                         SEQUENCE LISTING

<110>  IDEXX LABORATORIES, INC.
       BOUCHER, Joshua
       Madrid, Clever
       Buch, Jesse
       Mestek, Anton
 
<120>  Rocky Mountain Spotted Fever Detection and Treatment

<130>  331721-000066

<150>  63/126,756
<151>  2020-12-17

<160>  48    

<170>  PatentIn version 3.5

<210>  1
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDX6


<220>
<221>  X
<222>  (9)..(9)
<223>  The X at position 9 can be E or A

<220>
<221>  X
<222>  (34)..(34)
<223>  The X at position 34 can be G or S

<400>  1

Cys Asp Tyr Lys Lys Ser Leu Leu Xaa Leu Arg Ser Ser Asp Glu Asp 
1               5                   10                  15      


Asp Gln Gly Tyr Ala Thr Gly Tyr Thr Thr Asp Glu Glu Glu Leu Glu 
            20                  25                  30          


Glu Xaa Asn Ser Thr Thr Gly Glu Glu Leu Lys Lys Asp Ile Ser Asp 
        35                  40                  45              


<210>  2
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDX7


<220>
<221>  X
<222>  (24)..(24)
<223>  The X at position 24 can be G or S

<400>  2

Cys Ser Ser Asp Glu Asp Asp Gln Gly Tyr Ala Thr Gly Tyr Thr Thr 
1               5                   10                  15      


Asp Glu Glu Glu Leu Glu Glu Xaa Asn Ser Thr Thr Gly Glu Glu Leu 
            20                  25                  30          


Lys Lys Asp Ile Ser Asp 
        35              


<210>  3
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TDX1779

<400>  3

Met Asp Trp Thr Trp Arg Val Phe Phe Leu Leu Ala Leu Ala Thr Gly 
1               5                   10                  15      


Val His Ser Cys Asp Tyr Lys Lys Ser Leu Leu Glu Leu Arg Ser Ser 
            20                  25                  30          


Asp Glu Asp Asp Gln Gly Tyr Ala Thr Gly Tyr Thr Thr Asp Glu Glu 
        35                  40                  45              


Glu Leu Glu Glu Ser Asn Ser Thr Thr Gly Glu Glu Leu Lys Lys Asp 
    50                  55                  60                  


Ile Ser Asp Asp Tyr Lys Lys Ser Leu Leu Glu Leu Arg Ser Ser Asp 
65                  70                  75                  80  


Glu Asp Asp Gln Gly Tyr Ala Thr Gly Tyr Thr Thr Asp Glu Glu Glu 
                85                  90                  95      


Leu Glu Glu Ser Asn Ser Thr Thr Gly Glu Glu Leu Lys Lys Asp Ile 
            100                 105                 110         


Ser Asp Asp Tyr Lys Lys Ser Leu Leu Glu Leu Arg Ser Ser Asp Glu 
        115                 120                 125             


Asp Asp Gln Gly Tyr Ala Thr Gly Tyr Thr Thr Asp Glu Glu Glu Leu 
    130                 135                 140                 


Glu Glu Ser Asn Ser Thr Thr Gly Glu Glu Leu Lys Lys Asp Ile Ser 
145                 150                 155                 160 


Asp Ala Ala Ala His His His His His His His His 
                165                 170         


<210>  4
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TDX1780

<400>  4

Met Asp Trp Thr Trp Arg Val Phe Phe Leu Leu Ala Leu Ala Thr Gly 
1               5                   10                  15      


Val His Ser Cys Asp Tyr Lys Lys Ser Leu Leu Glu Leu Arg Ser Ser 
            20                  25                  30          


Asp Glu Asp Asp Gln Gly Tyr Ala Thr Gly Tyr Thr Thr Asp Glu Glu 
        35                  40                  45              


Glu Leu Glu Glu Ser Asn Ser Thr Thr Gly Glu Glu Leu Lys Lys Asp 
    50                  55                  60                  


Ile Ser Asp Asp Tyr Lys Lys Ser Leu Leu Glu Leu Arg Ser Ser Asp 
65                  70                  75                  80  


Glu Asp Asp Gln Gly Tyr Ala Thr Gly Tyr Thr Thr Asp Glu Glu Glu 
                85                  90                  95      


Leu Glu Glu Ser Asn Ser Thr Thr Gly Glu Glu Leu Lys Lys Asp Ile 
            100                 105                 110         


