                         SEQUENCE LISTING

<110>  The Broad Institute, Inc.
       President and Fellows of Harvard College
       Children's Medical Center Corporation
 
<120>  EVOLUTION OF BOTULINUM NEUROTOXIN PROTEASES

<130>  B1195.70116WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 63/127,340
<151>  2020-12-18

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  411
<212>  PRT
<213>  Unknown

<220>
<223>  Botulinum Neurotoxin E

<400>  1

Met Pro Lys Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asp Arg 
1               5                   10                  15      


Thr Ile Leu Tyr Ile Lys Pro Gly Gly Cys Gln Glu Phe Tyr Lys Ser 
            20                  25                  30          


Phe Asn Ile Met Lys Asn Ile Trp Ile Ile Pro Glu Arg Asn Val Ile 
        35                  40                  45              


Gly Thr Thr Pro Gln Asp Phe His Pro Pro Thr Ser Leu Lys Asn Gly 
    50                  55                  60                  


Asp Ser Ser Tyr Tyr Asp Pro Asn Tyr Leu Gln Ser Asp Glu Glu Lys 
65                  70                  75                  80  


Asp Arg Phe Leu Lys Ile Val Thr Lys Ile Phe Asn Arg Ile Asn Asn 
                85                  90                  95      


Asn Leu Ser Gly Gly Ile Leu Leu Glu Glu Leu Ser Lys Ala Asn Pro 
            100                 105                 110         


Tyr Leu Gly Asn Asp Asn Thr Pro Asp Asn Gln Phe His Ile Gly Asp 
        115                 120                 125             


Ala Ser Ala Val Glu Ile Lys Phe Ser Asn Gly Ser Gln His Ile Leu 
    130                 135                 140                 


Leu Pro Asn Val Ile Ile Met Gly Ala Glu Pro Asp Leu Phe Glu Thr 
145                 150                 155                 160 


Asn Ser Ser Asn Ile Ser Leu Arg Asn Asn Tyr Met Pro Ser Asn His 
                165                 170                 175     


Gly Phe Gly Ser Ile Ala Ile Val Thr Phe Ser Pro Glu Tyr Ser Phe 
            180                 185                 190         


Arg Phe Asn Asp Asn Ser Ile Asn Glu Phe Ile Gln Asp Pro Ala Leu 
        195                 200                 205             


Thr Leu Met His Glu Leu Ile His Ser Leu His Gly Leu Tyr Gly Ala 
    210                 215                 220                 


Lys Gly Ile Thr Thr Thr Cys Ile Ile Thr Gln Gln Gln Asn Pro Leu 
225                 230                 235                 240 


Ile Thr Asn Arg Lys Gly Ile Asn Ile Glu Glu Phe Leu Thr Phe Gly 
                245                 250                 255     


Gly Asn Asp Leu Asn Ile Ile Thr Val Ala Gln Tyr Asn Asp Ile Tyr 
            260                 265                 270         


Thr Asn Leu Leu Asn Asp Tyr Arg Lys Ile Ala Ser Lys Leu Ser Lys 
        275                 280                 285             


Val Gln Val Ser Asn Pro Gln Leu Asn Pro Tyr Lys Asp Ile Phe Gln 
    290                 295                 300                 


Glu Lys Tyr Gly Leu Asp Lys Asp Ala Ser Gly Ile Tyr Ser Val Asn 
305                 310                 315                 320 


Ile Asn Lys Phe Asp Asp Ile Leu Lys Lys Leu Tyr Ser Phe Thr Glu 
                325                 330                 335     


Phe Asp Leu Ala Thr Lys Phe Gln Val Lys Cys Arg Glu Thr Tyr Ile 
            340                 345                 350         


Gly Gln Tyr Lys Tyr Phe Lys Leu Ser Asn Leu Leu Asn Asp Ser Ile 
        355                 360                 365             


Tyr Asn Ile Ser Glu Gly Tyr Asn Ile Asn Asn Leu Lys Val Asn Phe 
    370                 375                 380                 


Arg Gly Gln Asn Ala Asn Leu Asn Pro Arg Ile Ile Lys Pro Ile Thr 
385                 390                 395                 400 


Gly Arg Gly Leu Val Lys Lys Ile Ile Arg Phe 
                405                 410     


<210>  2
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asp Ser Gly Arg Asp Phe Leu Thr Leu His Gly Leu Gln Asp Asp 
1               5                   10                  15      


Glu Asp Leu Gln Ala Leu Leu Lys Gly Ser Gln Leu Leu Lys Val Lys 
            20                  25                  30          


Ser Ser Ser Trp Arg Arg Glu Arg Phe Tyr Lys Leu Gln Glu Asp Cys 
        35                  40                  45              


Lys Thr Ile Trp Gln Glu Ser Arg Lys Val Met Arg Thr Pro Glu Ser 
    50                  55                  60                  


Gln Leu Phe Ser Ile Glu Asp Ile Gln Glu Val Arg Met Gly His Arg 
65                  70                  75                  80  


Thr Glu Gly Leu Glu Lys Phe Ala Arg Asp Val Pro Glu Asp Arg Cys 
                85                  90                  95      


Phe Ser Ile Val Phe Lys Asp Gln Arg Asn Thr Leu Asp Leu Ile Ala 
            100                 105                 110         


Pro Ser Pro Ala Asp Ala Gln His Trp Val Leu Gly Leu His Lys Ile 
        115                 120                 125             


Ile His His Ser Gly Ser Met Asp Gln Arg Gln Lys Leu Gln His Trp 
    130                 135                 140                 


Ile His Ser Cys Leu Arg Lys Ala Asp Lys Asn Lys Asp Asn Lys Met 
145                 150                 155                 160 


Ser Phe Lys Glu Leu Gln Asn Phe Leu Lys 
                165                 170 


<210>  3
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Met Pro Lys Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asp Arg 
1               5                   10                  15      


Thr Ile Leu Tyr Ile Lys Pro Gly Gly Tyr His Glu Phe Tyr Lys Ser 
            20                  25                  30          


Phe Asn Ile Met Lys Asn Ile Trp Ile Ile Pro Glu Arg Asn Val Ile 
        35                  40                  45              


Gly Thr Thr Pro Gln Asp Phe His Pro Pro Thr Ser Leu Lys Asn Gly 
    50                  55                  60                  


Asp Ser Ser Tyr Tyr Asp Pro Asn Tyr Leu Gln Ser Asp Glu Glu Lys 
65                  70                  75                  80  


Asp Arg Phe Leu Lys Ile Val Thr Lys Ile Phe Asn Arg Ile Asn Asn 
                85                  90                  95      


Asn Leu Ala Gly Ser Ile Leu Leu Glu Glu Leu Ser Lys Ala Asn Pro 
            100                 105                 110         


Tyr Leu Gly Asn Asp Asp Thr Pro Asp Asn Gln Phe His Ile Gly Asp 
        115                 120                 125             


Ala Ser Ala Val Glu Ile Lys Phe Ser Asn Gly Ser Gln His Ile Leu 
    130                 135                 140                 


Leu Pro Asn Val Ile Ile Met Gly Ala Glu Pro Asn Leu Phe Leu Thr 
145                 150                 155                 160 


Tyr Gln Arg Asn Ile Ser Leu Arg Asn Asn Tyr Lys Pro Ser Asn His 
                165                 170                 175     


Gly Phe Gly Ser Ile Ala Ile Val Thr Phe Ser Pro Glu Tyr Ser Phe 
            180                 185                 190         


Arg Phe Asn Asp Asn Ser Ile Asn Glu Phe Ile Gln Asp Pro Ala Leu 
        195                 200                 205             


Thr Leu Met His Glu Leu Ile His Ser Leu His Gly Leu Tyr Gly Ala 
    210                 215                 220                 


Lys Gly Ile Thr Thr Thr Cys Thr Ile Thr Gln Gln Gln Asn Pro Leu 
225                 230                 235                 240 


Ile Thr Asn Arg Lys Gly Ile Lys Ile Glu Glu Phe Leu Thr Phe Gly 
                245                 250                 255     


Gly Asn Asp Leu Asn Ile Ile Thr Val Ala Gln Tyr Asn Asp Ile Tyr 
            260                 265                 270         


Thr Asn Leu Leu Asn Asp Tyr Arg Lys Ile Ala Ser Lys Leu Ser Lys 
        275                 280                 285             


Val Gln Val Ser Asn Pro Gln Leu Asn Pro Tyr Lys Asp Ile Phe Gln 
    290                 295                 300                 


Glu Lys Tyr Gly Leu Asp Lys Asp Ala Ser Gly Ile Tyr Ser Val Asn 
305                 310                 315                 320 


Ile Asn Lys Phe Asp Asp Ile Leu Lys Lys Leu Tyr Ser Phe Thr Glu 
                325                 330                 335     


Phe Asp Leu Ala Thr Lys Phe Gln Val Lys Cys Arg Glu Thr Tyr Ile 
            340                 345                 350         


Gly Arg Pro Lys Phe Phe Lys Leu Ser Asn Leu Leu Asn Asp Ser Ile 
        355                 360                 365             


Tyr Asn Ile Ser Glu Gly Tyr Asn Ile Asn Asn Leu Lys Val Asn Phe 
    370                 375                 380                 


Arg Gly Gln Asn Ala Asn Leu Asn Pro Arg Ile Ile Lys Pro Ile Thr 
385                 390                 395                 400 


Gly Arg Gly Leu Val Lys Lys Ile Ile Arg Phe 
                405                 410     


<210>  4
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Met Pro Lys Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asp Arg 
1               5                   10                  15      


Thr Ile Leu Tyr Ile Lys Pro Gly Gly Tyr His Glu Phe Tyr Lys Ser 
            20                  25                  30          


Phe Asn Ile Met Lys Asn Ile Trp Ile Ile Pro Glu Arg Asn Val Ile 
        35                  40                  45              


Gly Thr Thr Pro Gln Asp Phe His Pro Pro Thr Ser Leu Lys Asn Gly 
    50                  55                  60                  


Asp Ser Ser Tyr Tyr Asp Pro Asn Tyr Leu Gln Ser Asp Glu Glu Lys 
65                  70                  75                  80  


Asp Arg Phe Leu Lys Ile Val Thr Lys Ile Phe Asn Arg Ile Asn Asn 
                85                  90                  95      


Asn Leu Ala Gly Ser Ile Leu Leu Glu Glu Leu Ser Lys Ala Asn Pro 
            100                 105                 110         


Tyr Leu Gly Asn Asp Asp Thr Pro Asp Asn Gln Phe His Ile Gly Asp 
        115                 120                 125             


Ala Ser Ala Val Glu Ile Lys Phe Ser Asn Gly Ser Gln His Ile Leu 
    130                 135                 140                 


Leu Pro Asn Val Ile Ile Met Gly Ala Glu Pro Asn Leu Phe Leu Thr 
145                 150                 155                 160 


Tyr Gln Arg Asn Ile Ser Leu Arg Asn Asn Tyr Lys Pro Ser Asn His 
                165                 170                 175     


Gly Phe Gly Ser Ile Ala Ile Val Thr Phe Ser Pro Glu Tyr Ser Phe 
            180                 185                 190         


Arg Phe Asn Asp Asn Ser Ile Asn Glu Phe Ile Gln Asp Pro Ala Leu 
        195                 200                 205             


Thr Leu Met His Glu Leu Ile His Ser Leu His Gly Leu Tyr Gly Ala 
    210                 215                 220                 


Lys Gly Ile Thr Thr Thr Cys Thr Ile Thr Gln Gln Gln Asn Pro Leu 
225                 230                 235                 240 


Ile Thr Asn Arg Lys Gly Ile Lys Ile Glu Glu Phe Leu Thr Phe Gly 
                245                 250                 255     


Gly Asn Asp Leu Asn Ile Ile Thr Val Ala Gln Tyr Asn Asp Ile Tyr 
            260                 265                 270         


Thr Asn Leu Leu Asn Asp Tyr Arg Lys Ile Ala Ser Lys Leu Ser Lys 
        275                 280                 285             


Val Gln Val Ser Asn Pro Gln Leu Asn Pro Tyr Lys Asp Ile Phe Gln 
    290                 295                 300                 


Glu Lys Tyr Gly Leu Asp Lys Asp Ala Ser Gly Ile Tyr Ser Val Asn 
305                 310                 315                 320 


Ile Asn Lys Phe Asp Asp Ile Leu Lys Lys Leu Tyr Ser Phe Thr Glu 
                325                 330                 335     


Phe Asp Leu Ala Thr Lys Phe Gln Val Lys Cys Arg Glu Thr Tyr Ile 
            340                 345                 350         


Gly Arg Pro Lys Phe Phe Lys Leu Ser Asn Leu Leu Asn Asp Ser Ile 
        355                 360                 365             


Tyr Asn Ile Ser Glu Gly Tyr Asn Ile Asn Asn Leu Lys Val Asn Phe 
    370                 375                 380                 


Arg Gly Gln Asn Ala Asn Leu Asn Pro Arg Ile Ile Lys Pro Ile Thr 
385                 390                 395                 400 


Gly Arg Gly Leu Val Lys Lys Ile Ile Arg Phe 
                405                 410     


<210>  5
<211>  586
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Met Asp Ser Gly Arg Asp Phe Leu Thr Leu His Gly Leu Gln Asp Asp 
1               5                   10                  15      


Glu Asp Leu Gln Ala Leu Leu Lys Gly Ser Gln Leu Leu Lys Val Lys 
            20                  25                  30          


Ser Ser Ser Trp Arg Arg Glu Arg Phe Tyr Lys Leu Gln Glu Asp Cys 
        35                  40                  45              


Lys Thr Ile Trp Gln Glu Ser Arg Lys Val Met Arg Thr Pro Glu Ser 
    50                  55                  60                  


Gln Leu Phe Ser Ile Glu Asp Ile Gln Glu Val Arg Met Gly His Arg 
65                  70                  75                  80  


Thr Glu Gly Leu Glu Lys Phe Ala Arg Asp Val Pro Glu Asp Arg Cys 
                85                  90                  95      


