                               SEQUENCE LISTING

<110> MERCK SHARP & DOHME CORP.

<120> SYNTHESIS OF ANTIVIRAL NUCLEOSIDES

<130> 25183-WO-PCT

<140>
<141>

<150> 63/192,912
<151> 2021-05-25

<150> 63/182,171
<151> 2021-04-30

<150> 63/127,484
<151> 2020-12-18

<160> 54    

<170> PatentIn version 3.5

<210> 1
<211> 399
<212> PRT
<213> Klebsiella sp.

<400> 1
Met Ser Gln Tyr His Thr Phe Thr Ala His Asp Ala Val Ala Tyr Ala 
1               5                   10                  15      


Gln Gln Phe Ala Gly Ile Asp Asn Pro Ser Glu Leu Val Ser Ala Gln 
            20                  25                  30          


Glu Val Gly Asp Gly Asn Leu Asn Leu Val Phe Lys Val Phe Asp Arg 
        35                  40                  45              


Gln Gly Val Ser Arg Ala Ile Val Lys Gln Ala Leu Pro Tyr Val Arg 
    50                  55                  60                  


Cys Val Gly Glu Ser Trp Pro Leu Thr Leu Asp Arg Ala Arg Leu Glu 
65                  70                  75                  80  


Ala Gln Thr Leu Val Ala His Tyr Gln His Ser Pro Gln His Thr Val 
                85                  90                  95      


Lys Ile His His Phe Asp Pro Glu Leu Ala Val Met Val Met Glu Asp 
            100                 105                 110         


Leu Ser Asp His Arg Ile Trp Arg Gly Glu Leu Ile Ala Asn Val Tyr 
        115                 120                 125             


Tyr Pro Gln Ala Ala Arg Gln Leu Gly Asp Tyr Leu Ala Gln Val Leu 
    130                 135                 140                 


Phe His Thr Ser Asp Phe Tyr Leu His Pro His Glu Lys Lys Ala Gln 
145                 150                 155                 160 


Val Ala Gln Phe Ile Asn Pro Ala Met Cys Glu Ile Thr Glu Asp Leu 
                165                 170                 175     


Phe Phe Asn Asp Pro Tyr Gln Ile His Glu Arg Asn Asn Tyr Pro Ala 
            180                 185                 190         


Glu Leu Glu Ala Asp Val Ala Ala Leu Arg Asp Asp Ala Gln Leu Lys 
        195                 200                 205             


Leu Ala Val Ala Ala Leu Lys His Arg Phe Phe Ala His Ala Glu Ala 
    210                 215                 220                 


Leu Leu His Gly Asp Ile His Ser Gly Ser Ile Phe Val Ala Glu Gly 
225                 230                 235                 240 


Ser Leu Lys Ala Ile Asp Ala Glu Phe Gly Tyr Phe Gly Pro Ile Gly 
                245                 250                 255     


Phe Asp Ile Gly Thr Ala Ile Gly Asn Leu Leu Leu Asn Tyr Cys Gly 
            260                 265                 270         


Leu Pro Gly Gln Leu Gly Ile Arg Asp Ala Ala Ala Ala Arg Glu Gln 
        275                 280                 285             


Arg Leu Asn Asp Ile His Gln Leu Trp Thr Thr Phe Ala Glu Arg Phe 
    290                 295                 300                 


Gln Ala Leu Ala Ala Glu Lys Thr Arg Asp Ala Ala Leu Ala Tyr Pro 
305                 310                 315                 320 


Gly Tyr Ala Ser Ala Phe Leu Lys Lys Val Trp Ala Asp Ala Val Gly 
                325                 330                 335     


Phe Cys Gly Ser Glu Leu Ile Arg Arg Ser Val Gly Leu Ser His Val 
            340                 345                 350         


Ala Asp Ile Asp Thr Ile Gln Asp Asp Ala Met Arg His Glu Cys Leu 
        355                 360                 365             


Arg His Ala Ile Thr Leu Gly Arg Ala Leu Ile Val Leu Ala Glu Arg 
    370                 375                 380                 


Ile Asp Ser Val Asp Glu Leu Leu Ala Arg Val Arg Gln Tyr Ser 
385                 390                 395                 


<210> 2
<211> 1200
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Corresponding DNA seq 1

<400> 2
atgagccagt atcatacctt caccgcgcat gatgcggtgg cgtatgcgca gcaatttgcg       60

ggcattgata acccgagcga gctggttagc gcgcaagaag ttggtgacgg caacctgaac      120

ctggtgttca aggtttttga tcgtcagggt gtgagccgtg cgatcgttaa acaagcgctg      180

ccgtacgtgc gttgcgttgg tgaaagctgg ccgctgaccc tggaccgtgc gcgtctggaa      240

gcgcagaccc tggtggcgca ctatcagcac agcccgcaac acaccgttaa gatccaccac      300

ttcgatccgg agctggcggt gatggttatg gaagacctga gcgatcaccg tatttggcgt      360

ggtgagctga tcgcgaacgt gtactatccg caggcggcgc gtcaactggg tgactacctg      420

gcgcaggttc tgttccacac cagcgatttt tatctgcacc cgcacgagaa gaaagcgcag      480

gtggcgcaat tcattaaccc ggcgatgtgc gagatcaccg aagacctgtt ctttaacgat      540

ccgtaccaga ttcacgaacg taacaactat ccggcggagc tggaagcgga tgtggcggcg      600

ctgcgtgatg atgcgcaact gaagctggcg gttgcggcgc tgaaacaccg tttctttgcg      660

catgcggagg cgctgctgca tggtgacatt cacagcggca gcatcttcgt tgcggagggt      720

agcctgaagg cgatcgacgc ggaattcggt tactttggcc cgatcggttt tgatattggt      780

accgcgatcg gcaacctgct gctgaactat tgcggtctgc cgggtcaact gggtattcgt      840

gatgcggcgg cggcgcgtga acagcgtctg aacgatatcc accaactgtg gaccaccttc      900

gcggagcgtt ttcaagcgct ggcggcggaa aagacccgtg acgcggcgct ggcgtacccg      960

ggttatgcga gcgcgttcct gaagaaagtg tgggcggatg cggttggttt ttgcggcagc     1020

gagctgattc gtcgtagcgt gggcctgagc cacgttgcgg acatcgatac cattcaggac     1080

gatgcgatgc gtcacgaatg cctgcgtcac gcgatcaccc tgggtcgtgc gctgattgtt     1140

ctggcggagc gtatcgacag cgtggatgaa ctgctggcgc gtgttcgtca atacagctaa     1200


<210> 3
<211> 407
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> MTR kinase (rd2BB)

<400> 3
Met Ser Gln Tyr His Thr Phe Thr Ala His Asp Ala Val Ala Tyr Ala 
1               5                   10                  15      


Gln Gln Phe Ala Gly Ile Asp Asn Pro Ser Glu Leu Val Ser Ala Gln 
            20                  25                  30          


Glu Val Gly Asp Gly Asn Leu Asn Leu Val Phe Lys Val Phe Asp Arg 
        35                  40                  45              


Gln Gly Val Ser Arg Ala Ile Val Lys Gln Ala Leu Pro Tyr Val Arg 
    50                  55                  60                  


Cys Val Gly Glu Ser Trp Pro Leu Thr Leu Asp Arg Ala Arg His Glu 
65                  70                  75                  80  


Ala Gln Thr Leu Val Ala His Tyr Gln His Ser Pro Gln His Thr Val 
                85                  90                  95      


Lys Ile His His Phe Asp Pro Glu Leu Ala Val Met Val Met Glu Asp 
            100                 105                 110         


Leu Ser Asp His Arg Ile Trp Arg Gly Glu Leu Ile Ala Asn Val Tyr 
        115                 120                 125             


Tyr Pro Gln Ala Ala Arg Gln Leu Gly Asp Tyr Leu Ala Gln Val Leu 
    130                 135                 140                 


Phe His Thr Ser Asp Phe Tyr Leu His Pro His Glu Lys Lys Ala Gln 
145                 150                 155                 160 


Val Ala Gln Phe Ile Asn Pro Ala Met Cys Glu Ile Thr Glu Asp Leu 
                165                 170                 175     


Phe Phe Asn Asp Pro Tyr Gln Ile His Glu Arg Asn Asn Tyr Pro Ala 
            180                 185                 190         


Glu Leu Glu Ala Asp Val Ala Ala Leu Arg Asp Asp Ala Gln Leu Lys 
        195                 200                 205             


Leu Ala Val Ala Ala Leu Lys His Arg Phe Phe Ala His Ala Glu Ala 
    210                 215                 220                 


Leu Leu His Gly Asp Ile His Ser Gly Ser Ile Phe Val Ala Glu Gly 
225                 230                 235                 240 


Ser Leu Lys Ala Ile Asp Ala Glu Phe Gly Tyr Phe Gly Pro Ile Gly 
                245                 250                 255     


Phe Asp Ile Gly Thr Ala Ile Gly Asn Leu Leu Leu Asn Tyr Cys Gly 
            260                 265                 270         


Leu Pro Gly Gln Leu Gly Ile Arg Asp Ala Ala Ala Ala Arg Glu Gln 
        275                 280                 285             


Arg Leu Asn Asp Ile His Gln Leu Trp Thr Thr Phe Ala Glu Arg Phe 
    290                 295                 300                 


Gln Ala Leu Ala Ala Glu Lys Thr Arg Asp Ala Ala Leu Ala Tyr Pro 
305                 310                 315                 320 


Gly Tyr Ala Ser Ala Phe Leu Lys Lys Val Trp Ala Asp Ala Val Gly 
                325                 330                 335     


Phe Cys Gly Ser Glu Leu Ile Arg Arg Ser Val Gly Leu Ser His Val 
            340                 345                 350         


Ala Asp Ile Asp Thr Ile Gln Asp Asp Ala Met Arg His Glu Cys Leu 
        355                 360                 365             


Arg His Ala Ile Thr Leu Gly Arg Ala Leu Ile Val Leu Ala Glu Arg 
    370                 375                 380                 


Ile Asp Ser Val Asp Glu Leu Leu Ala Arg Val Arg Gln Tyr Ser Leu 
385                 390                 395                 400 


Glu His His His His His His 
                405         


<210> 4
<211> 1224
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> corresponding DNA seq 3

<400> 4
atgagccagt atcatacctt caccgcgcat gatgcggtgg cgtatgcgca gcaatttgcg       60

ggcattgata acccgagcga gctggttagc gcgcaagaag ttggtgacgg caacctgaac      120

ctggtgttca aggtttttga tcgtcagggt gtgagccgtg cgatcgttaa acaagcgctg      180

ccgtacgtgc gttgcgttgg tgaaagctgg ccgctgaccc tggaccgtgc gcgtcatgaa      240

gcgcagaccc tggtggcgca ctatcagcac agcccgcaac acaccgttaa gatccaccac      300

ttcgatccgg agctggcggt gatggttatg gaagacctga gcgatcaccg tatttggcgt      360

ggtgagctga tcgcgaacgt gtactatccg caggcggcgc gtcaactggg tgactacctg      420

gcgcaggttc tgttccacac cagcgatttt tatctgcacc cgcacgagaa gaaagcgcag      480

gtggcgcaat tcattaaccc ggcgatgtgc gagatcaccg aagacctgtt ctttaacgat      540

ccgtaccaga ttcacgaacg taacaactat ccggcggagc tggaagcgga tgtggcggcg      600

ctgcgtgatg atgcgcaact gaagctggcg gttgcggcgc tgaaacaccg tttctttgcg      660

catgcggagg cgctgctgca tggtgacatt cacagcggca gcatcttcgt tgcggagggt      720

agcctgaagg cgatcgacgc ggaattcggt tactttggcc cgatcggttt tgatattggt      780

accgcgatcg gcaacctgct gctgaactat tgcggtctgc cgggtcaact gggtattcgt      840

gatgcggcgg cggcgcgtga acagcgtctg aacgatatcc accaactgtg gaccaccttc      900

gcggagcgtt ttcaagcgct ggcggcggaa aagacccgtg acgcggcgct ggcgtacccg      960

ggttatgcga gcgcgttcct gaagaaagtg tgggcggatg cggttggttt ttgcggcagc     1020

gagctgattc gtcgtagcgt gggcctgagc cacgttgcgg acatcgatac cattcaggac     1080

gatgcgatgc gtcacgaatg cctgcgtcac gcgatcaccc tgggtcgtgc gctgattgtt     1140

ctggcggagc gtatcgacag cgtggatgaa ctgctggcgc gtgttcgtca atacagcctc     1200

gagcaccacc accaccacca ctga                                            1224


<210> 5
<211> 407
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> MTR kinase (rd3BB)

<400> 5
Met Ser Gln Tyr His Thr Phe Thr Ala His Asp Ala Val Ala Tyr Ala 
1               5                   10                  15      


Gln Gln Phe Ala Gly Ile Asp Asn Pro Ser Glu Leu Val Ser Ala Gln 
            20                  25                  30          


Glu Val Gly Asp Gly Asn Leu Asn Leu Val Phe Lys Val Phe Asp Arg 
        35                  40                  45              


Gln Gly Val Ser Arg Ala Ile Val Lys Gln Ala Leu Pro Tyr Pro Arg 
    50                  55                  60                  


Cys Val Gly Glu Ser Trp Pro Leu Thr Leu Asp Arg Ala Arg His Glu 
65                  70                  75                  80  


Ala Gln Thr Leu Val Ala His Tyr Gln His Ser Pro Gln His Thr Val 
                85                  90                  95      


Lys Ile His His Phe Asp Pro Glu Leu Ala Val Met Val Met Glu Asp 
            100                 105                 110         


Leu Ser Asp His Arg Ile Trp Arg Gly Glu Leu Ile Ala Asn Val Tyr 
        115                 120                 125             


Tyr Pro Gln Ala Ala Arg Gln Leu Gly Asp Tyr Leu Ala Gln Val Leu 
    130                 135                 140                 


Phe His Thr Ser Asp Phe Tyr Leu His Pro His Glu Lys Lys Ala Gln 
145                 150                 155                 160 


Val Ala Gln Phe Ile Asn Pro Ala Met Cys Glu Ile Ser Glu Asp Leu 
                165                 170                 175     


Ile Phe Asn Asp Pro Tyr Gln Ile His Glu Arg Asn Asn Tyr Pro Ala 
            180                 185                 190         


Glu Leu Glu Ala Asp Val Ala Ala Leu Arg Asp Asp Ala Gln Leu Lys 
        195                 200                 205             


Leu Ala Val Ala Ala Leu Lys His Arg Phe Phe Ala His Ala Glu Ala 
    210                 215                 220                 


Leu Leu His Gly Asp Leu His Ser Gly Ser Ile Phe Val Ala Glu Gly 
225                 230                 235                 240 


Ser Leu Lys Ala Ile Asp Ala Glu Phe Gly Tyr Phe Gly Pro Ile Gly 
                245                 250                 255     


Phe Asp Ile Gly Thr Ala Ile Gly Asn Leu Leu Leu Asn Tyr Cys Gly 
            260                 265                 270         


Leu Pro Gly Gln Leu Gly Ile Arg Asp Ala Ala Ala Ala Arg Glu Gln 
        275                 280                 285             


Arg Leu Asn Asp Ile His Gln Leu Trp Thr Thr Phe Ala Glu Arg Phe 
    290                 295                 300                 


Gln Ala Leu Ala Ala Glu Lys Thr Arg Asp Ala Ala Leu Ala Tyr Pro 
305                 310                 315                 320 


Gly Tyr Ala Ser Ala Phe Leu Lys Lys Val Trp Ala Asp Ala Val Gly 
                325                 330                 335     


Phe Cys Gly Ser Glu Leu Ile Arg Arg Ser Val Gly Leu Ser His Val 
            340                 345                 350         


Ala Asp Ile Asp Thr Ile Gln Asp Asp Ala Met Arg His Glu Cys Leu 
        355                 360                 365             


Arg His Ala Ile Thr Leu Gly Arg Ala Leu Ile Val Leu Ala Glu Arg 
    370                 375                 380                 


Ile Asp Ser Val Asp Glu Leu Leu Ala Arg Val Arg Gln Tyr Ser Leu 
385                 390                 395                 400 


Glu His His His His His His 
                405         


<210> 6
<211> 1224
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Corresponding DNA seq 5

<400> 6
atgagccagt atcatacctt caccgcgcat gatgcggtgg cgtatgcgca gcaatttgcg       60

ggcattgata acccgagcga gctggttagc gcgcaagaag ttggtgacgg caacctgaac      120

ctggtgttca aggtttttga tcgtcagggt gtgagccgtg cgatcgttaa acaagcgctg      180

ccgtaccccc gttgcgttgg tgaaagctgg ccgctgaccc tggaccgtgc gcgtcatgaa      240

gcgcagaccc tggtggcgca ctatcagcac agcccgcaac acaccgttaa gatccaccac      300

ttcgatccgg agctggcggt gatggttatg gaagacctga gcgatcaccg tatttggcgt      360

ggtgagctga tcgcgaacgt gtactatccg caggcggcgc gtcaactggg tgactacctg      420

gcgcaggttc tgttccacac cagcgatttt tatctgcacc cgcacgagaa gaaagcgcag      480

gtggcgcaat tcattaaccc ggcgatgtgc gagatcagcg aagacctgat ttttaacgat      540

ccgtaccaga ttcacgaacg taacaactat ccggcggagc tggaagcgga tgtggcggcg      600

ctgcgtgatg atgcgcaact gaagctggcg gttgcggcgc tgaaacaccg tttctttgcg      660

catgcggagg cgctgctgca tggtgacctt cacagcggca gcatcttcgt tgcggagggt      720

agcctgaagg cgatcgacgc ggaattcggt tactttggcc cgatcggttt tgatattggt      780

accgcgatcg gcaacctgct gctgaactat tgcggtctgc cgggtcaact gggtattcgt      840

gatgcggcgg cggcgcgtga acagcgtctg aacgatatcc accaactgtg gaccaccttc      900

gcggagcgtt ttcaagcgct ggcggcggaa aagacccgtg acgcggcgct ggcgtacccg      960

ggttatgcga gcgcgttcct gaagaaagtg tgggcggatg cggttggttt ttgcggcagc     1020

gagctgattc gtcgtagcgt gggcctgagc cacgttgcgg acatcgatac cattcaggac     1080

gatgcgatgc gtcacgaatg cctgcgtcac gcgatcaccc tgggtcgtgc gctgattgtt     1140

ctggcggagc gtatcgacag cgtggatgaa ctgctggcgc gtgttcgtca atacagcctc     1200

gagcaccacc accaccacca ctga                                            1224


<210> 7
<211> 407
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> MTR kinase (rd4BB)

<400> 7
Met Ser Gln Tyr His Thr Phe Thr Ala Asp Asp Ala Val Ala Tyr Ala 
1               5                   10                  15      


Gln Gln Phe Ala Gly Ile Asp Asn Pro Ser Glu Leu Val Ser Ala Gln 
            20                  25                  30          


Glu Val Gly Asp Gly Asn Leu Asn Leu Val Phe Lys Val Phe Asp Arg 
        35                  40                  45              


Gln Gly Val Ser Arg Ala Ile Val Lys Gln Ala Leu Pro Tyr Pro Arg 
    50                  55                  60                  


Arg Val Gly Pro Ser Trp Pro Leu Thr Leu Asp Arg Ala Arg His Glu 
65                  70                  75                  80  


Ala Gln Thr Leu Val Ala His Tyr Gln His Ser Pro Gln His Thr Val 
                85                  90                  95      


Lys Ile His His Phe Asp Pro Glu Leu Ala Val Met Val Met Glu Asp 
            100                 105                 110         


Leu Ser Asp His Arg Ile Trp Arg Gly Glu Leu Ile Ala Asn Val Tyr 
        115                 120                 125             


Tyr Pro Gln Ala Ala Arg Gln Leu Gly Asp Tyr Leu Ala Gln Val Leu 
    130                 135                 140                 


