                         SEQUENCE LISTING

<110>  REGENERON PHARMACEUTICALS, INC.
 
<120>  METHODS FOR IDENTIFICATION OF SCRAMBLED DISULFIDES IN 
       BIOMOLECULES

<130>  10870WO01


<150>  63/128,146
<151>  2020-12-20

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide of mAb2

<400>  1

Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10          


<210>  2
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide of mAb2

<400>  2

Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
1               5                   10                  


<210>  3
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb1

<400>  3

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
1               5                   10                  15      


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb1

<400>  4

Asp Thr Leu Met Ile Ser Arg 
1               5           


<210>  5
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb1

<400>  5

Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
1               5                   10  


<210>  6
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb1

<400>  6

Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
1               5                   10                  15      


His Asn His Tyr Thr Gln Lys 
            20              


<210>  7
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb2

<400>  7

Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys 
1               5                   10                  


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb2

<400>  8

Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Arg 
1               5                   10      


<210>  9
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb2

<400>  9

Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
1               5                   10      


<210>  10
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb2

<400>  10

Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
1               5                   10                  15      


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            20                  25                  30          


Lys 
    


<210>  11
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb2

<400>  11

Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
1               5                   10                  15      


His Asn His Tyr Thr Gln Lys 
            20              


<210>  12
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb2

<400>  12

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg 
            20                  


<210>  13
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb2

<400>  13

Val Glu Ala Glu Asp Val Gly Phe Tyr Tyr Cys Met Gln Ala Leu Gln 
1               5                   10                  15      


Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
            20                  25      


<210>  14
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb2

<400>  14

Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
1               5                   10                  15      


<210>  15
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb2

<400>  15

Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
1               5                   10                  15      


Lys 
    


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb2

<400>  16

Ser Phe Asn Arg Gly Glu Cys 
1               5           


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb2

<400>  17

Asp Tyr Ala Met Thr Trp Val Arg 
1               5               


<210>  18
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb2

<400>  18

Ser Gly Gln Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg 
1               5                   10                  15  


<210>  19
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb2

<400>  19

Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
1               5                   10                  15      


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
            20                  25                  30          


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
        35                  40                  45              


Lys 
    


<210>  20
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb2

<400>  20

Ala Asp Tyr Glu Lys 
1               5   


<210>  21
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb2

<400>  21

Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
1               5                   10                  15      


Pro Glu Asn Asn Tyr Lys 
            20          


<210>  22
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb2

<400>  22

Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
1               5                   10                  15      


Arg 
    


<210>  23
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb5

<400>  23

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg 
            


<210>  24
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb5

<400>  24

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg 
        


<210>  25
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb5

<400>  25

Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10          


<210>  26
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb5

<400>  26

Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
1               5                   10                  


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb5

<400>  27

Ala Leu Pro Ala Pro Ile Glu Lys 
1               5               


<210>  28
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb5

<400>  28

Asp Glu Leu Thr Lys 
1               5   


<210>  29
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb5

<400>  29

Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
1               5                   10                  15      


Lys 
    


<210>  30
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb5

<400>  30

Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Ser Ser Tyr Ala Met Asn 
1               5                   10                  15      


Trp Val Arg 
            


<210>  31
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb5

<400>  31

Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
1               5                   10                  


<210>  32
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb5

<400>  32

Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
1               5                   10                  15      


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
            20                  25                  30          


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
        35                  40                  45              


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    50                  55                  60              


<210>  33
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb5

<400>  33

Ser Cys Asp Lys 
1               


<210>  34
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb5

<400>  34

Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
1               5                   10                  15      


Glu Val Lys 
            


<210>  35
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb5

<400>  35

Val Thr Ile Thr Cys Arg 
1               5       


<210>  36
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb5

<400>  36

Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
1               5                   10                  15      


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser 
            20                  25                  30          


Thr Leu Thr Phe Gly Gln Gly Thr Arg 
        35                  40      


<210>  37
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb2

<400>  37

Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
1               5                   10  


<210>  38
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb2

<400>  38

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
1               5                   10                  15      


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb2

<400>  39

Asp Thr Leu Met Ile Ser Arg 
1               5           


<210>  40
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb5

<400>  40

Ala Asp Tyr Glu Lys 
1               5   


<210>  41
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb5

<400>  41

Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
1               5                   10      


<210>  42
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb5

<400>  42

Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
1               5                   10  


<210>  43
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb5

<400>  43

Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
1               5                   10                  15      


His Asn His Tyr Thr Gln Lys 
            20              


<210>  44
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb5

<400>  44

Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
1               5                   10                  15      


<210>  45
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb5

<400>  45

Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
1               5                   10                  15      


Lys 
    


<210>  46
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb2

<400>  46

Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly 
1               5                   10                  15      


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25          


<210>  47
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of mAb5

<400>  47

Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
1               5                   10                  15      


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25      


