                         SEQUENCE LISTING

<110>  BioArdis, LLC
 
<120>  EPCAM BINDING MOLECULES AND USES THEREOF

<130>  BWGB.007WO

<150>  US 63/127885
<151>  2020-12-18

<150>  US 63/262310
<151>  2021-10-08

<160>  52    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-A-B01 HCDR1

<400>  1

Gly Tyr Thr Phe Gly Ile Asp Phe 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-A-C01 HCDR1

<400>  2

Gly Phe Ile Ser Arg Leu Tyr His 
1               5               


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-A-E01 HCDR1

<400>  3

Gly Ser Ile Tyr Ser Val Asp Phe 
1               5               


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-A-B02 HCDR1

<400>  4

Gly Tyr Thr Phe Ser Ser Tyr Val 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-A-C02 HCDR1

<400>  5

Gly Ser Thr Tyr Asn Val Tyr Val 
1               5               


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-A-D02 HCDR1

<400>  6

Gly Gly Thr Phe Ser Tyr Asp Phe 
1               5               


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-A-A03 HCDR1

<400>  7

Gly Ser Ile Ser Asn Val Tyr Ile 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-A-B03 HCDR1

<400>  8

Gly Ser Thr Ser Ser Phe Asn Tyr 
1               5               


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-B-B01 HCDR1

<400>  9

Gly Phe Thr Phe Arg His Asp Val 
1               5               


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-B-D01 HCDR1

<400>  10

Gly Tyr Thr Phe Ser Phe Asp Phe 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-B-F01 HCDR1

<400>  11

Gly Ser Thr Phe Ser Phe Asn Phe 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-B-B02 HCDR1

<400>  12

Gly Arg Thr Phe Ser Tyr Asn Pro 
1               5               


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-B-F02 HCDR1

<400>  13

Gly Ser Ile Tyr Asn Phe Asp Tyr 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-A-B01 HCDR2

<400>  14

Ile Ser Arg Thr Gly Gly Ser Thr 
1               5               


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-A-C01 HCDR2

<400>  15

Ile Ser Arg Thr Gly Gly Ser Thr 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-A-E01 HCDR2

<400>  16

Ile Ser Arg Thr Gly Gly Ser Thr 
1               5               


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-A-B02 HCDR2

<400>  17

Ile Ser Arg Thr Gly Gly Ser Thr 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-A-C02 HCDR2

<400>  18

Ile Ser Arg Thr Gly Gly Ser Thr 
1               5               


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-A-D02 HCDR2

<400>  19

Ile Ser Arg Thr Gly Gly Ser Thr 
1               5               


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-A-A03 HCDR2

<400>  20

Ile Ser Arg Thr Gly Gly Ser Thr 
1               5               


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-A-B03 HCDR2

<400>  21

Ile Ser Arg Thr Gly Gly Ser Thr 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-B-B01 HCDR2

<400>  22

Ile Ser Arg Thr Gly Gly Ser Thr 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-B-D01 HCDR2

<400>  23

Ile Ser Arg Thr Gly Gly Ser Thr 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-B-F01 HCDR2

<400>  24

Ile Ser Arg Thr Gly Gly Ser Thr 
1               5               


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-B-B02 HCDR2

<400>  25

Ile Ser Arg Thr Gly Gly Ser Thr 
1               5               


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-B-F02 HCDR2

<400>  26

Ile Ser Arg Thr Gly Gly Ser Thr 
1               5               


<210>  27
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-A-B01 HCDR3

<400>  27

Ala Arg Gly Lys Thr Gln Leu Ala Trp Gln Gln Ala Pro Asp Ser Leu 
1               5                   10                  15      


Thr Val Phe Gly Tyr 
            20      


<210>  28
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-A-C01 HCDR3

<400>  28

Ala Thr Tyr Tyr Trp Pro Thr Glu Gly Asp Tyr Ser Tyr 
1               5                   10              


<210>  29
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-A-E01 HCDR3

<400>  29

Ala Arg Gln Phe Leu Asn His Pro Thr Ala Leu Gly Tyr 
1               5                   10              


<210>  30
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-A-B02 HCDR3

<400>  30

Ala Ala Gly Val Arg Ala Glu Asp Gly Arg Val Arg Thr Leu Pro Ser 
1               5                   10                  15      


