
945                 950                 955                 960 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                965                 970                 975     


Ile Gly Gly Ser Leu Ser Pro Ser Ser Gln Gly Thr Leu Val Thr Val 
            980                 985                 990         


Ser Ser Gly Gly Gly Ser Ala Pro  Thr Ser Ser Ser Thr  Ser Ser Ser 
        995                 1000                 1005             


Thr Ala  Glu Ala Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    1010                 1015                 1020             


Gln His  Leu Glu Gln Leu Leu  Met Asp Leu Gln Glu  Leu Leu Ser 
    1025                 1030                 1035             


Arg Met  Glu Asn Tyr Arg Asn  Leu Lys Leu Pro Arg  Met Leu Thr 
    1040                 1045                 1050             


Phe Lys  Phe Tyr Leu Pro Lys  Gln Ala Thr Glu Leu  Lys Asp Leu 
    1055                 1060                 1065             


Gln Cys  Leu Glu Asp Glu Leu  Gly Pro Leu Arg His  Val Leu Asp 
    1070                 1075                 1080             


Leu Thr  Gln Ser Lys Ser Phe  Gln Leu Glu Asp Ala  Glu Asn Phe 
    1085                 1090                 1095             


Ile Ser  Asn Ile Arg Val Thr  Val Val Lys Leu Lys  Gly Ser Asp 
    1100                 1105                 1110             


Asn Thr  Phe Glu Cys Gln Phe  Asp Asp Glu Ser Ala  Thr Val Val 
    1115                 1120                 1125             


Asp Phe  Leu Arg Arg Trp Ile  Ala Phe Cys Gln Ser  Ile Ile Ser 
    1130                 1135                 1140             


Thr Ser  Pro Gln His His His  His His His His His  His His 
    1145                 1150                 1155         


<210> 30
<211> 959
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val 
            20                  25                  30          


Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr 
        35                  40                  45              


Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg 
    50                  55                  60                  


His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu 
65                  70                  75                  80  


Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu 
                85                  90                  95      


Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser 
            100                 105                 110         


Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu 
        115                 120                 125             


Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg 
    130                 135                 140                 


Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp 
145                 150                 155                 160 


Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val 
                165                 170                 175     


Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu 
            180                 185                 190         


Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala 
        195                 200                 205             


Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe 
    210                 215                 220                 


Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met 
225                 230                 235                 240 


Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp 
                245                 250                 255     


Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg 
            260                 265                 270         


Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn 
        275                 280                 285             


Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys 
    290                 295                 300                 


Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser 
305                 310                 315                 320 


Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly 
                325                 330                 335     


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Val Ile 
            340                 345                 350         


Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu 
        355                 360                 365             


Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys Leu Lys His 
    370                 375                 380                 


Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp 
385                 390                 395                 400 


Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn 
                405                 410                 415     


Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser 
            420                 425                 430         


Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly 
        435                 440                 445             


Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile 
    450                 455                 460                 


Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile Leu Asp Lys 
465                 470                 475                 480 


Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn 
                485                 490                 495     


Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr 
            500                 505                 510         


Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg 
        515                 520                 525             


Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly 
    530                 535                 540                 


Gly Ser Gly Gly Gly Ser Gln Glu Gly Ser Leu Pro Asp Ile Thr Ile 
545                 550                 555                 560 


Phe Pro Asn Ser Ser Leu Met Ile Ser Gln Gly Thr Phe Val Thr Val 
                565                 570                 575     


Val Cys Ser Tyr Ser Asp Lys His Asp Leu Tyr Asn Met Val Arg Leu 
            580                 585                 590         


Glu Lys Asp Gly Ser Thr Phe Met Glu Lys Ser Thr Glu Pro Tyr Lys 
        595                 600                 605             


Thr Glu Asp Glu Phe Glu Ile Gly Pro Val Asn Glu Thr Ile Thr Gly 
    610                 615                 620                 


His Tyr Ser Cys Ile Tyr Ser Lys Gly Ile Thr Trp Ser Glu Arg Ser 
625                 630                 635                 640 


Lys Thr Leu Glu Leu Lys Val Ile Lys Glu Asn Val Ile Gln Thr Pro 
                645                 650                 655     


Ala Pro Gly Pro Thr Ser Asp Thr Ser Trp Leu Lys Thr Tyr Ser Ile 
            660                 665                 670         


Tyr Gly Gly Gly Ser Gly Gly Gly Ser Lys Val Gln Leu Val Glu Ser 
        675                 680                 685             


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
    690                 695                 700                 


Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Thr Trp Val Arg Gln 
705                 710                 715                 720 


Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly 
                725                 730                 735     


Ser Asp Thr Leu Tyr Ala Asp Ser Val Arg Gly Arg Phe Thr Ile Ser 
            740                 745                 750         


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
        755                 760                 765             


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser 
    770                 775                 780                 


Pro Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser 
785                 790                 795                 800 


Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala Glu Ala Gln Gln 
                805                 810                 815     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu Glu Gln Leu Leu 
            820                 825                 830         


Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn Tyr Arg Asn Leu 
        835                 840                 845             


Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu Pro Lys Gln Ala 
    850                 855                 860                 


Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu Leu Gly Pro Leu 
865                 870                 875                 880 


Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe Gln Leu Glu Asp 
                885                 890                 895     


Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val Val Lys Leu Lys 
            900                 905                 910         


Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp Glu Ser Ala Thr 
        915                 920                 925             


Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys Gln Ser Ile Ile 
    930                 935                 940                 


Ser Thr Ser Pro Gln His His His His His His His His His His 
945                 950                 955                 


<210> 31
<211> 1626
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 31
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val 
            20                  25                  30          


Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr 
        35                  40                  45              


Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg 
    50                  55                  60                  


His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu 
65                  70                  75                  80  


Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu 
                85                  90                  95      


Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser 
            100                 105                 110         


Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu 
        115                 120                 125             


Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg 
    130                 135                 140                 


Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp 
145                 150                 155                 160 


Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val 
                165                 170                 175     


Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu 
            180                 185                 190         


Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala 
        195                 200                 205             


Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe 
    210                 215                 220                 


Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met 
225                 230                 235                 240 


Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp 
                245                 250                 255     


Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg 
            260                 265                 270         


Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn 
        275                 280                 285             


Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys 
    290                 295                 300                 


Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser 
305                 310                 315                 320 


Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly 
                325                 330                 335     


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Val Ile 
            340                 345                 350         


Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu 
        355                 360                 365             


Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys Leu Lys His 
    370                 375                 380                 


Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp 
385                 390                 395                 400 


Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn 
                405                 410                 415     


Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser 
            420                 425                 430         


Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly 
        435                 440                 445             


Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile 
    450                 455                 460                 


Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile Leu Asp Lys 
465                 470                 475                 480 


Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn 
                485                 490                 495     


Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr 
            500                 505                 510         


Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg 
        515                 520                 525             


Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly 
    530                 535                 540                 


Gly Ser Gly Gly Gly Ser Ser Gln Tyr Tyr Asp Tyr Asp Ile Pro Leu 
545                 550                 555                 560 


Phe Met Tyr Gly Gln Ile Ser Pro Asn Cys Ala Pro Glu Cys Asn Cys 
                565                 570                 575     


Pro His Ser Tyr Pro Thr Ala Met Tyr Cys Asp Asp Leu Lys Leu Lys 
            580                 585                 590         


Ser Val Pro Met Val Pro Pro Gly Ile Lys Tyr Leu Tyr Leu Arg Asn 
        595                 600                 605             


Asn Gln Ile Asp His Ile Asp Glu Lys Ala Phe Glu Asn Val Thr Asp 
    610                 615                 620                 


Leu Gln Trp Leu Ile Leu Asp His Asn Leu Leu Glu Asn Ser Lys Ile 
625                 630                 635                 640 


Lys Gly Lys Val Phe Ser Lys Leu Lys Gln Leu Lys Lys Leu His Ile 
                645                 650                 655     


Asn Tyr Asn Asn Leu Thr Glu Ser Val Gly Pro Leu Pro Lys Ser Leu 
            660                 665                 670         


Gln Asp Leu Gln Leu Thr Asn Asn Lys Ile Ser Lys Leu Gly Ser Phe 
        675                 680                 685             


Asp Gly Leu Val Asn Leu Thr Phe Ile Tyr Leu Gln His Asn Gln Leu 
    690                 695                 700                 


Lys Glu Asp Ala Val Ser Ala Ser Leu Lys Gly Leu Lys Ser Leu Glu 
705                 710                 715                 720 


Tyr Leu Asp Leu Ser Phe Asn Gln Met Ser Lys Leu Pro Ala Gly Leu 
                725                 730                 735     


Pro Thr Ser Leu Leu Thr Leu Tyr Leu Asp Asn Asn Lys Ile Ser Asn 
            740                 745                 750         


Ile Pro Asp Glu Tyr Phe Lys Arg Phe Thr Gly Leu Gln Tyr Leu Arg 
        755                 760                 765             


Leu Ser His Asn Glu Leu Ala Asp Ser Gly Val Pro Gly Asn Ser Phe 
    770                 775                 780                 


Asn Ile Ser Ser Leu Leu Glu Leu Asp Leu Ser Tyr Asn Lys Leu Lys 
785                 790                 795                 800 


Ser Ile Pro Thr Val Asn Glu Asn Leu Glu Asn Tyr Tyr Leu Glu Val 
                805                 810                 815     


Asn Glu Leu Glu Lys Phe Asp Val Lys Ser Phe Cys Lys Ile Leu Gly 
            820                 825                 830         


Pro Leu Ser Tyr Ser Lys Ile Lys His Leu Arg Leu Asp Gly Asn Pro 
        835                 840                 845             


Leu Thr Gln Ser Ser Leu Pro Pro Asp Met Tyr Glu Cys Leu Arg Val 
    850                 855                 860                 


Ala Asn Glu Ile Thr Val Asn Gly Gly Gly Ser Gly Gly Gly Ser Glu 
865                 870                 875                 880 


Ala His Lys Ser Glu Ile Ala His Arg Tyr Asn Asp Leu Gly Glu Gln 
                885                 890                 895     


His Phe Lys Gly Leu Val Leu Ile Ala Phe Ser Gln Tyr Leu Gln Lys 
            900                 905                 910         


Cys Ser Tyr Asp Glu His Ala Lys Leu Val Gln Glu Val Thr Asp Phe 
        915                 920                 925             


Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Ala Asn Cys Asp Lys Ser 
    930                 935                 940                 


Leu His Thr Leu Phe Gly Asp Lys Leu Cys Ala Ile Pro Asn Leu Arg 
945                 950                 955                 960 


Glu Asn Tyr Gly Glu Leu Ala Asp Cys Cys Thr Lys Gln Glu Pro Glu 
                965                 970                 975     


Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Ser Leu Pro 
            980                 985                 990         


Pro Phe Glu Arg Pro Glu Ala Glu  Ala Met Cys Thr Ser  Phe Lys Glu 
        995                 1000                 1005             


Asn Pro  Thr Thr Phe Met Gly  His Tyr Leu His Glu  Val Ala Arg 
    1010                 1015                 1020             


Arg His  Pro Tyr Phe Tyr Ala  Pro Glu Leu Leu Tyr  Tyr Ala Glu 
    1025                 1030                 1035             


Gln Tyr  Asn Glu Ile Leu Thr  Gln Cys Cys Ala Glu  Ala Asp Lys 
    1040                 1045                 1050             


Glu Ser  Cys Leu Thr Pro Lys  Leu Asp Gly Val Lys  Glu Lys Ala 
    1055                 1060                 1065             


Leu Val  Ser Ser Val Arg Gln  Arg Met Lys Cys Ser  Ser Met Gln 
    1070                 1075                 1080             


Lys Phe  Gly Glu Arg Ala Phe  Lys Ala Trp Ala Val  Ala Arg Leu 
    1085                 1090                 1095             


Ser Gln  Thr Phe Pro Asn Ala  Asp Phe Ala Glu Ile  Thr Lys Leu 
    1100                 1105                 1110             


Ala Thr  Asp Leu Thr Lys Val  Asn Lys Glu Cys Cys  His Gly Asp 
    1115                 1120                 1125             


Leu Leu  Glu Cys Ala Asp Asp  Arg Ala Glu Leu Ala  Lys Tyr Met 
    1130                 1135                 1140             


Cys Glu  Asn Gln Ala Thr Ile  Ser Ser Lys Leu Gln  Thr Cys Cys 
    1145                 1150                 1155             


Asp Lys  Pro Leu Leu Lys Lys  Ala His Cys Leu Ser  Glu Val Glu 
    1160                 1165                 1170             


His Asp  Thr Met Pro Ala Asp  Leu Pro Ala Ile Ala  Ala Asp Phe 
    1175                 1180                 1185             


Val Glu  Asp Gln Glu Val Cys  Lys Asn Tyr Ala Glu  Ala Lys Asp 
    1190                 1195                 1200             


Val Phe  Leu Gly Thr Phe Leu  Tyr Glu Tyr Ser Arg  Arg His Pro 
    1205                 1210                 1215             


Asp Tyr  Ser Val Ser Leu Leu  Leu Arg Leu Ala Lys  Lys Tyr Glu 
    1220                 1225                 1230             


Ala Thr  Leu Glu Lys Cys Cys  Ala Glu Ala Asn Pro  Pro Ala Cys 
    1235                 1240                 1245             


Tyr Gly  Thr Val Leu Ala Glu  Phe Gln Pro Leu Val  Glu Glu Pro 
    1250                 1255                 1260             


Lys Asn  Leu Val Lys Thr Asn  Cys Asp Leu Tyr Glu  Lys Leu Gly 
    1265                 1270                 1275             


Glu Tyr  Gly Phe Gln Asn Ala  Ile Leu Val Arg Tyr  Thr Gln Lys 
    1280                 1285                 1290             


Ala Pro  Gln Val Ser Thr Pro  Thr Leu Val Glu Ala  Ala Arg Asn 
    1295                 1300                 1305             


Leu Gly  Arg Val Gly Thr Lys  Cys Cys Thr Leu Pro  Glu Asp Gln 
    1310                 1315                 1320             


Arg Leu  Pro Cys Val Glu Asp  Tyr Leu Ser Ala Ile  Leu Asn Arg 
    1325                 1330                 1335             


Val Cys  Leu Leu Gln Glu Lys  Thr Pro Val Ser Glu  His Val Thr 
    1340                 1345                 1350             


Lys Cys  Cys Ser Gly Ser Leu  Val Glu Arg Arg Pro  Cys Phe Ser 
    1355                 1360                 1365             


Ala Leu  Thr Val Asp Glu Thr  Tyr Val Pro Lys Glu  Phe Lys Ala 
    1370                 1375                 1380             


Glu Thr  Phe Thr Phe His Ser  Asp Ile Cys Thr Leu  Pro Glu Lys 
    1385                 1390                 1395             


Glu Lys  Gln Ile Lys Lys Gln  Thr Ala Leu Ala Glu  Leu Val Lys 
    1400                 1405                 1410             


His Lys  Pro Lys Ala Thr Ala  Glu Gln Leu Lys Thr  Val Met Asp 
    1415                 1420                 1425             


Asp Phe  Ala Gln Phe Leu Asp  Thr Cys Cys Lys Ala  Ala Asp Lys 
    1430                 1435                 1440             


Asp Thr  Cys Phe Ser Thr Glu  Gly Pro Asn Leu Val  Thr Arg Cys 
    1445                 1450                 1455             


Lys Asp  Ala Leu Ala Gly Gly  Gly Ser Ala Pro Thr  Ser Ser Ser 
    1460                 1465                 1470             


Thr Ser  Ser Ser Thr Ala Glu  Ala Gln Gln Gln Gln  Gln Gln Gln 
    1475                 1480                 1485             


Gln Gln  Gln Gln Gln His Leu  Glu Gln Leu Leu Met  Asp Leu Gln 
    1490                 1495                 1500             


Glu Leu  Leu Ser Arg Met Glu  Asn Tyr Arg Asn Leu  Lys Leu Pro 
    1505                 1510                 1515             


Arg Met  Leu Thr Phe Lys Phe  Tyr Leu Pro Lys Gln  Ala Thr Glu 
    1520                 1525                 1530             


Leu Lys  Asp Leu Gln Cys Leu  Glu Asp Glu Leu Gly  Pro Leu Arg 
    1535                 1540                 1545             


His Val  Leu Asp Leu Thr Gln  Ser Lys Ser Phe Gln  Leu Glu Asp 
    1550                 1555                 1560             


Ala Glu  Asn Phe Ile Ser Asn  Ile Arg Val Thr Val  Val Lys Leu 
    1565                 1570                 1575             


Lys Gly  Ser Asp Asn Thr Phe  Glu Cys Gln Phe Asp  Asp Glu Ser 
    1580                 1585                 1590             


Ala Thr  Val Val Asp Phe Leu  Arg Arg Trp Ile Ala  Phe Cys Gln 
    1595                 1600                 1605             


Ser Ile  Ile Ser Thr Ser Pro  Gln His His His His  His His His 
    1610                 1615                 1620             


His His  His 
    1625     


<210> 32
<211> 1428
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 32
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val 
            20                  25                  30          


Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr 
        35                  40                  45              


Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg 
    50                  55                  60                  


His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu 
65                  70                  75                  80  


Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu 
                85                  90                  95      


Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser 
            100                 105                 110         


Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu 
        115                 120                 125             


Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg 
    130                 135                 140                 


Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp 
145                 150                 155                 160 


Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val 
                165                 170                 175     


Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu 
            180                 185                 190         


Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala 
        195                 200                 205             


Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe 
    210                 215                 220                 


Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met 
225                 230                 235                 240 


Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp 
                245                 250                 255     


Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg 
            260                 265                 270         


Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn 
        275                 280                 285             


Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys 
    290                 295                 300                 


Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser 
305                 310                 315                 320 


Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly 
                325                 330                 335     


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Val Ile 
            340                 345                 350         


Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu 
        355                 360                 365             


Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys Leu Lys His 
    370                 375                 380                 


Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp 
385                 390                 395                 400 


Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn 
                405                 410                 415     


Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser 
            420                 425                 430         


Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly 
        435                 440                 445             


Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile 
    450                 455                 460                 


Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile Leu Asp Lys 
465                 470                 475                 480 


Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn 
                485                 490                 495     


Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr 
            500                 505                 510         


Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg 
        515                 520                 525             


Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly 
    530                 535                 540                 


Gly Ser Gly Gly Gly Ser Gln Glu Gly Ser Leu Pro Asp Ile Thr Ile 
545                 550                 555                 560 


Phe Pro Asn Ser Ser Leu Met Ile Ser Gln Gly Thr Phe Val Thr Val 
                565                 570                 575     


Val Cys Ser Tyr Ser Asp Lys His Asp Leu Tyr Asn Met Val Arg Leu 
            580                 585                 590         


Glu Lys Asp Gly Ser Thr Phe Met Glu Lys Ser Thr Glu Pro Tyr Lys 
        595                 600                 605             


Thr Glu Asp Glu Phe Glu Ile Gly Pro Val Asn Glu Thr Ile Thr Gly 
    610                 615                 620                 


His Tyr Ser Cys Ile Tyr Ser Lys Gly Ile Thr Trp Ser Glu Arg Ser 
625                 630                 635                 640 


Lys Thr Leu Glu Leu Lys Val Ile Lys Glu Asn Val Ile Gln Thr Pro 
                645                 650                 655     


Ala Pro Gly Pro Thr Ser Asp Thr Ser Trp Leu Lys Thr Tyr Ser Ile 
            660                 665                 670         


Tyr Gly Gly Gly Ser Gly Gly Gly Ser Glu Ala His Lys Ser Glu Ile 
        675                 680                 685             


Ala His Arg Tyr Asn Asp Leu Gly Glu Gln His Phe Lys Gly Leu Val 
    690                 695                 700                 


Leu Ile Ala Phe Ser Gln Tyr Leu Gln Lys Cys Ser Tyr Asp Glu His 
705                 710                 715                 720 


Ala Lys Leu Val Gln Glu Val Thr Asp Phe Ala Lys Thr Cys Val Ala 
                725                 730                 735     


Asp Glu Ser Ala Ala Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly 
            740                 745                 750         


Asp Lys Leu Cys Ala Ile Pro Asn Leu Arg Glu Asn Tyr Gly Glu Leu 
        755                 760                 765             


Ala Asp Cys Cys Thr Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu 
    770                 775                 780                 


Gln His Lys Asp Asp Asn Pro Ser Leu Pro Pro Phe Glu Arg Pro Glu 
785                 790                 795                 800 


Ala Glu Ala Met Cys Thr Ser Phe Lys Glu Asn Pro Thr Thr Phe Met 
                805                 810                 815     


Gly His Tyr Leu His Glu Val Ala Arg Arg His Pro Tyr Phe Tyr Ala 
            820                 825                 830         


Pro Glu Leu Leu Tyr Tyr Ala Glu Gln Tyr Asn Glu Ile Leu Thr Gln 
        835                 840                 845             


Cys Cys Ala Glu Ala Asp Lys Glu Ser Cys Leu Thr Pro Lys Leu Asp 
    850                 855                 860                 


Gly Val Lys Glu Lys Ala Leu Val Ser Ser Val Arg Gln Arg Met Lys 
865                 870                 875                 880 


Cys Ser Ser Met Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala 
                885                 890                 895     


Val Ala Arg Leu Ser Gln Thr Phe Pro Asn Ala Asp Phe Ala Glu Ile 
            900                 905                 910         


Thr Lys Leu Ala Thr Asp Leu Thr Lys Val Asn Lys Glu Cys Cys His 
        915                 920                 925             


Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Glu Leu Ala Lys Tyr 
    930                 935                 940                 


Met Cys Glu Asn Gln Ala Thr Ile Ser Ser Lys Leu Gln Thr Cys Cys 
945                 950                 955                 960 


Asp Lys Pro Leu Leu Lys Lys Ala His Cys Leu Ser Glu Val Glu His 
                965                 970                 975     


Asp Thr Met Pro Ala Asp Leu Pro Ala Ile Ala Ala Asp Phe Val Glu 
            980                 985                 990         


Asp Gln Glu Val Cys Lys Asn Tyr  Ala Glu Ala Lys Asp  Val Phe Leu 
        995                 1000                 1005             


Gly Thr  Phe Leu Tyr Glu Tyr  Ser Arg Arg His Pro  Asp Tyr Ser 
    1010                 1015                 1020             


Val Ser  Leu Leu Leu Arg Leu  Ala Lys Lys Tyr Glu  Ala Thr Leu 
    1025                 1030                 1035             


Glu Lys  Cys Cys Ala Glu Ala  Asn Pro Pro Ala Cys  Tyr Gly Thr 
    1040                 1045                 1050             


Val Leu  Ala Glu Phe Gln Pro  Leu Val Glu Glu Pro  Lys Asn Leu 
    1055                 1060                 1065             


Val Lys  Thr Asn Cys Asp Leu  Tyr Glu Lys Leu Gly  Glu Tyr Gly 
    1070                 1075                 1080             


Phe Gln  Asn Ala Ile Leu Val  Arg Tyr Thr Gln Lys  Ala Pro Gln 
    1085                 1090                 1095             


Val Ser  Thr Pro Thr Leu Val  Glu Ala Ala Arg Asn  Leu Gly Arg 
    1100                 1105                 1110             


Val Gly  Thr Lys Cys Cys Thr  Leu Pro Glu Asp Gln  Arg Leu Pro 
    1115                 1120                 1125             


Cys Val  Glu Asp Tyr Leu Ser  Ala Ile Leu Asn Arg  Val Cys Leu 
    1130                 1135                 1140             


Leu Gln  Glu Lys Thr Pro Val  Ser Glu His Val Thr  Lys Cys Cys 
    1145                 1150                 1155             


Ser Gly  Ser Leu Val Glu Arg  Arg Pro Cys Phe Ser  Ala Leu Thr 
    1160                 1165                 1170             


Val Asp  Glu Thr Tyr Val Pro  Lys Glu Phe Lys Ala  Glu Thr Phe 
    1175                 1180                 1185             


Thr Phe  His Ser Asp Ile Cys  Thr Leu Pro Glu Lys  Glu Lys Gln 
    1190                 1195                 1200             


Ile Lys  Lys Gln Thr Ala Leu  Ala Glu Leu Val Lys  His Lys Pro 
    1205                 1210                 1215             


Lys Ala  Thr Ala Glu Gln Leu  Lys Thr Val Met Asp  Asp Phe Ala 
    1220                 1225                 1230             


Gln Phe  Leu Asp Thr Cys Cys  Lys Ala Ala Asp Lys  Asp Thr Cys 
    1235                 1240                 1245             


Phe Ser  Thr Glu Gly Pro Asn  Leu Val Thr Arg Cys  Lys Asp Ala 
    1250                 1255                 1260             


Leu Ala  Gly Gly Gly Ser Ala  Pro Thr Ser Ser Ser  Thr Ser Ser 
    1265                 1270                 1275             


Ser Thr  Ala Glu Ala Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    1280                 1285                 1290             


Gln Gln  His Leu Glu Gln Leu  Leu Met Asp Leu Gln  Glu Leu Leu 
    1295                 1300                 1305             


Ser Arg  Met Glu Asn Tyr Arg  Asn Leu Lys Leu Pro  Arg Met Leu 
    1310                 1315                 1320             


Thr Phe  Lys Phe Tyr Leu Pro  Lys Gln Ala Thr Glu  Leu Lys Asp 
    1325                 1330                 1335             


Leu Gln  Cys Leu Glu Asp Glu  Leu Gly Pro Leu Arg  His Val Leu 
    1340                 1345                 1350             


Asp Leu  Thr Gln Ser Lys Ser  Phe Gln Leu Glu Asp  Ala Glu Asn 
    1355                 1360                 1365             


Phe Ile  Ser Asn Ile Arg Val  Thr Val Val Lys Leu  Lys Gly Ser 
    1370                 1375                 1380             


Asp Asn  Thr Phe Glu Cys Gln  Phe Asp Asp Glu Ser  Ala Thr Val 
    1385                 1390                 1395             


Val Asp  Phe Leu Arg Arg Trp  Ile Ala Phe Cys Gln  Ser Ile Ile 
    1400                 1405                 1410             


Ser Thr  Ser Pro Gln His His  His His His His His  His His His 
    1415                 1420                 1425             


<210> 33
<211> 1428
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr 
            20                  25                  30          


Ala Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His 
        35                  40                  45              


Leu Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu 
    50                  55                  60                  


Asn Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr 
65                  70                  75                  80  


Leu Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp 
                85                  90                  95      


Glu Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser 
            100                 105                 110         


Phe Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr 
        115                 120                 125             


Val Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp 
    130                 135                 140                 


Asp Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe 
145                 150                 155                 160 


Cys Gln Ser Ile Ile Ser Thr Ser Pro Gln Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


Gly Ser Gln Glu Gly Ser Leu Pro Asp Ile Thr Ile Phe Pro Asn Ser 
            180                 185                 190         


Ser Leu Met Ile Ser Gln Gly Thr Phe Val Thr Val Val Cys Ser Tyr 
        195                 200                 205             


Ser Asp Lys His Asp Leu Tyr Asn Met Val Arg Leu Glu Lys Asp Gly 
    210                 215                 220                 


Ser Thr Phe Met Glu Lys Ser Thr Glu Pro Tyr Lys Thr Glu Asp Glu 
225                 230                 235                 240 


Phe Glu Ile Gly Pro Val Asn Glu Thr Ile Thr Gly His Tyr Ser Cys 
                245                 250                 255     


Ile Tyr Ser Lys Gly Ile Thr Trp Ser Glu Arg Ser Lys Thr Leu Glu 
            260                 265                 270         


Leu Lys Val Ile Lys Glu Asn Val Ile Gln Thr Pro Ala Pro Gly Pro 
        275                 280                 285             


Thr Ser Asp Thr Ser Trp Leu Lys Thr Tyr Ser Ile Tyr Gly Gly Gly 
    290                 295                 300                 


Ser Gly Gly Gly Ser Glu Ala His Lys Ser Glu Ile Ala His Arg Tyr 
305                 310                 315                 320 


Asn Asp Leu Gly Glu Gln His Phe Lys Gly Leu Val Leu Ile Ala Phe 
                325                 330                 335     


Ser Gln Tyr Leu Gln Lys Cys Ser Tyr Asp Glu His Ala Lys Leu Val 
            340                 345                 350         


Gln Glu Val Thr Asp Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala 
        355                 360                 365             


Ala Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys 
    370                 375                 380                 


Ala Ile Pro Asn Leu Arg Glu Asn Tyr Gly Glu Leu Ala Asp Cys Cys 
385                 390                 395                 400 


Thr Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp 
                405                 410                 415     


Asp Asn Pro Ser Leu Pro Pro Phe Glu Arg Pro Glu Ala Glu Ala Met 
            420                 425                 430         


Cys Thr Ser Phe Lys Glu Asn Pro Thr Thr Phe Met Gly His Tyr Leu 
        435                 440                 445             


His Glu Val Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu 
    450                 455                 460                 


Tyr Tyr Ala Glu Gln Tyr Asn Glu Ile Leu Thr Gln Cys Cys Ala Glu 
465                 470                 475                 480 


Ala Asp Lys Glu Ser Cys Leu Thr Pro Lys Leu Asp Gly Val Lys Glu 
                485                 490                 495     


Lys Ala Leu Val Ser Ser Val Arg Gln Arg Met Lys Cys Ser Ser Met 
            500                 505                 510         


Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu 
        515                 520                 525             


Ser Gln Thr Phe Pro Asn Ala Asp Phe Ala Glu Ile Thr Lys Leu Ala 
    530                 535                 540                 


Thr Asp Leu Thr Lys Val Asn Lys Glu Cys Cys His Gly Asp Leu Leu 
545                 550                 555                 560 


Glu Cys Ala Asp Asp Arg Ala Glu Leu Ala Lys Tyr Met Cys Glu Asn 
                565                 570                 575     


Gln Ala Thr Ile Ser Ser Lys Leu Gln Thr Cys Cys Asp Lys Pro Leu 
            580                 585                 590         


Leu Lys Lys Ala His Cys Leu Ser Glu Val Glu His Asp Thr Met Pro 
        595                 600                 605             


Ala Asp Leu Pro Ala Ile Ala Ala Asp Phe Val Glu Asp Gln Glu Val 
    610                 615                 620                 


Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Thr Phe Leu 
625                 630                 635                 640 


Tyr Glu Tyr Ser Arg Arg His Pro Asp Tyr Ser Val Ser Leu Leu Leu 
                645                 650                 655     


Arg Leu Ala Lys Lys Tyr Glu Ala Thr Leu Glu Lys Cys Cys Ala Glu 
            660                 665                 670         


Ala Asn Pro Pro Ala Cys Tyr Gly Thr Val Leu Ala Glu Phe Gln Pro 
        675                 680                 685             


Leu Val Glu Glu Pro Lys Asn Leu Val Lys Thr Asn Cys Asp Leu Tyr 
    690                 695                 700                 


Glu Lys Leu Gly Glu Tyr Gly Phe Gln Asn Ala Ile Leu Val Arg Tyr 
705                 710                 715                 720 


Thr Gln Lys Ala Pro Gln Val Ser Thr Pro Thr Leu Val Glu Ala Ala 
                725                 730                 735     


Arg Asn Leu Gly Arg Val Gly Thr Lys Cys Cys Thr Leu Pro Glu Asp 
            740                 745                 750         


Gln Arg Leu Pro Cys Val Glu Asp Tyr Leu Ser Ala Ile Leu Asn Arg 
        755                 760                 765             


Val Cys Leu Leu His Glu Lys Thr Pro Val Ser Glu His Val Thr Lys 
    770                 775                 780                 


Cys Cys Ser Gly Ser Leu Val Glu Arg Arg Pro Cys Phe Ser Ala Leu 
785                 790                 795                 800 


Thr Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Lys Ala Glu Thr Phe 
                805                 810                 815     


Thr Phe His Ser Asp Ile Cys Thr Leu Pro Glu Lys Glu Lys Gln Ile 
            820                 825                 830         


Lys Lys Gln Thr Ala Leu Ala Glu Leu Val Lys His Lys Pro Lys Ala 
        835                 840                 845             


Thr Ala Glu Gln Leu Lys Thr Val Met Asp Asp Phe Ala Gln Phe Leu 
    850                 855                 860                 


Asp Thr Cys Cys Lys Ala Ala Asp Lys Asp Thr Cys Phe Ser Thr Glu 
865                 870                 875                 880 


Gly Pro Asn Leu Val Thr Arg Cys Lys Asp Ala Leu Ala Gly Gly Gly 
                885                 890                 895     


Ser Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp 
            900                 905                 910         


Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro 
        915                 920                 925             


Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile 
    930                 935                 940                 


Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala 
945                 950                 955                 960 


Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His 
                965                 970                 975     


Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu 
            980                 985                 990         


Lys Asn Phe Lys Asn Lys Thr Phe  Leu Lys Cys Glu Ala  Pro Asn Tyr 
        995                 1000                 1005             


Ser Gly  Arg Phe Thr Cys Ser  Trp Leu Val Gln Arg  Asn Met Asp 
    1010                 1015                 1020             


Leu Lys  Phe Asn Ile Lys Ser  Ser Ser Ser Ser Pro  Asp Ser Arg 
    1025                 1030                 1035             


Ala Val  Thr Cys Gly Met Ala  Ser Leu Ser Ala Glu  Lys Val Thr 
    1040                 1045                 1050             


Leu Asp  Gln Arg Asp Tyr Glu  Lys Tyr Ser Val Ser  Cys Gln Glu 
    1055                 1060                 1065             


Asp Val  Thr Cys Pro Thr Ala  Glu Glu Thr Leu Pro  Ile Glu Leu 
    1070                 1075                 1080             


Ala Leu  Glu Ala Arg Gln Gln  Asn Lys Tyr Glu Asn  Tyr Ser Thr 
    1085                 1090                 1095             


Ser Phe  Phe Ile Arg Asp Ile  Ile Lys Pro Asp Pro  Pro Lys Asn 
    1100                 1105                 1110             


Leu Gln  Met Lys Pro Leu Lys  Asn Ser Gln Val Glu  Val Ser Trp 
    1115                 1120                 1125             


Glu Tyr  Pro Asp Ser Trp Ser  Thr Pro His Ser Tyr  Phe Ser Leu 
    1130                 1135                 1140             


Lys Phe  Phe Val Arg Ile Gln  Arg Lys Lys Glu Lys  Met Lys Glu 
    1145                 1150                 1155             


Thr Glu  Glu Gly Cys Asn Gln  Lys Gly Ala Phe Leu  Val Glu Lys 
    1160                 1165                 1170             


Thr Ser  Thr Glu Val Gln Cys  Lys Gly Gly Asn Val  Cys Val Gln 
    1175                 1180                 1185             


Ala Gln  Asp Arg Tyr Tyr Asn  Ser Ser Cys Ser Lys  Trp Ala Cys 
    1190                 1195                 1200             


Val Pro  Cys Arg Val Arg Ser  Gly Gly Ser Gly Gly  Gly Ser Gly 
    1205                 1210                 1215             


Gly Gly  Ser Gly Gly Gly Ser  Arg Val Ile Pro Val  Ser Gly Pro 
    1220                 1225                 1230             


Ala Arg  Cys Leu Ser Gln Ser  Arg Asn Leu Leu Lys  Thr Thr Asp 
    1235                 1240                 1245             


Asp Met  Val Lys Thr Ala Arg  Glu Lys Leu Lys His  Tyr Ser Cys 
    1250                 1255                 1260             


Thr Ala  Glu Asp Ile Asp His  Glu Asp Ile Thr Arg  Asp Gln Thr 
    1265                 1270                 1275             


Ser Thr  Leu Lys Thr Cys Leu  Pro Leu Glu Leu His  Lys Asn Glu 
    1280                 1285                 1290             


Ser Cys  Leu Ala Thr Arg Glu  Thr Ser Ser Thr Thr  Arg Gly Ser 
    1295                 1300                 1305             


Cys Leu  Pro Pro Gln Lys Thr  Ser Leu Met Met Thr  Leu Cys Leu 
    1310                 1315                 1320             


Gly Ser  Ile Tyr Glu Asp Leu  Lys Met Tyr Gln Thr  Glu Phe Gln 
    1325                 1330                 1335             


Ala Ile  Asn Ala Ala Leu Gln  Asn His Asn His Gln  Gln Ile Ile 
    1340                 1345                 1350             


Leu Asp  Lys Gly Met Leu Val  Ala Ile Asp Glu Leu  Met Gln Ser 
    1355                 1360                 1365             


Leu Asn  His Asn Gly Glu Thr  Leu Arg Gln Lys Pro  Pro Val Gly 
    1370                 1375                 1380             


Glu Ala  Asp Pro Tyr Arg Val  Lys Met Lys Leu Cys  Ile Leu Leu 
    1385                 1390                 1395             


His Ala  Phe Ser Thr Arg Val  Val Thr Ile Asn Arg  Val Met Gly 
    1400                 1405                 1410             


Tyr Leu  Ser Ser Ala His His  His His His His His  His His His 
    1415                 1420                 1425             


<210> 34
<211> 1428
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr 
            20                  25                  30          


Ala Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His 
        35                  40                  45              


Leu Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu 
    50                  55                  60                  


Asn Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr 
65                  70                  75                  80  


Leu Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp 
                85                  90                  95      


Glu Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser 
            100                 105                 110         


Phe Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr 
        115                 120                 125             