Phe Ser Ile Val Phe Lys Asp Gln Arg Asn Thr Leu Asp Leu Ile Ala 
            100                 105                 110         


Pro Ser Pro Ala Asp Ala Gln His Trp Val Leu Gly Leu His Lys Ile 
        115                 120                 125             


Ile His His Ser Gly Ser Met Asp Gln Arg Gln Lys Leu Gln His Trp 
    130                 135                 140                 


Ile His Ser Cys Leu Arg Lys Ala Asp Lys Asn Lys Asp Asn Lys Met 
145                 150                 155                 160 


Ser Phe Lys Glu Leu Gln Asn Phe Leu Lys Gly Gly Gly Gly Ser Met 
                165                 170                 175     


Pro Lys Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asp Arg Thr 
            180                 185                 190         


Ile Leu Tyr Ile Lys Pro Gly Gly Tyr His Glu Phe Tyr Lys Ser Phe 
        195                 200                 205             


Asn Ile Met Lys Asn Ile Trp Ile Ile Pro Glu Arg Asn Val Ile Gly 
    210                 215                 220                 


Thr Thr Pro Gln Asp Phe His Pro Pro Thr Ser Leu Lys Asn Gly Asp 
225                 230                 235                 240 


Ser Ser Tyr Tyr Asp Pro Asn Tyr Leu Gln Ser Asp Glu Glu Lys Asp 
                245                 250                 255     


Arg Phe Leu Lys Ile Val Thr Lys Ile Phe Asn Arg Ile Asn Asn Asn 
            260                 265                 270         


Leu Ala Gly Ser Ile Leu Leu Glu Glu Leu Ser Lys Ala Asn Pro Tyr 
        275                 280                 285             


Leu Gly Asn Asp Asp Thr Pro Asp Asn Gln Phe His Ile Gly Asp Ala 
    290                 295                 300                 


Ser Ala Val Glu Ile Lys Phe Ser Asn Gly Ser Gln His Ile Leu Leu 
305                 310                 315                 320 


Pro Asn Val Ile Ile Met Gly Ala Glu Pro Asn Leu Phe Leu Thr Tyr 
                325                 330                 335     


Gln Arg Asn Ile Ser Leu Arg Asn Asn Tyr Lys Pro Ser Asn His Gly 
            340                 345                 350         


Phe Gly Ser Ile Ala Ile Val Thr Phe Ser Pro Glu Tyr Ser Phe Arg 
        355                 360                 365             


Phe Asn Asp Asn Ser Ile Asn Glu Phe Ile Gln Asp Pro Ala Leu Thr 
    370                 375                 380                 


Leu Met His Glu Leu Ile His Ser Leu His Gly Leu Tyr Gly Ala Lys 
385                 390                 395                 400 


Gly Ile Thr Thr Thr Cys Thr Ile Thr Gln Gln Gln Asn Pro Leu Ile 
                405                 410                 415     


Thr Asn Arg Lys Gly Ile Lys Ile Glu Glu Phe Leu Thr Phe Gly Gly 
            420                 425                 430         


Asn Asp Leu Asn Ile Ile Thr Val Ala Gln Tyr Asn Asp Ile Tyr Thr 
        435                 440                 445             


Asn Leu Leu Asn Asp Tyr Arg Lys Ile Ala Ser Lys Leu Ser Lys Val 
    450                 455                 460                 


Gln Val Ser Asn Pro Gln Leu Asn Pro Tyr Lys Asp Ile Phe Gln Glu 
465                 470                 475                 480 


Lys Tyr Gly Leu Asp Lys Asp Ala Ser Gly Ile Tyr Ser Val Asn Ile 
                485                 490                 495     


Asn Lys Phe Asp Asp Ile Leu Lys Lys Leu Tyr Ser Phe Thr Glu Phe 
            500                 505                 510         


Asp Leu Ala Thr Lys Phe Gln Val Lys Cys Arg Glu Thr Tyr Ile Gly 
        515                 520                 525             


Arg Pro Lys Phe Phe Lys Leu Ser Asn Leu Leu Asn Asp Ser Ile Tyr 
    530                 535                 540                 


Asn Ile Ser Glu Gly Tyr Asn Ile Asn Asn Leu Lys Val Asn Phe Arg 
545                 550                 555                 560 


Gly Gln Asn Ala Asn Leu Asn Pro Arg Ile Ile Lys Pro Ile Thr Gly 
                565                 570                 575     


Arg Gly Leu Val Lys Lys Ile Ile Arg Phe 
            580                 585     


<210>  6
<211>  586
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Met Asp Ser Gly Arg Asp Phe Leu Thr Leu His Gly Leu Gln Asp Asp 
1               5                   10                  15      


Glu Asp Leu Gln Ala Leu Leu Lys Gly Ser Gln Leu Leu Lys Val Lys 
            20                  25                  30          


Ser Ser Ser Trp Arg Arg Glu Arg Phe Tyr Lys Leu Gln Glu Asp Cys 
        35                  40                  45              


Lys Thr Ile Trp Gln Glu Ser Arg Lys Val Met Arg Thr Pro Glu Ser 
    50                  55                  60                  


Gln Leu Phe Ser Ile Glu Asp Ile Gln Glu Val Arg Met Gly His Arg 
65                  70                  75                  80  


Thr Glu Gly Leu Glu Lys Phe Ala Arg Asp Val Pro Glu Asp Arg Cys 
                85                  90                  95      


Phe Ser Ile Val Phe Lys Asp Gln Arg Asn Thr Leu Asp Leu Ile Ala 
            100                 105                 110         


Pro Ser Pro Ala Asp Ala Gln His Trp Val Leu Gly Leu His Lys Ile 
        115                 120                 125             


Ile His His Ser Gly Ser Met Asp Gln Arg Gln Lys Leu Gln His Trp 
    130                 135                 140                 


Ile His Ser Cys Leu Arg Lys Ala Asp Lys Asn Lys Asp Asn Lys Met 
145                 150                 155                 160 


Ser Phe Lys Glu Leu Gln Asn Phe Leu Lys Gly Gly Gly Gly Ser Met 
                165                 170                 175     


Pro Lys Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asp Arg Thr 
            180                 185                 190         


Ile Leu Tyr Ile Lys Pro Gly Gly Tyr His Glu Phe Tyr Lys Ser Phe 
        195                 200                 205             


Asn Ile Met Lys Asn Ile Trp Ile Ile Pro Glu Arg Asn Val Ile Gly 
    210                 215                 220                 


Thr Thr Pro Gln Asp Phe His Pro Pro Thr Ser Leu Lys Asn Gly Asp 
225                 230                 235                 240 


Ser Ser Tyr Tyr Asp Pro Asn Tyr Leu Gln Ser Asp Glu Glu Lys Asp 
                245                 250                 255     


Arg Phe Leu Lys Ile Val Thr Lys Ile Phe Asn Arg Ile Asn Asn Asn 
            260                 265                 270         


Leu Ala Gly Ser Ile Leu Leu Glu Glu Leu Ser Lys Ala Asn Pro Tyr 
        275                 280                 285             


Leu Gly Asn Asp Asp Thr Pro Asp Asn Gln Phe His Ile Gly Asp Ala 
    290                 295                 300                 


Ser Ala Val Glu Ile Lys Phe Ser Asn Gly Ser Gln His Ile Leu Leu 
305                 310                 315                 320 


Pro Asn Val Ile Ile Met Gly Ala Glu Pro Asn Leu Phe Leu Thr Tyr 
                325                 330                 335     


Gln Arg Asn Ile Ser Ala Arg Asn Asn Tyr Lys Pro Ser Asn His Gly 
            340                 345                 350         


Phe Gly Ser Ile Ala Ile Val Thr Phe Ser Pro Glu Tyr Ser Phe Arg 
        355                 360                 365             


Phe Asn Asp Asn Ser Ile Asn Glu Phe Ile Gln Asp Pro Ala Leu Thr 
    370                 375                 380                 


Leu Met His Glu Leu Ile His Ser Leu His Gly Leu Tyr Gly Ala Lys 
385                 390                 395                 400 


Gly Ile Thr Thr Thr Cys Thr Ile Thr Gln Gln Gln Asn Pro Leu Ile 
                405                 410                 415     


Thr Asn Arg Lys Gly Ile Lys Ile Glu Glu Phe Leu Thr Phe Gly Gly 
            420                 425                 430         


Asn Asp Leu Asn Ile Ile Thr Val Ala Gln Tyr Asn Asp Ile Tyr Thr 
        435                 440                 445             


Asn Leu Leu Asn Asp Tyr Arg Lys Ile Ala Ser Lys Leu Ser Lys Val 
    450                 455                 460                 


Gln Val Ser Asn Pro Gln Leu Asn Pro Tyr Lys Asp Ile Phe Gln Glu 
465                 470                 475                 480 


Lys Tyr Gly Leu Asp Lys Asp Ala Ser Gly Ile Tyr Ser Val Asn Ile 
                485                 490                 495     


Asn Lys Phe Asp Asp Ile Leu Lys Lys Leu Tyr Ser Phe Thr Glu Phe 
            500                 505                 510         


Asp Leu Ala Thr Lys Phe Gln Val Lys Cys Arg Glu Thr Tyr Ile Gly 
        515                 520                 525             


Arg Pro Lys Phe Phe Lys Leu Ser Asn Leu Leu Asn Asp Ser Ile Tyr 
    530                 535                 540                 


Asn Ile Ser Glu Gly Tyr Asn Ile Asn Asn Leu Lys Val Asn Phe Arg 
545                 550                 555                 560 


Gly Gln Asn Ala Asn Leu Asn Pro Arg Ile Ile Lys Pro Ile Thr Gly 
                565                 570                 575     


Arg Gly Leu Val Lys Lys Ile Ile Arg Phe 
            580                 585     


<210>  7
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Ala Thr Gly Gly Ala Cys Thr Cys Gly Gly Gly Cys Cys Gly Gly Gly 
1               5                   10                  15      


Ala Cys Thr Thr Cys Cys Thr Gly Ala Cys Cys Cys Thr Gly Cys Ala 
            20                  25                  30          


Cys Gly Gly Cys Cys Thr Ala Cys Ala Gly Gly Ala Thr Gly Ala Thr 
        35                  40                  45              


Gly Ala Gly Gly Ala Thr Cys Thr Ala Cys Ala Gly Gly Cys Gly Cys 
    50                  55                  60                  


Thr Gly Cys Thr Gly Ala Ala Gly Gly Gly Cys Ala Gly Cys Cys Ala 
65                  70                  75                  80  


Gly Cys Thr Cys Cys Thr Gly Ala Ala Gly Gly Thr Gly Ala Ala Gly 
                85                  90                  95      


Thr Cys Cys Ala Gly Cys Thr Cys Ala Thr Gly Gly Ala Gly Gly Ala 
            100                 105                 110         


Gly Ala Gly Ala Gly Cys Gly Cys Thr Thr Cys Thr Ala Cys Ala Ala 
        115                 120                 125             


Gly Thr Thr Gly Cys Ala Gly Gly Ala Gly Gly Ala Cys Thr Gly Cys 
    130                 135                 140                 


Ala Ala Gly Ala Cys Cys Ala Thr Cys Thr Gly Gly Cys Ala Gly Gly 
145                 150                 155                 160 


Ala Gly Thr Cys Cys Cys Gly Cys Ala Ala Gly Gly Thr Cys Ala Thr 
                165                 170                 175     


Gly Cys Gly Gly Ala Cys Cys Cys Cys Gly Gly Ala Gly Thr Cys Cys 
            180                 185                 190         


Cys Ala Gly Cys Thr Gly Thr Thr Cys Thr Cys Cys Ala Thr Cys Gly 
        195                 200                 205             


Ala Gly Gly Ala Cys Ala Thr Thr Cys Ala Gly Gly Ala Gly Gly Thr 
    210                 215                 220                 


Gly Cys Gly Ala Ala Thr Gly Gly Gly Gly Cys Ala Cys Cys Gly Cys 
225                 230                 235                 240 


Ala Cys Gly Gly Ala Gly Gly Gly Thr Cys Thr Gly Gly Ala Gly Ala 
                245                 250                 255     


Ala Gly Thr Thr Cys Gly Cys Cys Cys Gly Thr Gly Ala Thr Gly Thr 
            260                 265                 270         


Gly Cys Cys Cys Gly Ala Gly Gly Ala Cys Cys Gly Cys Thr Gly Cys 
        275                 280                 285             


Thr Thr Cys Thr Cys Cys Ala Thr Thr Gly Thr Cys Thr Thr Cys Ala 
    290                 295                 300                 


Ala Gly Gly Ala Cys Cys Ala Gly Cys Gly Cys Ala Ala Thr Ala Cys 
305                 310                 315                 320 


Ala Cys Thr Ala Gly Ala Cys Cys Thr Cys Ala Thr Cys Gly Cys Cys 
                325                 330                 335     


Cys Cys Ala Thr Cys Gly Cys Cys Ala Gly Cys Thr Gly Ala Thr Gly 
            340                 345                 350         


Cys Cys Cys Ala Gly Cys Ala Cys Thr Gly Gly Gly Thr Gly Cys Thr 
        355                 360                 365             


Gly Gly Gly Gly Cys Thr Gly Cys Ala Cys Ala Ala Gly Ala Thr Cys 
    370                 375                 380                 


Ala Thr Cys Cys Ala Cys Cys Ala Cys Thr Cys Ala Gly Gly Cys Thr 
385                 390                 395                 400 


Cys Cys Ala Thr Gly Gly Ala Cys Cys Ala Gly Cys Gly Thr Cys Ala 
                405                 410                 415     


Gly Ala Ala Gly Cys Thr Ala Cys Ala Gly Cys Ala Cys Thr Gly Gly 
            420                 425                 430         


Ala Thr Thr Cys Ala Cys Thr Cys Cys Thr Gly Cys Thr Thr Gly Cys 
        435                 440                 445             


Gly Ala Ala Ala Ala Gly Cys Thr Gly Ala Cys Ala Ala Ala Ala Ala 
    450                 455                 460                 


