                               SEQUENCE LISTING

<110> ARVADA THERAPEUTICS, INC.
 
<120> DSG2 COMPOSITIONS AND METHODS FOR THE TREATMENT OF COVID-19

<130> 2198.1001PCT

<140> PCT/US2021/XXXXXX
<141> 2021-12-15

<150> 63/274,715
<151> 2021-11-02

<150> 63/125,583
<151> 2020-12-15

<160> 16    

<170> PatentIn version 3.5

<210> 1
<211> 1118
<212> PRT
<213> Homo sapiens

<400> 1
Met Ala Arg Ser Pro Gly Arg Ala Tyr Ala Leu Leu Leu Leu Leu Ile 
1               5                   10                  15      


Cys Phe Asn Val Gly Ser Gly Leu His Leu Gln Val Leu Ser Thr Arg 
            20                  25                  30          


Asn Glu Asn Lys Leu Leu Pro Lys His Pro His Leu Val Arg Gln Lys 
        35                  40                  45              


Arg Ala Trp Ile Thr Ala Pro Val Ala Leu Arg Glu Gly Glu Asp Leu 
    50                  55                  60                  


Ser Lys Lys Asn Pro Ile Ala Lys Ile His Ser Asp Leu Ala Glu Glu 
65                  70                  75                  80  


Arg Gly Leu Lys Ile Thr Tyr Lys Tyr Thr Gly Lys Gly Ile Thr Glu 
                85                  90                  95      


Pro Pro Phe Gly Ile Phe Val Phe Asn Lys Asp Thr Gly Glu Leu Asn 
            100                 105                 110         


Val Thr Ser Ile Leu Asp Arg Glu Glu Thr Pro Phe Phe Leu Leu Thr 
        115                 120                 125             


Gly Tyr Ala Leu Asp Ala Arg Gly Asn Asn Val Glu Lys Pro Leu Glu 
    130                 135                 140                 


Leu Arg Ile Lys Val Leu Asp Ile Asn Asp Asn Glu Pro Val Phe Thr 
145                 150                 155                 160 


Gln Asp Val Phe Val Gly Ser Val Glu Glu Leu Ser Ala Ala His Thr 
                165                 170                 175     


Leu Val Met Lys Ile Asn Ala Thr Asp Ala Asp Glu Pro Asn Thr Leu 
            180                 185                 190         


Asn Ser Lys Ile Ser Tyr Arg Ile Val Ser Leu Glu Pro Ala Tyr Pro 
        195                 200                 205             


Pro Val Phe Tyr Leu Asn Lys Asp Thr Gly Glu Ile Tyr Thr Thr Ser 
    210                 215                 220                 


Val Thr Leu Asp Arg Glu Glu His Ser Ser Tyr Thr Leu Thr Val Glu 
225                 230                 235                 240 


Ala Arg Asp Gly Asn Gly Glu Val Thr Asp Lys Pro Val Lys Gln Ala 
                245                 250                 255     


Gln Val Gln Ile Arg Ile Leu Asp Val Asn Asp Asn Ile Pro Val Val 
            260                 265                 270         


Glu Asn Lys Val Leu Glu Gly Met Val Glu Glu Asn Gln Val Asn Val 
        275                 280                 285             


Glu Val Thr Arg Ile Lys Val Phe Asp Ala Asp Glu Ile Gly Ser Asp 
    290                 295                 300                 


Asn Trp Leu Ala Asn Phe Thr Phe Ala Ser Gly Asn Glu Gly Gly Tyr 
305                 310                 315                 320 


Phe His Ile Glu Thr Asp Ala Gln Thr Asn Glu Gly Ile Val Thr Leu 
                325                 330                 335     


Ile Lys Glu Val Asp Tyr Glu Glu Met Lys Asn Leu Asp Phe Ser Val 
            340                 345                 350         


Ile Val Ala Asn Lys Ala Ala Phe His Lys Ser Ile Arg Ser Lys Tyr 
        355                 360                 365             


Lys Pro Thr Pro Ile Pro Ile Lys Val Lys Val Lys Asn Val Lys Glu 
    370                 375                 380                 