Ser Asp Asp Tyr Lys Lys Ser Leu Leu Glu Leu Arg Ser Ser Asp Glu 
        115                 120                 125             


Asp Asp Gln Gly Tyr Ala Thr Gly Tyr Thr Thr Asp Glu Glu Glu Leu 
    130                 135                 140                 


Glu Glu Ser Asn Ser Thr Thr Gly Glu Glu Leu Lys Lys Asp Ile Ser 
145                 150                 155                 160 


Asp Asp Tyr Lys Lys Ser Leu Leu Glu Leu Arg Ser Ser Asp Glu Asp 
                165                 170                 175     


Asp Gln Gly Tyr Ala Thr Gly Tyr Thr Thr Asp Glu Glu Glu Leu Glu 
            180                 185                 190         


Glu Ser Asn Ser Thr Thr Gly Glu Glu Leu Lys Lys Asp Ile Ser Asp 
        195                 200                 205             


Asp Tyr Lys Lys Ser Leu Leu Glu Leu Arg Ser Ser Asp Glu Asp Asp 
    210                 215                 220                 


Gln Gly Tyr Ala Thr Gly Tyr Thr Thr Asp Glu Glu Glu Leu Glu Glu 
225                 230                 235                 240 


Ser Asn Ser Thr Thr Gly Glu Glu Leu Lys Lys Asp Ile Ser Asp Ala 
                245                 250                 255     


Ala Ala His His His His His His His His 
            260                 265     


<210>  5
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDX21

<400>  5

Met Leu Phe Asp Lys Ile Lys Ser Lys Arg Lys Gly Lys Ser Met Ser 
1               5                   10                  15      


Asn Ile Asn Ala Lys Phe Tyr Ile Pro Leu Val Ser Leu Leu Gly Val 
            20                  25                  30          


Phe Ile Tyr Leu Leu Asn 
        35              


<210>  6
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDX39

<400>  6

Cys Lys Glu Val Leu Tyr Lys Ser Ala Tyr Ser Leu Thr Val Tyr Ile 
1               5                   10                  15      


Ser Ile Phe Leu Val Gln Lys Val Tyr Gly Asn Asn Gly Ser Val Arg 
            20                  25                  30          


Ala Leu Lys Asn Phe 
        35          


<210>  7
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDX40

<400>  7

Cys Leu Phe Asp Lys Ile Lys Ser Lys Arg Lys Gly Lys Ser Met Ser 
1               5                   10                  15      


Asn Ile Asn Ala Lys Phe Tyr Ile Pro Leu Val Ser Leu Leu Gly Val 
            20                  25                  30          


Phe Ile Tyr Leu Leu Asn 
        35              


<210>  8
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The Rickettsia vitamin uptake transporter VUT family protein

<400>  8

Met Leu Phe Asp Lys Ile Lys Ser Lys Arg Lys Gly Lys Cys Met Ser 
1               5                   10                  15      


Asn Ile Asn Ala Lys Phe Tyr Ile Pro Leu Val Ser Leu Leu Gly Val 
            20                  25                  30          


Phe Ile Tyr Leu Leu Asn Cys Phe Asn Lys Ile Ser Gln Cys Ser Leu 
        35                  40                  45              


Val Phe Val Phe Leu Ala Ile Thr Thr Asn Ile Ile Ser Glu Leu Tyr 
    50                  55                  60                  


Gly Arg Lys Arg Ala Leu Ile Ala Val Ala Leu Cys Ile Ile Val Ser 
65                  70                  75                  80  


Phe Gly Leu Leu Trp Asn Phe Asn Tyr Tyr Ile His Gly Arg Val Ile 
                85                  90                  95      


Lys Gly Val Val Phe Ala Ser Phe Val Ser Val Leu Leu Ser Thr Tyr 
            100                 105                 110         


Cys Ser Thr Ser Ile Phe Ser Gln Leu Lys Pro Arg Cys Ser Leu Asn 
        115                 120                 125             


Thr Arg Asn Phe Ala Ser Leu Ile Met Cys Ala Val Val Asp Gly Ile 
    130                 135                 140                 


Val Met Ser Gly Phe Phe Val Asn Val Phe Ser Thr Ser Lys Val Leu 
145                 150                 155                 160 


Ser Ile Phe Tyr Lys Glu Val Leu Tyr Lys Cys Ala Tyr Ser Leu Thr 
                165                 170                 175     