Cys Ala Ala Gly Gly Ala Cys Ala Ala Cys Ala Ala Gly Ala Thr Gly 
465                 470                 475                 480 


Ala Gly Cys Thr Thr Cys Ala Ala Gly Gly Ala Gly Cys Thr Gly Cys 
                485                 490                 495     


Ala Gly Ala Ala Cys Thr Thr Cys Cys Thr Gly Ala Ala Gly 
            500                 505                 510 


<210>  8
<211>  1233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Ala Thr Gly Cys Cys Ala Ala Ala Ala Ala Thr Cys Ala Ala Cys Ala 
1               5                   10                  15      


Gly Cys Thr Thr Thr Ala Ala Thr Thr Ala Cys Ala Ala Thr Gly Ala 
            20                  25                  30          


Cys Cys Cys Thr Gly Thr Ala Ala Ala Cys Gly Ala Thr Cys Gly Thr 
        35                  40                  45              


Ala Cys Cys Ala Thr Cys Cys Thr Ala Thr Ala Cys Ala Thr Ala Ala 
    50                  55                  60                  


Ala Gly Cys Cys Gly Gly Gly Thr Gly Gly Gly Thr Ala Thr Cys Ala 
65                  70                  75                  80  


Cys Gly Ala Gly Thr Thr Cys Thr Ala Cys Ala Ala Ala Thr Cys Thr 
                85                  90                  95      


Thr Thr Cys Ala Ala Thr Ala Thr Thr Ala Thr Gly Ala Ala Gly Ala 
            100                 105                 110         


Ala Thr Ala Thr Ala Thr Gly Gly Ala Thr Thr Ala Thr Ala Cys Cys 
        115                 120                 125             


Thr Gly Ala Gly Cys Gly Thr Ala Ala Cys Gly Thr Thr Ala Thr Thr 
    130                 135                 140                 


Gly Gly Thr Ala Cys Gly Ala Cys Ala Cys Cys Gly Cys Ala Ala Gly 
145                 150                 155                 160 


Ala Thr Thr Thr Thr Cys Ala Thr Cys Cys Ala Cys Cys Thr Ala Cys 
                165                 170                 175     


Thr Thr Cys Gly Thr Thr Gly Ala Ala Gly Ala Ala Cys Gly Gly Thr 
            180                 185                 190         


Gly Ala Cys Thr Cys Thr Thr Cys Cys Thr Ala Thr Thr Ala Cys Gly 
        195                 200                 205             


Ala Cys Cys Cys Cys Ala Ala Thr Thr Ala Thr Cys Thr Cys Cys Ala 
    210                 215                 220                 


Gly Thr Cys Gly Gly Ala Thr Gly Ala Ala Gly Ala Gly Ala Ala Gly 
225                 230                 235                 240 


Gly Ala Cys Ala Gly Ala Thr Thr Cys Cys Thr Thr Ala Ala Ala Ala 
                245                 250                 255     


Thr Ala Gly Thr Ala Ala Cys Cys Ala Ala Ala Ala Thr Cys Thr Thr 
            260                 265                 270         


Thr Ala Ala Cys Ala Gly Gly Ala Thr Thr Ala Ala Thr Ala Ala Cys 
        275                 280                 285             


Ala Ala Thr Cys Thr Ala Gly Cys Cys Gly Gly Ala Ala Gly Thr Ala 
    290                 295                 300                 


Thr Thr Thr Thr Gly Cys Thr Thr Gly Ala Ala Gly Ala Gly Cys Thr 
305                 310                 315                 320 


Thr Ala Gly Thr Ala Ala Ala Gly Cys Thr Ala Ala Thr Cys Cys Thr 
                325                 330                 335     


Thr Ala Cys Cys Thr Ala Gly Gly Thr Ala Ala Cys Gly Ala Thr Gly 
            340                 345                 350         


Ala Thr Ala Cys Ala Cys Cys Ala Gly Ala Cys Ala Ala Cys Cys Ala 
        355                 360                 365             


Gly Thr Thr Thr Cys Ala Thr Ala Thr Ala Gly Gly Cys Gly Ala Thr 
    370                 375                 380                 


Gly Cys Ala Thr Cys Cys Gly Cys Cys Gly Thr Gly Gly Ala Ala Ala 
385                 390                 395                 400 


Thr Cys Ala Ala Ala Thr Thr Thr Ala Gly Cys Ala Ala Thr Gly Gly 
                405                 410                 415     


Ala Thr Cys Ala Cys Ala Gly Cys Ala Thr Ala Thr Thr Cys Thr Cys 
            420                 425                 430         


Thr Thr Gly Cys Cys Cys Ala Ala Cys Gly Thr Thr Ala Thr Thr Ala 
        435                 440                 445             


Thr Ala Ala Thr Gly Gly Gly Gly Gly Cys Gly Gly Ala Ala Cys Cys 
    450                 455                 460                 


Ala Ala Ala Thr Thr Thr Ala Thr Thr Thr Thr Thr Gly Ala Cys Ala 
465                 470                 475                 480 


Thr Ala Thr Cys Ala Gly Ala Gly Ala Ala Ala Thr Ala Thr Thr Ala 
                485                 490                 495     


Gly Cys Cys Thr Gly Ala Gly Ala Ala Ala Thr Ala Ala Cys Thr Ala 
            500                 505                 510         


Thr Ala Ala Gly Cys Cys Gly Thr Cys Ala Ala Ala Cys Cys Ala Thr 
        515                 520                 525             


Gly Gly Gly Thr Thr Cys Gly Gly Thr Ala Gly Cys Ala Thr Ala Gly 
    530                 535                 540                 


Cys Ala Ala Thr Cys Gly Thr Thr Ala Cys Thr Thr Thr Thr Thr Cys 
545                 550                 555                 560 


Thr Cys Cys Cys Gly Ala Ala Thr Ala Cys Ala Gly Thr Thr Thr Thr 
                565                 570                 575     


Cys Gly Cys Thr Thr Cys Ala Ala Thr Gly Ala Thr Ala Ala Thr Ala 
            580                 585                 590         


Gly Thr Ala Thr Ala Ala Ala Thr Gly Ala Gly Thr Thr Thr Ala Thr 
        595                 600                 605             


Cys Cys Ala Ala Gly Ala Cys Cys Cys Cys Gly Cys Ala Cys Thr Cys 
    610                 615                 620                 


Ala Cys Gly Cys Thr Thr Ala Thr Gly Cys Ala Cys Gly Ala Ala Cys 
625                 630                 635                 640 


Thr Cys Ala Thr Ala Cys Ala Cys Thr Cys Thr Thr Thr Ala Cys Ala 
                645                 650                 655     


Cys Gly Gly Cys Cys Thr Gly Thr Ala Thr Gly Gly Cys Gly Cys Thr 
            660                 665                 670         


Ala Ala Gly Gly Gly Gly Ala Thr Ala Ala Cys Cys Ala Cys Thr Ala 
        675                 680                 685             


Cys Gly Thr Gly Thr Ala Cys Cys Ala Thr Thr Ala Cys Thr Cys Ala 
    690                 695                 700                 


Gly Cys Ala Ala Cys Ala Gly Ala Ala Cys Cys Cys Ala Thr Thr Gly 
705                 710                 715                 720 


Ala Thr Ala Ala Cys Gly Ala Ala Cys Ala Gly Gly Ala Ala Gly Gly 
                725                 730                 735     


Gly Cys Ala Thr Thr Ala Ala Ala Ala Thr Cys Gly Ala Gly Gly Ala 
            740                 745                 750         


Ala Thr Thr Thr Cys Thr Thr Ala Cys Ala Thr Thr Thr Gly Gly Ala 
        755                 760                 765             


Gly Gly Cys Ala Ala Cys Gly Ala Thr Cys Thr Gly Ala Ala Cys Ala 
    770                 775                 780                 


Thr Thr Ala Thr Ala Ala Cys Thr Gly Thr Cys Gly Cys Ala Cys Ala 
785                 790                 795                 800 


Gly Thr Ala Cys Ala Ala Thr Gly Ala Cys Ala Thr Cys Thr Ala Thr 
                805                 810                 815     


Ala Cys Cys Ala Ala Cys Thr Thr Ala Cys Thr Ala Ala Ala Thr Gly 
            820                 825                 830         


Ala Thr Thr Ala Thr Ala Gly Ala Ala Ala Ala Ala Thr Cys Gly Cys 
        835                 840                 845             


Thr Thr Cys Thr Ala Ala Gly Thr Thr Ala Thr Cys Cys Ala Ala Gly 
    850                 855                 860                 


Gly Thr Thr Cys Ala Ala Gly Thr Cys Thr Cys Ala Ala Ala Cys Cys 
865                 870                 875                 880 


Cys Thr Cys Ala Ala Cys Thr Gly Ala Ala Thr Cys Cys Gly Thr Ala 
                885                 890                 895     


Thr Ala Ala Gly Gly Ala Cys Ala Thr Ala Thr Thr Cys Cys Ala Ala 
            900                 905                 910         


Gly Ala Ala Ala Ala Ala Thr Ala Thr Gly Gly Ala Thr Thr Ala Gly 
        915                 920                 925             


Ala Cys Ala Ala Ala Gly Ala Cys Gly Cys Gly Thr Cys Ala Gly Gly 
    930                 935                 940                 


Ala Ala Thr Cys Thr Ala Thr Thr Cys Gly Gly Thr Ala Ala Ala Cys 
945                 950                 955                 960 


Ala Thr Thr Ala Ala Cys Ala Ala Ala Thr Thr Cys Gly Ala Cys Gly 
                965                 970                 975     


Ala Thr Ala Thr Thr Thr Thr Gly Ala Ala Gly Ala Ala Ala Cys Thr 
            980                 985                 990         


Thr Thr Ala Cys Ala Gly Cys Thr  Thr Cys Ala Cys Gly  Gly Ala Gly 
        995                 1000                 1005             


Thr Thr  Cys Gly Ala Cys Thr  Thr Gly Gly Cys Cys  Ala Cys Cys 
    1010                 1015                 1020             


Ala Ala  Ala Thr Thr Cys Cys  Ala Gly Gly Thr Cys  Ala Ala Ala 
    1025                 1030                 1035             


Thr Gly  Cys Cys Gly Ala Gly  Ala Gly Ala Cys Ala  Thr Ala Cys 
    1040                 1045                 1050             


Ala Thr  Cys Gly Gly Ala Cys  Gly Gly Cys Cys Thr  Ala Ala Gly 
    1055                 1060                 1065             


Thr Thr  Thr Thr Thr Thr Ala  Ala Gly Cys Thr Gly  Thr Cys Gly 
    1070                 1075                 1080             


Ala Ala  Thr Cys Thr Cys Cys  Thr Gly Ala Ala Thr  Gly Ala Thr 
    1085                 1090                 1095             


Thr Cys  Cys Ala Thr Ala Thr  Ala Cys Ala Ala Cys  Ala Thr Thr 
    1100                 1105                 1110             


Ala Gly  Thr Gly Ala Gly Gly  Gly Thr Thr Ala Cys  Ala Ala Thr 
    1115                 1120                 1125             


Ala Thr  Ala Ala Ala Thr Ala  Ala Cys Cys Thr Ala  Ala Ala Gly 
    1130                 1135                 1140             


Gly Thr  Gly Ala Ala Thr Thr  Thr Cys Cys Gly Ala  Gly Gly Cys 
    1145                 1150                 1155             


Cys Ala  Ala Ala Ala Cys Gly  Cys Cys Ala Ala Cys  Cys Thr Ala 
    1160                 1165                 1170             


Ala Ala  Thr Cys Cys Gly Cys  Gly Thr Ala Thr Cys  Ala Thr Thr 
    1175                 1180                 1185             


Ala Ala  Ala Cys Cys Cys Ala  Thr Cys Ala Cys Ala  Gly Gly Ala 
    1190                 1195                 1200             


Cys Gly  Gly Gly Gly Gly Thr  Thr Ala Gly Thr Gly  Ala Ala Gly 
    1205                 1210                 1215             


Ala Ala  Ala Ala Thr Ala Ala  Thr Cys Cys Gly Gly  Thr Thr Thr 
    1220                 1225                 1230             


<210>  9
<211>  1233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Ala Thr Gly Cys Cys Ala Ala Ala Ala Ala Thr Cys Ala Ala Cys Ala 
1               5                   10                  15      


Gly Cys Thr Thr Thr Ala Ala Thr Thr Ala Cys Ala Ala Thr Gly Ala 
            20                  25                  30          


Cys Cys Cys Thr Gly Thr Ala Ala Ala Cys Gly Ala Thr Cys Gly Thr 
        35                  40                  45              


Ala Cys Cys Ala Thr Cys Cys Thr Ala Thr Ala Cys Ala Thr Ala Ala 
    50                  55                  60                  


Ala Gly Cys Cys Gly Gly Gly Thr Gly Gly Gly Thr Ala Thr Cys Ala 
65                  70                  75                  80  


Cys Gly Ala Gly Thr Thr Cys Thr Ala Cys Ala Ala Ala Thr Cys Thr 
                85                  90                  95      


Thr Thr Cys Ala Ala Thr Ala Thr Thr Ala Thr Gly Ala Ala Gly Ala 
            100                 105                 110         


Ala Thr Ala Thr Ala Thr Gly Gly Ala Thr Thr Ala Thr Ala Cys Cys 
        115                 120                 125             


Thr Gly Ala Gly Cys Gly Thr Ala Ala Cys Gly Thr Thr Ala Thr Thr 
    130                 135                 140                 


Gly Gly Thr Ala Cys Gly Ala Cys Ala Cys Cys Gly Cys Ala Ala Gly 
145                 150                 155                 160 


Ala Thr Thr Thr Thr Cys Ala Thr Cys Cys Ala Cys Cys Thr Ala Cys 
                165                 170                 175     


Thr Thr Cys Gly Thr Thr Gly Ala Ala Gly Ala Ala Cys Gly Gly Thr 
            180                 185                 190         