Phe His Thr Ser Asp Phe Tyr Leu His Pro His Glu Lys Lys Ala Gln 
145                 150                 155                 160 


Val Ala Gln Phe Ile Asn Pro Ala Met Cys Glu Ile Ser Glu Asp Leu 
                165                 170                 175     


Val Phe Asn Asp Pro Tyr Gln Ile His Glu Arg Asn Asn Tyr Pro Ala 
            180                 185                 190         


Glu Leu Glu Ala Asp Val Ala Ala Leu Arg Asp Asp Ala Gln Leu Lys 
        195                 200                 205             


Leu Ala Val Ala Ala Leu Lys His Arg Phe Phe Ala His Ala Glu Ala 
    210                 215                 220                 


Leu Leu His Gly Asp Leu His Thr Gly Ser Ile Phe Val Ala Glu Gly 
225                 230                 235                 240 


Ser Leu Lys Val Ile Asp Ala Glu Phe Gly Tyr Phe Gly Pro Ile Gly 
                245                 250                 255     


Phe Asp Ile Gly Thr Ala Ile Gly Asn Leu Leu Leu Asn Tyr Cys Gly 
            260                 265                 270         


Leu Pro Gly Gln Leu Gly Ile Arg Asp Ala Ala Ala Ala Arg Glu Gln 
        275                 280                 285             


Arg Leu Asn Asp Ile His Gln Leu Trp Thr Thr Phe Ala Glu Arg Phe 
    290                 295                 300                 


Gln Ala Leu Ala Ala Glu Lys Thr Arg Asp Ala Ala Leu Ala Tyr Pro 
305                 310                 315                 320 


Gly Tyr Ala Ser Ala Phe Leu Lys Lys Val Trp Ala Asp Ala Val Gly 
                325                 330                 335     


Phe Cys Gly Ser Glu Leu Ile Arg Arg Ser Val Gly Leu Ala His Val 
            340                 345                 350         


Ala Asp Ile Asp Thr Ile Gln Asp Asp Ala Met Arg His Glu Cys Leu 
        355                 360                 365             


Arg Glu Ala Ile Thr Leu Gly Arg Ala Leu Ile Val Leu Ala Glu Arg 
    370                 375                 380                 


Ile Asp Ser Val Asp Glu Leu Leu Ala Arg Val Arg Gln Tyr Ser Leu 
385                 390                 395                 400 


Glu His His His His His His 
                405         


<210> 8
<211> 1224
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Corresponding DNA seq 7

<400> 8
atgagccagt atcatacctt caccgcggat gatgcggtgg cgtatgcgca gcaatttgcg       60

ggcattgata acccgagcga gctggttagc gcgcaagaag ttggtgacgg caacctgaac      120

ctggtgttca aggtttttga tcgtcagggt gtgagccgtg cgatcgttaa acaagcgctg      180

ccgtaccccc gtcgcgttgg tccgagctgg ccgctgaccc tggaccgtgc ccgtcatgaa      240

gcgcagaccc tggttgcgca ctatcagcac agcccgcaac acaccgttaa gatccaccac      300

ttcgatccgg agctggcggt gatggttatg gaagacctga gcgatcaccg tatttggcgt      360

ggtgagctga tcgcgaacgt gtactatccg caggcggcgc gtcaactggg tgactacctg      420

gcgcaggttc tgttccacac cagcgatttt tatctgcacc cgcacgagaa gaaagcgcag      480

gtggcgcaat tcattaaccc ggccatgtgc gaaatcagcg aagacctggt gtttaacgat      540

ccgtaccaga ttcacgaacg taacaactat ccggcggagc tggaagcgga tgtggcggcg      600

ctgcgtgatg atgcgcaact gaagctggcg gttgcggcgc tgaaacaccg tttctttgcg      660

catgcggagg cgctgctgca tggtgacctt cacaccggca gcatcttcgt tgcggagggt      720

agcctgaagg tgatcgacgc ggaattcggt tactttggcc cgatcggttt tgatattggt      780

accgcgatcg gcaacctgct gctgaactat tgcggtctgc cgggtcaact gggtattcgt      840

gatgcggcgg cggcgcgtga acagcgtctg aacgatatcc accaactgtg gaccaccttc      900

gcggagcgtt ttcaagcgct ggcggcggaa aagacccgtg acgcggcgct ggcgtacccg      960

ggttatgcga gcgcgttcct gaagaaagtg tgggcggatg cggttggttt ttgcggcagc     1020

gagctgattc gtcgtagcgt gggcctggcg cacgttgcgg acatcgatac cattcaggac     1080

gatgcgatgc gtcacgaatg cctgcgtgaa gcgatcaccc tgggtcgtgc gctgattgtt     1140

ctggcggagc gcatcgacag cgtggatgaa ctgctggcgc gtgttcgtca atacagcctc     1200

gagcaccacc accaccacca ctga                                            1224


<210> 9
<211> 407
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> MTR kinase F12

<400> 9
Met Ser Gln Tyr His Thr Phe Thr Ala Asp Asp Ala Val Ala Tyr Ala 
1               5                   10                  15      


Gln Gln Phe Ala Gly Ile Asp Asn Pro Ser Glu Leu Val Ser Ala Gln 
            20                  25                  30          


Glu Val Gly Asp Gly Asn Leu Asn Leu Val Phe Lys Val Phe Asp Arg 
        35                  40                  45              


Gln Gly Val Ser Arg Ala Ile Val Lys Gln Ala Leu Pro Tyr Pro Arg 
    50                  55                  60                  


Ala Val Gly Pro Ser Trp Pro Leu Thr Leu Asp Arg Ala Arg His Glu 
65                  70                  75                  80  


Ala Gln Thr Leu Val Ala His Tyr Gln His Ser Pro Gln His Thr Val 
                85                  90                  95      


Lys Ile His His Phe Asp Pro Glu Leu Ala Val Met Val Met Glu Asp 
            100                 105                 110         


Leu Ser Asp His Arg Ile Trp Arg Gly Glu Leu Ile Ala Asn Val Tyr 
        115                 120                 125             


Tyr Pro Gln Ala Ala Arg Gln Leu Gly Asp Tyr Leu Ala Gln Val Leu 
    130                 135                 140                 


Phe His Thr Ser Asp Phe Tyr Leu His Pro His Glu Lys Lys Ala Gln 
145                 150                 155                 160 


Val Ala Gln Phe Ile Asn Pro Gly Met Cys Glu Ile Ser Glu Asp Leu 
                165                 170                 175     


Ser Phe Asn Asp Pro Tyr Gln Ile His Glu Arg Asn Asn Tyr Pro Ala 
            180                 185                 190         


Glu Leu Glu Ala Asp Val Ala Ala Leu Arg Asp Asp Ala Gln Leu Lys 
        195                 200                 205             


Leu Ala Val Ala Ala Leu Lys His Arg Phe Phe Ala His Ala Glu Ala 
    210                 215                 220                 


Leu Leu His Gly Asp Leu His Ser Gly Ser Ile Phe Val Ala Glu Gly 
225                 230                 235                 240 


Ser Leu Lys Val Ile Asp Ala Glu Phe Gly Tyr Phe Gly Pro Ile Gly 
                245                 250                 255     


Phe Asp Ile Gly Thr Ala Ile Gly Asn Leu Leu Leu Asn Tyr Cys Gly 
            260                 265                 270         


Leu Pro Gly Gln Leu Gly Ile Arg Asp Ala Ala Ala Ala Arg Glu Gln 
        275                 280                 285             


Arg Leu Asn Asp Ile His Gln Leu Trp Thr Thr Phe Ala Glu Arg Phe 
    290                 295                 300                 


Gln Ala Leu Ala Ala Glu Lys Thr Arg Asp Ala Ala Leu Ala Tyr Pro 
305                 310                 315                 320 


Gly Tyr Ala Ser Ala Phe Leu Lys Lys Val Trp Ala Asp Ala Val Gly 
                325                 330                 335     


Phe Cys Gly Ser Glu Leu Ile Arg Arg Ser Val Gly Leu Ser His Val 
            340                 345                 350         


Ala Asp Ile Asp Thr Ile Gln Asp Asp Ala Met Arg His Glu Cys Leu 
        355                 360                 365             


Arg His Ala Ile Thr Leu Gly Arg Ala Leu Ile Val Leu Ala Glu Thr 
    370                 375                 380                 


Ile Asp Ser Val Asp Glu Leu Leu Ala Arg Val Arg Gln Tyr Ser Leu 
385                 390                 395                 400 


Glu His His His His His His 
                405         


<210> 10
<211> 1224
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Corresponding DNA seq 8

<400> 10
atgagccagt atcatacctt caccgcggat gatgcggtgg cgtatgcgca gcaatttgcg       60

ggcattgata acccgagcga gctggttagc gcgcaagaag ttggtgacgg caacctgaac      120

ctggtgttca aggtttttga tcgtcagggt gtgagccgtg cgatcgttaa acaagcgctg      180

ccgtaccccc gtgcggttgg tccgagctgg ccgctgaccc tggaccgtgc gcgtcatgaa      240

gcgcagaccc tggtggcgca ctatcagcac agcccgcaac acaccgttaa gatccaccac      300

ttcgatccgg agctggcggt gatggttatg gaagacctga gcgatcaccg tatttggcgt      360

ggtgagctga tcgcgaacgt gtactatccg caggcggcgc gtcaactggg tgactacctg      420

gcgcaggttc tgttccacac cagcgatttt tatctgcacc cgcacgagaa gaaagcgcag      480

gtggcgcaat tcattaaccc gggcatgtgc gaaatcagcg aagacctgag ctttaacgat      540

ccgtaccaga ttcacgaacg taacaactat ccggcggagc tggaagcgga tgtggcggcg      600

ctgcgtgatg atgcgcaact gaagctggcg gttgcggcgc tgaaacaccg tttctttgcg      660

catgcggagg cgctgctgca tggtgacctt cacagcggca gcatcttcgt tgcggagggt      720

agcctgaagg tgatcgacgc ggaattcggt tactttggcc cgatcggttt tgatattggt      780

accgcgatcg gcaacctgct gctgaactat tgcggtctgc cgggtcaact gggtattcgt      840

gatgcggcgg cggcgcgtga acagcgtctg aacgatatcc accaactgtg gaccaccttc      900

gcggagcgtt ttcaagcgct ggcggcggaa aagacccgtg acgcggcgct ggcgtacccg      960

ggttatgcga gcgcgttcct gaagaaagtg tgggcggatg cggttggttt ttgcggcagc     1020

gagctgattc gtcgtagcgt gggcctgtcg cacgttgcgg acatcgatac cattcaggac     1080

gatgcgatgc gtcacgaatg cctgcgtcac gcgatcaccc tgggtcgtgc gctgattgtt     1140

ctggcggaga ccatcgacag cgtggatgaa ctgctggcgc gtgttcgtca atacagcctc     1200

gagcaccacc accaccacca ctga                                            1224


<210> 11
<211> 407
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> MTR kinase (rd5BB)

<400> 11
Met Ser Gln Tyr His Thr Phe Thr Ala Asp Asp Ala Val Ala Tyr Ala 
1               5                   10                  15      


Gln Gln Phe Ala Gly Ile Asp Asn Pro Ser Glu Leu Val Ser Ala Gln 
            20                  25                  30          


Glu Val Gly Asp Gly Asn Leu Asn Leu Val Phe Lys Val Phe Asp Arg 
        35                  40                  45              


Gln Gly Val Ser Arg Ala Ile Val Lys Gln Ala Leu Pro Tyr Pro Arg 
    50                  55                  60                  


Arg Val Gly Pro Ser Trp Pro Leu Thr Leu Asp Arg Ala Arg His Glu 
65                  70                  75                  80  


Ala Gln Thr Leu Val Ala His Tyr Gln His Ser Pro Gln His Thr Val 
                85                  90                  95      


Lys Ile Phe His Phe Asp Pro Glu Leu Ala Val Met Val Met Glu Asp 
            100                 105                 110         


Leu Ser Asp His Arg Ile Trp Arg Gly Glu Leu Ile Ala Asn Val Tyr 
        115                 120                 125             


Tyr Pro Gln Ala Ala Arg Gln Leu Gly Asp Tyr Leu Ala Gln Val Leu 
    130                 135                 140                 


Phe His Thr Ser Asp Phe Tyr Leu His Pro His Glu Lys Lys Arg Gln 
145                 150                 155                 160 


Val Ala Gln Phe Ile Asn Pro Ala Met Cys Gly Ile Ser Glu Asp Leu 
                165                 170                 175     


Val Phe Asn Asp Pro Tyr Gln Ile His Glu Arg Asn Asn Tyr Pro Ala 
            180                 185                 190         


Glu Leu Glu Ala Gln Val Ala Ala Leu Arg Asp Asp Ala Gln Leu Lys 
        195                 200                 205             


Leu Ala Val Ala Ala Leu Lys His Arg Phe Phe Ala His Ala Glu Ala 
    210                 215                 220                 


Leu Leu His Gly Asp Leu His Thr Gly Ser Ile Phe Val Lys Glu Gly 
225                 230                 235                 240 


Ser Leu Lys Val Ile Asp Ala Glu Phe Gly Tyr Phe Gly Pro Ile Gly 
                245                 250                 255     


Phe Asp Ile Gly Thr Ala Ile Gly Asn Leu Leu Leu Asn Tyr Cys Gly 
            260                 265                 270         


Leu Pro Gly Gln Leu Gly Ile Arg Asp Ala Ala Ala Ala Arg Glu Gln 
        275                 280                 285             


Arg Leu Asn Asp Ile His Gln Leu Trp Thr Thr Phe Ala Glu Arg Phe 
    290                 295                 300                 


Gln Ala Leu Ala Ala Glu Lys Thr Arg Asp Ala Ala Leu Ala Tyr Pro 
305                 310                 315                 320 


Gly Tyr Ala Ser Ala Phe Leu Lys Lys Val Trp Ala Asp Ala Val Gly 
                325                 330                 335     


Phe Cys Gly Ser Glu Leu Ile Arg Arg Ser Val Gly Leu Ala His Val 
            340                 345                 350         


Ala Asp Ile Asp Thr Ile Gln Asp Asp Ala Met Arg His Glu Cys Leu 
        355                 360                 365             


Arg Glu Ala Ile Thr Leu Gly Arg Ala Leu Ile Val Leu Ala Glu Arg 
    370                 375                 380                 


Ile Asp Ser Val Asp Glu Leu Leu Ala Arg Val Arg Gln Tyr Ser Leu 
385                 390                 395                 400 


Glu His His His His His His 
                405         


<210> 12
<211> 407
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> MTR kinase (rd6BB)

<400> 12
Met Ser Gln Tyr His Thr Phe Thr Ala Asp Asp Ala Val Ala Tyr Ala 
1               5                   10                  15      


Gln Gln Phe Ala Gly Ile Asp Asn Pro Ser Glu Leu Val Ser Ala Gln 
            20                  25                  30          


Glu Val Gly Asp Gly Asn Leu Asn Leu Val Phe Lys Val Phe Asp Arg 
        35                  40                  45              


Gln Gly Val Ser Arg Ser Ile Val Lys Gln Ala Leu Pro Tyr Pro Arg 
    50                  55                  60                  


Arg Val Gly Pro Ser Trp Pro Leu Thr Leu Asp Arg Ala Arg His Glu 
65                  70                  75                  80  


Ala Gln Thr Leu Val Ala His Tyr Gln His Ser Pro Gln His Thr Val 
                85                  90                  95      


Lys Ile Phe His Phe Asp Pro Glu Leu Ala Val Met Val Met Glu Asp 
            100                 105                 110         


Leu Ser Asp His Arg Ile Trp Arg Gly Glu Leu Ile Ala Asn Val Tyr 
        115                 120                 125             


Tyr Pro Gln Ala Ala Arg Gln Leu Gly Asp Tyr Leu Ala Gln Val Leu 
    130                 135                 140                 


Phe His Thr Ser Asp Phe Tyr Leu His Pro His Glu Lys Lys Arg Gln 
145                 150                 155                 160 


Val Ala Gln Phe Ile Asn Pro Ala Met Cys Gly Ile Ser Glu Asp Leu 
                165                 170                 175     


Val Phe Asn Asp Pro Tyr Gln Ile His Glu Arg Asn Asn Tyr Pro Ala 
            180                 185                 190         


Glu Leu Glu Ala Gln Val Ala Ala Leu Arg Asp Asp Ala Gln Leu Lys 
        195                 200                 205             


Leu Ala Val Ala Ala Leu Lys His Arg Phe Phe Ala His Ala Glu Ala 
    210                 215                 220                 


Leu Leu His Gly Asp Leu His Thr Gly Ser Ile Phe Val Lys Glu Gly 
225                 230                 235                 240 


Ser Leu Lys Val Ile Asp Ala Glu Phe Gly Tyr Phe Gly Pro Ile Gly 
                245                 250                 255     


Phe Asp Ile Gly Thr Ala Ile Gly Asn Leu Leu Leu Asn Tyr Cys Gly 
            260                 265                 270         


Leu Pro Gly Gln Leu Gly Ile Arg Asp Ala Ala Ala Ala Arg Glu Gln 
        275                 280                 285             


Arg Leu Asn Asp Ile His Gln Leu Trp Thr Thr Phe Ala Glu Arg Phe 
    290                 295                 300                 


Gln Ala Leu Ala Ala Glu Lys Thr Arg Asp Ala Ala Leu Arg Tyr Pro 
305                 310                 315                 320 


Gly Tyr Ala Ser Ala Phe Leu Lys Lys Val Trp Ala Asp Ala Val Gly 
                325                 330                 335     


Phe Cys Gly Ser Glu Leu Ile Arg Arg Ser Val Gly Leu Ala His Val 
            340                 345                 350         


Ala Asp Ile Asp Thr Ile Gln Asp Asp Ala Met Arg His Glu Cys Leu 
        355                 360                 365             


Arg Glu Ala Ile Thr Leu Gly Arg Ala Leu Ile Val Leu Ala Glu Arg 
    370                 375                 380                 


Ile Asp Ser Val Asp Glu Leu Leu Ala Arg Val Arg Gln Tyr Ser Leu 
385                 390                 395                 400 


Glu His His His His His His 
                405         


<210> 13
<211> 397
<212> PRT
<213> Bacillus subtilis

<400> 13
Met Gly Val Thr Lys Thr Pro Leu Tyr Glu Thr Leu Asn Glu Ser Ser 
1               5                   10                  15      


Ala Val Ala Leu Ala Val Lys Leu Gly Leu Phe Pro Ser Lys Ser Thr 
            20                  25                  30          


Leu Thr Cys Gln Glu Ile Gly Asp Gly Asn Leu Asn Tyr Val Phe His 
        35                  40                  45              


Ile Tyr Asp Gln Glu His Asp Arg Ala Leu Ile Ile Lys Gln Ala Val 
    50                  55                  60                  


Pro Tyr Ala Lys Val Val Gly Glu Ser Trp Pro Leu Thr Ile Asp Arg 
65                  70                  75                  80  


Ala Arg Ile Glu Ser Ser Ala Leu Ile Arg Gln Gly Glu His Val Pro 
                85                  90                  95      


His Leu Val Pro Arg Val Phe Tyr Ser Asp Thr Glu Met Ala Val Thr 
            100                 105                 110         


Val Met Glu Asp Leu Ser His Leu Lys Ile Ala Arg Lys Gly Leu Ile 
        115                 120                 125             


Glu Gly Glu Asn Tyr Pro His Leu Ser Gln His Ile Gly Glu Phe Leu 
    130                 135                 140                 


Gly Lys Thr Leu Phe Tyr Ser Ser Asp Tyr Ala Leu Glu Pro Lys Val 
145                 150                 155                 160 


Lys Lys Gln Leu Val Lys Gln Phe Thr Asn Pro Glu Leu Cys Asp Ile 
                165                 170                 175     


Thr Glu Arg Leu Val Phe Thr Asp Pro Phe Phe Asp His Asp Thr Asn 
            180                 185                 190         