Val Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp 
    130                 135                 140                 


Asp Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe 
145                 150                 155                 160 


Cys Gln Ser Ile Ile Ser Thr Ser Pro Gln Gly Gly Gly Ser Glu Ala 
                165                 170                 175     


His Lys Ser Glu Ile Ala His Arg Tyr Asn Asp Leu Gly Glu Gln His 
            180                 185                 190         


Phe Lys Gly Leu Val Leu Ile Ala Phe Ser Gln Tyr Leu Gln Lys Cys 
        195                 200                 205             


Ser Tyr Asp Glu His Ala Lys Leu Val Gln Glu Val Thr Asp Phe Ala 
    210                 215                 220                 


Lys Thr Cys Val Ala Asp Glu Ser Ala Ala Asn Cys Asp Lys Ser Leu 
225                 230                 235                 240 


His Thr Leu Phe Gly Asp Lys Leu Cys Ala Ile Pro Asn Leu Arg Glu 
                245                 250                 255     


Asn Tyr Gly Glu Leu Ala Asp Cys Cys Thr Lys Gln Glu Pro Glu Arg 
            260                 265                 270         


Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Ser Leu Pro Pro 
        275                 280                 285             


Phe Glu Arg Pro Glu Ala Glu Ala Met Cys Thr Ser Phe Lys Glu Asn 
    290                 295                 300                 


Pro Thr Thr Phe Met Gly His Tyr Leu His Glu Val Ala Arg Arg His 
305                 310                 315                 320 


Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Tyr Tyr Ala Glu Gln Tyr Asn 
                325                 330                 335     


Glu Ile Leu Thr Gln Cys Cys Ala Glu Ala Asp Lys Glu Ser Cys Leu 
            340                 345                 350         


Thr Pro Lys Leu Asp Gly Val Lys Glu Lys Ala Leu Val Ser Ser Val 
        355                 360                 365             


Arg Gln Arg Met Lys Cys Ser Ser Met Gln Lys Phe Gly Glu Arg Ala 
    370                 375                 380                 


Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Thr Phe Pro Asn Ala 
385                 390                 395                 400 


Asp Phe Ala Glu Ile Thr Lys Leu Ala Thr Asp Leu Thr Lys Val Asn 
                405                 410                 415     


Lys Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala 
            420                 425                 430         


Glu Leu Ala Lys Tyr Met Cys Glu Asn Gln Ala Thr Ile Ser Ser Lys 
        435                 440                 445             


Leu Gln Thr Cys Cys Asp Lys Pro Leu Leu Lys Lys Ala His Cys Leu 
    450                 455                 460                 


Ser Glu Val Glu His Asp Thr Met Pro Ala Asp Leu Pro Ala Ile Ala 
465                 470                 475                 480 


Ala Asp Phe Val Glu Asp Gln Glu Val Cys Lys Asn Tyr Ala Glu Ala 
                485                 490                 495     


Lys Asp Val Phe Leu Gly Thr Phe Leu Tyr Glu Tyr Ser Arg Arg His 
            500                 505                 510         


Pro Asp Tyr Ser Val Ser Leu Leu Leu Arg Leu Ala Lys Lys Tyr Glu 
        515                 520                 525             


Ala Thr Leu Glu Lys Cys Cys Ala Glu Ala Asn Pro Pro Ala Cys Tyr 
    530                 535                 540                 


Gly Thr Val Leu Ala Glu Phe Gln Pro Leu Val Glu Glu Pro Lys Asn 
545                 550                 555                 560 


Leu Val Lys Thr Asn Cys Asp Leu Tyr Glu Lys Leu Gly Glu Tyr Gly 
                565                 570                 575     


Phe Gln Asn Ala Ile Leu Val Arg Tyr Thr Gln Lys Ala Pro Gln Val 
            580                 585                 590         


Ser Thr Pro Thr Leu Val Glu Ala Ala Arg Asn Leu Gly Arg Val Gly 
        595                 600                 605             


Thr Lys Cys Cys Thr Leu Pro Glu Asp Gln Arg Leu Pro Cys Val Glu 
    610                 615                 620                 


Asp Tyr Leu Ser Ala Ile Leu Asn Arg Val Cys Leu Leu His Glu Lys 
625                 630                 635                 640 


Thr Pro Val Ser Glu His Val Thr Lys Cys Cys Ser Gly Ser Leu Val 
                645                 650                 655     


Glu Arg Arg Pro Cys Phe Ser Ala Leu Thr Val Asp Glu Thr Tyr Val 
            660                 665                 670         


Pro Lys Glu Phe Lys Ala Glu Thr Phe Thr Phe His Ser Asp Ile Cys 
        675                 680                 685             


Thr Leu Pro Glu Lys Glu Lys Gln Ile Lys Lys Gln Thr Ala Leu Ala 
    690                 695                 700                 


Glu Leu Val Lys His Lys Pro Lys Ala Thr Ala Glu Gln Leu Lys Thr 
705                 710                 715                 720 


Val Met Asp Asp Phe Ala Gln Phe Leu Asp Thr Cys Cys Lys Ala Ala 
                725                 730                 735     


Asp Lys Asp Thr Cys Phe Ser Thr Glu Gly Pro Asn Leu Val Thr Arg 
            740                 745                 750         


Cys Lys Asp Ala Leu Ala Gly Gly Gly Ser Gly Gly Gly Ser Gln Glu 
        755                 760                 765             


Gly Ser Leu Pro Asp Ile Thr Ile Phe Pro Asn Ser Ser Leu Met Ile 
    770                 775                 780                 


Ser Gln Gly Thr Phe Val Thr Val Val Cys Ser Tyr Ser Asp Lys His 
785                 790                 795                 800 


Asp Leu Tyr Asn Met Val Arg Leu Glu Lys Asp Gly Ser Thr Phe Met 
                805                 810                 815     


Glu Lys Ser Thr Glu Pro Tyr Lys Thr Glu Asp Glu Phe Glu Ile Gly 
            820                 825                 830         


Pro Val Asn Glu Thr Ile Thr Gly His Tyr Ser Cys Ile Tyr Ser Lys 
        835                 840                 845             


Gly Ile Thr Trp Ser Glu Arg Ser Lys Thr Leu Glu Leu Lys Val Ile 
    850                 855                 860                 


Lys Glu Asn Val Ile Gln Thr Pro Ala Pro Gly Pro Thr Ser Asp Thr 
865                 870                 875                 880 


Ser Trp Leu Lys Thr Tyr Ser Ile Tyr Gly Gly Gly Ser Gly Gly Gly 
                885                 890                 895     


Ser Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp 
            900                 905                 910         


Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro 
        915                 920                 925             


Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile 
    930                 935                 940                 


Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala 
945                 950                 955                 960 


Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His 
                965                 970                 975     


Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu 
            980                 985                 990         


Lys Asn Phe Lys Asn Lys Thr Phe  Leu Lys Cys Glu Ala  Pro Asn Tyr 
        995                 1000                 1005             


Ser Gly  Arg Phe Thr Cys Ser  Trp Leu Val Gln Arg  Asn Met Asp 
    1010                 1015                 1020             


Leu Lys  Phe Asn Ile Lys Ser  Ser Ser Ser Ser Pro  Asp Ser Arg 
    1025                 1030                 1035             


Ala Val  Thr Cys Gly Met Ala  Ser Leu Ser Ala Glu  Lys Val Thr 
    1040                 1045                 1050             


Leu Asp  Gln Arg Asp Tyr Glu  Lys Tyr Ser Val Ser  Cys Gln Glu 
    1055                 1060                 1065             


Asp Val  Thr Cys Pro Thr Ala  Glu Glu Thr Leu Pro  Ile Glu Leu 
    1070                 1075                 1080             


Ala Leu  Glu Ala Arg Gln Gln  Asn Lys Tyr Glu Asn  Tyr Ser Thr 
    1085                 1090                 1095             


Ser Phe  Phe Ile Arg Asp Ile  Ile Lys Pro Asp Pro  Pro Lys Asn 
    1100                 1105                 1110             


Leu Gln  Met Lys Pro Leu Lys  Asn Ser Gln Val Glu  Val Ser Trp 
    1115                 1120                 1125             


Glu Tyr  Pro Asp Ser Trp Ser  Thr Pro His Ser Tyr  Phe Ser Leu 
    1130                 1135                 1140             


Lys Phe  Phe Val Arg Ile Gln  Arg Lys Lys Glu Lys  Met Lys Glu 
    1145                 1150                 1155             


Thr Glu  Glu Gly Cys Asn Gln  Lys Gly Ala Phe Leu  Val Glu Lys 
    1160                 1165                 1170             


Thr Ser  Thr Glu Val Gln Cys  Lys Gly Gly Asn Val  Cys Val Gln 
    1175                 1180                 1185             


Ala Gln  Asp Arg Tyr Tyr Asn  Ser Ser Cys Ser Lys  Trp Ala Cys 
    1190                 1195                 1200             


Val Pro  Cys Arg Val Arg Ser  Gly Gly Ser Gly Gly  Gly Ser Gly 
    1205                 1210                 1215             


Gly Gly  Ser Gly Gly Gly Ser  Arg Val Ile Pro Val  Ser Gly Pro 
    1220                 1225                 1230             


Ala Arg  Cys Leu Ser Gln Ser  Arg Asn Leu Leu Lys  Thr Thr Asp 
    1235                 1240                 1245             


Asp Met  Val Lys Thr Ala Arg  Glu Lys Leu Lys His  Tyr Ser Cys 
    1250                 1255                 1260             


Thr Ala  Glu Asp Ile Asp His  Glu Asp Ile Thr Arg  Asp Gln Thr 
    1265                 1270                 1275             


Ser Thr  Leu Lys Thr Cys Leu  Pro Leu Glu Leu His  Lys Asn Glu 
    1280                 1285                 1290             


Ser Cys  Leu Ala Thr Arg Glu  Thr Ser Ser Thr Thr  Arg Gly Ser 
    1295                 1300                 1305             


Cys Leu  Pro Pro Gln Lys Thr  Ser Leu Met Met Thr  Leu Cys Leu 
    1310                 1315                 1320             


Gly Ser  Ile Tyr Glu Asp Leu  Lys Met Tyr Gln Thr  Glu Phe Gln 
    1325                 1330                 1335             


Ala Ile  Asn Ala Ala Leu Gln  Asn His Asn His Gln  Gln Ile Ile 
    1340                 1345                 1350             


Leu Asp  Lys Gly Met Leu Val  Ala Ile Asp Glu Leu  Met Gln Ser 
    1355                 1360                 1365             


Leu Asn  His Asn Gly Glu Thr  Leu Arg Gln Lys Pro  Pro Val Gly 
    1370                 1375                 1380             


Glu Ala  Asp Pro Tyr Arg Val  Lys Met Lys Leu Cys  Ile Leu Leu 
    1385                 1390                 1395             


His Ala  Phe Ser Thr Arg Val  Val Thr Ile Asn Arg  Val Met Gly 
    1400                 1405                 1410             


Tyr Leu  Ser Ser Ala His His  His His His His His  His His His 
    1415                 1420                 1425             


<210> 35
<211> 959
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 35
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr 
            20                  25                  30          


Ala Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His 
        35                  40                  45              


Leu Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu 
    50                  55                  60                  


Asn Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr 
65                  70                  75                  80  


Leu Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp 
                85                  90                  95      


Glu Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser 
            100                 105                 110         


Phe Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr 
        115                 120                 125             


Val Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp 
    130                 135                 140                 


Asp Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe 
145                 150                 155                 160 


Cys Gln Ser Ile Ile Ser Thr Ser Pro Gln Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


Gly Ser Gln Glu Gly Ser Leu Pro Asp Ile Thr Ile Phe Pro Asn Ser 
            180                 185                 190         


Ser Leu Met Ile Ser Gln Gly Thr Phe Val Thr Val Val Cys Ser Tyr 
        195                 200                 205             


Ser Asp Lys His Asp Leu Tyr Asn Met Val Arg Leu Glu Lys Asp Gly 
    210                 215                 220                 


Ser Thr Phe Met Glu Lys Ser Thr Glu Pro Tyr Lys Thr Glu Asp Glu 
225                 230                 235                 240 


Phe Glu Ile Gly Pro Val Asn Glu Thr Ile Thr Gly His Tyr Ser Cys 
                245                 250                 255     


Ile Tyr Ser Lys Gly Ile Thr Trp Ser Glu Arg Ser Lys Thr Leu Glu 
            260                 265                 270         


Leu Lys Val Ile Lys Glu Asn Val Ile Gln Thr Pro Ala Pro Gly Pro 
        275                 280                 285             


Thr Ser Asp Thr Ser Trp Leu Lys Thr Tyr Ser Ile Tyr Gly Gly Gly 
    290                 295                 300                 


Ser Gly Gly Gly Ser Lys Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
305                 310                 315                 320 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                325                 330                 335     


Thr Phe Ser Ser Phe Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys 
            340                 345                 350         


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu 
        355                 360                 365             


Tyr Ala Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
    370                 375                 380                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
385                 390                 395                 400 


Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Pro Ser Ser Gln 
                405                 410                 415     


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Met Trp Glu Leu 
            420                 425                 430         


Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr Pro Asp Ala Pro 
        435                 440                 445             


Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu Glu Asp Asp Ile 
    450                 455                 460                 


Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly Ser Gly Lys Thr 
465                 470                 475                 480 


Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly Gln Tyr Thr Cys 
                485                 490                 495     


His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu Leu Leu His Lys 
            500                 505                 510         


Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys Asn Phe Lys Asn 
        515                 520                 525             


Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser Gly Arg Phe Thr 
    530                 535                 540                 


Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys Phe Asn Ile Lys 
545                 550                 555                 560 


Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr Cys Gly Met Ala 
                565                 570                 575     


Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg Asp Tyr Glu Lys 
            580                 585                 590         


Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro Thr Ala Glu Glu 
        595                 600                 605             


Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln Gln Asn Lys Tyr 
    610                 615                 620                 


Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp 
625                 630                 635                 640 


Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn Ser Gln Val Glu 
                645                 650                 655     


Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro His Ser Tyr Phe 
            660                 665                 670         


Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys Glu Lys Met Lys 
        675                 680                 685             


Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe Leu Val Glu Lys 
    690                 695                 700                 


Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val Cys Val Gln Ala 
705                 710                 715                 720 


Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp Ala Cys Val Pro 
                725                 730                 735     


Cys Arg Val Arg Ser Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu 
        755                 760                 765             


Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr 
    770                 775                 780                 


Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp 
785                 790                 795                 800 


His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu 
                805                 810                 815     


Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr 
            820                 825                 830         


Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu 
        835                 840                 845             


Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
    850                 855                 860                 


Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His 
865                 870                 875                 880 


Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu 
                885                 890                 895     


Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro 
            900                 905                 910         


Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu 
        915                 920                 925             


Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly 
    930                 935                 940                 


Tyr Leu Ser Ser Ala His His His His His His His His His His 
945                 950                 955                 


<210> 36
<211> 959
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 36
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr 
            20                  25                  30          


Ala Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His 
        35                  40                  45              


Leu Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu 
    50                  55                  60                  


Asn Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr 
65                  70                  75                  80  


Leu Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp 
                85                  90                  95      


Glu Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser 
            100                 105                 110         


Phe Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr 
        115                 120                 125             


Val Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp 
    130                 135                 140                 


Asp Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe 
145                 150                 155                 160 


Cys Gln Ser Ile Ile Ser Thr Ser Pro Gln Gly Gly Gly Ser Lys Val 
                165                 170                 175     


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
            180                 185                 190         


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
        195                 200                 205             


Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
    210                 215                 220                 


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Arg Gly 
225                 230                 235                 240 


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
                245                 250                 255     


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
            260                 265                 270         


Gly Gly Ser Leu Ser Pro Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
        275                 280                 285             


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Glu Gly Ser Leu Pro Asp 
    290                 295                 300                 


Ile Thr Ile Phe Pro Asn Ser Ser Leu Met Ile Ser Gln Gly Thr Phe 
305                 310                 315                 320 


Val Thr Val Val Cys Ser Tyr Ser Asp Lys His Asp Leu Tyr Asn Met 
                325                 330                 335     


Val Arg Leu Glu Lys Asp Gly Ser Thr Phe Met Glu Lys Ser Thr Glu 
            340                 345                 350         


Pro Tyr Lys Thr Glu Asp Glu Phe Glu Ile Gly Pro Val Asn Glu Thr 
        355                 360                 365             


Ile Thr Gly His Tyr Ser Cys Ile Tyr Ser Lys Gly Ile Thr Trp Ser 
    370                 375                 380                 


Glu Arg Ser Lys Thr Leu Glu Leu Lys Val Ile Lys Glu Asn Val Ile 
385                 390                 395                 400 


Gln Thr Pro Ala Pro Gly Pro Thr Ser Asp Thr Ser Trp Leu Lys Thr 
                405                 410                 415     


Tyr Ser Ile Tyr Gly Gly Gly Ser Gly Gly Gly Ser Met Trp Glu Leu 
            420                 425                 430         


Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr Pro Asp Ala Pro 
        435                 440                 445             


Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu Glu Asp Asp Ile 
    450                 455                 460                 


Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly Ser Gly Lys Thr 
465                 470                 475                 480 


Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly Gln Tyr Thr Cys 
                485                 490                 495     


His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu Leu Leu His Lys 
            500                 505                 510         


Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys Asn Phe Lys Asn 
        515                 520                 525             


Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser Gly Arg Phe Thr 
    530                 535                 540                 


Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys Phe Asn Ile Lys 
545                 550                 555                 560 


Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr Cys Gly Met Ala 
                565                 570                 575     


Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg Asp Tyr Glu Lys 
            580                 585                 590         


Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro Thr Ala Glu Glu 
        595                 600                 605             


Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln Gln Asn Lys Tyr 
    610                 615                 620                 


Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp 
625                 630                 635                 640 


Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn Ser Gln Val Glu 
                645                 650                 655     


Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro His Ser Tyr Phe 
            660                 665                 670         


Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys Glu Lys Met Lys 
        675                 680                 685             


Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe Leu Val Glu Lys 
    690                 695                 700                 


Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val Cys Val Gln Ala 
705                 710                 715                 720 


Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp Ala Cys Val Pro 
                725                 730                 735     


Cys Arg Val Arg Ser Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu 
        755                 760                 765             


Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr 
    770                 775                 780                 


Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp 
785                 790                 795                 800 


His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu 
                805                 810                 815     


Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr 
            820                 825                 830         


Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu 
        835                 840                 845             


Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
    850                 855                 860                 


Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His 
865                 870                 875                 880 


Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu 
                885                 890                 895     


Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro 
            900                 905                 910         


Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu 
        915                 920                 925             


Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly 
    930                 935                 940                 


Tyr Leu Ser Ser Ala His His His His His His His His His His 
945                 950                 955                 


<210> 37
<211> 1435
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 37
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val 
            20                  25                  30          


Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr 
        35                  40                  45              


Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg 
    50                  55                  60                  


His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu 
65                  70                  75                  80  


Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu 
                85                  90                  95      


Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser 
            100                 105                 110         


Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu 
        115                 120                 125             


Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg 
    130                 135                 140                 


Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp 
145                 150                 155                 160 


Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val 
                165                 170                 175     


Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu 
            180                 185                 190         


Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala 
        195                 200                 205             


Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe 
    210                 215                 220                 


Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met 
225                 230                 235                 240 


Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp 
                245                 250                 255     


Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg 
            260                 265                 270         


Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn 
        275                 280                 285             


Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys 
    290                 295                 300                 


Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser 
305                 310                 315                 320 


Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly 
                325                 330                 335     


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Val Ile 
            340                 345                 350         


Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu 
        355                 360                 365             


Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys Leu Lys His 
    370                 375                 380                 


Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp 
385                 390                 395                 400 


Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn 
                405                 410                 415     


Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser 
            420                 425                 430         


Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly 
        435                 440                 445             


Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile 
    450                 455                 460                 


Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile Leu Asp Lys 
465                 470                 475                 480 


Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn 
                485                 490                 495     


Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr 
            500                 505                 510         


Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg 
        515                 520                 525             


Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly 
    530                 535                 540                 


Gly Gly Ser Gly Gly Gly Ser Gln Glu Gly Ser Leu Pro Asp Ile Thr 
545                 550                 555                 560 


Ile Phe Pro Asn Ser Ser Leu Met Ile Ser Gln Gly Thr Phe Val Thr 
                565                 570                 575     


Val Val Cys Ser Tyr Ser Asp Lys His Asp Leu Tyr Asn Met Val Arg 
            580                 585                 590         


Leu Glu Lys Asp Gly Ser Thr Phe Met Glu Lys Ser Thr Glu Pro Tyr 
        595                 600                 605             


Lys Thr Glu Asp Glu Phe Glu Ile Gly Pro Val Asn Glu Thr Ile Thr 
    610                 615                 620                 


Gly His Tyr Ser Cys Ile Tyr Ser Lys Gly Ile Thr Trp Ser Glu Arg 
625                 630                 635                 640 


Ser Lys Thr Leu Glu Leu Lys Val Ile Lys Glu Asn Val Ile Gln Thr 
                645                 650                 655     


Pro Ala Pro Gly Pro Thr Ser Asp Thr Ser Trp Leu Lys Thr Tyr Ser 
            660                 665                 670         


Ile Tyr Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Ala His Lys Ser 
        675                 680                 685             


Glu Ile Ala His Arg Tyr Asn Asp Leu Gly Glu Gln His Phe Lys Gly 
    690                 695                 700                 


Leu Val Leu Ile Ala Phe Ser Gln Tyr Leu Gln Lys Cys Ser Tyr Asp 
705                 710                 715                 720 


Glu His Ala Lys Leu Val Gln Glu Val Thr Asp Phe Ala Lys Thr Cys 
                725                 730                 735     


Val Ala Asp Glu Ser Ala Ala Asn Cys Asp Lys Ser Leu His Thr Leu 
            740                 745                 750         


Phe Gly Asp Lys Leu Cys Ala Ile Pro Asn Leu Arg Glu Asn Tyr Gly 
        755                 760                 765             


Glu Leu Ala Asp Cys Cys Thr Lys Gln Glu Pro Glu Arg Asn Glu Cys 
    770                 775                 780                 


Phe Leu Gln His Lys Asp Asp Asn Pro Ser Leu Pro Pro Phe Glu Arg 
785                 790                 795                 800 


Pro Glu Ala Glu Ala Met Cys Thr Ser Phe Lys Glu Asn Pro Thr Thr 
                805                 810                 815     


Phe Met Gly His Tyr Leu His Glu Val Ala Arg Arg His Pro Tyr Phe 
            820                 825                 830         


Tyr Ala Pro Glu Leu Leu Tyr Tyr Ala Glu Gln Tyr Asn Glu Ile Leu 
        835                 840                 845             


Thr Gln Cys Cys Ala Glu Ala Asp Lys Glu Ser Cys Leu Thr Pro Lys 
    850                 855                 860                 


Leu Asp Gly Val Lys Glu Lys Ala Leu Val Ser Ser Val Arg Gln Arg 
865                 870                 875                 880 


Met Lys Cys Ser Ser Met Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala 
                885                 890                 895     


Trp Ala Val Ala Arg Leu Ser Gln Thr Phe Pro Asn Ala Asp Phe Ala 
            900                 905                 910         


Glu Ile Thr Lys Leu Ala Thr Asp Leu Thr Lys Val Asn Lys Glu Cys 
        915                 920                 925             


Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Glu Leu Ala 
    930                 935                 940                 


Lys Tyr Met Cys Glu Asn Gln Ala Thr Ile Ser Ser Lys Leu Gln Thr 
945                 950                 955                 960 


Cys Cys Asp Lys Pro Leu Leu Lys Lys Ala His Cys Leu Ser Glu Val 
                965                 970                 975     


Glu His Asp Thr Met Pro Ala Asp Leu Pro Ala Ile Ala Ala Asp Phe 
            980                 985                 990         


Val Glu Asp Gln Glu Val Cys Lys  Asn Tyr Ala Glu Ala  Lys Asp Val 
        995                 1000                 1005             


Phe Leu  Gly Thr Phe Leu Tyr  Glu Tyr Ser Arg Arg  His Pro Asp 
    1010                 1015                 1020             


Tyr Ser  Val Ser Leu Leu Leu  Arg Leu Ala Lys Lys  Tyr Glu Ala 
    1025                 1030                 1035             


Thr Leu  Glu Lys Cys Cys Ala  Glu Ala Asn Pro Pro  Ala Cys Tyr 
    1040                 1045                 1050             


Gly Thr  Val Leu Ala Glu Phe  Gln Pro Leu Val Glu  Glu Pro Lys 
    1055                 1060                 1065             


Asn Leu  Val Lys Thr Asn Cys  Asp Leu Tyr Glu Lys  Leu Gly Glu 
    1070                 1075                 1080             


Tyr Gly  Phe Gln Asn Ala Ile  Leu Val Arg Tyr Thr  Gln Lys Ala 
    1085                 1090                 1095             


Pro Gln  Val Ser Thr Pro Thr  Leu Val Glu Ala Ala  Arg Asn Leu 
    1100                 1105                 1110             


Gly Arg  Val Gly Thr Lys Cys  Cys Thr Leu Pro Glu  Asp Gln Arg 
    1115                 1120                 1125             


Leu Pro  Cys Val Glu Asp Tyr  Leu Ser Ala Ile Leu  Asn Arg Val 
    1130                 1135                 1140             


Cys Leu  Leu His Glu Lys Thr  Pro Val Ser Glu His  Val Thr Lys 
    1145                 1150                 1155             


Cys Cys  Ser Gly Ser Leu Val  Glu Arg Arg Pro Cys  Phe Ser Ala 
    1160                 1165                 1170             


Leu Thr  Val Asp Glu Thr Tyr  Val Pro Lys Glu Phe  Lys Ala Glu 
    1175                 1180                 1185             


Thr Phe  Thr Phe His Ser Asp  Ile Cys Thr Leu Pro  Glu Lys Glu 
    1190                 1195                 1200             


Lys Gln  Ile Lys Lys Gln Thr  Ala Leu Ala Glu Leu  Val Lys His 
    1205                 1210                 1215             


Lys Pro  Lys Ala Thr Ala Glu  Gln Leu Lys Thr Val  Met Asp Asp 
    1220                 1225                 1230             


Phe Ala  Gln Phe Leu Asp Thr  Cys Cys Lys Ala Ala  Asp Lys Asp 
    1235                 1240                 1245             


Thr Cys  Phe Ser Thr Glu Gly  Pro Asn Leu Val Thr  Arg Cys Lys 
    1250                 1255                 1260             


Asp Ala  Leu Ala Gly Gly Gly  Gly Ser Gly Gly Gly  Ser Ala Pro 
    1265                 1270                 1275             


Thr Ser  Ser Ser Thr Ser Ser  Ser Thr Ala Glu Ala  Gln Gln Gln 
    1280                 1285                 1290             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln His Leu Glu  Gln Leu Leu 
    1295                 1300                 1305             


Met Asp  Leu Gln Glu Leu Leu  Ser Arg Met Glu Asn  Tyr Arg Asn 
    1310                 1315                 1320             


Leu Lys  Leu Pro Arg Met Leu  Thr Phe Lys Phe Tyr  Leu Pro Lys 
    1325                 1330                 1335             


Gln Ala  Thr Glu Leu Lys Asp  Leu Gln Cys Leu Glu  Asp Glu Leu 
    1340                 1345                 1350             


Gly Pro  Leu Arg His Val Leu  Asp Leu Thr Gln Ser  Lys Ser Phe 
    1355                 1360                 1365             


Gln Leu  Glu Asp Ala Glu Asn  Phe Ile Ser Asn Ile  Arg Val Thr 
    1370                 1375                 1380             


Val Val  Lys Leu Lys Gly Ser  Asp Asn Thr Phe Glu  Cys Gln Phe 
    1385                 1390                 1395             


Asp Asp  Glu Ser Ala Thr Val  Val Asp Phe Leu Arg  Arg Trp Ile 
    1400                 1405                 1410             


Ala Phe  Cys Gln Ser Ile Ile  Ser Thr Ser Pro Gln  His His His 
    1415                 1420                 1425             


His His  His His His His His  
    1430                 1435 


<210> 38
<211> 1431
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val 
            20                  25                  30          


Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr 
        35                  40                  45              


Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser 
    50                  55                  60                  


Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu 
65                  70                  75                  80  


Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu 
                85                  90                  95      


Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser 
            100                 105                 110         


Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu 
        115                 120                 125             


Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu 
    130                 135                 140                 


Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly 
145                 150                 155                 160 


Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala 
                165                 170                 175     


Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys 
            180                 185                 190         


Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu 
        195                 200                 205             


Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser 
    210                 215                 220                 


Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu 
225                 230                 235                 240 


Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu 
                245                 250                 255     


Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe 
            260                 265                 270         


Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val 
        275                 280                 285             


Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser 
    290                 295                 300                 


Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu 
305                 310                 315                 320 


Trp Ala Ser Val Pro Cys Ser Gly Gly Ser Gly Gly Gly Ser Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            340                 345                 350         


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        355                 360                 365             


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    370                 375                 380                 


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
385                 390                 395                 400 


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                405                 410                 415     


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            420                 425                 430         


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        435                 440                 445             


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    450                 455                 460                 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
465                 470                 475                 480 


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                485                 490                 495     


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            500                 505                 510         


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        515                 520                 525             


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Gly Ser Gly 
    530                 535                 540                 


Gly Gly Ser Gln Glu Glu Asp Leu Pro Arg Pro Ser Ile Ser Ala Glu 
545                 550                 555                 560 


Pro Gly Thr Val Ile Pro Leu Gly Ser His Val Thr Phe Val Cys Arg 
                565                 570                 575     


Gly Pro Val Gly Val Gln Thr Phe Arg Leu Glu Arg Glu Ser Arg Ser 
            580                 585                 590         


Thr Tyr Asn Asp Thr Glu Asp Val Ser Gln Ala Ser Pro Ser Glu Ser 
        595                 600                 605             


Glu Ala Arg Phe Arg Ile Asp Ser Val Ser Glu Gly Asn Ala Gly Pro 
    610                 615                 620                 


Tyr Arg Cys Ile Tyr Tyr Lys Pro Pro Lys Trp Ser Glu Gln Ser Asp 
625                 630                 635                 640 


Tyr Leu Glu Leu Leu Val Lys Glu Thr Ser Gly Gly Pro Asp Ser Pro 
                645                 650                 655     


Asp Thr Glu Pro Gly Ser Ser Ala Gly Pro Thr Gln Arg Pro Ser Asp 
            660                 665                 670         


Asn Ser His Asn Glu His Ala Pro Ala Ser Gln Gly Leu Lys Ala Glu 
        675                 680                 685             


His Leu Tyr Gly Gly Gly Ser Gly Gly Gly Ser Asp Ala His Lys Ser 
    690                 695                 700                 


Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala 
705                 710                 715                 720 


Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu 
                725                 730                 735     


Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys 
            740                 745                 750         


Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu 
        755                 760                 765             


Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly 
    770                 775                 780                 


Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys 
785                 790                 795                 800 


Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg 
                805                 810                 815     


Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr 
            820                 825                 830         


Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe 
        835                 840                 845             


Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe 
    850                 855                 860                 


Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys 
865                 870                 875                 880 


Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg 
                885                 890                 895     


Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala 
            900                 905                 910         


Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala 
        915                 920                 925             


Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys 
    930                 935                 940                 


Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala 
945                 950                 955                 960 


Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu 
                965                 970                 975     


Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val 
            980                 985                 990         


Glu Asn Asp Glu Met Pro Ala Asp  Leu Pro Ser Leu Ala  Ala Asp Phe 
        995                 1000                 1005             


Val Glu  Ser Lys Asp Val Cys  Lys Asn Tyr Ala Glu  Ala Lys Asp 
    1010                 1015                 1020             


Val Phe  Leu Gly Met Phe Leu  Tyr Glu Tyr Ala Arg  Arg His Pro 
    1025                 1030                 1035             


Asp Tyr  Ser Val Val Leu Leu  Leu Arg Leu Ala Lys  Thr Tyr Glu 
    1040                 1045                 1050             


Thr Thr  Leu Glu Lys Cys Cys  Ala Ala Ala Asp Pro  His Glu Cys 
    1055                 1060                 1065             


Tyr Ala  Lys Val Phe Asp Glu  Phe Lys Pro Leu Val  Glu Glu Pro 
    1070                 1075                 1080             


Gln Asn  Leu Ile Lys Gln Asn  Cys Glu Leu Phe Glu  Gln Leu Gly 
    1085                 1090                 1095             


Glu Tyr  Lys Phe Gln Asn Ala  Leu Leu Val Arg Tyr  Thr Lys Lys 
    1100                 1105                 1110             


Val Pro  Gln Val Ser Thr Pro  Thr Leu Val Glu Val  Ser Arg Asn 
    1115                 1120                 1125             


Leu Gly  Lys Val Gly Ser Lys  Cys Cys Lys His Pro  Glu Ala Lys 
    1130                 1135                 1140             


Arg Met  Pro Cys Ala Glu Asp  Tyr Leu Ser Val Val  Leu Asn Gln 
    1145                 1150                 1155             


Leu Cys  Val Leu His Glu Lys  Thr Pro Val Ser Asp  Arg Val Thr 
    1160                 1165                 1170             


Lys Cys  Cys Thr Glu Ser Leu  Val Asn Arg Arg Pro  Cys Phe Ser 
    1175                 1180                 1185             


Ala Leu  Glu Val Asp Glu Thr  Tyr Val Pro Lys Glu  Phe Asn Ala 
    1190                 1195                 1200             


Glu Thr  Phe Thr Phe His Ala  Asp Ile Cys Thr Leu  Ser Glu Lys 
    1205                 1210                 1215             


Glu Arg  Gln Ile Lys Lys Gln  Thr Ala Leu Val Glu  Leu Val Lys 
    1220                 1225                 1230             


His Lys  Pro Lys Ala Thr Lys  Glu Gln Leu Lys Ala  Val Met Asp 
    1235                 1240                 1245             


Asp Phe  Ala Ala Phe Val Glu  Lys Cys Cys Lys Ala  Asp Asp Lys 
    1250                 1255                 1260             


Glu Thr  Cys Phe Ala Glu Glu  Gly Lys Lys Leu Val  Ala Ala Ser 
    1265                 1270                 1275             


Gln Ala  Ala Leu Gly Leu Gly  Gly Gly Ser Ala Pro  Thr Ser Ser 
    1280                 1285                 1290             


Ser Thr  Lys Lys Thr Gln Leu  Gln Leu Glu His Leu  Leu Leu Asp 
    1295                 1300                 1305             


Leu Gln  Met Ile Leu Asn Gly  Ile Asn Asn Tyr Lys  Asn Pro Lys 
    1310                 1315                 1320             


Leu Thr  Arg Met Leu Thr Phe  Lys Phe Tyr Met Pro  Lys Lys Ala 
    1325                 1330                 1335             


Thr Glu  Leu Lys His Leu Gln  Cys Leu Glu Glu Glu  Leu Lys Pro 
    1340                 1345                 1350             


Leu Glu  Glu Val Leu Asn Leu  Ala Gln Ser Lys Asn  Phe His Leu 
    1355                 1360                 1365             


Arg Pro  Arg Asp Leu Ile Ser  Asn Ile Asn Val Ile  Val Leu Glu 
    1370                 1375                 1380             


Leu Lys  Gly Ser Glu Thr Thr  Phe Met Cys Glu Tyr  Ala Asp Glu 
    1385                 1390                 1395             


Thr Ala  Thr Ile Val Glu Phe  Leu Asn Arg Trp Ile  Thr Phe Cys 
    1400                 1405                 1410             


Gln Ser  Ile Ile Ser Thr Leu  Thr His His His His  His His His 
    1415                 1420                 1425             


His His  His 
    1430     


<210> 39
<211> 1418
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 39
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val 
            20                  25                  30          


Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr 
        35                  40                  45              


Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser 
    50                  55                  60                  


Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu 
65                  70                  75                  80  


Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu 
                85                  90                  95      


Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser 
            100                 105                 110         


Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu 
        115                 120                 125             


Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu 
    130                 135                 140                 


Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly 
145                 150                 155                 160 


Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala 
                165                 170                 175     


Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys 
            180                 185                 190         


Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu 
        195                 200                 205             


Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser 
    210                 215                 220                 


Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu 
225                 230                 235                 240 


Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu 
                245                 250                 255     


Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe 
            260                 265                 270         


Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val 
        275                 280                 285             


Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser 
    290                 295                 300                 


Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu 
305                 310                 315                 320 


Trp Ala Ser Val Pro Cys Ser Gly Gly Ser Gly Gly Gly Ser Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            340                 345                 350         


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        355                 360                 365             


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    370                 375                 380                 


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
385                 390                 395                 400 


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                405                 410                 415     


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            420                 425                 430         


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        435                 440                 445             


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    450                 455                 460                 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
465                 470                 475                 480 


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                485                 490                 495     


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            500                 505                 510         


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        515                 520                 525             


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Gly Ser Gly 
    530                 535                 540                 


Gly Gly Ser Gln Glu Gly Ala Leu Pro Arg Pro Ser Ile Ser Ala Glu 
545                 550                 555                 560 


Pro Gly Thr Val Ile Ser Pro Gly Ser His Val Thr Phe Met Cys Arg 
                565                 570                 575     


Gly Pro Val Gly Val Gln Thr Phe Arg Leu Glu Arg Glu Asp Arg Ala 
            580                 585                 590         