Val Tyr Ile Cys Ile Phe Leu Val Gln Lys Val Tyr Gly Asn Asn Gly 
            180                 185                 190         


Ser Val Arg Ala Leu Lys Asn Phe 
        195                 200 


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA epitope tag

<400>  9

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Cys 
1               5                   10  


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  myc epitope tag

<400>  10

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Cys 
1               5                   10      


<210>  11
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V5 epitope tag

<400>  11

Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210>  12
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E-tag epitope tag

<400>  12

Gly Ala Pro Val Pro Tyr Pro Asp Pro Leu Glu Pro Arg 
1               5                   10              


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VSV-g epitope tag

<400>  13

Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
1               5                   10      


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6xHis epitope tag

<400>  14

His His His His His His His 
1               5           


<210>  15
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSV epitope tag

<400>  15

Gln Pro Glu Leu Ala Pro Glu Asp Pro Glu Asp Cys 
1               5                   10          


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLAG epitope tag

<400>  16

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  17
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SCA2 auto chaperone region from Rickettsia rickettsii species

<400>  17

Thr Ala Leu Ser Pro Arg Leu Leu Ser Ser Asn Asp Ser Lys Asn Asp 
1               5                   10                  15      


Lys Ser Ser Asp Tyr Lys Lys Ser Leu Leu Glu Leu Arg Ser Ser Asp 
            20                  25                  30          


Glu Asp Asp Gln Gly Tyr Ala Thr Gly Tyr Thr Thr Asp Glu Glu Glu 
        35                  40                  45              


Leu Glu Glu Ser Asn Ser Thr Thr Gly Glu Glu Leu Lys Lys Asp Ile 
    50                  55                  60                  


Ser Asp Tyr Lys Lys Ser Leu Leu Ala 
65                  70              


<210>  18
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SCA2 auto chaperone region from Rickettsia conorii, Rickettsia 
       africae, Rickettsia japonica, and Rickettsia parkeri species

<400>  18

Thr Ala Leu Ser Pro Arg Leu Leu Ser Ser Asn Asp Ser Lys Asn Asp 
1               5                   10                  15      


Lys Ser Ser Asp Asp Lys Lys Ser Leu Leu Ala 
            20                  25          


<210>  19
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SCA2 auto chaperone region from Rickettsia philipii species

<400>  19

Thr Ala Leu Ser Pro Arg Leu Leu Ser Ser Asn Asp Ser Lys Asn Asp 
1               5                   10                  15      


Lys Ser Ser Asp Tyr Lys Lys Ser Leu Leu Ala 
            20                  25          


<210>  20
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SCA2 auto chaperone region from Rickettsia massiliae species

<400>  20

Thr Val Leu Ser Pro Arg Leu Leu Cys Ser Asn Asp Ser Lys Asn Asp 
1               5                   10                  15      


Lys Ser Ser Asp Asp Lys Lys Ser Leu Leu Ala 
            20                  25          


<210>  21
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SCA2 auto chaperone region from Rickettsia felis species

<400>  21

Thr Ala Leu Ser Pro Arg Leu Leu Ser Ser Asn Asp Ser Lys Asn Asp 
1               5                   10                  15      


Lys Ser Ser Asp Asp Lys Lys Ser Leu Leu Val 
            20                  25          


<210>  22
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SCA2 auto chaperone region from Rickettsia typhi species

<400>  22

Asn Cys Leu Asp Thr Glu Glu Glu Val Val His Lys Glu Lys Ile Ala 
1               5                   10                  15      


Asp 
    


<210>  23
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SCA2 auto chaperone region from Rickettsia bellii species

<400>  23

Ile Arg Ala His Pro Asp Leu Phe Pro Thr Val Phe Asn Asp Pro Asp 
1               5                   10                  15      


Thr Leu Ala 
            


<210>  24
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  secretory signal sequence

<400>  24

Met Asp Trp Thr Trp Arg Val Phe Phe Leu Leu Ala Leu Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  25
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  secretory signal sequence

<400>  25

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala 
            


<210>  26
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  secretory signal sequence

<400>  26

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala 
            20          


<210>  27
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  secretory signal sequence

<400>  27

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Trp Leu Gln Glu Gly Ser Ala 
            20                  25  


<210>  28
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  secretory signal sequence

<400>  28

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


<210>  29
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  secretory signal sequence

<400>  29

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg 
            20                  25                  30          