Asp Phe Glu Glu Glu Leu Arg Pro Phe Val Glu Lys Leu Trp Asn Asn 
        195                 200                 205             


Asp Ser Val Lys Ile Glu Ala Ala Lys Leu Lys Lys Ser Phe Leu Thr 
    210                 215                 220                 


Ser Ala Glu Thr Leu Ile His Gly Asp Leu His Thr Gly Ser Ile Phe 
225                 230                 235                 240 


Ala Ser Glu His Glu Thr Lys Val Ile Asp Pro Glu Phe Ala Phe Tyr 
                245                 250                 255     


Gly Pro Ile Gly Phe Asp Val Gly Gln Phe Ile Ala Asn Leu Phe Leu 
            260                 265                 270         


Asn Ala Leu Ser Arg Asp Gly Ala Asp Arg Glu Pro Leu Tyr Glu His 
        275                 280                 285             


Val Asn Gln Val Trp Glu Thr Phe Glu Glu Thr Phe Ser Glu Ala Trp 
    290                 295                 300                 


Gln Lys Asp Ser Leu Asp Val Tyr Ala Asn Ile Asp Gly Tyr Leu Thr 
305                 310                 315                 320 


Asp Thr Leu Ser His Ile Phe Glu Glu Ala Ile Gly Phe Ala Gly Cys 
                325                 330                 335     


Glu Leu Ile Arg Arg Thr Ile Gly Leu Ala His Val Ala Asp Leu Asp 
            340                 345                 350         


Thr Ile Val Pro Phe Asp Lys Arg Ile Gly Arg Lys Arg Leu Ala Leu 
        355                 360                 365             


Glu Thr Gly Thr Ala Phe Ile Glu Lys Arg Ser Glu Phe Lys Thr Ile 
    370                 375                 380                 


Thr Asp Val Ile Glu Leu Phe Lys Leu Leu Val Lys Glu 
385                 390                 395         


<210> 14
<211> 403
<212> PRT
<213> Thermotoga maritima

<400> 14
Met Arg Val Leu Val Ile Asn Ser Gly Ser Ser Ser Ile Lys Tyr Gln 
1               5                   10                  15      


Leu Ile Glu Met Glu Gly Glu Lys Val Leu Cys Lys Gly Ile Ala Glu 
            20                  25                  30          


Arg Ile Gly Ile Glu Gly Ser Arg Leu Val His Arg Val Gly Asp Glu 
        35                  40                  45              


Lys His Val Ile Glu Arg Glu Leu Pro Asp His Glu Glu Ala Leu Lys 
    50                  55                  60                  


Leu Ile Leu Asn Thr Leu Val Asp Glu Lys Leu Gly Val Ile Lys Asp 
65                  70                  75                  80  


Leu Lys Glu Ile Asp Ala Val Gly His Arg Val Val His Gly Gly Glu 
                85                  90                  95      


Arg Phe Lys Glu Ser Val Leu Val Asp Glu Glu Val Leu Lys Ala Ile 
            100                 105                 110         


Glu Glu Val Ser Pro Leu Ala Pro Leu His Asn Pro Ala Asn Leu Met 
        115                 120                 125             


Gly Ile Lys Ala Ala Met Lys Leu Leu Pro Gly Val Pro Asn Val Ala 
    130                 135                 140                 


Val Phe Asp Thr Ala Phe His Gln Thr Ile Pro Gln Lys Ala Tyr Leu 
145                 150                 155                 160 


Tyr Ala Ile Pro Tyr Glu Tyr Tyr Glu Lys Tyr Lys Ile Arg Arg Tyr 
                165                 170                 175     


Gly Phe His Gly Thr Ser His Arg Tyr Val Ser Lys Arg Ala Ala Glu 
            180                 185                 190         


Ile Leu Gly Lys Lys Leu Glu Glu Leu Lys Ile Ile Thr Cys His Ile 
        195                 200                 205             


Gly Asn Gly Ala Ser Val Ala Ala Val Lys Tyr Gly Lys Cys Val Asp 
    210                 215                 220                 


Thr Ser Met Gly Phe Thr Pro Leu Glu Gly Leu Val Met Gly Thr Arg 
225                 230                 235                 240 


Ser Gly Asp Leu Asp Pro Ala Ile Pro Phe Phe Ile Met Glu Lys Glu 
                245                 250                 255     


Gly Ile Ser Pro Gln Glu Met Tyr Asp Ile Leu Asn Lys Lys Ser Gly 
            260                 265                 270         


Val Tyr Gly Leu Ser Lys Gly Phe Ser Ser Asp Met Arg Asp Ile Glu 
        275                 280                 285             


Glu Ala Ala Leu Lys Gly Asp Glu Trp Cys Lys Leu Val Leu Glu Ile 
    290                 295                 300                 


Tyr Asp Tyr Arg Ile Ala Lys Tyr Ile Gly Ala Tyr Ala Ala Ala Met 
305                 310                 315                 320 


Asn Gly Val Asp Ala Ile Val Phe Thr Ala Gly Val Gly Glu Asn Ser 
                325                 330                 335     


Pro Ile Thr Arg Glu Asp Val Cys Ser Tyr Leu Glu Phe Leu Gly Val 
            340                 345                 350         


Lys Leu Asp Lys Gln Lys Asn Glu Glu Thr Ile Arg Gly Lys Glu Gly 
        355                 360                 365             


Ile Ile Ser Thr Pro Asp Ser Arg Val Lys Val Leu Val Val Pro Thr 
    370                 375                 380                 


Asn Glu Glu Leu Met Ile Ala Arg Asp Thr Lys Glu Ile Val Glu Lys 
385                 390                 395                 400 


Ile Gly Arg 
            


<210> 15
<211> 1212
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Corresponding DNA seq  14

<400> 15
atgcgtgttc tggttattaa tagcggtagc agcagcatta aatatcagct gattgaaatg       60

gaaggtgaaa aagttctgtg taaaggtatt gcagaacgta ttggtattga aggtagccgt      120

ctggttcatc gtgttggtga tgaaaaacat gttattgaac gtgaactgcc ggatcatgaa      180

gaagcactga aactgattct gaataccctg gttgatgaaa aactgggtgt tattaaagat      240

ctgaaagaaa ttgacgcagt tggtcatcgt gttgttcatg gtggtgaacg ttttaaagaa      300

agcgttctgg ttgatgaaga agttctgaaa gcaattgaag aagttagccc gctggcaccg      360

ctgcataatc cggcaaatct gatgggtatt aaagcagcaa tgaaactgct gccgggtgtt      420

ccgaatgttg cagtttttga taccgcattt catcagacca ttccgcagaa agcatatctg      480

tatgcaattc cgtatgaata ttacgaaaaa tacaaaattc gtcgctacgg ttttcatggt      540

accagccatc gttatgttag caaacgtgca gcagaaattc tgggtaaaaa actggaagaa      600

ctgaaaatta tcacctgtca tattggtaat ggtgcaagcg ttgcagcagt taaatatggt      660

aaatgtgttg ataccagcat gggttttacc ccgctggaag gtctggttat gggtacccgt      720

agcggtgatc tggatccggc aattccgttt tttattatgg aaaaagaggg tattagcccg      780

caggaaatgt atgatattct gaataaaaaa agcggcgttt atggtctgag caaaggtttt      840

agcagcgata tgcgtgatat tgaagaagca gcactgaaag gtgatgaatg gtgtaaactg      900

gttctggaaa tttatgatta ccgtattgca aaatacatcg gtgcatacgc tgcagcaatg      960

aatggtgttg atgcaattgt ttttaccgca ggtgttggtg aaaatagccc gattacccgt     1020

gaagatgttt gtagctatct ggaatttctg ggtgttaaac tggataaaca gaaaaatgaa     1080

gagaccattc gtggtaaaga aggtattatt agcaccccgg atagccgtgt taaagttctg     1140

gttgttccga ccaatgaaga actgatgatt gcacgtgata ccaaagaaat tgttgaaaaa     1200

atcggtcgtt aa                                                         1212


<210> 16
<211> 413
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> acetate kinase AcK-101

<400> 16
Met Gly Ser His His His His His His Gly Ser Arg Val Leu Asn Ile 
1               5                   10                  15      


Asn Ser Gly Ser Ser Ser Ile Lys Tyr Gln Leu Ile Glu Met Glu Gly 
            20                  25                  30          


Glu Lys Val Leu Cys Lys Gly Ile Ala Glu Arg Ile Gly Ile Glu Gly 
        35                  40                  45              


Ser Arg Leu Val His Arg Val Gly Asp Glu Lys His Val Ile Glu Arg 
    50                  55                  60                  


Glu Leu Pro Asp His Glu Glu Ala Leu Lys Leu Ile Leu Asn Thr Leu 
65                  70                  75                  80  


Val Asp Glu Lys Leu Gly Val Ile Lys Asp Leu Lys Glu Ile Asp Ala 
                85                  90                  95      


Val Gly His Arg Val Val His Gly Gly Glu Arg Phe Lys Glu Ser Val 
            100                 105                 110         


Leu Val Asp Glu Glu Val Leu Lys Ala Ile Glu Glu Val Ser Pro Leu 
        115                 120                 125             


Ala Pro Leu His Asn Pro Ala Asn Leu Met Gly Ile Lys Ala Ala Met 
    130                 135                 140                 


Lys Leu Leu Pro Gly Val Pro Asn Val Gln Val Phe Asp Thr Ala Phe 
145                 150                 155                 160 


His Gln Thr Ile Pro Gln Lys Ala Tyr Leu Tyr Ala Ile Pro Tyr Glu 
                165                 170                 175     


Tyr Tyr Glu Lys Tyr Lys Ile Arg Arg Tyr Gly Phe His Gly Ile Ser 
            180                 185                 190         


His Arg Tyr Val Ser Lys Arg Ala Ala Glu Ile Leu Gly Lys Lys Leu 
        195                 200                 205             


Glu Glu Leu Lys Ile Ile Thr Cys His Ile Gly Asn Gly Ala Ser Val 
    210                 215                 220                 


Ala Ala Val Lys Tyr Gly Lys Cys Val Asp Thr Ser Met Gly Phe Thr 
225                 230                 235                 240 


Pro Leu Glu Gly Leu Val Met Gly Thr Arg Ser Gly Asp Leu Asp Pro 
                245                 250                 255     


Ala Ile Pro Phe Phe Ile Met Glu Lys Glu Gly Ile Ser Pro Gln Glu 
            260                 265                 270         


Met Tyr Asp Ile Leu Asn Lys Lys Ser Gly Val Tyr Gly Leu Ser Lys 
        275                 280                 285             


Gly Phe Ser Ser Asp Met Arg Asp Asn Phe Glu Ala Ala Leu Lys Gly 
    290                 295                 300                 


Asp Glu Trp Cys Lys Leu Val Leu Glu Ile Tyr Asp Tyr Arg Ile Ala 
305                 310                 315                 320 


Lys Tyr Ile Gly Ala Tyr Ala Ala Ala Met Asn Gly Val Asp Ala Ile 
                325                 330                 335     


Val Phe Thr Ala Gly Val Gly Glu Asn Ser Pro Ile Thr Arg Glu Asp 
            340                 345                 350         


Val Cys Lys Tyr Leu Glu Phe Leu Gly Val Lys Leu Asp Lys Gln Lys 
        355                 360                 365             


Asn Glu Glu Thr Ile Leu Gly Lys Glu Gly Ile Ile Ser Thr Pro Asp 
    370                 375                 380                 


Ser Arg Val Lys Val Leu Val Val Pro Thr Asn Glu Glu Leu Met Ile 
385                 390                 395                 400 


Ala Arg Asp Thr Lys Glu Ile Val Glu Lys Ile Gly Arg 
                405                 410             


<210> 17
<211> 1242
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Corresponding DNA seq  16

<400> 17
atgggtagcc atcatcatca tcatcacggt agccgtgttc tgaatatcaa tagcggtagc       60

agcagcatta aatatcagct gattgaaatg gaaggtgaaa aagttctgtg taaaggtatt      120

gcagaacgta ttggtattga aggtagccgt ctggttcatc gtgttggtga tgaaaaacat      180

gttattgaac gtgaactgcc ggatcatgaa gaagcactga aactgattct gaataccctg      240

gttgatgaaa aactgggtgt tattaaagat ctgaaagaaa ttgacgcagt tggtcatcgt      300

gttgttcatg gtggtgaacg ttttaaagaa agcgttctgg ttgatgaaga agttctgaaa      360

gcaattgaag aagttagccc gctggcaccg ctgcataatc cggcaaatct gatgggtatt      420

aaagcagcaa tgaaactgct gccgggtgtt ccgaatgttc aagtttttga taccgcattt      480

catcagacca ttccgcagaa agcatatctg tatgcaattc cgtatgaata ttacgaaaaa      540

tacaaaattc gtcgctacgg ttttcatggt atcagccatc gttatgttag caaacgtgca      600

gcagaaattc tgggtaaaaa actggaagaa ctgaaaatta tcacctgtca tattggtaat      660

ggtgcaagcg ttgcagcagt taaatatggt aaatgtgttg ataccagcat gggttttacc      720

ccgctggaag gtctggttat gggtacccgt agcggtgatc tggatccggc aattccgttt      780

tttattatgg aaaaagaggg tattagcccg caggaaatgt atgatattct gaataaaaaa      840

agcggcgttt atggtctgag caaaggtttt agcagcgata tgcgtgataa ttttgaagca      900

gcactgaaag gtgatgaatg gtgtaaactg gttctggaaa tttatgacta ccgtattgca      960

aaatacatcg gtgcatacgc tgcagcaatg aatggtgttg atgcaattgt ttttaccgca     1020

ggtgttggtg aaaatagccc gatcacccgt gaagatgttt gtaagtatct ggaatttctg     1080

ggtgttaaac tggataaaca gaaaaatgaa gagactattc tgggtaaaga aggtattatt     1140

agcaccccgg atagccgtgt taaagttctg gttgttccga ccaatgaaga actgatgatt     1200

gcacgtgata ccaaagaaat tgttgaaaaa atcggtcgtt aa                        1242


<210> 18
<211> 592
<212> PRT
<213> Aerococcus viridans

<400> 18
Met Ser Asp Asn Lys Ile Asn Ile Gly Leu Ala Val Met Lys Ile Leu 
1               5                   10                  15      


Glu Ser Trp Gly Ala Asp Thr Ile Tyr Gly Ile Pro Ser Gly Thr Leu 
            20                  25                  30          


Ser Ser Leu Met Asp Ala Met Gly Glu Glu Glu Asn Asn Val Lys Phe 
        35                  40                  45              


Leu Gln Val Lys His Glu Glu Val Gly Ala Met Ala Ala Val Met Gln 
    50                  55                  60                  


Ser Lys Phe Gly Gly Asn Leu Gly Val Thr Val Gly Ser Gly Gly Pro 
65                  70                  75                  80  


Gly Ala Ser His Leu Ile Asn Gly Leu Tyr Asp Ala Ala Met Asp Asn 
                85                  90                  95      


Ile Pro Val Val Ala Ile Leu Gly Ser Arg Pro Gln Arg Glu Leu Asn 
            100                 105                 110         


Met Asp Ala Phe Gln Glu Leu Asn Gln Asn Pro Met Tyr Asp His Ile 
        115                 120                 125             


Ala Val Tyr Asn Arg Arg Val Ala Tyr Ala Glu Gln Leu Pro Lys Leu 
    130                 135                 140                 


Val Asp Glu Ala Ala Arg Met Ala Ile Ala Lys Arg Gly Val Ala Val 
145                 150                 155                 160 


Leu Glu Val Pro Gly Asp Phe Ala Lys Val Glu Ile Asp Asn Asp Gln 
                165                 170                 175     


Trp Tyr Ser Ser Ala Asn Ser Leu Arg Lys Tyr Glu Pro Ile Ala Pro 
            180                 185                 190         


Ala Ala Gln Asp Ile Asp Ala Ala Val Glu Leu Leu Asn Asn Ser Lys 
        195                 200                 205             


Arg Pro Val Ile Tyr Ala Gly Ile Gly Thr Met Gly His Gly Pro Ala 
    210                 215                 220                 


Val Gln Glu Leu Ala Arg Lys Ile Lys Ala Pro Val Ile Thr Thr Gly 
225                 230                 235                 240 


Lys Asn Phe Glu Thr Phe Glu Trp Asp Phe Glu Ala Leu Thr Gly Ser 
                245                 250                 255     


Thr Tyr Arg Val Gly Trp Lys Pro Ala Asn Glu Thr Ile Leu Glu Ala 
            260                 265                 270         


Asp Thr Val Leu Phe Ala Gly Ser Asn Phe Pro Phe Ser Glu Val Glu 
        275                 280                 285             


Gly Thr Phe Arg Asn Val Asp Asn Phe Ile Gln Ile Asp Ile Asp Pro 
    290                 295                 300                 


Ala Met Leu Gly Lys Arg His His Ala Asp Val Ala Ile Leu Gly Asp 
305                 310                 315                 320 


Ala Gly Leu Ala Ile Asp Glu Ile Leu Asn Lys Val Asp Ala Val Glu 
                325                 330                 335     


Glu Ser Ala Trp Trp Thr Ala Asn Leu Lys Asn Ile Ala Asn Trp Arg 
            340                 345                 350         


Glu Tyr Ile Asn Met Leu Glu Thr Lys Glu Glu Gly Asp Leu Gln Phe 
        355                 360                 365             


Tyr Gln Val Tyr Asn Ala Ile Asn Asn His Ala Asp Glu Asp Ala Ile 
    370                 375                 380                 


Tyr Ser Ile Asp Val Gly Asn Ser Thr Gln Thr Ser Ile Arg His Leu 
385                 390                 395                 400 


His Met Thr Pro Lys Asn Met Trp Arg Thr Ser Pro Leu Phe Ala Thr 
                405                 410                 415     


Met Gly Ile Ala Ile Pro Gly Gly Leu Gly Ala Lys Asn Thr Tyr Pro 
            420                 425                 430         


Asp Arg Gln Val Trp Asn Ile Ile Gly Asp Gly Ala Phe Ser Met Thr 
        435                 440                 445             


Tyr Pro Asp Val Val Thr Asn Val Arg Tyr Asn Met Pro Val Ile Asn 
    450                 455                 460                 


Val Val Phe Ser Asn Thr Glu Tyr Ala Phe Ile Lys Asn Lys Tyr Glu 
465                 470                 475                 480 


Asp Thr Asn Lys Asn Leu Phe Gly Val Asp Phe Thr Asp Val Asp Tyr 
                485                 490                 495     


Ala Lys Ile Ala Glu Ala Gln Gly Ala Lys Gly Phe Thr Val Ser Arg 
            500                 505                 510         


Ile Glu Asp Met Asp Arg Val Met Ala Glu Ala Val Ala Ala Asn Lys 
        515                 520                 525             


Ala Gly His Thr Val Val Ile Asp Cys Lys Ile Thr Gln Asp Arg Pro 
    530                 535                 540                 


Ile Pro Val Glu Thr Leu Lys Leu Asp Ser Lys Leu Tyr Ser Glu Asp 
545                 550                 555                 560 


Glu Ile Lys Ala Tyr Lys Glu Arg Tyr Glu Ala Ala Asn Leu Val Pro 
                565                 570                 575     


Phe Arg Glu Tyr Leu Glu Ala Glu Gly Leu Glu Ser Lys Tyr Ile Lys 
            580                 585                 590         


<210> 19
<211> 1779
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Corresponding DNA seq 18