Lys Tyr Lys Asp Ser Tyr Asn Val Phe Arg Leu Gly Pro Ser Glu Ser 
        595                 600                 605             


Glu Ala Arg Phe His Ile Asp Ser Val Ser Glu Gly Asn Ala Gly Leu 
    610                 615                 620                 


Tyr Arg Cys Leu Tyr Tyr Lys Pro Pro Gly Trp Ser Glu His Ser Asp 
625                 630                 635                 640 


Phe Leu Glu Leu Leu Val Lys Glu Ser Ser Gly Gly Pro Asp Ser Pro 
                645                 650                 655     


Asp Thr Glu Pro Gly Ser Ser Ala Gly Thr Val Pro Gly Thr Glu Ala 
            660                 665                 670         


Ser Gly Phe Asp Ala Pro Gly Gly Gly Ser Gly Gly Gly Ser Asp Ala 
        675                 680                 685             


His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn 
    690                 695                 700                 


Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys 
705                 710                 715                 720 


Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala 
                725                 730                 735     


Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu 
            740                 745                 750         


His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu 
        755                 760                 765             


Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg 
    770                 775                 780                 


Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg 
785                 790                 795                 800 


Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn 
                805                 810                 815     


Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His 
            820                 825                 830         


Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys 
        835                 840                 845             


Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu 
    850                 855                 860                 


Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala 
865                 870                 875                 880 


Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala 
                885                 890                 895     


Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala 
            900                 905                 910         


Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His 
        915                 920                 925             


Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala 
    930                 935                 940                 


Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys 
945                 950                 955                 960 


Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile 
                965                 970                 975     


Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala 
            980                 985                 990         


Ala Asp Phe Val Glu Ser Lys Asp  Val Cys Lys Asn Tyr  Ala Glu Ala 
        995                 1000                 1005             


Lys Asp  Val Phe Leu Gly Met  Phe Leu Tyr Glu Tyr  Ala Arg Arg 
    1010                 1015                 1020             


His Pro  Asp Tyr Ser Val Val  Leu Leu Leu Arg Leu  Ala Lys Thr 
    1025                 1030                 1035             


Tyr Glu  Thr Thr Leu Glu Lys  Cys Cys Ala Ala Ala  Asp Pro His 
    1040                 1045                 1050             


Glu Cys  Tyr Ala Lys Val Phe  Asp Glu Phe Lys Pro  Leu Val Glu 
    1055                 1060                 1065             


Glu Pro  Gln Asn Leu Ile Lys  Gln Asn Cys Glu Leu  Phe Glu Gln 
    1070                 1075                 1080             


Leu Gly  Glu Tyr Lys Phe Gln  Asn Ala Leu Leu Val  Arg Tyr Thr 
    1085                 1090                 1095             


Lys Lys  Val Pro Gln Val Ser  Thr Pro Thr Leu Val  Glu Val Ser 
    1100                 1105                 1110             


Arg Asn  Leu Gly Lys Val Gly  Ser Lys Cys Cys Lys  His Pro Glu 
    1115                 1120                 1125             


Ala Lys  Arg Met Pro Cys Ala  Glu Asp Tyr Leu Ser  Val Val Leu 
    1130                 1135                 1140             


Asn Gln  Leu Cys Val Leu His  Glu Lys Thr Pro Val  Ser Asp Arg 
    1145                 1150                 1155             


Val Thr  Lys Cys Cys Thr Glu  Ser Leu Val Asn Arg  Arg Pro Cys 
    1160                 1165                 1170             


Phe Ser  Ala Leu Glu Val Asp  Glu Thr Tyr Val Pro  Lys Glu Phe 
    1175                 1180                 1185             


Asn Ala  Glu Thr Phe Thr Phe  His Ala Asp Ile Cys  Thr Leu Ser 
    1190                 1195                 1200             


Glu Lys  Glu Arg Gln Ile Lys  Lys Gln Thr Ala Leu  Val Glu Leu 
    1205                 1210                 1215             


Val Lys  His Lys Pro Lys Ala  Thr Lys Glu Gln Leu  Lys Ala Val 
    1220                 1225                 1230             


Met Asp  Asp Phe Ala Ala Phe  Val Glu Lys Cys Cys  Lys Ala Asp 
    1235                 1240                 1245             


Asp Lys  Glu Thr Cys Phe Ala  Glu Glu Gly Lys Lys  Leu Val Ala 
    1250                 1255                 1260             


Ala Ser  Gln Ala Ala Leu Gly  Leu Gly Gly Gly Ser  Ala Pro Thr 
    1265                 1270                 1275             


Ser Ser  Ser Thr Lys Lys Thr  Gln Leu Gln Leu Glu  His Leu Leu 
    1280                 1285                 1290             


Leu Asp  Leu Gln Met Ile Leu  Asn Gly Ile Asn Asn  Tyr Lys Asn 
    1295                 1300                 1305             


Pro Lys  Leu Thr Arg Met Leu  Thr Phe Lys Phe Tyr  Met Pro Lys 
    1310                 1315                 1320             


Lys Ala  Thr Glu Leu Lys His  Leu Gln Cys Leu Glu  Glu Glu Leu 
    1325                 1330                 1335             


Lys Pro  Leu Glu Glu Val Leu  Asn Leu Ala Gln Ser  Lys Asn Phe 
    1340                 1345                 1350             


His Leu  Arg Pro Arg Asp Leu  Ile Ser Asn Ile Asn  Val Ile Val 
    1355                 1360                 1365             


Leu Glu  Leu Lys Gly Ser Glu  Thr Thr Phe Met Cys  Glu Tyr Ala 
    1370                 1375                 1380             


Asp Glu  Thr Ala Thr Ile Val  Glu Phe Leu Asn Arg  Trp Ile Thr 
    1385                 1390                 1395             


Phe Cys  Gln Ser Ile Ile Ser  Thr Leu Thr His His  His His His 
    1400                 1405                 1410             


His His  His His His 
    1415             


<210> 40
<211> 1609
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 40
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val 
            20                  25                  30          


Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr 
        35                  40                  45              


Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser 
    50                  55                  60                  


Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu 
65                  70                  75                  80  


Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu 
                85                  90                  95      


Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser 
            100                 105                 110         


Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu 
        115                 120                 125             


Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu 
    130                 135                 140                 


Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly 
145                 150                 155                 160 


Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala 
                165                 170                 175     


Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys 
            180                 185                 190         


Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu 
        195                 200                 205             


Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser 
    210                 215                 220                 


Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu 
225                 230                 235                 240 


Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu 
                245                 250                 255     


Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe 
            260                 265                 270         


Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val 
        275                 280                 285             


Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser 
    290                 295                 300                 


Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu 
305                 310                 315                 320 


Trp Ala Ser Val Pro Cys Ser Gly Gly Ser Gly Gly Gly Ser Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            340                 345                 350         


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        355                 360                 365             


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    370                 375                 380                 


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
385                 390                 395                 400 


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                405                 410                 415     


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            420                 425                 430         


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        435                 440                 445             


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    450                 455                 460                 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
465                 470                 475                 480 


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                485                 490                 495     


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            500                 505                 510         


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        515                 520                 525             


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Gly Ser Gly 
    530                 535                 540                 


Gly Gly Ser Ser Gly Gln Tyr Tyr Asp Tyr Asp Phe Pro Leu Ser Ile 
545                 550                 555                 560 


Tyr Gly Gln Ser Ser Pro Asn Cys Ala Pro Glu Cys Asn Cys Pro Glu 
                565                 570                 575     


Ser Tyr Pro Ser Ala Met Tyr Cys Asp Glu Leu Lys Leu Lys Ser Val 
            580                 585                 590         


Pro Met Val Pro Pro Gly Ile Lys Tyr Leu Tyr Leu Arg Asn Asn Gln 
        595                 600                 605             


Ile Asp His Ile Asp Glu Lys Ala Phe Glu Asn Val Thr Asp Leu Gln 
    610                 615                 620                 


Trp Leu Ile Leu Asp His Asn Leu Leu Glu Asn Ser Lys Ile Lys Gly 
625                 630                 635                 640 


Arg Val Phe Ser Lys Leu Lys Gln Leu Lys Lys Leu His Ile Asn His 
                645                 650                 655     


Asn Asn Leu Thr Glu Ser Val Gly Pro Leu Pro Lys Ser Leu Glu Asp 
            660                 665                 670         


Leu Gln Leu Thr His Asn Lys Ile Thr Lys Leu Gly Ser Phe Glu Gly 
        675                 680                 685             


Leu Val Asn Leu Thr Phe Ile His Leu Gln His Asn Arg Leu Lys Glu 
    690                 695                 700                 


Asp Ala Val Ser Ala Ala Phe Lys Gly Leu Lys Ser Leu Glu Tyr Leu 
705                 710                 715                 720 


Asp Leu Ser Phe Asn Gln Ile Ala Arg Leu Pro Ser Gly Leu Pro Val 
                725                 730                 735     


Ser Leu Leu Thr Leu Tyr Leu Asp Asn Asn Lys Ile Ser Asn Ile Pro 
            740                 745                 750         


Asp Glu Tyr Phe Lys Arg Phe Asn Ala Leu Gln Tyr Leu Arg Leu Ser 
        755                 760                 765             


His Asn Glu Leu Ala Asp Ser Gly Ile Pro Gly Asn Ser Phe Asn Val 
    770                 775                 780                 


Ser Ser Leu Val Glu Leu Asp Leu Ser Tyr Asn Lys Leu Lys Asn Ile 
785                 790                 795                 800 


Pro Thr Val Asn Glu Asn Leu Glu Asn Tyr Tyr Leu Glu Val Asn Gln 
                805                 810                 815     


Leu Glu Lys Phe Asp Ile Lys Ser Phe Cys Lys Ile Leu Gly Pro Leu 
            820                 825                 830         


Ser Tyr Ser Lys Ile Lys His Leu Arg Leu Asp Gly Asn Arg Ile Ser 
        835                 840                 845             


Glu Thr Ser Leu Pro Pro Asp Met Tyr Glu Cys Leu Arg Val Ala Asn 
    850                 855                 860                 


Glu Val Thr Leu Asn Gly Gly Gly Ser Gly Gly Gly Ser Asp Ala His 
865                 870                 875                 880 


Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe 
                885                 890                 895     


Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro 
            900                 905                 910         


Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys 
        915                 920                 925             


Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His 
    930                 935                 940                 


Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr 
945                 950                 955                 960 


Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn 
                965                 970                 975     


Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu 
            980                 985                 990         


Val Arg Pro Glu Val Asp Val Met  Cys Thr Ala Phe His  Asp Asn Glu 
        995                 1000                 1005             


Glu Thr  Phe Leu Lys Lys Tyr  Leu Tyr Glu Ile Ala  Arg Arg His 
    1010                 1015                 1020             


Pro Tyr  Phe Tyr Ala Pro Glu  Leu Leu Phe Phe Ala  Lys Arg Tyr 
    1025                 1030                 1035             


Lys Ala  Ala Phe Thr Glu Cys  Cys Gln Ala Ala Asp  Lys Ala Ala 
    1040                 1045                 1050             


Cys Leu  Leu Pro Lys Leu Asp  Glu Leu Arg Asp Glu  Gly Lys Ala 
    1055                 1060                 1065             


Ser Ser  Ala Lys Gln Arg Leu  Lys Cys Ala Ser Leu  Gln Lys Phe 
    1070                 1075                 1080             


Gly Glu  Arg Ala Phe Lys Ala  Trp Ala Val Ala Arg  Leu Ser Gln 
    1085                 1090                 1095             


Arg Phe  Pro Lys Ala Glu Phe  Ala Glu Val Ser Lys  Leu Val Thr 
    1100                 1105                 1110             


Asp Leu  Thr Lys Val His Thr  Glu Cys Cys His Gly  Asp Leu Leu 
    1115                 1120                 1125             


Glu Cys  Ala Asp Asp Arg Ala  Asp Leu Ala Lys Tyr  Ile Cys Glu 
    1130                 1135                 1140             


Asn Gln  Asp Ser Ile Ser Ser  Lys Leu Lys Glu Cys  Cys Glu Lys 
    1145                 1150                 1155             


Pro Leu  Leu Glu Lys Ser His  Cys Ile Ala Glu Val  Glu Asn Asp 
    1160                 1165                 1170             


Glu Met  Pro Ala Asp Leu Pro  Ser Leu Ala Ala Asp  Phe Val Glu 
    1175                 1180                 1185             


Ser Lys  Asp Val Cys Lys Asn  Tyr Ala Glu Ala Lys  Asp Val Phe 
    1190                 1195                 1200             


Leu Gly  Met Phe Leu Tyr Glu  Tyr Ala Arg Arg His  Pro Asp Tyr 
    1205                 1210                 1215             


Ser Val  Val Leu Leu Leu Arg  Leu Ala Lys Thr Tyr  Glu Thr Thr 
    1220                 1225                 1230             


Leu Glu  Lys Cys Cys Ala Ala  Ala Asp Pro His Glu  Cys Tyr Ala 
    1235                 1240                 1245             


Lys Val  Phe Asp Glu Phe Lys  Pro Leu Val Glu Glu  Pro Gln Asn 
    1250                 1255                 1260             


Leu Ile  Lys Gln Asn Cys Glu  Leu Phe Glu Gln Leu  Gly Glu Tyr 
    1265                 1270                 1275             


Lys Phe  Gln Asn Ala Leu Leu  Val Arg Tyr Thr Lys  Lys Val Pro 
    1280                 1285                 1290             


Gln Val  Ser Thr Pro Thr Leu  Val Glu Val Ser Arg  Asn Leu Gly 
    1295                 1300                 1305             


Lys Val  Gly Ser Lys Cys Cys  Lys His Pro Glu Ala  Lys Arg Met 
    1310                 1315                 1320             


Pro Cys  Ala Glu Asp Tyr Leu  Ser Val Val Leu Asn  Gln Leu Cys 
    1325                 1330                 1335             


Val Leu  His Glu Lys Thr Pro  Val Ser Asp Arg Val  Thr Lys Cys 
    1340                 1345                 1350             


Cys Thr  Glu Ser Leu Val Asn  Arg Arg Pro Cys Phe  Ser Ala Leu 
    1355                 1360                 1365             


Glu Val  Asp Glu Thr Tyr Val  Pro Lys Glu Phe Asn  Ala Glu Thr 
    1370                 1375                 1380             


Phe Thr  Phe His Ala Asp Ile  Cys Thr Leu Ser Glu  Lys Glu Arg 
    1385                 1390                 1395             


Gln Ile  Lys Lys Gln Thr Ala  Leu Val Glu Leu Val  Lys His Lys 
    1400                 1405                 1410             


Pro Lys  Ala Thr Lys Glu Gln  Leu Lys Ala Val Met  Asp Asp Phe 
    1415                 1420                 1425             


Ala Ala  Phe Val Glu Lys Cys  Cys Lys Ala Asp Asp  Lys Glu Thr 
    1430                 1435                 1440             


Cys Phe  Ala Glu Glu Gly Lys  Lys Leu Val Ala Ala  Ser Gln Ala 
    1445                 1450                 1455             


Ala Leu  Gly Leu Gly Gly Gly  Ser Ala Pro Thr Ser  Ser Ser Thr 
    1460                 1465                 1470             


Lys Lys  Thr Gln Leu Gln Leu  Glu His Leu Leu Leu  Asp Leu Gln 
    1475                 1480                 1485             


Met Ile  Leu Asn Gly Ile Asn  Asn Tyr Lys Asn Pro  Lys Leu Thr 
    1490                 1495                 1500             


Arg Met  Leu Thr Phe Lys Phe  Tyr Met Pro Lys Lys  Ala Thr Glu 
    1505                 1510                 1515             


Leu Lys  His Leu Gln Cys Leu  Glu Glu Glu Leu Lys  Pro Leu Glu 
    1520                 1525                 1530             


Glu Val  Leu Asn Leu Ala Gln  Ser Lys Asn Phe His  Leu Arg Pro 
    1535                 1540                 1545             


Arg Asp  Leu Ile Ser Asn Ile  Asn Val Ile Val Leu  Glu Leu Lys 
    1550                 1555                 1560             


Gly Ser  Glu Thr Thr Phe Met  Cys Glu Tyr Ala Asp  Glu Thr Ala 
    1565                 1570                 1575             


Thr Ile  Val Glu Phe Leu Asn  Arg Trp Ile Thr Phe  Cys Gln Ser 
    1580                 1585                 1590             


Ile Ile  Ser Thr Leu Thr His  His His His His His  His His His 
    1595                 1600                 1605             


His 
    


<210> 41
<211> 961
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 41
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val 
            20                  25                  30          


Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr 
        35                  40                  45              


Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser 
    50                  55                  60                  


Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu 
65                  70                  75                  80  


Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu 
                85                  90                  95      


Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser 
            100                 105                 110         


Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu 
        115                 120                 125             


Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu 
    130                 135                 140                 


Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly 
145                 150                 155                 160 


Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala 
                165                 170                 175     


Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys 
            180                 185                 190         


Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu 
        195                 200                 205             


Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser 
    210                 215                 220                 


Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu 
225                 230                 235                 240 


Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu 
                245                 250                 255     


Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe 
            260                 265                 270         


Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val 
        275                 280                 285             


Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser 
    290                 295                 300                 


Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu 
305                 310                 315                 320 


Trp Ala Ser Val Pro Cys Ser Gly Gly Ser Gly Gly Gly Ser Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            340                 345                 350         


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        355                 360                 365             


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    370                 375                 380                 


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
385                 390                 395                 400 


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                405                 410                 415     


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            420                 425                 430         


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        435                 440                 445             


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    450                 455                 460                 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
465                 470                 475                 480 


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                485                 490                 495     


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            500                 505                 510         


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        515                 520                 525             


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Gly Ser Gly 
    530                 535                 540                 


Gly Gly Ser Gln Glu Glu Asp Leu Pro Arg Pro Ser Ile Ser Ala Glu 
545                 550                 555                 560 


Pro Gly Thr Val Ile Pro Leu Gly Ser His Val Thr Phe Val Cys Arg 
                565                 570                 575     


Gly Pro Val Gly Val Gln Thr Phe Arg Leu Glu Arg Glu Ser Arg Ser 
            580                 585                 590         


Thr Tyr Asn Asp Thr Glu Asp Val Ser Gln Ala Ser Pro Ser Glu Ser 
        595                 600                 605             


Glu Ala Arg Phe Arg Ile Asp Ser Val Ser Glu Gly Asn Ala Gly Pro 
    610                 615                 620                 


Tyr Arg Cys Ile Tyr Tyr Lys Pro Pro Lys Trp Ser Glu Gln Ser Asp 
625                 630                 635                 640 


Tyr Leu Glu Leu Leu Val Lys Glu Thr Ser Gly Gly Pro Asp Ser Pro 
                645                 650                 655     


Asp Thr Glu Pro Gly Ser Ser Ala Gly Pro Thr Gln Arg Pro Ser Asp 
            660                 665                 670         


Asn Ser His Asn Glu His Ala Pro Ala Ser Gln Gly Leu Lys Ala Glu 
        675                 680                 685             


His Leu Tyr Gly Gly Gly Ser Gly Gly Gly Ser Lys Val Gln Leu Val 
    690                 695                 700                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
705                 710                 715                 720 


Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Thr Trp Val 
                725                 730                 735     


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly 
            740                 745                 750         


Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Arg Gly Arg Phe Thr 
        755                 760                 765             


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
    770                 775                 780                 


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser 
785                 790                 795                 800 


Leu Ser Pro Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                805                 810                 815     


Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu 
            820                 825                 830         


Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn 
        835                 840                 845             


Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met 
    850                 855                 860                 


Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu 
865                 870                 875                 880 


Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe 
                885                 890                 895     


His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu 
            900                 905                 910         


Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu 
        915                 920                 925             


Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln 
    930                 935                 940                 


Ser Ile Ile Ser Thr Leu Thr His His His His His His His His His 
945                 950                 955                 960 


His 
    


<210> 42
<211> 948
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 42
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val 
            20                  25                  30          


Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr 
        35                  40                  45              


Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser 
    50                  55                  60                  


Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu 
65                  70                  75                  80  


Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu 
                85                  90                  95      


Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser 
            100                 105                 110         


Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu 
        115                 120                 125             


Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu 
    130                 135                 140                 


Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly 
145                 150                 155                 160 


Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala 
                165                 170                 175     


Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys 
            180                 185                 190         


Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu 
        195                 200                 205             


Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser 
    210                 215                 220                 


Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu 
225                 230                 235                 240 


Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu 
                245                 250                 255     


Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe 
            260                 265                 270         


Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val 
        275                 280                 285             


Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser 
    290                 295                 300                 


Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu 
305                 310                 315                 320 


Trp Ala Ser Val Pro Cys Ser Gly Gly Ser Gly Gly Gly Ser Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            340                 345                 350         


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        355                 360                 365             


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    370                 375                 380                 


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
385                 390                 395                 400 


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                405                 410                 415     


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            420                 425                 430         


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        435                 440                 445             


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    450                 455                 460                 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
465                 470                 475                 480 


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                485                 490                 495     


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            500                 505                 510         


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        515                 520                 525             


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Gly Ser Gly 
    530                 535                 540                 


Gly Gly Ser Gln Glu Gly Ala Leu Pro Arg Pro Ser Ile Ser Ala Glu 
545                 550                 555                 560 


Pro Gly Thr Val Ile Ser Pro Gly Ser His Val Thr Phe Met Cys Arg 
                565                 570                 575     


Gly Pro Val Gly Val Gln Thr Phe Arg Leu Glu Arg Glu Asp Arg Ala 
            580                 585                 590         


Lys Tyr Lys Asp Ser Tyr Asn Val Phe Arg Leu Gly Pro Ser Glu Ser 
        595                 600                 605             


Glu Ala Arg Phe His Ile Asp Ser Val Ser Glu Gly Asn Ala Gly Leu 
    610                 615                 620                 


Tyr Arg Cys Leu Tyr Tyr Lys Pro Pro Gly Trp Ser Glu His Ser Asp 
625                 630                 635                 640 


Phe Leu Glu Leu Leu Val Lys Glu Ser Ser Gly Gly Pro Asp Ser Pro 
                645                 650                 655     


Asp Thr Glu Pro Gly Ser Ser Ala Gly Thr Val Pro Gly Thr Glu Ala 
            660                 665                 670         


Ser Gly Phe Asp Ala Pro Gly Gly Gly Ser Gly Gly Gly Ser Lys Val 
        675                 680                 685             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    690                 695                 700                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
705                 710                 715                 720 


Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
                725                 730                 735     


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Arg Gly 
            740                 745                 750         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        755                 760                 765             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
    770                 775                 780                 


Gly Gly Ser Leu Ser Pro Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
785                 790                 795                 800 


Ser Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln 
                805                 810                 815     


Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly 
            820                 825                 830         


Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys 
        835                 840                 845             


Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu 
    850                 855                 860                 


Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser 
865                 870                 875                 880 


Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val 
                885                 890                 895     


Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr 
            900                 905                 910         


Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr 
        915                 920                 925             


Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr His His His His His His 
    930                 935                 940                 


His His His His 
945             


<210> 43
<211> 1139
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 43
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val 
            20                  25                  30          


Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr 
        35                  40                  45              


Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser 
    50                  55                  60                  


Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu 
65                  70                  75                  80  


Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu 
                85                  90                  95      


Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser 
            100                 105                 110         


Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu 
        115                 120                 125             


Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu 
    130                 135                 140                 


Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly 
145                 150                 155                 160 


Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala 
                165                 170                 175     


Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys 
            180                 185                 190         


Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu 
        195                 200                 205             


Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser 
    210                 215                 220                 


Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu 
225                 230                 235                 240 


Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu 
                245                 250                 255     


Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe 
            260                 265                 270         


Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val 
        275                 280                 285             


Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser 
    290                 295                 300                 


Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu 
305                 310                 315                 320 


Trp Ala Ser Val Pro Cys Ser Gly Gly Ser Gly Gly Gly Ser Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            340                 345                 350         


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        355                 360                 365             


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    370                 375                 380                 


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
385                 390                 395                 400 


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                405                 410                 415     


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            420                 425                 430         


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        435                 440                 445             


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    450                 455                 460                 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
465                 470                 475                 480 


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                485                 490                 495     


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            500                 505                 510         


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        515                 520                 525             


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Gly Ser Gly 
    530                 535                 540                 


Gly Gly Ser Ser Gly Gln Tyr Tyr Asp Tyr Asp Phe Pro Leu Ser Ile 
545                 550                 555                 560 


Tyr Gly Gln Ser Ser Pro Asn Cys Ala Pro Glu Cys Asn Cys Pro Glu 
                565                 570                 575     


Ser Tyr Pro Ser Ala Met Tyr Cys Asp Glu Leu Lys Leu Lys Ser Val 
            580                 585                 590         


Pro Met Val Pro Pro Gly Ile Lys Tyr Leu Tyr Leu Arg Asn Asn Gln 
        595                 600                 605             


Ile Asp His Ile Asp Glu Lys Ala Phe Glu Asn Val Thr Asp Leu Gln 
    610                 615                 620                 


Trp Leu Ile Leu Asp His Asn Leu Leu Glu Asn Ser Lys Ile Lys Gly 
625                 630                 635                 640 


Arg Val Phe Ser Lys Leu Lys Gln Leu Lys Lys Leu His Ile Asn His 
                645                 650                 655     


Asn Asn Leu Thr Glu Ser Val Gly Pro Leu Pro Lys Ser Leu Glu Asp 
            660                 665                 670         


Leu Gln Leu Thr His Asn Lys Ile Thr Lys Leu Gly Ser Phe Glu Gly 
        675                 680                 685             


Leu Val Asn Leu Thr Phe Ile His Leu Gln His Asn Arg Leu Lys Glu 
    690                 695                 700                 


Asp Ala Val Ser Ala Ala Phe Lys Gly Leu Lys Ser Leu Glu Tyr Leu 
705                 710                 715                 720 


Asp Leu Ser Phe Asn Gln Ile Ala Arg Leu Pro Ser Gly Leu Pro Val 
                725                 730                 735     


Ser Leu Leu Thr Leu Tyr Leu Asp Asn Asn Lys Ile Ser Asn Ile Pro 
            740                 745                 750         


Asp Glu Tyr Phe Lys Arg Phe Asn Ala Leu Gln Tyr Leu Arg Leu Ser 
        755                 760                 765             


His Asn Glu Leu Ala Asp Ser Gly Ile Pro Gly Asn Ser Phe Asn Val 
    770                 775                 780                 


Ser Ser Leu Val Glu Leu Asp Leu Ser Tyr Asn Lys Leu Lys Asn Ile 
785                 790                 795                 800 


Pro Thr Val Asn Glu Asn Leu Glu Asn Tyr Tyr Leu Glu Val Asn Gln 
                805                 810                 815     


Leu Glu Lys Phe Asp Ile Lys Ser Phe Cys Lys Ile Leu Gly Pro Leu 
            820                 825                 830         


Ser Tyr Ser Lys Ile Lys His Leu Arg Leu Asp Gly Asn Arg Ile Ser 
        835                 840                 845             


Glu Thr Ser Leu Pro Pro Asp Met Tyr Glu Cys Leu Arg Val Ala Asn 
    850                 855                 860                 


Glu Val Thr Leu Asn Gly Gly Gly Ser Gly Gly Gly Ser Lys Val Gln 
865                 870                 875                 880 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
                885                 890                 895     


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Thr 
            900                 905                 910         


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile 
        915                 920                 925             


Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Arg Gly Arg 
    930                 935                 940                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
945                 950                 955                 960 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly 
                965                 970                 975     


Gly Ser Leu Ser Pro Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
            980                 985                 990         


Gly Gly Gly Ser Ala Pro Thr Ser  Ser Ser Thr Lys Lys  Thr Gln Leu 
        995                 1000                 1005             


Gln Leu  Glu His Leu Leu Leu  Asp Leu Gln Met Ile  Leu Asn Gly 
    1010                 1015                 1020             


Ile Asn  Asn Tyr Lys Asn Pro  Lys Leu Thr Arg Met  Leu Thr Phe 
    1025                 1030                 1035             


Lys Phe  Tyr Met Pro Lys Lys  Ala Thr Glu Leu Lys  His Leu Gln 
    1040                 1045                 1050             


Cys Leu  Glu Glu Glu Leu Lys  Pro Leu Glu Glu Val  Leu Asn Leu 
    1055                 1060                 1065             


Ala Gln  Ser Lys Asn Phe His  Leu Arg Pro Arg Asp  Leu Ile Ser 
    1070                 1075                 1080             


Asn Ile  Asn Val Ile Val Leu  Glu Leu Lys Gly Ser  Glu Thr Thr 
    1085                 1090                 1095             


Phe Met  Cys Glu Tyr Ala Asp  Glu Thr Ala Thr Ile  Val Glu Phe 
    1100                 1105                 1110             


Leu Asn  Arg Trp Ile Thr Phe  Cys Gln Ser Ile Ile  Ser Thr Leu 
    1115                 1120                 1125             


Thr His  His His His His His  His His His His 
    1130                 1135                 


<210> 44
<211> 1438
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 44
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val 
            20                  25                  30          


Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr 
        35                  40                  45              


Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser 
    50                  55                  60                  


Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu 
65                  70                  75                  80  


Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu 
                85                  90                  95      


Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser 
            100                 105                 110         


Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu 
        115                 120                 125             


Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu 
    130                 135                 140                 


Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly 
145                 150                 155                 160 


Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala 
                165                 170                 175     


Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys 
            180                 185                 190         


Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu 
        195                 200                 205             


Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser 
    210                 215                 220                 


Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu 
225                 230                 235                 240 


Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu 
                245                 250                 255     


Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe 
            260                 265                 270         


Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val 
        275                 280                 285             


Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser 
    290                 295                 300                 


Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu 
305                 310                 315                 320 


Trp Ala Ser Val Pro Cys Ser Gly Gly Ser Gly Gly Gly Ser Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            340                 345                 350         


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        355                 360                 365             


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    370                 375                 380                 


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
385                 390                 395                 400 


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                405                 410                 415     


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            420                 425                 430         


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        435                 440                 445             


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    450                 455                 460                 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
465                 470                 475                 480 


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                485                 490                 495     


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            500                 505                 510         


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        515                 520                 525             


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser 
    530                 535                 540                 


Gly Gly Gly Ser Gln Glu Glu Asp Leu Pro Arg Pro Ser Ile Ser Ala 
545                 550                 555                 560 


Glu Pro Gly Thr Val Ile Pro Leu Gly Ser His Val Thr Phe Val Cys 
                565                 570                 575     


Arg Gly Pro Val Gly Val Gln Thr Phe Arg Leu Glu Arg Glu Ser Arg 
            580                 585                 590         


Ser Thr Tyr Asn Asp Thr Glu Asp Val Ser Gln Ala Ser Pro Ser Glu 
        595                 600                 605             


Ser Glu Ala Arg Phe Arg Ile Asp Ser Val Ser Glu Gly Asn Ala Gly 
    610                 615                 620                 


Pro Tyr Arg Cys Ile Tyr Tyr Lys Pro Pro Lys Trp Ser Glu Gln Ser 
625                 630                 635                 640 


Asp Tyr Leu Glu Leu Leu Val Lys Glu Thr Ser Gly Gly Pro Asp Ser 
                645                 650                 655     


Pro Asp Thr Glu Pro Gly Ser Ser Ala Gly Pro Thr Gln Arg Pro Ser 
            660                 665                 670         


Asp Asn Ser His Asn Glu His Ala Pro Ala Ser Gln Gly Leu Lys Ala 
        675                 680                 685             


Glu His Leu Tyr Gly Gly Gly Gly Ser Gly Gly Gly Ser Asp Ala His 
    690                 695                 700                 


Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe 
705                 710                 715                 720 


Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro 
                725                 730                 735     


Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys 
            740                 745                 750         


Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His 
        755                 760                 765             


Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr 
    770                 775                 780                 


Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn 
785                 790                 795                 800 


Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu 
                805                 810                 815     


Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu 
            820                 825                 830         


Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro 
        835                 840                 845             


Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala 
    850                 855                 860                 


Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu 
865                 870                 875                 880 


Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys 
                885                 890                 895     


Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe 
            900                 905                 910         


Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu 
        915                 920                 925             


Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr 
    930                 935                 940                 


Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp 
945                 950                 955                 960 


Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu 
                965                 970                 975     


Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala 
            980                 985                 990         


Glu Val Glu Asn Asp Glu Met Pro  Ala Asp Leu Pro Ser  Leu Ala Ala 
        995                 1000                 1005             


Asp Phe  Val Glu Ser Lys Asp  Val Cys Lys Asn Tyr  Ala Glu Ala 
    1010                 1015                 1020             


Lys Asp  Val Phe Leu Gly Met  Phe Leu Tyr Glu Tyr  Ala Arg Arg 
    1025                 1030                 1035             


His Pro  Asp Tyr Ser Val Val  Leu Leu Leu Arg Leu  Ala Lys Thr 
    1040                 1045                 1050             


Tyr Glu  Thr Thr Leu Glu Lys  Cys Cys Ala Ala Ala  Asp Pro His 
    1055                 1060                 1065             


Glu Cys  Tyr Ala Lys Val Phe  Asp Glu Phe Lys Pro  Leu Val Glu 
    1070                 1075                 1080             


Glu Pro  Gln Asn Leu Ile Lys  Gln Asn Cys Glu Leu  Phe Glu Gln 
    1085                 1090                 1095             


Leu Gly  Glu Tyr Lys Phe Gln  Asn Ala Leu Leu Val  Arg Tyr Thr 
    1100                 1105                 1110             


Lys Lys  Val Pro Gln Val Ser  Thr Pro Thr Leu Val  Glu Val Ser 
    1115                 1120                 1125             


Arg Asn  Leu Gly Lys Val Gly  Ser Lys Cys Cys Lys  His Pro Glu 
    1130                 1135                 1140             


Ala Lys  Arg Met Pro Cys Ala  Glu Asp Tyr Leu Ser  Val Val Leu 
    1145                 1150                 1155             


Asn Gln  Leu Cys Val Leu His  Glu Lys Thr Pro Val  Ser Asp Arg 
    1160                 1165                 1170             


Val Thr  Lys Cys Cys Thr Glu  Ser Leu Val Asn Arg  Arg Pro Cys 
    1175                 1180                 1185             


Phe Ser  Ala Leu Glu Val Asp  Glu Thr Tyr Val Pro  Lys Glu Phe 
    1190                 1195                 1200             


Asn Ala  Glu Thr Phe Thr Phe  His Ala Asp Ile Cys  Thr Leu Ser 
    1205                 1210                 1215             


Glu Lys  Glu Arg Gln Ile Lys  Lys Gln Thr Ala Leu  Val Glu Leu 
    1220                 1225                 1230             


Val Lys  His Lys Pro Lys Ala  Thr Lys Glu Gln Leu  Lys Ala Val 
    1235                 1240                 1245             


Met Asp  Asp Phe Ala Ala Phe  Val Glu Lys Cys Cys  Lys Ala Asp 
    1250                 1255                 1260             


Asp Lys  Glu Thr Cys Phe Ala  Glu Glu Gly Lys Lys  Leu Val Ala 
    1265                 1270                 1275             


Ala Ser  Gln Ala Ala Leu Gly  Leu Gly Gly Gly Gly  Ser Gly Gly 
    1280                 1285                 1290             


Gly Ser  Ala Pro Thr Ser Ser  Ser Thr Lys Lys Thr  Gln Leu Gln 
    1295                 1300                 1305             


Leu Glu  His Leu Leu Leu Asp  Leu Gln Met Ile Leu  Asn Gly Ile 
    1310                 1315                 1320             


Asn Asn  Tyr Lys Asn Pro Lys  Leu Thr Arg Met Leu  Thr Phe Lys 
    1325                 1330                 1335             


Phe Tyr  Met Pro Lys Lys Ala  Thr Glu Leu Lys His  Leu Gln Cys 
    1340                 1345                 1350             


Leu Glu  Glu Glu Leu Lys Pro  Leu Glu Glu Val Leu  Asn Leu Ala 
    1355                 1360                 1365             


Gln Ser  Lys Asn Phe His Leu  Arg Pro Arg Asp Leu  Ile Ser Asn 
    1370                 1375                 1380             


Ile Asn  Val Ile Val Leu Glu  Leu Lys Gly Ser Glu  Thr Thr Phe 
    1385                 1390                 1395             


Met Cys  Glu Tyr Ala Asp Glu  Thr Ala Thr Ile Val  Glu Phe Leu 
    1400                 1405                 1410             


Asn Arg  Trp Ile Thr Phe Cys  Gln Ser Ile Ile Ser  Thr Leu Thr 
    1415                 1420                 1425             


His His  His His His His His  His His His 
    1430                 1435             


<210> 45
<211> 1425
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 45
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val 
            20                  25                  30          


Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr 
        35                  40                  45              


Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser 
    50                  55                  60                  


Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu 
65                  70                  75                  80  


Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu 
                85                  90                  95      


Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser 
            100                 105                 110         


Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu 
        115                 120                 125             


Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu 
    130                 135                 140                 


Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly 
145                 150                 155                 160 


Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala 
                165                 170                 175     


Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys 
            180                 185                 190         


Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu 
        195                 200                 205             


Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser 
    210                 215                 220                 


Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu 
225                 230                 235                 240 


Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu 
                245                 250                 255     


Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe 
            260                 265                 270         


Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val 
        275                 280                 285             


Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser 
    290                 295                 300                 


Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu 
305                 310                 315                 320 