Phe Arg Arg 
        35  


<210>  30
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  secretory signal sequence

<400>  30

Met Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr 
1               5                   10                  15      


Pro Val Lys Thr Ala 
            20      


<210>  31
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  secretory signal sequence

<400>  31

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala 
            20      


<210>  32
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  secretory signal sequence

<400>  32

Met Lys Lys Ile Trp Leu Ala Leu Ala Gly Leu Val Leu Ala Phe Ser 
1               5                   10                  15      


Ala Ser Ala 
            


<210>  33
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  secretory signal sequence

<400>  33

Met Arg Val Leu Leu Phe Leu Leu Ser Leu Phe Met Leu Pro Ala Phe 
1               5                   10                  15      


Ser 
    


<210>  34
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  secretory signal sequence

<400>  34

Met Ser Leu Ser Arg Arg Gln Phe Ile Gln Ala Ser Gly Ile Ala Leu 
1               5                   10                  15      


Cys Ala Gly Ala Val Pro Leu Lys Ala Ser Ala 
            20                  25          


<210>  35
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  secretory signal sequence

<400>  35

Met Asn Asn Asn Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala 
1               5                   10                  15      


Gln Leu Gly Gly Leu Thr Val Ala Gly Met Leu Gly Pro Ser Leu Leu 
            20                  25                  30          


Thr Pro Arg Arg Ala Thr Ala 
        35                  


<210>  36
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  secretory signal sequence

<400>  36

Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala 
            20                  25                  30  


<210>  37
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  secretory signal sequence

<400>  37

Met Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu 
1               5                   10                  15      


Cys Cys Leu Val Pro Val Ser Leu Ala 
            20                  25  


<210>  38
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  secretory signal sequence

<400>  38

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Ser Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg 
        35                  40                  45      


<210>  39
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  secretory signal sequence

<400>  39

Met Lys Gly Ser Leu Leu Leu Leu Leu Val Ser Asn Leu Leu Leu Cys 
1               5                   10                  15      


Gln Ser Val Ala Pro 
            20      


<210>  40
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  secretory signal sequence

<400>  40

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg 
            20                  


<210>  41
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  secretory signal sequence

<400>  41

Met Val Ser Leu Lys Ile Lys Lys Leu Leu Leu Val Ser Leu Leu Asn 
1               5                   10                  15      


Ala Ile Glu Ala Tyr Ser Asn Asp Thr Ile Tyr Ser Thr Ser Tyr Asn 
            20                  25                  30          


Asn Gly Ile Glu Ser Thr Pro Ser Tyr Ser Thr Ser Ala Ile Ser Ser 
        35                  40                  45              


Thr Gly Ser Ser Asn Lys Glu Asn Ala Ile Thr Ser Ser Ser Glu Thr 
    50                  55                  60                  


Thr Thr Met Ala Gly Asp Tyr Gly Glu Ser Gly Ser Thr Thr Ile Met 
65                  70                  75                  80  


Asp Glu Gln Glu Thr Gly Thr Ser Ser Gln Tyr Ile Ser Val Thr Thr 
                85                  90                  95      


Thr Thr Gln 
            


<210>  42
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  secretory signal sequence

<400>  42

Asn Gly Gly Asn Met Ala Ile Lys Lys Ala Ser Leu Ile Ala Leu Leu 
1               5                   10                  15      


Pro Leu Phe Thr Ala Ala Ala Ala Ala Ala Thr Asp Ala Glu Thr Ser 
            20                  25                  30          


Asn Glu Ser Gly Ser Ser Ser His Leu Lys Ser 
        35                  40              


<210>  43
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  secretory signal sequence

<400>  43

Met Lys Phe Thr Ser Val Leu Ala Phe Phe Leu Ala Thr Leu Thr Ala 
1               5                   10                  15      


Ser Ala Thr Phe Leu Tyr Lys Arg Gln Asn Val Thr Ser Gly Gly Gly 
            20                  25                  30          


Thr Val Pro Ile Ile Thr Gly Gly Pro Ala Val Ser Gly Ser Gln Ser 
        35                  40                  45              


Asn Val Thr Thr Thr Thr Leu Phe Asn Ser Thr Ser Thr Leu Asn Ile 
    50                  55                  60                  


Thr Gln Leu Tyr Gln Ile Ala Thr Asp Val Asn Asp Thr Leu Gln Ser 
65                  70                  75                  80  


