                         SEQUENCE LISTING

<110>  California Institute of Technology
       Howard Hughes Medical Institute
 
<120>  ENGINEERED OPIOID BIOSENSORS

<130>  30KJ-302436-WO

<150>  63/126,991
<151>  2020-12-17

<150>  63/287,008
<151>  2021-12-07

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Ala Asn Asp Thr Val Val Val Gly Ser Ala Asn Phe Thr Glu Gly Ile 
1               5                   10                  15      


Ile Val Ala Asn Met Val Ala Glu Met Ile Glu Ala His Thr Asp Leu 
            20                  25                  30          


Lys Val Val Arg Lys Leu Asn Leu Gly Gly Glu Asn Val Asn Phe Glu 
        35                  40                  45              


Ala Ile Lys Arg Gly Gly Ala Asn Asn Gly Ile Asp Ile Tyr Val Glu 
    50                  55                  60                  


Tyr Thr Gly His Gly Leu Val Asp Ile Leu Gly Phe Pro Glu Pro Asn 
65                  70                  75                  80  


Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe 
                85                  90                  95      


Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His 
            100                 105                 110         


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
        115                 120                 125             


Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser Lys Asp Pro Asn Glu 
    130                 135                 140                 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
145                 150                 155                 160 


Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met 
                165                 170                 175     


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
            180                 185                 190         


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly 
        195                 200                 205             


Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
    210                 215                 220                 


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
225                 230                 235                 240 


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
                245                 250                 255     


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
            260                 265                 270         


Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys 
        275                 280                 285             


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
    290                 295                 300                 


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe 
305                 310                 315                 320 


Pro Pro Pro Pro Ser Thr Asp Pro Glu Gly Ala Tyr Glu Thr Val Lys 
                325                 330                 335     


Lys Glu Tyr Lys Arg Lys Trp Asn Ile Val Trp Leu Lys Pro Leu Gly 
            340                 345                 350         


Phe Asn Asn Thr Gly Thr Leu Thr Val Lys Asp Glu Leu Ala Lys Gln 
        355                 360                 365             


Tyr Asn Leu Lys Thr Phe Ser Asp Leu Ala Lys Ile Ser Asp Lys Leu 
    370                 375                 380                 


Ile Leu Gly Ala Thr Met Phe Phe Leu Glu Ala Pro Asp Gly Tyr Pro 
385                 390                 395                 400 


Gly Leu Gln Lys Leu Tyr Asn Phe Lys Phe Lys His Thr Lys Ser Met 
                405                 410                 415     


Asp Met Gly Ile Arg Tyr Thr Ala Ile Asp Asn Asn Glu Val Gln Val 
            420                 425                 430         


Ile Asp Ala Trp Ala Thr Asp Gly Leu Leu Val Ser His Lys Leu Lys 
        435                 440                 445             


Ile Leu Glu Asp Asp Lys Ala Phe Phe Pro Pro Tyr Tyr Ala Ala Pro 
    450                 455                 460                 


Ile Ile Arg Gln Asp Val Leu Asp Lys His Pro Glu Leu Lys Asp Val 
465                 470                 475                 480 


Leu Asn Lys Leu Ala Asn Gln Ile Ser Leu Glu Glu Met Gln Lys Leu 
                485                 490                 495     


Asn Tyr Lys Val Asp Gly Glu Gly Gln Asp Pro Ala Lys Val Ala Lys 
            500                 505                 510         


Glu Phe Leu Lys Glu Lys Gly Leu Ile 
        515                 520     


<210>  2
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Ala Asn Asp Thr Val Val Val Gly Ser Ala Asn Phe Thr Glu Gly Ile 
1               5                   10                  15      


Ile Val Ala Asn Met Val Ala Glu Met Ile Glu Ala His Thr Asp Leu 
            20                  25                  30          


Lys Val Val Arg Lys Leu Asn Leu Gly Gly Gly Asn Val Asn Phe Glu 
        35                  40                  45              


Ala Ile Lys Arg Gly Gly Ala Asn Asn Gly Ile Asp Ile Tyr Val Glu 
    50                  55                  60                  


Tyr Thr Gly His Gly Leu Val Asp Ile Leu Gly Phe Pro Glu Pro Asn 
65                  70                  75                  80  


Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe 
                85                  90                  95      


Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His 
            100                 105                 110         


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
        115                 120                 125             


Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser Lys Asp Pro Asn Glu 
    130                 135                 140                 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
145                 150                 155                 160 


Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met 
                165                 170                 175     


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
            180                 185                 190         


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly 
        195                 200                 205             


Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
    210                 215                 220                 


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
225                 230                 235                 240 


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
                245                 250                 255     


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
            260                 265                 270         


Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys 
        275                 280                 285             


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
    290                 295                 300                 


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe 
305                 310                 315                 320 


Pro Pro Pro Ile Ser Thr Asp Pro Glu Gly Ala Tyr Glu Thr Val Lys 
                325                 330                 335     


Lys Glu Tyr Lys Arg Lys Trp Asn Ile Val Trp Leu Lys Pro Leu Gly 
            340                 345                 350         


Phe Asn Asn Thr Gly Thr Leu Thr Val Lys Asp Glu Leu Ala Lys Gln 
        355                 360                 365             


Tyr Asn Leu Lys Thr Phe Ser Asp Leu Ala Lys Ile Ser Asp Lys Leu 
    370                 375                 380                 


Ile Leu Gly Ala Thr Met Phe Phe Leu Glu Ala Pro Asp Gly Tyr Pro 
385                 390                 395                 400 


Gly Leu Gln Lys Leu Tyr Asn Phe Lys Phe Lys His Thr Lys Ser Met 
                405                 410                 415     


Asp Met Gly Ile Arg Tyr Thr Ala Ile Asp Asn Asn Glu Val Gln Val 
            420                 425                 430         


Ile Asp Ala Trp Ala Thr Asp Gly Leu Leu Val Ser His Lys Leu Lys 
        435                 440                 445             


Ile Leu Glu Asp Asp Lys Ala Phe Phe Pro Pro Tyr Tyr Ala Ala Pro 
    450                 455                 460                 


Ile Ile Arg Gln Asp Val Leu Asp Lys His Pro Glu Leu Lys Asp Val 
465                 470                 475                 480 


Leu Asn Lys Leu Ala Asn Gln Ile Ser Gly Glu Glu Met Gln Lys Leu 
                485                 490                 495     


Asn Tyr Lys Val Asp Gly Glu Gly Gln Asp Pro Ala Lys Val Ala Lys 
            500                 505                 510         


Glu Phe Leu Lys Glu Lys Gly Leu Ile 
        515                 520     


<210>  3
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Ala Asn Asp Thr Val Val Val Gly Ser Ile Glu Phe Thr Glu Gly Ile 
1               5                   10                  15      


Ile Val Ala Asn Met Val Ala Glu Met Ile Glu Ala His Thr Asp Leu 
            20                  25                  30          


Lys Val Val Arg Lys Leu Asn Leu Gly Gly Glu Asn Val Asn Phe Glu 
        35                  40                  45              


Ala Ile Lys Arg Gly Gly Ala Asn Asn Gly Ile Asp Ile Tyr Val Glu 
    50                  55                  60                  


Tyr Thr Gly His Gly Leu Val Asp Ile Leu Gly Phe Pro Glu Pro Asn 
65                  70                  75                  80  


Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe 
                85                  90                  95      


Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His 
            100                 105                 110         


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
        115                 120                 125             


Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser Lys Asp Pro Asn Glu 
    130                 135                 140                 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
145                 150                 155                 160 


Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met 
                165                 170                 175     


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
            180                 185                 190         


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly 
        195                 200                 205             


Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
    210                 215                 220                 


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
225                 230                 235                 240 


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
                245                 250                 255     


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
            260                 265                 270         


Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys 
        275                 280                 285             


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
    290                 295                 300                 


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe 
305                 310                 315                 320 


Pro Pro Pro Ser Ser Thr Asp Pro Glu Gly Ala Tyr Glu Thr Val Lys 
                325                 330                 335     


Lys Glu Tyr Lys Arg Lys Trp Asn Ile Val Trp Leu Lys Pro Leu Gly 
            340                 345                 350         


Phe Asn Asn Thr Tyr Thr Leu Thr Val Lys Asp Glu Leu Ala Lys Gln 
        355                 360                 365             


Tyr Asn Leu Lys Thr Phe Ser Asp Leu Ala Lys Ile Ser Asp Lys Leu 
    370                 375                 380                 


Ile Leu Gly Ala Thr Met Phe Phe Leu Glu Gly Pro Asp Gly Tyr Pro 
385                 390                 395                 400 


Gly Leu Gln Lys Leu Tyr Asn Phe Lys Phe Lys His Thr Lys Ser Met 
                405                 410                 415     


Asp Met Gly Ile Arg Tyr Thr Ala Ile Asp Asn Asn Glu Val Gln Val 
            420                 425                 430         


Ile Asp Ala Ala Ala Thr Asp Gly Leu Leu Val Ser His Lys Leu Lys 
        435                 440                 445             


Ile Leu Glu Asp Asp Lys Ala Phe Phe Pro Pro Tyr Tyr Ala Ala Pro 
    450                 455                 460                 


Ile Ile Arg Gln Asp Val Leu Asp Lys His Pro Glu Leu Lys Asp Val 
465                 470                 475                 480 


Leu Asn Lys Leu Ala Asn Gln Ile Ser Leu Glu Glu Met Gln Lys Leu 
                485                 490                 495     


Asn Tyr Lys Val Asp Gly Glu Gly Gln Asp Pro Ala Lys Val Ala Lys 
            500                 505                 510         


Glu Phe Leu Lys Glu Lys Gly Leu Ile 
        515                 520     


<210>  4
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Ala Asn Asp Thr Val Val Val Gly Ser Ile Val Phe Thr Glu Gly Ile 
1               5                   10                  15      


Ile Val Ala Asn Met Val Ala Glu Met Ile Glu Ala His Thr Asp Leu 
            20                  25                  30          


Lys Val Val Arg Lys Leu Asn Leu Gly Gly Glu Asn Val Asn Phe Glu 
        35                  40                  45              


Ala Ile Lys Arg Gly Gly Ala Asn Asn Gly Ile Asp Ile Tyr Val Glu 
    50                  55                  60                  


Tyr Thr Gly His Gly Leu Val Asp Ile Leu Gly Phe Pro Glu Pro Asn 
65                  70                  75                  80  


Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe 
                85                  90                  95      


Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His 
            100                 105                 110         


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
        115                 120                 125             


Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser Lys Asp Pro Asn Glu 
    130                 135                 140                 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
145                 150                 155                 160 


Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met 
                165                 170                 175     


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
            180                 185                 190         


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly 
        195                 200                 205             


Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
    210                 215                 220                 


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
225                 230                 235                 240 


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
                245                 250                 255     


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
            260                 265                 270         


Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys 
        275                 280                 285             


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
    290                 295                 300                 


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe 
305                 310                 315                 320 


Pro Pro Pro Ser Ser Thr Asp Pro Glu Gly Ala Tyr Glu Thr Val Lys 
                325                 330                 335     


Lys Glu Tyr Lys Arg Lys Trp Asn Ile Val Trp Leu Lys Pro Leu Gly 
            340                 345                 350         


Phe Asn Asn Thr Tyr Thr Leu Thr Val Lys Asp Glu Leu Ala Lys Gln 
        355                 360                 365             


Tyr Asn Leu Lys Thr Phe Ser Asp Leu Ala Lys Ile Ser Asp Lys Leu 
    370                 375                 380                 


Ile Leu Gly Ala Thr Met Phe Phe Leu Glu Gly Pro Asp Gly Tyr Pro 
385                 390                 395                 400 


Gly Leu Gln Lys Leu Tyr Asn Phe Lys Phe Lys His Thr Lys Ser Met 
                405                 410                 415     


Asp Met Gly Ile Arg Tyr Thr Ala Ile Asp Asn Asn Glu Val Gln Val 
            420                 425                 430         


Ile Asp Ala Phe Ala Thr Asp Gly Leu Leu Val Ser His Lys Leu Lys 
        435                 440                 445             


Ile Leu Glu Asp Asp Lys Ala Phe Phe Pro Pro Tyr Tyr Ala Ala Pro 
    450                 455                 460                 