Trp Ala Ser Val Pro Cys Ser Gly Gly Ser Gly Gly Gly Ser Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            340                 345                 350         


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        355                 360                 365             


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    370                 375                 380                 


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
385                 390                 395                 400 


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                405                 410                 415     


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            420                 425                 430         


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        435                 440                 445             


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    450                 455                 460                 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
465                 470                 475                 480 


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                485                 490                 495     


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            500                 505                 510         


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        515                 520                 525             


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser 
    530                 535                 540                 


Gly Gly Gly Ser Gln Glu Gly Ala Leu Pro Arg Pro Ser Ile Ser Ala 
545                 550                 555                 560 


Glu Pro Gly Thr Val Ile Ser Pro Gly Ser His Val Thr Phe Met Cys 
                565                 570                 575     


Arg Gly Pro Val Gly Val Gln Thr Phe Arg Leu Glu Arg Glu Asp Arg 
            580                 585                 590         


Ala Lys Tyr Lys Asp Ser Tyr Asn Val Phe Arg Leu Gly Pro Ser Glu 
        595                 600                 605             


Ser Glu Ala Arg Phe His Ile Asp Ser Val Ser Glu Gly Asn Ala Gly 
    610                 615                 620                 


Leu Tyr Arg Cys Leu Tyr Tyr Lys Pro Pro Gly Trp Ser Glu His Ser 
625                 630                 635                 640 


Asp Phe Leu Glu Leu Leu Val Lys Glu Ser Ser Gly Gly Pro Asp Ser 
                645                 650                 655     


Pro Asp Thr Glu Pro Gly Ser Ser Ala Gly Thr Val Pro Gly Thr Glu 
            660                 665                 670         


Ala Ser Gly Phe Asp Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Ser 
        675                 680                 685             


Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
    690                 695                 700                 


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
705                 710                 715                 720 


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
                725                 730                 735     


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
            740                 745                 750         


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
        755                 760                 765             


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
    770                 775                 780                 


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
785                 790                 795                 800 


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
                805                 810                 815     


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
            820                 825                 830         


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
        835                 840                 845             


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
    850                 855                 860                 


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
865                 870                 875                 880 


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
                885                 890                 895     


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
            900                 905                 910         


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
        915                 920                 925             


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
    930                 935                 940                 


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
945                 950                 955                 960 


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
                965                 970                 975     


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
            980                 985                 990         


Leu Ala Ala Asp Phe Val Glu Ser  Lys Asp Val Cys Lys  Asn Tyr Ala 
        995                 1000                 1005             


Glu Ala  Lys Asp Val Phe Leu  Gly Met Phe Leu Tyr  Glu Tyr Ala 
    1010                 1015                 1020             


Arg Arg  His Pro Asp Tyr Ser  Val Val Leu Leu Leu  Arg Leu Ala 
    1025                 1030                 1035             


Lys Thr  Tyr Glu Thr Thr Leu  Glu Lys Cys Cys Ala  Ala Ala Asp 
    1040                 1045                 1050             


Pro His  Glu Cys Tyr Ala Lys  Val Phe Asp Glu Phe  Lys Pro Leu 
    1055                 1060                 1065             


Val Glu  Glu Pro Gln Asn Leu  Ile Lys Gln Asn Cys  Glu Leu Phe 
    1070                 1075                 1080             


Glu Gln  Leu Gly Glu Tyr Lys  Phe Gln Asn Ala Leu  Leu Val Arg 
    1085                 1090                 1095             


Tyr Thr  Lys Lys Val Pro Gln  Val Ser Thr Pro Thr  Leu Val Glu 
    1100                 1105                 1110             


Val Ser  Arg Asn Leu Gly Lys  Val Gly Ser Lys Cys  Cys Lys His 
    1115                 1120                 1125             


Pro Glu  Ala Lys Arg Met Pro  Cys Ala Glu Asp Tyr  Leu Ser Val 
    1130                 1135                 1140             


Val Leu  Asn Gln Leu Cys Val  Leu His Glu Lys Thr  Pro Val Ser 
    1145                 1150                 1155             


Asp Arg  Val Thr Lys Cys Cys  Thr Glu Ser Leu Val  Asn Arg Arg 
    1160                 1165                 1170             


Pro Cys  Phe Ser Ala Leu Glu  Val Asp Glu Thr Tyr  Val Pro Lys 
    1175                 1180                 1185             


Glu Phe  Asn Ala Glu Thr Phe  Thr Phe His Ala Asp  Ile Cys Thr 
    1190                 1195                 1200             


Leu Ser  Glu Lys Glu Arg Gln  Ile Lys Lys Gln Thr  Ala Leu Val 
    1205                 1210                 1215             


Glu Leu  Val Lys His Lys Pro  Lys Ala Thr Lys Glu  Gln Leu Lys 
    1220                 1225                 1230             


Ala Val  Met Asp Asp Phe Ala  Ala Phe Val Glu Lys  Cys Cys Lys 
    1235                 1240                 1245             


Ala Asp  Asp Lys Glu Thr Cys  Phe Ala Glu Glu Gly  Lys Lys Leu 
    1250                 1255                 1260             


Val Ala  Ala Ser Gln Ala Ala  Leu Gly Leu Gly Gly  Gly Gly Ser 
    1265                 1270                 1275             


Gly Gly  Gly Ser Ala Pro Thr  Ser Ser Ser Thr Lys  Lys Thr Gln 
    1280                 1285                 1290             


Leu Gln  Leu Glu His Leu Leu  Leu Asp Leu Gln Met  Ile Leu Asn 
    1295                 1300                 1305             


Gly Ile  Asn Asn Tyr Lys Asn  Pro Lys Leu Thr Arg  Met Leu Thr 
    1310                 1315                 1320             


Phe Lys  Phe Tyr Met Pro Lys  Lys Ala Thr Glu Leu  Lys His Leu 
    1325                 1330                 1335             


Gln Cys  Leu Glu Glu Glu Leu  Lys Pro Leu Glu Glu  Val Leu Asn 
    1340                 1345                 1350             


Leu Ala  Gln Ser Lys Asn Phe  His Leu Arg Pro Arg  Asp Leu Ile 
    1355                 1360                 1365             


Ser Asn  Ile Asn Val Ile Val  Leu Glu Leu Lys Gly  Ser Glu Thr 
    1370                 1375                 1380             


Thr Phe  Met Cys Glu Tyr Ala  Asp Glu Thr Ala Thr  Ile Val Glu 
    1385                 1390                 1395             


Phe Leu  Asn Arg Trp Ile Thr  Phe Cys Gln Ser Ile  Ile Ser Thr 
    1400                 1405                 1410             


Leu Thr  His His His His His  His His His His His  
    1415                 1420                 1425 


<210> 46
<211> 1616
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 46
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val 
            20                  25                  30          


Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr 
        35                  40                  45              


Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser 
    50                  55                  60                  


Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu 
65                  70                  75                  80  


Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu 
                85                  90                  95      


Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser 
            100                 105                 110         


Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu 
        115                 120                 125             


Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu 
    130                 135                 140                 


Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly 
145                 150                 155                 160 


Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala 
                165                 170                 175     


Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys 
            180                 185                 190         


Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu 
        195                 200                 205             


Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser 
    210                 215                 220                 


Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu 
225                 230                 235                 240 


Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu 
                245                 250                 255     


Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe 
            260                 265                 270         


Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val 
        275                 280                 285             


Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser 
    290                 295                 300                 


Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu 
305                 310                 315                 320 


Trp Ala Ser Val Pro Cys Ser Gly Gly Ser Gly Gly Gly Ser Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            340                 345                 350         


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        355                 360                 365             


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    370                 375                 380                 


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
385                 390                 395                 400 


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                405                 410                 415     


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            420                 425                 430         


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        435                 440                 445             


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    450                 455                 460                 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
465                 470                 475                 480 


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                485                 490                 495     


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            500                 505                 510         


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        515                 520                 525             


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser 
    530                 535                 540                 


Gly Gly Gly Ser Ser Gly Gln Tyr Tyr Asp Tyr Asp Phe Pro Leu Ser 
545                 550                 555                 560 


Ile Tyr Gly Gln Ser Ser Pro Asn Cys Ala Pro Glu Cys Asn Cys Pro 
                565                 570                 575     


Glu Ser Tyr Pro Ser Ala Met Tyr Cys Asp Glu Leu Lys Leu Lys Ser 
            580                 585                 590         


Val Pro Met Val Pro Pro Gly Ile Lys Tyr Leu Tyr Leu Arg Asn Asn 
        595                 600                 605             


Gln Ile Asp His Ile Asp Glu Lys Ala Phe Glu Asn Val Thr Asp Leu 
    610                 615                 620                 


Gln Trp Leu Ile Leu Asp His Asn Leu Leu Glu Asn Ser Lys Ile Lys 
625                 630                 635                 640 


Gly Arg Val Phe Ser Lys Leu Lys Gln Leu Lys Lys Leu His Ile Asn 
                645                 650                 655     


His Asn Asn Leu Thr Glu Ser Val Gly Pro Leu Pro Lys Ser Leu Glu 
            660                 665                 670         


Asp Leu Gln Leu Thr His Asn Lys Ile Thr Lys Leu Gly Ser Phe Glu 
        675                 680                 685             


Gly Leu Val Asn Leu Thr Phe Ile His Leu Gln His Asn Arg Leu Lys 
    690                 695                 700                 


Glu Asp Ala Val Ser Ala Ala Phe Lys Gly Leu Lys Ser Leu Glu Tyr 
705                 710                 715                 720 


Leu Asp Leu Ser Phe Asn Gln Ile Ala Arg Leu Pro Ser Gly Leu Pro 
                725                 730                 735     


Val Ser Leu Leu Thr Leu Tyr Leu Asp Asn Asn Lys Ile Ser Asn Ile 
            740                 745                 750         


Pro Asp Glu Tyr Phe Lys Arg Phe Asn Ala Leu Gln Tyr Leu Arg Leu 
        755                 760                 765             


Ser His Asn Glu Leu Ala Asp Ser Gly Ile Pro Gly Asn Ser Phe Asn 
    770                 775                 780                 


Val Ser Ser Leu Val Glu Leu Asp Leu Ser Tyr Asn Lys Leu Lys Asn 
785                 790                 795                 800 


Ile Pro Thr Val Asn Glu Asn Leu Glu Asn Tyr Tyr Leu Glu Val Asn 
                805                 810                 815     


Gln Leu Glu Lys Phe Asp Ile Lys Ser Phe Cys Lys Ile Leu Gly Pro 
            820                 825                 830         


Leu Ser Tyr Ser Lys Ile Lys His Leu Arg Leu Asp Gly Asn Arg Ile 
        835                 840                 845             


Ser Glu Thr Ser Leu Pro Pro Asp Met Tyr Glu Cys Leu Arg Val Ala 
    850                 855                 860                 


Asn Glu Val Thr Leu Asn Gly Gly Gly Gly Ser Gly Gly Gly Ser Asp 
865                 870                 875                 880 


Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu 
                885                 890                 895     


Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln 
            900                 905                 910         


Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe 
        915                 920                 925             


Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser 
    930                 935                 940                 


Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg 
945                 950                 955                 960 


Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu 
                965                 970                 975     


Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro 
            980                 985                 990         


Arg Leu Val Arg Pro Glu Val Asp  Val Met Cys Thr Ala  Phe His Asp 
        995                 1000                 1005             


Asn Glu  Glu Thr Phe Leu Lys  Lys Tyr Leu Tyr Glu  Ile Ala Arg 
    1010                 1015                 1020             


Arg His  Pro Tyr Phe Tyr Ala  Pro Glu Leu Leu Phe  Phe Ala Lys 
    1025                 1030                 1035             


Arg Tyr  Lys Ala Ala Phe Thr  Glu Cys Cys Gln Ala  Ala Asp Lys 
    1040                 1045                 1050             


Ala Ala  Cys Leu Leu Pro Lys  Leu Asp Glu Leu Arg  Asp Glu Gly 
    1055                 1060                 1065             


Lys Ala  Ser Ser Ala Lys Gln  Arg Leu Lys Cys Ala  Ser Leu Gln 
    1070                 1075                 1080             


Lys Phe  Gly Glu Arg Ala Phe  Lys Ala Trp Ala Val  Ala Arg Leu 
    1085                 1090                 1095             


Ser Gln  Arg Phe Pro Lys Ala  Glu Phe Ala Glu Val  Ser Lys Leu 
    1100                 1105                 1110             


Val Thr  Asp Leu Thr Lys Val  His Thr Glu Cys Cys  His Gly Asp 
    1115                 1120                 1125             


Leu Leu  Glu Cys Ala Asp Asp  Arg Ala Asp Leu Ala  Lys Tyr Ile 
    1130                 1135                 1140             


Cys Glu  Asn Gln Asp Ser Ile  Ser Ser Lys Leu Lys  Glu Cys Cys 
    1145                 1150                 1155             


Glu Lys  Pro Leu Leu Glu Lys  Ser His Cys Ile Ala  Glu Val Glu 
    1160                 1165                 1170             


Asn Asp  Glu Met Pro Ala Asp  Leu Pro Ser Leu Ala  Ala Asp Phe 
    1175                 1180                 1185             


Val Glu  Ser Lys Asp Val Cys  Lys Asn Tyr Ala Glu  Ala Lys Asp 
    1190                 1195                 1200             


Val Phe  Leu Gly Met Phe Leu  Tyr Glu Tyr Ala Arg  Arg His Pro 
    1205                 1210                 1215             


Asp Tyr  Ser Val Val Leu Leu  Leu Arg Leu Ala Lys  Thr Tyr Glu 
    1220                 1225                 1230             


Thr Thr  Leu Glu Lys Cys Cys  Ala Ala Ala Asp Pro  His Glu Cys 
    1235                 1240                 1245             


Tyr Ala  Lys Val Phe Asp Glu  Phe Lys Pro Leu Val  Glu Glu Pro 
    1250                 1255                 1260             


Gln Asn  Leu Ile Lys Gln Asn  Cys Glu Leu Phe Glu  Gln Leu Gly 
    1265                 1270                 1275             


Glu Tyr  Lys Phe Gln Asn Ala  Leu Leu Val Arg Tyr  Thr Lys Lys 
    1280                 1285                 1290             


Val Pro  Gln Val Ser Thr Pro  Thr Leu Val Glu Val  Ser Arg Asn 
    1295                 1300                 1305             


Leu Gly  Lys Val Gly Ser Lys  Cys Cys Lys His Pro  Glu Ala Lys 
    1310                 1315                 1320             


Arg Met  Pro Cys Ala Glu Asp  Tyr Leu Ser Val Val  Leu Asn Gln 
    1325                 1330                 1335             


Leu Cys  Val Leu His Glu Lys  Thr Pro Val Ser Asp  Arg Val Thr 
    1340                 1345                 1350             


Lys Cys  Cys Thr Glu Ser Leu  Val Asn Arg Arg Pro  Cys Phe Ser 
    1355                 1360                 1365             


Ala Leu  Glu Val Asp Glu Thr  Tyr Val Pro Lys Glu  Phe Asn Ala 
    1370                 1375                 1380             


Glu Thr  Phe Thr Phe His Ala  Asp Ile Cys Thr Leu  Ser Glu Lys 
    1385                 1390                 1395             


Glu Arg  Gln Ile Lys Lys Gln  Thr Ala Leu Val Glu  Leu Val Lys 
    1400                 1405                 1410             


His Lys  Pro Lys Ala Thr Lys  Glu Gln Leu Lys Ala  Val Met Asp 
    1415                 1420                 1425             


Asp Phe  Ala Ala Phe Val Glu  Lys Cys Cys Lys Ala  Asp Asp Lys 
    1430                 1435                 1440             


Glu Thr  Cys Phe Ala Glu Glu  Gly Lys Lys Leu Val  Ala Ala Ser 
    1445                 1450                 1455             


Gln Ala  Ala Leu Gly Leu Gly  Gly Gly Gly Ser Gly  Gly Gly Ser 
    1460                 1465                 1470             


Ala Pro  Thr Ser Ser Ser Thr  Lys Lys Thr Gln Leu  Gln Leu Glu 
    1475                 1480                 1485             


His Leu  Leu Leu Asp Leu Gln  Met Ile Leu Asn Gly  Ile Asn Asn 
    1490                 1495                 1500             


Tyr Lys  Asn Pro Lys Leu Thr  Arg Met Leu Thr Phe  Lys Phe Tyr 
    1505                 1510                 1515             


Met Pro  Lys Lys Ala Thr Glu  Leu Lys His Leu Gln  Cys Leu Glu 
    1520                 1525                 1530             


Glu Glu  Leu Lys Pro Leu Glu  Glu Val Leu Asn Leu  Ala Gln Ser 
    1535                 1540                 1545             


Lys Asn  Phe His Leu Arg Pro  Arg Asp Leu Ile Ser  Asn Ile Asn 
    1550                 1555                 1560             


Val Ile  Val Leu Glu Leu Lys  Gly Ser Glu Thr Thr  Phe Met Cys 
    1565                 1570                 1575             


Glu Tyr  Ala Asp Glu Thr Ala  Thr Ile Val Glu Phe  Leu Asn Arg 
    1580                 1585                 1590             


Trp Ile  Thr Phe Cys Gln Ser  Ile Ile Ser Thr Leu  Thr His His 
    1595                 1600                 1605             


His His  His His His His His  His 
    1610                 1615     


<210> 47
<211> 968
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 47
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val 
            20                  25                  30          


Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr 
        35                  40                  45              


Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser 
    50                  55                  60                  


Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu 
65                  70                  75                  80  


Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu 
                85                  90                  95      


Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser 
            100                 105                 110         


Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu 
        115                 120                 125             


Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu 
    130                 135                 140                 


Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly 
145                 150                 155                 160 


Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala 
                165                 170                 175     


Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys 
            180                 185                 190         


Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu 
        195                 200                 205             


Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser 
    210                 215                 220                 


Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu 
225                 230                 235                 240 


Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu 
                245                 250                 255     


Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe 
            260                 265                 270         


Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val 
        275                 280                 285             


Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser 
    290                 295                 300                 


Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu 
305                 310                 315                 320 


Trp Ala Ser Val Pro Cys Ser Gly Gly Ser Gly Gly Gly Ser Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            340                 345                 350         


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        355                 360                 365             


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    370                 375                 380                 


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
385                 390                 395                 400 


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                405                 410                 415     


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            420                 425                 430         


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        435                 440                 445             


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    450                 455                 460                 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
465                 470                 475                 480 


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                485                 490                 495     


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            500                 505                 510         


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        515                 520                 525             


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser 
    530                 535                 540                 


Gly Gly Gly Ser Gln Glu Glu Asp Leu Pro Arg Pro Ser Ile Ser Ala 
545                 550                 555                 560 


Glu Pro Gly Thr Val Ile Pro Leu Gly Ser His Val Thr Phe Val Cys 
                565                 570                 575     


Arg Gly Pro Val Gly Val Gln Thr Phe Arg Leu Glu Arg Glu Ser Arg 
            580                 585                 590         


Ser Thr Tyr Asn Asp Thr Glu Asp Val Ser Gln Ala Ser Pro Ser Glu 
        595                 600                 605             


Ser Glu Ala Arg Phe Arg Ile Asp Ser Val Ser Glu Gly Asn Ala Gly 
    610                 615                 620                 


Pro Tyr Arg Cys Ile Tyr Tyr Lys Pro Pro Lys Trp Ser Glu Gln Ser 
625                 630                 635                 640 


Asp Tyr Leu Glu Leu Leu Val Lys Glu Thr Ser Gly Gly Pro Asp Ser 
                645                 650                 655     


Pro Asp Thr Glu Pro Gly Ser Ser Ala Gly Pro Thr Gln Arg Pro Ser 
            660                 665                 670         


Asp Asn Ser His Asn Glu His Ala Pro Ala Ser Gln Gly Leu Lys Ala 
        675                 680                 685             


Glu His Leu Tyr Gly Gly Gly Gly Ser Gly Gly Gly Ser Lys Val Gln 
    690                 695                 700                 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
705                 710                 715                 720 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Thr 
                725                 730                 735     


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile 
            740                 745                 750         


Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Arg Gly Arg 
        755                 760                 765             


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
    770                 775                 780                 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly 
785                 790                 795                 800 


Gly Ser Leu Ser Pro Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
                805                 810                 815     


Gly Gly Gly Gly Ser Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr 
            820                 825                 830         


Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met 
        835                 840                 845             


Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met 
    850                 855                 860                 


Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His 
865                 870                 875                 880 


Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn 
                885                 890                 895     


Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser 
            900                 905                 910         


Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe 
        915                 920                 925             


Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn 
    930                 935                 940                 


Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr His His 
945                 950                 955                 960 


His His His His His His His His 
                965             


<210> 48
<211> 955
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 48
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val 
            20                  25                  30          


Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr 
        35                  40                  45              


Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser 
    50                  55                  60                  


Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu 
65                  70                  75                  80  


Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu 
                85                  90                  95      


Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser 
            100                 105                 110         


Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu 
        115                 120                 125             


Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu 
    130                 135                 140                 


Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly 
145                 150                 155                 160 


Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala 
                165                 170                 175     


Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys 
            180                 185                 190         


Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu 
        195                 200                 205             


Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser 
    210                 215                 220                 


Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu 
225                 230                 235                 240 


Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu 
                245                 250                 255     


Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe 
            260                 265                 270         


Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val 
        275                 280                 285             


Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser 
    290                 295                 300                 


Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu 
305                 310                 315                 320 


Trp Ala Ser Val Pro Cys Ser Gly Gly Ser Gly Gly Gly Ser Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            340                 345                 350         


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        355                 360                 365             


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    370                 375                 380                 


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
385                 390                 395                 400 


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                405                 410                 415     


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            420                 425                 430         


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        435                 440                 445             


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    450                 455                 460                 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
465                 470                 475                 480 


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                485                 490                 495     


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            500                 505                 510         


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        515                 520                 525             


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser 
    530                 535                 540                 


Gly Gly Gly Ser Gln Glu Gly Ala Leu Pro Arg Pro Ser Ile Ser Ala 
545                 550                 555                 560 


Glu Pro Gly Thr Val Ile Ser Pro Gly Ser His Val Thr Phe Met Cys 
                565                 570                 575     


Arg Gly Pro Val Gly Val Gln Thr Phe Arg Leu Glu Arg Glu Asp Arg 
            580                 585                 590         


Ala Lys Tyr Lys Asp Ser Tyr Asn Val Phe Arg Leu Gly Pro Ser Glu 
        595                 600                 605             


Ser Glu Ala Arg Phe His Ile Asp Ser Val Ser Glu Gly Asn Ala Gly 
    610                 615                 620                 


Leu Tyr Arg Cys Leu Tyr Tyr Lys Pro Pro Gly Trp Ser Glu His Ser 
625                 630                 635                 640 


Asp Phe Leu Glu Leu Leu Val Lys Glu Ser Ser Gly Gly Pro Asp Ser 
                645                 650                 655     


Pro Asp Thr Glu Pro Gly Ser Ser Ala Gly Thr Val Pro Gly Thr Glu 
            660                 665                 670         


Ala Ser Gly Phe Asp Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Ser 
        675                 680                 685             


Lys Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
    690                 695                 700                 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
705                 710                 715                 720 


Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                725                 730                 735     


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
            740                 745                 750         


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
        755                 760                 765             


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
    770                 775                 780                 


Thr Ile Gly Gly Ser Leu Ser Pro Ser Ser Gln Gly Thr Leu Val Thr 
785                 790                 795                 800 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Ala Pro Thr Ser 
                805                 810                 815     


Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp 
            820                 825                 830         


Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu 
        835                 840                 845             


Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu 
    850                 855                 860                 


Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu 
865                 870                 875                 880 


Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp 
                885                 890                 895     


Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu 
            900                 905                 910         


Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu 
        915                 920                 925             


Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu 
    930                 935                 940                 


Thr His His His His His His His His His His 
945                 950                 955 


<210> 49
<211> 1146
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 49
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val 
            20                  25                  30          


Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr 
        35                  40                  45              


Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser 
    50                  55                  60                  


Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu 
65                  70                  75                  80  


Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu 
                85                  90                  95      


Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser 
            100                 105                 110         


Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu 
        115                 120                 125             


Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu 
    130                 135                 140                 


Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly 
145                 150                 155                 160 


Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala 
                165                 170                 175     


Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys 
            180                 185                 190         


Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu 
        195                 200                 205             


Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser 
    210                 215                 220                 


Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu 
225                 230                 235                 240 


Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu 
                245                 250                 255     


Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe 
            260                 265                 270         


Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val 
        275                 280                 285             


Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser 
    290                 295                 300                 


Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu 
305                 310                 315                 320 


Trp Ala Ser Val Pro Cys Ser Gly Gly Ser Gly Gly Gly Ser Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            340                 345                 350         


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        355                 360                 365             


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    370                 375                 380                 


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
385                 390                 395                 400 


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                405                 410                 415     


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            420                 425                 430         


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        435                 440                 445             


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    450                 455                 460                 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
465                 470                 475                 480 


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                485                 490                 495     


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            500                 505                 510         


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        515                 520                 525             


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser 
    530                 535                 540                 


Gly Gly Gly Ser Ser Gly Gln Tyr Tyr Asp Tyr Asp Phe Pro Leu Ser 
545                 550                 555                 560 


Ile Tyr Gly Gln Ser Ser Pro Asn Cys Ala Pro Glu Cys Asn Cys Pro 
                565                 570                 575     


Glu Ser Tyr Pro Ser Ala Met Tyr Cys Asp Glu Leu Lys Leu Lys Ser 
            580                 585                 590         


Val Pro Met Val Pro Pro Gly Ile Lys Tyr Leu Tyr Leu Arg Asn Asn 
        595                 600                 605             


Gln Ile Asp His Ile Asp Glu Lys Ala Phe Glu Asn Val Thr Asp Leu 
    610                 615                 620                 


Gln Trp Leu Ile Leu Asp His Asn Leu Leu Glu Asn Ser Lys Ile Lys 
625                 630                 635                 640 


Gly Arg Val Phe Ser Lys Leu Lys Gln Leu Lys Lys Leu His Ile Asn 
                645                 650                 655     


His Asn Asn Leu Thr Glu Ser Val Gly Pro Leu Pro Lys Ser Leu Glu 
            660                 665                 670         


Asp Leu Gln Leu Thr His Asn Lys Ile Thr Lys Leu Gly Ser Phe Glu 
        675                 680                 685             


Gly Leu Val Asn Leu Thr Phe Ile His Leu Gln His Asn Arg Leu Lys 
    690                 695                 700                 


Glu Asp Ala Val Ser Ala Ala Phe Lys Gly Leu Lys Ser Leu Glu Tyr 
705                 710                 715                 720 


Leu Asp Leu Ser Phe Asn Gln Ile Ala Arg Leu Pro Ser Gly Leu Pro 
                725                 730                 735     


Val Ser Leu Leu Thr Leu Tyr Leu Asp Asn Asn Lys Ile Ser Asn Ile 
            740                 745                 750         


Pro Asp Glu Tyr Phe Lys Arg Phe Asn Ala Leu Gln Tyr Leu Arg Leu 
        755                 760                 765             


Ser His Asn Glu Leu Ala Asp Ser Gly Ile Pro Gly Asn Ser Phe Asn 
    770                 775                 780                 


Val Ser Ser Leu Val Glu Leu Asp Leu Ser Tyr Asn Lys Leu Lys Asn 
785                 790                 795                 800 


Ile Pro Thr Val Asn Glu Asn Leu Glu Asn Tyr Tyr Leu Glu Val Asn 
                805                 810                 815     


Gln Leu Glu Lys Phe Asp Ile Lys Ser Phe Cys Lys Ile Leu Gly Pro 
            820                 825                 830         


Leu Ser Tyr Ser Lys Ile Lys His Leu Arg Leu Asp Gly Asn Arg Ile 
        835                 840                 845             


Ser Glu Thr Ser Leu Pro Pro Asp Met Tyr Glu Cys Leu Arg Val Ala 
    850                 855                 860                 


Asn Glu Val Thr Leu Asn Gly Gly Gly Gly Ser Gly Gly Gly Ser Lys 
865                 870                 875                 880 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                885                 890                 895     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
            900                 905                 910         


Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
        915                 920                 925             


Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Arg 
    930                 935                 940                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
945                 950                 955                 960 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                965                 970                 975     


Ile Gly Gly Ser Leu Ser Pro Ser Ser Gln Gly Thr Leu Val Thr Val 
            980                 985                 990         


Ser Ser Gly Gly Gly Gly Ser Gly  Gly Gly Ser Ala Pro  Thr Ser Ser 
        995                 1000                 1005             


Ser Thr  Lys Lys Thr Gln Leu  Gln Leu Glu His Leu  Leu Leu Asp 
    1010                 1015                 1020             


Leu Gln  Met Ile Leu Asn Gly  Ile Asn Asn Tyr Lys  Asn Pro Lys 
    1025                 1030                 1035             


Leu Thr  Arg Met Leu Thr Phe  Lys Phe Tyr Met Pro  Lys Lys Ala 
    1040                 1045                 1050             


Thr Glu  Leu Lys His Leu Gln  Cys Leu Glu Glu Glu  Leu Lys Pro 
    1055                 1060                 1065             


Leu Glu  Glu Val Leu Asn Leu  Ala Gln Ser Lys Asn  Phe His Leu 
    1070                 1075                 1080             


Arg Pro  Arg Asp Leu Ile Ser  Asn Ile Asn Val Ile  Val Leu Glu 
    1085                 1090                 1095             


Leu Lys  Gly Ser Glu Thr Thr  Phe Met Cys Glu Tyr  Ala Asp Glu 
    1100                 1105                 1110             


Thr Ala  Thr Ile Val Glu Phe  Leu Asn Arg Trp Ile  Thr Phe Cys 
    1115                 1120                 1125             


Gln Ser  Ile Ile Ser Thr Leu  Thr His His His His  His His His 
    1130                 1135                 1140             


His His  His 
    1145     


<210> 50
<211> 1438
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 50
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln 
            20                  25                  30          


Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly 
        35                  40                  45              


Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys 
    50                  55                  60                  


Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu 
65                  70                  75                  80  


Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser 
                85                  90                  95      


Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val 
            100                 105                 110         


Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr 
        115                 120                 125             


Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr 
    130                 135                 140                 


Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Ser Gln Glu Glu Asp Leu Pro Arg Pro Ser Ile Ser Ala Glu 
                165                 170                 175     


Pro Gly Thr Val Ile Pro Leu Gly Ser His Val Thr Phe Val Cys Arg 
            180                 185                 190         


Gly Pro Val Gly Val Gln Thr Phe Arg Leu Glu Arg Glu Ser Arg Ser 
        195                 200                 205             


Thr Tyr Asn Asp Thr Glu Asp Val Ser Gln Ala Ser Pro Ser Glu Ser 
    210                 215                 220                 


Glu Ala Arg Phe Arg Ile Asp Ser Val Ser Glu Gly Asn Ala Gly Pro 
225                 230                 235                 240 


Tyr Arg Cys Ile Tyr Tyr Lys Pro Pro Lys Trp Ser Glu Gln Ser Asp 
                245                 250                 255     


Tyr Leu Glu Leu Leu Val Lys Glu Thr Ser Gly Gly Pro Asp Ser Pro 
            260                 265                 270         


Asp Thr Glu Pro Gly Ser Ser Ala Gly Pro Thr Gln Arg Pro Ser Asp 
        275                 280                 285             


Asn Ser His Asn Glu His Ala Pro Ala Ser Gln Gly Leu Lys Ala Glu 
    290                 295                 300                 


His Leu Tyr Gly Gly Gly Gly Ser Gly Gly Gly Ser Asp Ala His Lys 
305                 310                 315                 320 


Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys 
                325                 330                 335     


Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe 
            340                 345                 350         


Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr 
        355                 360                 365             


Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr 
    370                 375                 380                 


Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr 
385                 390                 395                 400 


Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu 
                405                 410                 415     


Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val 
            420                 425                 430         


Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu 
        435                 440                 445             


Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr 
    450                 455                 460                 


Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala 
465                 470                 475                 480 


Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro 
                485                 490                 495     


Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln 
            500                 505                 510         


Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys 
        515                 520                 525             


Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe 
    530                 535                 540                 


Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu 
545                 550                 555                 560 


Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu 
                565                 570                 575     


Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys 
            580                 585                 590         


Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu 
        595                 600                 605             


Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp 
    610                 615                 620                 


Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp 
625                 630                 635                 640 


Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp 
                645                 650                 655     


Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr 
            660                 665                 670         


Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys 
        675                 680                 685             


Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile 
    690                 695                 700                 


Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln 
705                 710                 715                 720 


Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr 
                725                 730                 735     


Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys 
            740                 745                 750         


Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr 
        755                 760                 765             


Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro 
    770                 775                 780                 


Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg 
785                 790                 795                 800 


Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys 
                805                 810                 815     


Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu 
            820                 825                 830         


Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu 
        835                 840                 845             


Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met 
    850                 855                 860                 


Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys 
865                 870                 875                 880 


Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln 
                885                 890                 895     


Ala Ala Leu Gly Leu Gly Gly Gly Gly Ser Gly Gly Gly Ser Ile Trp 
            900                 905                 910         


Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr Pro Asp 
        915                 920                 925             


Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu Glu Asp 
    930                 935                 940                 


Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly Ser Gly 
945                 950                 955                 960 


Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly Gln Tyr 
                965                 970                 975     


Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu Leu Leu 
            980                 985                 990         


His Lys Lys Glu Asp Gly Ile Trp  Ser Thr Asp Ile Leu  Lys Asp Gln 
        995                 1000                 1005             


Lys Glu  Pro Lys Asn Lys Thr  Phe Leu Arg Cys Glu  Ala Lys Asn 
    1010                 1015                 1020             


Tyr Ser  Gly Arg Phe Thr Cys  Trp Trp Leu Thr Thr  Ile Ser Thr 
    1025                 1030                 1035             


Asp Leu  Thr Phe Ser Val Lys  Ser Ser Arg Gly Ser  Ser Asp Pro 
    1040                 1045                 1050             


Gln Gly  Val Thr Cys Gly Ala  Ala Thr Leu Ser Ala  Glu Arg Val 
    1055                 1060                 1065             


Arg Gly  Asp Asn Lys Glu Tyr  Glu Tyr Ser Val Glu  Cys Gln Glu 
    1070                 1075                 1080             


Asp Ser  Ala Cys Pro Ala Ala  Glu Glu Ser Leu Pro  Ile Glu Val 
    1085                 1090                 1095             


Met Val  Asp Ala Val His Lys  Leu Lys Tyr Glu Asn  Tyr Thr Ser 
    1100                 1105                 1110             


Ser Phe  Phe Ile Arg Asp Ile  Ile Lys Pro Asp Pro  Pro Lys Asn 
    1115                 1120                 1125             


Leu Gln  Leu Lys Pro Leu Lys  Asn Ser Arg Gln Val  Glu Val Ser 
    1130                 1135                 1140             


Trp Glu  Tyr Pro Asp Thr Trp  Ser Thr Pro His Ser  Tyr Phe Ser 
    1145                 1150                 1155             


Leu Thr  Phe Cys Val Gln Val  Gln Gly Lys Ser Lys  Arg Glu Lys 
    1160                 1165                 1170             


Lys Asp  Arg Val Phe Thr Asp  Lys Thr Ser Ala Thr  Val Ile Cys 
    1175                 1180                 1185             


Arg Lys  Asn Ala Ser Ile Ser  Val Arg Ala Gln Asp  Arg Tyr Tyr 
    1190                 1195                 1200             


Ser Ser  Ser Trp Ser Glu Trp  Ala Ser Val Pro Cys  Ser Gly Gly 
    1205                 1210                 1215             


Ser Gly  Gly Gly Ser Gly Gly  Gly Ser Gly Gly Gly  Ser Arg Asn 
    1220                 1225                 1230             


Leu Pro  Val Ala Thr Pro Asp  Pro Gly Met Phe Pro  Cys Leu His 
    1235                 1240                 1245             


His Ser  Gln Asn Leu Leu Arg  Ala Val Ser Asn Met  Leu Gln Lys 
    1250                 1255                 1260             


Ala Arg  Gln Thr Leu Glu Phe  Tyr Pro Cys Thr Ser  Glu Glu Ile 
    1265                 1270                 1275             


Asp His  Glu Asp Ile Thr Lys  Asp Lys Thr Ser Thr  Val Glu Ala 
    1280                 1285                 1290             


Cys Leu  Pro Leu Glu Leu Thr  Lys Asn Glu Ser Cys  Leu Asn Ser 
    1295                 1300                 1305             


Arg Glu  Thr Ser Phe Ile Thr  Asn Gly Ser Cys Leu  Ala Ser Arg 
    1310                 1315                 1320             


Lys Thr  Ser Phe Met Met Ala  Leu Cys Leu Ser Ser  Ile Tyr Glu 
    1325                 1330                 1335             


Asp Leu  Lys Met Tyr Gln Val  Glu Phe Lys Thr Met  Asn Ala Lys 
    1340                 1345                 1350             


Leu Leu  Met Asp Pro Lys Arg  Gln Ile Phe Leu Asp  Gln Asn Met 
    1355                 1360                 1365             


Leu Ala  Val Ile Asp Glu Leu  Met Gln Ala Leu Asn  Phe Asn Ser 
    1370                 1375                 1380             


Glu Thr  Val Pro Gln Lys Ser  Ser Leu Glu Glu Pro  Asp Phe Tyr 
    1385                 1390                 1395             