<400> 19
atgagtgata ataaaatcaa catcggtctg gcggtgatga aaattctgga aagttggggc       60

gcagatacca tttatggcat tccgagcggc accctgagta gcttaatgga tgccatgggt      120

gaagaagaaa acaatgttaa gttcctgcag gtgaagcatg aagaagtggg cgcaatggca      180

gccgttatgc agagtaaatt tggcggtaat ctgggtgtga ccgttggtag tggcggtcct      240

ggtgcaagtc atctgattaa tggcctgtat gatgccgcaa tggataatat tccggttgtg      300

gcaattctgg gtagccgtcc tcagcgtgaa ctgaatatgg atgcatttca ggaactgaac      360

cagaatccga tgtatgatca tatcgccgtt tacaatcgcc gtgtggccta tgcagaacag      420

ctgcctaaac tggtggatga agccgcccgt atggccattg ctaaacgcgg tgtggcagtt      480

ctggaagttc cgggtgattt tgcaaaagtg gaaattgata acgaccagtg gtacagtagc      540

gcaaatagcc tgcgcaaata tgaaccgatt gccccggcag cacaggatat tgatgcagct      600

gtggaactgc tgaataatag taaacgcccg gtgatttacg caggtattgg taccatgggc      660

catggccctg cagttcaaga actggctcgt aaaattaagg caccggtgat taccaccggt      720

aaaaattttg aaaccttcga gtgggacttc gaagccctga ccggttcaac ctatcgtgtg      780

ggttggaaac cggcaaatga aaccattctg gaagccgata ccgttctgtt tgcaggcagc      840

aattttccgt ttagcgaagt ggaaggcacc tttcgtaatg ttgataattt catccagatc      900

gacatcgacc cggcaatgct gggtaaacgc catcatgcag atgtggcaat tctgggtgat      960

gccggcctgg caattgatga aattctgaat aaggtggacg ccgtggaaga aagcgcctgg     1020

tggaccgcaa atctgaaaaa tattgcaaac tggcgcgagt atatcaacat gctggaaacc     1080

aaagaggagg gtgatctgca gttttatcag gtttataacg cgatcaacaa ccacgccgat     1140

gaagatgcaa tttatagcat tgacgtgggc aatagcaccc agaccagcat tcgtcatctg     1200

cacatgaccc cgaaaaatat gtggcgcacc agcccgctgt ttgccaccat gggtattgca     1260

attccgggtg gcctgggtgc aaaaaatacc tatccggatc gtcaggtgtg gaatattatt     1320

ggcgatggcg cctttagtat gacctatccg gatgttgtta ccaatgttcg ctataatatg     1380

ccggttatca acgtggtttt cagtaatacc gagtacgcat ttatcaagaa caagtacgag     1440

gacaccaaca aaaacctgtt tggtgtggat ttcaccgatg tggattatgc caaaatcgcc     1500

gaagcacagg gtgcaaaagg ctttaccgtg agtcgcattg aagatatgga tcgtgttatg     1560

gccgaagccg tggccgcaaa taaagccggt cataccgttg tgattgattg taaaatcacc     1620

caggaccgtc cgattccggt tgaaaccctg aaactggata gcaaactgta tagtgaggac     1680

gaaatcaagg catataagga acgttacgag gcagcaaatc tggtgccgtt tcgtgaatat     1740

ctggaagccg aaggtctgga aagcaaatat attaagtaa                            1779


<210> 20
<211> 591
<212> PRT
<213> Streptococcus sanguinis

<400> 20
Met Thr Gln Gly Lys Ile Thr Ala Ser Ala Ala Met Leu Asn Val Leu 
1               5                   10                  15      


Lys Thr Trp Gly Val Asp Thr Ile Tyr Gly Ile Pro Ser Gly Thr Leu 
            20                  25                  30          


Ser Ser Leu Met Asp Ala Leu Ala Glu Asp Lys Asp Ile Arg Phe Leu 
        35                  40                  45              


Gln Val Arg His Glu Glu Thr Gly Ala Leu Ala Ala Val Met Gln Ala 
    50                  55                  60                  


Lys Phe Gly Gly Ser Ile Gly Val Ala Val Gly Ser Gly Gly Pro Gly 
65                  70                  75                  80  


Ala Thr His Leu Ile Asn Gly Val Tyr Asp Ala Ala Met Asp Asn Thr 
                85                  90                  95      


Pro Phe Leu Ala Ile Leu Gly Ser Arg Pro Val Asn Glu Leu Asn Met 
            100                 105                 110         


Asp Ala Phe Gln Glu Leu Asn Gln Asn Pro Met Tyr His Gly Ile Ala 
        115                 120                 125             


Val Tyr Asn Lys Arg Val Ala Tyr Ala Glu Gln Leu Pro Lys Val Ile 
    130                 135                 140                 


Asp Glu Ala Cys Arg Ala Ala Val Ser Lys Lys Gly Pro Ala Val Val 
145                 150                 155                 160 


Glu Ile Pro Val Asn Phe Gly Phe Gln Glu Ile Asp Glu Asn Ser Tyr 
                165                 170                 175     


Tyr Gly Ser Gly Ser Tyr Glu Arg Ser Phe Ile Ala Pro Ala Leu Asn 
            180                 185                 190         


Glu Val Glu Ile Asp Lys Ala Val Glu Ile Leu Asn Lys Ala Glu Arg 
        195                 200                 205             


Pro Val Ile Tyr Ala Gly Phe Gly Gly Val Lys Ala Gly Glu Val Ile 
    210                 215                 220                 


Thr Glu Leu Ser Arg Lys Ile Lys Ala Pro Ile Ile Thr Thr Gly Lys 
225                 230                 235                 240 


Asn Phe Glu Ala Phe Glu Trp Asn Tyr Glu Gly Leu Thr Gly Ser Ala 
                245                 250                 255     


Tyr Arg Val Gly Trp Lys Pro Ala Asn Glu Val Val Phe Glu Ala Asp 
            260                 265                 270         


Thr Val Leu Phe Leu Gly Ser Asn Phe Pro Phe Ala Glu Val Tyr Glu 
        275                 280                 285             


Ala Phe Lys Asn Thr Glu Lys Phe Ile Gln Val Asp Ile Asp Pro Tyr 
    290                 295                 300                 


Lys Leu Gly Lys Arg His Ala Leu Asp Ala Ser Ile Leu Gly Asp Ala 
305                 310                 315                 320 


Gly Gln Ala Ala Lys Ala Ile Leu Asp Lys Val Asp Ala Val Glu Ser 
                325                 330                 335     


Thr Pro Trp Trp Arg Ala Asn Val Lys Asn Asn Gln Asn Trp Arg Asp 
            340                 345                 350         


Tyr Met Asn Lys Leu Glu Gly Lys Thr Glu Gly Glu Leu Gln Leu Tyr 
        355                 360                 365             


Gln Val Tyr Asn Ala Ile Asn Lys His Ala Asp Gln Asp Ala Ile Tyr 
    370                 375                 380                 


Ser Ile Asp Val Gly Asn Ser Thr Gln Thr Ser Thr Arg His Leu His 
385                 390                 395                 400 


Met Thr Pro Lys Asn Met Trp Arg Thr Ser Pro Leu Phe Ala Thr Met 
                405                 410                 415     


Gly Ile Ala Leu Pro Gly Gly Ile Ala Ala Lys Lys Asp Asn Pro Glu 
            420                 425                 430         


Arg Gln Val Trp Asn Ile Met Gly Asp Gly Ala Phe Asn Met Cys Tyr 
        435                 440                 445             


Pro Asp Val Ile Thr Asn Val Gln Tyr Asn Leu Pro Val Ile Asn Val 
    450                 455                 460                 


Val Phe Ser Asn Ala Glu Tyr Ala Phe Ile Lys Asn Lys Tyr Glu Asp 
465                 470                 475                 480 


Thr Asn Lys His Leu Phe Gly Val Asp Phe Thr Asn Ala Asp Tyr Ala 
                485                 490                 495     


Lys Ile Ala Glu Ala Gln Gly Ala Val Gly Phe Thr Val Asp Arg Ile 
            500                 505                 510         


Glu Asp Ile Asp Ala Val Val Ala Glu Ala Val Lys Leu Asn Lys Glu 
        515                 520                 525             


Gly Lys Thr Val Val Ile Asp Ala Arg Ile Thr Gln His Arg Pro Leu 
    530                 535                 540                 


Pro Val Glu Val Leu Glu Leu Asp Pro Lys Leu His Ser Glu Glu Ala 
545                 550                 555                 560 


Ile Lys Ala Phe Lys Glu Lys Tyr Glu Ala Glu Glu Leu Val Pro Phe 
                565                 570                 575     


Arg Leu Phe Leu Glu Glu Glu Gly Leu Gln Ser Arg Ala Ile Lys 
            580                 585                 590     


<210> 21
<211> 1776
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Corresponding DNA seq  20

<400> 21
atgacccagg gtaaaattac cgcaagtgcc gcaatgctga atgtgctgaa aacctggggc       60

gttgatacca tttatggtat tccgagtggt accctgagca gcctgatgga tgccttagca      120

gaagataaag atatccgctt tctgcaggtg cgccatgaag aaaccggcgc attagccgca      180

gtgatgcagg caaaatttgg tggcagcatt ggtgttgcag tgggtagcgg tggtccgggt      240

gcaacccacc tgatcaatgg tgtttatgat gccgccatgg ataatacccc gtttctggcc      300

attctgggta gtcgccctgt gaatgaactg aatatggatg cattccagga gctgaatcag      360

aatccgatgt atcatggtat cgccgtttat aataagcgcg ttgcatacgc tgaacagctg      420

ccgaaagtga ttgatgaagc atgccgtgca gccgtgagca aaaaaggccc tgcagtggtt      480

gaaattccgg ttaattttgg cttccaggaa atcgatgaga acagttatta cggcagcggt      540

agttatgaac gtagctttat tgccccggcc ctgaatgaag tggaaattga taaagcagtg      600

gagatcctga acaaggcaga acgcccggtg atttatgcag gctttggtgg cgtgaaagca      660

ggtgaagtga ttaccgaact gagccgcaaa attaaagccc cgattattac caccggcaaa      720

aattttgagg cctttgaatg gaactacgag ggactgaccg gcagtgcata tcgtgtgggt      780

tggaaaccgg caaatgaagt ggtgtttgaa gccgataccg tgctgtttct gggtagcaat      840

tttccgtttg ccgaagttta tgaggcattt aaaaacaccg agaagttcat ccaggtggat      900

attgatccgt ataagctggg caaacgtcat gcactggatg caagtattct gggtgatgca      960

ggtcaggccg caaaagcaat tctggataaa gttgatgccg tggaaagcac cccgtggtgg     1020

cgtgcaaatg tgaaaaataa tcagaactgg cgcgactata tgaacaaact ggaaggcaaa     1080

accgagggtg aactgcagct gtatcaggtt tataatgcca ttaacaagca cgcagaccag     1140

gatgcaattt atagtattga cgtgggcaac agcacccaga ccagtacacg tcatctgcac     1200

atgaccccga aaaatatgtg gcgtaccagc ccgctgtttg caaccatggg tattgccctg     1260

ccgggcggta ttgctgcaaa aaaagataat ccggagcgtc aggtttggaa tattatgggt     1320

gatggtgcct ttaacatgtg ctatccggat gtgattacca atgttcagta caatctgccg     1380

gttattaacg ttgttttcag caatgccgag tacgcattta ttaagaacaa gtacgaggac     1440

accaacaagc atctgtttgg tgttgatttc accaacgccg attatgccaa aattgccgaa     1500

gcacagggcg cagttggttt taccgtggat cgcattgaag atattgacgc agtggttgcc     1560

gaagcagtga aactgaataa agaaggtaag accgtggtga ttgacgcccg cattacccag     1620

catcgccctt tacctgtgga agtgctggaa ctggatccga aactgcatag tgaagaagca     1680

attaaggcct ttaaggagaa gtacgaagcc gaagaactgg tgccgtttcg tctgtttctg     1740

gaagaagaag gcctgcagag tcgcgcaatt aaataa                               1776


<210> 22
<211> 606
<212> PRT
<213> Weissella confusa

<400> 22
Met Ser Asp Lys Lys Ile Ser Ala Gly Leu Ala Ala Leu Lys Val Met 
1               5                   10                  15      


Glu Gly Trp Gly Ile Asp Thr Met Tyr Gly Ile Pro Ser Gly Thr Leu 
            20                  25                  30          


Ser Gly Leu Met Asn Ala Met Gly His Pro Glu Asn Lys Val Lys Phe 
        35                  40                  45              


Ile Gln Val Lys His Glu Glu Ile Gly Ala Met Ala Ala Val Met Gln 
    50                  55                  60                  


Tyr Lys Phe Gly Gly Asn Ile Ala Val Thr Val Gly Ser Gly Gly Pro 
65                  70                  75                  80  


Gly Ala Thr His Leu Ile Asn Gly Leu Tyr Asp Ala Tyr Met Asp His 
                85                  90                  95      


Ile Pro Val Leu Ala Ile Leu Gly Ser Lys Pro Val Arg Glu Leu Asn 
            100                 105                 110         


Met Asp Ser Phe Gln Glu Leu Asn Gln Asn Pro Met Tyr Asp His Ile 
        115                 120                 125             


Ala Val Tyr Asn Arg Arg Val Ala Thr Ala Glu Gln Leu Pro His Leu 
    130                 135                 140                 


Val Asp Asp Ala Ile Arg Thr Ala Ile Ser Lys Arg Gly Val Ala Val 
145                 150                 155                 160 


Leu Glu Val Pro Ala Asp Phe Gly Phe Ala Glu Leu Asp Ala Glu Ser 
                165                 170                 175     


Ile Tyr Ser Thr Pro Leu Tyr Ser Ser Gly Thr Lys Tyr Lys Arg Tyr 
            180                 185                 190         


Lys Pro Val Ala Pro Glu Ala Glu Glu Ile Asp Glu Ala Val Glu Ile 
        195                 200                 205             


Leu Lys Ala Ser Glu Arg Pro Val Ile Tyr Ala Gly Phe Gly Thr Gln 
    210                 215                 220                 


Gly His Gly Asp Leu Val Glu Glu Leu Ser Arg Lys Ile Lys Ala Pro 
225                 230                 235                 240 


Val Ile Thr Thr Gly Lys Asn Phe Asp Asn Phe Asn Trp Asp Phe Glu 
                245                 250                 255     


Ala Leu Thr Gly Ser Ala Phe Arg Val Gly Trp Lys Pro Ala Asn Glu 
            260                 265                 270         


Ala Val Leu Glu Ala Asp Thr Val Leu Phe Ile Gly Thr Asn Phe Pro 
        275                 280                 285             


Phe Ser Glu Val Glu Gly Thr Phe Arg Asn Val Lys Lys Phe Ile Gln 
    290                 295                 300                 


Ile Asp Ala Asn Pro Asp Met Leu Gly Lys Arg His Glu Thr Asp Val 
305                 310                 315                 320 


Ala Ile Leu Ala Asp Ala Gly Glu Ser Leu Lys Ala Leu Leu Ala Lys 
                325                 330                 335     


Val Glu Pro Val Ala Asp Thr Pro Trp Trp Gln Ala Asn Ile Lys Asn 
            340                 345                 350         


Val Gln Asn Trp Arg Asp Tyr Met Asn Lys Leu Glu Gln Lys Thr Glu 
        355                 360                 365             


Gly Pro Leu Gln Ala Tyr Gln Val Tyr Asn Ala Ile Asn Lys Leu Ala 
    370                 375                 380                 


Asp Glu Asp Ala Ile Phe Ser Thr Asp Val Gly Asp Val Thr Gln Leu 
385                 390                 395                 400 


Ser Thr Arg His Leu His Met Asn Pro Lys Gln Met Trp Arg Thr Ser 
                405                 410                 415     


Pro Leu Phe Ala Thr Met Gly Ile Ala Leu Pro Gly Gly Ile Gly Ala 
            420                 425                 430         


Lys Asn Ile Tyr Pro Asp Arg Gln Val Trp Asn Ile Ile Gly Asp Gly 
        435                 440                 445             


Ala Phe Ser Met Thr Tyr Pro Asp Val Val Thr Ser Val Arg Tyr Asp 
    450                 455                 460                 


Met Pro Met Ile Asn Val Ile Phe Thr Asn Thr Glu Tyr Gly Phe Ile 
465                 470                 475                 480 


Lys Asn Lys Tyr Glu Asp Thr Asn Glu Tyr Asn Phe Gly Val Asp Phe 
                485                 490                 495     


Thr Asp Val Asp Tyr Ala Lys Val Gly Glu Ala Gln Gly Ala Ile Gly 
            500                 505                 510         


Leu Thr Val Asn Arg Ile Glu Asp Ile Asp Arg Val Met Gln Glu Ala 
        515                 520                 525             


Val Asp Tyr Tyr Lys Gln Gly Arg Val Val Val Val Asp Ala Lys Ile 
    530                 535                 540                 


Thr Lys Asp Arg Pro Ile Pro Val Glu Thr Leu Lys Leu Asp Thr Asn 
545                 550                 555                 560 


Leu Tyr Ser Glu Asp Val Val Lys Ala Tyr Lys Glu Lys Tyr Glu Ala 
                565                 570                 575     


Glu Ala Leu Val Pro Phe Arg Glu Phe Leu Glu Gly Glu Gly Leu Lys 
            580                 585                 590         


Ser Ile Tyr Ile Lys Glu Asp Asn Asp Asn Lys Phe Ser Phe 
        595                 600                 605     


<210> 23
<211> 1821
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Corresponding DNA seq  22

<400> 23
atgagtgata aaaaaatcag cgcgggcctg gcagcactga aagttatgga aggttggggt       60

attgatacca tgtatggtat tccgagcggt accctgagcg gtttaatgaa tgcaatgggc      120

catccggaaa ataaagttaa attcatccag gtgaagcacg aggaaattgg cgcaatggca      180

gccgttatgc agtataaatt tggtggcaat atcgcggtta ccgttggtag cggtggccct      240

ggtgcaaccc acctgatcaa tggtctgtat gatgcctata tggaccatat tccggttctg      300

gcaattctgg gtagtaaacc ggttcgcgaa ctgaatatgg atagttttca ggaactgaac      360

cagaacccga tgtatgatca tattgccgtt tacaaccgcc gcgttgcaac cgcagaacag      420

ttacctcatc tggtggatga tgcaattcgc accgccatta gtaaacgcgg tgtggctgtt      480

ctggaagttc cggcagattt tggttttgcc gaactggatg ccgaaagcat ttatagcacc      540

ccgctgtata gtagtggcac caaatataaa cgctacaagc cggttgcacc ggaagccgag      600

gaaattgatg aagccgtgga aattctgaag gcaagcgaac gtccggttat ttatgccggt      660

tttggtaccc agggccatgg tgatctggtg gaagaactga gtcgcaaaat taaagcaccg      720

gtgattacca ccggtaaaaa ttttgataac ttcaactggg acttcgaggc actgaccggc      780

tcagcatttc gcgttggttg gaaaccggcc aatgaagccg tgctggaagc cgacacagtt      840

ctgtttattg gcaccaattt cccgtttagt gaggtggaag gcacctttcg caatgttaaa      900

aaattcatcc agatcgacgc aaacccggat atgctgggta aacgtcatga aaccgatgtt      960

gccattctgg cagatgccgg tgaaagcctg aaagccctgc tggcaaaagt tgaaccggtg     1020

gcagataccc cgtggtggca ggcaaatatt aaaaatgtgc agaactggcg cgactatatg     1080

aataaactgg aacagaagac cgagggcccg ctgcaggcat accaggtgta caatgcaatt     1140

aataagctgg ccgatgagga tgccattttt agtaccgatg tgggtgatgt tacccagctg     1200

agcacccgtc atctgcacat gaatccgaaa cagatgtggc gtaccagtcc gctgtttgca     1260

accatgggca ttgccctgcc gggtggtatt ggagcaaaaa atatttaccc ggaccgtcag     1320

gtttggaata ttattggcga tggcgcattt agcatgacct atccggatgt tgttaccagt     1380

gttcgttatg atatgccgat gattaacgtg atcttcacca ataccgagta cggttttatc     1440

aagaacaagt acgaggacac caacgaatat aacttcggcg tggattttac cgatgtggat     1500

tatgccaaag tgggcgaagc ccagggcgca atcggtctga ccgtgaacag aattgaagat     1560

attgaccgcg tgatgcagga agccgtggat tattataaac agggtcgcgt tgttgtggtt     1620

gatgcaaaaa ttaccaagga ccgcccgatt ccggttgaaa ccctgaaact ggataccaat     1680

ctgtatagtg aggacgttgt taaggcctat aaggaaaaat acgaggcaga agcactggtt     1740

ccgtttcgcg aatttctgga aggtgaaggt ctgaaaagta tctatatcaa ggaggacaac     1800

gacaacaagt tcagttttta a                                               1821


<210> 24
<211> 593
<212> PRT
<213> Streptococcus thermophilus

<400> 24
Met Thr Val Gly Lys Thr Lys Val Ser Thr Ala Ser Leu Lys Val Leu 
1               5                   10                  15      