Ile Ile Arg Gln Asp Val Leu Asp Lys His Pro Glu Leu Lys Asp Val 
465                 470                 475                 480 


Leu Asn Lys Leu Ala Asn Gln Ile Ser Ala Glu Glu Met Gln Lys Leu 
                485                 490                 495     


Asn Tyr Lys Val Asp Gly Glu Gly Gln Asp Pro Ala Lys Val Ala Lys 
            500                 505                 510         


Glu Phe Leu Lys Glu Lys Gly Leu Ile 
        515                 520     


<210>  5
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Ala Asn Asp Thr Val Val Val Gly Ser Ile Ile Phe Thr Glu Thr Ile 
1               5                   10                  15      


Ile Val Ala Asn Met Val Ala Glu Met Ile Glu Ala His Thr Asp Leu 
            20                  25                  30          


Lys Val Val Arg Lys Leu Asn Leu Gly Gly Val Asn Val Asn Phe Glu 
        35                  40                  45              


Ala Ile Lys Arg Gly Gly Ala Asn Asn Gly Ile Asp Ile Tyr Val Glu 
    50                  55                  60                  


Tyr Thr Gly His Gly Leu Val Asp Ile Leu Gly Phe Pro Glu Pro Asn 
65                  70                  75                  80  


Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe 
                85                  90                  95      


Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His 
            100                 105                 110         


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
        115                 120                 125             


Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser Lys Asp Pro Asn Glu 
    130                 135                 140                 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
145                 150                 155                 160 


Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met 
                165                 170                 175     


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
            180                 185                 190         


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly 
        195                 200                 205             


Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
    210                 215                 220                 


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
225                 230                 235                 240 


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
                245                 250                 255     


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
            260                 265                 270         


Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys 
        275                 280                 285             


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
    290                 295                 300                 


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe 
305                 310                 315                 320 


Pro Pro Pro Ala Thr Thr Asp Pro Glu Gly Ala Tyr Glu Thr Val Lys 
                325                 330                 335     


Lys Glu Tyr Lys Arg Lys Trp Asn Ile Val Trp Leu Lys Pro Leu Gly 
            340                 345                 350         


Phe Asn Asn Thr Tyr Thr Leu Thr Val Lys Asp Glu Leu Ala Lys Gln 
        355                 360                 365             


Tyr Asn Leu Lys Thr Phe Ser Asp Leu Ala Lys Ile Ser Asp Lys Leu 
    370                 375                 380                 


Ile Leu Gly Ala Thr Met Phe Phe Leu Glu Gly Pro Asp Gly Tyr Pro 
385                 390                 395                 400 


Gly Leu Gln Lys Leu Tyr Asn Phe Lys Phe Lys His Thr Lys Ser Met 
                405                 410                 415     


Asp Met Gly Ile Arg Tyr Thr Ala Ile Asp Asn Asn Glu Val Gln Val 
            420                 425                 430         


Ile Asp Ala Trp Ala Thr Asp Gly Leu Leu Val Ser His Lys Leu Lys 
        435                 440                 445             


Ile Leu Glu Asp Asp Lys Trp Phe Phe Pro Pro Tyr Tyr Ala Ala Pro 
    450                 455                 460                 


Ile Ile Arg Gln Asp Val Leu Asp Lys His Pro Glu Leu Lys Asp Val 
465                 470                 475                 480 


Leu Asn Lys Leu Ala Asn Gln Ile Ser Leu Glu Glu Met Gln Lys Leu 
                485                 490                 495     


Asn Tyr Lys Val Asp Gly Glu Gly Gln Asp Pro Ala Lys Val Ala Lys 
            500                 505                 510         


Glu Phe Leu Lys Glu Lys Gly Leu Ile 
        515                 520     


<210>  6
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Ala Asn Asp Thr Val Val Val Gly Ser Ile Glu Phe Thr Glu Gly Ile 
1               5                   10                  15      


Ile Val Ala Asn Met Val Ala Glu Met Ile Glu Ala His Thr Asp Leu 
            20                  25                  30          


Lys Val Val Arg Lys Leu Asn Leu Gly Gly Val Asn Val Asn Phe Glu 
        35                  40                  45              


Ala Ile Lys Arg Gly Gly Ala Asn Asn Gly Ile Asp Ile Tyr Val Glu 
    50                  55                  60                  


Tyr Thr Gly Thr Gly Leu Val Asp Ile Leu Gly Phe Pro Glu Pro Asn 
65                  70                  75                  80  


Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe 
                85                  90                  95      


Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His 
            100                 105                 110         


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
        115                 120                 125             


Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser Lys Asp Pro Asn Glu 
    130                 135                 140                 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
145                 150                 155                 160 


Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met 
                165                 170                 175     


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
            180                 185                 190         


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly 
        195                 200                 205             


Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
    210                 215                 220                 


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
225                 230                 235                 240 


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
                245                 250                 255     


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
            260                 265                 270         


Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys 
        275                 280                 285             


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
    290                 295                 300                 


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe 
305                 310                 315                 320 


Pro Pro Pro Pro Met Thr Asp Pro Glu Gly Ala Tyr Glu Thr Val Lys 
                325                 330                 335     


Lys Glu Tyr Lys Arg Lys Trp Asn Ile Val Trp Leu Lys Pro Leu Gly 
            340                 345                 350         


Phe Asn Asn Thr Tyr Thr Leu Thr Val Lys Asp Glu Leu Ala Lys Gln 
        355                 360                 365             


Tyr Asn Leu Lys Thr Phe Ser Asp Leu Ala Lys Ile Ser Asp Lys Leu 
    370                 375                 380                 


Ile Leu Gly Ala Thr Met Phe Phe Leu Glu Gly Pro Asp Gly Tyr Pro 
385                 390                 395                 400 


Gly Leu Gln Lys Leu Tyr Asn Phe Lys Phe Lys His Thr Lys Ser Met 
                405                 410                 415     


Asp Met Gly Ile Arg Tyr Thr Ala Ile Asp Asn Asn Glu Val Gln Val 
            420                 425                 430         


Ile Asp Ala Trp Ala Thr Asp Gly Leu Leu Val Ser His Lys Leu Lys 
        435                 440                 445             


Ile Leu Glu Asp Asp Lys Ala Phe Phe Pro Pro Tyr Tyr Ala Ala Pro 
    450                 455                 460                 


Ile Ile Arg Gln Asp Val Leu Asp Lys His Pro Glu Leu Lys Asp Val 
465                 470                 475                 480 


Leu Asn Lys Leu Ala Asn Gln Ile Ser Leu Glu Glu Met Gln Lys Leu 
                485                 490                 495     


Asn Tyr Lys Val Asp Gly Glu Gly Gln Asp Pro Ala Lys Val Ala Lys 
            500                 505                 510         


Glu Phe Leu Lys Glu Lys Gly Leu Ile 
        515                 520     


<210>  7
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Ala Asn Asp Thr Val Val Val Gly Ser Ile Glu Phe Thr Glu Gly Ile 
1               5                   10                  15      


Ile Val Ala Asn Met Val Ala Glu Met Ile Glu Ala His Thr Asp Leu 
            20                  25                  30          


Lys Val Val Arg Lys Leu Asn Leu Gly Gly Val Asn Val Asn Phe Glu 
        35                  40                  45              


Ala Ile Lys Arg Gly Gly Ala Asn Asn Gly Ile Asp Ile Tyr Val Glu 
    50                  55                  60                  


Tyr Thr Gly Thr Gly Leu Val Asp Ile Leu Gly Phe Pro Glu Pro Asn 
65                  70                  75                  80  


Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe 
                85                  90                  95      


Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His 
            100                 105                 110         


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
        115                 120                 125             


Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser Lys Asp Pro Asn Glu 
    130                 135                 140                 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
145                 150                 155                 160 


Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met 
                165                 170                 175     


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
            180                 185                 190         


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly 
        195                 200                 205             


Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
    210                 215                 220                 


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
225                 230                 235                 240 


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
                245                 250                 255     


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
            260                 265                 270         


Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys 
        275                 280                 285             


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
    290                 295                 300                 


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe 
305                 310                 315                 320 


Pro Pro Pro Pro Val Thr Asp Pro Glu Gly Ala Tyr Glu Thr Val Lys 
                325                 330                 335     


Lys Glu Tyr Lys Arg Lys Trp Asn Ile Val Trp Leu Lys Pro Leu Gly 
            340                 345                 350         


Phe Asn Asn Thr Tyr Thr Leu Thr Val Lys Asp Glu Leu Ala Lys Gln 
        355                 360                 365             


Tyr Asn Leu Lys Thr Phe Ser Asp Leu Ala Lys Ile Ser Asp Lys Leu 
    370                 375                 380                 


Ile Leu Gly Ala Thr Met Phe Phe Leu Glu Gly Pro Asp Gly Tyr Pro 
385                 390                 395                 400 


Gly Leu Gln Lys Leu Tyr Asn Phe Lys Phe Lys His Thr Lys Ser Met 
                405                 410                 415     


Asp Met Gly Ile Arg Tyr Thr Ala Ile Asp Asn Asn Glu Val Gln Val 
            420                 425                 430         


Ile Asp Ala Trp Ala Thr Asp Gly Leu Leu Val Ser His Lys Leu Lys 
        435                 440                 445             


Ile Leu Glu Asp Asp Lys Ala Phe Phe Pro Pro Tyr Tyr Ala Ala Pro 
    450                 455                 460                 


Ile Ile Arg Gln Asp Val Leu Asp Lys His Pro Glu Leu Lys Asp Val 
465                 470                 475                 480 


Leu Asn Lys Leu Ala Asn Gln Ile Ser Leu Glu Glu Met Gln Lys Leu 
                485                 490                 495     


Asn Tyr Lys Val Asp Gly Glu Gly Gln Asp Pro Ala Lys Val Ala Lys 
            500                 505                 510         


Glu Phe Leu Lys Glu Lys Gly Leu Ile 
        515                 520     


<210>  8
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Ala Asn Asp Thr Val Val Val Gly Ser Ile Glu Phe Thr Glu Gly Ile 
1               5                   10                  15      


Ile Val Ala Asn Met Val Ala Glu Met Ile Glu Ala His Thr Asp Leu 
            20                  25                  30          


Lys Val Val Arg Lys Leu Asn Leu Gly Gly Val Asn Val Asn Phe Glu 
        35                  40                  45              


Ala Ile Lys Arg Gly Gly Ala Asn Asn Gly Ile Asp Ile Tyr Val Glu 
    50                  55                  60                  


Tyr Thr Gly Thr Gly Leu Val Asp Ile Leu Gly Phe Pro Glu Pro Asn 
65                  70                  75                  80  


Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe 
                85                  90                  95      


Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His 
            100                 105                 110         


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
        115                 120                 125             


Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser Lys Asp Pro Asn Glu 
    130                 135                 140                 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
145                 150                 155                 160 


Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met 
                165                 170                 175     


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
            180                 185                 190         


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly 
        195                 200                 205             


Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
    210                 215                 220                 


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
225                 230                 235                 240 


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
                245                 250                 255     


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
            260                 265                 270         


Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys 
        275                 280                 285             


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
    290                 295                 300                 


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe 
305                 310                 315                 320 


Pro Pro Pro Pro Arg Thr Asp Pro Glu Gly Ala Tyr Glu Thr Val Lys 
                325                 330                 335     


Lys Glu Tyr Lys Arg Lys Trp Asn Ile Val Trp Leu Lys Pro Leu Gly 
            340                 345                 350         


Phe Asn Asn Thr Tyr Thr Leu Thr Val Lys Asp Glu Leu Ala Lys Gln 
        355                 360                 365             


Tyr Asn Leu Lys Thr Phe Ser Asp Leu Ala Lys Ile Ser Asp Lys Leu 
    370                 375                 380                 


Ile Leu Gly Ala Thr Met Phe Phe Leu Glu Gly Pro Asp Gly Tyr Pro 
385                 390                 395                 400 


Gly Leu Gln Lys Leu Tyr Asn Phe Lys Phe Lys His Thr Lys Ser Met 
                405                 410                 415     


Asp Met Gly Ile Arg Tyr Thr Ala Ile Asp Asn Asn Glu Val Gln Val 
            420                 425                 430         