Lys Thr  Lys Ile Lys Leu Cys  Ile Leu Leu His Ala  Phe Arg Ile 
    1400                 1405                 1410             


Arg Ala  Val Thr Ile Asp Arg  Val Met Ser Tyr Leu  Asn Ala Ser 
    1415                 1420                 1425             


His His  His His His His His  His His His 
    1430                 1435             


<210> 51
<211> 1425
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 51
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln 
            20                  25                  30          


Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly 
        35                  40                  45              


Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys 
    50                  55                  60                  


Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu 
65                  70                  75                  80  


Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser 
                85                  90                  95      


Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val 
            100                 105                 110         


Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr 
        115                 120                 125             


Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr 
    130                 135                 140                 


Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Ser Gln Glu Gly Ala Leu Pro Arg Pro Ser Ile Ser Ala Glu 
                165                 170                 175     


Pro Gly Thr Val Ile Ser Pro Gly Ser His Val Thr Phe Met Cys Arg 
            180                 185                 190         


Gly Pro Val Gly Val Gln Thr Phe Arg Leu Glu Arg Glu Asp Arg Ala 
        195                 200                 205             


Lys Tyr Lys Asp Ser Tyr Asn Val Phe Arg Leu Gly Pro Ser Glu Ser 
    210                 215                 220                 


Glu Ala Arg Phe His Ile Asp Ser Val Ser Glu Gly Asn Ala Gly Leu 
225                 230                 235                 240 


Tyr Arg Cys Leu Tyr Tyr Lys Pro Pro Gly Trp Ser Glu His Ser Asp 
                245                 250                 255     


Phe Leu Glu Leu Leu Val Lys Glu Ser Ser Gly Gly Pro Asp Ser Pro 
            260                 265                 270         


Asp Thr Glu Pro Gly Ser Ser Ala Gly Thr Val Pro Gly Thr Glu Ala 
        275                 280                 285             


Ser Gly Phe Asp Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Ser Asp 
    290                 295                 300                 


Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu 
305                 310                 315                 320 


Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln 
                325                 330                 335     


Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe 
            340                 345                 350         


Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser 
        355                 360                 365             


Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg 
    370                 375                 380                 


Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu 
385                 390                 395                 400 


Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro 
                405                 410                 415     


Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp 
            420                 425                 430         


Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg 
        435                 440                 445             


His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr 
    450                 455                 460                 


Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys 
465                 470                 475                 480 


Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser 
                485                 490                 495     


Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg 
            500                 505                 510         


Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys 
        515                 520                 525             


Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val 
    530                 535                 540                 


His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg 
545                 550                 555                 560 


Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser 
                565                 570                 575     


Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys 
            580                 585                 590         


Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu 
        595                 600                 605             


Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu 
    610                 615                 620                 


Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg 
625                 630                 635                 640 


His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr 
                645                 650                 655     


Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys 
            660                 665                 670         


Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln 
        675                 680                 685             


Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr 
    690                 695                 700                 


Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln 
705                 710                 715                 720 


Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val 
                725                 730                 735     


Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala 
            740                 745                 750         


Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu 
        755                 760                 765             


Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu 
    770                 775                 780                 


Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr 
785                 790                 795                 800 


Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile 
                805                 810                 815     


Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu 
            820                 825                 830         


Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys 
        835                 840                 845             


Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala 
    850                 855                 860                 


Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala 
865                 870                 875                 880 


Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly Gly Ser Gly Gly Gly 
                885                 890                 895     


Ser Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp 
            900                 905                 910         


Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro 
        915                 920                 925             


Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu 
    930                 935                 940                 


Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala 
945                 950                 955                 960 


Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu 
                965                 970                 975     


Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu 
            980                 985                 990         


Lys Asp Gln Lys Glu Pro Lys Asn  Lys Thr Phe Leu Arg  Cys Glu Ala 
        995                 1000                 1005             


Lys Asn  Tyr Ser Gly Arg Phe  Thr Cys Trp Trp Leu  Thr Thr Ile 
    1010                 1015                 1020             


Ser Thr  Asp Leu Thr Phe Ser  Val Lys Ser Ser Arg  Gly Ser Ser 
    1025                 1030                 1035             


Asp Pro  Gln Gly Val Thr Cys  Gly Ala Ala Thr Leu  Ser Ala Glu 
    1040                 1045                 1050             


Arg Val  Arg Gly Asp Asn Lys  Glu Tyr Glu Tyr Ser  Val Glu Cys 
    1055                 1060                 1065             


Gln Glu  Asp Ser Ala Cys Pro  Ala Ala Glu Glu Ser  Leu Pro Ile 
    1070                 1075                 1080             


Glu Val  Met Val Asp Ala Val  His Lys Leu Lys Tyr  Glu Asn Tyr 
    1085                 1090                 1095             


Thr Ser  Ser Phe Phe Ile Arg  Asp Ile Ile Lys Pro  Asp Pro Pro 
    1100                 1105                 1110             


Lys Asn  Leu Gln Leu Lys Pro  Leu Lys Asn Ser Arg  Gln Val Glu 
    1115                 1120                 1125             


Val Ser  Trp Glu Tyr Pro Asp  Thr Trp Ser Thr Pro  His Ser Tyr 
    1130                 1135                 1140             


Phe Ser  Leu Thr Phe Cys Val  Gln Val Gln Gly Lys  Ser Lys Arg 
    1145                 1150                 1155             


Glu Lys  Lys Asp Arg Val Phe  Thr Asp Lys Thr Ser  Ala Thr Val 
    1160                 1165                 1170             


Ile Cys  Arg Lys Asn Ala Ser  Ile Ser Val Arg Ala  Gln Asp Arg 
    1175                 1180                 1185             


Tyr Tyr  Ser Ser Ser Trp Ser  Glu Trp Ala Ser Val  Pro Cys Ser 
    1190                 1195                 1200             


Gly Gly  Ser Gly Gly Gly Ser  Gly Gly Gly Ser Gly  Gly Gly Ser 
    1205                 1210                 1215             


Arg Asn  Leu Pro Val Ala Thr  Pro Asp Pro Gly Met  Phe Pro Cys 
    1220                 1225                 1230             


Leu His  His Ser Gln Asn Leu  Leu Arg Ala Val Ser  Asn Met Leu 
    1235                 1240                 1245             


Gln Lys  Ala Arg Gln Thr Leu  Glu Phe Tyr Pro Cys  Thr Ser Glu 
    1250                 1255                 1260             


Glu Ile  Asp His Glu Asp Ile  Thr Lys Asp Lys Thr  Ser Thr Val 
    1265                 1270                 1275             


Glu Ala  Cys Leu Pro Leu Glu  Leu Thr Lys Asn Glu  Ser Cys Leu 
    1280                 1285                 1290             


Asn Ser  Arg Glu Thr Ser Phe  Ile Thr Asn Gly Ser  Cys Leu Ala 
    1295                 1300                 1305             


Ser Arg  Lys Thr Ser Phe Met  Met Ala Leu Cys Leu  Ser Ser Ile 
    1310                 1315                 1320             


Tyr Glu  Asp Leu Lys Met Tyr  Gln Val Glu Phe Lys  Thr Met Asn 
    1325                 1330                 1335             


Ala Lys  Leu Leu Met Asp Pro  Lys Arg Gln Ile Phe  Leu Asp Gln 
    1340                 1345                 1350             


Asn Met  Leu Ala Val Ile Asp  Glu Leu Met Gln Ala  Leu Asn Phe 
    1355                 1360                 1365             


Asn Ser  Glu Thr Val Pro Gln  Lys Ser Ser Leu Glu  Glu Pro Asp 
    1370                 1375                 1380             


Phe Tyr  Lys Thr Lys Ile Lys  Leu Cys Ile Leu Leu  His Ala Phe 
    1385                 1390                 1395             


Arg Ile  Arg Ala Val Thr Ile  Asp Arg Val Met Ser  Tyr Leu Asn 
    1400                 1405                 1410             


Ala Ser  His His His His His  His His His His His  
    1415                 1420                 1425 


<210> 52
<211> 1616
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 52
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln 
            20                  25                  30          


Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly 
        35                  40                  45              


Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys 
    50                  55                  60                  


Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu 
65                  70                  75                  80  


Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser 
                85                  90                  95      


Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val 
            100                 105                 110         


Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr 
        115                 120                 125             


Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr 
    130                 135                 140                 


Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Ser Ser Gly Gln Tyr Tyr Asp Tyr Asp Phe Pro Leu Ser Ile 
                165                 170                 175     


Tyr Gly Gln Ser Ser Pro Asn Cys Ala Pro Glu Cys Asn Cys Pro Glu 
            180                 185                 190         


Ser Tyr Pro Ser Ala Met Tyr Cys Asp Glu Leu Lys Leu Lys Ser Val 
        195                 200                 205             


Pro Met Val Pro Pro Gly Ile Lys Tyr Leu Tyr Leu Arg Asn Asn Gln 
    210                 215                 220                 


Ile Asp His Ile Asp Glu Lys Ala Phe Glu Asn Val Thr Asp Leu Gln 
225                 230                 235                 240 


Trp Leu Ile Leu Asp His Asn Leu Leu Glu Asn Ser Lys Ile Lys Gly 
                245                 250                 255     


Arg Val Phe Ser Lys Leu Lys Gln Leu Lys Lys Leu His Ile Asn His 
            260                 265                 270         


Asn Asn Leu Thr Glu Ser Val Gly Pro Leu Pro Lys Ser Leu Glu Asp 
        275                 280                 285             


Leu Gln Leu Thr His Asn Lys Ile Thr Lys Leu Gly Ser Phe Glu Gly 
    290                 295                 300                 


Leu Val Asn Leu Thr Phe Ile His Leu Gln His Asn Arg Leu Lys Glu 
305                 310                 315                 320 


Asp Ala Val Ser Ala Ala Phe Lys Gly Leu Lys Ser Leu Glu Tyr Leu 
                325                 330                 335     


Asp Leu Ser Phe Asn Gln Ile Ala Arg Leu Pro Ser Gly Leu Pro Val 
            340                 345                 350         


Ser Leu Leu Thr Leu Tyr Leu Asp Asn Asn Lys Ile Ser Asn Ile Pro 
        355                 360                 365             


Asp Glu Tyr Phe Lys Arg Phe Asn Ala Leu Gln Tyr Leu Arg Leu Ser 
    370                 375                 380                 


His Asn Glu Leu Ala Asp Ser Gly Ile Pro Gly Asn Ser Phe Asn Val 
385                 390                 395                 400 


Ser Ser Leu Val Glu Leu Asp Leu Ser Tyr Asn Lys Leu Lys Asn Ile 
                405                 410                 415     


Pro Thr Val Asn Glu Asn Leu Glu Asn Tyr Tyr Leu Glu Val Asn Gln 
            420                 425                 430         


Leu Glu Lys Phe Asp Ile Lys Ser Phe Cys Lys Ile Leu Gly Pro Leu 
        435                 440                 445             


Ser Tyr Ser Lys Ile Lys His Leu Arg Leu Asp Gly Asn Arg Ile Ser 
    450                 455                 460                 


Glu Thr Ser Leu Pro Pro Asp Met Tyr Glu Cys Leu Arg Val Ala Asn 
465                 470                 475                 480 


Glu Val Thr Leu Asn Gly Gly Gly Gly Ser Gly Gly Gly Ser Asp Ala 
                485                 490                 495     


His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn 
            500                 505                 510         


Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys 
        515                 520                 525             


Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala 
    530                 535                 540                 


Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu 
545                 550                 555                 560 


His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu 
                565                 570                 575     


Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg 
            580                 585                 590         


Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg 
        595                 600                 605             


Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn 
    610                 615                 620                 


Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His 
625                 630                 635                 640 


Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys 
                645                 650                 655     


Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu 
            660                 665                 670         


Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala 
        675                 680                 685             


Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala 
    690                 695                 700                 


Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala 
705                 710                 715                 720 


Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His 
                725                 730                 735     


Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala 
            740                 745                 750         


Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys 
        755                 760                 765             


Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile 
    770                 775                 780                 


Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala 
785                 790                 795                 800 


Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala 
                805                 810                 815     


Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His 
            820                 825                 830         


Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu 
        835                 840                 845             


Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr 
    850                 855                 860                 


Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn 
865                 870                 875                 880 


Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys 
                885                 890                 895     


Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val 
            900                 905                 910         


Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly 
        915                 920                 925             


Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu 
    930                 935                 940                 


Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys 
945                 950                 955                 960 


Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val 
                965                 970                 975     


Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val 
            980                 985                 990         


Pro Lys Glu Phe Asn Ala Glu Thr  Phe Thr Phe His Ala  Asp Ile Cys 
        995                 1000                 1005             


Thr Leu  Ser Glu Lys Glu Arg  Gln Ile Lys Lys Gln  Thr Ala Leu 
    1010                 1015                 1020             


Val Glu  Leu Val Lys His Lys  Pro Lys Ala Thr Lys  Glu Gln Leu 
    1025                 1030                 1035             


Lys Ala  Val Met Asp Asp Phe  Ala Ala Phe Val Glu  Lys Cys Cys 
    1040                 1045                 1050             


Lys Ala  Asp Asp Lys Glu Thr  Cys Phe Ala Glu Glu  Gly Lys Lys 
    1055                 1060                 1065             


Leu Val  Ala Ala Ser Gln Ala  Ala Leu Gly Leu Gly  Gly Gly Gly 
    1070                 1075                 1080             


Ser Gly  Gly Gly Ser Ile Trp  Glu Leu Lys Lys Asp  Val Tyr Val 
    1085                 1090                 1095             


Val Glu  Leu Asp Trp Tyr Pro  Asp Ala Pro Gly Glu  Met Val Val 
    1100                 1105                 1110             


Leu Thr  Cys Asp Thr Pro Glu  Glu Asp Gly Ile Thr  Trp Thr Leu 
    1115                 1120                 1125             


Asp Gln  Ser Ser Glu Val Leu  Gly Ser Gly Lys Thr  Leu Thr Ile 
    1130                 1135                 1140             


Gln Val  Lys Glu Phe Gly Asp  Ala Gly Gln Tyr Thr  Cys His Lys 
    1145                 1150                 1155             


Gly Gly  Glu Val Leu Ser His  Ser Leu Leu Leu Leu  His Lys Lys 
    1160                 1165                 1170             


Glu Asp  Gly Ile Trp Ser Thr  Asp Ile Leu Lys Asp  Gln Lys Glu 
    1175                 1180                 1185             


Pro Lys  Asn Lys Thr Phe Leu  Arg Cys Glu Ala Lys  Asn Tyr Ser 
    1190                 1195                 1200             


Gly Arg  Phe Thr Cys Trp Trp  Leu Thr Thr Ile Ser  Thr Asp Leu 
    1205                 1210                 1215             


Thr Phe  Ser Val Lys Ser Ser  Arg Gly Ser Ser Asp  Pro Gln Gly 
    1220                 1225                 1230             


Val Thr  Cys Gly Ala Ala Thr  Leu Ser Ala Glu Arg  Val Arg Gly 
    1235                 1240                 1245             


Asp Asn  Lys Glu Tyr Glu Tyr  Ser Val Glu Cys Gln  Glu Asp Ser 
    1250                 1255                 1260             


Ala Cys  Pro Ala Ala Glu Glu  Ser Leu Pro Ile Glu  Val Met Val 
    1265                 1270                 1275             


Asp Ala  Val His Lys Leu Lys  Tyr Glu Asn Tyr Thr  Ser Ser Phe 
    1280                 1285                 1290             


Phe Ile  Arg Asp Ile Ile Lys  Pro Asp Pro Pro Lys  Asn Leu Gln 
    1295                 1300                 1305             


Leu Lys  Pro Leu Lys Asn Ser  Arg Gln Val Glu Val  Ser Trp Glu 
    1310                 1315                 1320             


Tyr Pro  Asp Thr Trp Ser Thr  Pro His Ser Tyr Phe  Ser Leu Thr 
    1325                 1330                 1335             


Phe Cys  Val Gln Val Gln Gly  Lys Ser Lys Arg Glu  Lys Lys Asp 
    1340                 1345                 1350             


Arg Val  Phe Thr Asp Lys Thr  Ser Ala Thr Val Ile  Cys Arg Lys 
    1355                 1360                 1365             


Asn Ala  Ser Ile Ser Val Arg  Ala Gln Asp Arg Tyr  Tyr Ser Ser 
    1370                 1375                 1380             


Ser Trp  Ser Glu Trp Ala Ser  Val Pro Cys Ser Gly  Gly Ser Gly 
    1385                 1390                 1395             


Gly Gly  Ser Gly Gly Gly Ser  Gly Gly Gly Ser Arg  Asn Leu Pro 
    1400                 1405                 1410             


Val Ala  Thr Pro Asp Pro Gly  Met Phe Pro Cys Leu  His His Ser 
    1415                 1420                 1425             


Gln Asn  Leu Leu Arg Ala Val  Ser Asn Met Leu Gln  Lys Ala Arg 
    1430                 1435                 1440             


Gln Thr  Leu Glu Phe Tyr Pro  Cys Thr Ser Glu Glu  Ile Asp His 
    1445                 1450                 1455             


Glu Asp  Ile Thr Lys Asp Lys  Thr Ser Thr Val Glu  Ala Cys Leu 
    1460                 1465                 1470             


Pro Leu  Glu Leu Thr Lys Asn  Glu Ser Cys Leu Asn  Ser Arg Glu 
    1475                 1480                 1485             


Thr Ser  Phe Ile Thr Asn Gly  Ser Cys Leu Ala Ser  Arg Lys Thr 
    1490                 1495                 1500             


Ser Phe  Met Met Ala Leu Cys  Leu Ser Ser Ile Tyr  Glu Asp Leu 
    1505                 1510                 1515             


Lys Met  Tyr Gln Val Glu Phe  Lys Thr Met Asn Ala  Lys Leu Leu 
    1520                 1525                 1530             


Met Asp  Pro Lys Arg Gln Ile  Phe Leu Asp Gln Asn  Met Leu Ala 
    1535                 1540                 1545             


Val Ile  Asp Glu Leu Met Gln  Ala Leu Asn Phe Asn  Ser Glu Thr 
    1550                 1555                 1560             


Val Pro  Gln Lys Ser Ser Leu  Glu Glu Pro Asp Phe  Tyr Lys Thr 
    1565                 1570                 1575             


Lys Ile  Lys Leu Cys Ile Leu  Leu His Ala Phe Arg  Ile Arg Ala 
    1580                 1585                 1590             


Val Thr  Ile Asp Arg Val Met  Ser Tyr Leu Asn Ala  Ser His His 
    1595                 1600                 1605             


His His  His His His His His  His 
    1610                 1615     


<210> 53
<211> 968
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 53
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln 
            20                  25                  30          


Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly 
        35                  40                  45              


Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys 
    50                  55                  60                  


Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu 
65                  70                  75                  80  


Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser 
                85                  90                  95      


Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val 
            100                 105                 110         


Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr 
        115                 120                 125             


Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr 
    130                 135                 140                 


Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Ser Gln Glu Glu Asp Leu Pro Arg Pro Ser Ile Ser Ala Glu 
                165                 170                 175     


Pro Gly Thr Val Ile Pro Leu Gly Ser His Val Thr Phe Val Cys Arg 
            180                 185                 190         


Gly Pro Val Gly Val Gln Thr Phe Arg Leu Glu Arg Glu Ser Arg Ser 
        195                 200                 205             


Thr Tyr Asn Asp Thr Glu Asp Val Ser Gln Ala Ser Pro Ser Glu Ser 
    210                 215                 220                 


Glu Ala Arg Phe Arg Ile Asp Ser Val Ser Glu Gly Asn Ala Gly Pro 
225                 230                 235                 240 


Tyr Arg Cys Ile Tyr Tyr Lys Pro Pro Lys Trp Ser Glu Gln Ser Asp 
                245                 250                 255     


Tyr Leu Glu Leu Leu Val Lys Glu Thr Ser Gly Gly Pro Asp Ser Pro 
            260                 265                 270         


Asp Thr Glu Pro Gly Ser Ser Ala Gly Pro Thr Gln Arg Pro Ser Asp 
        275                 280                 285             


Asn Ser His Asn Glu His Ala Pro Ala Ser Gln Gly Leu Lys Ala Glu 
    290                 295                 300                 


His Leu Tyr Gly Gly Gly Gly Ser Gly Gly Gly Ser Lys Val Gln Leu 
305                 310                 315                 320 


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
                325                 330                 335     


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Thr Trp 
            340                 345                 350         


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser 
        355                 360                 365             


Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Arg Gly Arg Phe 
    370                 375                 380                 


Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
385                 390                 395                 400 


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly 
                405                 410                 415     


Ser Leu Ser Pro Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Ser Ile Trp Glu Leu Lys Lys Asp Val 
        435                 440                 445             


Tyr Val Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val 
    450                 455                 460                 


Val Leu Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu 
465                 470                 475                 480 


Asp Gln Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln 
                485                 490                 495     


Val Lys Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly 
            500                 505                 510         


Glu Val Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly 
        515                 520                 525             


Ile Trp Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys 
    530                 535                 540                 


Thr Phe Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys 
545                 550                 555                 560 


Trp Trp Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser 
                565                 570                 575     


Ser Arg Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr 
            580                 585                 590         


Leu Ser Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser 
        595                 600                 605             


Val Glu Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu 
    610                 615                 620                 


Pro Ile Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn 
625                 630                 635                 640 


Tyr Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro 
                645                 650                 655     


Lys Asn Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val 
            660                 665                 670         


Ser Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser 
        675                 680                 685             


Leu Thr Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys 
    690                 695                 700                 


Asp Arg Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys 
705                 710                 715                 720 


Asn Ala Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser 
                725                 730                 735     


Trp Ser Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Ser Gly Gly Gly 
            740                 745                 750         


Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr 
        755                 760                 765             


Pro Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu 
    770                 775                 780                 


Arg Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe 
785                 790                 795                 800 


Tyr Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp 
                805                 810                 815     


Lys Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn 
            820                 825                 830         


Glu Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser 
        835                 840                 845             


Cys Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser 
    850                 855                 860                 


Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met 
865                 870                 875                 880 


Asn Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln 
                885                 890                 895     


Asn Met Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn 
            900                 905                 910         


Ser Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr 
        915                 920                 925             


Lys Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg 
    930                 935                 940                 


Ala Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser His His 
945                 950                 955                 960 


His His His His His His His His 
                965             


<210> 54
<211> 955
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 54
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln 
            20                  25                  30          


Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly 
        35                  40                  45              


Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys 
    50                  55                  60                  


Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu 
65                  70                  75                  80  


Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser 
                85                  90                  95      


Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val 
            100                 105                 110         


Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr 
        115                 120                 125             


Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr 
    130                 135                 140                 


Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Ser Gln Glu Gly Ala Leu Pro Arg Pro Ser Ile Ser Ala Glu 
                165                 170                 175     


Pro Gly Thr Val Ile Ser Pro Gly Ser His Val Thr Phe Met Cys Arg 
            180                 185                 190         


Gly Pro Val Gly Val Gln Thr Phe Arg Leu Glu Arg Glu Asp Arg Ala 
        195                 200                 205             


Lys Tyr Lys Asp Ser Tyr Asn Val Phe Arg Leu Gly Pro Ser Glu Ser 
    210                 215                 220                 


Glu Ala Arg Phe His Ile Asp Ser Val Ser Glu Gly Asn Ala Gly Leu 
225                 230                 235                 240 


Tyr Arg Cys Leu Tyr Tyr Lys Pro Pro Gly Trp Ser Glu His Ser Asp 
                245                 250                 255     


Phe Leu Glu Leu Leu Val Lys Glu Ser Ser Gly Gly Pro Asp Ser Pro 
            260                 265                 270         


Asp Thr Glu Pro Gly Ser Ser Ala Gly Thr Val Pro Gly Thr Glu Ala 
        275                 280                 285             


Ser Gly Phe Asp Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Ser Lys 
    290                 295                 300                 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
305                 310                 315                 320 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
                325                 330                 335     


Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
            340                 345                 350         


Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Arg 
        355                 360                 365             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
    370                 375                 380                 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
385                 390                 395                 400 


Ile Gly Gly Ser Leu Ser Pro Ser Ser Gln Gly Thr Leu Val Thr Val 
                405                 410                 415     


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Ile Trp Glu Leu Lys 
            420                 425                 430         


Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly 
        435                 440                 445             


Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr 
    450                 455                 460                 


Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu 
465                 470                 475                 480 


Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His 
                485                 490                 495     


Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu Leu Leu His Lys Lys 
            500                 505                 510         


Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro 
        515                 520                 525             


Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg 
    530                 535                 540                 


Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser 
545                 550                 555                 560 


Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly 
                565                 570                 575     


Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr 
            580                 585                 590         


Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu 
        595                 600                 605             


Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala Val His Lys Leu Lys 
    610                 615                 620                 


Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro 
625                 630                 635                 640 


Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln 
                645                 650                 655     


Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser 
            660                 665                 670         


Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg 
        675                 680                 685             


Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile 
    690                 695                 700                 


Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr 
705                 710                 715                 720 


Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Ser 
                725                 730                 735     


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Asn Leu Pro 
            740                 745                 750         


Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln 
        755                 760                 765             


Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr 
    770                 775                 780                 


Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile 
785                 790                 795                 800 


Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu 
                805                 810                 815     


Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr 
            820                 825                 830         


Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu 
        835                 840                 845             


Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe 
    850                 855                 860                 


Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe 
865                 870                 875                 880 


Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu 
                885                 890                 895     


Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro 
            900                 905                 910         


Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe 
        915                 920                 925             


Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala 
    930                 935                 940                 


Ser His His His His His His His His His His 
945                 950                 955 


<210> 55
<211> 1146
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 55
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln 
            20                  25                  30          


Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly 
        35                  40                  45              


Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys 
    50                  55                  60                  


Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu 
65                  70                  75                  80  


Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser 
                85                  90                  95      


Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val 
            100                 105                 110         


Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr 
        115                 120                 125             


Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr 
    130                 135                 140                 


Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Ser Ser Gly Gln Tyr Tyr Asp Tyr Asp Phe Pro Leu Ser Ile 
                165                 170                 175     


Tyr Gly Gln Ser Ser Pro Asn Cys Ala Pro Glu Cys Asn Cys Pro Glu 
            180                 185                 190         


Ser Tyr Pro Ser Ala Met Tyr Cys Asp Glu Leu Lys Leu Lys Ser Val 
        195                 200                 205             


Pro Met Val Pro Pro Gly Ile Lys Tyr Leu Tyr Leu Arg Asn Asn Gln 
    210                 215                 220                 


Ile Asp His Ile Asp Glu Lys Ala Phe Glu Asn Val Thr Asp Leu Gln 
225                 230                 235                 240 


Trp Leu Ile Leu Asp His Asn Leu Leu Glu Asn Ser Lys Ile Lys Gly 
                245                 250                 255     


Arg Val Phe Ser Lys Leu Lys Gln Leu Lys Lys Leu His Ile Asn His 
            260                 265                 270         


Asn Asn Leu Thr Glu Ser Val Gly Pro Leu Pro Lys Ser Leu Glu Asp 
        275                 280                 285             


Leu Gln Leu Thr His Asn Lys Ile Thr Lys Leu Gly Ser Phe Glu Gly 
    290                 295                 300                 


Leu Val Asn Leu Thr Phe Ile His Leu Gln His Asn Arg Leu Lys Glu 
305                 310                 315                 320 


Asp Ala Val Ser Ala Ala Phe Lys Gly Leu Lys Ser Leu Glu Tyr Leu 
                325                 330                 335     


Asp Leu Ser Phe Asn Gln Ile Ala Arg Leu Pro Ser Gly Leu Pro Val 
            340                 345                 350         


Ser Leu Leu Thr Leu Tyr Leu Asp Asn Asn Lys Ile Ser Asn Ile Pro 
        355                 360                 365             


Asp Glu Tyr Phe Lys Arg Phe Asn Ala Leu Gln Tyr Leu Arg Leu Ser 
    370                 375                 380                 


His Asn Glu Leu Ala Asp Ser Gly Ile Pro Gly Asn Ser Phe Asn Val 
385                 390                 395                 400 


Ser Ser Leu Val Glu Leu Asp Leu Ser Tyr Asn Lys Leu Lys Asn Ile 
                405                 410                 415     


Pro Thr Val Asn Glu Asn Leu Glu Asn Tyr Tyr Leu Glu Val Asn Gln 
            420                 425                 430         


Leu Glu Lys Phe Asp Ile Lys Ser Phe Cys Lys Ile Leu Gly Pro Leu 
        435                 440                 445             


Ser Tyr Ser Lys Ile Lys His Leu Arg Leu Asp Gly Asn Arg Ile Ser 
    450                 455                 460                 


Glu Thr Ser Leu Pro Pro Asp Met Tyr Glu Cys Leu Arg Val Ala Asn 
465                 470                 475                 480 


Glu Val Thr Leu Asn Gly Gly Gly Gly Ser Gly Gly Gly Ser Lys Val 
                485                 490                 495     


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
            500                 505                 510         


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
        515                 520                 525             


Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
    530                 535                 540                 


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Arg Gly 
545                 550                 555                 560 


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
                565                 570                 575     


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
            580                 585                 590         


Gly Gly Ser Leu Ser Pro Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
        595                 600                 605             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Ile Trp Glu Leu Lys Lys 
    610                 615                 620                 


Asp Val Tyr Val Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu 
625                 630                 635                 640 


Met Val Val Leu Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp 
                645                 650                 655     


Thr Leu Asp Gln Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr 
            660                 665                 670         


Ile Gln Val Lys Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys 
        675                 680                 685             


Gly Gly Glu Val Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu 
    690                 695                 700                 


Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys 
705                 710                 715                 720 


Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe 
                725                 730                 735     


Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val 
            740                 745                 750         


Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala 
        755                 760                 765             


Ala Thr Leu Ser Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu 
    770                 775                 780                 


Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu 
785                 790                 795                 800 


Ser Leu Pro Ile Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr 
                805                 810                 815     


Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp 
            820                 825                 830         


Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val 
        835                 840                 845             


Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr 
    850                 855                 860                 


Phe Ser Leu Thr Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu 
865                 870                 875                 880 


Lys Lys Asp Arg Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys 
                885                 890                 895     


Arg Lys Asn Ala Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser 
            900                 905                 910         


Ser Ser Trp Ser Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Ser Gly 
        915                 920                 925             


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Asn Leu Pro Val 
    930                 935                 940                 


Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn 
945                 950                 955                 960 


Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu 
                965                 970                 975     


Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr 
            980                 985                 990         


Lys Asp Lys Thr Ser Thr Val Glu  Ala Cys Leu Pro Leu  Glu Leu Thr 
        995                 1000                 1005             


Lys Asn  Glu Ser Cys Leu Asn  Ser Arg Glu Thr Ser  Phe Ile Thr 
    1010                 1015                 1020             


Asn Gly  Ser Cys Leu Ala Ser  Arg Lys Thr Ser Phe  Met Met Ala 
    1025                 1030                 1035             


Leu Cys  Leu Ser Ser Ile Tyr  Glu Asp Leu Lys Met  Tyr Gln Val 
    1040                 1045                 1050             


Glu Phe  Lys Thr Met Asn Ala  Lys Leu Leu Met Asp  Pro Lys Arg 
    1055                 1060                 1065             


Gln Ile  Phe Leu Asp Gln Asn  Met Leu Ala Val Ile  Asp Glu Leu 
    1070                 1075                 1080             


Met Gln  Ala Leu Asn Phe Asn  Ser Glu Thr Val Pro  Gln Lys Ser 
    1085                 1090                 1095             


Ser Leu  Glu Glu Pro Asp Phe  Tyr Lys Thr Lys Ile  Lys Leu Cys 
    1100                 1105                 1110             


Ile Leu  Leu His Ala Phe Arg  Ile Arg Ala Val Thr  Ile Asp Arg 
    1115                 1120                 1125             


Val Met  Ser Tyr Leu Asn Ala  Ser His His His His  His His His 
    1130                 1135                 1140             


His His  His 
    1145     


<210> 56
<211> 1438
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 56
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln 
            20                  25                  30          


Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly 
        35                  40                  45              


Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys 
    50                  55                  60                  


Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu 
65                  70                  75                  80  


Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser 
                85                  90                  95      


Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val 
            100                 105                 110         


Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr 
        115                 120                 125             


Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr 
    130                 135                 140                 


Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp 
                165                 170                 175     


Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln 
            180                 185                 190         


Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu 
        195                 200                 205             


Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn 
    210                 215                 220                 


Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val 
225                 230                 235                 240 


Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys 
                245                 250                 255     


Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn 
            260                 265                 270         


Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr 
        275                 280                 285             


Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu 
    290                 295                 300                 


Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe 
305                 310                 315                 320 


Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp 
                325                 330                 335     


Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly 
            340                 345                 350         


Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys 
        355                 360                 365             


Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln 
    370                 375                 380                 


Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp 
385                 390                 395                 400 


Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys 
                405                 410                 415     


Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp 
            420                 425                 430         


Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu 
        435                 440                 445             


Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp 
    450                 455                 460                 


Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys 
465                 470                 475                 480 


Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu 
                485                 490                 495     


Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu 
            500                 505                 510         


Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp 
        515                 520                 525             


Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val 
    530                 535                 540                 


Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln 
545                 550                 555                 560 


Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys 
                565                 570                 575     


Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn 
            580                 585                 590         


Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg 
        595                 600                 605             


Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys 
    610                 615                 620                 


Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys 
625                 630                 635                 640 


Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val 
                645                 650                 655     


Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe 
            660                 665                 670         


His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys 
        675                 680                 685             


Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys 
    690                 695                 700                 


Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys 
705                 710                 715                 720 


Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys 
                725                 730                 735     


Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly Gly 
            740                 745                 750         


Ser Gly Gly Gly Ser Gln Glu Glu Asp Leu Pro Arg Pro Ser Ile Ser 
        755                 760                 765             


Ala Glu Pro Gly Thr Val Ile Pro Leu Gly Ser His Val Thr Phe Val 
    770                 775                 780                 


Cys Arg Gly Pro Val Gly Val Gln Thr Phe Arg Leu Glu Arg Glu Ser 
785                 790                 795                 800 


Arg Ser Thr Tyr Asn Asp Thr Glu Asp Val Ser Gln Ala Ser Pro Ser 
                805                 810                 815     


Glu Ser Glu Ala Arg Phe Arg Ile Asp Ser Val Ser Glu Gly Asn Ala 
            820                 825                 830         


Gly Pro Tyr Arg Cys Ile Tyr Tyr Lys Pro Pro Lys Trp Ser Glu Gln 
        835                 840                 845             


Ser Asp Tyr Leu Glu Leu Leu Val Lys Glu Thr Ser Gly Gly Pro Asp 
    850                 855                 860                 


Ser Pro Asp Thr Glu Pro Gly Ser Ser Ala Gly Pro Thr Gln Arg Pro 
865                 870                 875                 880 


Ser Asp Asn Ser His Asn Glu His Ala Pro Ala Ser Gln Gly Leu Lys 
                885                 890                 895     


Ala Glu His Leu Tyr Gly Gly Gly Gly Ser Gly Gly Gly Ser Ile Trp 
            900                 905                 910         


Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr Pro Asp 
        915                 920                 925             


Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu Glu Asp 
    930                 935                 940                 


Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly Ser Gly 
945                 950                 955                 960 


Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly Gln Tyr 
                965                 970                 975     


Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu Leu Leu 
            980                 985                 990         


His Lys Lys Glu Asp Gly Ile Trp  Ser Thr Asp Ile Leu  Lys Asp Gln 
        995                 1000                 1005             


Lys Glu  Pro Lys Asn Lys Thr  Phe Leu Arg Cys Glu  Ala Lys Asn 
    1010                 1015                 1020             


Tyr Ser  Gly Arg Phe Thr Cys  Trp Trp Leu Thr Thr  Ile Ser Thr 
    1025                 1030                 1035             


Asp Leu  Thr Phe Ser Val Lys  Ser Ser Arg Gly Ser  Ser Asp Pro 
    1040                 1045                 1050             


Gln Gly  Val Thr Cys Gly Ala  Ala Thr Leu Ser Ala  Glu Arg Val 
    1055                 1060                 1065             


Arg Gly  Asp Asn Lys Glu Tyr  Glu Tyr Ser Val Glu  Cys Gln Glu 
    1070                 1075                 1080             


Asp Ser  Ala Cys Pro Ala Ala  Glu Glu Ser Leu Pro  Ile Glu Val 
    1085                 1090                 1095             


Met Val  Asp Ala Val His Lys  Leu Lys Tyr Glu Asn  Tyr Thr Ser 
    1100                 1105                 1110             


Ser Phe  Phe Ile Arg Asp Ile  Ile Lys Pro Asp Pro  Pro Lys Asn 
    1115                 1120                 1125             


Leu Gln  Leu Lys Pro Leu Lys  Asn Ser Arg Gln Val  Glu Val Ser 
    1130                 1135                 1140             


Trp Glu  Tyr Pro Asp Thr Trp  Ser Thr Pro His Ser  Tyr Phe Ser 
    1145                 1150                 1155             


Leu Thr  Phe Cys Val Gln Val  Gln Gly Lys Ser Lys  Arg Glu Lys 
    1160                 1165                 1170             


Lys Asp  Arg Val Phe Thr Asp  Lys Thr Ser Ala Thr  Val Ile Cys 
    1175                 1180                 1185             