Gly Ile His Phe Lys Ser Ser Val Ile Ser Ile Tyr Val Ser Glu Ser 
385                 390                 395                 400 


Met Asp Arg Ser Ser Lys Gly Gln Ile Ile Gly Asn Phe Gln Ala Phe 
                405                 410                 415     


Asp Glu Asp Thr Gly Leu Pro Ala His Ala Arg Tyr Val Lys Leu Glu 
            420                 425                 430         


Asp Arg Asp Asn Trp Ile Ser Val Asp Ser Val Thr Ser Glu Ile Lys 
        435                 440                 445             


Leu Ala Lys Leu Pro Asp Phe Glu Ser Arg Tyr Val Gln Asn Gly Thr 
    450                 455                 460                 


Tyr Thr Val Lys Ile Val Ala Ile Ser Glu Asp Tyr Pro Arg Lys Thr 
465                 470                 475                 480 


Ile Thr Gly Thr Val Leu Ile Asn Val Glu Asp Ile Asn Asp Asn Cys 
                485                 490                 495     


Pro Thr Leu Ile Glu Pro Val Gln Thr Ile Cys His Asp Ala Glu Tyr 
            500                 505                 510         


Val Asn Val Thr Ala Glu Asp Leu Asp Gly His Pro Asn Ser Gly Pro 
        515                 520                 525             


Phe Ser Phe Ser Val Ile Asp Lys Pro Pro Gly Met Ala Glu Lys Trp 
    530                 535                 540                 


Lys Ile Ala Arg Gln Glu Ser Thr Ser Val Leu Leu Gln Gln Ser Glu 
545                 550                 555                 560 


Lys Lys Leu Gly Arg Ser Glu Ile Gln Phe Leu Ile Ser Asp Asn Gln 
                565                 570                 575     


Gly Phe Ser Cys Pro Glu Lys Gln Val Leu Thr Leu Thr Val Cys Glu 
            580                 585                 590         


Cys Leu His Gly Ser Gly Cys Arg Glu Ala Gln His Asp Ser Tyr Val 
        595                 600                 605             


Gly Leu Gly Pro Ala Ala Ile Ala Leu Met Ile Leu Ala Phe Leu Leu 
    610                 615                 620                 


Leu Leu Leu Val Pro Leu Leu Leu Leu Met Cys His Cys Gly Lys Gly 
625                 630                 635                 640 


Ala Lys Gly Phe Thr Pro Ile Pro Gly Thr Ile Glu Met Leu His Pro 
                645                 650                 655     


Trp Asn Asn Glu Gly Ala Pro Pro Glu Asp Lys Val Val Pro Ser Phe 
            660                 665                 670         


Leu Pro Val Asp Gln Gly Gly Ser Leu Val Gly Arg Asn Gly Val Gly 
        675                 680                 685             


Gly Met Ala Lys Glu Ala Thr Met Lys Gly Ser Ser Ser Ala Ser Ile 
    690                 695                 700                 


Val Lys Gly Gln His Glu Met Ser Glu Met Asp Gly Arg Trp Glu Glu 
705                 710                 715                 720 


His Arg Ser Leu Leu Ser Gly Arg Ala Thr Gln Phe Thr Gly Ala Thr 
                725                 730                 735     


Gly Ala Ile Met Thr Thr Glu Thr Thr Lys Thr Ala Arg Ala Thr Gly 
            740                 745                 750         


Ala Ser Arg Asp Met Ala Gly Ala Gln Ala Ala Ala Val Ala Leu Asn 
        755                 760                 765             


Glu Glu Phe Leu Arg Asn Tyr Phe Thr Asp Lys Ala Ala Ser Tyr Thr 
    770                 775                 780                 


Glu Glu Asp Glu Asn His Thr Ala Lys Asp Cys Leu Leu Val Tyr Ser 
785                 790                 795                 800 


Gln Glu Glu Thr Glu Ser Leu Asn Ala Ser Ile Gly Cys Cys Ser Phe 
                805                 810                 815     


Ile Glu Gly Glu Leu Asp Asp Arg Phe Leu Asp Asp Leu Gly Leu Lys 
            820                 825                 830         


Phe Lys Thr Leu Ala Glu Val Cys Leu Gly Gln Lys Ile Asp Ile Asn 
        835                 840                 845             


