                         SEQUENCE LISTING

<110>  OraSure Technologies, Inc.
 
<120>  REAGENTS, METHODS, AND SYSTEMS FOR DETECTING THERAPEUTIC AGENTS 
       TO MONITOR ADHERENCE TO NUCLEOSIDE REVERSE TRANSCRIPTASE 
       INHIBITOR METABOLITES

<130>  018.0091-WO00

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  1

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Gly Ile His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Leu Gly Arg Arg Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  2

Gly Phe Thr Phe Ser Asn Phe Gly 
1               5               


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  3

Ile Ser Ser Gly Ser Ser Thr Ile 
1               5               


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  4

Ala Lys Leu Gly Arg Arg Ala Trp Phe Ala Tyr 
1               5                   10      


<210>  5
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  5

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Leu Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  6
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  6

Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr 
1               5                   10      


<210>  7
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  7

Leu Val Ser 
1           


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  8

Trp Gln Gly Thr His Phe Pro Leu Thr 
1               5                   


<210>  9
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  9

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Ile His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Arg Gly Gly Gly Thr Asp Tyr Asn Ala Ala Phe Met 
    50                  55                  60                  


Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Arg Gly Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Ser Arg Tyr Tyr Asp Phe Ala Leu Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  10

Gly Phe Ser Leu Thr Asn Tyr Gly 
1               5               


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  11

Ile Trp Arg Gly Gly Gly Thr 
1               5           


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial CDR

<400>  12

Ala Ser Arg Tyr Tyr Asp Phe Ala Leu Asp Tyr 
1               5                   10      


<210>  13
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  13

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial CDR

<400>  14

Ser Ser Val Ser Ser Ser Tyr 
1               5           


<210>  15
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial CDR

<400>  15

Ser Thr Ser 
1           


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial CDR

<400>  16

His Gln Tyr His Arg Ser Pro Tyr Thr 
1               5                   


<210>  17
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  17

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Ile His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Arg Gly Gly Gly Thr Asp Tyr Asn Ala Ala Phe Met 
    50                  55                  60                  


Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Arg Gly Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Ser Arg Tyr Tyr Asp Phe Ala Leu Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial CDR

<400>  18

Gly Phe Ser Leu Thr Asn Tyr Gly 
1               5               


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial CDR

<400>  19

Ile Trp Arg Gly Gly Gly Thr 
1               5           


<210>  20
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial CDR

<400>  20

Ala Ser Arg Tyr Tyr Asp Phe Ala Leu Asp Tyr 
1               5                   10      


<210>  21
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  21

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  22
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial CDR

<400>  22

Ser Ser Val Ser Ser Ser Tyr 
1               5           


<210>  23
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial CDR

<400>  23

Ser Thr Ser 
1           


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial CDR

<400>  24

His Gln Tyr His Arg Ser Pro Tyr Thr 
1               5                   


<210>  25
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  25

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Ile His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Arg Gly Gly Gly Thr Asp Tyr Asn Ala Ala Phe Met 
    50                  55                  60                  


Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Arg Gly Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Ser Arg Tyr Tyr Asp Phe Ala Leu Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial CDR

<400>  26

Gly Phe Ser Leu Thr Asn Tyr Gly 
1               5               


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial CDR

<400>  27

Ile Trp Arg Gly Gly Gly Thr 
1               5           


<210>  28
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial CDR

<400>  28

Ala Ser Arg Tyr Tyr Asp Phe Ala Leu Asp Tyr 
1               5                   10      


<210>  29
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  29

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  30
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial CDR

<400>  30

Ser Ser Val Ser Ser Ser Tyr 
1               5           


<210>  31
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial CDR

<400>  31

Ser Thr Ser 
1           


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial CDR

<400>  32

His Gln Tyr His Arg Ser Pro Tyr Thr 
1               5                   