Gly Ala Cys Thr Cys Thr Thr Cys Cys Thr Ala Thr Thr Ala Cys Gly 
        195                 200                 205             


Ala Cys Cys Cys Cys Ala Ala Thr Thr Ala Thr Cys Thr Cys Cys Ala 
    210                 215                 220                 


Gly Thr Cys Gly Gly Ala Thr Gly Ala Ala Gly Ala Gly Ala Ala Gly 
225                 230                 235                 240 


Gly Ala Cys Ala Gly Ala Thr Thr Cys Cys Thr Thr Ala Ala Ala Ala 
                245                 250                 255     


Thr Ala Gly Thr Ala Ala Cys Cys Ala Ala Ala Ala Thr Cys Thr Thr 
            260                 265                 270         


Thr Ala Ala Cys Ala Gly Gly Ala Thr Thr Ala Ala Thr Ala Ala Cys 
        275                 280                 285             


Ala Ala Thr Cys Thr Ala Gly Cys Cys Gly Gly Ala Ala Gly Thr Ala 
    290                 295                 300                 


Thr Thr Thr Thr Gly Cys Thr Thr Gly Ala Ala Gly Ala Gly Cys Thr 
305                 310                 315                 320 


Thr Ala Gly Thr Ala Ala Ala Gly Cys Thr Ala Ala Thr Cys Cys Thr 
                325                 330                 335     


Thr Ala Cys Cys Thr Ala Gly Gly Thr Ala Ala Cys Gly Ala Thr Gly 
            340                 345                 350         


Ala Thr Ala Cys Ala Cys Cys Ala Gly Ala Cys Ala Ala Cys Cys Ala 
        355                 360                 365             


Gly Thr Thr Thr Cys Ala Thr Ala Thr Ala Gly Gly Cys Gly Ala Thr 
    370                 375                 380                 


Gly Cys Ala Thr Cys Cys Gly Cys Cys Gly Thr Gly Gly Ala Ala Ala 
385                 390                 395                 400 


Thr Cys Ala Ala Ala Thr Thr Thr Ala Gly Cys Ala Ala Thr Gly Gly 
                405                 410                 415     


Ala Thr Cys Ala Cys Ala Gly Cys Ala Thr Ala Thr Thr Cys Thr Cys 
            420                 425                 430         


Thr Thr Gly Cys Cys Cys Ala Ala Cys Gly Thr Thr Ala Thr Thr Ala 
        435                 440                 445             


Thr Ala Ala Thr Gly Gly Gly Gly Gly Cys Gly Gly Ala Ala Cys Cys 
    450                 455                 460                 


Ala Ala Ala Thr Thr Thr Ala Thr Thr Thr Thr Thr Gly Ala Cys Ala 
465                 470                 475                 480 


Thr Ala Thr Cys Ala Gly Ala Gly Ala Ala Ala Thr Ala Thr Thr Ala 
                485                 490                 495     


Gly Cys Gly Cys Cys Ala Gly Ala Ala Ala Thr Ala Ala Cys Thr Ala 
            500                 505                 510         


Thr Ala Ala Gly Cys Cys Gly Thr Cys Ala Ala Ala Cys Cys Ala Thr 
        515                 520                 525             


Gly Gly Gly Thr Thr Cys Gly Gly Thr Ala Gly Cys Ala Thr Ala Gly 
    530                 535                 540                 


Cys Ala Ala Thr Cys Gly Thr Thr Ala Cys Thr Thr Thr Thr Thr Cys 
545                 550                 555                 560 


Thr Cys Cys Cys Gly Ala Ala Thr Ala Cys Ala Gly Thr Thr Thr Thr 
                565                 570                 575     


Cys Gly Cys Thr Thr Cys Ala Ala Thr Gly Ala Thr Ala Ala Thr Ala 
            580                 585                 590         


Gly Thr Ala Thr Ala Ala Ala Thr Gly Ala Gly Thr Thr Thr Ala Thr 
        595                 600                 605             


Cys Cys Ala Ala Gly Ala Cys Cys Cys Cys Gly Cys Ala Cys Thr Cys 
    610                 615                 620                 


Ala Cys Gly Cys Thr Thr Ala Thr Gly Cys Ala Cys Gly Ala Ala Cys 
625                 630                 635                 640 


Thr Cys Ala Thr Ala Cys Ala Cys Thr Cys Thr Thr Thr Ala Cys Ala 
                645                 650                 655     


Cys Gly Gly Cys Cys Thr Gly Thr Ala Thr Gly Gly Cys Gly Cys Thr 
            660                 665                 670         


Ala Ala Gly Gly Gly Gly Ala Thr Ala Ala Cys Cys Ala Cys Thr Ala 
        675                 680                 685             


Cys Gly Thr Gly Thr Ala Cys Cys Ala Thr Thr Ala Cys Thr Cys Ala 
    690                 695                 700                 


Gly Cys Ala Ala Cys Ala Gly Ala Ala Cys Cys Cys Ala Thr Thr Gly 
705                 710                 715                 720 


Ala Thr Ala Ala Cys Gly Ala Ala Cys Ala Gly Gly Ala Ala Gly Gly 
                725                 730                 735     


Gly Cys Ala Thr Thr Ala Ala Ala Ala Thr Cys Gly Ala Gly Gly Ala 
            740                 745                 750         


Ala Thr Thr Thr Cys Thr Thr Ala Cys Ala Thr Thr Thr Gly Gly Ala 
        755                 760                 765             


Gly Gly Cys Ala Ala Cys Gly Ala Thr Cys Thr Gly Ala Ala Cys Ala 
    770                 775                 780                 


Thr Thr Ala Thr Ala Ala Cys Thr Gly Thr Cys Gly Cys Ala Cys Ala 
785                 790                 795                 800 


Gly Thr Ala Cys Ala Ala Thr Gly Ala Cys Ala Thr Cys Thr Ala Thr 
                805                 810                 815     


Ala Cys Cys Ala Ala Cys Thr Thr Ala Cys Thr Ala Ala Ala Thr Gly 
            820                 825                 830         


Ala Thr Thr Ala Thr Ala Gly Ala Ala Ala Ala Ala Thr Cys Gly Cys 
        835                 840                 845             


Thr Thr Cys Thr Ala Ala Gly Thr Thr Ala Thr Cys Cys Ala Ala Gly 
    850                 855                 860                 


Gly Thr Thr Cys Ala Ala Gly Thr Cys Thr Cys Ala Ala Ala Cys Cys 
865                 870                 875                 880 


Cys Thr Cys Ala Ala Cys Thr Gly Ala Ala Thr Cys Cys Gly Thr Ala 
                885                 890                 895     


Thr Ala Ala Gly Gly Ala Cys Ala Thr Ala Thr Thr Cys Cys Ala Ala 
            900                 905                 910         


Gly Ala Ala Ala Ala Ala Thr Ala Thr Gly Gly Ala Thr Thr Ala Gly 
        915                 920                 925             


Ala Cys Ala Ala Ala Gly Ala Cys Gly Cys Gly Thr Cys Ala Gly Gly 
    930                 935                 940                 


Ala Ala Thr Cys Thr Ala Thr Thr Cys Gly Gly Thr Ala Ala Ala Cys 
945                 950                 955                 960 


Ala Thr Thr Ala Ala Cys Ala Ala Ala Thr Thr Cys Gly Ala Cys Gly 
                965                 970                 975     


Ala Thr Ala Thr Thr Thr Thr Gly Ala Ala Gly Ala Ala Ala Cys Thr 
            980                 985                 990         


Thr Thr Ala Cys Ala Gly Cys Thr  Thr Cys Ala Cys Gly  Gly Ala Gly 
        995                 1000                 1005             


Thr Thr  Cys Gly Ala Cys Thr  Thr Gly Gly Cys Cys  Ala Cys Cys 
    1010                 1015                 1020             


Ala Ala  Ala Thr Thr Cys Cys  Ala Gly Gly Thr Cys  Ala Ala Ala 
    1025                 1030                 1035             


Thr Gly  Cys Cys Gly Ala Gly  Ala Gly Ala Cys Ala  Thr Ala Cys 
    1040                 1045                 1050             


Ala Thr  Cys Gly Gly Ala Cys  Gly Gly Cys Cys Thr  Ala Ala Gly 
    1055                 1060                 1065             


Thr Thr  Thr Thr Thr Thr Ala  Ala Gly Cys Thr Gly  Thr Cys Gly 
    1070                 1075                 1080             


Ala Ala  Thr Cys Thr Cys Cys  Thr Gly Ala Ala Thr  Gly Ala Thr 
    1085                 1090                 1095             


Thr Cys  Cys Ala Thr Ala Thr  Ala Cys Ala Ala Cys  Ala Thr Thr 
    1100                 1105                 1110             


Ala Gly  Thr Gly Ala Gly Gly  Gly Thr Thr Ala Cys  Ala Ala Thr 
    1115                 1120                 1125             


Ala Thr  Ala Ala Ala Thr Ala  Ala Cys Cys Thr Ala  Ala Ala Gly 
    1130                 1135                 1140             


Gly Thr  Gly Ala Ala Thr Thr  Thr Cys Cys Gly Ala  Gly Gly Cys 
    1145                 1150                 1155             


Cys Ala  Ala Ala Ala Cys Gly  Cys Cys Ala Ala Cys  Cys Thr Ala 
    1160                 1165                 1170             


Ala Ala  Thr Cys Cys Gly Cys  Gly Thr Ala Thr Cys  Ala Thr Thr 
    1175                 1180                 1185             


Ala Ala  Ala Cys Cys Cys Ala  Thr Cys Ala Cys Ala  Gly Gly Ala 
    1190                 1195                 1200             


Cys Gly  Gly Gly Gly Gly Thr  Thr Ala Gly Thr Gly  Ala Ala Gly 
    1205                 1210                 1215             


Ala Ala  Ala Ala Thr Ala Ala  Thr Cys Cys Gly Gly  Thr Thr Thr 
    1220                 1225                 1230             


<210>  10
<211>  1758
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Ala Thr Gly Gly Ala Cys Thr Cys Gly Gly Gly Cys Cys Gly Gly Gly 
1               5                   10                  15      


Ala Cys Thr Thr Cys Cys Thr Gly Ala Cys Cys Cys Thr Gly Cys Ala 
            20                  25                  30          


Cys Gly Gly Cys Cys Thr Ala Cys Ala Gly Gly Ala Thr Gly Ala Thr 
        35                  40                  45              


Gly Ala Gly Gly Ala Thr Cys Thr Ala Cys Ala Gly Gly Cys Gly Cys 
    50                  55                  60                  


Thr Gly Cys Thr Gly Ala Ala Gly Gly Gly Cys Ala Gly Cys Cys Ala 
65                  70                  75                  80  


Gly Cys Thr Cys Cys Thr Gly Ala Ala Gly Gly Thr Gly Ala Ala Gly 
                85                  90                  95      


Thr Cys Cys Ala Gly Cys Thr Cys Ala Thr Gly Gly Ala Gly Gly Ala 
            100                 105                 110         


Gly Ala Gly Ala Gly Cys Gly Cys Thr Thr Cys Thr Ala Cys Ala Ala 
        115                 120                 125             


Gly Thr Thr Gly Cys Ala Gly Gly Ala Gly Gly Ala Cys Thr Gly Cys 
    130                 135                 140                 


Ala Ala Gly Ala Cys Cys Ala Thr Cys Thr Gly Gly Cys Ala Gly Gly 
145                 150                 155                 160 


Ala Gly Thr Cys Cys Cys Gly Cys Ala Ala Gly Gly Thr Cys Ala Thr 
                165                 170                 175     


Gly Cys Gly Gly Ala Cys Cys Cys Cys Gly Gly Ala Gly Thr Cys Cys 
            180                 185                 190         


Cys Ala Gly Cys Thr Gly Thr Thr Cys Thr Cys Cys Ala Thr Cys Gly 
        195                 200                 205             


Ala Gly Gly Ala Cys Ala Thr Thr Cys Ala Gly Gly Ala Gly Gly Thr 
    210                 215                 220                 


Gly Cys Gly Ala Ala Thr Gly Gly Gly Gly Cys Ala Cys Cys Gly Cys 
225                 230                 235                 240 


Ala Cys Gly Gly Ala Gly Gly Gly Thr Cys Thr Gly Gly Ala Gly Ala 
                245                 250                 255     


Ala Gly Thr Thr Cys Gly Cys Cys Cys Gly Thr Gly Ala Thr Gly Thr 
            260                 265                 270         


Gly Cys Cys Cys Gly Ala Gly Gly Ala Cys Cys Gly Cys Thr Gly Cys 
        275                 280                 285             


Thr Thr Cys Thr Cys Cys Ala Thr Thr Gly Thr Cys Thr Thr Cys Ala 
    290                 295                 300                 


Ala Gly Gly Ala Cys Cys Ala Gly Cys Gly Cys Ala Ala Thr Ala Cys 
305                 310                 315                 320 


Ala Cys Thr Ala Gly Ala Cys Cys Thr Cys Ala Thr Cys Gly Cys Cys 
                325                 330                 335     


Cys Cys Ala Thr Cys Gly Cys Cys Ala Gly Cys Thr Gly Ala Thr Gly 
            340                 345                 350         


Cys Cys Cys Ala Gly Cys Ala Cys Thr Gly Gly Gly Thr Gly Cys Thr 
        355                 360                 365             


Gly Gly Gly Gly Cys Thr Gly Cys Ala Cys Ala Ala Gly Ala Thr Cys 
    370                 375                 380                 


Ala Thr Cys Cys Ala Cys Cys Ala Cys Thr Cys Ala Gly Gly Cys Thr 
385                 390                 395                 400 


Cys Cys Ala Thr Gly Gly Ala Cys Cys Ala Gly Cys Gly Thr Cys Ala 
                405                 410                 415     


Gly Ala Ala Gly Cys Thr Ala Cys Ala Gly Cys Ala Cys Thr Gly Gly 
            420                 425                 430         


