                         SEQUENCE LISTING

<110>  KINDRED BIOSCIENCES, INC.
 
<120>  TNF ALPHA AND NGF ANTIBODIES FOR VETERINARY USE

<130>  01157-0035-00PCT

<140>  PCT/US2021/064223
<141>  2021-12-17

<150>  US 63/127,994
<151>  2020-12-18

<150>  US 63/128,804
<151>  2020-12-21

<160>  83    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain CDR L1 of D2E7

<400>  1

Arg Ala Ser Gln Gly Ile Arg Asn Tyr Leu Ala 
1               5                   10      


<210>  2
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain CDR L2 of D2E7

<400>  2

Ala Ala Ser Thr Leu Gln 
1               5       


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain CDR L3 of D2E7

<400>  3

Gln Arg Tyr Asn Arg Ala Pro Tyr Thr 
1               5                   


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain CDR H1 of D2E7

<400>  4

Phe Thr Phe Asp Asp Tyr Ala Met His 
1               5                   


<210>  5
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain CDR H2 of D2E7

<400>  5

Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val Glu 
1               5                   10                  15      


Gly Arg 
        


<210>  6
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain CDR H3 of D2E7

<400>  6

Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr 
1               5                   10                  


<210>  7
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain of D2E7

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  8
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain of D2E7

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  9
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric variable light chain of D2E7 and canine kappa light 
       constant region with leader

<400>  9

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn 
            100                 105                 110         


Arg Ala Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln 
    130                 135                 140                 


Leu His Thr Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr 
145                 150                 155                 160 


Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp 
                165                 170                 175     


Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His 
        195                 200                 205             


Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu 
    210                 215                 220                 


Ile Lys Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
225                 230                 235         


<210>  10
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric variable light chain of D2E7 and canine kappa light 
       constant region

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Asn Asp Ala Gln 
            100                 105                 110         


Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly 
        115                 120                 125             


Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser 
            180                 185                 190         


Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe 
        195                 200                 205             


Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215         


<210>  11
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric variable heavy chain of D2E7 and canine IgG-B constant 
       region with leader

<400>  11

Met Ala Val Leu Gly Leu Leu Leu Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Asp Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr 
    130                 135                 140                 


Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly 
145                 150                 155                 160 


Ser Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met 
        195                 200                 205             


Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn 
    210                 215                 220                 


Val Ala His Pro Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys 
225                 230                 235                 240 


Arg Glu Asn Gly Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro 
                245                 250                 255     


Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe 
    290                 295                 300                 


Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His 
                325                 330                 335     


Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys 
            340                 345                 350         


Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln 
        355                 360                 365             


Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu 
    370                 375                 380                 


Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro 
385                 390                 395                 400 


Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu 
                405                 410                 415     


Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly 
        435                 440                 445             


Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
465                 470                 475 


<210>  12
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric variable heavy chain of D2E7 and canine IgG-B constant 
       region

<400>  12

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val 
    130                 135                 140                 


Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val 
            180                 185                 190         


Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His 
        195                 200                 205             


Pro Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn 
    210                 215                 220                 


Gly Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly 
        275                 280                 285             


Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn 
    290                 295                 300                 


Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp 
305                 310                 315                 320 


Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro 
                325                 330                 335     


Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln 
            340                 345                 350         


Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn 
        355                 360                 365             


Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile 
    370                 375                 380                 


Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr 
385                 390                 395                 400 


Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe 
            420                 425                 430         


Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu 
        435                 440                 445             


Ser Leu Ser His Ser Pro Gly Lys 
    450                 455     


<210>  13
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized variable light chain of D2E7 v1 and  canine kappa light
       constant region with leader

<400>  13

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Val Met Thr Gln Thr Pro Leu Ser 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Pro Val Ser Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Gly Ile Arg Asn Tyr Leu Ala Trp Tyr Leu Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ser Pro Arg Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg 
                85                  90                  95      


Ile Gly Arg Leu Glu Ala Glu Asp Ala Ala Ile Tyr Tyr Cys Gln Arg 
            100                 105                 110         


Tyr Asn Arg Ala Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro 
    130                 135                 140                 


Asp Gln Leu His Thr Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser 
145                 150                 155                 160 


Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile 
                165                 170                 175     


Gln Asp Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu 
        195                 200                 205             


Ser His Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser 
    210                 215                 220                 


Thr Leu Ile Lys Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
225                 230                 235                 


<210>  14
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized variable light chain of D2E7 v1 (KBA VL v1)

<400>  14

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Pro Val Ser Ile Ser Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Gly Arg Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Ile Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  15
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized variable light chain of D2E7 v1 and  canine kappa light
       constant region

<400>  15

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Pro Val Ser Ile Ser Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Gly Arg Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Ile Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Asn Asp Ala Gln 
            100                 105                 110         


Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly 
        115                 120                 125             


Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser 
            180                 185                 190         


Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe 
        195                 200                 205             


Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215         


<210>  16
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain framework region LC-FR2 of KBA VL v1

<400>  16

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  17
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized variable light chain of D2E7 v2 and  canine kappa light
       constant region with leader

<400>  17

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Val Met Thr Gln Thr Pro Pro Ser 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Pro Val Ser Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Gly Ile Arg Asn Tyr Leu Ala Trp Phe Arg Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ser Pro Gln Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg 
                85                  90                  95      


Ile Ser Arg Leu Glu Ala Asp Asp Ala Ala Val Tyr Tyr Cys Gln Arg 
            100                 105                 110         


Tyr Asn Arg Ala Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro 
    130                 135                 140                 


Asp Gln Leu His Thr Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser 
145                 150                 155                 160 


Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile 
                165                 170                 175     


Gln Asp Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu 
        195                 200                 205             


Ser His Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser 
    210                 215                 220                 


Thr Leu Ile Lys Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
225                 230                 235                 


<210>  18
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized variable light chain of D2E7 v2 (KBA VL v2)

<400>  18

Asp Ile Val Met Thr Gln Thr Pro Pro Ser Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Pro Val Ser Ile Ser Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Arg Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Ser Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser Arg Leu Glu Ala 
65                  70                  75                  80  


Asp Asp Ala Ala Val Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  19
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized variable light chain of D2E7 v2 and  canine kappa light
       constant region

<400>  19

Asp Ile Val Met Thr Gln Thr Pro Pro Ser Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Pro Val Ser Ile Ser Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Arg Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Ser Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser Arg Leu Glu Ala 
65                  70                  75                  80  


Asp Asp Ala Ala Val Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Asn Asp Ala Gln 
            100                 105                 110         


Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly 
        115                 120                 125             


Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser 
            180                 185                 190         


Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe 
        195                 200                 205             


Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215         


<210>  20
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain framework region LC-FR2 of KBA VL v2

<400>  20

Trp Phe Arg Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  21
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary caninized variable heavy chain of D2E7 and canine IgG-B
       constant region with leader

<400>  21

Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Asp Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Gln Trp Val Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala 
65                  70                  75                  80  


Asp Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr 
    130                 135                 140                 


Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly 
145                 150                 155                 160 


Ser Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met 
        195                 200                 205             


Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn 
    210                 215                 220                 


Val Ala His Pro Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys 
225                 230                 235                 240 


Arg Glu Asn Gly Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro 
                245                 250                 255     


Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe 
    290                 295                 300                 


Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His 
                325                 330                 335     


Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys 
            340                 345                 350         


Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln 
        355                 360                 365             


Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu 
    370                 375                 380                 


Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro 
385                 390                 395                 400 


Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu 
                405                 410                 415     


Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly 
        435                 440                 445             


Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
465                 470                 475 


<210>  22
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary caninized variable heavy chain of D2E7 (KBA VH)

<400>  22

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  23
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary caninized variable heavy chain of D2E7 and canine IgG-B
       constant region

<400>  23

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val 
    130                 135                 140                 


Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val 
            180                 185                 190         


Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His 
        195                 200                 205             


Pro Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn 
    210                 215                 220                 


Gly Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly 
        275                 280                 285             


Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn 
    290                 295                 300                 


Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp 
305                 310                 315                 320 


Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro 
                325                 330                 335     


Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln 
            340                 345                 350         


Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn 
        355                 360                 365             


Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile 
    370                 375                 380                 


Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr 
385                 390                 395                 400 


Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe 
            420                 425                 430         


Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu 
        435                 440                 445             


Ser Leu Ser His Ser Pro Gly Lys 
    450                 455     


<210>  24
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized variable light chain of D2E7 v3 and canine kappa light 
       constant region with leader

<400>  24

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ser Gly Ala Arg Cys Asp Ile Val Met Thr Gln Thr Pro Leu Ser 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Pro Val Ser Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Gly Ile Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Arg Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg 
                85                  90                  95      


Ile Gly Arg Leu Glu Ala Glu Asp Ala Ala Ile Tyr Tyr Cys Gln Arg 
            100                 105                 110         


Tyr Asn Arg Ala Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro 
    130                 135                 140                 


Asp Gln Leu His Thr Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser 
145                 150                 155                 160 


Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile 
                165                 170                 175     


Gln Asp Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu 
        195                 200                 205             


Ser His Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser 
    210                 215                 220                 


Thr Leu Ile Lys Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
225                 230                 235                 


<210>  25
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized variable light chain of D2E7 v3 (KBA VL v3)

<400>  25

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Pro Val Ser Ile Ser Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Gly Arg Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Ile Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  26
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized variable light chain of D2E7 v3 and canine kappa light 
       constant region

<400>  26

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Pro Val Ser Ile Ser Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Gly Arg Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Ile Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Asn Asp Ala Gln 
            100                 105                 110         


Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly 
        115                 120                 125             


Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser 
            180                 185                 190         


Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe 
        195                 200                 205             


Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215         


<210>  27
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain framework region LC-FR2 of KBA VL v3

<400>  27

Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  28
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized variable light chain of D2E7 v4 and canine kappa light 
       constant region with leader

<400>  28

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ser Gly Ala Arg Cys Asp Ile Val Met Thr Gln Ser Pro Ala Ser 
            20                  25                  30          


Leu Ser Leu Ser Gln Glu Glu Lys Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Gly Ile Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Phe Thr 
                85                  90                  95      


Ile Ser Ser Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Arg 
            100                 105                 110         


Tyr Asn Arg Ala Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro 
    130                 135                 140                 


Asp Gln Leu His Thr Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser 
145                 150                 155                 160 


Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile 
                165                 170                 175     


Gln Asp Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu 
        195                 200                 205             


Ser His Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser 
    210                 215                 220                 


Thr Leu Ile Lys Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
225                 230                 235                 


<210>  29
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized variable light chain of D2E7 v4 (KBA VL v4)

<400>  29

Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Leu Ser Gln Glu 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Phe Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  30
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized variable light chain of D2E7 v4 and canine kappa light 
       constant region

<400>  30

Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Leu Ser Gln Glu 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Phe Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Asn Asp Ala Gln 
            100                 105                 110         


Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly 
        115                 120                 125             


Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser 
            180                 185                 190         


Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe 
        195                 200                 205             


Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215         


<210>  31
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain framework region LC-FR2 of KBA VL v4

<400>  31

Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  32
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized variable light chain of D2E7 v5 and  canine kappa light
       constant region with leader

<400>  32

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ser Gly Ala Arg Cys Glu Ile Gln Met Thr Gln Ser Pro Thr Leu 
            20                  25                  30          


Leu Ser Val Ser Pro Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
        35                  40                  45              


Gln Gly Ile Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Arg Gly Asn 
    50                  55                  60                  


Ala Pro Lys Cys Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Leu Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Asn Ser Leu Glu Pro Lys Asp Val Ala Thr Tyr Tyr Cys Gln Arg 
            100                 105                 110         


Tyr Asn Arg Ala Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro 
    130                 135                 140                 


Asp Gln Leu His Thr Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser 
145                 150                 155                 160 


Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile 
                165                 170                 175     


Gln Asp Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu 
        195                 200                 205             


Ser His Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser 
    210                 215                 220                 


Thr Leu Ile Lys Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
225                 230                 235                 


<210>  33
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized variable light chain of D2E7 v5 (KBA VL v5)

<400>  33

Glu Ile Gln Met Thr Gln Ser Pro Thr Leu Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Arg Gly Asn Ala Pro Lys Cys Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Leu Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Pro 
65                  70                  75                  80  


Lys Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  34
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized variable light chain of D2E7 v5 and canine kappa light 
       constant region

<400>  34

Glu Ile Gln Met Thr Gln Ser Pro Thr Leu Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Arg Gly Asn Ala Pro Lys Cys Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Leu Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Pro 
65                  70                  75                  80  


Lys Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Asn Asp Ala Gln 
            100                 105                 110         


Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly 
        115                 120                 125             


Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser 
            180                 185                 190         


Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe 
        195                 200                 205             


Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215         


<210>  35
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain framework region LC-FR2 of KBA VL v5

<400>  35

Trp Tyr Gln Gln Lys Arg Gly Asn Ala Pro Lys Cys Leu Ile Tyr 
1               5                   10                  15  


<210>  36
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized variable light chain of D2E7 v6 and  canine kappa light
       constant region with leader

<400>  36

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Thr Pro Leu Ser 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Pro Val Ser Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Gly Ile Arg Asn Tyr Leu Ala Trp Tyr Leu Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ser Pro Arg Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg 
                85                  90                  95      


Ile Gly Arg Leu Glu Ala Glu Asp Ala Ala Ile Tyr Tyr Cys Gln Arg 
            100                 105                 110         


Tyr Asn Arg Ala Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro 
    130                 135                 140                 


Asp Gln Leu His Thr Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser 
145                 150                 155                 160 


Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile 
                165                 170                 175     


Gln Asp Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu 
        195                 200                 205             


Ser His Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser 
    210                 215                 220                 


Thr Leu Ile Lys Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
225                 230                 235                 


<210>  37
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized variable light chain of D2E7 v6 (KBA VL v6)

<400>  37

Asp Ile Gln Met Thr Gln Thr Pro Leu Ser Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Pro Val Ser Ile Ser Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Gly Arg Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Ile Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  38
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized variable light chain of D2E7 v6 and canine kappa light 
       constant region

<400>  38

Asp Ile Gln Met Thr Gln Thr Pro Leu Ser Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Pro Val Ser Ile Ser Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Gly Arg Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Ile Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Asn Asp Ala Gln 
            100                 105                 110         


Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly 
        115                 120                 125             


Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser 
            180                 185                 190         


Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe 
        195                 200                 205             


Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215         


<210>  39
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain framework region LC-FR2 of KBA VL v6

<400>  39

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  40
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric variable light chain of D2E7 and canine lambda light 
       constant region with leader

<400>  40

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn 
            100                 105                 110         


Arg Ala Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  41
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric variable light chain of D2E7 and canine lambda light 
       constant region

<400>  41

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  42
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized variable light chain of D2E7 v7 and canine kappa light 
       constant region with leader

<400>  42

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser 
            20                  25                  30          


Ala Ser Pro Glu Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Arg Tyr Asn 
            100                 105                 110         


Arg Ala Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln 
    130                 135                 140                 


Leu His Thr Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr 
145                 150                 155                 160 


Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp 
                165                 170                 175     


Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His 
        195                 200                 205             


Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu 
    210                 215                 220                 


Ile Lys Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
225                 230                 235         


<210>  43
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized variable light chain of D2E7 v7 (KBA VL v7)

<400>  43

Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Pro Glu 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  44
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized variable light chain of D2E7 v7 and canine kappa light 
       constant region

<400>  44

Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Pro Glu 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Asn Asp Ala Gln 
            100                 105                 110         


Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly 
        115                 120                 125             


Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser 
            180                 185                 190         


Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe 
        195                 200                 205             


Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215         


<210>  45
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain framework region LC-FR2 of KBA VL v7

<400>  45

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  46
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized variable light chain of D2E7 v8

<400>  46

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Gly Arg Val Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Gly Ile Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Val Arg 
            100                 105         


<210>  47
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain of mouse clone cA2 (Infliximab)

<400>  47

Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Phe Val Gly Ser Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Met Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Thr Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser His Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Asn Leu Glu Val Lys 
            100                 105         


<210>  48
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain of mouse clone cA2 (Infliximab)

<400>  48

Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Ile Phe Ser Asn His 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ser Ile Asn Ser Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ala 
65                  70                  75                  80  


Val Tyr Leu Gln Met Thr Asp Leu Arg Thr Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asn Tyr Tyr Gly Ser Thr Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  49
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain CDR L1 of cA2

<400>  49

Arg Ala Ser Gln Phe Val Gly Ser Ser Ile His 
1               5                   10      


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain CDR L2 of cA2

<400>  50

Tyr Ala Ser Glu Ser Met Ser 
1               5           


<210>  51
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain CDR L3 of cA2

<400>  51

Gln Gln Ser His Ser Trp Pro Phe Thr 
1               5                   


<210>  52
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain CDR H1 of cA2

<400>  52

Asn His Trp Met Asn 
1               5   


<210>  53
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain CDR H2 of cA2

<400>  53

Glu Ile Arg Ser Lys Ser Ile Asn Ser Ala Thr His Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  54
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain CDR H3 of cA2

<400>  54

Asn Tyr Tyr Gly Ser Thr Tyr Asp Tyr 
1               5                   


<210>  55
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized variable light chain of cA2 v1

<400>  55

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Ser Ile Ser Cys Arg Ala Ser Gln Phe Val Gly Ser Ser 
            20                  25                  30          


Ile His Trp Phe Arg Gln Lys Pro Gly Gln Ser Pro Gln Arg Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Met Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Asn Thr Val Glu Ala 
65                  70                  75                  80  


Asp Asp Thr Gly Val Tyr Tyr Cys Gln Gln Ser His Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  56
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized variable light chain of cA2 v2

<400>  56

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Thr Val Ser Phe Ser Cys Arg Ala Ser Gln Phe Val Gly Ser Ser 
            20                  25                  30          


Ile His Trp Phe Arg Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Met Ser Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Thr Val Glu Ala 
65                  70                  75                  80  


Asp Asp Ile Ala Val Tyr Tyr Cys Gln Gln Ser His Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  57
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized variable heavy chain of mouse clone cA2 v1

<400>  57

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Ile Phe Ser Asn His 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ser Ile Asn Ser Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asn Tyr Tyr Gly Ser Thr Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  58
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized variable heavy chain of mouse clone cA2 v2

<400>  58

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Ile Phe Ser Asn His 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ser Ile Asn Ser Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asn Tyr Tyr Gly Ser Thr Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  59
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized variable light chain of cA2 v1 and canine kappa light 
       constant region

<400>  59

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Ser Ile Ser Cys Arg Ala Ser Gln Phe Val Gly Ser Ser 
            20                  25                  30          


Ile His Trp Phe Arg Gln Lys Pro Gly Gln Ser Pro Gln Arg Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Met Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Asn Thr Val Glu Ala 
65                  70                  75                  80  


Asp Asp Thr Gly Val Tyr Tyr Cys Gln Gln Ser His Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Asn Asp Ala Gln 
            100                 105                 110         


Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly 
        115                 120                 125             


Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser 
            180                 185                 190         


Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe 
        195                 200                 205             


Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215         


<210>  60
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized variable light chain of cA2 v2 and canine kappa light 
       constant region

<400>  60

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Thr Val Ser Phe Ser Cys Arg Ala Ser Gln Phe Val Gly Ser Ser 
            20                  25                  30          


Ile His Trp Phe Arg Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Met Ser Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Thr Val Glu Ala 
65                  70                  75                  80  


Asp Asp Ile Ala Val Tyr Tyr Cys Gln Gln Ser His Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Asn Asp Ala Gln 
            100                 105                 110         


Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly 
        115                 120                 125             


Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser 
            180                 185                 190         


Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe 
        195                 200                 205             


Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215         


<210>  61
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized variable heavy chain of cA2 v1 and canine IgG-B 
       constant region

<400>  61

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Ile Phe Ser Asn His 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ser Ile Asn Ser Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asn Tyr Tyr Gly Ser Thr Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala 
    130                 135                 140                 


Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro 
            180                 185                 190         


Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly 
    210                 215                 220                 


Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu 
            260                 265                 270         


Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys 
        275                 280                 285             


Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu 
305                 310                 315                 320 


Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser 
                325                 330                 335     


Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro 
            340                 345                 350         


Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp 
    370                 375                 380                 


Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg 
385                 390                 395                 400 


Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile 
            420                 425                 430         


Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser 
        435                 440                 445             


Leu Ser His Ser Pro Gly Lys 
    450                 455 


<210>  62
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized variable heavy chain of cA2 v2 and canine IgG-B 
       constant region

<400>  62

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Ile Phe Ser Asn His 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ser Ile Asn Ser Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asn Tyr Tyr Gly Ser Thr Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala 
    130                 135                 140                 


Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro 
            180                 185                 190         


Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly 
    210                 215                 220                 


Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu 
            260                 265                 270         


Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys 
        275                 280                 285             


Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu 
305                 310                 315                 320 


Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser 
                325                 330                 335     


Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro 
            340                 345                 350         


Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp 
    370                 375                 380                 


Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg 
385                 390                 395                 400 


Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile 
            420                 425                 430         


Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser 
        435                 440                 445             


Leu Ser His Ser Pro Gly Lys 
    450                 455 


<210>  63
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary caninized variable heavy chain of D2E7 and variant 
       canine IgG-B (FcRn long-acting Q to Y) constant region with 
       leader

<400>  63

Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Asp Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Gln Trp Val Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala 
65                  70                  75                  80  


Asp Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr 
    130                 135                 140                 


Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly 
145                 150                 155                 160 


Ser Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met 
        195                 200                 205             


Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn 
    210                 215                 220                 


Val Ala His Pro Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys 
225                 230                 235                 240 


Arg Glu Asn Gly Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro 
                245                 250                 255     


Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe 
    290                 295                 300                 


Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His 
                325                 330                 335     


Tyr Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys 
            340                 345                 350         


Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln 
        355                 360                 365             


Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu 
    370                 375                 380                 


Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro 
385                 390                 395                 400 


Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu 
                405                 410                 415     


Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly 
        435                 440                 445             


Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
465                 470                 475 


<210>  64
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary caninized variable heavy chain of D2E7 and variant 
       canine IgG-B (FcRn long-acting Q to Y) constant region

<400>  64

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val 
    130                 135                 140                 


Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val 
            180                 185                 190         


Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His 
        195                 200                 205             


Pro Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn 
    210                 215                 220                 


Gly Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly 
        275                 280                 285             


Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn 
    290                 295                 300                 


Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Tyr Asp Trp 
305                 310                 315                 320 


Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro 
                325                 330                 335     


Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln 
            340                 345                 350         


Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn 
        355                 360                 365             


Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile 
    370                 375                 380                 


Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr 
385                 390                 395                 400 


Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe 
            420                 425                 430         


Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu 
        435                 440                 445             


Ser Leu Ser His Ser Pro Gly Lys 
    450                 455     


<210>  65
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain CDR L1 of alphaD11

<400>  65

Arg Ala Ser Glu Asp Ile Tyr Asn Ala Leu Ala 
1               5                   10      


<210>  66
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain CDR L2 of alphaD11

<400>  66

Tyr Asn Thr Asp Thr Leu His Thr 
1               5               


<210>  67
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain CDR L3 of alphaD11

<400>  67

Gln His Tyr Phe Gly Tyr Pro Arg Thr 
1               5                   


<210>  68
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain CDR H1 of alphaD11

<400>  68

Thr Val Ser Gly Phe Ser Leu Thr Asn Asn Asn Val Asn 
1               5                   10              


<210>  69
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain CDR H2 of alphaD11

<400>  69

Gly Val Trp Ala Gly Gly Ala Thr Asp 
1               5                   


<210>  70
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain CDR H3 of alphaD11

<400>  70

Ala Arg Asp Gly Gly Tyr Ser Ser Ser Thr Leu Tyr Ala Met Asp Ala 
1               5                   10                  15      