Lys Glu Ile Glu Gln Arg Gln Lys Pro Ala Thr Glu Thr Ser Met Asn 
    850                 855                 860                 


Thr Ala Ser His Ser Leu Cys Glu Gln Thr Met Val Asn Ser Glu Asn 
865                 870                 875                 880 


Thr Tyr Ser Ser Gly Ser Ser Phe Pro Val Pro Lys Ser Leu Gln Glu 
                885                 890                 895     


Ala Asn Ala Glu Lys Val Thr Gln Glu Ile Val Thr Glu Arg Ser Val 
            900                 905                 910         


Ser Ser Arg Gln Ala Gln Lys Val Ala Thr Pro Leu Pro Asp Pro Met 
        915                 920                 925             


Ala Ser Arg Asn Val Ile Ala Thr Glu Thr Ser Tyr Val Thr Gly Ser 
    930                 935                 940                 


Thr Met Pro Pro Thr Thr Val Ile Leu Gly Pro Ser Gln Pro Gln Ser 
945                 950                 955                 960 


Leu Ile Val Thr Glu Arg Val Tyr Ala Pro Ala Ser Thr Leu Val Asp 
                965                 970                 975     


Gln Pro Tyr Ala Asn Glu Gly Thr Val Val Val Thr Glu Arg Val Ile 
            980                 985                 990         


Gln Pro His Gly Gly Gly Ser Asn  Pro Leu Glu Gly Thr  Gln His Leu 
        995                 1000                 1005             


Gln Asp  Val Pro Tyr Val Met  Val Arg Glu Arg Glu  Ser Phe Leu 
    1010                 1015                 1020             


Ala Pro  Ser Ser Gly Val Gln  Pro Thr Leu Ala Met  Pro Asn Ile 
    1025                 1030                 1035             


Ala Val  Gly Gln Asn Val Thr  Val Thr Glu Arg Val  Leu Ala Pro 
    1040                 1045                 1050             


Ala Ser  Thr Leu Gln Ser Ser  Tyr Gln Ile Pro Thr  Glu Asn Ser 
    1055                 1060                 1065             


Met Thr  Ala Arg Asn Thr Thr  Val Ser Gly Ala Gly  Val Pro Gly 
    1070                 1075                 1080             


Pro Leu  Pro Asp Phe Gly Leu  Glu Glu Ser Gly His  Ser Asn Ser 
    1085                 1090                 1095             


Thr Ile  Thr Thr Ser Ser Thr  Arg Val Thr Lys His  Ser Thr Val 
    1100                 1105                 1110             


Gln His  Ser Tyr Ser 
    1115             


<210> 2
<211> 5697
<212> DNA
<213> Homo sapiens

<400> 2
gaggagccga gtgcgcgctc ggggcaggcg gcggcgcgga gcggtgcggc ggcgggaggc       60