Arg Lys  Asn Ala Ser Ile Ser  Val Arg Ala Gln Asp  Arg Tyr Tyr 
    1190                 1195                 1200             


Ser Ser  Ser Trp Ser Glu Trp  Ala Ser Val Pro Cys  Ser Gly Gly 
    1205                 1210                 1215             


Ser Gly  Gly Gly Ser Gly Gly  Gly Ser Gly Gly Gly  Ser Arg Asn 
    1220                 1225                 1230             


Leu Pro  Val Ala Thr Pro Asp  Pro Gly Met Phe Pro  Cys Leu His 
    1235                 1240                 1245             


His Ser  Gln Asn Leu Leu Arg  Ala Val Ser Asn Met  Leu Gln Lys 
    1250                 1255                 1260             


Ala Arg  Gln Thr Leu Glu Phe  Tyr Pro Cys Thr Ser  Glu Glu Ile 
    1265                 1270                 1275             


Asp His  Glu Asp Ile Thr Lys  Asp Lys Thr Ser Thr  Val Glu Ala 
    1280                 1285                 1290             


Cys Leu  Pro Leu Glu Leu Thr  Lys Asn Glu Ser Cys  Leu Asn Ser 
    1295                 1300                 1305             


Arg Glu  Thr Ser Phe Ile Thr  Asn Gly Ser Cys Leu  Ala Ser Arg 
    1310                 1315                 1320             


Lys Thr  Ser Phe Met Met Ala  Leu Cys Leu Ser Ser  Ile Tyr Glu 
    1325                 1330                 1335             


Asp Leu  Lys Met Tyr Gln Val  Glu Phe Lys Thr Met  Asn Ala Lys 
    1340                 1345                 1350             


Leu Leu  Met Asp Pro Lys Arg  Gln Ile Phe Leu Asp  Gln Asn Met 
    1355                 1360                 1365             


Leu Ala  Val Ile Asp Glu Leu  Met Gln Ala Leu Asn  Phe Asn Ser 
    1370                 1375                 1380             


Glu Thr  Val Pro Gln Lys Ser  Ser Leu Glu Glu Pro  Asp Phe Tyr 
    1385                 1390                 1395             


Lys Thr  Lys Ile Lys Leu Cys  Ile Leu Leu His Ala  Phe Arg Ile 
    1400                 1405                 1410             


Arg Ala  Val Thr Ile Asp Arg  Val Met Ser Tyr Leu  Asn Ala Ser 
    1415                 1420                 1425             


His His  His His His His His  His His His 
    1430                 1435             


<210> 57
<211> 1425
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 57
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln 
            20                  25                  30          


Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly 
        35                  40                  45              


Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys 
    50                  55                  60                  


Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu 
65                  70                  75                  80  


Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser 
                85                  90                  95      


Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val 
            100                 105                 110         


Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr 
        115                 120                 125             


Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr 
    130                 135                 140                 


Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp 
                165                 170                 175     


Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln 
            180                 185                 190         


Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu 
        195                 200                 205             


Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn 
    210                 215                 220                 


Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val 
225                 230                 235                 240 


Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys 
                245                 250                 255     


Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn 
            260                 265                 270         


Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr 
        275                 280                 285             


Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu 
    290                 295                 300                 


Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe 
305                 310                 315                 320 


Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp 
                325                 330                 335     


Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly 
            340                 345                 350         


Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys 
        355                 360                 365             


Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln 
    370                 375                 380                 


Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp 
385                 390                 395                 400 


Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys 
                405                 410                 415     


Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp 
            420                 425                 430         


Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu 
        435                 440                 445             


Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp 
    450                 455                 460                 


Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys 
465                 470                 475                 480 


Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu 
                485                 490                 495     


Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu 
            500                 505                 510         


Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp 
        515                 520                 525             


Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val 
    530                 535                 540                 


Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln 
545                 550                 555                 560 


Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys 
                565                 570                 575     


Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn 
            580                 585                 590         


Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg 
        595                 600                 605             


Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys 
    610                 615                 620                 


Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys 
625                 630                 635                 640 


Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val 
                645                 650                 655     


Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe 
            660                 665                 670         


His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys 
        675                 680                 685             


Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys 
    690                 695                 700                 


Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys 
705                 710                 715                 720 


Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys 
                725                 730                 735     


Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly Gly 
            740                 745                 750         


Ser Gly Gly Gly Ser Gln Glu Gly Ala Leu Pro Arg Pro Ser Ile Ser 
        755                 760                 765             


Ala Glu Pro Gly Thr Val Ile Ser Pro Gly Ser His Val Thr Phe Met 
    770                 775                 780                 


Cys Arg Gly Pro Val Gly Val Gln Thr Phe Arg Leu Glu Arg Glu Asp 
785                 790                 795                 800 


Arg Ala Lys Tyr Lys Asp Ser Tyr Asn Val Phe Arg Leu Gly Pro Ser 
                805                 810                 815     


Glu Ser Glu Ala Arg Phe His Ile Asp Ser Val Ser Glu Gly Asn Ala 
            820                 825                 830         


Gly Leu Tyr Arg Cys Leu Tyr Tyr Lys Pro Pro Gly Trp Ser Glu His 
        835                 840                 845             


Ser Asp Phe Leu Glu Leu Leu Val Lys Glu Ser Ser Gly Gly Pro Asp 
    850                 855                 860                 


Ser Pro Asp Thr Glu Pro Gly Ser Ser Ala Gly Thr Val Pro Gly Thr 
865                 870                 875                 880 


Glu Ala Ser Gly Phe Asp Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly 
                885                 890                 895     


Ser Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp 
            900                 905                 910         


Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro 
        915                 920                 925             


Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu 
    930                 935                 940                 


Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala 
945                 950                 955                 960 


Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu 
                965                 970                 975     


Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu 
            980                 985                 990         


Lys Asp Gln Lys Glu Pro Lys Asn  Lys Thr Phe Leu Arg  Cys Glu Ala 
        995                 1000                 1005             


Lys Asn  Tyr Ser Gly Arg Phe  Thr Cys Trp Trp Leu  Thr Thr Ile 
    1010                 1015                 1020             


Ser Thr  Asp Leu Thr Phe Ser  Val Lys Ser Ser Arg  Gly Ser Ser 
    1025                 1030                 1035             


Asp Pro  Gln Gly Val Thr Cys  Gly Ala Ala Thr Leu  Ser Ala Glu 
    1040                 1045                 1050             


Arg Val  Arg Gly Asp Asn Lys  Glu Tyr Glu Tyr Ser  Val Glu Cys 
    1055                 1060                 1065             


Gln Glu  Asp Ser Ala Cys Pro  Ala Ala Glu Glu Ser  Leu Pro Ile 
    1070                 1075                 1080             


Glu Val  Met Val Asp Ala Val  His Lys Leu Lys Tyr  Glu Asn Tyr 
    1085                 1090                 1095             


Thr Ser  Ser Phe Phe Ile Arg  Asp Ile Ile Lys Pro  Asp Pro Pro 
    1100                 1105                 1110             


Lys Asn  Leu Gln Leu Lys Pro  Leu Lys Asn Ser Arg  Gln Val Glu 
    1115                 1120                 1125             


Val Ser  Trp Glu Tyr Pro Asp  Thr Trp Ser Thr Pro  His Ser Tyr 
    1130                 1135                 1140             


Phe Ser  Leu Thr Phe Cys Val  Gln Val Gln Gly Lys  Ser Lys Arg 
    1145                 1150                 1155             


Glu Lys  Lys Asp Arg Val Phe  Thr Asp Lys Thr Ser  Ala Thr Val 
    1160                 1165                 1170             


Ile Cys  Arg Lys Asn Ala Ser  Ile Ser Val Arg Ala  Gln Asp Arg 
    1175                 1180                 1185             


Tyr Tyr  Ser Ser Ser Trp Ser  Glu Trp Ala Ser Val  Pro Cys Ser 
    1190                 1195                 1200             


Gly Gly  Ser Gly Gly Gly Ser  Gly Gly Gly Ser Gly  Gly Gly Ser 
    1205                 1210                 1215             


Arg Asn  Leu Pro Val Ala Thr  Pro Asp Pro Gly Met  Phe Pro Cys 
    1220                 1225                 1230             


Leu His  His Ser Gln Asn Leu  Leu Arg Ala Val Ser  Asn Met Leu 
    1235                 1240                 1245             


Gln Lys  Ala Arg Gln Thr Leu  Glu Phe Tyr Pro Cys  Thr Ser Glu 
    1250                 1255                 1260             


Glu Ile  Asp His Glu Asp Ile  Thr Lys Asp Lys Thr  Ser Thr Val 
    1265                 1270                 1275             


Glu Ala  Cys Leu Pro Leu Glu  Leu Thr Lys Asn Glu  Ser Cys Leu 
    1280                 1285                 1290             


Asn Ser  Arg Glu Thr Ser Phe  Ile Thr Asn Gly Ser  Cys Leu Ala 
    1295                 1300                 1305             


Ser Arg  Lys Thr Ser Phe Met  Met Ala Leu Cys Leu  Ser Ser Ile 
    1310                 1315                 1320             


Tyr Glu  Asp Leu Lys Met Tyr  Gln Val Glu Phe Lys  Thr Met Asn 
    1325                 1330                 1335             


Ala Lys  Leu Leu Met Asp Pro  Lys Arg Gln Ile Phe  Leu Asp Gln 
    1340                 1345                 1350             


Asn Met  Leu Ala Val Ile Asp  Glu Leu Met Gln Ala  Leu Asn Phe 
    1355                 1360                 1365             


Asn Ser  Glu Thr Val Pro Gln  Lys Ser Ser Leu Glu  Glu Pro Asp 
    1370                 1375                 1380             


Phe Tyr  Lys Thr Lys Ile Lys  Leu Cys Ile Leu Leu  His Ala Phe 
    1385                 1390                 1395             


Arg Ile  Arg Ala Val Thr Ile  Asp Arg Val Met Ser  Tyr Leu Asn 
    1400                 1405                 1410             


Ala Ser  His His His His His  His His His His His  
    1415                 1420                 1425 


<210> 58
<211> 1616
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 58
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln 
            20                  25                  30          


Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly 
        35                  40                  45              


Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys 
    50                  55                  60                  


Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu 
65                  70                  75                  80  


Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser 
                85                  90                  95      


Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val 
            100                 105                 110         


Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr 
        115                 120                 125             


Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr 
    130                 135                 140                 


Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp 
                165                 170                 175     


Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln 
            180                 185                 190         


Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu 
        195                 200                 205             


Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn 
    210                 215                 220                 


Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val 
225                 230                 235                 240 


Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys 
                245                 250                 255     


Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn 
            260                 265                 270         


Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr 
        275                 280                 285             


Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu 
    290                 295                 300                 


Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe 
305                 310                 315                 320 


Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp 
                325                 330                 335     


Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly 
            340                 345                 350         


Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys 
        355                 360                 365             


Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln 
    370                 375                 380                 


Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp 
385                 390                 395                 400 


Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys 
                405                 410                 415     


Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp 
            420                 425                 430         


Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu 
        435                 440                 445             


Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp 
    450                 455                 460                 


Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys 
465                 470                 475                 480 


Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu 
                485                 490                 495     


Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu 
            500                 505                 510         


Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp 
        515                 520                 525             


Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val 
    530                 535                 540                 


Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln 
545                 550                 555                 560 


Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys 
                565                 570                 575     


Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn 
            580                 585                 590         


Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg 
        595                 600                 605             


Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys 
    610                 615                 620                 


Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys 
625                 630                 635                 640 


Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val 
                645                 650                 655     


Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe 
            660                 665                 670         


His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys 
        675                 680                 685             


Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys 
    690                 695                 700                 


Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys 
705                 710                 715                 720 


Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys 
                725                 730                 735     


Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly Gly 
            740                 745                 750         


Ser Gly Gly Gly Ser Ser Gly Gln Tyr Tyr Asp Tyr Asp Phe Pro Leu 
        755                 760                 765             


Ser Ile Tyr Gly Gln Ser Ser Pro Asn Cys Ala Pro Glu Cys Asn Cys 
    770                 775                 780                 


Pro Glu Ser Tyr Pro Ser Ala Met Tyr Cys Asp Glu Leu Lys Leu Lys 
785                 790                 795                 800 


Ser Val Pro Met Val Pro Pro Gly Ile Lys Tyr Leu Tyr Leu Arg Asn 
                805                 810                 815     


Asn Gln Ile Asp His Ile Asp Glu Lys Ala Phe Glu Asn Val Thr Asp 
            820                 825                 830         


Leu Gln Trp Leu Ile Leu Asp His Asn Leu Leu Glu Asn Ser Lys Ile 
        835                 840                 845             


Lys Gly Arg Val Phe Ser Lys Leu Lys Gln Leu Lys Lys Leu His Ile 
    850                 855                 860                 


Asn His Asn Asn Leu Thr Glu Ser Val Gly Pro Leu Pro Lys Ser Leu 
865                 870                 875                 880 


Glu Asp Leu Gln Leu Thr His Asn Lys Ile Thr Lys Leu Gly Ser Phe 
                885                 890                 895     


Glu Gly Leu Val Asn Leu Thr Phe Ile His Leu Gln His Asn Arg Leu 
            900                 905                 910         


Lys Glu Asp Ala Val Ser Ala Ala Phe Lys Gly Leu Lys Ser Leu Glu 
        915                 920                 925             


Tyr Leu Asp Leu Ser Phe Asn Gln Ile Ala Arg Leu Pro Ser Gly Leu 
    930                 935                 940                 


Pro Val Ser Leu Leu Thr Leu Tyr Leu Asp Asn Asn Lys Ile Ser Asn 
945                 950                 955                 960 


Ile Pro Asp Glu Tyr Phe Lys Arg Phe Asn Ala Leu Gln Tyr Leu Arg 
                965                 970                 975     


Leu Ser His Asn Glu Leu Ala Asp Ser Gly Ile Pro Gly Asn Ser Phe 
            980                 985                 990         


Asn Val Ser Ser Leu Val Glu Leu  Asp Leu Ser Tyr Asn  Lys Leu Lys 
        995                 1000                 1005             


Asn Ile  Pro Thr Val Asn Glu  Asn Leu Glu Asn Tyr  Tyr Leu Glu 
    1010                 1015                 1020             


Val Asn  Gln Leu Glu Lys Phe  Asp Ile Lys Ser Phe  Cys Lys Ile 
    1025                 1030                 1035             


Leu Gly  Pro Leu Ser Tyr Ser  Lys Ile Lys His Leu  Arg Leu Asp 
    1040                 1045                 1050             


Gly Asn  Arg Ile Ser Glu Thr  Ser Leu Pro Pro Asp  Met Tyr Glu 
    1055                 1060                 1065             


Cys Leu  Arg Val Ala Asn Glu  Val Thr Leu Asn Gly  Gly Gly Gly 
    1070                 1075                 1080             


Ser Gly  Gly Gly Ser Ile Trp  Glu Leu Lys Lys Asp  Val Tyr Val 
    1085                 1090                 1095             


Val Glu  Leu Asp Trp Tyr Pro  Asp Ala Pro Gly Glu  Met Val Val 
    1100                 1105                 1110             


Leu Thr  Cys Asp Thr Pro Glu  Glu Asp Gly Ile Thr  Trp Thr Leu 
    1115                 1120                 1125             


Asp Gln  Ser Ser Glu Val Leu  Gly Ser Gly Lys Thr  Leu Thr Ile 
    1130                 1135                 1140             


Gln Val  Lys Glu Phe Gly Asp  Ala Gly Gln Tyr Thr  Cys His Lys 
    1145                 1150                 1155             


Gly Gly  Glu Val Leu Ser His  Ser Leu Leu Leu Leu  His Lys Lys 
    1160                 1165                 1170             


Glu Asp  Gly Ile Trp Ser Thr  Asp Ile Leu Lys Asp  Gln Lys Glu 
    1175                 1180                 1185             


Pro Lys  Asn Lys Thr Phe Leu  Arg Cys Glu Ala Lys  Asn Tyr Ser 
    1190                 1195                 1200             


Gly Arg  Phe Thr Cys Trp Trp  Leu Thr Thr Ile Ser  Thr Asp Leu 
    1205                 1210                 1215             


Thr Phe  Ser Val Lys Ser Ser  Arg Gly Ser Ser Asp  Pro Gln Gly 
    1220                 1225                 1230             


Val Thr  Cys Gly Ala Ala Thr  Leu Ser Ala Glu Arg  Val Arg Gly 
    1235                 1240                 1245             


Asp Asn  Lys Glu Tyr Glu Tyr  Ser Val Glu Cys Gln  Glu Asp Ser 
    1250                 1255                 1260             


Ala Cys  Pro Ala Ala Glu Glu  Ser Leu Pro Ile Glu  Val Met Val 
    1265                 1270                 1275             


Asp Ala  Val His Lys Leu Lys  Tyr Glu Asn Tyr Thr  Ser Ser Phe 
    1280                 1285                 1290             


Phe Ile  Arg Asp Ile Ile Lys  Pro Asp Pro Pro Lys  Asn Leu Gln 
    1295                 1300                 1305             


Leu Lys  Pro Leu Lys Asn Ser  Arg Gln Val Glu Val  Ser Trp Glu 
    1310                 1315                 1320             


Tyr Pro  Asp Thr Trp Ser Thr  Pro His Ser Tyr Phe  Ser Leu Thr 
    1325                 1330                 1335             


Phe Cys  Val Gln Val Gln Gly  Lys Ser Lys Arg Glu  Lys Lys Asp 
    1340                 1345                 1350             


Arg Val  Phe Thr Asp Lys Thr  Ser Ala Thr Val Ile  Cys Arg Lys 
    1355                 1360                 1365             


Asn Ala  Ser Ile Ser Val Arg  Ala Gln Asp Arg Tyr  Tyr Ser Ser 
    1370                 1375                 1380             


Ser Trp  Ser Glu Trp Ala Ser  Val Pro Cys Ser Gly  Gly Ser Gly 
    1385                 1390                 1395             


Gly Gly  Ser Gly Gly Gly Ser  Gly Gly Gly Ser Arg  Asn Leu Pro 
    1400                 1405                 1410             


Val Ala  Thr Pro Asp Pro Gly  Met Phe Pro Cys Leu  His His Ser 
    1415                 1420                 1425             


Gln Asn  Leu Leu Arg Ala Val  Ser Asn Met Leu Gln  Lys Ala Arg 
    1430                 1435                 1440             


Gln Thr  Leu Glu Phe Tyr Pro  Cys Thr Ser Glu Glu  Ile Asp His 
    1445                 1450                 1455             


Glu Asp  Ile Thr Lys Asp Lys  Thr Ser Thr Val Glu  Ala Cys Leu 
    1460                 1465                 1470             


Pro Leu  Glu Leu Thr Lys Asn  Glu Ser Cys Leu Asn  Ser Arg Glu 
    1475                 1480                 1485             


Thr Ser  Phe Ile Thr Asn Gly  Ser Cys Leu Ala Ser  Arg Lys Thr 
    1490                 1495                 1500             


Ser Phe  Met Met Ala Leu Cys  Leu Ser Ser Ile Tyr  Glu Asp Leu 
    1505                 1510                 1515             


Lys Met  Tyr Gln Val Glu Phe  Lys Thr Met Asn Ala  Lys Leu Leu 
    1520                 1525                 1530             


Met Asp  Pro Lys Arg Gln Ile  Phe Leu Asp Gln Asn  Met Leu Ala 
    1535                 1540                 1545             


Val Ile  Asp Glu Leu Met Gln  Ala Leu Asn Phe Asn  Ser Glu Thr 
    1550                 1555                 1560             


Val Pro  Gln Lys Ser Ser Leu  Glu Glu Pro Asp Phe  Tyr Lys Thr 
    1565                 1570                 1575             


Lys Ile  Lys Leu Cys Ile Leu  Leu His Ala Phe Arg  Ile Arg Ala 
    1580                 1585                 1590             


Val Thr  Ile Asp Arg Val Met  Ser Tyr Leu Asn Ala  Ser His His 
    1595                 1600                 1605             


His His  His His His His His  His 
    1610                 1615     


<210> 59
<211> 968
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 59
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln 
            20                  25                  30          


Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly 
        35                  40                  45              


Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys 
    50                  55                  60                  


Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu 
65                  70                  75                  80  


Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser 
                85                  90                  95      


Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val 
            100                 105                 110         


Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr 
        115                 120                 125             


Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr 
    130                 135                 140                 


Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Ser Lys Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
                165                 170                 175     


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
            180                 185                 190         


Ser Ser Phe Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
        195                 200                 205             


Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala 
    210                 215                 220                 


Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
225                 230                 235                 240 


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
                245                 250                 255     


Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Pro Ser Ser Gln Gly Thr 
            260                 265                 270         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gln 
        275                 280                 285             


Glu Glu Asp Leu Pro Arg Pro Ser Ile Ser Ala Glu Pro Gly Thr Val 
    290                 295                 300                 


Ile Pro Leu Gly Ser His Val Thr Phe Val Cys Arg Gly Pro Val Gly 
305                 310                 315                 320 


Val Gln Thr Phe Arg Leu Glu Arg Glu Ser Arg Ser Thr Tyr Asn Asp 
                325                 330                 335     


Thr Glu Asp Val Ser Gln Ala Ser Pro Ser Glu Ser Glu Ala Arg Phe 
            340                 345                 350         


Arg Ile Asp Ser Val Ser Glu Gly Asn Ala Gly Pro Tyr Arg Cys Ile 
        355                 360                 365             


Tyr Tyr Lys Pro Pro Lys Trp Ser Glu Gln Ser Asp Tyr Leu Glu Leu 
    370                 375                 380                 


Leu Val Lys Glu Thr Ser Gly Gly Pro Asp Ser Pro Asp Thr Glu Pro 
385                 390                 395                 400 


Gly Ser Ser Ala Gly Pro Thr Gln Arg Pro Ser Asp Asn Ser His Asn 
                405                 410                 415     


Glu His Ala Pro Ala Ser Gln Gly Leu Lys Ala Glu His Leu Tyr Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Ser Ile Trp Glu Leu Lys Lys Asp Val 
        435                 440                 445             


Tyr Val Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val 
    450                 455                 460                 


Val Leu Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu 
465                 470                 475                 480 


Asp Gln Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln 
                485                 490                 495     


Val Lys Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly 
            500                 505                 510         


Glu Val Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly 
        515                 520                 525             


Ile Trp Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys 
    530                 535                 540                 


Thr Phe Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys 
545                 550                 555                 560 


Trp Trp Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser 
                565                 570                 575     


Ser Arg Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr 
            580                 585                 590         


Leu Ser Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser 
        595                 600                 605             


Val Glu Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu 
    610                 615                 620                 


Pro Ile Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn 
625                 630                 635                 640 


Tyr Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro 
                645                 650                 655     


Lys Asn Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val 
            660                 665                 670         


Ser Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser 
        675                 680                 685             


Leu Thr Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys 
    690                 695                 700                 


Asp Arg Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys 
705                 710                 715                 720 


Asn Ala Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser 
                725                 730                 735     


Trp Ser Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Ser Gly Gly Gly 
            740                 745                 750         


Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr 
        755                 760                 765             


Pro Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu 
    770                 775                 780                 


Arg Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe 
785                 790                 795                 800 


Tyr Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp 
                805                 810                 815     


Lys Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn 
            820                 825                 830         


Glu Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser 
        835                 840                 845             


Cys Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser 
    850                 855                 860                 


Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met 
865                 870                 875                 880 


Asn Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln 
                885                 890                 895     


Asn Met Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn 
            900                 905                 910         


Ser Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr 
        915                 920                 925             


Lys Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg 
    930                 935                 940                 


Ala Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser His His 
945                 950                 955                 960 


His His His His His His His His 
                965             


<210> 60
<211> 955
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 60
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln 
            20                  25                  30          


Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly 
        35                  40                  45              


Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys 
    50                  55                  60                  


Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu 
65                  70                  75                  80  


Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser 
                85                  90                  95      


Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val 
            100                 105                 110         


Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr 
        115                 120                 125             


Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr 
    130                 135                 140                 


Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Ser Lys Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
                165                 170                 175     


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
            180                 185                 190         


Ser Ser Phe Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
        195                 200                 205             


Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala 
    210                 215                 220                 


Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
225                 230                 235                 240 


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
                245                 250                 255     


Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Pro Ser Ser Gln Gly Thr 
            260                 265                 270         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gln 
        275                 280                 285             


Glu Gly Ala Leu Pro Arg Pro Ser Ile Ser Ala Glu Pro Gly Thr Val 
    290                 295                 300                 


Ile Ser Pro Gly Ser His Val Thr Phe Met Cys Arg Gly Pro Val Gly 
305                 310                 315                 320 


Val Gln Thr Phe Arg Leu Glu Arg Glu Asp Arg Ala Lys Tyr Lys Asp 
                325                 330                 335     


Ser Tyr Asn Val Phe Arg Leu Gly Pro Ser Glu Ser Glu Ala Arg Phe 
            340                 345                 350         


His Ile Asp Ser Val Ser Glu Gly Asn Ala Gly Leu Tyr Arg Cys Leu 
        355                 360                 365             


Tyr Tyr Lys Pro Pro Gly Trp Ser Glu His Ser Asp Phe Leu Glu Leu 
    370                 375                 380                 


Leu Val Lys Glu Ser Ser Gly Gly Pro Asp Ser Pro Asp Thr Glu Pro 
385                 390                 395                 400 


Gly Ser Ser Ala Gly Thr Val Pro Gly Thr Glu Ala Ser Gly Phe Asp 
                405                 410                 415     


Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Ser Ile Trp Glu Leu Lys 
            420                 425                 430         


Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly 
        435                 440                 445             


Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr 
    450                 455                 460                 


Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu 
465                 470                 475                 480 


Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His 
                485                 490                 495     


Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu Leu Leu His Lys Lys 
            500                 505                 510         


Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro 
        515                 520                 525             


Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg 
    530                 535                 540                 


Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser 
545                 550                 555                 560 


Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly 
                565                 570                 575     


Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr 
            580                 585                 590         


Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu 
        595                 600                 605             


Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala Val His Lys Leu Lys 
    610                 615                 620                 


Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro 
625                 630                 635                 640 


Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln 
                645                 650                 655     


Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser 
            660                 665                 670         


Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg 
        675                 680                 685             


Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile 
    690                 695                 700                 


Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr 
705                 710                 715                 720 


Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Ser 
                725                 730                 735     


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Asn Leu Pro 
            740                 745                 750         


Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln 
        755                 760                 765             


Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr 
    770                 775                 780                 


Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile 
785                 790                 795                 800 


Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu 
                805                 810                 815     


Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr 
            820                 825                 830         


Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu 
        835                 840                 845             


Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe 
    850                 855                 860                 


Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe 
865                 870                 875                 880 


Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu 
                885                 890                 895     


Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro 
            900                 905                 910         


Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe 
        915                 920                 925             


Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala 
    930                 935                 940                 


Ser His His His His His His His His His His 
945                 950                 955 


<210> 61
<211> 1146
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 61
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln 
            20                  25                  30          


Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly 
        35                  40                  45              


Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys 
    50                  55                  60                  


Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu 
65                  70                  75                  80  


Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser 
                85                  90                  95      


Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val 
            100                 105                 110         


Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr 
        115                 120                 125             


Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr 
    130                 135                 140                 


Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Ser Lys Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
                165                 170                 175     


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
            180                 185                 190         


Ser Ser Phe Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
        195                 200                 205             


Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala 
    210                 215                 220                 


Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
225                 230                 235                 240 


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
                245                 250                 255     


Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Pro Ser Ser Gln Gly Thr 
            260                 265                 270         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Ser 
        275                 280                 285             


Gly Gln Tyr Tyr Asp Tyr Asp Phe Pro Leu Ser Ile Tyr Gly Gln Ser 
    290                 295                 300                 


Ser Pro Asn Cys Ala Pro Glu Cys Asn Cys Pro Glu Ser Tyr Pro Ser 
305                 310                 315                 320 


Ala Met Tyr Cys Asp Glu Leu Lys Leu Lys Ser Val Pro Met Val Pro 
                325                 330                 335     


Pro Gly Ile Lys Tyr Leu Tyr Leu Arg Asn Asn Gln Ile Asp His Ile 
            340                 345                 350         


Asp Glu Lys Ala Phe Glu Asn Val Thr Asp Leu Gln Trp Leu Ile Leu 
        355                 360                 365             


Asp His Asn Leu Leu Glu Asn Ser Lys Ile Lys Gly Arg Val Phe Ser 
    370                 375                 380                 


Lys Leu Lys Gln Leu Lys Lys Leu His Ile Asn His Asn Asn Leu Thr 
385                 390                 395                 400 


Glu Ser Val Gly Pro Leu Pro Lys Ser Leu Glu Asp Leu Gln Leu Thr 
                405                 410                 415     


His Asn Lys Ile Thr Lys Leu Gly Ser Phe Glu Gly Leu Val Asn Leu 
            420                 425                 430         


Thr Phe Ile His Leu Gln His Asn Arg Leu Lys Glu Asp Ala Val Ser 
        435                 440                 445             


Ala Ala Phe Lys Gly Leu Lys Ser Leu Glu Tyr Leu Asp Leu Ser Phe 
    450                 455                 460                 


Asn Gln Ile Ala Arg Leu Pro Ser Gly Leu Pro Val Ser Leu Leu Thr 
465                 470                 475                 480 


Leu Tyr Leu Asp Asn Asn Lys Ile Ser Asn Ile Pro Asp Glu Tyr Phe 
                485                 490                 495     


Lys Arg Phe Asn Ala Leu Gln Tyr Leu Arg Leu Ser His Asn Glu Leu 
            500                 505                 510         


Ala Asp Ser Gly Ile Pro Gly Asn Ser Phe Asn Val Ser Ser Leu Val 
        515                 520                 525             


Glu Leu Asp Leu Ser Tyr Asn Lys Leu Lys Asn Ile Pro Thr Val Asn 
    530                 535                 540                 


Glu Asn Leu Glu Asn Tyr Tyr Leu Glu Val Asn Gln Leu Glu Lys Phe 
545                 550                 555                 560 


Asp Ile Lys Ser Phe Cys Lys Ile Leu Gly Pro Leu Ser Tyr Ser Lys 
                565                 570                 575     


Ile Lys His Leu Arg Leu Asp Gly Asn Arg Ile Ser Glu Thr Ser Leu 
            580                 585                 590         


Pro Pro Asp Met Tyr Glu Cys Leu Arg Val Ala Asn Glu Val Thr Leu 
        595                 600                 605             


Asn Gly Gly Gly Gly Ser Gly Gly Gly Ser Ile Trp Glu Leu Lys Lys 
    610                 615                 620                 


Asp Val Tyr Val Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu 
625                 630                 635                 640 


Met Val Val Leu Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp 
                645                 650                 655     


Thr Leu Asp Gln Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr 
            660                 665                 670         


Ile Gln Val Lys Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys 
        675                 680                 685             


Gly Gly Glu Val Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu 
    690                 695                 700                 


Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys 
705                 710                 715                 720 


Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe 
                725                 730                 735     


Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val 
            740                 745                 750         


Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala 
        755                 760                 765             


Ala Thr Leu Ser Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu 
    770                 775                 780                 


Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu 
785                 790                 795                 800 


Ser Leu Pro Ile Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr 
                805                 810                 815     


Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp 
            820                 825                 830         


Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val 
        835                 840                 845             


Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr 
    850                 855                 860                 


Phe Ser Leu Thr Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu 
865                 870                 875                 880 


Lys Lys Asp Arg Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys 
                885                 890                 895     


Arg Lys Asn Ala Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser 
            900                 905                 910         


Ser Ser Trp Ser Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Ser Gly 
        915                 920                 925             


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Asn Leu Pro Val 
    930                 935                 940                 


Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn 
945                 950                 955                 960 


Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu 
                965                 970                 975     


Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr 
            980                 985                 990         


Lys Asp Lys Thr Ser Thr Val Glu  Ala Cys Leu Pro Leu  Glu Leu Thr 
        995                 1000                 1005             


Lys Asn  Glu Ser Cys Leu Asn  Ser Arg Glu Thr Ser  Phe Ile Thr 
    1010                 1015                 1020             


Asn Gly  Ser Cys Leu Ala Ser  Arg Lys Thr Ser Phe  Met Met Ala 
    1025                 1030                 1035             


Leu Cys  Leu Ser Ser Ile Tyr  Glu Asp Leu Lys Met  Tyr Gln Val 
    1040                 1045                 1050             


Glu Phe  Lys Thr Met Asn Ala  Lys Leu Leu Met Asp  Pro Lys Arg 
    1055                 1060                 1065             


Gln Ile  Phe Leu Asp Gln Asn  Met Leu Ala Val Ile  Asp Glu Leu 
    1070                 1075                 1080             


Met Gln  Ala Leu Asn Phe Asn  Ser Glu Thr Val Pro  Gln Lys Ser 
    1085                 1090                 1095             


Ser Leu  Glu Glu Pro Asp Phe  Tyr Lys Thr Lys Ile  Lys Leu Cys 
    1100                 1105                 1110             


Ile Leu  Leu His Ala Phe Arg  Ile Arg Ala Val Thr  Ile Asp Arg 
    1115                 1120                 1125             


Val Met  Ser Tyr Leu Asn Ala  Ser His His His His  His His His 
    1130                 1135                 1140             


His His  His 
    1145     


<210> 62
<211> 1438
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 62
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val 
            20                  25                  30          


Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr 
        35                  40                  45              


Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser 
    50                  55                  60                  


Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu 
65                  70                  75                  80  


Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu 
                85                  90                  95      


Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser 
            100                 105                 110         


Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu 
        115                 120                 125             


Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu 
    130                 135                 140                 


Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly 
145                 150                 155                 160 


Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala 
                165                 170                 175     


Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys 
            180                 185                 190         


Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu 
        195                 200                 205             


Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser 
    210                 215                 220                 


Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu 
225                 230                 235                 240 


Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu 
                245                 250                 255     


Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe 
            260                 265                 270         


Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val 
        275                 280                 285             


Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser 
    290                 295                 300                 


Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu 
305                 310                 315                 320 


Trp Ala Ser Val Pro Cys Ser Gly Gly Ser Gly Gly Gly Ser Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            340                 345                 350         


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        355                 360                 365             


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    370                 375                 380                 


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
385                 390                 395                 400 


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                405                 410                 415     


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            420                 425                 430         


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        435                 440                 445             


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    450                 455                 460                 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
465                 470                 475                 480 


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                485                 490                 495     


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            500                 505                 510         


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        515                 520                 525             


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser 
    530                 535                 540                 


Gly Gly Gly Ser Gln Glu Glu Asp Leu Pro Arg Pro Ser Ile Ser Ala 
545                 550                 555                 560 


Glu Pro Gly Thr Val Ile Pro Leu Gly Ser His Val Thr Phe Val Cys 
                565                 570                 575     


Arg Gly Pro Val Gly Val Gln Thr Phe Arg Leu Glu Arg Glu Ser Arg 
            580                 585                 590         


Ser Thr Tyr Asn Asp Thr Glu Asp Val Ser Gln Ala Ser Pro Ser Glu 
        595                 600                 605             


Ser Glu Ala Arg Phe Arg Ile Asp Ser Val Ser Glu Gly Asn Ala Gly 
    610                 615                 620                 


Pro Tyr Arg Cys Ile Tyr Tyr Lys Pro Pro Lys Trp Ser Glu Gln Ser 
625                 630                 635                 640 


Asp Tyr Leu Glu Leu Leu Val Lys Glu Thr Ser Gly Gly Pro Asp Ser 
                645                 650                 655     


Pro Asp Thr Glu Pro Gly Ser Ser Ala Gly Pro Thr Gln Arg Pro Ser 
            660                 665                 670         


Asp Asn Ser His Asn Glu His Ala Pro Ala Ser Gln Gly Leu Lys Ala 
        675                 680                 685             


Glu His Leu Tyr Gly Gly Gly Gly Ser Gly Gly Gly Ser Asp Ala His 
    690                 695                 700                 


Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe 
705                 710                 715                 720 


Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro 
                725                 730                 735     


Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys 
            740                 745                 750         


Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His 
        755                 760                 765             


Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr 
    770                 775                 780                 


Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn 
785                 790                 795                 800 


Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu 
                805                 810                 815     


Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu 
            820                 825                 830         


Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro 
        835                 840                 845             


Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala 
    850                 855                 860                 


Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu 
865                 870                 875                 880 


Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys 
                885                 890                 895     


Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe 
            900                 905                 910         


Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu 
        915                 920                 925             


Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr 
    930                 935                 940                 


Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp 
945                 950                 955                 960 


Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu 
                965                 970                 975     


Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala 
            980                 985                 990         


Glu Val Glu Asn Asp Glu Met Pro  Ala Asp Leu Pro Ser  Leu Ala Ala 
        995                 1000                 1005             


Asp Phe  Val Glu Ser Lys Asp  Val Cys Lys Asn Tyr  Ala Glu Ala 
    1010                 1015                 1020             


Lys Asp  Val Phe Leu Gly Met  Phe Leu Tyr Glu Tyr  Ala Arg Arg 
    1025                 1030                 1035             


His Pro  Asp Tyr Ser Val Val  Leu Leu Leu Arg Leu  Ala Lys Thr 
    1040                 1045                 1050             


Tyr Glu  Thr Thr Leu Glu Lys  Cys Cys Ala Ala Ala  Asp Pro His 
    1055                 1060                 1065             


Glu Cys  Tyr Ala Lys Val Phe  Asp Glu Phe Lys Pro  Leu Val Glu 
    1070                 1075                 1080             