Glu Ser Ser Ser 
                


<210>  44
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  secretory signal sequence

<400>  44

Met Gln Phe Pro Phe Ala Cys Leu Leu Ser Thr Leu Val Ile Ser Gly 
1               5                   10                  15      


Ser Leu Ala Arg Ala Ser Pro Phe Asp Phe Ile Phe Gly Asn Gly Thr 
            20                  25                  30          


Gln Gln Ala Gln Ser Gln Ser Glu Ser Gln Gly Gln Val Ser Phe Thr 
        35                  40                  45              


Asn Glu Ala Ser Gln Asp Ser Ser Thr Thr Ser Leu Val Thr Ala Tyr 
    50                  55                  60                  


Ser Gln Gly Val His Ser His Gln Ser Ala Thr Ile Val Ser Ala Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Pro Ser Thr Trp Tyr Asp Ala Ser Ser Thr Ser Gln 
                85                  90                  95      


Thr Ser Val Ser 
            100 


<210>  45
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  secretory signal sequence

<400>  45

Met Gln Phe Lys Asn Ala Leu Thr Ala Thr Ala Ile Leu Ser Ala Ser 
1               5                   10                  15      


Ala Leu Ala Ala Asn Ser Thr Thr Ser Ile Pro Ser Ser Cys Ser Ile 
            20                  25                  30          


Gly Thr Ser Ala Thr Ala Thr Ala Gln Ala Asp Leu Asp Lys Ile Ser 
        35                  40                  45              


Gln Cys Ser Thr Ile Val Gly Asn Leu Thr Ile Thr Gly Asp Leu Gly 
    50                  55                  60                  


Ser Ala Ala Leu Ala Ser Ile Gln Glu Ile Asp Gly Ser Leu Thr Ile 
65                  70                  75                  80  


Phe Asn Ser Ser Ser Leu Ser Ser Phe Ser Ala Asp Ile Lys Lys Ile 
                85                  90                  95      


<210>  46
<211>  77
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  secretory signal sequence

<400>  46

Met Lys Phe Ser Thr Leu Ser Thr Val Ala Ala Ile Ala Ala Phe Ala 
1               5                   10                  15      


Ser Ala Asp Ser Thr Ser Asp Gly Val Thr Tyr Val Asp Val Thr Thr 
            20                  25                  30          


Thr Pro Gln Ser Thr Thr Ser Met Val Ser Thr Val Lys Thr Thr Ser 
        35                  40                  45              


Thr Pro Tyr Thr Thr Ser Thr Ile Ala Thr Leu Ser Thr Lys Ser Ile 
    50                  55                  60                  


Ser Ser Gln Ala Asn Thr Thr Thr His Glu Ile Ser Thr 
65                  70                  75          


<210>  47
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  secretory signal sequence

<400>  47

Met Phe Val His Arg Leu Trp Thr Leu Ala Phe Pro Phe Leu Val Glu 
1               5                   10                  15      


Ile Ser Lys Ala Ser Gln Leu Glu Asn Ile Lys Ser Leu Leu Asp Ile 
            20                  25                  30          


Glu Asp Asn Val Leu Pro Asn Leu Asn Ile Ser Gln Asn Asn Ser Asn 
        35                  40                  45              


Ala Val Gln Ile Leu Gly Gly Val Asp Ala Leu Ser Phe Tyr Glu Tyr 
    50                  55                  60                  


Thr Gly Gln Gln Asn Phe Thr Lys Glu Ile Gly Pro Glu Thr Ser Ser 
65                  70                  75                  80  


His Gly Leu Val Tyr Tyr Ser Asn Asn Thr Tyr Ile Gln Leu Glu Asp 
                85                  90                  95      


Ala Ser Asp Asp 
            100 


<210>  48
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  secretory signal sequence

<400>  48

Met Lys Leu Gln Ser Leu Leu Val Ser Ala Ala Val Leu Thr Ser Leu 
1               5                   10                  15      


Thr Glu Asn Val Asn Ala Met Ser Pro Asn Asn Ser Tyr Val Pro Ala 
            20                  25                  30          


Asn Val Thr Cys Asp Asp Asp Ile Asn Leu Val Arg Glu Ala Ser Gly 
        35                  40                  45              


Leu Ser Asp Asn Glu Tyr Glu Met Leu Lys Lys Arg Asp Ala Tyr Thr 
    50                  55                  60                  


Lys Glu 
65      