ggaggcgagg gtgcgatggc gcggagcccg ggacgcgcgt acgccctgct gcttctcctg      120

atctgcttta acgttggaag tggacttcac ttacaggtct taagcacaag aaatgaaaat      180

aagctgcttc ctaaacatcc tcatttagtg cggcaaaagc gcgcctggat caccgccccc      240

gtggctcttc gggagggaga ggatctgtcc aagaagaatc caattgccaa gatacattct      300

gatcttgcag aagaaagagg actcaaaatt acttacaaat acactggaaa agggattaca      360

gagccacctt ttggtatatt tgtctttaac aaagatactg gagaactgaa tgttaccagc      420

attcttgatc gagaagaaac accatttttt ctgctaacag gttacgcttt ggatgcaaga      480

ggaaacaatg tagagaaacc cttagagcta cgcattaagg ttcttgatat caatgacaac      540

gaaccagtgt tcacacagga tgtctttgtt gggtctgttg aagagttgag tgcagcacat      600

actcttgtga tgaaaatcaa tgcaacagat gcagatgagc ccaataccct gaattcgaaa      660

atttcctata gaatcgtatc tctggagcct gcttatcctc cagtgttcta cctaaataaa      720

gatacaggag agatttatac aaccagtgtt accttggaca gagaggaaca cagcagctac      780

actttgacag tagaagcaag agatggcaat ggagaagtta cagacaaacc tgtaaaacaa      840

gctcaagttc agattcgtat tttggatgtc aatgacaata tacctgtagt agaaaataaa      900

gtgcttgaag ggatggttga agaaaatcaa gtcaacgtag aagttacgcg cataaaagtg      960

ttcgatgcag atgaaatagg ttctgataat tggctggcaa attttacatt tgcatcagga     1020

aatgaaggag gttatttcca catagaaaca gatgctcaaa ctaacgaagg aattgtgacc     1080

cttattaagg aagtagatta tgaagaaatg aagaatcttg acttcagtgt tattgtcgct     1140

aataaagcag cttttcacaa gtcgattagg agtaaataca agcctacacc cattcccatc     1200

aaggtcaaag tgaaaaatgt gaaagaaggc attcatttta aaagcagcgt catctcaatt     1260

tatgttagcg agagcatgga tagatcaagc aaaggccaaa taattggaaa ttttcaagct     1320

tttgatgagg acactggact accagcccat gcaagatatg taaaattaga agatagagat     1380

aattggatct ctgtggattc tgtcacatct gaaattaaac ttgcaaaact tcctgatttt     1440

gaatctagat atgttcaaaa tggcacatac actgtaaaga ttgtggccat atcagaagat     1500

tatcctagaa aaaccatcac tggcacagtc cttatcaatg ttgaagacat caacgacaac     1560

tgtcccacac tgatagagcc tgtgcagaca atctgtcacg atgcagagta tgtgaatgtt     1620

actgcagagg acctggatgg acacccaaac agtggccctt tcagtttctc cgtcattgac     1680

aaaccacctg gcatggcaga aaaatggaaa atagcacgcc aagaaagtac cagtgtgctg     1740

ctgcaacaaa gtgagaaaaa gcttgggaga agtgaaattc agttcctgat ttcagacaat     1800

cagggtttta gttgtcctga aaagcaggtc cttacactca cagtttgtga gtgtctgcat     1860

ggcagcggct gcagggaagc acagcatgac tcctatgtgg gcctgggacc cgcagcaatt     1920

gcgctcatga ttttggcctt tctgctcctg ctattggtac cacttttact gctgatgtgc     1980

cattgcggaa agggcgccaa aggctttacc cccatacctg gcaccataga gatgctgcat     2040

ccttggaata atgaaggagc accacctgaa gacaaggtgg tgccatcatt tctgccagtg     2100

gatcaagggg gcagtctagt aggaagaaat ggagtaggag gtatggccaa ggaagccacg     2160

atgaaaggaa gtagctctgc ttccattgtc aaagggcaac atgagatgtc cgagatggat     2220

ggaaggtggg aagaacacag aagcctgctt tctggtagag ctacccagtt tacaggggcc     2280

acaggcgcta tcatgaccac tgaaaccacg aagaccgcaa gggccacagg ggcttccaga     2340

gacatggccg gagctcaggc agctgctgtt gcactgaacg aagaattctt aagaaattat     2400

ttcactgata aagcggcctc ttacactgag gaagatgaaa atcacacagc caaagattgc     2460

cttctggttt attctcagga agaaactgaa tcgctgaatg cttctattgg ttgttgcagt     2520

tttattgaag gagagctaga tgaccgcttc ttagatgatt tgggacttaa attcaagaca     2580

ctagctgaag tttgcctggg tcaaaaaata gatataaata aggaaattga gcagagacaa     2640

aaacctgcca cagaaacaag tatgaacaca gcttcacatt cactctgtga gcaaactatg     2700

gttaattcag agaataccta ctcctctggc agtagcttcc cagttccaaa atctttgcaa     2760