<210>  71
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain of rat alphaD11

<400>  71

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Glu Cys Arg Ala Ser Glu Asp Ile Tyr Asn Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asp Thr Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Val Ala Ser Tyr Phe Cys Gln His Tyr Phe Gly Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  72
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain of rat alphaD11

<400>  72

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Asn 
            20                  25                  30          


Asn Val Asn Trp Val Arg Gln Ala Thr Gly Arg Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Val Trp Ala Gly Gly Ala Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met His Ser Leu Gln Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Gly Tyr Ser Ser Ser Thr Leu Tyr Ala Met Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  73
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary caninized variable light chain of alphaD11

<400>  73

Glu Ile Val Met Thr Gln Ser Pro Gly Ser Leu Ala Gly Ser Ala Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Asn Cys Arg Ala Ser Glu Asp Ile Tyr Asn Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Glu Arg Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asp Thr Leu His Thr Gly Val Pro Ala Arg Phe Ser Ser 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Gly Asp Tyr Phe Cys Gln His Tyr Phe Gly Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Val Glu Leu Lys 
            100                 105         


<210>  74
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary caninized variable heavy chain of alphaD11

<400>  74

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Ala Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Ser Leu Thr Asn Asn 
            20                  25                  30          


Asn Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Val Trp Ala Gly Gly Ala Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Gly Tyr Ser Ser Ser Thr Leu Tyr Ala Met Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  75
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain CDR H1 of caninized alphaD11

<400>  75

Val Ala Ser Gly Phe Ser Leu Thr Asn Asn Asn Val Asn 
1               5                   10              


<210>  76
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary caninized variable light chain of alphaD11and canine 
       kappa light constant region with leader

<400>  76

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Ile Val Met Thr Gln Ser Pro Gly Ser Leu Ala 
            20                  25                  30          


Gly Ser Ala Gly Glu Ser Val Ser Ile Asn Cys Arg Ala Ser Glu Asp 
        35                  40                  45              


Ile Tyr Asn Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Glu Arg Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Asn Thr Asp Thr Leu His Thr Gly Val Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
                85                  90                  95      


Asn Leu Gln Ala Glu Asp Val Gly Asp Tyr Phe Cys Gln His Tyr Phe 
            100                 105                 110         


Gly Tyr Pro Arg Thr Phe Gly Ala Gly Thr Lys Val Glu Leu Lys Arg 
        115                 120                 125             


Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln 
    130                 135                 140                 


Leu His Thr Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr 
145                 150                 155                 160 


Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp 
                165                 170                 175     


Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His 
        195                 200                 205             


Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu 
    210                 215                 220                 


Ile Lys Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
225                 230                 235         


<210>  77
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary caninized variable light chain of alphaD11and canine 
       kappa light constant region

<400>  77

Glu Ile Val Met Thr Gln Ser Pro Gly Ser Leu Ala Gly Ser Ala Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Asn Cys Arg Ala Ser Glu Asp Ile Tyr Asn Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Glu Arg Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asp Thr Leu His Thr Gly Val Pro Ala Arg Phe Ser Ser 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Gly Asp Tyr Phe Cys Gln His Tyr Phe Gly Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Val Glu Leu Lys Arg Asn Asp Ala Gln 
            100                 105                 110         


Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly 
        115                 120                 125             


Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser 
            180                 185                 190         


Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe 
        195                 200                 205             


Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215         


<210>  78
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary caninized variable heavy chain of alphaD11and variant 
       canine IgG-B (FcRn long-acting Q to Y, C1q-, CD16-) constant 
       region with leader

<400>  78

Met Ala Val Leu Gly Leu Leu Leu Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys 
            20                  25                  30          


Pro Ala Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Asn Asn Asn Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Gly Val Trp Ala Gly Gly Ala Thr Asp Tyr Asn Ser 
65                  70                  75                  80  


Ala Leu Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Asp Gly Gly Tyr Ser Ser Ser Thr Leu Tyr Ala Met 
        115                 120                 125             


Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser 
145                 150                 155                 160 


Gly Ser Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Met Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys 
    210                 215                 220                 


Asn Val Ala His Pro Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro 
225                 230                 235                 240 


Lys Arg Glu Asn Gly Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys 
                245                 250                 255     


Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
    290                 295                 300                 


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
                325                 330                 335     


His Tyr Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn 
            340                 345                 350         


Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
        355                 360                 365             


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
    370                 375                 380                 


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
385                 390                 395                 400 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
                405                 410                 415     


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
            420                 425                 430         


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
        435                 440                 445             


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
465                 470                 475     


<210>  79
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary caninized variable heavy chain of alphaD11and variant 
       canine IgG-B (FcRn long-acting Q to Y, C1q-, CD16-) constant 
       region

<400>  79

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Ala Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Ser Leu Thr Asn Asn 
            20                  25                  30          