Glu Tyr Thr Phe 
            20  


<210>  31
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-A-C02 HCDR3

<400>  31

Ala Arg Gln Leu Gly Ala Gln Gly Glu Pro Asn Val Ser Leu Gly Tyr 
1               5                   10                  15      


<210>  32
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-A-D02 HCDR3

<400>  32

Ala Arg Gln Lys Lys Gln Met Gly Arg Met Asp Gly Gln Ala Phe Gln 
1               5                   10                  15      


His Asp Tyr 
            


<210>  33
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-A-A03 HCDR3

<400>  33

Ala Arg Asp Glu Arg Thr Thr Arg Ile Gly Leu Gly Tyr 
1               5                   10              


<210>  34
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-A-B03 HCDR3

<400>  34

Val Arg Ala Asn Phe Leu Asn Ser His Ala Leu Gly Tyr 
1               5                   10              


<210>  35
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-B-B01 HCDR3

<400>  35

Ala Arg His Leu His Ala Pro Ser Val Gly Arg Ala Asp Gly Tyr Gly 
1               5                   10                  15      


His Gly Tyr 
            


<210>  36
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-B-D01 HCDR3

<400>  36

Ala Arg Leu Arg Gly Glu Phe Pro Asn Ala Phe Gly Tyr 
1               5                   10              


<210>  37
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-B-F01 HCDR3

<400>  37

Ala Arg Gln Lys Asp Gln Gly Gln Val Ile His Gly Tyr 
1               5                   10              


<210>  38
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-B-B02 HCDR3

<400>  38

Val Arg Thr Ser Val Asp Arg Val Thr Asn Ile Glu Pro Phe Ser Tyr 
1               5                   10                  15      


<210>  39
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-B-F02 HCDR3

<400>  39

Ala Arg Gln Ser Ala Arg Ala Asn Leu Ala Leu Gly Tyr 
1               5                   10              


<210>  40
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-A-B01 VH

<400>  40

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Gly Ile Asp 
            20                  25                  30          


Phe Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Gly Lys Thr Gln Leu Ala Trp Gln Gln Ala Pro Asp Ser 
            100                 105                 110         


Leu Thr Val Phe Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  41
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-A-C01 VH

<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Ser Arg Leu Tyr 
            20                  25                  30          


His Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Thr Tyr Tyr Trp Pro Thr Glu Gly Asp Tyr Ser Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  42
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-A-E01 VH

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Tyr Ser Val Asp 
            20                  25                  30          


Phe Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Gln Phe Leu Asn His Pro Thr Ala Leu Gly Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  43
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-A-B02 VH

<400>  43

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Arg Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Val Arg Ala Glu Asp Gly Arg Val Arg Thr Leu Pro 
            100                 105                 110         


Ser Glu Tyr Thr Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  44
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-A-C02 VH

<400>  44

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Tyr Asn Val Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Gln Leu Gly Ala Gln Gly Glu Pro Asn Val Ser Leu Gly 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  45
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-A-D02 VH

<400>  45

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Tyr Asp 
            20                  25                  30          


Phe Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Gln Lys Lys Gln Met Gly Arg Met Asp Gly Gln Ala Phe 
            100                 105                 110         


Gln His Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  46
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-A-A03 VH

<400>  46

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Asn Val Tyr 
            20                  25                  30          


Ile Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asp Glu Arg Thr Thr Arg Ile Gly Leu Gly Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  47
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-A-B03 VH

<400>  47

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Ser Ser Phe Asn 
            20                  25                  30          


Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Arg Ala Asn Phe Leu Asn Ser His Ala Leu Gly Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  48
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-B-B01 VH

<400>  48

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg His Asp 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg His Leu His Ala Pro Ser Val Gly Arg Ala Asp Gly Tyr 
            100                 105                 110         


Gly His Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  49
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-B-D01 VH

<400>  49

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser Phe Asp 
            20                  25                  30          


Phe Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Leu Arg Gly Glu Phe Pro Asn Ala Phe Gly Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  50
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-B-F01 VH

<400>  50

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser Phe Asn 
            20                  25                  30          


Phe Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Gln Lys Asp Gln Gly Gln Val Ile His Gly Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  51
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-B-B02 VH

<400>  51

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Tyr Asn 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Arg Thr Ser Val Asp Arg Val Thr Asn Ile Glu Pro Phe Ser 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  52
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM-B-F02 VH

<400>  52

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Tyr Asn Phe Asp 
            20                  25                  30          


Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Gln Ser Ala Arg Ala Asn Leu Ala Leu Gly Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