gaagccaatg cagagaaagt aactcaggaa atagtcactg aaagatctgt gtcttctagg     2820

caggcgcaaa aggtagctac acctcttcct gacccaatgg cttctagaaa tgtgatagca     2880

acagaaactt cctatgtcac agggtccact atgccaccaa ccactgtgat cctgggtcct     2940

agccagccac agagccttat tgtgacagag agggtgtatg ctccagcttc taccttggta     3000

gatcagcctt atgctaatga aggtacagtt gtggtcactg aaagagtaat acagcctcat     3060

gggggtggat cgaatcctct ggaaggcact cagcatcttc aagatgtacc ttacgtcatg     3120

gtgagggaaa gagagagctt ccttgccccc agctcaggtg tgcagcctac tctggccatg     3180

cctaatatag cagtaggaca gaatgtgaca gtgacagaaa gagttctagc acctgcttcc     3240

actctgcaat ccagttacca gattcccact gaaaattcta tgacggctag gaacaccacg     3300

gtgtctggag ctggagtccc tggccctctg ccagattttg gtttagagga atctggtcat     3360

tctaattcta ccataaccac atcttccacc agagttacca agcatagcac tgtacagcat     3420

tcttactcct aaacagcagt cagccacaaa ctgacccaga gtttaattag cagtgactaa     3480

tttcatgttt ccaatgtacc tgatttttca tgagccttac agacacacag agacacatac     3540

acattgatct taaaattttt ctcagtcact gatatgcaaa ggaccacact gtctctgctt     3600

ccaggagtat tttagaaatg ttccacaatt tactgaagac atagagatga tgctgctgct     3660

taggtgcctt ttagcaagct atgcaaacaa tcctgataaa acaagataca tagagagtca     3720

atctggcttc tgagaattta ccaagtgaac agagtaccta gttcatcagc cgtccagtaa     3780

agcaacccag gaaactgact gggtctcttt gcctaccgta ttaacattaa acattgatgt     3840

tctgtattct gtactttact gcacccagca gactttcaac aactcattga tccaaagata     3900

catgcacagt ctgagcacca gctatggtgc tcataacttc tttaagactt gaaccctttc     3960

aatctgtgtg attcattaaa ttggaccatt gatgataaga atacacattg tatgtttctg     4020

tgcacatgac agtgtgtgtg tgtgcacgta catactgtat agtcttaaaa atagcattat     4080

actggccagg ggtggtggct aacgcctgta atcccagcac tttgggaggc cgaggcgggt     4140

ggatcaactg tggtcaggag tttgagatca gccaggccaa cctggtgaaa ccccgtctct     4200

actaaaaata caaaaattag ctgggcgtga tggtgggcgc ctgtaatccc agctacttgg     4260

gaggctgagg caggagaatc acttgaaccc gggaggcgga ggttgcagtg agccgagatc     4320

gcaccattgc actccagtct gggcaacaga gtgagattcc gtctcaaaaa aaaaaagaaa     4380

aggaaaaaaa aatagcatta tacctcttcc ttgtctcaac cgccatgaaa attctgaaca     4440

ctccaaattc agttgaataa tccaaaacaa aatttataag tataaaataa ttttacttct     4500

tatagtaata gtatacttta aaaagcctca gggtatatta tcttctaaac agctacaatt     4560

cagtgcagct acattaacca actatgttct ctagttgaga acaactaggc ctatttcact     4620

gctgtgtagc ctcagtgcct aacatgggtg ccaaataaat attcgtagaa ttacactgaa     4680

ttgtaaaaac cattcgtttt tgtttacaat tgccaaaaat ctcaaaaggc cctgtattta     4740

tgtaattctt tgaaattatt attttatttt gatttctcag ttattgactg gctgggtgtg     4800

acttagtaca taagtactca atattataaa aacctcaaat aattgacttg attttacaca     4860

acatccttcc cttttctaca agttaatttt tttacaaatc atttgggtta tctcctaaat     4920

aggttatatt ttattgcttc tagaaacaat gtttcaaaat atatgtgcat tatcagtaat     4980

aatttgtata aatatttccc acaacaattt tcataatttt caaagactaa tttcttgact     5040

gaagatattt tgctagggaa gtgaaacttt aaaattttgt agattttaaa aaatattgtt     5100

gaatggtgtc atgcaaagga tttatatagt gtgctcccac taactgtaca gatcaggaca     5160

catattttta gacatctaag tctgtagctt aaatggaggt tactcttcca tcatctagaa     5220

ttgtttactt agtaattgtt gtttctttta ttattataga cttactatca gttttatttt     5280

gccaagtatg caacaggtat atcactagta tatgaaaatg taaatatcac ttgtgtactc     5340

aaacaaaagt tggtcttaag cttccacctt gagcagcctt ggaaacctaa cctgcctctt     5400

ttagcataat cacattttct aaatgatttt ctttgttcct gaaaaagtga tttgtattag     5460