Asn Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Val Trp Ala Gly Gly Ala Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Gly Tyr Ser Ser Ser Thr Leu Tyr Ala Met Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr 
    130                 135                 140                 


Val Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr 
            180                 185                 190         


Val Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala 
        195                 200                 205             


His Pro Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu 
    210                 215                 220                 


Asn Gly Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp 
        275                 280                 285             


Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Tyr Asp 
305                 310                 315                 320 


Trp Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn Ile Gly Leu 
                325                 330                 335     


Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His 
            340                 345                 350         


Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys 
        355                 360                 365             


Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp 
    370                 375                 380                 


Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys 
385                 390                 395                 400 


Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr 
            420                 425                 430         


Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Glu Ser Leu Ser His Ser Pro Gly Lys 
    450                 455         


<210>  80
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary bi-specific NGF and TNF antibody with leader (Anti-NGF 
       + Fc IgGB (FcRn long-acting Q to Y, C1q-, CD16-) + anti-TNF ScFv)

<400>  80

Met Ala Val Leu Gly Leu Leu Leu Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys 
            20                  25                  30          


Pro Ala Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Asn Asn Asn Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Gly Val Trp Ala Gly Gly Ala Thr Asp Tyr Asn Ser 
65                  70                  75                  80  


Ala Leu Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Asp Gly Gly Tyr Ser Ser Ser Thr Leu Tyr Ala Met 
        115                 120                 125             


Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser 
145                 150                 155                 160 


Gly Ser Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Met Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys 
    210                 215                 220                 


Asn Val Ala His Pro Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro 
225                 230                 235                 240 


Lys Arg Glu Asn Gly Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys 
                245                 250                 255     


Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
    290                 295                 300                 


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
                325                 330                 335     


His Tyr Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn 
            340                 345                 350         


Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
        355                 360                 365             


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
    370                 375                 380                 


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
385                 390                 395                 400 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
                405                 410                 415     


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
            420                 425                 430         


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
        435                 440                 445             


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys Gly Gly Gly Gly 
465                 470                 475                 480 


Ser Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val 
                485                 490                 495     


Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr 
            500                 505                 510         


Phe Asp Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
        515                 520                 525             


Leu Gln Trp Val Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr 
    530                 535                 540                 


Ala Asp Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
545                 550                 555                 560 


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
                565                 570                 575     


Val Tyr Tyr Cys Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu 
            580                 585                 590         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        595                 600                 605             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Asp Ile 
    610                 615                 620                 


Val Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Pro Glu Glu Lys 
625                 630                 635                 640 


Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr Leu Ala 
                645                 650                 655     


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala 
            660                 665                 670         


Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
        675                 680                 685             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp 
    690                 695                 700                 


Val Ala Val Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr Thr Phe 
705                 710                 715                 720 


Gly Gln Gly Thr Lys Val Glu Ile Lys 
                725                 


<210>  81
<211>  710
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary bi-specific NGF and TNF antibody (Anti-NGF + Fc IgGB 
       (FcRn long-acting Q to Y, C1q-, CD16-) + anti-TNF ScFv)

<400>  81

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Ala Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Ser Leu Thr Asn Asn 
            20                  25                  30          


Asn Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Val Trp Ala Gly Gly Ala Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Gly Tyr Ser Ser Ser Thr Leu Tyr Ala Met Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr 
    130                 135                 140                 


Val Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr 
            180                 185                 190         


Val Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala 
        195                 200                 205             


His Pro Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu 
    210                 215                 220                 


Asn Gly Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp 
        275                 280                 285             


Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Tyr Asp 
305                 310                 315                 320 


Trp Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn Ile Gly Leu 
                325                 330                 335     


Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His 
            340                 345                 350         


Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys 
        355                 360                 365             


Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp 
    370                 375                 380                 


Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys 
385                 390                 395                 400 


Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr 
            420                 425                 430         


Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Glu Ser Leu Ser His Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly 
    450                 455                 460                 


Gly Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly 
465                 470                 475                 480 


Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Asp 
                485                 490                 495     


Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp 
            500                 505                 510         


Val Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ala 
        515                 520                 525             


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu 
    530                 535                 540                 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
545                 550                 555                 560 


Cys Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp 
                565                 570                 575     


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Asp Ile Val Met Thr 
        595                 600                 605             


Gln Ser Pro Ala Ser Leu Ser Ala Ser Pro Glu Glu Lys Val Thr Ile 
    610                 615                 620                 


Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr Leu Ala Trp Tyr Gln 
625                 630                 635                 640 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr 
                645                 650                 655     


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
            660                 665                 670         


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Val Ala Val 
        675                 680                 685             


Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr Thr Phe Gly Gln Gly 
    690                 695                 700                 


Thr Lys Val Glu Ile Lys 
705                 710 


<210>  82
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary bi-specific NGF and TNF antibody with leader (Anti-TNF 
       + Fc IgGB (FcRn long-acting Q to Y, C1q-, CD16-) + anti-NGF ScFv)