Glu Pro  Gln Asn Leu Ile Lys  Gln Asn Cys Glu Leu  Phe Glu Gln 
    1085                 1090                 1095             


Leu Gly  Glu Tyr Lys Phe Gln  Asn Ala Leu Leu Val  Arg Tyr Thr 
    1100                 1105                 1110             


Lys Lys  Val Pro Gln Val Ser  Thr Pro Thr Leu Val  Glu Val Ser 
    1115                 1120                 1125             


Arg Asn  Leu Gly Lys Val Gly  Ser Lys Cys Cys Lys  His Pro Glu 
    1130                 1135                 1140             


Ala Lys  Arg Met Pro Cys Ala  Glu Asp Tyr Leu Ser  Val Val Leu 
    1145                 1150                 1155             


Asn Gln  Leu Cys Val Leu Gln  Glu Lys Thr Pro Val  Ser Asp Arg 
    1160                 1165                 1170             


Val Thr  Lys Cys Cys Thr Glu  Ser Leu Val Asn Arg  Arg Pro Cys 
    1175                 1180                 1185             


Phe Ser  Ala Leu Glu Val Asp  Glu Thr Tyr Val Pro  Lys Glu Phe 
    1190                 1195                 1200             


Asn Ala  Glu Thr Phe Thr Phe  His Ala Asp Ile Cys  Thr Leu Ser 
    1205                 1210                 1215             


Glu Lys  Glu Arg Gln Ile Lys  Lys Gln Thr Ala Leu  Val Glu Leu 
    1220                 1225                 1230             


Val Lys  His Lys Pro Lys Ala  Thr Lys Glu Gln Leu  Lys Ala Val 
    1235                 1240                 1245             


Met Asp  Asp Phe Ala Ala Phe  Val Glu Lys Cys Cys  Lys Ala Asp 
    1250                 1255                 1260             


Asp Lys  Glu Thr Cys Phe Ala  Glu Glu Gly Lys Lys  Leu Val Ala 
    1265                 1270                 1275             


Ala Ser  Gln Ala Ala Leu Gly  Leu Gly Gly Gly Gly  Ser Gly Gly 
    1280                 1285                 1290             


Gly Ser  Ala Pro Thr Ser Ser  Ser Thr Lys Lys Thr  Gln Leu Gln 
    1295                 1300                 1305             


Leu Glu  His Leu Leu Leu Asp  Leu Gln Met Ile Leu  Asn Gly Ile 
    1310                 1315                 1320             


Asn Asn  Tyr Lys Asn Pro Lys  Leu Thr Arg Met Leu  Thr Phe Lys 
    1325                 1330                 1335             


Phe Tyr  Met Pro Lys Lys Ala  Thr Glu Leu Lys His  Leu Gln Cys 
    1340                 1345                 1350             


Leu Glu  Glu Glu Leu Lys Pro  Leu Glu Glu Val Leu  Asn Leu Ala 
    1355                 1360                 1365             


Gln Ser  Lys Asn Phe His Leu  Arg Pro Arg Asp Leu  Ile Ser Asn 
    1370                 1375                 1380             


Ile Asn  Val Ile Val Leu Glu  Leu Lys Gly Ser Glu  Thr Thr Phe 
    1385                 1390                 1395             


Met Cys  Glu Tyr Ala Asp Glu  Thr Ala Thr Ile Val  Glu Phe Leu 
    1400                 1405                 1410             


Asn Arg  Trp Ile Thr Phe Cys  Gln Ser Ile Ile Ser  Thr Leu Thr 
    1415                 1420                 1425             


His His  His His His His His  His His His 
    1430                 1435             


<210> 63
<211> 1425
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 63
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val 
            20                  25                  30          


Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr 
        35                  40                  45              


Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser 
    50                  55                  60                  


Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu 
65                  70                  75                  80  


Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu 
                85                  90                  95      


Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser 
            100                 105                 110         


Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu 
        115                 120                 125             


Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu 
    130                 135                 140                 


Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly 
145                 150                 155                 160 


Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala 
                165                 170                 175     


Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys 
            180                 185                 190         


Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu 
        195                 200                 205             


Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser 
    210                 215                 220                 


Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu 
225                 230                 235                 240 


Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu 
                245                 250                 255     


Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe 
            260                 265                 270         


Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val 
        275                 280                 285             


Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser 
    290                 295                 300                 


Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu 
305                 310                 315                 320 


Trp Ala Ser Val Pro Cys Ser Gly Gly Ser Gly Gly Gly Ser Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            340                 345                 350         


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        355                 360                 365             


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    370                 375                 380                 


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
385                 390                 395                 400 


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                405                 410                 415     


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            420                 425                 430         


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        435                 440                 445             


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    450                 455                 460                 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
465                 470                 475                 480 


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                485                 490                 495     


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            500                 505                 510         


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        515                 520                 525             


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser 
    530                 535                 540                 


Gly Gly Gly Ser Gln Glu Gly Ala Leu Pro Arg Pro Ser Ile Ser Ala 
545                 550                 555                 560 


Glu Pro Gly Thr Val Ile Ser Pro Gly Ser His Val Thr Phe Met Cys 
                565                 570                 575     


Arg Gly Pro Val Gly Val Gln Thr Phe Arg Leu Glu Arg Glu Asp Arg 
            580                 585                 590         


Ala Lys Tyr Lys Asp Ser Tyr Asn Val Phe Arg Leu Gly Pro Ser Glu 
        595                 600                 605             


Ser Glu Ala Arg Phe His Ile Asp Ser Val Ser Glu Gly Asn Ala Gly 
    610                 615                 620                 


Leu Tyr Arg Cys Leu Tyr Tyr Lys Pro Pro Gly Trp Ser Glu His Ser 
625                 630                 635                 640 


Asp Phe Leu Glu Leu Leu Val Lys Glu Ser Ser Gly Gly Pro Asp Ser 
                645                 650                 655     


Pro Asp Thr Glu Pro Gly Ser Ser Ala Gly Thr Val Pro Gly Thr Glu 
            660                 665                 670         


Ala Ser Gly Phe Asp Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Ser 
        675                 680                 685             


Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
    690                 695                 700                 


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
705                 710                 715                 720 


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
                725                 730                 735     


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
            740                 745                 750         


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
        755                 760                 765             


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
    770                 775                 780                 


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
785                 790                 795                 800 


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
                805                 810                 815     


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
            820                 825                 830         


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
        835                 840                 845             


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
    850                 855                 860                 


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
865                 870                 875                 880 


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
                885                 890                 895     


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
            900                 905                 910         


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
        915                 920                 925             


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
    930                 935                 940                 


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
945                 950                 955                 960 


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
                965                 970                 975     


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
            980                 985                 990         


Leu Ala Ala Asp Phe Val Glu Ser  Lys Asp Val Cys Lys  Asn Tyr Ala 
        995                 1000                 1005             


Glu Ala  Lys Asp Val Phe Leu  Gly Met Phe Leu Tyr  Glu Tyr Ala 
    1010                 1015                 1020             


Arg Arg  His Pro Asp Tyr Ser  Val Val Leu Leu Leu  Arg Leu Ala 
    1025                 1030                 1035             


Lys Thr  Tyr Glu Thr Thr Leu  Glu Lys Cys Cys Ala  Ala Ala Asp 
    1040                 1045                 1050             


Pro His  Glu Cys Tyr Ala Lys  Val Phe Asp Glu Phe  Lys Pro Leu 
    1055                 1060                 1065             


Val Glu  Glu Pro Gln Asn Leu  Ile Lys Gln Asn Cys  Glu Leu Phe 
    1070                 1075                 1080             


Glu Gln  Leu Gly Glu Tyr Lys  Phe Gln Asn Ala Leu  Leu Val Arg 
    1085                 1090                 1095             


Tyr Thr  Lys Lys Val Pro Gln  Val Ser Thr Pro Thr  Leu Val Glu 
    1100                 1105                 1110             


Val Ser  Arg Asn Leu Gly Lys  Val Gly Ser Lys Cys  Cys Lys His 
    1115                 1120                 1125             


Pro Glu  Ala Lys Arg Met Pro  Cys Ala Glu Asp Tyr  Leu Ser Val 
    1130                 1135                 1140             


Val Leu  Asn Gln Leu Cys Val  Leu Gln Glu Lys Thr  Pro Val Ser 
    1145                 1150                 1155             


Asp Arg  Val Thr Lys Cys Cys  Thr Glu Ser Leu Val  Asn Arg Arg 
    1160                 1165                 1170             


Pro Cys  Phe Ser Ala Leu Glu  Val Asp Glu Thr Tyr  Val Pro Lys 
    1175                 1180                 1185             


Glu Phe  Asn Ala Glu Thr Phe  Thr Phe His Ala Asp  Ile Cys Thr 
    1190                 1195                 1200             


Leu Ser  Glu Lys Glu Arg Gln  Ile Lys Lys Gln Thr  Ala Leu Val 
    1205                 1210                 1215             


Glu Leu  Val Lys His Lys Pro  Lys Ala Thr Lys Glu  Gln Leu Lys 
    1220                 1225                 1230             


Ala Val  Met Asp Asp Phe Ala  Ala Phe Val Glu Lys  Cys Cys Lys 
    1235                 1240                 1245             


Ala Asp  Asp Lys Glu Thr Cys  Phe Ala Glu Glu Gly  Lys Lys Leu 
    1250                 1255                 1260             


Val Ala  Ala Ser Gln Ala Ala  Leu Gly Leu Gly Gly  Gly Gly Ser 
    1265                 1270                 1275             


Gly Gly  Gly Ser Ala Pro Thr  Ser Ser Ser Thr Lys  Lys Thr Gln 
    1280                 1285                 1290             


Leu Gln  Leu Glu His Leu Leu  Leu Asp Leu Gln Met  Ile Leu Asn 
    1295                 1300                 1305             


Gly Ile  Asn Asn Tyr Lys Asn  Pro Lys Leu Thr Arg  Met Leu Thr 
    1310                 1315                 1320             


Phe Lys  Phe Tyr Met Pro Lys  Lys Ala Thr Glu Leu  Lys His Leu 
    1325                 1330                 1335             


Gln Cys  Leu Glu Glu Glu Leu  Lys Pro Leu Glu Glu  Val Leu Asn 
    1340                 1345                 1350             


Leu Ala  Gln Ser Lys Asn Phe  His Leu Arg Pro Arg  Asp Leu Ile 
    1355                 1360                 1365             


Ser Asn  Ile Asn Val Ile Val  Leu Glu Leu Lys Gly  Ser Glu Thr 
    1370                 1375                 1380             


Thr Phe  Met Cys Glu Tyr Ala  Asp Glu Thr Ala Thr  Ile Val Glu 
    1385                 1390                 1395             


Phe Leu  Asn Arg Trp Ile Thr  Phe Cys Gln Ser Ile  Ile Ser Thr 
    1400                 1405                 1410             


Leu Thr  His His His His His  His His His His His  
    1415                 1420                 1425 


<210> 64
<211> 1616
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 64
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val 
            20                  25                  30          


Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr 
        35                  40                  45              


Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser 
    50                  55                  60                  


Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu 
65                  70                  75                  80  


Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu 
                85                  90                  95      


Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser 
            100                 105                 110         


Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu 
        115                 120                 125             


Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu 
    130                 135                 140                 


Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly 
145                 150                 155                 160 


Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala 
                165                 170                 175     


Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys 
            180                 185                 190         


Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu 
        195                 200                 205             


Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser 
    210                 215                 220                 


Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu 
225                 230                 235                 240 


Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu 
                245                 250                 255     


Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe 
            260                 265                 270         


Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val 
        275                 280                 285             


Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser 
    290                 295                 300                 


Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu 
305                 310                 315                 320 


Trp Ala Ser Val Pro Cys Ser Gly Gly Ser Gly Gly Gly Ser Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            340                 345                 350         


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        355                 360                 365             


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    370                 375                 380                 


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
385                 390                 395                 400 


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                405                 410                 415     


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            420                 425                 430         


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        435                 440                 445             


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    450                 455                 460                 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
465                 470                 475                 480 


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                485                 490                 495     


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            500                 505                 510         


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        515                 520                 525             


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser 
    530                 535                 540                 


Gly Gly Gly Ser Ser Gly Gln Tyr Tyr Asp Tyr Asp Phe Pro Leu Ser 
545                 550                 555                 560 


Ile Tyr Gly Gln Ser Ser Pro Asn Cys Ala Pro Glu Cys Asn Cys Pro 
                565                 570                 575     


Glu Ser Tyr Pro Ser Ala Met Tyr Cys Asp Glu Leu Lys Leu Lys Ser 
            580                 585                 590         


Val Pro Met Val Pro Pro Gly Ile Lys Tyr Leu Tyr Leu Arg Asn Asn 
        595                 600                 605             


Gln Ile Asp His Ile Asp Glu Lys Ala Phe Glu Asn Val Thr Asp Leu 
    610                 615                 620                 


Gln Trp Leu Ile Leu Asp His Asn Leu Leu Glu Asn Ser Lys Ile Lys 
625                 630                 635                 640 


Gly Arg Val Phe Ser Lys Leu Lys Gln Leu Lys Lys Leu His Ile Asn 
                645                 650                 655     


His Asn Asn Leu Thr Glu Ser Val Gly Pro Leu Pro Lys Ser Leu Glu 
            660                 665                 670         


Asp Leu Gln Leu Thr His Asn Lys Ile Thr Lys Leu Gly Ser Phe Glu 
        675                 680                 685             


Gly Leu Val Asn Leu Thr Phe Ile His Leu Gln His Asn Arg Leu Lys 
    690                 695                 700                 


Glu Asp Ala Val Ser Ala Ala Phe Lys Gly Leu Lys Ser Leu Glu Tyr 
705                 710                 715                 720 


Leu Asp Leu Ser Phe Asn Gln Ile Ala Arg Leu Pro Ser Gly Leu Pro 
                725                 730                 735     


Val Ser Leu Leu Thr Leu Tyr Leu Asp Asn Asn Lys Ile Ser Asn Ile 
            740                 745                 750         


Pro Asp Glu Tyr Phe Lys Arg Phe Asn Ala Leu Gln Tyr Leu Arg Leu 
        755                 760                 765             


Ser His Asn Glu Leu Ala Asp Ser Gly Ile Pro Gly Asn Ser Phe Asn 
    770                 775                 780                 


Val Ser Ser Leu Val Glu Leu Asp Leu Ser Tyr Asn Lys Leu Lys Asn 
785                 790                 795                 800 


Ile Pro Thr Val Asn Glu Asn Leu Glu Asn Tyr Tyr Leu Glu Val Asn 
                805                 810                 815     


Gln Leu Glu Lys Phe Asp Ile Lys Ser Phe Cys Lys Ile Leu Gly Pro 
            820                 825                 830         


Leu Ser Tyr Ser Lys Ile Lys His Leu Arg Leu Asp Gly Asn Arg Ile 
        835                 840                 845             


Ser Glu Thr Ser Leu Pro Pro Asp Met Tyr Glu Cys Leu Arg Val Ala 
    850                 855                 860                 


Asn Glu Val Thr Leu Asn Gly Gly Gly Gly Ser Gly Gly Gly Ser Asp 
865                 870                 875                 880 


Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu 
                885                 890                 895     


Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln 
            900                 905                 910         


Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe 
        915                 920                 925             


Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser 
    930                 935                 940                 


Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg 
945                 950                 955                 960 


Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu 
                965                 970                 975     


Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro 
            980                 985                 990         


Arg Leu Val Arg Pro Glu Val Asp  Val Met Cys Thr Ala  Phe His Asp 
        995                 1000                 1005             


Asn Glu  Glu Thr Phe Leu Lys  Lys Tyr Leu Tyr Glu  Ile Ala Arg 
    1010                 1015                 1020             


Arg His  Pro Tyr Phe Tyr Ala  Pro Glu Leu Leu Phe  Phe Ala Lys 
    1025                 1030                 1035             


Arg Tyr  Lys Ala Ala Phe Thr  Glu Cys Cys Gln Ala  Ala Asp Lys 
    1040                 1045                 1050             


Ala Ala  Cys Leu Leu Pro Lys  Leu Asp Glu Leu Arg  Asp Glu Gly 
    1055                 1060                 1065             


Lys Ala  Ser Ser Ala Lys Gln  Arg Leu Lys Cys Ala  Ser Leu Gln 
    1070                 1075                 1080             


Lys Phe  Gly Glu Arg Ala Phe  Lys Ala Trp Ala Val  Ala Arg Leu 
    1085                 1090                 1095             


Ser Gln  Arg Phe Pro Lys Ala  Glu Phe Ala Glu Val  Ser Lys Leu 
    1100                 1105                 1110             


Val Thr  Asp Leu Thr Lys Val  His Thr Glu Cys Cys  His Gly Asp 
    1115                 1120                 1125             


Leu Leu  Glu Cys Ala Asp Asp  Arg Ala Asp Leu Ala  Lys Tyr Ile 
    1130                 1135                 1140             


Cys Glu  Asn Gln Asp Ser Ile  Ser Ser Lys Leu Lys  Glu Cys Cys 
    1145                 1150                 1155             


Glu Lys  Pro Leu Leu Glu Lys  Ser His Cys Ile Ala  Glu Val Glu 
    1160                 1165                 1170             


Asn Asp  Glu Met Pro Ala Asp  Leu Pro Ser Leu Ala  Ala Asp Phe 
    1175                 1180                 1185             


Val Glu  Ser Lys Asp Val Cys  Lys Asn Tyr Ala Glu  Ala Lys Asp 
    1190                 1195                 1200             


Val Phe  Leu Gly Met Phe Leu  Tyr Glu Tyr Ala Arg  Arg His Pro 
    1205                 1210                 1215             


Asp Tyr  Ser Val Val Leu Leu  Leu Arg Leu Ala Lys  Thr Tyr Glu 
    1220                 1225                 1230             


Thr Thr  Leu Glu Lys Cys Cys  Ala Ala Ala Asp Pro  His Glu Cys 
    1235                 1240                 1245             


Tyr Ala  Lys Val Phe Asp Glu  Phe Lys Pro Leu Val  Glu Glu Pro 
    1250                 1255                 1260             


Gln Asn  Leu Ile Lys Gln Asn  Cys Glu Leu Phe Glu  Gln Leu Gly 
    1265                 1270                 1275             


Glu Tyr  Lys Phe Gln Asn Ala  Leu Leu Val Arg Tyr  Thr Lys Lys 
    1280                 1285                 1290             


Val Pro  Gln Val Ser Thr Pro  Thr Leu Val Glu Val  Ser Arg Asn 
    1295                 1300                 1305             


Leu Gly  Lys Val Gly Ser Lys  Cys Cys Lys His Pro  Glu Ala Lys 
    1310                 1315                 1320             


Arg Met  Pro Cys Ala Glu Asp  Tyr Leu Ser Val Val  Leu Asn Gln 
    1325                 1330                 1335             


Leu Cys  Val Leu Gln Glu Lys  Thr Pro Val Ser Asp  Arg Val Thr 
    1340                 1345                 1350             


Lys Cys  Cys Thr Glu Ser Leu  Val Asn Arg Arg Pro  Cys Phe Ser 
    1355                 1360                 1365             


Ala Leu  Glu Val Asp Glu Thr  Tyr Val Pro Lys Glu  Phe Asn Ala 
    1370                 1375                 1380             


Glu Thr  Phe Thr Phe His Ala  Asp Ile Cys Thr Leu  Ser Glu Lys 
    1385                 1390                 1395             


Glu Arg  Gln Ile Lys Lys Gln  Thr Ala Leu Val Glu  Leu Val Lys 
    1400                 1405                 1410             


His Lys  Pro Lys Ala Thr Lys  Glu Gln Leu Lys Ala  Val Met Asp 
    1415                 1420                 1425             


Asp Phe  Ala Ala Phe Val Glu  Lys Cys Cys Lys Ala  Asp Asp Lys 
    1430                 1435                 1440             


Glu Thr  Cys Phe Ala Glu Glu  Gly Lys Lys Leu Val  Ala Ala Ser 
    1445                 1450                 1455             


Gln Ala  Ala Leu Gly Leu Gly  Gly Gly Gly Ser Gly  Gly Gly Ser 
    1460                 1465                 1470             


Ala Pro  Thr Ser Ser Ser Thr  Lys Lys Thr Gln Leu  Gln Leu Glu 
    1475                 1480                 1485             


His Leu  Leu Leu Asp Leu Gln  Met Ile Leu Asn Gly  Ile Asn Asn 
    1490                 1495                 1500             


Tyr Lys  Asn Pro Lys Leu Thr  Arg Met Leu Thr Phe  Lys Phe Tyr 
    1505                 1510                 1515             


Met Pro  Lys Lys Ala Thr Glu  Leu Lys His Leu Gln  Cys Leu Glu 
    1520                 1525                 1530             


Glu Glu  Leu Lys Pro Leu Glu  Glu Val Leu Asn Leu  Ala Gln Ser 
    1535                 1540                 1545             


Lys Asn  Phe His Leu Arg Pro  Arg Asp Leu Ile Ser  Asn Ile Asn 
    1550                 1555                 1560             


Val Ile  Val Leu Glu Leu Lys  Gly Ser Glu Thr Thr  Phe Met Cys 
    1565                 1570                 1575             


Glu Tyr  Ala Asp Glu Thr Ala  Thr Ile Val Glu Phe  Leu Asn Arg 
    1580                 1585                 1590             


Trp Ile  Thr Phe Cys Gln Ser  Ile Ile Ser Thr Leu  Thr His His 
    1595                 1600                 1605             


His His  His His His His His  His 
    1610                 1615     


<210> 65
<211> 1438
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 65
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln 
            20                  25                  30          


Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly 
        35                  40                  45              


Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys 
    50                  55                  60                  


Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu 
65                  70                  75                  80  


Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser 
                85                  90                  95      


Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val 
            100                 105                 110         


Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr 
        115                 120                 125             


Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr 
    130                 135                 140                 


Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Ser Gln Glu Glu Asp Leu Pro Arg Pro Ser Ile Ser Ala Glu 
                165                 170                 175     


Pro Gly Thr Val Ile Pro Leu Gly Ser His Val Thr Phe Val Cys Arg 
            180                 185                 190         


Gly Pro Val Gly Val Gln Thr Phe Arg Leu Glu Arg Glu Ser Arg Ser 
        195                 200                 205             


Thr Tyr Asn Asp Thr Glu Asp Val Ser Gln Ala Ser Pro Ser Glu Ser 
    210                 215                 220                 


Glu Ala Arg Phe Arg Ile Asp Ser Val Ser Glu Gly Asn Ala Gly Pro 
225                 230                 235                 240 


Tyr Arg Cys Ile Tyr Tyr Lys Pro Pro Lys Trp Ser Glu Gln Ser Asp 
                245                 250                 255     


Tyr Leu Glu Leu Leu Val Lys Glu Thr Ser Gly Gly Pro Asp Ser Pro 
            260                 265                 270         


Asp Thr Glu Pro Gly Ser Ser Ala Gly Pro Thr Gln Arg Pro Ser Asp 
        275                 280                 285             


Asn Ser His Asn Glu His Ala Pro Ala Ser Gln Gly Leu Lys Ala Glu 
    290                 295                 300                 


His Leu Tyr Gly Gly Gly Gly Ser Gly Gly Gly Ser Asp Ala His Lys 
305                 310                 315                 320 


Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys 
                325                 330                 335     


Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe 
            340                 345                 350         


Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr 
        355                 360                 365             


Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr 
    370                 375                 380                 


Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr 
385                 390                 395                 400 


Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu 
                405                 410                 415     


Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val 
            420                 425                 430         


Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu 
        435                 440                 445             


Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr 
    450                 455                 460                 


Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala 
465                 470                 475                 480 


Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro 
                485                 490                 495     


Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln 
            500                 505                 510         


Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys 
        515                 520                 525             


Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe 
    530                 535                 540                 


Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu 
545                 550                 555                 560 


Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu 
                565                 570                 575     


Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys 
            580                 585                 590         


Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu 
        595                 600                 605             


Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp 
    610                 615                 620                 


Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp 
625                 630                 635                 640 


Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp 
                645                 650                 655     


Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr 
            660                 665                 670         


Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys 
        675                 680                 685             


Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile 
    690                 695                 700                 


Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln 
705                 710                 715                 720 


Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr 
                725                 730                 735     


Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys 
            740                 745                 750         


Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr 
        755                 760                 765             


Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu Gln Glu Lys Thr Pro 
    770                 775                 780                 


Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg 
785                 790                 795                 800 


Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys 
                805                 810                 815     


Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu 
            820                 825                 830         


Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu 
        835                 840                 845             


Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met 
    850                 855                 860                 


Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys 
865                 870                 875                 880 


Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln 
                885                 890                 895     


Ala Ala Leu Gly Leu Gly Gly Gly Gly Ser Gly Gly Gly Ser Ile Trp 
            900                 905                 910         


Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr Pro Asp 
        915                 920                 925             


Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu Glu Asp 
    930                 935                 940                 


Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly Ser Gly 
945                 950                 955                 960 


Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly Gln Tyr 
                965                 970                 975     


Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu Leu Leu 
            980                 985                 990         


His Lys Lys Glu Asp Gly Ile Trp  Ser Thr Asp Ile Leu  Lys Asp Gln 
        995                 1000                 1005             


Lys Glu  Pro Lys Asn Lys Thr  Phe Leu Arg Cys Glu  Ala Lys Asn 
    1010                 1015                 1020             


Tyr Ser  Gly Arg Phe Thr Cys  Trp Trp Leu Thr Thr  Ile Ser Thr 
    1025                 1030                 1035             


Asp Leu  Thr Phe Ser Val Lys  Ser Ser Arg Gly Ser  Ser Asp Pro 
    1040                 1045                 1050             


Gln Gly  Val Thr Cys Gly Ala  Ala Thr Leu Ser Ala  Glu Arg Val 
    1055                 1060                 1065             


Arg Gly  Asp Asn Lys Glu Tyr  Glu Tyr Ser Val Glu  Cys Gln Glu 
    1070                 1075                 1080             


Asp Ser  Ala Cys Pro Ala Ala  Glu Glu Ser Leu Pro  Ile Glu Val 
    1085                 1090                 1095             


Met Val  Asp Ala Val His Lys  Leu Lys Tyr Glu Asn  Tyr Thr Ser 
    1100                 1105                 1110             


Ser Phe  Phe Ile Arg Asp Ile  Ile Lys Pro Asp Pro  Pro Lys Asn 
    1115                 1120                 1125             


Leu Gln  Leu Lys Pro Leu Lys  Asn Ser Arg Gln Val  Glu Val Ser 
    1130                 1135                 1140             


Trp Glu  Tyr Pro Asp Thr Trp  Ser Thr Pro His Ser  Tyr Phe Ser 
    1145                 1150                 1155             


Leu Thr  Phe Cys Val Gln Val  Gln Gly Lys Ser Lys  Arg Glu Lys 
    1160                 1165                 1170             


Lys Asp  Arg Val Phe Thr Asp  Lys Thr Ser Ala Thr  Val Ile Cys 
    1175                 1180                 1185             


Arg Lys  Asn Ala Ser Ile Ser  Val Arg Ala Gln Asp  Arg Tyr Tyr 
    1190                 1195                 1200             


Ser Ser  Ser Trp Ser Glu Trp  Ala Ser Val Pro Cys  Ser Gly Gly 
    1205                 1210                 1215             


Ser Gly  Gly Gly Ser Gly Gly  Gly Ser Gly Gly Gly  Ser Arg Asn 
    1220                 1225                 1230             


Leu Pro  Val Ala Thr Pro Asp  Pro Gly Met Phe Pro  Cys Leu His 
    1235                 1240                 1245             


His Ser  Gln Asn Leu Leu Arg  Ala Val Ser Asn Met  Leu Gln Lys 
    1250                 1255                 1260             


Ala Arg  Gln Thr Leu Glu Phe  Tyr Pro Cys Thr Ser  Glu Glu Ile 
    1265                 1270                 1275             


Asp His  Glu Asp Ile Thr Lys  Asp Lys Thr Ser Thr  Val Glu Ala 
    1280                 1285                 1290             


Cys Leu  Pro Leu Glu Leu Thr  Lys Asn Glu Ser Cys  Leu Asn Ser 
    1295                 1300                 1305             


Arg Glu  Thr Ser Phe Ile Thr  Asn Gly Ser Cys Leu  Ala Ser Arg 
    1310                 1315                 1320             


Lys Thr  Ser Phe Met Met Ala  Leu Cys Leu Ser Ser  Ile Tyr Glu 
    1325                 1330                 1335             


Asp Leu  Lys Met Tyr Gln Val  Glu Phe Lys Thr Met  Asn Ala Lys 
    1340                 1345                 1350             


Leu Leu  Met Asp Pro Lys Arg  Gln Ile Phe Leu Asp  Gln Asn Met 
    1355                 1360                 1365             


Leu Ala  Val Ile Asp Glu Leu  Met Gln Ala Leu Asn  Phe Asn Ser 
    1370                 1375                 1380             


Glu Thr  Val Pro Gln Lys Ser  Ser Leu Glu Glu Pro  Asp Phe Tyr 
    1385                 1390                 1395             


Lys Thr  Lys Ile Lys Leu Cys  Ile Leu Leu His Ala  Phe Arg Ile 
    1400                 1405                 1410             


Arg Ala  Val Thr Ile Asp Arg  Val Met Ser Tyr Leu  Asn Ala Ser 
    1415                 1420                 1425             


His His  His His His His His  His His His 
    1430                 1435             


<210> 66
<211> 1425
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 66
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln 
            20                  25                  30          


Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly 
        35                  40                  45              


Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys 
    50                  55                  60                  


Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu 
65                  70                  75                  80  


Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser 
                85                  90                  95      


Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val 
            100                 105                 110         


Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr 
        115                 120                 125             


Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr 
    130                 135                 140                 


Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Ser Gln Glu Gly Ala Leu Pro Arg Pro Ser Ile Ser Ala Glu 
                165                 170                 175     


Pro Gly Thr Val Ile Ser Pro Gly Ser His Val Thr Phe Met Cys Arg 
            180                 185                 190         


Gly Pro Val Gly Val Gln Thr Phe Arg Leu Glu Arg Glu Asp Arg Ala 
        195                 200                 205             


Lys Tyr Lys Asp Ser Tyr Asn Val Phe Arg Leu Gly Pro Ser Glu Ser 
    210                 215                 220                 


Glu Ala Arg Phe His Ile Asp Ser Val Ser Glu Gly Asn Ala Gly Leu 
225                 230                 235                 240 


Tyr Arg Cys Leu Tyr Tyr Lys Pro Pro Gly Trp Ser Glu His Ser Asp 
                245                 250                 255     


Phe Leu Glu Leu Leu Val Lys Glu Ser Ser Gly Gly Pro Asp Ser Pro 
            260                 265                 270         


Asp Thr Glu Pro Gly Ser Ser Ala Gly Thr Val Pro Gly Thr Glu Ala 
        275                 280                 285             


Ser Gly Phe Asp Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Ser Asp 
    290                 295                 300                 


Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu 
305                 310                 315                 320 


Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln 
                325                 330                 335     


Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe 
            340                 345                 350         


Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser 
        355                 360                 365             


Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg 
    370                 375                 380                 


Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu 
385                 390                 395                 400 


Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro 
                405                 410                 415     


Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp 
            420                 425                 430         


Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg 
        435                 440                 445             


His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr 
    450                 455                 460                 


Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys 
465                 470                 475                 480 


Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser 
                485                 490                 495     


Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg 
            500                 505                 510         


Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys 
        515                 520                 525             


Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val 
    530                 535                 540                 


His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg 
545                 550                 555                 560 


Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser 
                565                 570                 575     


Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys 
            580                 585                 590         


Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu 
        595                 600                 605             


Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu 
    610                 615                 620                 


Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg 
625                 630                 635                 640 


His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr 
                645                 650                 655     


Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys 
            660                 665                 670         


Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln 
        675                 680                 685             


Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr 
    690                 695                 700                 


Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln 
705                 710                 715                 720 


Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val 
                725                 730                 735     


Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala 
            740                 745                 750         


Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu Gln Glu 
        755                 760                 765             


Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu 
    770                 775                 780                 


Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr 
785                 790                 795                 800 


Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile 
                805                 810                 815     


Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu 
            820                 825                 830         


Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys 
        835                 840                 845             


Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala 
    850                 855                 860                 


Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala 
865                 870                 875                 880 


Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly Gly Ser Gly Gly Gly 
                885                 890                 895     


Ser Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp 
            900                 905                 910         


Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro 
        915                 920                 925             


Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu 
    930                 935                 940                 


Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala 
945                 950                 955                 960 


Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu 
                965                 970                 975     


Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu 
            980                 985                 990         


Lys Asp Gln Lys Glu Pro Lys Asn  Lys Thr Phe Leu Arg  Cys Glu Ala 
        995                 1000                 1005             


Lys Asn  Tyr Ser Gly Arg Phe  Thr Cys Trp Trp Leu  Thr Thr Ile 
    1010                 1015                 1020             


Ser Thr  Asp Leu Thr Phe Ser  Val Lys Ser Ser Arg  Gly Ser Ser 
    1025                 1030                 1035             


Asp Pro  Gln Gly Val Thr Cys  Gly Ala Ala Thr Leu  Ser Ala Glu 
    1040                 1045                 1050             


Arg Val  Arg Gly Asp Asn Lys  Glu Tyr Glu Tyr Ser  Val Glu Cys 
    1055                 1060                 1065             


Gln Glu  Asp Ser Ala Cys Pro  Ala Ala Glu Glu Ser  Leu Pro Ile 
    1070                 1075                 1080             


Glu Val  Met Val Asp Ala Val  His Lys Leu Lys Tyr  Glu Asn Tyr 
    1085                 1090                 1095             


Thr Ser  Ser Phe Phe Ile Arg  Asp Ile Ile Lys Pro  Asp Pro Pro 
    1100                 1105                 1110             


Lys Asn  Leu Gln Leu Lys Pro  Leu Lys Asn Ser Arg  Gln Val Glu 
    1115                 1120                 1125             


Val Ser  Trp Glu Tyr Pro Asp  Thr Trp Ser Thr Pro  His Ser Tyr 
    1130                 1135                 1140             


Phe Ser  Leu Thr Phe Cys Val  Gln Val Gln Gly Lys  Ser Lys Arg 
    1145                 1150                 1155             


Glu Lys  Lys Asp Arg Val Phe  Thr Asp Lys Thr Ser  Ala Thr Val 
    1160                 1165                 1170             


Ile Cys  Arg Lys Asn Ala Ser  Ile Ser Val Arg Ala  Gln Asp Arg 
    1175                 1180                 1185             


Tyr Tyr  Ser Ser Ser Trp Ser  Glu Trp Ala Ser Val  Pro Cys Ser 
    1190                 1195                 1200             


Gly Gly  Ser Gly Gly Gly Ser  Gly Gly Gly Ser Gly  Gly Gly Ser 
    1205                 1210                 1215             


Arg Asn  Leu Pro Val Ala Thr  Pro Asp Pro Gly Met  Phe Pro Cys 
    1220                 1225                 1230             


Leu His  His Ser Gln Asn Leu  Leu Arg Ala Val Ser  Asn Met Leu 
    1235                 1240                 1245             


Gln Lys  Ala Arg Gln Thr Leu  Glu Phe Tyr Pro Cys  Thr Ser Glu 
    1250                 1255                 1260             


Glu Ile  Asp His Glu Asp Ile  Thr Lys Asp Lys Thr  Ser Thr Val 
    1265                 1270                 1275             


Glu Ala  Cys Leu Pro Leu Glu  Leu Thr Lys Asn Glu  Ser Cys Leu 
    1280                 1285                 1290             


Asn Ser  Arg Glu Thr Ser Phe  Ile Thr Asn Gly Ser  Cys Leu Ala 
    1295                 1300                 1305             


Ser Arg  Lys Thr Ser Phe Met  Met Ala Leu Cys Leu  Ser Ser Ile 
    1310                 1315                 1320             


Tyr Glu  Asp Leu Lys Met Tyr  Gln Val Glu Phe Lys  Thr Met Asn 
    1325                 1330                 1335             


Ala Lys  Leu Leu Met Asp Pro  Lys Arg Gln Ile Phe  Leu Asp Gln 
    1340                 1345                 1350             


Asn Met  Leu Ala Val Ile Asp  Glu Leu Met Gln Ala  Leu Asn Phe 
    1355                 1360                 1365             


Asn Ser  Glu Thr Val Pro Gln  Lys Ser Ser Leu Glu  Glu Pro Asp 
    1370                 1375                 1380             


Phe Tyr  Lys Thr Lys Ile Lys  Leu Cys Ile Leu Leu  His Ala Phe 
    1385                 1390                 1395             


Arg Ile  Arg Ala Val Thr Ile  Asp Arg Val Met Ser  Tyr Leu Asn 
    1400                 1405                 1410             


Ala Ser  His His His His His  His His His His His  
    1415                 1420                 1425 


<210> 67
<211> 1616
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 67
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln 
            20                  25                  30          


Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly 
        35                  40                  45              


Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys 
    50                  55                  60                  


Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu 
65                  70                  75                  80  


Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser 
                85                  90                  95      


Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val 
            100                 105                 110         


Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr 
        115                 120                 125             


Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr 
    130                 135                 140                 


Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Ser Ser Gly Gln Tyr Tyr Asp Tyr Asp Phe Pro Leu Ser Ile 
                165                 170                 175     