Ala Thr Thr Cys Ala Cys Thr Cys Cys Thr Gly Cys Thr Thr Gly Cys 
        435                 440                 445             


Gly Ala Ala Ala Ala Gly Cys Thr Gly Ala Cys Ala Ala Ala Ala Ala 
    450                 455                 460                 


Cys Ala Ala Gly Gly Ala Cys Ala Ala Cys Ala Ala Gly Ala Thr Gly 
465                 470                 475                 480 


Ala Gly Cys Thr Thr Cys Ala Ala Gly Gly Ala Gly Cys Thr Gly Cys 
                485                 490                 495     


Ala Gly Ala Ala Cys Thr Thr Cys Cys Thr Gly Ala Ala Gly Gly Gly 
            500                 505                 510         


Thr Gly Gly Thr Gly Gly Thr Gly Gly Thr Ala Gly Cys Ala Thr Gly 
        515                 520                 525             


Cys Cys Ala Ala Ala Ala Ala Thr Cys Ala Ala Cys Ala Gly Cys Thr 
    530                 535                 540                 


Thr Thr Ala Ala Thr Thr Ala Cys Ala Ala Thr Gly Ala Cys Cys Cys 
545                 550                 555                 560 


Thr Gly Thr Ala Ala Ala Cys Gly Ala Thr Cys Gly Thr Ala Cys Cys 
                565                 570                 575     


Ala Thr Cys Cys Thr Ala Thr Ala Cys Ala Thr Ala Ala Ala Gly Cys 
            580                 585                 590         


Cys Gly Gly Gly Thr Gly Gly Gly Thr Ala Thr Cys Ala Cys Gly Ala 
        595                 600                 605             


Gly Thr Thr Cys Thr Ala Cys Ala Ala Ala Thr Cys Thr Thr Thr Cys 
    610                 615                 620                 


Ala Ala Thr Ala Thr Thr Ala Thr Gly Ala Ala Gly Ala Ala Thr Ala 
625                 630                 635                 640 


Thr Ala Thr Gly Gly Ala Thr Thr Ala Thr Ala Cys Cys Thr Gly Ala 
                645                 650                 655     


Gly Cys Gly Thr Ala Ala Cys Gly Thr Thr Ala Thr Thr Gly Gly Thr 
            660                 665                 670         


Ala Cys Gly Ala Cys Ala Cys Cys Gly Cys Ala Ala Gly Ala Thr Thr 
        675                 680                 685             


Thr Thr Cys Ala Thr Cys Cys Ala Cys Cys Thr Ala Cys Thr Thr Cys 
    690                 695                 700                 


Gly Thr Thr Gly Ala Ala Gly Ala Ala Cys Gly Gly Thr Gly Ala Cys 
705                 710                 715                 720 


Thr Cys Thr Thr Cys Cys Thr Ala Thr Thr Ala Cys Gly Ala Cys Cys 
                725                 730                 735     


Cys Cys Ala Ala Thr Thr Ala Thr Cys Thr Cys Cys Ala Gly Thr Cys 
            740                 745                 750         


Gly Gly Ala Thr Gly Ala Ala Gly Ala Gly Ala Ala Gly Gly Ala Cys 
        755                 760                 765             


Ala Gly Ala Thr Thr Cys Cys Thr Thr Ala Ala Ala Ala Thr Ala Gly 
    770                 775                 780                 


Thr Ala Ala Cys Cys Ala Ala Ala Ala Thr Cys Thr Thr Thr Ala Ala 
785                 790                 795                 800 


Cys Ala Gly Gly Ala Thr Thr Ala Ala Thr Ala Ala Cys Ala Ala Thr 
                805                 810                 815     


Cys Thr Ala Gly Cys Cys Gly Gly Ala Ala Gly Thr Ala Thr Thr Thr 
            820                 825                 830         


Thr Gly Cys Thr Thr Gly Ala Ala Gly Ala Gly Cys Thr Thr Ala Gly 
        835                 840                 845             


Thr Ala Ala Ala Gly Cys Thr Ala Ala Thr Cys Cys Thr Thr Ala Cys 
    850                 855                 860                 


Cys Thr Ala Gly Gly Thr Ala Ala Cys Gly Ala Thr Gly Ala Thr Ala 
865                 870                 875                 880 


Cys Ala Cys Cys Ala Gly Ala Cys Ala Ala Cys Cys Ala Gly Thr Thr 
                885                 890                 895     


Thr Cys Ala Thr Ala Thr Ala Gly Gly Cys Gly Ala Thr Gly Cys Ala 
            900                 905                 910         


Thr Cys Cys Gly Cys Cys Gly Thr Gly Gly Ala Ala Ala Thr Cys Ala 
        915                 920                 925             


Ala Ala Thr Thr Thr Ala Gly Cys Ala Ala Thr Gly Gly Ala Thr Cys 
    930                 935                 940                 


Ala Cys Ala Gly Cys Ala Thr Ala Thr Thr Cys Thr Cys Thr Thr Gly 
945                 950                 955                 960 


Cys Cys Cys Ala Ala Cys Gly Thr Thr Ala Thr Thr Ala Thr Ala Ala 
                965                 970                 975     


Thr Gly Gly Gly Gly Gly Cys Gly Gly Ala Ala Cys Cys Ala Ala Ala 
            980                 985                 990         


Thr Thr Thr Ala Thr Thr Thr Thr  Thr Gly Ala Cys Ala  Thr Ala Thr 
        995                 1000                 1005             


Cys Ala  Gly Ala Gly Ala Ala  Ala Thr Ala Thr Thr  Ala Gly Cys 
    1010                 1015                 1020             


Cys Thr  Gly Ala Gly Ala Ala  Ala Thr Ala Ala Cys  Thr Ala Thr 
    1025                 1030                 1035             


Ala Ala  Gly Cys Cys Gly Thr  Cys Ala Ala Ala Cys  Cys Ala Thr 
    1040                 1045                 1050             


Gly Gly  Gly Thr Thr Cys Gly  Gly Thr Ala Gly Cys  Ala Thr Ala 
    1055                 1060                 1065             


Gly Cys  Ala Ala Thr Cys Gly  Thr Thr Ala Cys Thr  Thr Thr Thr 
    1070                 1075                 1080             


Thr Cys  Thr Cys Cys Cys Gly  Ala Ala Thr Ala Cys  Ala Gly Thr 
    1085                 1090                 1095             


Thr Thr  Thr Cys Gly Cys Thr  Thr Cys Ala Ala Thr  Gly Ala Thr 
    1100                 1105                 1110             


Ala Ala  Thr Ala Gly Thr Ala  Thr Ala Ala Ala Thr  Gly Ala Gly 
    1115                 1120                 1125             


Thr Thr  Thr Ala Thr Cys Cys  Ala Ala Gly Ala Cys  Cys Cys Cys 
    1130                 1135                 1140             


Gly Cys  Ala Cys Thr Cys Ala  Cys Gly Cys Thr Thr  Ala Thr Gly 
    1145                 1150                 1155             


Cys Ala  Cys Gly Ala Ala Cys  Thr Cys Ala Thr Ala  Cys Ala Cys 
    1160                 1165                 1170             


Thr Cys  Thr Thr Thr Ala Cys  Ala Cys Gly Gly Cys  Cys Thr Gly 
    1175                 1180                 1185             


Thr Ala  Thr Gly Gly Cys Gly  Cys Thr Ala Ala Gly  Gly Gly Gly 
    1190                 1195                 1200             


Ala Thr  Ala Ala Cys Cys Ala  Cys Thr Ala Cys Gly  Thr Gly Thr 
    1205                 1210                 1215             


Ala Cys  Cys Ala Thr Thr Ala  Cys Thr Cys Ala Gly  Cys Ala Ala 
    1220                 1225                 1230             


Cys Ala  Gly Ala Ala Cys Cys  Cys Ala Thr Thr Gly  Ala Thr Ala 
    1235                 1240                 1245             


Ala Cys  Gly Ala Ala Cys Ala  Gly Gly Ala Ala Gly  Gly Gly Cys 
    1250                 1255                 1260             


Ala Thr  Thr Ala Ala Ala Ala  Thr Cys Gly Ala Gly  Gly Ala Ala 
    1265                 1270                 1275             


Thr Thr  Thr Cys Thr Thr Ala  Cys Ala Thr Thr Thr  Gly Gly Ala 
    1280                 1285                 1290             


Gly Gly  Cys Ala Ala Cys Gly  Ala Thr Cys Thr Gly  Ala Ala Cys 
    1295                 1300                 1305             


Ala Thr  Thr Ala Thr Ala Ala  Cys Thr Gly Thr Cys  Gly Cys Ala 
    1310                 1315                 1320             


Cys Ala  Gly Thr Ala Cys Ala  Ala Thr Gly Ala Cys  Ala Thr Cys 
    1325                 1330                 1335             


Thr Ala  Thr Ala Cys Cys Ala  Ala Cys Thr Thr Ala  Cys Thr Ala 
    1340                 1345                 1350             


Ala Ala  Thr Gly Ala Thr Thr  Ala Thr Ala Gly Ala  Ala Ala Ala 
    1355                 1360                 1365             


Ala Thr  Cys Gly Cys Thr Thr  Cys Thr Ala Ala Gly  Thr Thr Ala 
    1370                 1375                 1380             


Thr Cys  Cys Ala Ala Gly Gly  Thr Thr Cys Ala Ala  Gly Thr Cys 
    1385                 1390                 1395             


Thr Cys  Ala Ala Ala Cys Cys  Cys Thr Cys Ala Ala  Cys Thr Gly 
    1400                 1405                 1410             


Ala Ala  Thr Cys Cys Gly Thr  Ala Thr Ala Ala Gly  Gly Ala Cys 
    1415                 1420                 1425             


Ala Thr  Ala Thr Thr Cys Cys  Ala Ala Gly Ala Ala  Ala Ala Ala 
    1430                 1435                 1440             


Thr Ala  Thr Gly Gly Ala Thr  Thr Ala Gly Ala Cys  Ala Ala Ala 
    1445                 1450                 1455             


Gly Ala  Cys Gly Cys Gly Thr  Cys Ala Gly Gly Ala  Ala Thr Cys 
    1460                 1465                 1470             


Thr Ala  Thr Thr Cys Gly Gly  Thr Ala Ala Ala Cys  Ala Thr Thr 
    1475                 1480                 1485             


Ala Ala  Cys Ala Ala Ala Thr  Thr Cys Gly Ala Cys  Gly Ala Thr 
    1490                 1495                 1500             


Ala Thr  Thr Thr Thr Gly Ala  Ala Gly Ala Ala Ala  Cys Thr Thr 
    1505                 1510                 1515             


Thr Ala  Cys Ala Gly Cys Thr  Thr Cys Ala Cys Gly  Gly Ala Gly 
    1520                 1525                 1530             


Thr Thr  Cys Gly Ala Cys Thr  Thr Gly Gly Cys Cys  Ala Cys Cys 
    1535                 1540                 1545             


Ala Ala  Ala Thr Thr Cys Cys  Ala Gly Gly Thr Cys  Ala Ala Ala 
    1550                 1555                 1560             


Thr Gly  Cys Cys Gly Ala Gly  Ala Gly Ala Cys Ala  Thr Ala Cys 
    1565                 1570                 1575             


Ala Thr  Cys Gly Gly Ala Cys  Gly Gly Cys Cys Thr  Ala Ala Gly 
    1580                 1585                 1590             


Thr Thr  Thr Thr Thr Thr Ala  Ala Gly Cys Thr Gly  Thr Cys Gly 
    1595                 1600                 1605             


Ala Ala  Thr Cys Thr Cys Cys  Thr Gly Ala Ala Thr  Gly Ala Thr 
    1610                 1615                 1620             


Thr Cys  Cys Ala Thr Ala Thr  Ala Cys Ala Ala Cys  Ala Thr Thr 
    1625                 1630                 1635             


Ala Gly  Thr Gly Ala Gly Gly  Gly Thr Thr Ala Cys  Ala Ala Thr 
    1640                 1645                 1650             


Ala Thr  Ala Ala Ala Thr Ala  Ala Cys Cys Thr Ala  Ala Ala Gly 
    1655                 1660                 1665             


Gly Thr  Gly Ala Ala Thr Thr  Thr Cys Cys Gly Ala  Gly Gly Cys 
    1670                 1675                 1680             


Cys Ala  Ala Ala Ala Cys Gly  Cys Cys Ala Ala Cys  Cys Thr Ala 
    1685                 1690                 1695             


Ala Ala  Thr Cys Cys Gly Cys  Gly Thr Ala Thr Cys  Ala Thr Thr 
    1700                 1705                 1710             


Ala Ala  Ala Cys Cys Cys Ala  Thr Cys Ala Cys Ala  Gly Gly Ala 
    1715                 1720                 1725             


Cys Gly  Gly Gly Gly Gly Thr  Thr Ala Gly Thr Gly  Ala Ala Gly 
    1730                 1735                 1740             


Ala Ala  Ala Ala Thr Ala Ala  Thr Cys Cys Gly Gly  Thr Thr Thr 
    1745                 1750                 1755             


<210>  11
<211>  1758
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Ala Thr Gly Gly Ala Cys Thr Cys Gly Gly Gly Cys Cys Gly Gly Gly 
1               5                   10                  15      


Ala Cys Thr Thr Cys Cys Thr Gly Ala Cys Cys Cys Thr Gly Cys Ala 
            20                  25                  30          


Cys Gly Gly Cys Cys Thr Ala Cys Ala Gly Gly Ala Thr Gly Ala Thr 
        35                  40                  45              


Gly Ala Gly Gly Ala Thr Cys Thr Ala Cys Ala Gly Gly Cys Gly Cys 
    50                  55                  60                  


Thr Gly Cys Thr Gly Ala Ala Gly Gly Gly Cys Ala Gly Cys Cys Ala 
65                  70                  75                  80  


Gly Cys Thr Cys Cys Thr Gly Ala Ala Gly Gly Thr Gly Ala Ala Gly 
                85                  90                  95      