<400>  82

Met Ala Val Leu Gly Leu Leu Leu Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Asp Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Gln Trp Val Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala 
65                  70                  75                  80  


Asp Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr 
    130                 135                 140                 


Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly 
145                 150                 155                 160 


Ser Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met 
        195                 200                 205             


Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn 
    210                 215                 220                 


Val Ala His Pro Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys 
225                 230                 235                 240 


Arg Glu Asn Gly Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro 
                245                 250                 255     


Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe 
    290                 295                 300                 


Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His 
                325                 330                 335     


Tyr Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn Ile 
            340                 345                 350         


Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln 
        355                 360                 365             


Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu 
    370                 375                 380                 


Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro 
385                 390                 395                 400 


Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu 
                405                 410                 415     


Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly 
        435                 440                 445             


Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys Gly Gly Gly Gly Ser 
465                 470                 475                 480 


Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys 
                485                 490                 495     


Pro Ala Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Ser Leu 
            500                 505                 510         


Thr Asn Asn Asn Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
        515                 520                 525             


Glu Trp Met Gly Gly Val Trp Ala Gly Gly Ala Thr Asp Tyr Asn Ser 
    530                 535                 540                 


Ala Leu Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
545                 550                 555                 560 


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                565                 570                 575     


Tyr Cys Ala Arg Asp Gly Gly Tyr Ser Ser Ser Thr Leu Tyr Ala Met 
            580                 585                 590         


Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        595                 600                 605             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Glu Ile 
    610                 615                 620                 


Val Met Thr Gln Ser Pro Gly Ser Leu Ala Gly Ser Ala Gly Glu Ser 
625                 630                 635                 640 


Val Ser Ile Asn Cys Arg Ala Ser Glu Asp Ile Tyr Asn Ala Leu Ala 
                645                 650                 655     


Trp Tyr Gln Gln Lys Pro Gly Glu Arg Pro Lys Leu Leu Ile Tyr Asn 
            660                 665                 670         


Thr Asp Thr Leu His Thr Gly Val Pro Ala Arg Phe Ser Ser Ser Gly 
        675                 680                 685             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Leu Gln Ala Glu Asp 
    690                 695                 700                 


Val Gly Asp Tyr Phe Cys Gln His Tyr Phe Gly Tyr Pro Arg Thr Phe 
705                 710                 715                 720 


Gly Ala Gly Thr Lys Val Glu Leu Lys 
                725                 


<210>  83
<211>  710
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary bi-specific NGF and TNF antibody (Anti-TNF + Fc IgGB 
       (FcRn long-acting Q to Y, C1q-, CD16-) + anti-NGF ScFv)

<400>  83

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val 
    130                 135                 140                 


Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val 
            180                 185                 190         


Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His 
        195                 200                 205             


Pro Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn 
    210                 215                 220                 


Gly Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly 
        275                 280                 285             


Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn 
    290                 295                 300                 


Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Tyr Asp Trp 
305                 310                 315                 320 


Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn Ile Gly Leu Pro 
                325                 330                 335     


Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln 
            340                 345                 350         


Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn 
        355                 360                 365             


Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile 
    370                 375                 380                 


Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr 
385                 390                 395                 400 


Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe 
            420                 425                 430         


Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu 
        435                 440                 445             


Ser Leu Ser His Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly 
    450                 455                 460                 


Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Ala Gly 
465                 470                 475                 480 


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Ser Leu Thr Asn Asn 
                485                 490                 495     


Asn Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
            500                 505                 510         


Gly Gly Val Trp Ala Gly Gly Ala Thr Asp Tyr Asn Ser Ala Leu Lys 
        515                 520                 525             


Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
    530                 535                 540                 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
545                 550                 555                 560 


Arg Asp Gly Gly Tyr Ser Ser Ser Thr Leu Tyr Ala Met Asp Ala Trp 
                565                 570                 575     


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Glu Ile Val Met Thr 
        595                 600                 605             


Gln Ser Pro Gly Ser Leu Ala Gly Ser Ala Gly Glu Ser Val Ser Ile 
    610                 615                 620                 


Asn Cys Arg Ala Ser Glu Asp Ile Tyr Asn Ala Leu Ala Trp Tyr Gln 
625                 630                 635                 640 


Gln Lys Pro Gly Glu Arg Pro Lys Leu Leu Ile Tyr Asn Thr Asp Thr 
                645                 650                 655     


Leu His Thr Gly Val Pro Ala Arg Phe Ser Ser Ser Gly Ser Gly Thr 
            660                 665                 670         


Asp Phe Thr Leu Thr Ile Asn Asn Leu Gln Ala Glu Asp Val Gly Asp 
        675                 680                 685             


Tyr Phe Cys Gln His Tyr Phe Gly Tyr Pro Arg Thr Phe Gly Ala Gly 
    690                 695                 700                 


Thr Lys Val Glu Leu Lys 
705                 710 