Tyr Gly Gln Ser Ser Pro Asn Cys Ala Pro Glu Cys Asn Cys Pro Glu 
            180                 185                 190         


Ser Tyr Pro Ser Ala Met Tyr Cys Asp Glu Leu Lys Leu Lys Ser Val 
        195                 200                 205             


Pro Met Val Pro Pro Gly Ile Lys Tyr Leu Tyr Leu Arg Asn Asn Gln 
    210                 215                 220                 


Ile Asp His Ile Asp Glu Lys Ala Phe Glu Asn Val Thr Asp Leu Gln 
225                 230                 235                 240 


Trp Leu Ile Leu Asp His Asn Leu Leu Glu Asn Ser Lys Ile Lys Gly 
                245                 250                 255     


Arg Val Phe Ser Lys Leu Lys Gln Leu Lys Lys Leu His Ile Asn His 
            260                 265                 270         


Asn Asn Leu Thr Glu Ser Val Gly Pro Leu Pro Lys Ser Leu Glu Asp 
        275                 280                 285             


Leu Gln Leu Thr His Asn Lys Ile Thr Lys Leu Gly Ser Phe Glu Gly 
    290                 295                 300                 


Leu Val Asn Leu Thr Phe Ile His Leu Gln His Asn Arg Leu Lys Glu 
305                 310                 315                 320 


Asp Ala Val Ser Ala Ala Phe Lys Gly Leu Lys Ser Leu Glu Tyr Leu 
                325                 330                 335     


Asp Leu Ser Phe Asn Gln Ile Ala Arg Leu Pro Ser Gly Leu Pro Val 
            340                 345                 350         


Ser Leu Leu Thr Leu Tyr Leu Asp Asn Asn Lys Ile Ser Asn Ile Pro 
        355                 360                 365             


Asp Glu Tyr Phe Lys Arg Phe Asn Ala Leu Gln Tyr Leu Arg Leu Ser 
    370                 375                 380                 


His Asn Glu Leu Ala Asp Ser Gly Ile Pro Gly Asn Ser Phe Asn Val 
385                 390                 395                 400 


Ser Ser Leu Val Glu Leu Asp Leu Ser Tyr Asn Lys Leu Lys Asn Ile 
                405                 410                 415     


Pro Thr Val Asn Glu Asn Leu Glu Asn Tyr Tyr Leu Glu Val Asn Gln 
            420                 425                 430         


Leu Glu Lys Phe Asp Ile Lys Ser Phe Cys Lys Ile Leu Gly Pro Leu 
        435                 440                 445             


Ser Tyr Ser Lys Ile Lys His Leu Arg Leu Asp Gly Asn Arg Ile Ser 
    450                 455                 460                 


Glu Thr Ser Leu Pro Pro Asp Met Tyr Glu Cys Leu Arg Val Ala Asn 
465                 470                 475                 480 


Glu Val Thr Leu Asn Gly Gly Gly Gly Ser Gly Gly Gly Ser Asp Ala 
                485                 490                 495     


His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn 
            500                 505                 510         


Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys 
        515                 520                 525             


Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala 
    530                 535                 540                 


Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu 
545                 550                 555                 560 


His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu 
                565                 570                 575     


Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg 
            580                 585                 590         


Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg 
        595                 600                 605             


Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn 
    610                 615                 620                 


Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His 
625                 630                 635                 640 


Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys 
                645                 650                 655     


Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu 
            660                 665                 670         


Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala 
        675                 680                 685             


Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala 
    690                 695                 700                 


Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala 
705                 710                 715                 720 


Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His 
                725                 730                 735     


Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala 
            740                 745                 750         


Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys 
        755                 760                 765             


Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile 
    770                 775                 780                 


Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala 
785                 790                 795                 800 


Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala 
                805                 810                 815     


Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His 
            820                 825                 830         


Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu 
        835                 840                 845             


Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr 
    850                 855                 860                 


Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn 
865                 870                 875                 880 


Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys 
                885                 890                 895     


Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val 
            900                 905                 910         


Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly 
        915                 920                 925             


Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu 
    930                 935                 940                 


Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu Gln Glu Lys 
945                 950                 955                 960 


Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val 
                965                 970                 975     


Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val 
            980                 985                 990         


Pro Lys Glu Phe Asn Ala Glu Thr  Phe Thr Phe His Ala  Asp Ile Cys 
        995                 1000                 1005             


Thr Leu  Ser Glu Lys Glu Arg  Gln Ile Lys Lys Gln  Thr Ala Leu 
    1010                 1015                 1020             


Val Glu  Leu Val Lys His Lys  Pro Lys Ala Thr Lys  Glu Gln Leu 
    1025                 1030                 1035             


Lys Ala  Val Met Asp Asp Phe  Ala Ala Phe Val Glu  Lys Cys Cys 
    1040                 1045                 1050             


Lys Ala  Asp Asp Lys Glu Thr  Cys Phe Ala Glu Glu  Gly Lys Lys 
    1055                 1060                 1065             


Leu Val  Ala Ala Ser Gln Ala  Ala Leu Gly Leu Gly  Gly Gly Gly 
    1070                 1075                 1080             


Ser Gly  Gly Gly Ser Ile Trp  Glu Leu Lys Lys Asp  Val Tyr Val 
    1085                 1090                 1095             


Val Glu  Leu Asp Trp Tyr Pro  Asp Ala Pro Gly Glu  Met Val Val 
    1100                 1105                 1110             


Leu Thr  Cys Asp Thr Pro Glu  Glu Asp Gly Ile Thr  Trp Thr Leu 
    1115                 1120                 1125             


Asp Gln  Ser Ser Glu Val Leu  Gly Ser Gly Lys Thr  Leu Thr Ile 
    1130                 1135                 1140             


Gln Val  Lys Glu Phe Gly Asp  Ala Gly Gln Tyr Thr  Cys His Lys 
    1145                 1150                 1155             


Gly Gly  Glu Val Leu Ser His  Ser Leu Leu Leu Leu  His Lys Lys 
    1160                 1165                 1170             


Glu Asp  Gly Ile Trp Ser Thr  Asp Ile Leu Lys Asp  Gln Lys Glu 
    1175                 1180                 1185             


Pro Lys  Asn Lys Thr Phe Leu  Arg Cys Glu Ala Lys  Asn Tyr Ser 
    1190                 1195                 1200             


Gly Arg  Phe Thr Cys Trp Trp  Leu Thr Thr Ile Ser  Thr Asp Leu 
    1205                 1210                 1215             


Thr Phe  Ser Val Lys Ser Ser  Arg Gly Ser Ser Asp  Pro Gln Gly 
    1220                 1225                 1230             


Val Thr  Cys Gly Ala Ala Thr  Leu Ser Ala Glu Arg  Val Arg Gly 
    1235                 1240                 1245             


Asp Asn  Lys Glu Tyr Glu Tyr  Ser Val Glu Cys Gln  Glu Asp Ser 
    1250                 1255                 1260             


Ala Cys  Pro Ala Ala Glu Glu  Ser Leu Pro Ile Glu  Val Met Val 
    1265                 1270                 1275             


Asp Ala  Val His Lys Leu Lys  Tyr Glu Asn Tyr Thr  Ser Ser Phe 
    1280                 1285                 1290             


Phe Ile  Arg Asp Ile Ile Lys  Pro Asp Pro Pro Lys  Asn Leu Gln 
    1295                 1300                 1305             


Leu Lys  Pro Leu Lys Asn Ser  Arg Gln Val Glu Val  Ser Trp Glu 
    1310                 1315                 1320             


Tyr Pro  Asp Thr Trp Ser Thr  Pro His Ser Tyr Phe  Ser Leu Thr 
    1325                 1330                 1335             


Phe Cys  Val Gln Val Gln Gly  Lys Ser Lys Arg Glu  Lys Lys Asp 
    1340                 1345                 1350             


Arg Val  Phe Thr Asp Lys Thr  Ser Ala Thr Val Ile  Cys Arg Lys 
    1355                 1360                 1365             


Asn Ala  Ser Ile Ser Val Arg  Ala Gln Asp Arg Tyr  Tyr Ser Ser 
    1370                 1375                 1380             


Ser Trp  Ser Glu Trp Ala Ser  Val Pro Cys Ser Gly  Gly Ser Gly 
    1385                 1390                 1395             


Gly Gly  Ser Gly Gly Gly Ser  Gly Gly Gly Ser Arg  Asn Leu Pro 
    1400                 1405                 1410             


Val Ala  Thr Pro Asp Pro Gly  Met Phe Pro Cys Leu  His His Ser 
    1415                 1420                 1425             


Gln Asn  Leu Leu Arg Ala Val  Ser Asn Met Leu Gln  Lys Ala Arg 
    1430                 1435                 1440             


Gln Thr  Leu Glu Phe Tyr Pro  Cys Thr Ser Glu Glu  Ile Asp His 
    1445                 1450                 1455             


Glu Asp  Ile Thr Lys Asp Lys  Thr Ser Thr Val Glu  Ala Cys Leu 
    1460                 1465                 1470             


Pro Leu  Glu Leu Thr Lys Asn  Glu Ser Cys Leu Asn  Ser Arg Glu 
    1475                 1480                 1485             


Thr Ser  Phe Ile Thr Asn Gly  Ser Cys Leu Ala Ser  Arg Lys Thr 
    1490                 1495                 1500             


Ser Phe  Met Met Ala Leu Cys  Leu Ser Ser Ile Tyr  Glu Asp Leu 
    1505                 1510                 1515             


Lys Met  Tyr Gln Val Glu Phe  Lys Thr Met Asn Ala  Lys Leu Leu 
    1520                 1525                 1530             


Met Asp  Pro Lys Arg Gln Ile  Phe Leu Asp Gln Asn  Met Leu Ala 
    1535                 1540                 1545             


Val Ile  Asp Glu Leu Met Gln  Ala Leu Asn Phe Asn  Ser Glu Thr 
    1550                 1555                 1560             


Val Pro  Gln Lys Ser Ser Leu  Glu Glu Pro Asp Phe  Tyr Lys Thr 
    1565                 1570                 1575             


Lys Ile  Lys Leu Cys Ile Leu  Leu His Ala Phe Arg  Ile Arg Ala 
    1580                 1585                 1590             


Val Thr  Ile Asp Arg Val Met  Ser Tyr Leu Asn Ala  Ser His His 
    1595                 1600                 1605             


His His  His His His His His  His 
    1610                 1615     


<210> 68
<211> 1438
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 68
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln 
            20                  25                  30          


Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly 
        35                  40                  45              


Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys 
    50                  55                  60                  


Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu 
65                  70                  75                  80  


Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser 
                85                  90                  95      


Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val 
            100                 105                 110         


Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr 
        115                 120                 125             


Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr 
    130                 135                 140                 


Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp 
                165                 170                 175     


Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln 
            180                 185                 190         


Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu 
        195                 200                 205             


Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn 
    210                 215                 220                 


Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val 
225                 230                 235                 240 


Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys 
                245                 250                 255     


Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn 
            260                 265                 270         


Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr 
        275                 280                 285             


Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu 
    290                 295                 300                 


Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe 
305                 310                 315                 320 


Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp 
                325                 330                 335     


Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly 
            340                 345                 350         


Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys 
        355                 360                 365             


Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln 
    370                 375                 380                 


Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp 
385                 390                 395                 400 


Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys 
                405                 410                 415     


Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp 
            420                 425                 430         


Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu 
        435                 440                 445             


Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp 
    450                 455                 460                 


Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys 
465                 470                 475                 480 


Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu 
                485                 490                 495     


Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu 
            500                 505                 510         


Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp 
        515                 520                 525             


Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val 
    530                 535                 540                 


Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln 
545                 550                 555                 560 


Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys 
                565                 570                 575     


Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn 
            580                 585                 590         


Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg 
        595                 600                 605             


Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys 
    610                 615                 620                 


Val Leu Gln Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys 
625                 630                 635                 640 


Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val 
                645                 650                 655     


Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe 
            660                 665                 670         


His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys 
        675                 680                 685             


Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys 
    690                 695                 700                 


Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys 
705                 710                 715                 720 


Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys 
                725                 730                 735     


Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly Gly 
            740                 745                 750         


Ser Gly Gly Gly Ser Gln Glu Glu Asp Leu Pro Arg Pro Ser Ile Ser 
        755                 760                 765             


Ala Glu Pro Gly Thr Val Ile Pro Leu Gly Ser His Val Thr Phe Val 
    770                 775                 780                 


Cys Arg Gly Pro Val Gly Val Gln Thr Phe Arg Leu Glu Arg Glu Ser 
785                 790                 795                 800 


Arg Ser Thr Tyr Asn Asp Thr Glu Asp Val Ser Gln Ala Ser Pro Ser 
                805                 810                 815     


Glu Ser Glu Ala Arg Phe Arg Ile Asp Ser Val Ser Glu Gly Asn Ala 
            820                 825                 830         


Gly Pro Tyr Arg Cys Ile Tyr Tyr Lys Pro Pro Lys Trp Ser Glu Gln 
        835                 840                 845             


Ser Asp Tyr Leu Glu Leu Leu Val Lys Glu Thr Ser Gly Gly Pro Asp 
    850                 855                 860                 


Ser Pro Asp Thr Glu Pro Gly Ser Ser Ala Gly Pro Thr Gln Arg Pro 
865                 870                 875                 880 


Ser Asp Asn Ser His Asn Glu His Ala Pro Ala Ser Gln Gly Leu Lys 
                885                 890                 895     


Ala Glu His Leu Tyr Gly Gly Gly Gly Ser Gly Gly Gly Ser Ile Trp 
            900                 905                 910         


Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr Pro Asp 
        915                 920                 925             


Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu Glu Asp 
    930                 935                 940                 


Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly Ser Gly 
945                 950                 955                 960 


Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly Gln Tyr 
                965                 970                 975     


Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu Leu Leu 
            980                 985                 990         


His Lys Lys Glu Asp Gly Ile Trp  Ser Thr Asp Ile Leu  Lys Asp Gln 
        995                 1000                 1005             


Lys Glu  Pro Lys Asn Lys Thr  Phe Leu Arg Cys Glu  Ala Lys Asn 
    1010                 1015                 1020             


Tyr Ser  Gly Arg Phe Thr Cys  Trp Trp Leu Thr Thr  Ile Ser Thr 
    1025                 1030                 1035             


Asp Leu  Thr Phe Ser Val Lys  Ser Ser Arg Gly Ser  Ser Asp Pro 
    1040                 1045                 1050             


Gln Gly  Val Thr Cys Gly Ala  Ala Thr Leu Ser Ala  Glu Arg Val 
    1055                 1060                 1065             


Arg Gly  Asp Asn Lys Glu Tyr  Glu Tyr Ser Val Glu  Cys Gln Glu 
    1070                 1075                 1080             


Asp Ser  Ala Cys Pro Ala Ala  Glu Glu Ser Leu Pro  Ile Glu Val 
    1085                 1090                 1095             


Met Val  Asp Ala Val His Lys  Leu Lys Tyr Glu Asn  Tyr Thr Ser 
    1100                 1105                 1110             


Ser Phe  Phe Ile Arg Asp Ile  Ile Lys Pro Asp Pro  Pro Lys Asn 
    1115                 1120                 1125             


Leu Gln  Leu Lys Pro Leu Lys  Asn Ser Arg Gln Val  Glu Val Ser 
    1130                 1135                 1140             


Trp Glu  Tyr Pro Asp Thr Trp  Ser Thr Pro His Ser  Tyr Phe Ser 
    1145                 1150                 1155             


Leu Thr  Phe Cys Val Gln Val  Gln Gly Lys Ser Lys  Arg Glu Lys 
    1160                 1165                 1170             


Lys Asp  Arg Val Phe Thr Asp  Lys Thr Ser Ala Thr  Val Ile Cys 
    1175                 1180                 1185             


Arg Lys  Asn Ala Ser Ile Ser  Val Arg Ala Gln Asp  Arg Tyr Tyr 
    1190                 1195                 1200             


Ser Ser  Ser Trp Ser Glu Trp  Ala Ser Val Pro Cys  Ser Gly Gly 
    1205                 1210                 1215             


Ser Gly  Gly Gly Ser Gly Gly  Gly Ser Gly Gly Gly  Ser Arg Asn 
    1220                 1225                 1230             


Leu Pro  Val Ala Thr Pro Asp  Pro Gly Met Phe Pro  Cys Leu His 
    1235                 1240                 1245             


His Ser  Gln Asn Leu Leu Arg  Ala Val Ser Asn Met  Leu Gln Lys 
    1250                 1255                 1260             


Ala Arg  Gln Thr Leu Glu Phe  Tyr Pro Cys Thr Ser  Glu Glu Ile 
    1265                 1270                 1275             


Asp His  Glu Asp Ile Thr Lys  Asp Lys Thr Ser Thr  Val Glu Ala 
    1280                 1285                 1290             


Cys Leu  Pro Leu Glu Leu Thr  Lys Asn Glu Ser Cys  Leu Asn Ser 
    1295                 1300                 1305             


Arg Glu  Thr Ser Phe Ile Thr  Asn Gly Ser Cys Leu  Ala Ser Arg 
    1310                 1315                 1320             


Lys Thr  Ser Phe Met Met Ala  Leu Cys Leu Ser Ser  Ile Tyr Glu 
    1325                 1330                 1335             


Asp Leu  Lys Met Tyr Gln Val  Glu Phe Lys Thr Met  Asn Ala Lys 
    1340                 1345                 1350             


Leu Leu  Met Asp Pro Lys Arg  Gln Ile Phe Leu Asp  Gln Asn Met 
    1355                 1360                 1365             


Leu Ala  Val Ile Asp Glu Leu  Met Gln Ala Leu Asn  Phe Asn Ser 
    1370                 1375                 1380             


Glu Thr  Val Pro Gln Lys Ser  Ser Leu Glu Glu Pro  Asp Phe Tyr 
    1385                 1390                 1395             


Lys Thr  Lys Ile Lys Leu Cys  Ile Leu Leu His Ala  Phe Arg Ile 
    1400                 1405                 1410             


Arg Ala  Val Thr Ile Asp Arg  Val Met Ser Tyr Leu  Asn Ala Ser 
    1415                 1420                 1425             


His His  His His His His His  His His His 
    1430                 1435             


<210> 69
<211> 1425
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 69
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln 
            20                  25                  30          


Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly 
        35                  40                  45              


Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys 
    50                  55                  60                  


Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu 
65                  70                  75                  80  


Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser 
                85                  90                  95      


Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val 
            100                 105                 110         


Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr 
        115                 120                 125             


Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr 
    130                 135                 140                 


Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp 
                165                 170                 175     


Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln 
            180                 185                 190         


Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu 
        195                 200                 205             


Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn 
    210                 215                 220                 


Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val 
225                 230                 235                 240 


Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys 
                245                 250                 255     


Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn 
            260                 265                 270         


Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr 
        275                 280                 285             


Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu 
    290                 295                 300                 


Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe 
305                 310                 315                 320 


Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp 
                325                 330                 335     


Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly 
            340                 345                 350         


Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys 
        355                 360                 365             


Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln 
    370                 375                 380                 


Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp 
385                 390                 395                 400 


Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys 
                405                 410                 415     


Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp 
            420                 425                 430         


Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu 
        435                 440                 445             


Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp 
    450                 455                 460                 


Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys 
465                 470                 475                 480 


Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu 
                485                 490                 495     


Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu 
            500                 505                 510         


Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp 
        515                 520                 525             


Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val 
    530                 535                 540                 


Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln 
545                 550                 555                 560 


Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys 
                565                 570                 575     


Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn 
            580                 585                 590         


Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg 
        595                 600                 605             


Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys 
    610                 615                 620                 


Val Leu Gln Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys 
625                 630                 635                 640 


Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val 
                645                 650                 655     


Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe 
            660                 665                 670         


His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys 
        675                 680                 685             


Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys 
    690                 695                 700                 


Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys 
705                 710                 715                 720 


Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys 
                725                 730                 735     


Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly Gly 
            740                 745                 750         


Ser Gly Gly Gly Ser Gln Glu Gly Ala Leu Pro Arg Pro Ser Ile Ser 
        755                 760                 765             


Ala Glu Pro Gly Thr Val Ile Ser Pro Gly Ser His Val Thr Phe Met 
    770                 775                 780                 


Cys Arg Gly Pro Val Gly Val Gln Thr Phe Arg Leu Glu Arg Glu Asp 
785                 790                 795                 800 


Arg Ala Lys Tyr Lys Asp Ser Tyr Asn Val Phe Arg Leu Gly Pro Ser 
                805                 810                 815     


Glu Ser Glu Ala Arg Phe His Ile Asp Ser Val Ser Glu Gly Asn Ala 
            820                 825                 830         


Gly Leu Tyr Arg Cys Leu Tyr Tyr Lys Pro Pro Gly Trp Ser Glu His 
        835                 840                 845             


Ser Asp Phe Leu Glu Leu Leu Val Lys Glu Ser Ser Gly Gly Pro Asp 
    850                 855                 860                 


Ser Pro Asp Thr Glu Pro Gly Ser Ser Ala Gly Thr Val Pro Gly Thr 
865                 870                 875                 880 


Glu Ala Ser Gly Phe Asp Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly 
                885                 890                 895     


Ser Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp 
            900                 905                 910         


Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro 
        915                 920                 925             


Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu 
    930                 935                 940                 


Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala 
945                 950                 955                 960 


Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu 
                965                 970                 975     


Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu 
            980                 985                 990         


Lys Asp Gln Lys Glu Pro Lys Asn  Lys Thr Phe Leu Arg  Cys Glu Ala 
        995                 1000                 1005             


Lys Asn  Tyr Ser Gly Arg Phe  Thr Cys Trp Trp Leu  Thr Thr Ile 
    1010                 1015                 1020             


Ser Thr  Asp Leu Thr Phe Ser  Val Lys Ser Ser Arg  Gly Ser Ser 
    1025                 1030                 1035             


Asp Pro  Gln Gly Val Thr Cys  Gly Ala Ala Thr Leu  Ser Ala Glu 
    1040                 1045                 1050             


Arg Val  Arg Gly Asp Asn Lys  Glu Tyr Glu Tyr Ser  Val Glu Cys 
    1055                 1060                 1065             


Gln Glu  Asp Ser Ala Cys Pro  Ala Ala Glu Glu Ser  Leu Pro Ile 
    1070                 1075                 1080             


Glu Val  Met Val Asp Ala Val  His Lys Leu Lys Tyr  Glu Asn Tyr 
    1085                 1090                 1095             


Thr Ser  Ser Phe Phe Ile Arg  Asp Ile Ile Lys Pro  Asp Pro Pro 
    1100                 1105                 1110             


Lys Asn  Leu Gln Leu Lys Pro  Leu Lys Asn Ser Arg  Gln Val Glu 
    1115                 1120                 1125             


Val Ser  Trp Glu Tyr Pro Asp  Thr Trp Ser Thr Pro  His Ser Tyr 
    1130                 1135                 1140             


Phe Ser  Leu Thr Phe Cys Val  Gln Val Gln Gly Lys  Ser Lys Arg 
    1145                 1150                 1155             


Glu Lys  Lys Asp Arg Val Phe  Thr Asp Lys Thr Ser  Ala Thr Val 
    1160                 1165                 1170             


Ile Cys  Arg Lys Asn Ala Ser  Ile Ser Val Arg Ala  Gln Asp Arg 
    1175                 1180                 1185             


Tyr Tyr  Ser Ser Ser Trp Ser  Glu Trp Ala Ser Val  Pro Cys Ser 
    1190                 1195                 1200             


Gly Gly  Ser Gly Gly Gly Ser  Gly Gly Gly Ser Gly  Gly Gly Ser 
    1205                 1210                 1215             


Arg Asn  Leu Pro Val Ala Thr  Pro Asp Pro Gly Met  Phe Pro Cys 
    1220                 1225                 1230             


Leu His  His Ser Gln Asn Leu  Leu Arg Ala Val Ser  Asn Met Leu 
    1235                 1240                 1245             


Gln Lys  Ala Arg Gln Thr Leu  Glu Phe Tyr Pro Cys  Thr Ser Glu 
    1250                 1255                 1260             


Glu Ile  Asp His Glu Asp Ile  Thr Lys Asp Lys Thr  Ser Thr Val 
    1265                 1270                 1275             


Glu Ala  Cys Leu Pro Leu Glu  Leu Thr Lys Asn Glu  Ser Cys Leu 
    1280                 1285                 1290             


Asn Ser  Arg Glu Thr Ser Phe  Ile Thr Asn Gly Ser  Cys Leu Ala 
    1295                 1300                 1305             


Ser Arg  Lys Thr Ser Phe Met  Met Ala Leu Cys Leu  Ser Ser Ile 
    1310                 1315                 1320             


Tyr Glu  Asp Leu Lys Met Tyr  Gln Val Glu Phe Lys  Thr Met Asn 
    1325                 1330                 1335             


Ala Lys  Leu Leu Met Asp Pro  Lys Arg Gln Ile Phe  Leu Asp Gln 
    1340                 1345                 1350             


Asn Met  Leu Ala Val Ile Asp  Glu Leu Met Gln Ala  Leu Asn Phe 
    1355                 1360                 1365             


Asn Ser  Glu Thr Val Pro Gln  Lys Ser Ser Leu Glu  Glu Pro Asp 
    1370                 1375                 1380             


Phe Tyr  Lys Thr Lys Ile Lys  Leu Cys Ile Leu Leu  His Ala Phe 
    1385                 1390                 1395             


Arg Ile  Arg Ala Val Thr Ile  Asp Arg Val Met Ser  Tyr Leu Asn 
    1400                 1405                 1410             


Ala Ser  His His His His His  His His His His His  
    1415                 1420                 1425 


<210> 70
<211> 1616
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 70
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln 
            20                  25                  30          


Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly 
        35                  40                  45              


Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys 
    50                  55                  60                  


Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu 
65                  70                  75                  80  


Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser 
                85                  90                  95      


Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val 
            100                 105                 110         


Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr 
        115                 120                 125             


Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr 
    130                 135                 140                 


Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp 
                165                 170                 175     


Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln 
            180                 185                 190         


Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu 
        195                 200                 205             


Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn 
    210                 215                 220                 


Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val 
225                 230                 235                 240 


Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys 
                245                 250                 255     


Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn 
            260                 265                 270         


Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr 
        275                 280                 285             


Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu 
    290                 295                 300                 


Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe 
305                 310                 315                 320 


Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp 
                325                 330                 335     


Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly 
            340                 345                 350         


Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys 
        355                 360                 365             


Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln 
    370                 375                 380                 


Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp 
385                 390                 395                 400 


Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys 
                405                 410                 415     


Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp 
            420                 425                 430         


Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu 
        435                 440                 445             


Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp 
    450                 455                 460                 


Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys 
465                 470                 475                 480 


Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu 
                485                 490                 495     


Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu 
            500                 505                 510         


Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp 
        515                 520                 525             


Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val 
    530                 535                 540                 


Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln 
545                 550                 555                 560 


Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys 
                565                 570                 575     


Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn 
            580                 585                 590         


Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg 
        595                 600                 605             


Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys 
    610                 615                 620                 


Val Leu Gln Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys 
625                 630                 635                 640 


Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val 
                645                 650                 655     


Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe 
            660                 665                 670         


His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys 
        675                 680                 685             


Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys 
    690                 695                 700                 


Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys 
705                 710                 715                 720 


Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys 
                725                 730                 735     


Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly Gly 
            740                 745                 750         


Ser Gly Gly Gly Ser Ser Gly Gln Tyr Tyr Asp Tyr Asp Phe Pro Leu 
        755                 760                 765             


Ser Ile Tyr Gly Gln Ser Ser Pro Asn Cys Ala Pro Glu Cys Asn Cys 
    770                 775                 780                 


Pro Glu Ser Tyr Pro Ser Ala Met Tyr Cys Asp Glu Leu Lys Leu Lys 
785                 790                 795                 800 


Ser Val Pro Met Val Pro Pro Gly Ile Lys Tyr Leu Tyr Leu Arg Asn 
                805                 810                 815     


Asn Gln Ile Asp His Ile Asp Glu Lys Ala Phe Glu Asn Val Thr Asp 
            820                 825                 830         


Leu Gln Trp Leu Ile Leu Asp His Asn Leu Leu Glu Asn Ser Lys Ile 
        835                 840                 845             


Lys Gly Arg Val Phe Ser Lys Leu Lys Gln Leu Lys Lys Leu His Ile 
    850                 855                 860                 


Asn His Asn Asn Leu Thr Glu Ser Val Gly Pro Leu Pro Lys Ser Leu 
865                 870                 875                 880 


Glu Asp Leu Gln Leu Thr His Asn Lys Ile Thr Lys Leu Gly Ser Phe 
                885                 890                 895     


Glu Gly Leu Val Asn Leu Thr Phe Ile His Leu Gln His Asn Arg Leu 
            900                 905                 910         


Lys Glu Asp Ala Val Ser Ala Ala Phe Lys Gly Leu Lys Ser Leu Glu 
        915                 920                 925             


Tyr Leu Asp Leu Ser Phe Asn Gln Ile Ala Arg Leu Pro Ser Gly Leu 
    930                 935                 940                 


Pro Val Ser Leu Leu Thr Leu Tyr Leu Asp Asn Asn Lys Ile Ser Asn 
945                 950                 955                 960 


Ile Pro Asp Glu Tyr Phe Lys Arg Phe Asn Ala Leu Gln Tyr Leu Arg 
                965                 970                 975     


Leu Ser His Asn Glu Leu Ala Asp Ser Gly Ile Pro Gly Asn Ser Phe 
            980                 985                 990         


Asn Val Ser Ser Leu Val Glu Leu  Asp Leu Ser Tyr Asn  Lys Leu Lys 
        995                 1000                 1005             


Asn Ile  Pro Thr Val Asn Glu  Asn Leu Glu Asn Tyr  Tyr Leu Glu 
    1010                 1015                 1020             


Val Asn  Gln Leu Glu Lys Phe  Asp Ile Lys Ser Phe  Cys Lys Ile 
    1025                 1030                 1035             


Leu Gly  Pro Leu Ser Tyr Ser  Lys Ile Lys His Leu  Arg Leu Asp 
    1040                 1045                 1050             


Gly Asn  Arg Ile Ser Glu Thr  Ser Leu Pro Pro Asp  Met Tyr Glu 
    1055                 1060                 1065             


Cys Leu  Arg Val Ala Asn Glu  Val Thr Leu Asn Gly  Gly Gly Gly 
    1070                 1075                 1080             


Ser Gly  Gly Gly Ser Ile Trp  Glu Leu Lys Lys Asp  Val Tyr Val 
    1085                 1090                 1095             


Val Glu  Leu Asp Trp Tyr Pro  Asp Ala Pro Gly Glu  Met Val Val 
    1100                 1105                 1110             


Leu Thr  Cys Asp Thr Pro Glu  Glu Asp Gly Ile Thr  Trp Thr Leu 
    1115                 1120                 1125             


Asp Gln  Ser Ser Glu Val Leu  Gly Ser Gly Lys Thr  Leu Thr Ile 
    1130                 1135                 1140             


Gln Val  Lys Glu Phe Gly Asp  Ala Gly Gln Tyr Thr  Cys His Lys 
    1145                 1150                 1155             


Gly Gly  Glu Val Leu Ser His  Ser Leu Leu Leu Leu  His Lys Lys 
    1160                 1165                 1170             


Glu Asp  Gly Ile Trp Ser Thr  Asp Ile Leu Lys Asp  Gln Lys Glu 
    1175                 1180                 1185             


Pro Lys  Asn Lys Thr Phe Leu  Arg Cys Glu Ala Lys  Asn Tyr Ser 
    1190                 1195                 1200             


Gly Arg  Phe Thr Cys Trp Trp  Leu Thr Thr Ile Ser  Thr Asp Leu 
    1205                 1210                 1215             


Thr Phe  Ser Val Lys Ser Ser  Arg Gly Ser Ser Asp  Pro Gln Gly 
    1220                 1225                 1230             


Val Thr  Cys Gly Ala Ala Thr  Leu Ser Ala Glu Arg  Val Arg Gly 
    1235                 1240                 1245             


Asp Asn  Lys Glu Tyr Glu Tyr  Ser Val Glu Cys Gln  Glu Asp Ser 
    1250                 1255                 1260             


Ala Cys  Pro Ala Ala Glu Glu  Ser Leu Pro Ile Glu  Val Met Val 
    1265                 1270                 1275             


Asp Ala  Val His Lys Leu Lys  Tyr Glu Asn Tyr Thr  Ser Ser Phe 
    1280                 1285                 1290             


Phe Ile  Arg Asp Ile Ile Lys  Pro Asp Pro Pro Lys  Asn Leu Gln 
    1295                 1300                 1305             


Leu Lys  Pro Leu Lys Asn Ser  Arg Gln Val Glu Val  Ser Trp Glu 
    1310                 1315                 1320             


Tyr Pro  Asp Thr Trp Ser Thr  Pro His Ser Tyr Phe  Ser Leu Thr 
    1325                 1330                 1335             


Phe Cys  Val Gln Val Gln Gly  Lys Ser Lys Arg Glu  Lys Lys Asp 
    1340                 1345                 1350             


Arg Val  Phe Thr Asp Lys Thr  Ser Ala Thr Val Ile  Cys Arg Lys 
    1355                 1360                 1365             


Asn Ala  Ser Ile Ser Val Arg  Ala Gln Asp Arg Tyr  Tyr Ser Ser 
    1370                 1375                 1380             


Ser Trp  Ser Glu Trp Ala Ser  Val Pro Cys Ser Gly  Gly Ser Gly 
    1385                 1390                 1395             


Gly Gly  Ser Gly Gly Gly Ser  Gly Gly Gly Ser Arg  Asn Leu Pro 
    1400                 1405                 1410             


Val Ala  Thr Pro Asp Pro Gly  Met Phe Pro Cys Leu  His His Ser 
    1415                 1420                 1425             


Gln Asn  Leu Leu Arg Ala Val  Ser Asn Met Leu Gln  Lys Ala Arg 
    1430                 1435                 1440             


Gln Thr  Leu Glu Phe Tyr Pro  Cys Thr Ser Glu Glu  Ile Asp His 
    1445                 1450                 1455             


Glu Asp  Ile Thr Lys Asp Lys  Thr Ser Thr Val Glu  Ala Cys Leu 
    1460                 1465                 1470             


Pro Leu  Glu Leu Thr Lys Asn  Glu Ser Cys Leu Asn  Ser Arg Glu 
    1475                 1480                 1485             


Thr Ser  Phe Ile Thr Asn Gly  Ser Cys Leu Ala Ser  Arg Lys Thr 
    1490                 1495                 1500             


Ser Phe  Met Met Ala Leu Cys  Leu Ser Ser Ile Tyr  Glu Asp Leu 
    1505                 1510                 1515             


Lys Met  Tyr Gln Val Glu Phe  Lys Thr Met Asn Ala  Lys Leu Leu 
    1520                 1525                 1530             


Met Asp  Pro Lys Arg Gln Ile  Phe Leu Asp Gln Asn  Met Leu Ala 
    1535                 1540                 1545             


Val Ile  Asp Glu Leu Met Gln  Ala Leu Asn Phe Asn  Ser Glu Thr 
    1550                 1555                 1560             


Val Pro  Gln Lys Ser Ser Leu  Glu Glu Pro Asp Phe  Tyr Lys Thr 
    1565                 1570                 1575             


Lys Ile  Lys Leu Cys Ile Leu  Leu His Ala Phe Arg  Ile Arg Ala 
    1580                 1585                 1590             


Val Thr  Ile Asp Arg Val Met  Ser Tyr Leu Asn Ala  Ser His His 
    1595                 1600                 1605             


His His  His His His His His  His 
    1610                 1615     


<210> 71
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 71
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala 
            20      


<210> 72
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      10xHis tag

<400> 72
His His His His His His His His His His 
1               5                   10  


<210> 73
<211> 50
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> SITE
<222> (1)..(50)
<223> This sequence may encompass 1-10 "Gly Gly Gly Gly Ser"
      repeating units

<220>
<223> See specification for detailed description of substitutions
      and preferred embodiments

<400> 73
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser 
    50  


<210> 74
<211> 50
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<221> SITE
<222> (1)..(50)
<223> This sequence may encompass 1-10 "Ser Gly Gly Gly Gly"
      repeating units

<220>
<223> See specification for detailed description of substitutions
      and preferred embodiments

<400> 74
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        35                  40                  45              


Gly Gly 
    50  


<210> 75
<211> 54
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> SITE
<222> (5)..(54)
<223> This sequence may encompass 1-10 "Ser Gly Gly Gly Gly"
      repeating units

<220>
<223> See specification for detailed description of substitutions
      and preferred embodiments

<400> 75
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly 
    50                  


<210> 76
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> See specification for detailed description of substitutions
      and preferred embodiments

<400> 76
Ser Gly Gly Gly Gly Ser 
1               5       


<210> 77
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> See specification for detailed description of substitutions
      and preferred embodiments

<400> 77
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser 
            20      


<210> 78
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> See specification for detailed description of substitutions
      and preferred embodiments

<400> 78
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210> 79
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> See specification for detailed description of substitutions
      and preferred embodiments

<400> 79
Gly Gly Gly Gly Ser 
1               5   


<210> 80
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> See specification for detailed description of substitutions
      and preferred embodiments

<400> 80
Gly Gly Gly Ser 
1               