Thr Cys Cys Ala Gly Cys Thr Cys Ala Thr Gly Gly Ala Gly Gly Ala 
            100                 105                 110         


Gly Ala Gly Ala Gly Cys Gly Cys Thr Thr Cys Thr Ala Cys Ala Ala 
        115                 120                 125             


Gly Thr Thr Gly Cys Ala Gly Gly Ala Gly Gly Ala Cys Thr Gly Cys 
    130                 135                 140                 


Ala Ala Gly Ala Cys Cys Ala Thr Cys Thr Gly Gly Cys Ala Gly Gly 
145                 150                 155                 160 


Ala Gly Thr Cys Cys Cys Gly Cys Ala Ala Gly Gly Thr Cys Ala Thr 
                165                 170                 175     


Gly Cys Gly Gly Ala Cys Cys Cys Cys Gly Gly Ala Gly Thr Cys Cys 
            180                 185                 190         


Cys Ala Gly Cys Thr Gly Thr Thr Cys Thr Cys Cys Ala Thr Cys Gly 
        195                 200                 205             


Ala Gly Gly Ala Cys Ala Thr Thr Cys Ala Gly Gly Ala Gly Gly Thr 
    210                 215                 220                 


Gly Cys Gly Ala Ala Thr Gly Gly Gly Gly Cys Ala Cys Cys Gly Cys 
225                 230                 235                 240 


Ala Cys Gly Gly Ala Gly Gly Gly Thr Cys Thr Gly Gly Ala Gly Ala 
                245                 250                 255     


Ala Gly Thr Thr Cys Gly Cys Cys Cys Gly Thr Gly Ala Thr Gly Thr 
            260                 265                 270         


Gly Cys Cys Cys Gly Ala Gly Gly Ala Cys Cys Gly Cys Thr Gly Cys 
        275                 280                 285             


Thr Thr Cys Thr Cys Cys Ala Thr Thr Gly Thr Cys Thr Thr Cys Ala 
    290                 295                 300                 


Ala Gly Gly Ala Cys Cys Ala Gly Cys Gly Cys Ala Ala Thr Ala Cys 
305                 310                 315                 320 


Ala Cys Thr Ala Gly Ala Cys Cys Thr Cys Ala Thr Cys Gly Cys Cys 
                325                 330                 335     


Cys Cys Ala Thr Cys Gly Cys Cys Ala Gly Cys Thr Gly Ala Thr Gly 
            340                 345                 350         


Cys Cys Cys Ala Gly Cys Ala Cys Thr Gly Gly Gly Thr Gly Cys Thr 
        355                 360                 365             


Gly Gly Gly Gly Cys Thr Gly Cys Ala Cys Ala Ala Gly Ala Thr Cys 
    370                 375                 380                 


Ala Thr Cys Cys Ala Cys Cys Ala Cys Thr Cys Ala Gly Gly Cys Thr 
385                 390                 395                 400 


Cys Cys Ala Thr Gly Gly Ala Cys Cys Ala Gly Cys Gly Thr Cys Ala 
                405                 410                 415     


Gly Ala Ala Gly Cys Thr Ala Cys Ala Gly Cys Ala Cys Thr Gly Gly 
            420                 425                 430         


Ala Thr Thr Cys Ala Cys Thr Cys Cys Thr Gly Cys Thr Thr Gly Cys 
        435                 440                 445             


Gly Ala Ala Ala Ala Gly Cys Thr Gly Ala Cys Ala Ala Ala Ala Ala 
    450                 455                 460                 


Cys Ala Ala Gly Gly Ala Cys Ala Ala Cys Ala Ala Gly Ala Thr Gly 
465                 470                 475                 480 


Ala Gly Cys Thr Thr Cys Ala Ala Gly Gly Ala Gly Cys Thr Gly Cys 
                485                 490                 495     


Ala Gly Ala Ala Cys Thr Thr Cys Cys Thr Gly Ala Ala Gly Gly Gly 
            500                 505                 510         


Thr Gly Gly Thr Gly Gly Thr Gly Gly Thr Ala Gly Cys Ala Thr Gly 
        515                 520                 525             


Cys Cys Ala Ala Ala Ala Ala Thr Cys Ala Ala Cys Ala Gly Cys Thr 
    530                 535                 540                 


Thr Thr Ala Ala Thr Thr Ala Cys Ala Ala Thr Gly Ala Cys Cys Cys 
545                 550                 555                 560 


Thr Gly Thr Ala Ala Ala Cys Gly Ala Thr Cys Gly Thr Ala Cys Cys 
                565                 570                 575     


Ala Thr Cys Cys Thr Ala Thr Ala Cys Ala Thr Ala Ala Ala Gly Cys 
            580                 585                 590         


Cys Gly Gly Gly Thr Gly Gly Gly Thr Ala Thr Cys Ala Cys Gly Ala 
        595                 600                 605             


Gly Thr Thr Cys Thr Ala Cys Ala Ala Ala Thr Cys Thr Thr Thr Cys 
    610                 615                 620                 


Ala Ala Thr Ala Thr Thr Ala Thr Gly Ala Ala Gly Ala Ala Thr Ala 
625                 630                 635                 640 


Thr Ala Thr Gly Gly Ala Thr Thr Ala Thr Ala Cys Cys Thr Gly Ala 
                645                 650                 655     


Gly Cys Gly Thr Ala Ala Cys Gly Thr Thr Ala Thr Thr Gly Gly Thr 
            660                 665                 670         


Ala Cys Gly Ala Cys Ala Cys Cys Gly Cys Ala Ala Gly Ala Thr Thr 
        675                 680                 685             


Thr Thr Cys Ala Thr Cys Cys Ala Cys Cys Thr Ala Cys Thr Thr Cys 
    690                 695                 700                 


Gly Thr Thr Gly Ala Ala Gly Ala Ala Cys Gly Gly Thr Gly Ala Cys 
705                 710                 715                 720 


Thr Cys Thr Thr Cys Cys Thr Ala Thr Thr Ala Cys Gly Ala Cys Cys 
                725                 730                 735     


Cys Cys Ala Ala Thr Thr Ala Thr Cys Thr Cys Cys Ala Gly Thr Cys 
            740                 745                 750         


Gly Gly Ala Thr Gly Ala Ala Gly Ala Gly Ala Ala Gly Gly Ala Cys 
        755                 760                 765             


Ala Gly Ala Thr Thr Cys Cys Thr Thr Ala Ala Ala Ala Thr Ala Gly 
    770                 775                 780                 


Thr Ala Ala Cys Cys Ala Ala Ala Ala Thr Cys Thr Thr Thr Ala Ala 
785                 790                 795                 800 


Cys Ala Gly Gly Ala Thr Thr Ala Ala Thr Ala Ala Cys Ala Ala Thr 
                805                 810                 815     


Cys Thr Ala Gly Cys Cys Gly Gly Ala Ala Gly Thr Ala Thr Thr Thr 
            820                 825                 830         


Thr Gly Cys Thr Thr Gly Ala Ala Gly Ala Gly Cys Thr Thr Ala Gly 
        835                 840                 845             


Thr Ala Ala Ala Gly Cys Thr Ala Ala Thr Cys Cys Thr Thr Ala Cys 
    850                 855                 860                 


Cys Thr Ala Gly Gly Thr Ala Ala Cys Gly Ala Thr Gly Ala Thr Ala 
865                 870                 875                 880 


Cys Ala Cys Cys Ala Gly Ala Cys Ala Ala Cys Cys Ala Gly Thr Thr 
                885                 890                 895     


Thr Cys Ala Thr Ala Thr Ala Gly Gly Cys Gly Ala Thr Gly Cys Ala 
            900                 905                 910         


Thr Cys Cys Gly Cys Cys Gly Thr Gly Gly Ala Ala Ala Thr Cys Ala 
        915                 920                 925             


Ala Ala Thr Thr Thr Ala Gly Cys Ala Ala Thr Gly Gly Ala Thr Cys 
    930                 935                 940                 


Ala Cys Ala Gly Cys Ala Thr Ala Thr Thr Cys Thr Cys Thr Thr Gly 
945                 950                 955                 960 


Cys Cys Cys Ala Ala Cys Gly Thr Thr Ala Thr Thr Ala Thr Ala Ala 
                965                 970                 975     


Thr Gly Gly Gly Gly Gly Cys Gly Gly Ala Ala Cys Cys Ala Ala Ala 
            980                 985                 990         


Thr Thr Thr Ala Thr Thr Thr Thr  Thr Gly Ala Cys Ala  Thr Ala Thr 
        995                 1000                 1005             


Cys Ala  Gly Ala Gly Ala Ala  Ala Thr Ala Thr Thr  Ala Gly Cys 
    1010                 1015                 1020             


Gly Cys  Cys Ala Gly Ala Ala  Ala Thr Ala Ala Cys  Thr Ala Thr 
    1025                 1030                 1035             


Ala Ala  Gly Cys Cys Gly Thr  Cys Ala Ala Ala Cys  Cys Ala Thr 
    1040                 1045                 1050             


Gly Gly  Gly Thr Thr Cys Gly  Gly Thr Ala Gly Cys  Ala Thr Ala 
    1055                 1060                 1065             


Gly Cys  Ala Ala Thr Cys Gly  Thr Thr Ala Cys Thr  Thr Thr Thr 
    1070                 1075                 1080             


Thr Cys  Thr Cys Cys Cys Gly  Ala Ala Thr Ala Cys  Ala Gly Thr 
    1085                 1090                 1095             


Thr Thr  Thr Cys Gly Cys Thr  Thr Cys Ala Ala Thr  Gly Ala Thr 
    1100                 1105                 1110             


Ala Ala  Thr Ala Gly Thr Ala  Thr Ala Ala Ala Thr  Gly Ala Gly 
    1115                 1120                 1125             


Thr Thr  Thr Ala Thr Cys Cys  Ala Ala Gly Ala Cys  Cys Cys Cys 
    1130                 1135                 1140             


Gly Cys  Ala Cys Thr Cys Ala  Cys Gly Cys Thr Thr  Ala Thr Gly 
    1145                 1150                 1155             


Cys Ala  Cys Gly Ala Ala Cys  Thr Cys Ala Thr Ala  Cys Ala Cys 
    1160                 1165                 1170             


Thr Cys  Thr Thr Thr Ala Cys  Ala Cys Gly Gly Cys  Cys Thr Gly 
    1175                 1180                 1185             


Thr Ala  Thr Gly Gly Cys Gly  Cys Thr Ala Ala Gly  Gly Gly Gly 
    1190                 1195                 1200             


Ala Thr  Ala Ala Cys Cys Ala  Cys Thr Ala Cys Gly  Thr Gly Thr 
    1205                 1210                 1215             


Ala Cys  Cys Ala Thr Thr Ala  Cys Thr Cys Ala Gly  Cys Ala Ala 
    1220                 1225                 1230             


Cys Ala  Gly Ala Ala Cys Cys  Cys Ala Thr Thr Gly  Ala Thr Ala 
    1235                 1240                 1245             


Ala Cys  Gly Ala Ala Cys Ala  Gly Gly Ala Ala Gly  Gly Gly Cys 
    1250                 1255                 1260             


Ala Thr  Thr Ala Ala Ala Ala  Thr Cys Gly Ala Gly  Gly Ala Ala 
    1265                 1270                 1275             


Thr Thr  Thr Cys Thr Thr Ala  Cys Ala Thr Thr Thr  Gly Gly Ala 
    1280                 1285                 1290             


Gly Gly  Cys Ala Ala Cys Gly  Ala Thr Cys Thr Gly  Ala Ala Cys 
    1295                 1300                 1305             


Ala Thr  Thr Ala Thr Ala Ala  Cys Thr Gly Thr Cys  Gly Cys Ala 
    1310                 1315                 1320             


Cys Ala  Gly Thr Ala Cys Ala  Ala Thr Gly Ala Cys  Ala Thr Cys 
    1325                 1330                 1335             


Thr Ala  Thr Ala Cys Cys Ala  Ala Cys Thr Thr Ala  Cys Thr Ala 
    1340                 1345                 1350             


Ala Ala  Thr Gly Ala Thr Thr  Ala Thr Ala Gly Ala  Ala Ala Ala 
    1355                 1360                 1365             


Ala Thr  Cys Gly Cys Thr Thr  Cys Thr Ala Ala Gly  Thr Thr Ala 
    1370                 1375                 1380             


Thr Cys  Cys Ala Ala Gly Gly  Thr Thr Cys Ala Ala  Gly Thr Cys 
    1385                 1390                 1395             


Thr Cys  Ala Ala Ala Cys Cys  Cys Thr Cys Ala Ala  Cys Thr Gly 
    1400                 1405                 1410             


Ala Ala  Thr Cys Cys Gly Thr  Ala Thr Ala Ala Gly  Gly Ala Cys 
    1415                 1420                 1425             


Ala Thr  Ala Thr Thr Cys Cys  Ala Ala Gly Ala Ala  Ala Ala Ala 
    1430                 1435                 1440             


Thr Ala  Thr Gly Gly Ala Thr  Thr Ala Gly Ala Cys  Ala Ala Ala 
    1445                 1450                 1455             


Gly Ala  Cys Gly Cys Gly Thr  Cys Ala Gly Gly Ala  Ala Thr Cys 
    1460                 1465                 1470             


Thr Ala  Thr Thr Cys Gly Gly  Thr Ala Ala Ala Cys  Ala Thr Thr 
    1475                 1480                 1485             


Ala Ala  Cys Ala Ala Ala Thr  Thr Cys Gly Ala Cys  Gly Ala Thr 
    1490                 1495                 1500             


Ala Thr  Thr Thr Thr Gly Ala  Ala Gly Ala Ala Ala  Cys Thr Thr 
    1505                 1510                 1515             


Thr Ala  Cys Ala Gly Cys Thr  Thr Cys Ala Cys Gly  Gly Ala Gly 
    1520                 1525                 1530             


Thr Thr  Cys Gly Ala Cys Thr  Thr Gly Gly Cys Cys  Ala Cys Cys 
    1535                 1540                 1545             