Ile Asp Ala Trp Ala Thr Asp Gly Leu Leu Val Ser His Lys Leu Lys 
        435                 440                 445             


Ile Leu Glu Asp Asp Lys Ala Phe Phe Pro Pro Tyr Tyr Ala Ala Pro 
    450                 455                 460                 


Ile Ile Arg Gln Asp Val Leu Asp Lys His Pro Glu Leu Lys Asp Val 
465                 470                 475                 480 


Leu Asn Lys Leu Ala Asn Gln Ile Ser Leu Glu Glu Met Gln Lys Leu 
                485                 490                 495     


Asn Tyr Lys Val Asp Gly Glu Gly Gln Asp Pro Ala Lys Val Ala Lys 
            500                 505                 510         


Glu Phe Leu Lys Glu Lys Gly Leu Ile 
        515                 520     


<210>  9
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Ala Asn Asp Thr Val Val Val Gly Ser Ile Glu Phe Thr Glu Gly Ile 
1               5                   10                  15      


Ile Val Ala Asn Met Val Ala Glu Met Ile Glu Ala His Thr Asp Leu 
            20                  25                  30          


Lys Val Val Arg Lys Leu Asn Leu Gly Gly Glu Asn Val Asn Phe Glu 
        35                  40                  45              


Ala Ile Lys Arg Gly Gly Ala Asn Asn Gly Ile Asp Ile Tyr Val Glu 
    50                  55                  60                  


Tyr Thr Gly His Gly Leu Val Asp Ile Leu Gly Phe Pro Glu Pro Asn 
65                  70                  75                  80  


Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe 
                85                  90                  95      


Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His 
            100                 105                 110         


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
        115                 120                 125             


Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser Lys Asp Pro Asn Glu 
    130                 135                 140                 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
145                 150                 155                 160 


Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met 
                165                 170                 175     


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
            180                 185                 190         


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly 
        195                 200                 205             


Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
    210                 215                 220                 


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
225                 230                 235                 240 


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
                245                 250                 255     


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
            260                 265                 270         


Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys 
        275                 280                 285             


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
    290                 295                 300                 


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe 
305                 310                 315                 320 


Pro Pro Pro Ser Ser Thr Asp Pro Glu Gly Ala Tyr Glu Thr Val Lys 
                325                 330                 335     


Lys Glu Tyr Lys Arg Lys Trp Asn Ile Val Trp Leu Lys Pro Leu Gly 
            340                 345                 350         


Phe Asn Asn Thr Tyr Thr Leu Thr Val Lys Asp Glu Leu Ala Lys Gln 
        355                 360                 365             


Tyr Asn Leu Lys Thr Phe Ser Asp Leu Ala Lys Ile Ser Asp Lys Leu 
    370                 375                 380                 


Ile Leu Gly Ala Thr Met Phe Phe Leu Glu Gly Pro Asp Gly Tyr Pro 
385                 390                 395                 400 


Gly Leu Gln Lys Leu Tyr Asn Phe Lys Phe Lys His Thr Lys Ser Met 
                405                 410                 415     


Asp Met Gly Ile Arg Tyr Thr Ala Ile Asp Asn Asn Glu Val Gln Val 
            420                 425                 430         


Ile Asp Ala Thr Ala Thr Asp Gly Leu Leu Val Ser His Lys Leu Lys 
        435                 440                 445             


Ile Leu Glu Asp Asp Lys Ala Phe Phe Pro Pro Tyr Tyr Ala Ala Pro 
    450                 455                 460                 


Ile Ile Arg Gln Asp Val Leu Asp Lys His Pro Glu Leu Lys Asp Val 
465                 470                 475                 480 


Leu Asn Lys Leu Ala Asn Gln Ile Ser Leu Glu Glu Met Gln Lys Leu 
                485                 490                 495     


Asn Tyr Lys Val Asp Gly Glu Gly Gln Asp Pro Ala Lys Val Ala Lys 
            500                 505                 510         


Glu Phe Leu Lys Glu Lys Gly Leu Ile 
        515                 520     


<210>  10
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Ala Asn Asp Thr Val Val Val Gly Ser Ile Glu Phe Thr Glu Gly Ile 
1               5                   10                  15      


Ile Val Ala Asn Met Val Ala Glu Met Ile Glu Ala His Thr Asp Leu 
            20                  25                  30          


Lys Val Val Arg Lys Leu Asn Leu Gly Gly Glu Asn Val Asn Phe Glu 
        35                  40                  45              


Ala Ile Lys Arg Gly Gly Ala Asn Asn Gly Ile Asp Ile Tyr Val Glu 
    50                  55                  60                  


Tyr Thr Gly His Gly Leu Val Asp Ile Leu Gly Phe Pro Glu Pro Asn 
65                  70                  75                  80  


Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe 
                85                  90                  95      


Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His 
            100                 105                 110         


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
        115                 120                 125             


Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser Lys Asp Pro Asn Glu 
    130                 135                 140                 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
145                 150                 155                 160 


Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met 
                165                 170                 175     


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
            180                 185                 190         


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly 
        195                 200                 205             


Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
    210                 215                 220                 


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
225                 230                 235                 240 


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
                245                 250                 255     


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
            260                 265                 270         


Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys 
        275                 280                 285             


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
    290                 295                 300                 


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe 
305                 310                 315                 320 


Pro Pro Pro Ser Ser Thr Asp Pro Glu Gly Ala Tyr Glu Thr Val Lys 
                325                 330                 335     


Lys Glu Tyr Lys Arg Lys Trp Asn Ile Val Trp Leu Lys Pro Leu Gly 
            340                 345                 350         


Phe Asn Asn Thr Tyr Thr Leu Thr Val Lys Asp Glu Leu Ala Lys Gln 
        355                 360                 365             


Tyr Asn Leu Lys Thr Phe Ser Asp Leu Ala Lys Ile Ser Asp Lys Leu 
    370                 375                 380                 


Ile Leu Gly Ala Thr Met Phe Phe Leu Glu Gly Pro Asp Gly Tyr Pro 
385                 390                 395                 400 


Gly Leu Gln Lys Leu Tyr Asn Phe Lys Phe Lys His Thr Lys Ser Met 
                405                 410                 415     


Asp Met Gly Ile Arg Tyr Thr Ala Ile Asp Asn Asn Glu Val Gln Val 
            420                 425                 430         


Ile Asp Ala Cys Ala Thr Asp Gly Leu Leu Val Ser His Lys Leu Lys 
        435                 440                 445             


Ile Leu Glu Asp Asp Lys Ala Phe Phe Pro Pro Tyr Tyr Ala Ala Pro 
    450                 455                 460                 


Ile Ile Arg Gln Asp Val Leu Asp Lys His Pro Glu Leu Lys Asp Val 
465                 470                 475                 480 


Leu Asn Lys Leu Ala Asn Gln Ile Ser Leu Glu Glu Met Gln Lys Leu 
                485                 490                 495     


Asn Tyr Lys Val Asp Gly Glu Gly Gln Asp Pro Ala Lys Val Ala Lys 
            500                 505                 510         


Glu Phe Leu Lys Glu Lys Gly Leu Ile 
        515                 520     


<210>  11
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Ala Asn Asp Thr Val Val Val Gly Ser Ile Glu Phe Thr Glu Gly Ile 
1               5                   10                  15      


Ile Val Ala Asn Met Val Ala Glu Met Ile Glu Ala His Thr Asp Leu 
            20                  25                  30          


Lys Val Val Arg Lys Leu Asn Leu Gly Gly Val Asn Val Asn Phe Glu 
        35                  40                  45              


Ala Ile Lys Arg Gly Gly Ala Asn Asn Gly Ile Asp Ile Tyr Val Glu 
    50                  55                  60                  


Tyr Thr Gly Thr Gly Leu Val Asp Ile Leu Gly Phe Pro Glu Pro Asn 
65                  70                  75                  80  


Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe 
                85                  90                  95      


Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His 
            100                 105                 110         


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
        115                 120                 125             


Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser Lys Asp Pro Asn Glu 
    130                 135                 140                 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
145                 150                 155                 160 


Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met 
                165                 170                 175     


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
            180                 185                 190         


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly 
        195                 200                 205             


Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
    210                 215                 220                 


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
225                 230                 235                 240 


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
                245                 250                 255     


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
            260                 265                 270         


Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys 
        275                 280                 285             


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
    290                 295                 300                 


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe 
305                 310                 315                 320 


Pro Pro Pro Ser Ser Thr Asp Pro Glu Gly Ala Tyr Glu Thr Val Lys 
                325                 330                 335     


Lys Glu Tyr Lys Arg Lys Trp Asn Ile Val Trp Leu Lys Pro Leu Gly 
            340                 345                 350         


Phe Asn Asn Thr Tyr Thr Leu Thr Val Lys Asp Glu Leu Ala Lys Gln 
        355                 360                 365             


Tyr Asn Leu Lys Thr Phe Ser Asp Leu Ala Lys Ile Ser Asp Lys Leu 
    370                 375                 380                 


Ile Leu Gly Ala Thr Met Phe Phe Leu Glu Gly Pro Asp Gly Tyr Pro 
385                 390                 395                 400 


Gly Leu Gln Lys Leu Tyr Asn Phe Lys Phe Lys His Thr Lys Ser Met 
                405                 410                 415     


Asp Met Gly Ile Arg Tyr Thr Ala Ile Asp Asn Asn Glu Val Gln Val 
            420                 425                 430         


Ile Asp Ala Trp Ala Thr Asp Gly Leu Leu Val Ser His Lys Leu Lys 
        435                 440                 445             


Ile Leu Glu Asp Asp Lys Ala Phe Phe Pro Pro Tyr Tyr Ala Ala Pro 
    450                 455                 460                 


Ile Ile Arg Gln Asp Val Leu Asp Lys His Pro Glu Leu Lys Asp Val 
465                 470                 475                 480 


Leu Asn Lys Leu Ala Asn Gln Ile Ser Leu Glu Glu Met Gln Lys Leu 
                485                 490                 495     


Asn Tyr Lys Val Asp Gly Glu Gly Gln Asp Pro Ala Lys Val Ala Lys 
            500                 505                 510         


Glu Phe Leu Lys Glu Lys Gly Leu Ile 
        515                 520     


<210>  12
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Ala Asn Asp Thr Val Val Val Gly Ser Ile Glu Phe Thr Glu Gly Ile 
1               5                   10                  15      


Ile Val Ala Asn Met Val Ala Glu Met Ile Glu Ala His Thr Asp Leu 
            20                  25                  30          


Lys Val Val Arg Lys Leu Asn Leu Gly Gly Val Asn Val Asn Phe Glu 
        35                  40                  45              


Ala Ile Lys Arg Gly Gly Ala Asn Asn Gly Ile Asp Ile Tyr Val Glu 
    50                  55                  60                  


Tyr Thr Gly Thr Gly Leu Val Asp Ile Leu Gly Phe Pro Glu Pro Asn 
65                  70                  75                  80  


Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe 
                85                  90                  95      


Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His 
            100                 105                 110         


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
        115                 120                 125             


Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser Lys Asp Pro Asn Glu 
    130                 135                 140                 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
145                 150                 155                 160 


Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met 
                165                 170                 175     


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
            180                 185                 190         


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly 
        195                 200                 205             


Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
    210                 215                 220                 


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
225                 230                 235                 240 


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
                245                 250                 255     


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
            260                 265                 270         


Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys 
        275                 280                 285             


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
    290                 295                 300                 


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe 
305                 310                 315                 320 


Pro Pro Pro Ser Ser Thr Asp Pro Glu Gly Ala Tyr Glu Thr Val Lys 
                325                 330                 335     


Lys Glu Tyr Lys Arg Lys Trp Asn Ile Val Trp Leu Lys Pro Leu Gly 
            340                 345                 350         


Phe Asn Asn Thr Tyr Thr Leu Thr Val Lys Asp Glu Leu Ala Lys Gln 
        355                 360                 365             


Tyr Asn Leu Lys Thr Phe Ser Asp Leu Ala Lys Ile Ser Asp Lys Leu 
    370                 375                 380                 


Ile Leu Gly Ala Thr Met Phe Phe Leu Glu Arg Pro Asp Gly Tyr Pro 
385                 390                 395                 400 


Gly Leu Gln Lys Leu Tyr Asn Phe Lys Phe Lys His Thr Lys Ser Met 
                405                 410                 415     