ttttacattt gttttttgga agattatatt tgtatatgta tcatcataaa atatttaaat     5520

aaaaagtatc tttagagtga ccctttcccc atagattttt atttctctat tatattttac     5580

aaggaatata actcagtttg ttagggagag tgccttaaag gcaggtgttt cttggacttt     5640

gttatttaat tagatctgct tgcaataaaa aaagttgtcg gttatctaaa attcaaa        5697


<210> 3
<211> 560
<212> PRT
<213> Homo sapiens

<400> 3
Ala Trp Ile Thr Ala Pro Val Ala Leu Arg Glu Gly Glu Asp Leu Ser 
1               5                   10                  15      


Lys Lys Asn Pro Ile Ala Lys Ile His Ser Asp Leu Ala Glu Glu Arg 
            20                  25                  30          


Gly Leu Lys Ile Thr Tyr Lys Tyr Thr Gly Lys Gly Ile Thr Glu Pro 
        35                  40                  45              


Pro Phe Gly Ile Phe Val Phe Asn Lys Asp Thr Gly Glu Leu Asn Val 
    50                  55                  60                  


Thr Ser Ile Leu Asp Arg Glu Glu Thr Pro Phe Phe Leu Leu Thr Gly 
65                  70                  75                  80  


Tyr Ala Leu Asp Ala Arg Gly Asn Asn Val Glu Lys Pro Leu Glu Leu 
                85                  90                  95      


Arg Ile Lys Val Leu Asp Ile Asn Asp Asn Glu Pro Val Phe Thr Gln 
            100                 105                 110         


Asp Val Phe Val Gly Ser Val Glu Glu Leu Ser Ala Ala His Thr Leu 
        115                 120                 125             


Val Met Lys Ile Asn Ala Thr Asp Ala Asp Glu Pro Asn Thr Leu Asn 
    130                 135                 140                 


Ser Lys Ile Ser Tyr Arg Ile Val Ser Leu Glu Pro Ala Tyr Pro Pro 
145                 150                 155                 160 


Val Phe Tyr Leu Asn Lys Asp Thr Gly Glu Ile Tyr Thr Thr Ser Val 
                165                 170                 175     


Thr Leu Asp Arg Glu Glu His Ser Ser Tyr Thr Leu Thr Val Glu Ala 
            180                 185                 190         


Arg Asp Gly Asn Gly Glu Val Thr Asp Lys Pro Val Lys Gln Ala Gln 
        195                 200                 205             


Val Gln Ile Arg Ile Leu Asp Val Asn Asp Asn Ile Pro Val Val Glu 
    210                 215                 220                 


Asn Lys Val Leu Glu Gly Met Val Glu Glu Asn Gln Val Asn Val Glu 
225                 230                 235                 240 


Val Thr Arg Ile Lys Val Phe Asp Ala Asp Glu Ile Gly Ser Asp Asn 
                245                 250                 255     


Trp Leu Ala Asn Phe Thr Phe Ala Ser Gly Asn Glu Gly Gly Tyr Phe 
            260                 265                 270         


His Ile Glu Thr Asp Ala Gln Thr Asn Glu Gly Ile Val Thr Leu Ile 
        275                 280                 285             


Lys Glu Val Asp Tyr Glu Glu Met Lys Asn Leu Asp Phe Ser Val Ile 
    290                 295                 300                 


Val Ala Asn Lys Ala Ala Phe His Lys Ser Ile Arg Ser Lys Tyr Lys 
305                 310                 315                 320 


Pro Thr Pro Ile Pro Ile Lys Val Lys Val Lys Asn Val Lys Glu Gly 
                325                 330                 335     


Ile His Phe Lys Ser Ser Val Ile Ser Ile Tyr Val Ser Glu Ser Met 
            340                 345                 350         


Asp Arg Ser Ser Lys Gly Gln Ile Ile Gly Asn Phe Gln Ala Phe Asp 
        355                 360                 365             