Ala Ala  Ala Thr Thr Cys Cys  Ala Gly Gly Thr Cys  Ala Ala Ala 
    1550                 1555                 1560             


Thr Gly  Cys Cys Gly Ala Gly  Ala Gly Ala Cys Ala  Thr Ala Cys 
    1565                 1570                 1575             


Ala Thr  Cys Gly Gly Ala Cys  Gly Gly Cys Cys Thr  Ala Ala Gly 
    1580                 1585                 1590             


Thr Thr  Thr Thr Thr Thr Ala  Ala Gly Cys Thr Gly  Thr Cys Gly 
    1595                 1600                 1605             


Ala Ala  Thr Cys Thr Cys Cys  Thr Gly Ala Ala Thr  Gly Ala Thr 
    1610                 1615                 1620             


Thr Cys  Cys Ala Thr Ala Thr  Ala Cys Ala Ala Cys  Ala Thr Thr 
    1625                 1630                 1635             


Ala Gly  Thr Gly Ala Gly Gly  Gly Thr Thr Ala Cys  Ala Ala Thr 
    1640                 1645                 1650             


Ala Thr  Ala Ala Ala Thr Ala  Ala Cys Cys Thr Ala  Ala Ala Gly 
    1655                 1660                 1665             


Gly Thr  Gly Ala Ala Thr Thr  Thr Cys Cys Gly Ala  Gly Gly Cys 
    1670                 1675                 1680             


Cys Ala  Ala Ala Ala Cys Gly  Cys Cys Ala Ala Cys  Cys Thr Ala 
    1685                 1690                 1695             


Ala Ala  Thr Cys Cys Gly Cys  Gly Thr Ala Thr Cys  Ala Thr Thr 
    1700                 1705                 1710             


Ala Ala  Ala Cys Cys Cys Ala  Thr Cys Ala Cys Ala  Gly Gly Ala 
    1715                 1720                 1725             


Cys Gly  Gly Gly Gly Gly Thr  Thr Ala Gly Thr Gly  Ala Ala Gly 
    1730                 1735                 1740             


Ala Ala  Ala Ala Thr Ala Ala  Thr Cys Cys Gly Gly  Thr Thr Thr 
    1745                 1750                 1755             


<210>  12
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Thr Ala Ile Ile Lys Glu Ile Val Ser Arg Asn Lys Arg Arg Tyr 
1               5                   10                  15      


Gln Glu Asp Gly Phe Asp Leu Asp Leu Thr Tyr Ile Tyr Pro Asn Ile 
            20                  25                  30          


Ile Ala Met Gly Phe Pro Ala Glu Arg Leu Glu Gly Val Tyr Arg Asn 
        35                  40                  45              


Asn Ile Asp Asp Val Val Arg Phe Leu Asp Ser Lys His Lys Asn His 
    50                  55                  60                  


Tyr Lys Ile Tyr Asn Leu Cys Ala Glu Arg His Tyr Asp Thr Ala Lys 
65                  70                  75                  80  


Phe Asn Cys Arg Val Ala Gln Tyr Pro Phe Glu Asp His Asn Pro Pro 
                85                  90                  95      


Gln Leu Glu Leu Ile Lys Pro Phe Cys Glu Asp Leu Asp Gln Trp Leu 
            100                 105                 110         


Ser Glu Asp Asp Asn His Val Ala Ala Ile His Cys Lys Ala Gly Lys 
        115                 120                 125             


Gly Arg Thr Gly Val Met Ile Cys Ala Tyr Leu Leu His Arg Gly Lys 
    130                 135                 140                 


Phe Leu Lys Ala Gln Glu Ala Leu Asp Phe Tyr Gly Glu Val Arg Thr 
145                 150                 155                 160 


Arg Asp Lys Lys Gly Val Thr Ile Pro Ser Gln Arg Arg Tyr Val Tyr 
                165                 170                 175     


Tyr Tyr Ser Tyr Leu Leu Lys Asn His Leu Asp Tyr Arg Pro Val Ala 
            180                 185                 190         


Leu Leu Phe His Lys Met Met Phe Glu Thr Ile Pro Met Phe Ser Gly 
        195                 200                 205             


Gly Thr Cys Asn Pro Gln Phe Val Val Cys Gln Leu Lys Val Lys Ile 
    210                 215                 220                 


Tyr Ser Ser Asn Ser Gly Pro Thr Arg Arg Glu Asp Lys Phe Met Tyr 
225                 230                 235                 240 


Phe Glu Phe Pro Gln Pro Leu Pro Val Cys Gly Asp Ile Lys Val Glu 
                245                 250                 255     


Phe Phe His Lys Gln Asn Lys Met Leu Lys Lys Asp Lys Met Phe His 
            260                 265                 270         


Phe Trp Val Asn Thr Phe Phe Ile Pro Gly Pro Glu Glu Thr Ser Glu 
        275                 280                 285             


Lys Val Glu Asn Gly Ser Leu Cys Asp Gln Glu Ile Asp Ser Ile Cys 
    290                 295                 300                 


Ser Ile Glu Arg Ala Asp Asn Asp Lys Glu Tyr Leu Val Leu Thr Leu 
305                 310                 315                 320 


Thr Lys Asn Asp Leu Asp Lys Ala Asn Lys Asp Lys Ala Asn Arg Tyr 
                325                 330                 335     


Phe Ser Pro Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu 
            340                 345                 350         


Glu Pro Ser Asn Pro Glu Ala Ser Ser Ser Thr Ser Val Thr Pro Asp 
        355                 360                 365             


Val Ser Asp Asn Glu Pro Asp His Tyr Arg Tyr Ser Asp Thr Thr Asp 
    370                 375                 380                 


Ser Asp Pro Glu Asn Glu Pro Phe Asp Glu Asp Gln His Thr Gln Ile 
385                 390                 395                 400 


Thr Lys Val 
            


<210>  13
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Asn Gly Ser Leu Cys Asp Gln Glu Ile Asp Ser Ile Cys Ser Ile Met 
1               5                   10                  15      


Glu Lys Ala Asp 
            20  


<210>  14
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Cys Lys Asn Ile Val Ser Val Lys Gly Ile Arg Lys Ser Ile Cys Ile 
1               5                   10                  15      


Glu Ile Asn Asn Gly Glu Leu Phe Phe Val Ala Ser Glu Asn Ser Tyr 
            20                  25                  30          


Asn Asp Asp Asn Ile Asn Thr Pro Lys Glu Ile Asp Asp Thr Val Thr 
        35                  40                  45              


Ser Asn Asn Asn Tyr Glu Asn Asp Leu Asp Gln Val Ile Leu Asn Phe 
    50                  55                  60                  


Asn Ser Glu Ser Ala Pro Gly Leu Ser Asp Glu Lys Leu Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Asn Asp Ala Tyr Ile Pro Lys Tyr Asp Ser Asn Gly Thr Ser 
                85                  90                  95      


Asp Ile Glu Gln His Asp Val Asn Glu Leu Asn Val Phe Phe Tyr Leu 
            100                 105                 110         


Asp Ala Gln Lys Val Pro Glu Gly Glu Asn Asn Val Asn Leu Thr Ser 
        115                 120                 125             


Ser Ile Asp Thr Ala Leu Leu Glu Gln Pro Lys Ile Tyr Thr Phe Phe 
    130                 135                 140                 


Ser Ser Glu Phe Ile Asn Asn Val Asn Lys Pro Val Gln Ala Ala Leu 
145                 150                 155                 160 


Phe Val Ser Trp Ile Gln Gln Val Leu Val Asp Phe Thr Thr Glu Ala 
                165                 170                 175     


Asn Gln Lys Ser Thr Val Asp Lys Ile Ala Asp Ile Ser Ile Val Val 
            180                 185                 190         


Pro Tyr Ile Gly Leu Ala Leu Asn Ile Gly Asn Glu Ala Gln Lys Gly 
        195                 200                 205             


Asn Phe Lys Asp Ala Leu Glu Leu Leu Gly Ala Gly Ile Leu Leu Glu 
    210                 215                 220                 


Phe Glu Pro Glu Leu Leu Ile Pro Thr Ile Leu Val Phe Thr Ile Lys 
225                 230                 235                 240 


Ser Phe Leu Gly Ser Ser Asp Asn Lys Asn Lys Val Ile Lys Ala Ile 
                245                 250                 255     


Asn Asn Ala Leu Lys Glu Arg Asp Glu Lys Trp Lys Glu Val Tyr Ser 
            260                 265                 270         


Phe Ile Val Ser Asn Trp Met Thr Lys Ile Asn Thr Gln Phe Asn Lys 
        275                 280                 285             


Arg Lys Glu Gln Met Tyr Gln Ala Leu Gln Asn Gln Val Asn Ala Ile 
    290                 295                 300                 


Lys Thr Ile Ile Glu Ser Lys Tyr Asn Ser Tyr Thr Leu Glu Glu Lys 
305                 310                 315                 320 


Asn Glu Leu Thr Asn Lys Tyr Asp Ile Lys Gln Ile Glu Asn Glu Leu 
                325                 330                 335     


Asn Gln Lys Val Ser Ile Ala Met Asn Asn Ile Asp Arg Phe Leu Thr 
            340                 345                 350         


Glu Ser Ser Ile Ser Tyr Leu Met Lys Leu Ile Asn Glu Val Lys Ile 
        355                 360                 365             


Asn Lys Leu Arg Glu Tyr Asp Glu Asn Val Lys Thr Tyr Leu Leu Asn 
    370                 375                 380                 


Tyr Ile Ile Gln His Gly Ser Ile Leu Gly Glu Ser Gln Gln Glu Leu 
385                 390                 395                 400 


Asn Ser Met Val Thr Asp Thr Leu Asn Asn Ser Ile Pro Phe Lys Leu 
                405                 410                 415     


Ser Ser Tyr Thr Asp Asp Lys Ile Leu Ile Ser Tyr Phe Asn Lys Phe 
            420                 425                 430         


Phe Lys Arg Ile Lys Ser 
        435             


<210>  15
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Ser Ser Val Leu Asn Met Arg Tyr Lys Asn Asp Lys Tyr Val Asp Thr 
1               5                   10                  15      


Ser Gly Tyr Asp Ser Asn Ile Asn Ile Asn Gly Asp Val Tyr Lys Tyr 
            20                  25                  30          


Pro Thr Asn Lys Asn Gln Phe Glu Ile Tyr Asn Asp Lys Leu Ser Glu 
        35                  40                  45              


Val Asn Ile Ser Gln Asn Asp Tyr Ile Ile Tyr Asp Asn Lys Tyr Lys 
    50                  55                  60                  


Asn Phe Ser Ile Ser Phe Trp Val Arg Ile Pro Asn Tyr Asp Asn Lys 
65                  70                  75                  80  


Ile Val Asn Val Asn Asn Glu Tyr Thr Ile Ile Asn Cys Met Arg Asp 
                85                  90                  95      


Asn Asn Ser Gly Trp Lys Val Ser Leu Asn His Asn Glu Ile Ile Trp 
            100                 105                 110         


Thr Leu Gln Asp Asn Ala Gly Ile Asn Gln Lys Leu Ala Phe Asn Tyr 
        115                 120                 125             


Gly Asn Ala Asn Gly Ile Ser Asp Tyr Ile Asn Lys Trp Ile Phe Val 
    130                 135                 140                 


Thr Ile Thr Asn Asp Arg Leu Gly Asp Ser Lys Leu Tyr Ile Asn Gly 
145                 150                 155                 160 


Asn Leu Ile Asp Gln Lys Ser Ile Leu Asn Leu Gly Asn Ile His Val 
                165                 170                 175     


Ser Asp Asn Ile Leu Phe Lys Ile Val Asn Cys Ser Tyr Thr Arg Tyr 
            180                 185                 190         


Ile Gly Ile Arg Tyr Phe Asn Ile Phe Asp Lys Glu Leu Asp Glu Thr 
        195                 200                 205             


Glu Ile Gln Thr Leu Tyr Ser Asn Glu Pro Asn Thr Asn Ile Leu Lys 
    210                 215                 220                 


Asp Phe Trp Gly Asn Tyr Leu Leu Tyr Asp Lys Glu Tyr Tyr Leu Leu 
225                 230                 235                 240 


Asn Val Leu Lys Pro Asn Asn Phe Ile Asp Arg Arg Lys Asp Ser Thr 
                245                 250                 255     


Leu Ser Ile Asn Asn Ile Arg Ser Thr Ile Leu Leu Ala Asn Arg Leu 
            260                 265                 270         


Tyr Ser Gly Ile Lys Val Lys Ile Gln Arg Val Asn Asn Ser Ser Thr 
        275                 280                 285             


Asn Asp Asn Leu Val Arg Lys Asn Asp Gln Val Tyr Ile Asn Phe Val 
    290                 295                 300                 


Ala Ser Lys Thr His Leu Phe Pro Leu Tyr Ala Asp Thr Ala Thr Thr 
305                 310                 315                 320 


Asn Lys Glu Lys Thr Ile Lys Ile Ser Ser Ser Gly Asn Arg Phe Asn 
                325                 330                 335     


Gln Val Val Val Met Asn Ser Val Gly Asn Asn Cys Thr Met Asn Phe 
            340                 345                 350         


Lys Asn Asn Asn Gly Asn Asn Ile Gly Leu Leu Gly Phe Lys Ala Asp 
        355                 360                 365             


Thr Val Val Ala Ser Thr Trp Tyr Tyr Thr His Met Arg Asp His Thr 
    370                 375                 380                 


Asn Ser Asn Gly Cys Phe Trp Asn Phe Ile Ser Glu Glu His Gly Trp 
385                 390                 395                 400 


Gln Glu Lys 
            


<210>  16
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Met Ala Glu Asp Ala Asp Met Arg Asn Glu Leu Glu Glu Met Gln Arg 
1               5                   10                  15      


Arg Ala Asp Gln Leu Ala Asp Glu Ser Leu Glu Ser Thr Arg Arg Met 
            20                  25                  30          