Asp Met Gly Ile Arg Tyr Thr Ala Ile Asp Asn Asn Glu Val Gln Val 
            420                 425                 430         


Ile Asp Ala Trp Ala Thr Asp Gly Leu Leu Val Ser His Lys Leu Lys 
        435                 440                 445             


Ile Leu Glu Asp Asp Lys Ala Phe Phe Pro Pro Tyr Tyr Ala Ala Pro 
    450                 455                 460                 


Ile Ile Arg Gln Asp Val Leu Asp Lys His Pro Glu Leu Lys Asp Val 
465                 470                 475                 480 


Leu Asn Lys Leu Ala Asn Gln Ile Ser Leu Glu Glu Met Gln Lys Leu 
                485                 490                 495     


Asn Tyr Lys Val Asp Gly Glu Gly Gln Asp Pro Ala Lys Val Ala Lys 
            500                 505                 510         


Glu Phe Leu Lys Glu Lys Gly Leu Ile 
        515                 520     


<210>  13
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Ala Asn Asp Thr Val Val Val Gly Ser Ile Asn Phe Thr Glu Gly Ile 
1               5                   10                  15      


Ile Val Ala Asn Met Val Ala Glu Met Ile Glu Ala His Thr Asp Leu 
            20                  25                  30          


Lys Val Val Arg Lys Leu Asn Leu Gly Gly Glu Asn Val Asn Phe Glu 
        35                  40                  45              


Ala Ile Lys Arg Gly Gly Ala Asn Asn Gly Ile Asp Ile Tyr Val Glu 
    50                  55                  60                  


Tyr Thr Gly His Gly Leu Val Asp Ile Leu Gly Phe Pro Glu Pro Asn 
65                  70                  75                  80  


Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe 
                85                  90                  95      


Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His 
            100                 105                 110         


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
        115                 120                 125             


Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser Lys Asp Pro Asn Glu 
    130                 135                 140                 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
145                 150                 155                 160 


Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met 
                165                 170                 175     


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
            180                 185                 190         


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly 
        195                 200                 205             


Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
    210                 215                 220                 


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
225                 230                 235                 240 


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
                245                 250                 255     


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
            260                 265                 270         


Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys 
        275                 280                 285             


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
    290                 295                 300                 


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe 
305                 310                 315                 320 


Pro Pro Pro Pro Ser Thr Asp Pro Glu Gly Ala Tyr Glu Thr Val Lys 
                325                 330                 335     


Lys Glu Tyr Lys Arg Lys Trp Asn Ile Val Trp Leu Lys Pro Leu Gly 
            340                 345                 350         


Phe Asn Asn Thr Gly Thr Leu Thr Val Lys Asp Glu Leu Ala Lys Gln 
        355                 360                 365             


Tyr Asn Leu Lys Thr Phe Ser Asp Leu Ala Lys Ile Ser Asp Lys Leu 
    370                 375                 380                 


Ile Leu Gly Ala Thr Met Phe Phe Leu Glu Ala Pro Asp Gly Tyr Pro 
385                 390                 395                 400 


Gly Leu Gln Lys Leu Tyr Asn Phe Lys Phe Lys His Thr Lys Ser Met 
                405                 410                 415     


Asp Met Gly Ile Arg Tyr Thr Ala Ile Asp Asn Asn Glu Val Gln Val 
            420                 425                 430         


Ile Asp Ala Trp Ala Thr Asp Gly Leu Leu Val Ser His Lys Leu Lys 
        435                 440                 445             


Ile Leu Glu Asp Asp Lys Ala Phe Phe Pro Pro Tyr Tyr Ala Ala Pro 
    450                 455                 460                 


Ile Ile Arg Gln Asp Val Leu Asp Lys His Pro Glu Leu Lys Asp Val 
465                 470                 475                 480 


Leu Asn Lys Leu Ala Asn Gln Ile Ser Leu Glu Glu Met Gln Lys Leu 
                485                 490                 495     


Asn Tyr Lys Val Asp Gly Glu Gly Gln Asp Pro Ala Lys Val Ala Lys 
            500                 505                 510         


Glu Phe Leu Lys Glu Lys Gly Leu Ile 
        515                 520     


<210>  14
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Ala Asn Asp Thr Val Val Val Gly Ser Ile Pro Phe Thr Glu Gly Ile 
1               5                   10                  15      


Ile Val Ala Asn Met Val Ala Glu Met Ile Glu Ala His Thr Asp Leu 
            20                  25                  30          


Lys Val Val Arg Lys Leu Asn Leu Gly Gly Ile Asn Val Asn Phe Glu 
        35                  40                  45              


Ala Ile Lys Arg Gly Gly Ala Asn Asn Gly Ile Asp Ile Tyr Val Glu 
    50                  55                  60                  


Tyr Thr Gly His Gly Leu Val Asp Ile Leu Gly Phe Pro Glu Pro Asn 
65                  70                  75                  80  


Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe 
                85                  90                  95      


Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His 
            100                 105                 110         


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
        115                 120                 125             


Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser Lys Asp Pro Asn Glu 
    130                 135                 140                 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
145                 150                 155                 160 


Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met 
                165                 170                 175     


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
            180                 185                 190         


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly 
        195                 200                 205             


Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
    210                 215                 220                 


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
225                 230                 235                 240 


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
                245                 250                 255     


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
            260                 265                 270         


Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys 
        275                 280                 285             


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
    290                 295                 300                 


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe 
305                 310                 315                 320 


Pro Pro Pro Ala Thr Thr Asp Pro Glu Gly Ala Tyr Glu Thr Val Lys 
                325                 330                 335     


Lys Glu Tyr Lys Arg Lys Trp Asn Ile Val Trp Leu Lys Pro Leu Gly 
            340                 345                 350         


Phe Asn Asn Thr Tyr Thr Leu Thr Val Lys Asp Glu Leu Ala Lys Gln 
        355                 360                 365             


Tyr Asn Leu Lys Thr Phe Ser Asp Leu Ala Lys Ile Ser Asp Lys Leu 
    370                 375                 380                 


Ile Leu Gly Ala Thr Met Phe Phe Leu Glu Gly Pro Asp Gly Tyr Pro 
385                 390                 395                 400 


Gly Leu Gln Lys Leu Tyr Asn Phe Lys Phe Lys His Thr Lys Ser Met 
                405                 410                 415     


Asp Met Gly Ile Arg Tyr Thr Ala Ile Asp Asn Asn Glu Val Gln Val 
            420                 425                 430         


Ile Asp Ala Trp Ala Thr Asp Gly Leu Leu Val Ser His Lys Leu Lys 
        435                 440                 445             


Ile Leu Glu Asp Asp Lys Gly Phe Phe Pro Pro Tyr Tyr Ala Ala Pro 
    450                 455                 460                 


Ile Ile Arg Gln Asp Val Leu Asp Lys His Pro Glu Leu Lys Asp Val 
465                 470                 475                 480 


Leu Asn Lys Leu Ala Asn Gln Ile Ser Leu Glu Glu Met Gln Lys Leu 
                485                 490                 495     


Asn Tyr Lys Val Asp Gly Glu Gly Gln Asp Pro Ala Lys Val Ala Lys 
            500                 505                 510         


Glu Phe Leu Lys Glu Lys Gly Leu Ile 
        515                 520     


<210>  15
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Ala Asn Asp Thr Val Val Val Gly Ser Ile Pro Phe Thr Glu Gly Ile 
1               5                   10                  15      


Ile Val Ala Asn Met Val Ala Glu Met Ile Glu Ala His Thr Asp Leu 
            20                  25                  30          


Lys Val Val Arg Lys Leu Asn Leu Gly Gly Ile Asn Val Asn Phe Glu 
        35                  40                  45              


Ala Ile Lys Arg Gly Gly Ala Asn Asn Gly Ile Asp Ile Tyr Val Glu 
    50                  55                  60                  


Tyr Thr Gly His Gly Leu Val Asp Ile Leu Gly Phe Pro Glu Pro Asn 
65                  70                  75                  80  


Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe 
                85                  90                  95      


Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His 
            100                 105                 110         


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
        115                 120                 125             


Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser Lys Asp Pro Asn Glu 
    130                 135                 140                 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
145                 150                 155                 160 


Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met 
                165                 170                 175     


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
            180                 185                 190         


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly 
        195                 200                 205             


Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
    210                 215                 220                 


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
225                 230                 235                 240 


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
                245                 250                 255     


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
            260                 265                 270         


Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys 
        275                 280                 285             


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
    290                 295                 300                 


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe 
305                 310                 315                 320 


Pro Pro Pro Ala Thr Thr Asp Pro Glu Gly Ala Tyr Glu Thr Val Lys 
                325                 330                 335     


Lys Glu Tyr Lys Arg Lys Trp Asn Ile Val Trp Leu Lys Pro Leu Gly 
            340                 345                 350         


Phe Asn Asn Thr Tyr Thr Leu Thr Val Lys Asp Glu Leu Ala Lys Gln 
        355                 360                 365             


Tyr Asn Leu Lys Thr Phe Ser Asp Leu Ala Lys Ile Ser Asp Lys Leu 
    370                 375                 380                 


Ile Leu Gly Ala Thr Met Phe Phe Leu Glu Gly Pro Asp Gly Tyr Pro 
385                 390                 395                 400 


Gly Leu Gln Lys Leu Tyr Asn Phe Lys Phe Lys His Thr Lys Ser Met 
                405                 410                 415     


Asp Met Gly Ile Arg Tyr Thr Ala Ile Asp Asn Asn Glu Val Gln Val 
            420                 425                 430         


Ile Asp Ala Trp Ala Thr Asp Gly Leu Leu Val Ser His Lys Leu Lys 
        435                 440                 445             


Ile Leu Glu Asp Asp Lys Gln Phe Phe Pro Pro Tyr Tyr Ala Ala Pro 
    450                 455                 460                 


Ile Ile Arg Gln Asp Val Leu Asp Lys His Pro Glu Leu Lys Asp Val 
465                 470                 475                 480 


Leu Asn Lys Leu Ala Asn Gln Ile Ser Leu Glu Glu Met Gln Lys Leu 
                485                 490                 495     


Asn Tyr Lys Val Asp Gly Glu Gly Gln Asp Pro Ala Lys Val Ala Lys 
            500                 505                 510         


Glu Phe Leu Lys Glu Lys Gly Leu Ile 
        515                 520     


<210>  16
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Ala Asn Asp Thr Val Val Val Gly Ser Ile Phe Phe Thr Glu Gly Ile 
1               5                   10                  15      


Ile Val Ala Asn Met Val Ala Glu Met Ile Glu Ala His Thr Asp Leu 
            20                  25                  30          


Lys Val Val Arg Lys Leu Asn Leu Gly Gly Val Asn Val Asn Phe Glu 
        35                  40                  45              


Ala Ile Lys Arg Gly Gly Ala Asn Asn Gly Ile Asp Ile Tyr Val Glu 
    50                  55                  60                  


Tyr Thr Gly His Gly Leu Val Asp Ile Leu Gly Phe Pro Glu Pro Asn 
65                  70                  75                  80  


Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe 
                85                  90                  95      


Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His 
            100                 105                 110         


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
        115                 120                 125             


Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser Lys Asp Pro Asn Glu 
    130                 135                 140                 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
145                 150                 155                 160 


Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met 
                165                 170                 175     


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
            180                 185                 190         


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly 
        195                 200                 205             


Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
    210                 215                 220                 


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
225                 230                 235                 240 


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
                245                 250                 255     


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
            260                 265                 270         


Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys 
        275                 280                 285             


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
    290                 295                 300                 


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe 
305                 310                 315                 320 


Pro Pro Pro Ala Thr Thr Asp Pro Glu Gly Ala Tyr Glu Thr Val Lys 
                325                 330                 335     


Lys Glu Tyr Lys Arg Lys Trp Asn Ile Val Trp Leu Lys Pro Leu Gly 
            340                 345                 350         


Phe Asn Asn Thr Tyr Thr Leu Thr Val Lys Asp Glu Leu Ala Lys Gln 
        355                 360                 365             


Tyr Asn Leu Lys Thr Phe Ser Asp Leu Ala Lys Ile Ser Asp Lys Leu 
    370                 375                 380                 