Ala Gly Trp Gly Ile Asp Thr Ile Tyr Gly Ile Pro Ser Gly Thr Leu 
            20                  25                  30          


Ala Pro Leu Met Glu Ala Leu Gly Glu Gln Glu Glu Thr Asp Ile Lys 
        35                  40                  45              


Phe Leu Gln Val Lys His Glu Glu Val Gly Ala Met Ala Ala Val Met 
    50                  55                  60                  


Gln Trp Lys Phe Gly Gly Lys Leu Gly Val Cys Val Gly Ser Gly Gly 
65                  70                  75                  80  


Pro Gly Ala Ser His Leu Ile Asn Gly Leu Tyr Asp Ala Ala Met Asp 
                85                  90                  95      


Asn Thr Pro Val Leu Ala Ile Leu Gly Ser Pro Pro Gln Arg Glu Leu 
            100                 105                 110         


Asn Met Asp Ala Phe Gln Glu Leu Asn Gln Asn Pro Met Tyr Asp His 
        115                 120                 125             


Ile Ala Val Tyr Asn Arg Arg Val Ala Tyr Ala Glu Gln Leu Pro Lys 
    130                 135                 140                 


Leu Ile Asp Asp Ala Ile Arg Thr Ala Ile Ser Lys Arg Gly Val Ala 
145                 150                 155                 160 


Val Leu Glu Val Pro Gly Asp Phe Gly Tyr Lys Glu Ile Ala Asn Asp 
                165                 170                 175     


Ala Phe Tyr Ser Ser Gly His Ser Tyr Arg Asp Tyr Val Ser Ser Ala 
            180                 185                 190         


Ile Asn Glu Val Asp Ile Asp Ala Ala Val Glu Val Leu Asn Lys Ser 
        195                 200                 205             


Lys Arg Ala Val Ile Tyr Ala Gly Ile Gly Thr Met Gly His Gly Pro 
    210                 215                 220                 


Ala Val Gln Glu Leu Ser Arg Lys Ile Lys Ala Pro Ile Ile Thr Thr 
225                 230                 235                 240 


Ala Lys Asn Phe Glu Thr Phe Asp Tyr Asp Phe Glu Gly Leu Thr Gly 
                245                 250                 255     


Ser Thr Tyr Arg Val Gly Trp Lys Pro Ala Asn Glu Ala Val Lys Glu 
            260                 265                 270         


Ala Asp Thr Val Leu Phe Val Gly Ser Asn Phe Pro Phe Ala Glu Val 
        275                 280                 285             


Glu Gly Thr Phe Ser Asn Val Glu Asn Phe Ile Gln Ile Asp Asn Asn 
    290                 295                 300                 


Pro Thr Met Leu Gly Lys Arg His Asn Ala Asp Val Ala Ile Leu Gly 
305                 310                 315                 320 


Asp Ala Gly Glu Ala Val Gln Met Leu Leu Glu Lys Val Ala Pro Val 
                325                 330                 335     


Glu Glu Ser Ala Trp Trp Asn Ala Asn Leu Lys Asn Ile Gln Asn Trp 
            340                 345                 350         


Arg Asp Tyr Met Thr Lys Leu Glu Thr Lys Glu Asn Gly Pro Leu Gln 
        355                 360                 365             


Leu Tyr Gln Val Tyr Asn Ala Ile Asn Lys Tyr Ala Asp Glu Asp Ala 
    370                 375                 380                 


Ile Tyr Ser Ile Asp Val Gly Asn Thr Thr Gln Thr Ser Ile Arg His 
385                 390                 395                 400 


Leu His Met Thr Pro Lys Asn Met Trp Arg Thr Ser Pro Leu Phe Ala 
                405                 410                 415     


Ser Met Gly Ile Ala Leu Pro Gly Gly Ile Gly Ala Lys Asn Val Tyr 
            420                 425                 430         


Pro Glu Arg Gln Val Phe Asn Leu Met Gly Asp Gly Ala Phe Ser Met 
        435                 440                 445             


Asn Tyr Gln Asp Ile Val Thr Asn Val Arg Tyr Asn Met Pro Val Ile 
    450                 455                 460                 


Asn Val Val Phe Thr Asn Thr Glu Tyr Gly Phe Ile Lys Asn Lys Tyr 
465                 470                 475                 480 


Glu Asp Thr Asn Thr Asn Thr Phe Gly Thr Glu Phe Thr Asp Val Asp 
                485                 490                 495     


Tyr Ala Met Ile Gly Glu Ala Gln Gly Ala Val Gly Phe Thr Val Ser 
            500                 505                 510         


Arg Ile Glu Asp Met Asp Gln Val Met Ala Ala Ala Val Lys Ala Asn 
        515                 520                 525             


Lys Glu Gly Lys Thr Val Val Ile Asp Ala Lys Ile Thr Lys Asp Arg 
    530                 535                 540                 


Pro Ile Pro Val Glu Thr Leu Lys Leu Asp Pro Ala Leu Tyr Ser Glu 
545                 550                 555                 560 


Glu Glu Ile Lys Ala Tyr Lys Glu Arg Tyr Glu Ala Glu Glu Leu Val 
                565                 570                 575     


Pro Phe Ser Glu Phe Leu Lys Ala Glu Gly Leu Glu Ser Lys Val Ala 
            580                 585                 590         


Lys 
    


<210> 25
<211> 253
<212> PRT
<213> Escherichia coli

<400> 25
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      


Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          


Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              


Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  


Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  


Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      


Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         


Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             


Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 


Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 


Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     


Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         


Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             


Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 


Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 


Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu 
                245                 250             


<210> 26
<211> 762
<212> DNA
<213> Escherichia coli

<400> 26
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg       60

cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag      120

ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa      180

cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag      240

ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg      300

catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc      360

ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg      420

gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat      480

accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt      540

aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca      600

accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc      660

gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat      720

gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctgt aa                         762


<210> 27
<211> 264
<212> PRT
<213> Escherichia coli

<400> 27
Met His His His His His His Gly Gly Ser Gly Met Ser Lys Ser Asp 
1               5                   10                  15      


Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu Gln Gly Ala Thr Leu 
            20                  25                  30          


Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu Lys Ile Ala Ala Leu 
        35                  40                  45              


Met Asp Lys Pro Val Lys Leu Ala Ser His Arg Glu Phe Thr Thr Trp 
    50                  55                  60                  


Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val Cys Ser Thr Gly Ile 
65                  70                  75                  80  


Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu Leu Ala Gln Leu Gly 
                85                  90                  95      


Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly Ala Ile Gln Pro His 
            100                 105                 110         


Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala Ser Val Arg Leu Asp 
        115                 120                 125             


Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe Pro Ala Val Ala Asp 
    130                 135                 140                 


Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala Lys Ser Ile Gly Ala 
145                 150                 155                 160 


Thr Thr His Val Gly Val Thr Ala Ser Ser Asp Thr Phe Tyr Pro Gly 
                165                 170                 175     


Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val Val Arg His Phe Lys 
            180                 185                 190         


Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val Met Asn Tyr Glu Met 
        195                 200                 205             


Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser Gln Gly Leu Arg Ala 
    210                 215                 220                 


Gly Met Val Ala Gly Val Ile Val Asn Arg Thr Gln Gln Glu Ile Pro 
225                 230                 235                 240 


Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His Ala Val Lys Ile Val 
                245                 250                 255     


Val Glu Ala Ala Arg Arg Leu Leu 
            260                 


<210> 28
<211> 264
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> uridine phosphorylase

<400> 28
Met His His His His His His Gly Gly Ser Gly Met Ser Lys Ser Asp 
1               5                   10                  15      


Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu Gln Gly Ala Thr Leu 
            20                  25                  30          


Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu Lys Ile Ala Ala Leu 
        35                  40                  45              


Met Asp Lys Pro Val Lys Leu Ala Ser His Arg Glu Phe Thr Thr Trp 
    50                  55                  60                  


Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val Cys Ser Thr Gly Ile 
65                  70                  75                  80  


Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile Leu Ala Gln Leu Gly 
                85                  90                  95      


Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly Ala Ile Gln Pro His 
            100                 105                 110         


Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala Ser Val Arg Leu Asp 
        115                 120                 125             


Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe Pro Ala Val Ala Asp 
    130                 135                 140                 


Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala Lys Ser Ile Gly Ala 
145                 150                 155                 160 


Thr Thr His Val Gly Val Thr Ala Ser Ser Asp Thr Phe Tyr Pro Gly 
                165                 170                 175     


Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val Val Arg His Phe Lys 
            180                 185                 190         


Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val Met Asn Tyr Glu Met 
        195                 200                 205             


Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser Gln Gly Leu Arg Ala 
    210                 215                 220                 


Gly Met Val Ala Gly Val Ile Val Asn Arg Thr Gln Gln Glu Ile Pro 
225                 230                 235                 240 


Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His Ala Val Lys Ile Val 
                245                 250                 255     


Val Glu Ala Ala Arg Arg Leu Leu 
            260                 


<210> 29
<211> 795
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Corresponding DNA seq  28

<400> 29
atgcaccatc atcatcatca tggcggtagc ggcatgtcca agtctgatgt ttttcatctc       60

ggcctcacta aaaacgattt acaaggggct acgcttgcca tcgtccctgg cgacccggat      120

cgtgtggaaa agatcgccgc gctgatggat aagccggtta agctggcatc tcaccgcgaa      180

ttcactacct ggcgtgcaga gctggatggt aaacctgtta tcgtctgctc taccggtatc      240

ggcggcccgt ctacctctat tgctgttgaa attctggcac agctgggcat tcgcaccttc      300

ctgcgtatcg gtacaacggg cgctattcag ccgcatatta atgtgggtga tgtcctggtt      360

accacggcgt ctgtccgtct ggatggcgcg agcctgcact tcgcaccgct ggaattcccg      420

gctgtcgctg atttcgaatg tacgactgcg ctggttgaag ctgcgaaatc cattggcgcg      480

acaactcacg ttggcgtgac agcttcttct gataccttct acccaggtca ggaacgttac      540

gatacttact ctggtcgcgt agttcgtcac tttaaaggtt ctatggaaga gtggcaggcg      600

atgggcgtaa tgaactatga aatggaatct gcaaccctgc tgaccatgtg cgcaagtcag      660

ggcctgcgtg ccggtatggt agcgggtgtt atcgttaacc gcacccagca agagatcccg      720

aatgctgaga cgatgaaaca aaccgaaagc catgcggtga aaatcgtggt ggaagcggcg      780

cgtcgtctgc tgtaa                                                       795


<210> 30
<211> 264
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> uridine phosphorylase

<400> 30
Met His His His His His His Gly Gly Ser Gly Met Ser Glu Ser Asp 
1               5                   10                  15      


Ser Phe His Leu Gly Leu Thr Lys Asn Asp Leu Gln Gly Ala Thr Leu 
            20                  25                  30          


Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu Lys Ile Ala Ala Leu 
        35                  40                  45              


Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg Glu Phe Thr Thr Trp 
    50                  55                  60                  


Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val Cys Ser Thr Gly Ile 
65                  70                  75                  80  


Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile Leu Ala Gln Leu Gly 
                85                  90                  95      


Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly Ala Ile Gln Pro His 
            100                 105                 110         


Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala Ser Val Arg Leu Asp 
        115                 120                 125             


Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe Pro Ala Val Ala Asp 
    130                 135                 140                 


Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala Lys Ser Ile Gly Ala 
145                 150                 155                 160 


Thr Thr His Val Gly Val Thr Ala Ser Ser Asp Thr Phe Tyr Pro Gly 
                165                 170                 175     


Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val Val Arg His Phe Lys 
            180                 185                 190         


Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val Met Asn Tyr Glu Met 
        195                 200                 205             


Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser Gln Gly Leu Arg Ala 
    210                 215                 220                 


Gly Met Val Ala Gly Val Ile Val Asn Arg Thr Gln Gln Glu Leu Pro 
225                 230                 235                 240 


Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His Met Val Lys Ile Val 
                245                 250                 255     


Val Glu Ala Ala Arg Arg Leu Leu 
            260                 


<210> 31
<211> 264
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> uridine phosphorylase

<400> 31
Met His His His His His His Gly Gly Ser Gly Met Ser Glu Ser Asp 
1               5                   10                  15      


Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu Gln Gly Ala Thr Leu 
            20                  25                  30          


Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu Lys Ile Ala Ala Leu 
        35                  40                  45              


Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg Glu Phe Thr Thr Trp 
    50                  55                  60                  


Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val Cys Ser Thr Gly Ile 
65                  70                  75                  80  


Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile Leu Ala Gln Leu Gly 
                85                  90                  95      


Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly Ala Ile Gln Gly His 
            100                 105                 110         


Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala Ser Val Arg Leu Asp 
        115                 120                 125             


Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe Pro Ala Val Ala Asp 
    130                 135                 140                 


Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala Lys Ser Ile Gly Ala 
145                 150                 155                 160 


Thr Thr His Val Gly Val Thr Ala Ser Ser Asp Thr Phe Tyr Pro Gly 
                165                 170                 175     


Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val Val Arg Arg Phe Gln 
            180                 185                 190         


Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val Met Asn Tyr Glu Met 
        195                 200                 205             


Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser Gln Gly Leu Arg Ala 
    210                 215                 220                 


Gly Met Val Ala Gly Val Ile Val Asn Arg Thr Gln Gln Glu Leu Pro 
225                 230                 235                 240 


Asn Ala Glu Ser Met Lys Gln Val Glu Ser His Met Val Lys Ile Val 
                245                 250                 255     


Val Glu Ala Ala Arg Arg Leu Leu 
            260                 


<210> 32
<211> 309
<212> PRT
<213> Escherichia coli

<400> 32
Met Gln Asn Ala Gly Ser Leu Val Val Leu Gly Ser Ile Asn Ala Asp 
1               5                   10                  15      


His Ile Leu Asn Leu Gln Ser Phe Pro Thr Pro Gly Glu Thr Val Thr 
            20                  25                  30          


Gly Asn His Tyr Gln Val Ala Phe Gly Gly Lys Gly Ala Asn Gln Ala 
        35                  40                  45              


Val Ala Ala Gly Arg Ser Gly Ala Asn Ile Ala Phe Ile Ala Cys Thr 
    50                  55                  60                  


Gly Asp Asp Ser Ile Gly Glu Ser Val Arg Gln Gln Leu Ala Thr Asp 
65                  70                  75                  80  


Asn Ile Asp Ile Thr Pro Val Ser Val Ile Lys Gly Glu Ser Thr Gly 
                85                  90                  95      


Val Ala Leu Ile Phe Val Asn Gly Glu Gly Glu Asn Val Ile Gly Ile 
            100                 105                 110         


His Ala Gly Ala Asn Ala Ala Leu Ser Pro Ala Leu Val Glu Ala Gln 
        115                 120                 125             


Arg Glu Arg Ile Ala Asn Ala Ser Ala Leu Leu Met Gln Leu Glu Ser 
    130                 135                 140                 


Pro Leu Glu Ser Val Met Ala Ala Ala Lys Ile Ala His Gln Asn Lys 
145                 150                 155                 160 


Thr Ile Val Ala Leu Asn Pro Ala Pro Ala Arg Glu Leu Pro Asp Glu 
                165                 170                 175     


Leu Leu Ala Leu Val Asp Ile Ile Thr Pro Asn Glu Thr Glu Ala Glu 
            180                 185                 190         


Lys Leu Thr Gly Ile Arg Val Glu Asn Asp Glu Asp Ala Ala Lys Ala 
        195                 200                 205             


Ala Gln Val Leu His Glu Lys Gly Ile Arg Thr Val Leu Ile Thr Leu 
    210                 215                 220                 


Gly Ser Arg Gly Val Trp Ala Ser Val Asn Gly Glu Gly Gln Arg Val 
225                 230                 235                 240 


Pro Gly Phe Arg Val Gln Ala Val Asp Thr Ile Ala Ala Gly Asp Thr 
                245                 250                 255     


Phe Asn Gly Ala Leu Ile Thr Ala Leu Leu Glu Glu Lys Pro Leu Pro 
            260                 265                 270         


Glu Ala Ile Arg Phe Ala His Ala Ala Ala Ala Ile Ala Val Thr Arg 
        275                 280                 285             


Lys Gly Ala Gln Pro Ser Val Pro Trp Arg Glu Glu Ile Asp Ala Phe 
    290                 295                 300                 


Leu Asp Arg Gln Arg 
305                 


<210> 33
<211> 930
<212> DNA
<213> Escherichia coli

<400> 33
atgcaaaacg caggcagcct cgttgttctt ggcagcatta atgctgacca cattcttaat       60

cttcaatctt ttcctactcc aggcgaaacc gtaaccggta accactatca ggttgcattt      120

ggcggcaaag gcgcgaatca ggctgtggct gctgggcgta gcggtgcgaa tatcgcgttt      180

attgcctgta cgggtgatga cagcattggt gagagcgttc gccagcagct cgccactgat      240

aacattgata ttactccggt cagcgtgatc aaaggcgaat caacaggtgt ggcgctgatt      300

tttgttaatg gcgaaggtga gaatgtcatc ggtattcatg ccggcgctaa tgctgccctt      360

tccccggcgc tggtggaagc gcaacgtgag cgtattgcca acgcgtcagc attattaatg      420

cagctggaat caccactcga aagtgtgatg gcagcggcga aaatcgccca tcaaaataag      480

actatcgttg cgcttaaccc ggctccggct cgcgaacttc ctgacgaact gctggcgctg      540

gtggacatta ttacgccaaa cgaaacggaa gcagaaaagc tcaccggtat tcgtgttgaa      600

aatgatgaag atgcagcgaa ggcggcgcag gtactgcatg aaaaaggtat ccgtactgta      660

ctgattactt taggaagtcg tggtgtatgg gctagcgtga atggtgaagg tcagcgcgtt      720

cctggattcc gggtgcaggc tgtcgatacc attgctgccg gagatacctt taacggtgcg      780

ttaatcacgg cattgctgga agaaaaacca ttgccagagg cgattcgttt tgcccatgct      840

gccgctgcga ttgccgtaac acgtaaaggc gcacaacctt ccgtaccgtg gcgtgaagag      900

atcgacgcat ttttagacag gcagaggtaa                                       930


<210> 34
<211> 407
<212> PRT
<213> Escherichia coli

<400> 34
Met Lys Arg Ala Phe Ile Met Val Leu Asp Ser Phe Gly Ile Gly Ala 
1               5                   10                  15      


Thr Glu Asp Ala Glu Arg Phe Gly Asp Val Gly Ala Asp Thr Leu Gly 
            20                  25                  30          


His Ile Ala Glu Ala Cys Ala Lys Gly Glu Ala Asp Asn Gly Arg Lys 
        35                  40                  45              


Gly Pro Leu Asn Leu Pro Asn Leu Thr Arg Leu Gly Leu Ala Lys Ala 
    50                  55                  60                  


His Glu Gly Ser Thr Gly Phe Ile Pro Ala Gly Met Asp Gly Asn Ala 
65                  70                  75                  80  


Glu Val Ile Gly Ala Tyr Ala Trp Ala His Glu Met Ser Ser Gly Lys 
                85                  90                  95      


Asp Thr Pro Ser Gly His Trp Glu Ile Ala Gly Val Pro Val Leu Phe 
            100                 105                 110         