Leu Gln Leu Val Glu Glu Ser Lys Asp Ala Gly Ile Arg Thr Leu Val 
        35                  40                  45              


Met Leu Asp Glu Gln Gly Glu Gln Leu Glu Arg Ile Glu Glu Gly Met 
    50                  55                  60                  


Asp Gln Ile Asn Lys Asp Met Lys Glu Ala Glu Lys Asn Leu Thr Asp 
65                  70                  75                  80  


Leu Gly Lys Phe Cys Gly Leu Cys Val Cys Pro Cys Asn Lys Leu Lys 
                85                  90                  95      


Ser Ser Asp Ala Tyr Lys Lys Ala Trp Gly Asn Asn Gln Asp Gly Val 
            100                 105                 110         


Val Ala Ser Gln Pro Ala Arg Val Val Asp Glu Arg Glu Gln Met Ala 
        115                 120                 125             


Ile Ser Gly Gly Phe Ile Arg Arg Val Thr Asn Asp Ala Arg Glu Asn 
    130                 135                 140                 


Glu Met Asp Glu Asn Leu Glu Gln Val Ser Gly Ile Ile Gly Asn Leu 
145                 150                 155                 160 


Arg His Met Ala Leu Asp Met Gly Asn Glu Ile Asp Thr Gln Asn Arg 
                165                 170                 175     


Gln Ile Asp Arg Ile Met Glu Lys Ala Asp Ser Asn Lys Thr Arg Ile 
            180                 185                 190         


Asp Glu Ala Asn Gln Arg Ala Thr Lys Met Leu Gly Ser Gly 
        195                 200                 205     


<210>  17
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Arg Gln Ile Asp Arg Ile Met Glu Lys Ala 
1               5                   10  


<210>  18
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  18

Asn Pro Asp Arg Glu Gly Trp Leu Leu Lys Leu Gly Gly Gly Arg Val 
1               5                   10                  15      


Lys Thr Trp Lys Arg Arg Trp Phe Ile Leu Thr Asp Asn Cys Leu Tyr 
            20                  25                  30          


Tyr Phe Glu Tyr Thr Thr Asp Lys Glu Pro Arg Gly Ile Ile Pro Leu 
        35                  40                  45              


Glu Asn Leu Ser Ile Arg Glu Val Glu Asp Ser Lys Lys Pro Asn Cys 
    50                  55                  60                  


Phe Glu Leu Tyr Ile Pro Asp Asn Lys Asp Gln Val Ile Lys Ala Cys 
65                  70                  75                  80  


Lys Thr Glu Ala Asp Gly Arg Val Val Glu Gly Asn His Thr Val Tyr 
                85                  90                  95      


Arg Ile Ser Ala Pro Thr Pro Glu Glu Lys Glu Glu Trp Ile Lys Cys 
            100                 105                 110         


Ile Lys Ala Ala Ile Ser 
        115             


<210>  19
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  19

Asn Pro Asp Arg Glu Gly Trp Leu Leu Lys Leu Gly Gly Gly Arg Val 
1               5                   10                  15      


Lys Thr Trp Lys Arg Arg Trp Phe Ile Leu Thr Asp Asn Cys Leu Tyr 
            20                  25                  30          


Tyr Phe Glu Tyr Thr Thr Asp Lys Glu Pro Arg Gly Ile Ile Pro Leu 
        35                  40                  45              


Glu Asn Leu Ser Ile Arg Glu Val Asp Asp Pro Arg Lys Pro Asn Cys 
    50                  55                  60                  


Phe Glu Leu Tyr Ile Pro Asn Asn Lys Gly Gln Leu Ile Lys Ala Cys 
65                  70                  75                  80  


Lys Thr Glu Ala Asp Gly Arg Val Val Glu Gly Asn His Met Val Tyr 
                85                  90                  95      


Arg Ile Ser Ala Pro Thr Gln Glu Glu Lys Asp Glu Trp Ile Lys Ser 
            100                 105                 110         


Ile Gln Ala Ala Val Ser 
        115             


<210>  20
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  20

Asn Pro Asp Arg Glu Gly Trp Leu Leu Lys Leu Gly Gly Gly Arg Val 
1               5                   10                  15      


Lys Thr Trp Lys Arg Arg Trp Phe Ile Leu Thr Asp Asn Cys Leu Tyr 
            20                  25                  30          


Tyr Phe Glu Tyr Thr Thr Asp Lys Glu Pro Arg Gly Ile Ile Pro Leu 
        35                  40                  45              


Glu Asn Leu Ser Ile Arg Glu Val Glu Asp Pro Arg Lys Pro Asn Cys 
    50                  55                  60                  


Phe Glu Leu Tyr Asn Pro Ser His Lys Gly Gln Val Ile Lys Ala Cys 
65                  70                  75                  80  


Lys Thr Glu Ala Asp Gly Arg Val Val Glu Gly Asn His Val Val Tyr 
                85                  90                  95      


Arg Ile Ser Ala Pro Ser Pro Glu Glu Lys Glu Glu Trp Met Lys Ser 
            100                 105                 110         


Ile Lys Ala Ser Ile Ser 
        115             


<210>  21
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  21

Ala Val Ile Leu Glu Ser Ile Phe Leu Lys Arg Ser Gln Gln Lys Lys 
1               5                   10                  15      


Lys Thr Ser Pro Leu Asn Phe Lys Lys Arg Leu Phe Leu Leu Thr Val 
            20                  25                  30          


His Lys Leu Ser Tyr Tyr Glu Tyr Asp Phe Glu Arg Gly Arg Arg Gly 
        35                  40                  45              


Ser Lys Lys Gly Ser Ile Asp Val Glu Lys Ile Thr Cys Val Glu Thr 
    50                  55                  60                  


Val Val Pro Glu Lys Asn Pro Pro Pro Glu Arg Gln Ile Pro Arg Arg 
65                  70                  75                  80  


Gly Glu Glu Ser Ser Glu Met Glu Gln Ile Ser Ile Ile Glu Arg Phe 
                85                  90                  95      


Pro Tyr Pro Phe Gln Val Val Tyr Asp Glu Gly Pro Leu Tyr Val Phe 
            100                 105                 110         


Ser Pro Thr Glu Glu Leu Arg Lys Arg Trp Ile His Gln Leu Lys Asn 
        115                 120                 125             


Val Ile Arg 
    130     


<210>  22
<211>  1209
<212>  DNA
<213>  Homo sapiens

<400>  22
atgacagcca tcatcaaaga gatcgttagc agaaacaaaa ggagatatca agaggatgga       60

ttcgacttag acttgaccta tatttatcca aacattattg ctatgggatt tcctgcagaa      120

agacttgaag gcgtatacag gaacaatatt gatgatgtag taaggttttt ggattcaaag      180

cataaaaacc attacaagat atacaatctt tgtgctgaaa gacattatga caccgccaaa      240

tttaattgca gagttgcaca atatcctttt gaagaccata acccaccaca gctagaactt      300

atcaaaccct tttgtgaaga tcttgaccaa tggctaagtg aagatgacaa tcatgttgca      360

gcaattcact gtaaagctgg aaagggacga actggtgtaa tgatatgtgc atatttatta      420

catcggggca aatttttaaa ggcacaagag gccctagatt tctatgggga agtaaggacc      480

agagacaaaa agggagtaac tattcccagt cagaggcgct atgtgtatta ttatagctac      540

ctgttaaaga atcatctgga ttatagacca gtggcactgt tgtttcacaa gatgatgttt      600

gaaactattc caatgttcag tggcggaact tgcaatcctc agtttgtggt ctgccagcta      660

aaggtgaaga tatattcctc caattcagga cccacacgac gggaagacaa gttcatgtac      720

tttgagttcc ctcagccgtt acctgtgtgt ggtgatatca aagtagagtt cttccacaaa      780

cagaacaaga tgctaaaaaa ggacaaaatg tttcactttt gggtaaatac attcttcata      840

ccaggaccag aggaaacctc agaaaaagta gaaaatggaa gtctatgtga tcaagaaatc      900

gatagcattt gcagtataga gcgtgcagat aatgacaagg aatatctagt acttacttta      960

acaaaaaatg atcttgacaa agcaaataaa gacaaagcca accgatactt ttctccaaat     1020

tttaaggtga agctgtactt cacaaaaaca gtagaggagc cgtcaaatcc agaggctagc     1080

agttcaactt ctgtaacacc agatgttagt gacaatgaac ctgatcatta tagatattct     1140

gacaccactg actctgatcc agagaatgaa ccttttgatg aagatcagca tacacaaatt     1200

acaaaagtc                                                             1209


<210>  23
<211>  354
<212>  DNA
<213>  Homo sapiens

<400>  23
aatccagacc gagaaggctg gctattgaaa ctcggaggtg gcagggtaaa gacttggaag       60

agacgctggt tcattctgac tgacaactgc ctttactact ttgagtatac cacggataag      120

gagccccgtg gaatcatccc tttagagaat ctgagtatcc gggaagtgga ggactccaaa      180

aaaccaaact gctttgagct ttatatcccc gacaataaag accaagttat caaggcctgc      240

aagaccgagg ctgacgggcg ggtggtggag gggaaccaca ctgtttaccg gatctcagct      300

ccgacgcccg aggagaagga ggagtggatt aagtgcatta aagcagccat cagc            354


<210>  24
<211>  354
<212>  DNA
<213>  Homo sapiens

<400>  24
aacccggacc gggagggctg gctcctgaag ctggggggcg ggcgggtgaa gacgtggaag       60

cggcgctggt ttatcctcac agacaactgc ctctactact ttgagtacac cacggacaag      120

gagccccgag gaatcatccc cctggagaat ctgagcatcc gagaggtgga cgacccccgg      180

aaaccgaact gctttgaact ttacatcccc aacaacaagg ggcagctcat caaagcctgc      240

aaaactgagg cggacggccg agtggtggag ggaaaccaca tggtgtaccg gatctcggcc      300

cccacgcagg aggagaagga cgagtggatc aagtccatcc aggcggctgt gagt            354


<210>  25
<211>  354
<212>  DNA
<213>  Homo sapiens

<400>  25
aaccccgacc gcgagggctg gctcctgaag ctgggagggg gccgtgtgaa gacctggaag       60

cgccggtggt tcatcctgac cgataactgc ctctattact ttgaatacac aacagataag      120

gagcccaggg gaatcatccc gttggaaaac ctcagcatca gggaggtgga ggacccccgg      180

aaacccaact gttttgagct ctacaatccc agccacaaag ggcaggtcat caaggcctgt      240

aagactgagg ccgacggccg cgtggtagag gggaaccatg tggtgtaccg gatctcagcc      300

ccgagcccgg aggagaagga ggagtggatg aaatccatca aagccagtat cagc            354


<210>  26
<211>  393
<212>  DNA
<213>  Homo sapiens

<400>  26
gcagtgattc tggagagcat ctttctgaag cgatcccaac agaaaaagaa aacatcacct       60

ctaaacttca agaagcgcct gtttctcttg accgtgcaca aactctccta ctatgagtat      120

gactttgaac gtgggagaag aggcagtaag aagggttcaa tagatgttga gaagatcact      180

tgtgttgaaa cagtggttcc tgaaaaaaat cctcctccag aaagacagat tccgagaaga      240

ggtgaagagt ccagtgaaat ggagcaaatt tcaatcattg aaaggttccc ttatcccttc      300

caggttgtat atgatgaagg gcctctctac gtcttctccc caactgaaga actaaggaag      360

cggtggattc accagctcaa aaacgtaatc cgg                                   393


<210>  27
<211>  389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27

Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      


Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          


Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              


Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  


His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  


Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      


Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         


Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             


Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 


Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 


Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     


Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         


Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             


Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 


Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 


Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     


Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         


Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             


Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 


Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 


Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     


Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         


Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Asn 
        355                 360                 365             


Ser Ser Ser Gly Gly Ser Gly Gly Ser Glu Asn Gly Ser Leu Cys Asp 
    370                 375                 380                 


Gln Glu Ile Asp Ser 
385                 


<210>  28
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28

Ile Cys Ser Ile Glu Arg Ala Asp Asn Gly Gly Ser Gly Gly Ser Pro 
1               5                   10                  15      


Pro Tyr Thr Ile Thr Tyr Phe Pro Val Arg Gly Arg Cys Glu Ala Met 
            20                  25                  30          


Arg Met Leu Leu Ala Asp Gln Asp Gln Ser Trp Lys Glu Glu Val Val 
        35                  40                  45              


Thr Met Glu Thr Trp Pro Pro Leu Lys Pro Ser Cys Leu Phe Arg Gln 
    50                  55                  60                  


Leu Pro Lys Phe Gln Asp Gly Asp Leu Thr Leu Tyr Gln Ser Asn Ala 
65                  70                  75                  80  


Ile Leu Arg His Leu Gly Arg Ser Phe Gly Leu Tyr Gly Lys Asp Gln 
                85                  90                  95      


Lys Glu Ala Ala Leu Val Asp Met Val Asn Asp Gly Val Glu Asp Leu 
            100                 105                 110         


Arg Cys Lys Tyr Ala Thr Leu Ile Tyr Thr Asn Tyr Glu Ala Gly Lys 
        115                 120                 125             


Glu Lys Tyr Val Lys Glu Leu Pro Glu His Leu Lys Pro Phe Glu Thr 
    130                 135                 140                 


Leu Leu Ser Gln Asn Gln Gly Gly Gln Ala Phe Val Val Gly Ser Gln 
145                 150                 155                 160 


Ile Ser Phe Ala Asp Tyr Asn Leu Leu Asp Leu Leu Arg Ile His Gln 
                165                 170                 175     


Val Leu Asn Pro Ser Cys Leu Asp Ala Phe Pro Leu Leu Ser Ala Tyr 
            180                 185                 190         


Val Ala Arg Leu Ser Ala Arg Pro Lys Ile Lys Ala Phe Leu Ala Ser 
        195                 200                 205             


Pro Glu His Val Asn Arg Pro Ile Asn Gly Asn Gly Lys Gly His His 
    210                 215                 220                 


His His His His 
225             