Ile Leu Gly Ala Thr Met Phe Phe Leu Glu Gly Pro Asp Gly Tyr Pro 
385                 390                 395                 400 


Gly Leu Gln Lys Leu Tyr Asn Phe Lys Phe Lys His Thr Lys Ser Met 
                405                 410                 415     


Asp Met Gly Ile Arg Tyr Thr Ala Ile Asp Asn Asn Glu Val Gln Val 
            420                 425                 430         


Ile Asp Ala Trp Ala Thr Asp Gly Leu Leu Val Ser His Lys Leu Lys 
        435                 440                 445             


Ile Leu Glu Asp Asp Lys Ala Phe Phe Pro Pro Tyr Tyr Ala Ala Pro 
    450                 455                 460                 


Ile Ile Arg Gln Asp Val Leu Asp Lys His Pro Glu Leu Lys Asp Val 
465                 470                 475                 480 


Leu Asn Lys Leu Ala Asn Gln Ile Ser Leu Glu Glu Met Gln Lys Leu 
                485                 490                 495     


Asn Tyr Lys Val Asp Gly Glu Gly Gln Asp Pro Ala Lys Val Ala Lys 
            500                 505                 510         


Glu Phe Leu Lys Glu Lys Gly Leu Ile 
        515                 520     


<210>  17
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Ala Asn Asp Thr Val Val Val Gly Ser Ile Leu Phe Thr Glu Gly Ile 
1               5                   10                  15      


Ile Val Ala Asn Met Val Ala Glu Met Ile Glu Ala His Thr Asp Leu 
            20                  25                  30          


Lys Val Val Arg Lys Leu Asn Leu Gly Gly Val Asn Val Asn Phe Glu 
        35                  40                  45              


Ala Ile Lys Arg Gly Gly Ala Asn Asn Gly Ile Asp Ile Tyr Val Glu 
    50                  55                  60                  


Tyr Thr Gly His Gly Leu Val Asp Ile Leu Gly Phe Pro Glu Pro Asn 
65                  70                  75                  80  


Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe 
                85                  90                  95      


Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His 
            100                 105                 110         


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
        115                 120                 125             


Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser Lys Asp Pro Asn Glu 
    130                 135                 140                 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
145                 150                 155                 160 


Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met 
                165                 170                 175     


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
            180                 185                 190         


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly 
        195                 200                 205             


Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
    210                 215                 220                 


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
225                 230                 235                 240 


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
                245                 250                 255     


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
            260                 265                 270         


Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys 
        275                 280                 285             


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
    290                 295                 300                 


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe 
305                 310                 315                 320 


Pro Pro Pro Ala Thr Thr Asp Pro Glu Gly Ala Tyr Glu Thr Val Lys 
                325                 330                 335     


Lys Glu Tyr Lys Arg Lys Trp Asn Ile Val Trp Leu Lys Pro Leu Gly 
            340                 345                 350         


Phe Asn Asn Thr Tyr Thr Leu Thr Val Lys Asp Glu Leu Ala Lys Gln 
        355                 360                 365             


Tyr Asn Leu Lys Thr Phe Ser Asp Leu Ala Lys Ile Ser Asp Lys Leu 
    370                 375                 380                 


Ile Leu Gly Ala Thr Met Phe Phe Leu Glu Gly Pro Asp Gly Tyr Pro 
385                 390                 395                 400 


Gly Leu Gln Lys Leu Tyr Asn Phe Lys Phe Lys His Thr Lys Ser Met 
                405                 410                 415     


Asp Met Gly Ile Arg Tyr Thr Ala Ile Asp Asn Asn Glu Val Gln Val 
            420                 425                 430         


Ile Asp Ala Trp Ala Thr Asp Gly Leu Leu Val Ser His Lys Leu Lys 
        435                 440                 445             


Ile Leu Glu Asp Asp Lys Ala Phe Phe Pro Pro Tyr Tyr Ala Ala Pro 
    450                 455                 460                 


Ile Ile Arg Gln Asp Val Leu Asp Lys His Pro Glu Leu Lys Asp Val 
465                 470                 475                 480 


Leu Asn Lys Leu Ala Asn Gln Ile Ser Leu Glu Glu Met Gln Lys Leu 
                485                 490                 495     


Asn Tyr Lys Val Asp Gly Glu Gly Gln Asp Pro Ala Lys Val Ala Lys 
            500                 505                 510         


Glu Phe Leu Lys Glu Lys Gly Leu Ile 
        515                 520     


<210>  18
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Ala Asn Asp Thr Val Val Val Gly Ser Ile Pro Phe Thr Glu Gly Ile 
1               5                   10                  15      


Ile Val Ala Asn Met Val Ala Glu Met Ile Glu Ala His Thr Asp Leu 
            20                  25                  30          


Lys Val Val Arg Lys Leu Asn Leu Gly Gly Val Asn Val Asn Phe Glu 
        35                  40                  45              


Ala Ile Lys Arg Gly Gly Ala Asn Asn Gly Ile Asp Ile Tyr Val Glu 
    50                  55                  60                  


Tyr Thr Gly His Gly Leu Val Asp Ile Leu Gly Phe Pro Glu Pro Asn 
65                  70                  75                  80  


Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe 
                85                  90                  95      


Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His 
            100                 105                 110         


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
        115                 120                 125             


Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser Lys Asp Pro Asn Glu 
    130                 135                 140                 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
145                 150                 155                 160 


Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met 
                165                 170                 175     


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
            180                 185                 190         


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly 
        195                 200                 205             


Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
    210                 215                 220                 


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
225                 230                 235                 240 


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
                245                 250                 255     


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
            260                 265                 270         


Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys 
        275                 280                 285             


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
    290                 295                 300                 


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe 
305                 310                 315                 320 


Pro Pro Pro Ala Thr Thr Asp Pro Glu Gly Ala Tyr Glu Thr Val Lys 
                325                 330                 335     


Lys Glu Tyr Lys Arg Lys Trp Asn Ile Val Trp Leu Lys Pro Leu Gly 
            340                 345                 350         


Phe Asn Asn Thr Tyr Thr Leu Thr Val Lys Asp Glu Leu Ala Lys Gln 
        355                 360                 365             


Tyr Asn Leu Lys Thr Phe Ser Asp Leu Ala Lys Ile Ser Asp Lys Leu 
    370                 375                 380                 


Ile Leu Gly Ala Thr Met Phe Phe Leu Glu Gly Pro Asp Gly Tyr Pro 
385                 390                 395                 400 


Gly Leu Gln Lys Leu Tyr Asn Phe Lys Phe Lys His Thr Lys Ser Met 
                405                 410                 415     


Asp Met Gly Ile Arg Tyr Thr Ala Ile Asp Asn Asn Glu Val Gln Val 
            420                 425                 430         


Ile Asp Ala Trp Ala Thr Asp Gly Leu Leu Val Ser His Lys Leu Lys 
        435                 440                 445             


Ile Leu Glu Asp Asp Lys Ala Phe Phe Pro Pro Tyr Tyr Ala Ala Pro 
    450                 455                 460                 


Ile Ile Arg Gln Asp Val Leu Asp Lys His Pro Glu Leu Lys Asp Val 
465                 470                 475                 480 


Leu Asn Lys Leu Ala Asn Gln Ile Ser Leu Glu Glu Met Gln Lys Leu 
                485                 490                 495     


Asn Tyr Lys Val Asp Gly Glu Gly Gln Asp Pro Ala Lys Val Ala Lys 
            500                 505                 510         


Glu Phe Leu Lys Glu Lys Gly Leu Ile 
        515                 520     


<210>  19
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Ala Asn Asp Thr Val Val Val Gly Ser Ile Asp Phe Thr Glu Gly Ile 
1               5                   10                  15      


Ile Val Ala Asn Met Val Ala Glu Met Ile Glu Ala His Thr Asp Leu 
            20                  25                  30          


Lys Val Val Arg Lys Leu Asn Leu Gly Gly Val Asn Val Asn Phe Glu 
        35                  40                  45              


Ala Ile Lys Arg Gly Gly Ala Asn Asn Gly Ile Asp Ile Tyr Val Glu 
    50                  55                  60                  


Tyr Thr Gly His Gly Leu Val Asp Ile Leu Gly Phe Pro Glu Pro Asn 
65                  70                  75                  80  


Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe 
                85                  90                  95      


Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His 
            100                 105                 110         


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
        115                 120                 125             


Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser Lys Asp Pro Asn Glu 
    130                 135                 140                 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
145                 150                 155                 160 


Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met 
                165                 170                 175     


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
            180                 185                 190         


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly 
        195                 200                 205             


Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
    210                 215                 220                 


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
225                 230                 235                 240 


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
                245                 250                 255     


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
            260                 265                 270         


Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys 
        275                 280                 285             


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
    290                 295                 300                 


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe 
305                 310                 315                 320 


Pro Pro Pro Ala Thr Thr Asp Pro Glu Gly Ala Tyr Glu Thr Val Lys 
                325                 330                 335     


Lys Glu Tyr Lys Arg Lys Trp Asn Ile Val Trp Leu Lys Pro Leu Gly 
            340                 345                 350         


Phe Asn Asn Thr Tyr Thr Leu Thr Val Lys Asp Glu Leu Ala Lys Gln 
        355                 360                 365             


Tyr Asn Leu Lys Thr Phe Ser Asp Leu Ala Lys Ile Ser Asp Lys Leu 
    370                 375                 380                 


Ile Leu Gly Ala Thr Met Phe Phe Leu Glu Gly Pro Asp Gly Tyr Pro 
385                 390                 395                 400 


Gly Leu Gln Lys Leu Tyr Asn Phe Lys Phe Lys His Thr Lys Ser Met 
                405                 410                 415     


Asp Met Gly Ile Arg Tyr Thr Ala Ile Asp Asn Asn Glu Val Gln Val 
            420                 425                 430         


Ile Asp Ala Trp Ala Thr Asp Gly Leu Leu Val Ser His Lys Leu Lys 
        435                 440                 445             


Ile Leu Glu Asp Asp Lys Ala Phe Phe Pro Pro Tyr Tyr Ala Ala Pro 
    450                 455                 460                 


Ile Ile Arg Gln Asp Val Leu Asp Lys His Pro Glu Leu Lys Asp Val 
465                 470                 475                 480 


Leu Asn Lys Leu Ala Asn Gln Ile Ser Leu Glu Glu Met Gln Lys Leu 
                485                 490                 495     


Asn Tyr Lys Val Asp Gly Glu Gly Gln Asp Pro Ala Lys Val Ala Lys 
            500                 505                 510         


Glu Phe Leu Lys Glu Lys Gly Leu Ile 
        515                 520     


<210>  20
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Ala Asn Asp Thr Val Val Val Gly Ser Val Glu Phe Thr Glu Gly Ile 
1               5                   10                  15      


Ile Val Ala Asn Met Val Ala Glu Met Ile Glu Ala His Thr Asp Leu 
            20                  25                  30          


Lys Val Val Arg Lys Leu Asn Leu Gly Gly Val Asn Val Asn Phe Glu 
        35                  40                  45              


Ala Ile Lys Arg Gly Gly Ala Asn Asn Gly Ile Asp Ile Tyr Val Glu 
    50                  55                  60                  


Tyr Thr Gly Thr Gly Leu Val Asp Ile Leu Gly Phe Pro Glu Pro Asn 
65                  70                  75                  80  


Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe 
                85                  90                  95      


Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His 
            100                 105                 110         


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
        115                 120                 125             


Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser Lys Asp Pro Asn Glu 
    130                 135                 140                 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
145                 150                 155                 160 


Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met 
                165                 170                 175     


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
            180                 185                 190         


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly 
        195                 200                 205             


Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
    210                 215                 220                 


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
225                 230                 235                 240 


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
                245                 250                 255     


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
            260                 265                 270         


Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys 
        275                 280                 285             


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
    290                 295                 300                 


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe 
305                 310                 315                 320 


Pro Pro Pro Ser Ser Thr Asp Pro Glu Gly Ala Tyr Glu Thr Val Lys 
                325                 330                 335     


Lys Glu Tyr Lys Arg Lys Trp Asn Ile Val Trp Leu Lys Pro Leu Gly 
            340                 345                 350         


Phe Asn Asn Thr Tyr Thr Leu Thr Val Lys Asp Glu Leu Ala Lys Gln 
        355                 360                 365             