Glu Asp Thr Gly Leu Pro Ala His Ala Arg Tyr Val Lys Leu Glu Asp 
    370                 375                 380                 


Arg Asp Asn Trp Ile Ser Val Asp Ser Val Thr Ser Glu Ile Lys Leu 
385                 390                 395                 400 


Ala Lys Leu Pro Asp Phe Glu Ser Arg Tyr Val Gln Asn Gly Thr Tyr 
                405                 410                 415     


Thr Val Lys Ile Val Ala Ile Ser Glu Asp Tyr Pro Arg Lys Thr Ile 
            420                 425                 430         


Thr Gly Thr Val Leu Ile Asn Val Glu Asp Ile Asn Asp Asn Cys Pro 
        435                 440                 445             


Thr Leu Ile Glu Pro Val Gln Thr Ile Cys His Asp Ala Glu Tyr Val 
    450                 455                 460                 


Asn Val Thr Ala Glu Asp Leu Asp Gly His Pro Asn Ser Gly Pro Phe 
465                 470                 475                 480 


Ser Phe Ser Val Ile Asp Lys Pro Pro Gly Met Ala Glu Lys Trp Lys 
                485                 490                 495     


Ile Ala Arg Gln Glu Ser Thr Ser Val Leu Leu Gln Gln Ser Glu Lys 
            500                 505                 510         


Lys Leu Gly Arg Ser Glu Ile Gln Phe Leu Ile Ser Asp Asn Gln Gly 
        515                 520                 525             


Phe Ser Cys Pro Glu Lys Gln Val Leu Thr Leu Thr Val Cys Glu Cys 
    530                 535                 540                 


Leu His Gly Ser Gly Cys Arg Glu Ala Gln His Asp Ser Tyr Val Gly 
545                 550                 555                 560 


<210> 4
<211> 330
<212> PRT
<213> Homo sapiens

<400> 4
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210> 5
<211> 227
<212> PRT
<213> Homo sapiens

<400> 5
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210> 6
<211> 326
<212> PRT
<213> Homo sapiens

<400> 6
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210> 7
<211> 228
<212> PRT
<213> Homo sapiens

<400> 7
Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
65                  70                  75                  80  


Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ser Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Pro Gly Lys 
225             


<210> 8
<211> 377
<212> PRT
<213> Homo sapiens

<400> 8
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                 105                 110         


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                 120                 125             


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                 135                 140                 


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375         


<210> 9
<211> 279
<212> PRT
<213> Homo sapiens

<400> 9
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
            20                  25                  30          


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
        35                  40                  45              


Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala Pro 
    50                  55                  60                  


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
65                  70                  75                  80  


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                85                  90                  95      


Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr Val Asp 
            100                 105                 110         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        115                 120                 125             


Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    130                 135                 140                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
145                 150                 155                 160 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg 
                165                 170                 175     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
            180                 185                 190         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        195                 200                 205             


Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn Tyr Asn 
    210                 215                 220                 


Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
225                 230                 235                 240 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile Phe Ser 
                245                 250                 255     


Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser 
            260                 265                 270         


Leu Ser Leu Ser Pro Gly Lys 
        275                 


<210> 10
<211> 327
<212> PRT
<213> Homo sapiens

<400> 10
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210> 11
<211> 229
<212> PRT
<213> Homo sapiens

<400> 11
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210> 12
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      linker sequence"

<400> 12
Gly Gly Gly Gly Ser 
1               5   


<210> 13
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      linker sequence"

<400> 13
Glu Ala Ala Ala Lys 
1               5   


<210> 14
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      linker sequence"

<400> 14
Gly Gly Gly Gly Gly Gly Gly Gly 
1               5               


<210> 15
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      linker sequence"


<220>
<221> SITE
<222> (1)..(25)
<223> /note="This sequence may encompass 2-5 'Glu Ala Ala Ala Lys'
      repeating units"

<400> 15
Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu 
1               5                   10                  15      


Ala Ala Ala Lys Glu Ala Ala Ala Lys 
            20                  25  


<210> 16
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      linker sequence"

<400> 16
Gly Gly Gly Gly Gly Ser 
1               5       