Glu Trp Gly Tyr Phe Ser Asp His Glu Asn Ser Phe Pro Gln Glu Leu 
        115                 120                 125             


Leu Asp Lys Leu Val Glu Arg Ala Asn Leu Pro Gly Tyr Leu Gly Asn 
    130                 135                 140                 


Cys His Ser Ser Gly Thr Val Ile Leu Asp Gln Leu Gly Glu Glu His 
145                 150                 155                 160 


Met Lys Thr Gly Lys Pro Ile Phe Tyr Thr Ser Ala Asp Ser Val Phe 
                165                 170                 175     


Gln Ile Ala Cys His Glu Glu Thr Phe Gly Leu Asp Lys Leu Tyr Glu 
            180                 185                 190         


Leu Cys Glu Ile Ala Arg Glu Glu Leu Thr Asn Gly Gly Tyr Asn Ile 
        195                 200                 205             


Gly Arg Val Ile Ala Arg Pro Phe Ile Gly Asp Lys Ala Gly Asn Phe 
    210                 215                 220                 


Gln Arg Thr Gly Asn Arg His Asp Leu Ala Val Glu Pro Pro Ala Pro 
225                 230                 235                 240 


Thr Val Leu Gln Lys Leu Val Asp Glu Lys His Gly Gln Val Val Ser 
                245                 250                 255     


Val Gly Lys Ile Ala Asp Ile Tyr Ala Asn Cys Gly Ile Thr Lys Lys 
            260                 265                 270         


Val Lys Ala Thr Gly Leu Asp Ala Leu Phe Asp Ala Thr Ile Lys Glu 
        275                 280                 285             


Met Lys Glu Ala Gly Asp Asn Thr Ile Val Phe Thr Asn Phe Val Asp 
    290                 295                 300                 


Phe Asp Ser Ser Trp Gly His Arg Arg Asp Val Ala Gly Tyr Ala Ala 
305                 310                 315                 320 


Gly Leu Glu Leu Phe Asp Arg Arg Leu Pro Glu Leu Met Ser Leu Leu 
                325                 330                 335     


Arg Asp Asp Asp Ile Leu Ile Leu Thr Ala Asp His Gly Cys Asp Pro 
            340                 345                 350         


Thr Trp Thr Gly Thr Asp His Thr Arg Glu His Ile Pro Val Leu Val 
        355                 360                 365             


Tyr Gly Pro Lys Val Lys Pro Gly Ser Leu Gly His Arg Glu Thr Phe 
    370                 375                 380                 


Ala Asp Ile Gly Gln Thr Leu Ala Lys Tyr Phe Gly Thr Ser Asp Met 
385                 390                 395                 400 


Glu Tyr Gly Lys Ala Met Phe 
                405         


<210> 35
<211> 1224
<212> DNA
<213> Escherichia coli

<400> 35
atgaaacgtg catttattat ggtgctggac tcattcggca tcggcgctac agaagatgca       60

gaacgctttg gtgacgtcgg ggctgacacc ctgggtcata tcgcagaagc ttgtgccaaa      120

ggcgaagctg ataacggtcg taaaggcccg ctcaatctgc caaatctgac ccgtctgggg      180

ctggcgaaag cacacgaagg ttctaccggt ttcattccgg cgggaatgga cggcaacgct      240

gaagttatcg gcgcgtacgc atgggcgcac gaaatgtcat ccggtaaaga taccccgtct      300

ggtcactggg aaattgccgg tgtcccggtt ctgtttgagt ggggatattt ctccgatcac      360

gaaaacagct tcccgcaaga gctgctggat aaactggtcg aacgcgctaa tctgccgggt      420

tacctcggta actgccactc ttccggtacg gtcattctgg atcaactggg cgaagagcac      480

atgaaaaccg gcaagccgat tttctatacc tccgctgact ccgtgttcca gattgcctgc      540

catgaagaaa ctttcggtct ggataaactc tacgaactgt gcgaaatcgc ccgtgaagag      600

ctgaccaacg gcggctacaa tatcggtcgt gttatcgctc gtccgtttat cggcgacaaa      660

gccggtaact tccagcgtac cggtaaccgt cacgacctgg ctgttgagcc gccagcaccg      720

accgtgctgc agaaactggt tgatgaaaaa cacggccagg tggtttctgt cggtaaaatt      780

gcggacatct acgccaactg cggtatcacc aaaaaagtga aagcgactgg cctggacgcg      840

ctgtttgacg ccaccatcaa agagatgaaa gaagcgggtg ataacaccat cgtcttcacc      900

aacttcgttg acttcgactc ttcctggggc caccgtcgcg acgtcgccgg ttatgccgcg      960

ggtctggaac tgttcgaccg ccgtctgccg gagctgatgt ctctgctgcg cgatgacgac     1020

atcctgatcc tcaccgctga ccacggttgc gatccgacct ggaccggtac tgaccacacg     1080

cgtgaacaca ttccggtact ggtatatggc ccgaaagtaa aaccgggctc actgggtcat     1140

cgtgaaacct tcgcggatat cggccagact ctggcaaaat attttggtac ttctgatatg     1200

gaatatggca aagccatgtt ctaa                                            1224


<210> 36
<211> 413
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> phosphopentomutase

<400> 36
Met Lys Arg Ala Phe Ile Met Val Leu Asp Ser Phe Gly Ile Gly Ala 
1               5                   10                  15      


Thr Glu Asp Ala Glu Arg Phe Gly Asp Val Gly Ala Asp Thr Leu Gly 
            20                  25                  30          


His Ile Ala Glu Ala Cys Ala Lys Gly Glu Ala Asp Asn Gly Arg Lys 
        35                  40                  45              


Gly Pro Leu Asn Leu Pro Asn Leu Thr Arg Leu Gly Leu Ala Lys Ala 
    50                  55                  60                  


His Glu Gly Ser Thr Gly Phe Ile Pro Ala Gly Met Asp Gly Asn Ala 
65                  70                  75                  80  


Glu Val Ile Gly Ala Tyr Ala Trp Ala His Glu Met Ser Ser Gly Lys 
                85                  90                  95      


Asp Thr Pro Ser Gly His Trp Glu Ile Ala Gly Val Pro Val Leu Phe 
            100                 105                 110         


Glu Trp Gly Tyr Phe Ser Asp His Glu Asn Ser Phe Pro Gln Glu Leu 
        115                 120                 125             


Leu Asp Lys Leu Val Glu Arg Ala Asn Leu Pro Gly Tyr Leu Gly Asn 
    130                 135                 140                 


Cys His Ser Ser Gly Thr Val Ile Leu Asp Gln Leu Gly Glu Glu His 
145                 150                 155                 160 


Met Lys Thr Gly Lys Pro Ile Phe Tyr Thr Ser Ala Asp Ser Val Phe 
                165                 170                 175     


Gln Ile Ala Cys His Glu Glu Thr Phe Gly Leu Asp Lys Leu Tyr Glu 
            180                 185                 190         


Leu Cys Glu Ile Ala Arg Glu Glu Leu Thr Asn Gly Gly Tyr Asn Ile 
        195                 200                 205             


Gly Arg Val Ile Ala Arg Pro Phe Ile Gly Asp Lys Ala Gly Asn Phe 
    210                 215                 220                 


Gln Arg Thr Gly Asn Arg Arg Asp Leu Ala Val Glu Pro Pro Ala Pro 
225                 230                 235                 240 


Thr Val Leu Gln Lys Leu Val Asp Glu Lys His Gly Gln Val Val Ser 
                245                 250                 255     


Val Gly Lys Ile Ala Asp Ile Tyr Ala Asn Cys Gly Ile Thr Lys Lys 
            260                 265                 270         


Val Lys Ala Thr Gly Leu Asp Ala Leu Phe Asp Ala Thr Ile Lys Glu 
        275                 280                 285             


Met Lys Glu Ala Gly Asp Asn Thr Ile Val Phe Thr Asn Phe Val Asp 
    290                 295                 300                 


Phe Asp Ser Ser Trp Gly His Arg Arg Asp Val Ala Gly Tyr Ala Ala 
305                 310                 315                 320 


Gly Leu Glu Leu Phe Asp Arg Arg Leu Pro Glu Leu Met Ser Leu Leu 
                325                 330                 335     


Arg Asp Asp Asp Ile Leu Ile Leu Thr Ala Asp His Gly Cys Asp Pro 
            340                 345                 350         


Thr Trp Thr Gly Thr Asp His Thr Arg Glu His Ile Pro Val Leu Val 
        355                 360                 365             


Tyr Gly Pro Lys Val Lys Pro Gly Ser Leu Gly His Arg Glu Thr Phe 
    370                 375                 380                 


Ala Asp Ile Gly Gln Thr Leu Ala Lys Tyr Phe Gly Thr Ser Asp Met 
385                 390                 395                 400 


Glu Tyr Gly Lys Ala Met Phe His His His His His His 
                405                 410             


<210> 37
<211> 1242
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Corresponding DNA seq  36

<400> 37
atgaaacgtg catttattat ggtgctggac tcattcggca tcggcgctac agaagatgca       60

gaacgctttg gtgacgtcgg ggctgacacc ctgggtcata tcgcagaagc ttgtgccaaa      120

ggcgaagctg ataacggtcg taaaggcccg ctcaatctgc caaatctgac ccgtctgggg      180

ctggcgaaag cacacgaagg ttctaccggt ttcattccgg cgggaatgga cggcaacgct      240

gaagttatcg gcgcgtacgc atgggcgcac gaaatgtcat ccggtaaaga taccccgtct      300

ggtcactggg aaattgccgg tgtcccggtt ctgtttgagt ggggatattt ctccgatcac      360

gaaaacagct tcccgcaaga gctgctggat aaactggtcg aacgcgctaa tctgccgggt      420

tacctcggta actgccactc ttccggtacg gtcattctgg atcaactggg cgaagagcac      480

atgaaaaccg gcaagccgat tttctatacc tccgctgact ccgtgttcca gattgcctgc      540

catgaagaaa ctttcggtct ggataaactc tacgaactgt gcgaaatcgc ccgtgaagag      600

ctgaccaacg gcggctacaa tatcggtcgt gttatcgctc gtccgtttat cggcgacaaa      660

gccggtaact tccagcgtac cggtaaccgt cgtgacctgg ctgttgagcc gccagcaccg      720

accgtgctgc agaaactggt tgatgaaaaa cacggccagg tggtttctgt cggtaaaatt      780

gcggacatct acgccaactg cggtatcacc aaaaaagtga aagcgactgg cctggacgcg      840

ctgtttgacg ccaccatcaa agagatgaaa gaagcgggtg ataacaccat cgtcttcacc      900

aacttcgttg acttcgactc ttcctggggc caccgtcgcg acgtcgccgg ttatgccgcg      960

ggtctggaac tgttcgaccg ccgtctgccg gagctgatgt ctctgctgcg cgatgacgac     1020

atcctgatcc tcaccgctga ccacggttgc gatccgacct ggaccggtac tgaccacacg     1080

cgtgaacaca ttccggtact ggtatatggc ccgaaagtaa aaccgggctc actgggtcat     1140

cgtgaaacct tcgcggatat cggccagact ctggcaaaat attttggtac ttctgatatg     1200

gaatatggca aagccatgtt ccatcatcat caccatcatt aa                        1242


<210> 38
<211> 413
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> phosphopentomutase

<400> 38
Met Lys Arg Ala Phe Ile Met Val Leu Asp Ser Phe Gly Ile Gly Ala 
1               5                   10                  15      


Thr Glu Asp Ala Glu Lys Phe Gly Asp Val Gly Ala Asp Thr Leu Gly 
            20                  25                  30          


His Ile Ala Glu Ala Cys Ala Lys Gly Glu Ala Asp Asn Gly Arg Lys 
        35                  40                  45              


Gly Pro Leu Asn Val Pro Asn Leu Thr Arg Leu Gly Leu Ala Lys Ala 
    50                  55                  60                  


His Glu Gly Ser Thr Gly Phe Ile Pro Ala Gly Met Asp Gly Asn Ala 
65                  70                  75                  80  


Glu Val Ile Gly Ala Tyr Ala Trp Ala His Glu Met Ser Ser Gly Lys 
                85                  90                  95      


Asp Thr Pro Ser Gly His Trp Glu Ile Ala Gly Val Pro Val Leu Phe 
            100                 105                 110         


Glu Trp Gly Tyr Phe Ser Asp Leu Glu Asn Ser Phe Pro Gln Glu Leu 
        115                 120                 125             


Leu Asp Lys Leu Val Glu Arg Ala Asn Leu Pro Gly Tyr Leu Gly Asn 
    130                 135                 140                 


Cys His Ser Ser Gly Thr Val Ile Leu Asp Gln Leu Gly Glu Glu His 
145                 150                 155                 160 


Met Lys Thr Gly Lys Pro Ile Phe Tyr Thr Ser Ala Asp Ser Val Phe 
                165                 170                 175     


Gln Ile Ala Cys His Glu Glu Thr Phe Gly Leu Asp Lys Leu Tyr Glu 
            180                 185                 190         


Leu Cys Glu Ile Ala Arg Glu Glu Leu Thr Asn Gly Gly Tyr Asn Ile 
        195                 200                 205             


Gly Arg Val Ile Ala Arg Pro Phe Ile Gly Asp Lys Ala Gly Asn Phe 
    210                 215                 220                 


Gln Arg Thr Gly Asn Arg Arg Asp Leu Ala Val Glu Pro Pro Ala Pro 
225                 230                 235                 240 


Thr Val Leu Gln Lys Leu Val Asp Glu Lys His Gly Gln Val Val Gly 
                245                 250                 255     


Val Gly Lys Ile Ala Asp Ile Tyr Ala Asn Cys Gly Ile Thr Lys Lys 
            260                 265                 270         


Val Lys Ala Thr Gly Leu Asp Ala Leu Phe Asp Thr Thr Ile Lys Glu 
        275                 280                 285             


Met Lys Glu Ala Gly Asp Asn Thr Ile Val Phe Thr Asn Phe Val Asp 
    290                 295                 300                 


Phe Asp Ser Ser Trp Gly His Arg Arg Asp Val Ala Gly Tyr Ala Ala 
305                 310                 315                 320 


Gly Leu Glu Leu Phe Asp Arg Arg Leu Pro Glu Leu Met Ser Leu Leu 
                325                 330                 335     


Arg Asp Asp Asp Ile Leu Ile Leu Thr Ala Asp His Gly Cys Asp Pro 
            340                 345                 350         


Thr Trp Thr Gly Thr Asp His Thr Arg Glu His Ile Pro Val Leu Val 
        355                 360                 365             


Tyr Gly Pro Lys Val Lys Pro Gly Ser Leu Gly His Arg Glu Thr Phe 
    370                 375                 380                 


Ala Asp Ile Gly Gln Thr Leu Ala Lys Tyr Phe Gly Thr Ser Asp Met 
385                 390                 395                 400 


Glu Tyr Gly Lys Ala Met Phe His His His His His His 
                405                 410             


<210> 39
<211> 1242
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Corresponding DNA seq 38

<400> 39
atgaaacgtg catttattat ggtgctggac tcattcggca tcggcgctac agaagatgca       60

gaaaagtttg gtgacgtcgg ggctgacacc ctgggtcata tcgcagaagc ttgtgccaaa      120

ggcgaagctg ataacggtcg taaaggcccg ctcaatgtgc caaatctgac ccgtctgggg      180

ctggcgaaag cgcacgaagg ctctaccggt ttcattccgg cgggaatgga cggcaacgct      240

gaagttatcg gcgcgtacgc atgggcgcac gaaatgtcat ccggtaaaga taccccgtct      300

ggtcactggg aaattgccgg tgtcccggtt ctgttcgagt ggggatattt ctccgatctg      360

gaaaacagct tcccgcaaga gctgctggat aaactggtcg aacgcgctaa tctgccgggt      420

tacctcggta actgccactc ttccggtacg gtcattctgg atcaactggg cgaagagcac      480

atgaaaaccg gcaagccgat tttctatacc tccgctgact ccgtgttcca gattgcctgc      540

catgaagaaa ctttcggtct ggataaactc tacgaactgt gcgaaatcgc ccgtgaagag      600

ctgaccaacg gcggctacaa tatcggtcgt gttatcgctc gtccgtttat cggcgacaaa      660

gccggtaact tccagcgtac cggtaaccgt cgtgacctgg ctgttgagcc gccagcaccg      720

accgtgctgc agaaactggt tgatgaaaaa cacggccagg tggtaggcgt cggtaaaatt      780

gcggacatct acgccaactg cggtatcacc aaaaaagtga aagcgactgg cctggacgcg      840

ctgtttgaca ctaccatcaa agagatgaaa gaagcgggtg ataacaccat cgtcttcacc      900

aacttcgttg acttcgactc ttcctggggc caccgtcgcg acgtcgccgg ttatgccgcg      960

ggtctggaac tgttcgaccg ccgtctgccg gagctgatgt ctctgctgcg cgatgacgac     1020

atcctgatcc tcaccgctga ccacggttgc gatccgacct ggaccggtac tgaccacacg     1080

cgtgaacaca ttccggtact ggtatatggc ccgaaagtaa aaccgggctc actgggtcat     1140

cgtgaaacct tcgcggatat cggccagact ctggcaaaat attttggtac ttctgatatg     1200

gaatatggca aagccatgtt ccatcatcat caccatcatt aa                        1242


<210> 40
<211> 500
<212> PRT
<213> Alloscardovia omnicolens

<400> 40
Met Lys Asn Lys Val Gln Leu Ile Thr Tyr Ala Asp Arg Leu Gly Asp 
1               5                   10                  15      


Gly Thr Leu Lys Ser Met Thr Glu Thr Leu Arg Lys His Phe Glu Gly 
            20                  25                  30          


Val Tyr Glu Gly Val His Ile Leu Pro Phe Phe Thr Pro Phe Asp Gly 
        35                  40                  45              


Ala Asp Ala Gly Phe Asp Pro Val Asp His Thr Lys Val Asp Pro Arg 
    50                  55                  60                  


Leu Gly Ser Trp Asp Asp Val Ala Glu Leu Ser Thr Thr His Asp Ile 
65                  70                  75                  80  


Met Val Asp Thr Ile Val Asn His Met Ser Trp Glu Ser Glu Gln Phe 
                85                  90                  95      


Gln Asp Val Met Ala Lys Gly Glu Asp Ser Glu Tyr Tyr Pro Met Phe 
            100                 105                 110         


Leu Thr Met Ser Ser Ile Phe Pro Asp Gly Val Thr Glu Glu Asp Leu 
        115                 120                 125             


Thr Ala Ile Tyr Arg Pro Arg Pro Gly Leu Pro Phe Thr His Tyr Asn 
    130                 135                 140                 


Trp Gly Gly Lys Thr Arg Leu Val Trp Thr Thr Phe Thr Pro Gln Gln 
145                 150                 155                 160 


Val Asp Ile Asp Thr Asp Ser Glu Met Gly Trp Asn Tyr Leu Leu Ser 
                165                 170                 175     


Ile Leu Asp Gln Leu Ser Gln Ser His Val Ser Gln Ile Arg Leu Asp 
            180                 185                 190         


Ala Val Gly Tyr Gly Ala Lys Glu Lys Asn Ser Ser Cys Phe Met Thr 
        195                 200                 205             


Pro Lys Thr Phe Lys Leu Ile Glu Arg Ile Lys Ala Glu Gly Glu Lys 
    210                 215                 220                 


Arg Gly Leu Glu Thr Leu Ile Glu Val His Ser Tyr Tyr Lys Lys Gln 
225                 230                 235                 240 


Val Glu Ile Ala Ser Lys Val Asp Arg Val Tyr Asp Phe Ala Ile Pro 
                245                 250                 255     


Gly Leu Leu Leu His Ala Leu Glu Phe Gly Lys Thr Asp Ala Leu Ala 
            260                 265                 270         


Gln Trp Ile Asp Val Arg Pro Asn Asn Ala Val Asn Val Leu Asp Thr 
        275                 280                 285             