Tyr Asn Leu Lys Thr Phe Ser Asp Leu Ala Lys Ile Ser Asp Lys Leu 
    370                 375                 380                 


Ile Leu Gly Ala Thr Met Phe Phe Leu Glu Gly Pro Asp Gly Tyr Pro 
385                 390                 395                 400 


Gly Leu Gln Lys Leu Tyr Asn Phe Lys Phe Lys His Thr Lys Ser Met 
                405                 410                 415     


Asp Met Gly Ile Arg Tyr Thr Ala Ile Asp Asn Asn Glu Val Gln Val 
            420                 425                 430         


Ile Asp Ala Trp Ala Thr Asp Gly Leu Leu Val Ser His Lys Leu Lys 
        435                 440                 445             


Ile Leu Glu Asp Asp Lys Ala Phe Phe Pro Pro Tyr Tyr Ala Ala Pro 
    450                 455                 460                 


Ile Ile Arg Gln Asp Val Leu Asp Lys His Pro Glu Leu Lys Asp Val 
465                 470                 475                 480 


Leu Asn Lys Leu Ala Asn Gln Ile Ser Leu Glu Glu Met Gln Lys Leu 
                485                 490                 495     


Asn Tyr Lys Val Asp Gly Glu Gly Gln Asp Pro Ala Lys Val Ala Lys 
            500                 505                 510         


Glu Phe Leu Lys Glu Lys Gly Leu Ile 
        515                 520     


<210>  21
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21

Ala Asn Asp Thr Val Val Val Gly Ser Ala Glu Phe Thr Glu Gly Ile 
1               5                   10                  15      


Ile Val Ala Asn Met Val Ala Glu Met Ile Glu Ala His Thr Asp Leu 
            20                  25                  30          


Lys Val Val Arg Lys Leu Asn Leu Gly Gly Val Asn Val Asn Phe Glu 
        35                  40                  45              


Ala Ile Lys Arg Gly Gly Ala Asn Asn Gly Ile Asp Ile Tyr Val Glu 
    50                  55                  60                  


Tyr Thr Gly Thr Gly Leu Val Asp Ile Leu Gly Phe Pro Glu Pro Asn 
65                  70                  75                  80  


Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe 
                85                  90                  95      


Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His 
            100                 105                 110         


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
        115                 120                 125             


Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser Lys Asp Pro Asn Glu 
    130                 135                 140                 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
145                 150                 155                 160 


Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met 
                165                 170                 175     


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
            180                 185                 190         


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly 
        195                 200                 205             


Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
    210                 215                 220                 


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
225                 230                 235                 240 


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
                245                 250                 255     


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
            260                 265                 270         


Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys 
        275                 280                 285             


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
    290                 295                 300                 


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe 
305                 310                 315                 320 


Pro Pro Pro Ser Ser Thr Asp Pro Glu Gly Ala Tyr Glu Thr Val Lys 
                325                 330                 335     


Lys Glu Tyr Lys Arg Lys Trp Asn Ile Val Trp Leu Lys Pro Leu Gly 
            340                 345                 350         


Phe Asn Asn Thr Tyr Thr Leu Thr Val Lys Asp Glu Leu Ala Lys Gln 
        355                 360                 365             


Tyr Asn Leu Lys Thr Phe Ser Asp Leu Ala Lys Ile Ser Asp Lys Leu 
    370                 375                 380                 


Ile Leu Gly Ala Thr Met Phe Phe Leu Glu Gly Pro Asp Gly Tyr Pro 
385                 390                 395                 400 


Gly Leu Gln Lys Leu Tyr Asn Phe Lys Phe Lys His Thr Lys Ser Met 
                405                 410                 415     


Asp Met Gly Ile Arg Tyr Thr Ala Ile Asp Asn Asn Glu Val Gln Val 
            420                 425                 430         


Ile Asp Ala Trp Ala Thr Asp Gly Leu Leu Val Ser His Lys Leu Lys 
        435                 440                 445             


Ile Leu Glu Asp Asp Lys Ala Phe Phe Pro Pro Tyr Tyr Ala Ala Pro 
    450                 455                 460                 


Ile Ile Arg Gln Asp Val Leu Asp Lys His Pro Glu Leu Lys Asp Val 
465                 470                 475                 480 


Leu Asn Lys Leu Ala Asn Gln Ile Ser Leu Glu Glu Met Gln Lys Leu 
                485                 490                 495     


Asn Tyr Lys Val Asp Gly Glu Gly Gln Asp Pro Ala Lys Val Ala Lys 
            500                 505                 510         


Glu Phe Leu Lys Glu Lys Gly Leu Ile 
        515                 520     


<210>  22
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22

Ala Asn Asp Thr Val Val Val Gly Ser Met Glu Phe Thr Glu Gly Ile 
1               5                   10                  15      


Ile Val Ala Asn Met Val Ala Glu Met Ile Glu Ala His Thr Asp Leu 
            20                  25                  30          


Lys Val Val Arg Lys Leu Asn Leu Gly Gly Val Asn Val Asn Phe Glu 
        35                  40                  45              


Ala Ile Lys Arg Gly Gly Ala Asn Asn Gly Ile Asp Ile Tyr Val Glu 
    50                  55                  60                  


Tyr Thr Gly Thr Gly Leu Val Asp Ile Leu Gly Phe Pro Glu Pro Asn 
65                  70                  75                  80  


Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe 
                85                  90                  95      


Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His 
            100                 105                 110         


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
        115                 120                 125             


Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser Lys Asp Pro Asn Glu 
    130                 135                 140                 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
145                 150                 155                 160 


Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met 
                165                 170                 175     


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
            180                 185                 190         


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly 
        195                 200                 205             


Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
    210                 215                 220                 


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
225                 230                 235                 240 


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
                245                 250                 255     


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
            260                 265                 270         


Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys 
        275                 280                 285             


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
    290                 295                 300                 


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe 
305                 310                 315                 320 


Pro Pro Pro Ser Ser Thr Asp Pro Glu Gly Ala Tyr Glu Thr Val Lys 
                325                 330                 335     


Lys Glu Tyr Lys Arg Lys Trp Asn Ile Val Trp Leu Lys Pro Leu Gly 
            340                 345                 350         


Phe Asn Asn Thr Tyr Thr Leu Thr Val Lys Asp Glu Leu Ala Lys Gln 
        355                 360                 365             


Tyr Asn Leu Lys Thr Phe Ser Asp Leu Ala Lys Ile Ser Asp Lys Leu 
    370                 375                 380                 


Ile Leu Gly Ala Thr Met Phe Phe Leu Glu Gly Pro Asp Gly Tyr Pro 
385                 390                 395                 400 


Gly Leu Gln Lys Leu Tyr Asn Phe Lys Phe Lys His Thr Lys Ser Met 
                405                 410                 415     


Asp Met Gly Ile Arg Tyr Thr Ala Ile Asp Asn Asn Glu Val Gln Val 
            420                 425                 430         


Ile Asp Ala Trp Ala Thr Asp Gly Leu Leu Val Ser His Lys Leu Lys 
        435                 440                 445             


Ile Leu Glu Asp Asp Lys Ala Phe Phe Pro Pro Tyr Tyr Ala Ala Pro 
    450                 455                 460                 


Ile Ile Arg Gln Asp Val Leu Asp Lys His Pro Glu Leu Lys Asp Val 
465                 470                 475                 480 


Leu Asn Lys Leu Ala Asn Gln Ile Ser Leu Glu Glu Met Gln Lys Leu 
                485                 490                 495     


Asn Tyr Lys Val Asp Gly Glu Gly Gln Asp Pro Ala Lys Val Ala Lys 
            500                 505                 510         


Glu Phe Leu Lys Glu Lys Gly Leu Ile 
        515                 520     


<210>  23
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Ala Asn Asp Thr Val Val Val Gly Ser Ala Asn Phe Thr Glu Gly Ile 
1               5                   10                  15      


Ile Val Ala Asn Met Val Ala Glu Met Ile Glu Ala His Thr Asp Leu 
            20                  25                  30          


Lys Val Val Arg Lys Leu Asn Leu Gly Gly Glu Asn Val Asn Phe Glu 
        35                  40                  45              


Ala Ile Lys Arg Gly Gly Ala Asn Asn Gly Ile Asp Ile Tyr Val Glu 
    50                  55                  60                  


Tyr Thr Gly His Gly Leu Val Asp Ile Leu Gly Phe Pro Glu Pro Asn 
65                  70                  75                  80  


Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe 
                85                  90                  95      


Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His 
            100                 105                 110         


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
        115                 120                 125             


Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser Lys Asp Pro Asn Glu 
    130                 135                 140                 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
145                 150                 155                 160 


Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met 
                165                 170                 175     


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
            180                 185                 190         


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly 
        195                 200                 205             


Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
    210                 215                 220                 


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser 
225                 230                 235                 240 


Trp Gly Val Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His 
                245                 250                 255     


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
            260                 265                 270         


Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys 
        275                 280                 285             


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
    290                 295                 300                 


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe 
305                 310                 315                 320 


Ala Pro Pro Pro Ser Thr Asp Pro Glu Gly Ala Tyr Glu Thr Val Lys 
                325                 330                 335     


Lys Glu Tyr Lys Arg Lys Trp Asn Ile Val Trp Leu Lys Pro Leu Gly 
            340                 345                 350         


Phe Asn Asn Thr Gly Thr Leu Thr Val Lys Asp Glu Leu Ala Lys Gln 
        355                 360                 365             


Tyr Asn Leu Lys Thr Phe Ser Asp Leu Ala Lys Ile Ser Asp Lys Leu 
    370                 375                 380                 


Ile Leu Gly Ala Thr Met Phe Phe Leu Glu Ala Pro Asp Gly Tyr Pro 
385                 390                 395                 400 


Gly Leu Gln Lys Leu Tyr Asn Phe Lys Phe Lys His Thr Lys Ser Met 
                405                 410                 415     


Asp Met Gly Ile Arg Tyr Thr Ala Ile Asp Asn Asn Glu Val Gln Val 
            420                 425                 430         


Ile Asp Ala Trp Ala Thr Asp Gly Leu Leu Val Ser His Lys Leu Lys 
        435                 440                 445             


Ile Leu Glu Asp Asp Lys Ala Phe Phe Pro Pro Tyr Tyr Ala Ala Pro 
    450                 455                 460                 


Ile Ile Arg Gln Asp Val Leu Asp Lys His Pro Glu Leu Lys Asp Val 
465                 470                 475                 480 


Leu Asn Lys Leu Ala Asn Gln Ile Ser Leu Glu Glu Met Gln Lys Leu 
                485                 490                 495     


Asn Tyr Lys Val Asp Gly Glu Gly Gln Asp Pro Ala Lys Val Ala Lys 
            500                 505                 510         


Glu Phe Leu Lys Glu Lys Gly Leu Ile 
        515                 520     


<210>  24
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Ala Asn Asp Thr Val Val Val Gly Ser Ile Glu Phe Thr Glu Gly Ile 
1               5                   10                  15      


Ile Val Ala Asn Met Val Ala Glu Met Ile Glu Ala His Thr Asp Leu 
            20                  25                  30          


Lys Val Val Arg Lys Leu Asn Leu Gly Gly Glu Asn Val Asn Phe Glu 
        35                  40                  45              


Ala Ile Lys Arg Gly Gly Ala Asn Asn Gly Ile Asp Ile Tyr Val Glu 
    50                  55                  60                  


Tyr Thr Gly His Gly Leu Val Asp Ile Leu Gly Phe Pro Glu Pro Asn 
65                  70                  75                  80  


Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe 
                85                  90                  95      


Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His 
            100                 105                 110         


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
        115                 120                 125             


Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser Lys Asp Pro Asn Glu 
    130                 135                 140                 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
145                 150                 155                 160 


Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met 
                165                 170                 175     


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
            180                 185                 190         


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly 
        195                 200                 205             


Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
    210                 215                 220                 


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser 
225                 230                 235                 240 


Trp Gly Val Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His 
                245                 250                 255     


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
            260                 265                 270         


Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys 
        275                 280                 285             


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
    290                 295                 300                 


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe 
305                 310                 315                 320 


Glu Pro Pro Ser Ser Thr Asp Pro Glu Gly Ala Tyr Glu Thr Val Lys 
                325                 330                 335     


Lys Glu Tyr Lys Arg Lys Trp Asn Ile Val Trp Leu Lys Pro Leu Gly 
            340                 345                 350         


Phe Asn Asn Thr Tyr Thr Leu Thr Val Lys Asp Glu Leu Ala Lys Gln 
        355                 360                 365             


Tyr Asn Leu Lys Thr Phe Ser Asp Leu Ala Lys Ile Ser Asp Lys Leu 
    370                 375                 380                 


Ile Leu Gly Ala Thr Met Phe Phe Leu Glu Gly Pro Asp Gly Tyr Pro 
385                 390                 395                 400 


Gly Leu Gln Lys Leu Tyr Asn Phe Lys Phe Lys His Thr Lys Ser Met 
                405                 410                 415     


Asp Met Gly Ile Arg Tyr Thr Ala Ile Asp Asn Asn Glu Val Gln Val 
            420                 425                 430         


Ile Asp Ala Ala Ala Thr Asp Gly Leu Leu Val Ser His Lys Leu Lys 
        435                 440                 445             


Ile Leu Glu Asp Asp Lys Ala Phe Phe Pro Pro Tyr Tyr Ala Ala Pro 
    450                 455                 460                 


Ile Ile Arg Gln Asp Val Leu Asp Lys His Pro Glu Leu Lys Asp Val 
465                 470                 475                 480 


Leu Asn Lys Leu Ala Asn Gln Ile Ser Leu Glu Glu Met Gln Lys Leu 
                485                 490                 495     


Asn Tyr Lys Val Asp Gly Glu Gly Gln Asp Pro Ala Lys Val Ala Lys 
            500                 505                 510         


Glu Phe Leu Lys Glu Lys Gly Leu Ile 
        515                 520     


<210>  25
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Ala Asn Asp Thr Val Val Val Gly Ser Ile Val Phe Thr Glu Gly Ile 
1               5                   10                  15      


Ile Val Ala Asn Met Val Ala Glu Met Ile Glu Ala His Thr Asp Leu 
            20                  25                  30          


Lys Val Val Arg Lys Leu Asn Leu Gly Gly Glu Asn Val Asn Phe Glu 
        35                  40                  45              


Ala Ile Lys Arg Gly Gly Ala Asn Asn Gly Ile Asp Ile Tyr Val Glu 
    50                  55                  60                  


Tyr Thr Gly His Gly Leu Val Asp Ile Leu Gly Phe Pro Glu Pro Asn 
65                  70                  75                  80  


Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe 
                85                  90                  95      


Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His 
            100                 105                 110         


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
        115                 120                 125             


Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser Lys Asp Pro Asn Glu 
    130                 135                 140                 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
145                 150                 155                 160 


Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met 
                165                 170                 175     


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
            180                 185                 190         


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly 
        195                 200                 205             


Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
    210                 215                 220                 


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser 
225                 230                 235                 240 


Trp Gly Val Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His 
                245                 250                 255     


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
            260                 265                 270         


Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys 
        275                 280                 285             


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
    290                 295                 300                 


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe 
305                 310                 315                 320 


Pro Pro Pro Ser Ser Thr Asp Pro Glu Gly Ala Tyr Glu Thr Val Lys 
                325                 330                 335     


Lys Glu Tyr Lys Arg Lys Trp Asn Ile Val Trp Leu Lys Pro Leu Gly 
            340                 345                 350         


Phe Asn Asn Thr Tyr Thr Leu Thr Val Lys Asp Glu Leu Ala Lys Gln 
        355                 360                 365             


Tyr Asn Leu Lys Thr Phe Ser Asp Leu Ala Lys Ile Ser Asp Lys Leu 
    370                 375                 380                 


Ile Leu Gly Ala Thr Met Phe Phe Leu Glu Gly Pro Asp Gly Tyr Pro 
385                 390                 395                 400 


Gly Leu Gln Lys Leu Tyr Asn Phe Lys Phe Lys His Thr Lys Ser Met 
                405                 410                 415     


Asp Met Gly Ile Arg Tyr Thr Ala Ile Asp Asn Asn Glu Val Gln Val 
            420                 425                 430         


Ile Asp Ala Phe Ala Thr Asp Gly Leu Leu Val Ser His Lys Leu Lys 
        435                 440                 445             


Ile Leu Glu Asp Asp Lys Ala Phe Phe Pro Pro Tyr Tyr Ala Ala Pro 
    450                 455                 460                 


Ile Ile Arg Gln Asp Val Leu Asp Lys His Pro Glu Leu Lys Asp Val 
465                 470                 475                 480 


Leu Asn Lys Leu Ala Asn Gln Ile Ser Ala Glu Glu Met Gln Lys Leu 
                485                 490                 495     


Asn Tyr Lys Val Asp Gly Glu Gly Gln Asp Pro Ala Lys Val Ala Lys 
            500                 505                 510         


Glu Phe Leu Lys Glu Lys Gly Leu Ile 
        515                 520     


<210>  26
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26

Ala Asn Asp Thr Val Val Val Gly Ser Ile Asn Phe Thr Glu Gln Ile 
1               5                   10                  15      


Ile Val Ala Asn Met Val Ala Glu Met Ile Glu Ala His Thr Asp Leu 
            20                  25                  30          


Lys Val Val Arg Lys Leu Asn Leu Gly Gly Thr Asn Val Asn Phe Glu 
        35                  40                  45              


Ala Ile Lys Arg Gly Gly Ala Asn Asn Gly Ile Asp Ile Tyr Val Glu 
    50                  55                  60                  


Tyr Thr Gly Thr Gly Leu Val Asp Ile Leu Gly Phe Pro Glu Pro Asn 
65                  70                  75                  80  


Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe 
                85                  90                  95      


Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His 
            100                 105                 110         


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
        115                 120                 125             


Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser Lys Asp Pro Asn Glu 
    130                 135                 140                 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
145                 150                 155                 160 


Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met 
                165                 170                 175     


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
            180                 185                 190         


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly 
        195                 200                 205             


Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
    210                 215                 220                 


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
225                 230                 235                 240 


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
                245                 250                 255     


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
            260                 265                 270         


Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys 
        275                 280                 285             


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
    290                 295                 300                 


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe 
305                 310                 315                 320 


Pro Pro Pro Pro Ser Thr Asp Pro Glu Gly Ala Tyr Glu Thr Val Lys 
                325                 330                 335     


Lys Glu Tyr Lys Arg Lys Trp Asn Ile Val Trp Leu Lys Pro Leu Gly 
            340                 345                 350         


Phe Asn Asn Thr Tyr Thr Leu Ala Val Lys Asp Glu Leu Ala Lys Gln 
        355                 360                 365             


Tyr Asn Leu Lys Thr Phe Ser Asp Leu Ala Lys Ile Ser Asp Lys Leu 
    370                 375                 380                 


Ile Leu Gly Ala Thr Met Phe Phe Leu Glu Lys Pro Asp Gly Tyr Pro 
385                 390                 395                 400 


Gly Leu Gln Lys Leu Tyr Asn Phe Lys Phe Lys His Thr Lys Ser Met 
                405                 410                 415     


Asp Met Gly Ile Arg Tyr Thr Ala Ile Asp Asn Asn Glu Val Gln Val 
            420                 425                 430         


Ile Asp Ala Phe Ala Thr Asp Gly Leu Leu Val Ser His Lys Leu Lys 
        435                 440                 445             


Ile Leu Glu Asp Asp Lys His Phe Phe Pro Pro Tyr Tyr Ala Ala Pro 
    450                 455                 460                 


Ile Ile Arg Gln Asp Val Leu Asp Lys His Pro Glu Leu Lys Asp Val 
465                 470                 475                 480 


Leu Asn Lys Leu Ala Asn Gln Ile Ser Asp Glu Glu Met Gln Lys Leu 
                485                 490                 495     


Asn Tyr Lys Val Asp Gly Glu Gly Gln Asp Pro Ala Lys Val Ala Lys 
            500                 505                 510         


Glu Phe Leu Lys Glu Lys Gly Leu Ile Leu 
        515                 520         


<210>  27
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27

Ala Asn Asp Thr Val Val Val Gly Ser Ile Asn Phe Thr Glu Gly Ile 
1               5                   10                  15      


Ile Val Ala Asn Met Val Ala Glu Met Ile Glu Ala His Thr Asp Leu 
            20                  25                  30          


Lys Val Val Arg Lys Leu Asn Leu Gly Gly Glu Asn Val Asn Phe Glu 
        35                  40                  45              


Ala Ile Lys Arg Gly Gly Ala Asn Asn Gly Ile Asp Ile Tyr Val Glu 
    50                  55                  60                  


Tyr Thr Gly His Gly Leu Val Asp Ile Leu Gly Phe Pro Glu Pro Asn 
65                  70                  75                  80  


Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe 
                85                  90                  95      


Lys Ile Arg His Asn Met Glu Asp Gly Ser Val Gln Leu Ala Asp His 
            100                 105                 110         


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
        115                 120                 125             


Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser Lys Asp Pro Asn Glu 
    130                 135                 140                 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
145                 150                 155                 160 


Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met 
                165                 170                 175     


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
            180                 185                 190         


Leu Asp Gly Gly Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly 
        195                 200                 205             


Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
    210                 215                 220                 


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
225                 230                 235                 240 


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
                245                 250                 255     


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
            260                 265                 270         


Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys 
        275                 280                 285             


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
    290                 295                 300                 


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe 
305                 310                 315                 320 


Pro Pro Pro Ser Ser Thr Asp Pro Glu Gly Ala Tyr Glu Thr Val Lys 
                325                 330                 335     


Lys Glu Tyr Lys Arg Lys Trp Asn Ile Val Trp Leu Lys Pro Leu Gly 
            340                 345                 350         


Phe Asn Asn Thr Tyr Thr Leu Thr Val Lys Asp Glu Leu Ala Lys Gln 
        355                 360                 365             


Tyr Asn Leu Lys Thr Phe Ser Asp Leu Ala Lys Ile Ser Asp Lys Leu 
    370                 375                 380                 


Ile Leu Gly Ala Thr Met Phe Phe Leu Glu Gly Pro Asp Gly Tyr Pro 
385                 390                 395                 400 


Gly Leu Gln Lys Leu Tyr Asn Phe Lys Phe Lys His Thr Lys Ser Met 
                405                 410                 415     


Asp Met Gly Ile Arg Tyr Thr Ala Ile Asp Asn Asn Glu Val Gln Val 
            420                 425                 430         


Ile Asp Ala Trp Ala Thr Asp Gly Leu Leu Val Ser His Lys Leu Lys 
        435                 440                 445             


Ile Leu Glu Asp Asp Lys Ala Phe Phe Pro Pro Tyr Tyr Ala Ala Pro 
    450                 455                 460                 


Ile Ile Arg Gln Asp Val Leu Asp Lys His Pro Glu Leu Lys Asp Val 
465                 470                 475                 480 


Leu Asn Lys Leu Ala Asn Gln Ile Ser Leu Glu Glu Met Gln Lys Leu 
                485                 490                 495     


Asn Tyr Lys Val Asp Gly Glu Gly Gln Asp Pro Ala Lys Val Ala Lys 
            500                 505                 510         


Glu Phe Leu Lys Glu Lys Gly Leu Ile 
        515                 520     


<210>  28
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28

Ala Asn Asp Thr Val Val Val Gly Ser Lys Asn Phe Thr Glu Gln Ile 
1               5                   10                  15      


Ile Val Ala Asn Met Val Ala Glu Met Ile Glu Ala His Thr Asp Leu 
            20                  25                  30          


Lys Val Val Arg Lys Leu Asn Leu Gly Gly Thr Asn Val Asn Phe Glu 
        35                  40                  45              


Ala Ile Lys Arg Gly Gly Ala Asn Asn Gly Ile Asp Ile Tyr Val Glu 
    50                  55                  60                  


Tyr Thr Gly Thr Gly Leu Val Asp Ile Leu Gly Thr Thr Asp Pro Glu 
65                  70                  75                  80  


Lys Ala Tyr Glu Thr Val Lys Lys Glu Tyr Lys Asp Lys Trp Asn Ile 
                85                  90                  95      


Val Trp Leu Lys Pro Leu Gly Phe Asn Asn Thr Tyr Thr Leu Ala Val 
            100                 105                 110         