His Asp Gly Ile Gly Val Ile Asp Ile Gly Ser Asp Gln Met Asp Arg 
    290                 295                 300                 


Ser Leu Ala Gly Leu Val Pro Asp Glu Glu Val Asp Ala Leu Val Glu 
305                 310                 315                 320 


Ser Ile His Arg Asn Ser Lys Gly Glu Ser Gln Glu Ala Thr Gly Ala 
                325                 330                 335     


Ala Ala Ser Asn Leu Asp Leu Tyr Gln Val Asn Cys Thr Tyr Tyr Ala 
            340                 345                 350         


Ala Leu Gly Ser Asp Asp Gln Lys Tyr Ile Ala Ala Arg Ala Val Gln 
        355                 360                 365             


Phe Phe Met Pro Gly Val Pro Gln Val Tyr Tyr Val Gly Ala Leu Ala 
    370                 375                 380                 


Gly Ser Asn Asp Met Asp Leu Leu Lys Arg Thr Asn Val Gly Arg Asp 
385                 390                 395                 400 


Ile Asn Arg His Tyr Tyr Ser Ala Ala Glu Val Ala Ser Glu Val Glu 
                405                 410                 415     


Arg Pro Val Val Gln Ala Leu Asn Ala Leu Gly Arg Phe Arg Asn Thr 
            420                 425                 430         


Leu Ser Ala Phe Asp Gly Glu Phe Ser Tyr Ser Asn Ala Asp Gly Val 
        435                 440                 445             


Leu Thr Met Thr Trp Ala Asp Asp Ala Thr Arg Ala Thr Leu Thr Phe 
    450                 455                 460                 


Ala Pro Lys Ala Asn Ser Asn Gly Ala Ser Val Ala Arg Leu Glu Trp 
465                 470                 475                 480 


Thr Asp Ala Ala Gly Glu His Ala Thr Asp Asp Leu Ile Ala Asn Pro 
                485                 490                 495     


Pro Val Val Ala 
            500 


<210> 41
<211> 500
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> sucrose phosphorylase SUP-101

<400> 41
Met Lys Asn Lys Val Gln Leu Ile Thr Tyr Ala Asp Arg Leu Gly Asp 
1               5                   10                  15      


Gly Thr Leu Lys Ser Met Thr Glu Thr Leu Arg Lys His Phe Glu Gly 
            20                  25                  30          


Val Tyr Glu Gly Val His Ile Leu Pro Phe Phe Thr Pro Phe Asp Gly 
        35                  40                  45              


Ala Asp Ala Gly Phe Asp Pro Val Asp His Thr Lys Val Asp Pro Arg 
    50                  55                  60                  


Leu Gly Ser Trp Asp Asp Val Ala Glu Leu Ser Thr Thr His Asp Ile 
65                  70                  75                  80  


Met Val Asp Thr Ile Val Asn His Met Ser Trp Glu Ser Glu Gln Phe 
                85                  90                  95      


Gln Asp Val Met Ala Lys Gly Glu Asp Ser Glu Tyr Tyr Pro Met Phe 
            100                 105                 110         


Leu Thr Met Ser Ser Ile Phe Pro Asp Gly Val Thr Glu Glu Asp Leu 
        115                 120                 125             


Thr Ala Ile Tyr Arg Pro Arg Pro Gly Leu Pro Phe Thr His Tyr Asn 
    130                 135                 140                 


Trp Gly Gly Lys Thr Arg Leu Val Trp Thr Thr Phe Thr Arg Gln Gln 
145                 150                 155                 160 


Val Asp Ile Asp Thr Asp Ser Glu Met Gly Trp Asn Tyr Leu Leu Ser 
                165                 170                 175     


Ile Leu Asp Gln Leu Ser Gln Ser His Val Ser Gln Ile Arg Leu Asp 
            180                 185                 190         


Ala Val Gly Tyr Gly Ala Lys Glu Lys Asn Ser Ser Cys Phe Leu Thr 
        195                 200                 205             


Pro Lys Thr Phe Lys Leu Val Glu Arg Ile Lys Ala Glu Gly Glu Lys 
    210                 215                 220                 


Arg Gly Leu Glu Thr Leu Ile Glu Val His Ser Tyr Tyr Lys Lys Gln 
225                 230                 235                 240 


Val Glu Ile Ala Ser Lys Val Asp Arg Val Tyr Asp Phe Ala Ile Pro 
                245                 250                 255     


Gly Leu Leu Leu His Ala Leu Glu Phe Gly Lys Thr Asp Ala Leu Ala 
            260                 265                 270         


Gln Trp Ile Asp Val Arg Pro Asn Asn Ala Val Asn Val Leu Asp Thr 
        275                 280                 285             


His Asp Gly Ile Gly Val Ile Asp Ile Gly Ser Asp Gln Met Asp Arg 
    290                 295                 300                 


Ser Leu Ala Gly Leu Val Pro Asp Glu Glu Val Asp Ala Leu Val Glu 
305                 310                 315                 320 


Ser Ile His Arg Asn Ser Lys Gly Glu Ser Gln Glu Ala Thr Gly Ala 
                325                 330                 335     


Ala Ala Ser Asn Leu Asp Leu Tyr Gln Val Asn Cys Thr Tyr Tyr Ala 
            340                 345                 350         


Ala Leu Gly Ser Asp Asp Gln Lys Tyr Ile Ala Ala Arg Ala Val Gln 
        355                 360                 365             


Phe Phe Met Pro Gly Val Pro Gln Val Tyr Tyr Val Gly Ala Leu Ala 
    370                 375                 380                 


Gly Ser Asn Asp Met Asp Leu Leu Lys Arg Thr Asn Ser Gly Arg Gly 
385                 390                 395                 400 


Ile Asn Arg His Tyr Tyr Ser Ala Ala Glu Val Ala Ser Glu Val Glu 
                405                 410                 415     


Arg Pro Val Val Gln Ala Leu Asn Ala Leu Gly Arg Phe Arg Asn Thr 
            420                 425                 430         


Leu Ser Ala Phe Asp Gly Glu Phe Ser Tyr Ser Asn Ala Asp Gly Val 
        435                 440                 445             


Leu Thr Met Thr Trp Ala Asp Asp Ala Thr Arg Ala Thr Leu Thr Phe 
    450                 455                 460                 


Ala Pro Lys Ala Asn Ser Asn Gly Ala Ser Val Ala Arg Leu Glu Trp 
465                 470                 475                 480 


Thr Asp Ala Ala Gly Glu His Ala Thr Asp Asp Leu Ile Ala Asn Pro 
                485                 490                 495     


Pro Val Val Ala 
            500 


<210> 42
<211> 1503
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Corresponding DNA seq 40

<400> 42
atgaagaaca aagttcaact gattacctat gcggatcgtc tgggtgacgg caccctgaag       60

agcatgaccg agaccctgcg taaacacttc gagggtgttt atgaaggcgt gcacatcctg      120

ccgttcttta ccccgttcga tggtgcggac gcgggctttg atccggttga ccacaccaaa      180

gtggacccgc gtctgggtag ctgggacgat gtggcggaac tgagcaccac ccacgatatc      240

atggttgaca ccattgtgaa ccacatgagc tgggagagcg aacagttcca agatgttatg      300

gcgaagggcg aggacagcga atactatccg atgttcctga ccatgagcag catttttccg      360

gatggtgtga ccgaggaaga cctgaccgcg atctatcgtc cgcgtccggg tctgccgttc      420

acccactata actggggtgg caaaacccgt ctggtttgga ccacctttac ccgtcagcaa      480

gtggacattg ataccgacag cgagatgggt tggaactacc tgctgagcat cctggatcag      540

ctgagccaaa gccacgttag ccaaattcgt ctggacgcgg tgggttatgg cgcgaaggag      600

aaaaacagca gctgcttcct gaccccgaag acctttaaac tggtcgaacg tattaaggcg      660

gagggtgaaa aacgtggcct ggagaccctg atcgaagttc acagctacta taagaaacag      720

gtggagattg cgagcaaggt ggatcgtgtt tacgactttg cgatcccggg tctgctgctg      780

catgcgctgg aatttggcaa aaccgatgcg ctggcgcaat ggattgacgt tcgtccgaac      840

aacgcggtga acgttctgga tacccacgac ggtatcggcg ttatcgatat tggtagcgat      900

cagatggacc gtagcctggc gggtctggtg ccggatgagg aagttgacgc gctggttgag      960

agcatccacc gtaacagcaa gggtgaaagc caggaagcga ccggcgcggc ggcgagcaac     1020

ctggacctgt accaagttaa ctgcacctac tatgcggcgc tgggtagcga cgatcagaaa     1080

tatattgcgg cgcgtgcggt gcagttcttt atgccgggcg tgccgcaagt ttactatgtg     1140

ggtgcgctgg cgggcagcaa cgatatggac ctgctgaagc gtaccaacag tggtcgtggc     1200

atcaaccgtc actactatag cgcggcggaa gtggcgagcg aggtggaacg tccggtggtt     1260

caggcgctga acgcgctggg ccgtttccgt aacaccctga gcgcgttcga tggtgaattt     1320

agctacagca acgcggacgg cgttctgacc atgacctggg cggatgatgc gacccgtgcg     1380

accctgacct ttgcgccgaa ggcgaacagc aacggtgcga gcgtggcgcg tctggagtgg     1440

accgatgcgg cgggtgaaca tgcgaccgac gatctgatcg cgaacccgcc ggtggttgcg     1500

taa                                                                   1503


<210> 43
<211> 510
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> sucrose phosphorylase SUP-101

<400> 43
Met Lys Asn Lys Val Gln Leu Ile Thr Tyr Ala Asp Arg Leu Gly Asp 
1               5                   10                  15      


Gly Thr Leu Lys Ser Met Thr Glu Thr Leu Arg Lys His Phe Glu Gly 
            20                  25                  30          


Val Tyr Glu Gly Val His Ile Leu Pro Phe Phe Thr Pro Phe Asp Gly 
        35                  40                  45              


Ala Asp Ala Gly Phe Asp Pro Val Asp His Thr Lys Val Asp Pro Arg 
    50                  55                  60                  


Leu Gly Ser Trp Asp Asp Val Ala Glu Leu Ser Thr Thr His Asp Ile 
65                  70                  75                  80  


Met Val Asp Thr Ile Val Asn His Met Ser Trp Glu Ser Glu Gln Phe 
                85                  90                  95      


Gln Asp Val Met Ala Lys Gly Glu Asp Ser Glu Tyr Tyr Pro Met Phe 
            100                 105                 110         


Leu Thr Met Ser Ser Ile Phe Pro Asp Gly Val Thr Glu Glu Asp Leu 
        115                 120                 125             


Thr Ala Ile Tyr Arg Pro Arg Pro Gly Leu Pro Phe Thr His Tyr Asn 
    130                 135                 140                 


Trp Gly Gly Lys Thr Arg Leu Val Trp Thr Thr Phe Thr Arg Gln Gln 
145                 150                 155                 160 


Val Asp Ile Asp Thr Asp Ser Glu Met Gly Trp Asn Tyr Leu Leu Ser 
                165                 170                 175     


Ile Leu Asp Gln Leu Ser Gln Ser His Val Ser Gln Ile Arg Leu Asp 
            180                 185                 190         


Ala Val Gly Tyr Gly Ala Lys Glu Lys Asn Ser Ser Cys Phe Leu Thr 
        195                 200                 205             


Pro Lys Thr Phe Lys Leu Val Glu Arg Ile Lys Ala Glu Gly Glu Lys 
    210                 215                 220                 


Arg Gly Leu Glu Thr Leu Ile Glu Val His Ser Tyr Tyr Lys Lys Gln 
225                 230                 235                 240 


Val Glu Ile Ala Ser Lys Val Asp Arg Val Tyr Asp Phe Ala Ile Pro 
                245                 250                 255     


Gly Leu Leu Leu His Ala Leu Glu Phe Gly Lys Thr Asp Ala Leu Ala 
            260                 265                 270         


Gln Trp Ile Asp Val Arg Pro Asn Asn Ala Val Asn Val Leu Asp Thr 
        275                 280                 285             


His Asp Gly Ile Gly Val Ile Asp Ile Gly Ser Asp Gln Met Asp Arg 
    290                 295                 300                 


Ser Leu Ala Gly Leu Val Pro Asp Glu Glu Val Asp Ala Leu Val Glu 
305                 310                 315                 320 


Ser Ile His Arg Asn Ser Lys Gly Glu Ser Gln Glu Ala Thr Gly Ala 
                325                 330                 335     


Ala Ala Ser Asn Leu Asp Leu Tyr Gln Val Asn Cys Thr Tyr Tyr Ala 
            340                 345                 350         


Ala Leu Gly Ser Asp Asp Gln Lys Tyr Ile Ala Ala Arg Ala Val Gln 
        355                 360                 365             


Phe Phe Met Pro Gly Val Pro Gln Val Tyr Tyr Val Gly Ala Leu Ala 
    370                 375                 380                 


Gly Ser Asn Asp Met Asp Leu Leu Lys Arg Thr Asn Ser Gly Arg Gly 
385                 390                 395                 400 


Ile Asn Arg His Tyr Tyr Ser Ala Ala Glu Val Ala Ser Glu Val Glu 
                405                 410                 415     


Arg Pro Val Val Gln Ala Leu Asn Ala Leu Gly Arg Phe Arg Asn Thr 
            420                 425                 430         


Leu Ser Ala Phe Asp Gly Glu Phe Ser Tyr Ser Asn Ala Asp Gly Val 
        435                 440                 445             


Leu Thr Met Thr Trp Ala Asp Asp Ala Thr Arg Ala Thr Leu Thr Phe 
    450                 455                 460                 


Ala Pro Lys Ala Asn Ser Asn Gly Ala Ser Val Ala Arg Leu Glu Trp 
465                 470                 475                 480 


Thr Asp Ala Ala Gly Glu His Ala Thr Asp Asp Leu Ile Ala Asn Pro 
                485                 490                 495     


Pro Val Val Ala Gly Gln Thr Gly His His His His His His 
            500                 505                 510 


<210> 44
<211> 1536
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Corresponding DNA seq  43

<400> 44
atgaagaaca aagttcaact gattacctat gcggatcgtc tgggtgacgg caccctgaag       60

agcatgaccg agaccctgcg taaacacttc gagggtgttt atgaaggcgt gcacatcctg      120

ccgttcttta ccccgttcga tggtgcggac gcgggctttg atccggttga ccacaccaaa      180

gtggacccgc gtctgggtag ctgggacgat gtggcggaac tgagcaccac ccacgatatc      240

atggttgaca ccattgtgaa ccacatgagc tgggagagcg aacagttcca agatgttatg      300

gcgaagggcg aggacagcga atactatccg atgttcctga ccatgagcag catttttccg      360

gatggtgtga ccgaggaaga cctgaccgcg atctatcgtc cgcgtccggg tctgccgttc      420

acccactata actggggtgg caaaacccgt ctggtttgga ccacctttac ccgtcagcaa      480

gtggacattg ataccgacag cgagatgggt tggaactacc tgctgagcat cctggatcag      540

ctgagccaaa gccacgttag ccaaattcgt ctggacgcgg tgggttatgg cgcgaaggag      600

aaaaacagca gctgcttcct gaccccgaag acctttaaac tggtcgaacg tattaaggcg      660

gagggtgaaa aacgtggcct ggagaccctg atcgaagttc acagctacta taagaaacag      720

gtggagattg cgagcaaggt ggatcgtgtt tacgactttg cgatcccggg tctgctgctg      780

catgcgctgg aatttggcaa aaccgatgcg ctggcgcaat ggattgacgt tcgtccgaac      840

aacgcggtga acgttctgga tacccacgac ggtatcggcg ttatcgatat tggtagcgat      900

cagatggacc gtagcctggc gggtctggtg ccggatgagg aagttgacgc gctggttgag      960

agcatccacc gtaacagcaa gggtgaaagc caggaagcga ccggcgcggc ggcgagcaac     1020

ctggacctgt accaagttaa ctgcacctac tatgcggcgc tgggtagcga cgatcagaaa     1080

tatattgcgg cgcgtgcggt gcagttcttt atgccgggcg tgccgcaagt ttactatgtg     1140

ggtgcgctgg cgggcagcaa cgatatggac ctgctgaagc gtaccaacag tggtcgtggc     1200

atcaaccgtc actactatag cgcggcggaa gtggcgagcg aggtggaacg tccggtggtt     1260

caggcgctga acgcgctggg ccgtttccgt aacaccctga gcgcgttcga tggtgaattt     1320

agctacagca acgcggacgg cgttctgacc atgacctggg cggatgatgc gacccgtgcg     1380

accctgacct ttgcgccgaa ggcgaacagc aacggtgcga gcgtggcgcg tctggagtgg     1440

accgatgcgg cgggtgaaca tgcgaccgac gatctgatcg cgaacccgcc ggtggttgcg     1500

ggccaaactg gccaccatca ccatcaccat tagtaa                               1536


<210> 45
<211> 264
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> uridine phosphorylase

<400> 45
Met His His His His His His Gly Gly Ser Gly Met Ser Glu Ser Asp 
1               5                   10                  15      


Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu Gln Gly Ala Thr Leu 
            20                  25                  30          


Ala Ile Val Pro Gly Asp Pro Ala Arg Val Glu Lys Ile Ala Ala Leu 
        35                  40                  45              


Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg Glu Phe Ile Thr Trp 
    50                  55                  60                  


Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val Cys Ser Thr Gly Ile 
65                  70                  75                  80  


Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile Leu Ala Gln Leu Gly 
                85                  90                  95      


Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly Ala Ile Gln Gly His 
            100                 105                 110         


Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala Ser Val Arg Leu Asp 
        115                 120                 125             


Gly Ala Ser Gly His Phe Ala Pro Tyr Glu Phe Pro Ala Val Ala Asp 
    130                 135                 140                 


Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala Lys Ser Ile Gly Ala 
145                 150                 155                 160 


Thr Thr His Val Gly Val Thr Ala Ser Ser Asp Thr Phe Tyr Pro Gly 
                165                 170                 175     


Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val Val Arg Arg Phe Gln 
            180                 185                 190         


Gly Ser Met Glu Glu Trp Arg Glu Met Gly Val Met Asn Tyr Glu Met 
        195                 200                 205             


Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser Gln Gly Leu Arg Ala 
    210                 215                 220                 


Gly Met Val Ala Gly Val Ile Val Asn Arg Thr Gln Gln Glu Leu Pro 
225                 230                 235                 240 


Asn Ala Glu Ser Met Lys Gln Val Glu Ser His Met Val Lys Ile Val 
                245                 250                 255     


Val Glu Ala Ala Arg Arg Leu Leu 
            260                 


<210> 46
<211> 264
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> uridine phosphorylase

<400> 46
Met His His His His His His Gly Gly Ser Gly Met Ser Glu Ser Asp 
1               5                   10                  15      


Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu Gln Gly Ala Thr Leu 
            20                  25                  30          


Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu Lys Ile Ala Ala Leu 
        35                  40                  45              


Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg Glu Phe Ile Thr Trp 
    50                  55                  60                  


Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val Cys Ser Thr Gly Ile 
65                  70                  75                  80  


Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile Leu Ala Gln Leu Gly 
                85                  90                  95      


Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly Ala Ile Gln Gly His 
            100                 105                 110         


Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala Ser Val Arg Leu Asp 
        115                 120                 125             


Gly Ala Ser Gly His Phe Ala Pro Tyr Glu Phe Pro Ala Val Ala Asp 
    130                 135                 140                 


Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala Lys Ser Ile Gly Ala 
145                 150                 155                 160 


Thr Thr His Val Gly Val Thr Ala Ser Ser Asp Thr Phe Tyr Pro Gly 
                165                 170                 175     


Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val Val Arg Arg Phe Gln 
            180                 185                 190         


Gly Ser Met Glu Glu Trp Arg Val Met Gly Val Met Asn Tyr Glu Met 
        195                 200                 205             


Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser Gln Gly Leu Arg Ala 
    210                 215                 220                 


Gly Met Val Ala Gly Val Ile Val Asn Arg Thr Gln Gln Glu Leu Pro 
225                 230                 235                 240 


Asn Ala Glu Asp Met Pro Gln Val Glu Ser His Met Val Lys Ile Val 
                245                 250                 255     


Val Glu Ala Ala Arg Arg Leu Leu 
            260                 


<210> 47
<211> 264
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> uridine phosphorylase

<400> 47
Met His His His His His His Gly Gly Ser Gly Met Ser Glu Ser Asp 
1               5                   10                  15      


Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu Gln Gly Ala Thr Leu 
            20                  25                  30          


Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu Lys Ile Ala Ala Leu 
        35                  40                  45              


Met Asp Asn Pro Val Lys Leu Gly Gln Trp Arg Glu Phe Ile Thr Trp 
    50                  55                  60                  


Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val Cys Ser Thr Gly Ile 
65                  70                  75                  80  


Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile Leu Ala Gln Leu Gly 
                85                  90                  95      


Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly Ala Ile Gln Gly His 
            100                 105                 110         


Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala Ser Val Arg Leu Asp 
        115                 120                 125             


Gly Ala Ser Gly His Phe Ala Pro Tyr Glu Phe Pro Ala Val Ala Asp 
    130                 135                 140                 


Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala Lys Ser Cys Gly Ala 
145                 150                 155                 160 


Thr Thr His Val Gly Val Thr Ala Ser Ser Asp Thr Phe Tyr Pro Gly 
                165                 170                 175     


Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val Val Arg Arg Phe Arg 
            180                 185                 190         


Gly Ser Met Glu Glu Trp Arg Val Met Gly Val Met Asn Tyr Glu Met 
        195                 200                 205             


Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser Gln Gly Leu Arg Ala 
    210                 215                 220                 


Gly Met Val Ala Gly Val Ile Val Asn Arg Thr Gln Gln Glu Leu Pro 
225                 230                 235                 240 


Asn Ala Glu Ser Met Pro Gln Val Glu Ser Phe Met Val Lys Ile Val 
                245                 250                 255     


Val Glu Ala Ala Arg Arg Leu Leu 
            260                 


<210> 48
<211> 264
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> uridine phosphorylase

<400> 48
Met His His His His His His Gly Gly Ser Gly Met Ser Glu Ser Asp 
1               5                   10                  15      


Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu Gln Gly Ala Thr Leu 
            20                  25                  30          


Ala Ile Val Pro Gly Asp Pro Ala Arg Val Glu Lys Ile Ala Ala Leu 
        35                  40                  45              


Met Asp Asn Pro Val Lys Leu Gly Gln Trp Arg Glu Phe Ile Thr Trp 
    50                  55                  60                  


Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val Cys Ser Thr Gly Ile 
65                  70                  75                  80  


Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile Leu Ala Gln Leu Gly 
                85                  90                  95      


Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly Ala Ile Gln Gly His 
            100                 105                 110         


Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala Ser Val Arg Leu Asp 
        115                 120                 125             


Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe Pro Ala Val Ala Asp 
    130                 135                 140                 


Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala Lys Ser Cys Gly Ala 
145                 150                 155                 160 


Thr Thr His Val Gly Val Thr Ala Ser Ser Asp Thr Phe Tyr Pro Gly 
                165                 170                 175     


Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val Val Arg Arg Phe Gln 
            180                 185                 190         


Gly Ser Met Glu Glu Trp Arg Glu Met Gly Val Met Asn Tyr Glu Met 
        195                 200                 205             


Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser Gln Gly Leu Arg Ala 
    210                 215                 220                 


Gly Met Val Ala Gly Val Ile Val Asn Arg Thr Gln Gln Glu Leu Pro 
225                 230                 235                 240 


Asn Ala Glu Ser Met Lys Gln Val Glu Ser His Met Val Lys Ile Val 
                245                 250                 255     


Val Glu Ala Ala Arg Arg Leu Leu 
            260                 


<210> 49
<211> 264
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> uridine phosphorylase

<400> 49
Met His His His His His His Gly Gly Ser Gly Met Ser Glu Ser Asp 
1               5                   10                  15      


Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu Gln Gly Ala Thr Leu 
            20                  25                  30          


Ala Ile Val Pro Gly Asp Pro Ala Arg Val Glu Lys Ile Ala Ala Leu 
        35                  40                  45              


Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg Glu Phe Ile Thr Trp 
    50                  55                  60                  


Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val Cys Ser Thr Gly Ile 
65                  70                  75                  80  


Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile Leu Ala Gln Leu Gly 
                85                  90                  95      


Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly Ala Ile Gln Gly His 
            100                 105                 110         


Ile Gly Val Gly Asp Val Leu Val Thr Thr Ala Ser Val Arg Leu Asp 
        115                 120                 125             


Gly Ala Ser Gly His Phe Ala Pro Tyr Glu Phe Pro Ala Val Ala Asp 
    130                 135                 140                 


Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala Lys Ser Cys Gly Ala 
145                 150                 155                 160 


Thr Thr His Val Gly Val Thr Ala Ser Ser Asp Thr Phe Tyr Pro Gly 
                165                 170                 175     


Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val Val Arg Arg Phe Arg 
            180                 185                 190         


Gly Ser Met Glu Glu Trp Arg Glu Met Gly Val Met Asn Tyr Glu Met 
        195                 200                 205             


Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Val Gln Gly Leu Arg Ala 
    210                 215                 220                 


Gly Met Val Ala Gly Val Ile Val Asn Arg Thr Gln Gln Glu Leu Pro 
225                 230                 235                 240 


Asn Ala Glu Asp Met Lys Gln Val Glu Ser His Met Val Lys Ile Val 
                245                 250                 255     


Val Glu Ala Ala Arg Arg Leu Leu 
            260                 


<210> 50
<211> 264
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> uridine phosphorylase

<400> 50
Met His His His His His His Gly Gly Ser Gly Met Ser Glu Ser Asp 
1               5                   10                  15      


Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu Gln Gly Ala Thr Leu 
            20                  25                  30          


Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu Lys Ile Ala Ala Leu 
        35                  40                  45              


Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg Glu Phe Ile Thr Trp 
    50                  55                  60                  


Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val Cys Ser Thr Gly Ile 
65                  70                  75                  80  


Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile Leu Ala Gln Leu Gly 
                85                  90                  95      


Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly Ala Ile Gln Gly His 
            100                 105                 110         


Ile Gly Val Gly Asp Val Leu Val Thr Thr Ala Ser Val Arg Leu Asp 
        115                 120                 125             


Gly Ala Ser Gly His Phe Ala Pro Tyr Glu Phe Pro Ala Val Ala Asp 
    130                 135                 140                 


Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala Lys Ser Ile Gly Ala 
145                 150                 155                 160 


Thr Thr His Val Gly Val Thr Ala Ser Ser Asp Thr Phe Tyr Pro Gly 
                165                 170                 175     


Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val Val Arg Arg Phe Gln 
            180                 185                 190         


Gly Ser Met Glu Glu Trp Arg Glu Met Gly Val Met Asn Tyr Glu Met 
        195                 200                 205             


Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser Gln Gly Leu Arg Ala 
    210                 215                 220                 


Gly Met Val Ala Gly Val Ile Val Asn Arg Thr Gln Gln Glu Leu Pro 
225                 230                 235                 240 


Asn Ala Glu Asp Met Pro Gln Val Glu Ser His Met Val Lys Ile Val 
                245                 250                 255     


Val Glu Ala Ala Arg Arg Leu Leu 
            260                 


<210> 51
<211> 264
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> uridine phosphorylase

<400> 51
Met His His His His His His Gly Gly Ser Gly Met Ser Glu Ser Asp 
1               5                   10                  15      


Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu Gln Gly Ala Thr Leu 
            20                  25                  30          


Ala Ile Val Pro Gly Asp Pro Ala Arg Val Glu Lys Ile Ala Ala Leu 
        35                  40                  45              


Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg Glu Phe Ile Thr Trp 
    50                  55                  60                  


Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val Cys Ser Thr Gly Ile 
65                  70                  75                  80  


Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile Leu Ala Gln Leu Gly 
                85                  90                  95      


Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly Ala Ile Gln Gly His 
            100                 105                 110         


Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala Ser Val Arg Leu Asp 
        115                 120                 125             


Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe Pro Ala Val Ala Asp 
    130                 135                 140                 


Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala Lys Ser Ile Gly Ala 
145                 150                 155                 160 


Thr Thr His Val Gly Val Thr Ala Ser Ser Asp Thr Phe Tyr Pro Gly 
                165                 170                 175     


Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val Val Arg Arg Phe Arg 
            180                 185                 190         


Gly Ser Met Glu Glu Trp Arg Glu Met Gly Val Met Asn Tyr Glu Met 
        195                 200                 205             


Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser Gln Gly Leu Arg Ala 
    210                 215                 220                 


Gly Met Val Ala Gly Val Ile Val Asn Arg Thr Gln Gln Glu Leu Pro 
225                 230                 235                 240 


Glu Ala Glu Asp Met Pro Gln Val Glu Ser His Met Val Lys Ile Val 
                245                 250                 255     


Val Glu Ala Ala Arg Arg Leu Leu 
            260                 


<210> 52
<211> 516
<212> PRT
<213> Corynebacterium glutamicum

<220>
<223> wild-type catalase protein sequence

<400> 52
Met Ser Glu Lys Ser Ala Ala Asp Gln Ile Val Asp Arg Gly Met Arg 
1               5                   10                  15      


Pro Lys Leu Ser Gly Asn Thr Thr Arg His Asn Gly Ala Pro Val Pro 
            20                  25                  30          


Ser Glu Asn Ile Ser Ala Thr Ala Gly Pro Gln Gly Pro Asn Val Leu 
        35                  40                  45              


Asn Asp Ile His Leu Ile Glu Lys Leu Ala His Phe Asn Arg Glu Asn 
    50                  55                  60                  


Val Pro Glu Arg Ile Pro His Ala Lys Gly His Gly Ala Phe Gly Glu 
65                  70                  75                  80  


Leu His Ile Thr Glu Asp Val Ser Glu Tyr Thr Lys Ala Asp Leu Phe 
                85                  90                  95      


Gln Pro Gly Lys Val Thr Pro Leu Ala Val Arg Phe Ser Thr Val Ala 
            100                 105                 110         


Gly Glu Gln Gly Ser Pro Asp Thr Trp Arg Asp Val His Gly Phe Ala 
        115                 120                 125             


Leu Arg Phe Tyr Thr Glu Glu Gly Asn Tyr Asp Ile Val Gly Asn Asn 
    130                 135                 140                 


Thr Pro Thr Phe Phe Leu Arg Asp Gly Met Lys Phe Pro Asp Phe Ile 
145                 150                 155                 160 


His Ser Gln Lys Arg Leu Asn Lys Asn Gly Leu Arg Asp Ala Asp Met 
                165                 170                 175     


Gln Trp Asp Phe Trp Thr Arg Ala Pro Glu Ser Ala His Gln Val Thr 
            180                 185                 190         


Tyr Leu Met Gly Asp Arg Gly Thr Pro Lys Thr Ser Arg His Gln Asp 
        195                 200                 205             


Gly Phe Gly Ser His Thr Phe Gln Trp Ile Asn Ala Glu Gly Lys Pro 
    210                 215                 220                 


Val Trp Val Lys Tyr His Phe Lys Thr Arg Gln Gly Trp Asp Cys Phe 
225                 230                 235                 240 


Thr Asp Ala Glu Ala Ala Lys Val Ala Gly Glu Asn Ala Asp Tyr Gln 
                245                 250                 255     


Arg Glu Asp Leu Tyr Asn Ala Ile Glu Asn Gly Asp Phe Pro Ile Trp 
            260                 265                 270         


Asp Val Lys Val Gln Ile Met Pro Phe Glu Asp Ala Glu Asn Tyr Arg 
        275                 280                 285             


Trp Asn Pro Phe Asp Leu Thr Lys Thr Trp Ser Gln Lys Asp Tyr Pro 
    290                 295                 300                 


Leu Ile Pro Val Gly Tyr Phe Ile Leu Asn Arg Asn Pro Arg Asn Phe 
305                 310                 315                 320 


Phe Ala Gln Ile Glu Gln Ile Ala Leu Asp Pro Gly Asn Ile Val Pro 
                325                 330                 335     


Gly Val Gly Leu Ser Pro Asp Arg Met Leu Gln Ala Arg Ile Phe Ala 
            340                 345                 350         


Tyr Ala Asp Gln Gln Arg Tyr Arg Ile Gly Ala Asn Tyr Arg Asp Leu 
        355                 360                 365             


Pro Val Asn Arg Pro Ile Asn Glu Val Asn Thr Tyr Ser Arg Glu Gly 
    370                 375                 380                 


Ser Met Gln Tyr Ile Phe Asp Ala Glu Gly Glu Pro Ser Tyr Ser Pro 
385                 390                 395                 400 


Asn Arg Tyr Asp Lys Gly Ala Gly Tyr Leu Asp Asn Gly Thr Asp Ser 
                405                 410                 415     


Ser Ser Asn His Thr Ser Tyr Gly Gln Ala Asp Asp Ile Tyr Val Asn 
            420                 425                 430         


Pro Asp Pro His Gly Thr Asp Leu Val Arg Ala Ala Tyr Val Lys His 
        435                 440                 445             


Gln Asp Asp Asp Asp Phe Ile Gln Pro Gly Ile Leu Tyr Arg Glu Val 
    450                 455                 460                 


Leu Asp Glu Gly Glu Lys Glu Arg Leu Ala Asp Asn Ile Ser Asn Ala 
465                 470                 475                 480 


Met Gln Gly Ile Ser Glu Ala Thr Glu Pro Arg Val Tyr Asp Tyr Trp 
                485                 490                 495     


Asn Asn Val Asp Glu Asn Leu Gly Ala Arg Val Lys Glu Leu Tyr Leu 
            500                 505                 510         


Gln Lys Lys Ala 
        515     


<210> 53
<211> 1551
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> catalase DNA sequence 

<400> 53
atgagcgaaa agagcgcggc ggaccaaatt gttgatcgtg gtatgcgtcc gaaactgagc       60

ggcaacacca cccgtcacaa cggtgcgccg gttccgagcg aaaacatcag cgcgaccgcg      120

ggtccgcagg gtccgaacgt gctgaacgac atccacctga ttgagaagct ggcgcacttc      180

aaccgtgaaa acgttccgga gcgtattccg cacgcgaaag gtcacggcgc gtttggtgaa      240

ctgcacatca ccgaagacgt gagcgagtac accaaggcgg acctgttcca accgggtaaa      300

gtgaccccgc tggcggttcg ttttagcacc gttgcgggcg agcaaggtag cccggacacc      360

tggcgtgatg ttcacggttt cgcgctgcgt ttttacaccg aggaaggtaa ctacgatatt      420

gtgggcaaca acaccccgac cttctttctg cgtgacggta tgaagttccc ggattttatc      480

cacagccaga agcgtctgaa caaaaacggc ctgcgtgacg cggatatgca gtgggacttt      540

tggacccgtg cgccggaaag cgcgcaccaa gttacctatc tgatgggtga ccgtggtacc      600

ccgaagacca gccgtcacca ggatggtttc ggcagccaca cctttcaatg gatcaacgcg      660

gagggcaaac cggtgtgggt taagtaccac ttcaaaaccc gtcagggttg ggactgcttt      720

accgatgcgg aagcggcgaa ggtggcgggc gagaacgcgg actaccaacg tgaagatctg      780

tataacgcga tcgagaacgg tgacttcccg atttgggatg tgaaagttca gatcatgccg      840

ttcgaagatg cggagaacta ccgttggaac ccgtttgacc tgaccaagac ctggagccaa      900

aaagattatc cgctgatccc ggttggttac tttattctga accgtaaccc gcgtaacttc      960

tttgcgcaga tcgaacaaat tgcgctggac ccgggcaaca ttgtgccggg tgttggtctg     1020

agcccggacc gtatgctgca ggcgcgtatt ttcgcgtacg cggatcagca acgttatcgt     1080

atcggtgcga actaccgtga cctgccggtt aaccgtccga ttaacgaagt gaacacctat     1140

agccgtgagg gcagcatgca atacatcttt gatgcggagg gtgaaccgag ctacagcccg     1200

aaccgttatg acaagggtgc gggctatctg gacaacggca ccgacagcag cagcaaccac     1260

accagctatg gtcaggcgga cgatatctac gttaacccgg acccgcacgg taccgatctg     1320

gttcgtgcgg cgtatgtgaa gcaccaggac gatgacgatt tcatccaacc gggcattctg     1380

taccgtgagg tgctggacga gggtgaaaaa gagcgtctgg cggataacat tagcaacgcg     1440

atgcaaggta tcagcgaagc gaccgagccg cgtgtttacg actattggaa caacgtggat     1500

gaaaacctgg gcgcgcgtgt gaaagagctg tacctgcaga agaaagcgta a              1551


<210> 54
<211> 1551
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> catalase DNA sequence 

<400> 54
atgtccgaaa aatcagcggc ggatcagatt gtagaccgcg gaatgcgtcc gaaactgtcc       60

ggaaacacca cccgccacaa cggagcgccg gtgccgtccg agaacattag cgcgaccgcg      120

ggcccgcagg gcccgaacgt gctcaatgat atccatctca tcgaaaaact cgcgcacttt      180

aaccgcgaaa acgtgccgga gcgtattcct catgcgaaag gccacggcgc attcggtgaa      240

ctgcatatta ccgaggatgt aagcgaatac accaaagcgg atctgttcca gcctggtaaa      300

gttacccccc tggcagtgcg cttcagcaca gtggcaggtg aacagggcag cccagacacc      360

tggcgcgatg ttcacggctt cgcactgcgc ttctacaccg aagagggcaa ctacgatatt      420

gtaggtaaca acaccccgac cttcttcctg cgtgatggca tgaaattccc cgatttcatt      480

cattcacaga aacgtctcaa caaaaacggt ctgcgcgacg cggatatgca gtgggacttc      540

tggacccgcg cgcctgaatc cgcgcaccag gtaacctacc tgatgggtga tcgcggtacc      600

cctaaaacca gccgccatca ggatggcttc ggcagccaca ccttccagtg gattaacgca      660

gaaggtaaac cggtgtgggt gaaataccat ttcaaaaccc gccagggctg ggactgcttc      720

accgacgcgg aagcggcgaa agtggcgggc gaaaacgcag attaccagcg cgaagatctc      780

tacaacgcaa tcgaaaacgg cgatttcccg atttgggatg ttaaagtgca gattatgcct      840

ttcgaggacg cggaaaacta ccgctggaac ccgttcgacc tgaccaaaac ctggtcccag      900

aaagactacc cgctgattcc ggttggttac ttcattctga accgcaaccc gcgcaacttc      960

ttcgcacaga ttgagcagat cgcgctggac ccgggcaaca ttgtgcctgg cgttggcctg     1020

agcccggatc gcatgctcca ggcgcgtatt ttcgcgtacg cggatcagca gcgttaccgc     1080

attggcgcaa actaccgcga tctgccggta aaccgtccga ttaacgaagt taacacctac     1140

tcacgcgaag gtagcatgca gtacattttc gatgcagagg gcgaacctag ctactcacct     1200

aaccgctacg ataaaggcgc gggctacctg gataacggta ctgacagcag cagcaaccac     1260

accagctacg gccaggcaga cgatatttac gttaacccgg atccgcacgg caccgatctg     1320

gtgcgtgctg catacgttaa acaccaggac gacgatgatt tcattcagcc gggcattcta     1380

taccgcgagg ttctggacga aggcgagaaa gaacgattgg cggataacat tagcaacgct     1440

atgcagggca tttccgaggc aaccgaaccg cgcgtttacg attactggaa caacgtggac     1500

gagaacctcg gcgcacgcgt taaagaactg tacctccaga aaaaagctta a              1551