Lys Asp Glu Leu Ala Lys Gln Tyr Asn Leu Lys Thr Phe Ser Asp Leu 
        115                 120                 125             


Ala Lys Ile Ser Asp Lys Leu Ile Leu Gly Ala Thr Met Glu Phe Leu 
    130                 135                 140                 


Glu Arg Pro Asp Gly Tyr Pro Gly Leu Gln Lys Val Tyr Asn Phe Lys 
145                 150                 155                 160 


Phe Lys His Thr Lys Ser Met Asp Met Gly Ile Arg Tyr Thr Ala Ile 
                165                 170                 175     


Asp Asn Asn Glu Val Gln Val Ile Asp Ala Phe Ala Thr Asp Gly Leu 
            180                 185                 190         


Leu Val Ser His Lys Leu Lys Ile Leu Glu Asp Asp Lys His Phe Phe 
        195                 200                 205             


Pro Pro Tyr Tyr Ala Ala Pro Ile Ile Arg Gln Asp Val Leu Asp Lys 
    210                 215                 220                 


His Pro Glu Leu Lys Asp Val Leu Asn Lys Leu Ala Asn Gln Ile Ser 
225                 230                 235                 240 


Asp Glu Glu Met Gln Lys Leu Asn Tyr Lys Val Asp Gly Glu Gly Gln 
                245                 250                 255     


Asp Pro Ala Lys Val Ala Lys Glu Phe Leu Lys Glu Lys Gly Leu Ile 
            260                 265                 270         


<210>  29
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29

Ala Asn Asp Thr Val Val Val Gly Ser Lys Asn Phe Thr Glu Gln Ile 
1               5                   10                  15      


Ile Val Ala Asn Met Val Ala Glu Met Ile Glu Ala His Thr Asp Leu 
            20                  25                  30          


Lys Val Val Arg Lys Leu Asn Leu Gly Gly Thr Asn Val Asn Phe Glu 
        35                  40                  45              


Ala Ile Lys Arg Gly Gly Ala Asn Asn Gly Ile Asp Ile Tyr Val Glu 
    50                  55                  60                  


Tyr Thr Gly Thr Gly Leu Val Asp Ile Leu Gly Phe Pro Glu Pro Asn 
65                  70                  75                  80  


Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe 
                85                  90                  95      


Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His 
            100                 105                 110         


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
        115                 120                 125             


Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser Lys Asp Pro Asn Glu 
    130                 135                 140                 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
145                 150                 155                 160 


Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met 
                165                 170                 175     


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
            180                 185                 190         


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly 
        195                 200                 205             


Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
    210                 215                 220                 


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
225                 230                 235                 240 


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
                245                 250                 255     


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
            260                 265                 270         


Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys 
        275                 280                 285             


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
    290                 295                 300                 


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe 
305                 310                 315                 320 


Pro Pro Pro Pro Thr Thr Asp Pro Glu Lys Ala Tyr Glu Thr Val Lys 
                325                 330                 335     


Lys Glu Tyr Lys Asp Lys Trp Asn Ile Val Trp Leu Lys Pro Leu Gly 
            340                 345                 350         


Phe Asn Asn Thr Tyr Thr Leu Ala Val Lys Asp Glu Leu Ala Lys Gln 
        355                 360                 365             


Tyr Asn Leu Lys Thr Phe Ser Asp Leu Ala Lys Ile Ser Asp Lys Leu 
    370                 375                 380                 


Ile Leu Gly Ala Thr Met Glu Phe Leu Glu Arg Pro Asp Gly Tyr Pro 
385                 390                 395                 400 


Gly Leu Gln Lys Val Tyr Asn Phe Lys Phe Lys His Thr Lys Ser Met 
                405                 410                 415     


Asp Met Gly Ile Arg Tyr Thr Ala Ile Asp Asn Asn Glu Val Gln Val 
            420                 425                 430         


Ile Asp Ala Phe Ala Thr Asp Gly Leu Leu Val Ser His Lys Leu Lys 
        435                 440                 445             


Ile Leu Glu Asp Asp Lys His Phe Phe Pro Pro Tyr Tyr Ala Ala Pro 
    450                 455                 460                 


Ile Ile Arg Gln Asp Val Leu Asp Lys His Pro Glu Leu Lys Asp Val 
465                 470                 475                 480 


Leu Asn Lys Leu Ala Asn Gln Ile Ser Asp Glu Glu Met Gln Lys Leu 
                485                 490                 495     


Asn Tyr Lys Val Asp Gly Glu Gly Gln Asp Pro Ala Lys Val Ala Lys 
            500                 505                 510         


Glu Phe Leu Lys Glu Lys Gly Leu Ile 
        515                 520     


<210>  30
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30

Ala Asn Asp Thr Val Val Val Gly Ser Lys Asn Phe Thr Glu Gln Ile 
1               5                   10                  15      


Ile Val Ala Asn Met Val Ala Glu Met Ile Glu Ala His Thr Asp Leu 
            20                  25                  30          


Lys Val Val Arg Lys Leu Asn Leu Gly Gly Thr Asn Val Asn Phe Glu 
        35                  40                  45              


Ala Ile Lys Arg Gly Gly Ala Asn Asn Gly Ile Asp Ile Tyr Val Glu 
    50                  55                  60                  


Tyr Thr Gly Thr Gly Leu Val Asp Ile Leu Gly 
65                  70                  75  


<210>  31
<211>  197
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31

Thr Thr Asp Pro Glu Lys Ala Tyr Glu Thr Val Lys Lys Glu Tyr Lys 
1               5                   10                  15      


Asp Lys Trp Asn Ile Val Trp Leu Lys Pro Leu Gly Phe Asn Asn Thr 
            20                  25                  30          


Tyr Thr Leu Ala Val Lys Asp Glu Leu Ala Lys Gln Tyr Asn Leu Lys 
        35                  40                  45              


Thr Phe Ser Asp Leu Ala Lys Ile Ser Asp Lys Leu Ile Leu Gly Ala 
    50                  55                  60                  


Thr Met Glu Phe Leu Glu Arg Pro Asp Gly Tyr Pro Gly Leu Gln Lys 
65                  70                  75                  80  


Val Tyr Asn Phe Lys Phe Lys His Thr Lys Ser Met Asp Met Gly Ile 
                85                  90                  95      


Arg Tyr Thr Ala Ile Asp Asn Asn Glu Val Gln Val Ile Asp Ala Phe 
            100                 105                 110         


Ala Thr Asp Gly Leu Leu Val Ser His Lys Leu Lys Ile Leu Glu Asp 
        115                 120                 125             


Asp Lys His Phe Phe Pro Pro Tyr Tyr Ala Ala Pro Ile Ile Arg Gln 
    130                 135                 140                 


Asp Val Leu Asp Lys His Pro Glu Leu Lys Asp Val Leu Asn Lys Leu 
145                 150                 155                 160 


Ala Asn Gln Ile Ser Asp Glu Glu Met Gln Lys Leu Asn Tyr Lys Val 
                165                 170                 175     


Asp Gly Glu Gly Gln Asp Pro Ala Lys Val Ala Lys Glu Phe Leu Lys 
            180                 185                 190         


Glu Lys Gly Leu Ile 
        195         


<210>  32
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32

Ala Asn Asp Thr Val Val Val Gly Ser Ile Asn Phe Thr Glu Gln Ile 
1               5                   10                  15      


Ile Val Ala Asn Met Val Ala Glu Met Ile Glu Ala His Thr Asp Leu 
            20                  25                  30          


Lys Val Val Arg Lys Leu Asn Leu Gly Gly Thr Asn Val Asn Phe Glu 
        35                  40                  45              


Ala Ile Lys Arg Gly Gly Ala Asn Asn Gly Ile Asp Ile Tyr Val Glu 
    50                  55                  60                  


Tyr Thr Gly Thr Gly Leu Val Asp Ile Leu Gly 
65                  70                  75  


<210>  33
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33

Ser Thr Asp Pro Glu Gly Ala Tyr Glu Thr Val Lys Lys Glu Tyr Lys 
1               5                   10                  15      


Arg Lys Trp Asn Ile Val Trp Leu Lys Pro Leu Gly Phe Asn Asn Thr 
            20                  25                  30          


Tyr Thr Leu Ala Val Lys Asp Glu Leu Ala Lys Gln Tyr Asn Leu Lys 
        35                  40                  45              


Thr Phe Ser Asp Leu Ala Lys Ile Ser Asp Lys Leu Ile Leu Gly Ala 
    50                  55                  60                  


Thr Met Phe Phe Leu Glu Lys Pro Asp Gly Tyr Pro Gly Leu Gln Lys 
65                  70                  75                  80  


Leu Tyr Asn Phe Lys Phe Lys His Thr Lys Ser Met Asp Met Gly Ile 
                85                  90                  95      


Arg Tyr Thr Ala Ile Asp Asn Asn Glu Val Gln Val Ile Asp Ala Phe 
            100                 105                 110         


Ala Thr Asp Gly Leu Leu Val Ser His Lys Leu Lys Ile Leu Glu Asp 
        115                 120                 125             


Asp Lys His Phe Phe Pro Pro Tyr Tyr Ala Ala Pro Ile Ile Arg Gln 
    130                 135                 140                 


Asp Val Leu Asp Lys His Pro Glu Leu Lys Asp Val Leu Asn Lys Leu 
145                 150                 155                 160 


Ala Asn Gln Ile Ser Asp Glu Glu Met Gln Lys Leu Asn Tyr Lys Val 
                165                 170                 175     


Asp Gly Glu Gly Gln Asp Pro Ala Lys Val Ala Lys Glu Phe Leu Lys 
            180                 185                 190         


Glu Lys Gly Leu Ile Leu 
        195             


<210>  34
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34

Ala Asn Asp Thr Val Val Val Gly Ser Ile Asn Phe Thr Glu Gly Ile 
1               5                   10                  15      


Ile Val Ala Asn Met Val Ala Glu Met Ile Glu Ala His Thr Asp Leu 
            20                  25                  30          


Lys Val Val Arg Lys Leu Asn Leu Gly Gly Glu Asn Val Asn Phe Glu 
        35                  40                  45              


Ala Ile Lys Arg Gly Gly Ala Asn Asn Gly Ile Asp Ile Tyr Val Glu 
    50                  55                  60                  


Tyr Thr Gly His Gly Leu Val Asp Ile Leu Gly 
65                  70                  75  


<210>  35
<211>  197
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35

Ser Thr Asp Pro Glu Gly Ala Tyr Glu Thr Val Lys Lys Glu Tyr Lys 
1               5                   10                  15      


Arg Lys Trp Asn Ile Val Trp Leu Lys Pro Leu Gly Phe Asn Asn Thr 
            20                  25                  30          


Tyr Thr Leu Thr Val Lys Asp Glu Leu Ala Lys Gln Tyr Asn Leu Lys 
        35                  40                  45              


Thr Phe Ser Asp Leu Ala Lys Ile Ser Asp Lys Leu Ile Leu Gly Ala 
    50                  55                  60                  


Thr Met Phe Phe Leu Glu Gly Pro Asp Gly Tyr Pro Gly Leu Gln Lys 
65                  70                  75                  80  


Leu Tyr Asn Phe Lys Phe Lys His Thr Lys Ser Met Asp Met Gly Ile 
                85                  90                  95      


Arg Tyr Thr Ala Ile Asp Asn Asn Glu Val Gln Val Ile Asp Ala Trp 
            100                 105                 110         


Ala Thr Asp Gly Leu Leu Val Ser His Lys Leu Lys Ile Leu Glu Asp 
        115                 120                 125             


Asp Lys Ala Phe Phe Pro Pro Tyr Tyr Ala Ala Pro Ile Ile Arg Gln 
    130                 135                 140                 


Asp Val Leu Asp Lys His Pro Glu Leu Lys Asp Val Leu Asn Lys Leu 
145                 150                 155                 160 


Ala Asn Gln Ile Ser Leu Glu Glu Met Gln Lys Leu Asn Tyr Lys Val 
                165                 170                 175     


Asp Gly Glu Gly Gln Asp Pro Ala Lys Val Ala Lys Glu Phe Leu Lys 
            180                 185                 190         


Glu Lys Gly Leu Ile 
        195         


