                         SEQUENCE LISTING

<110>  EmendoBio Inc.
 
<120>  BIALLELIC KNOCKOUT OF B2M

<130>  91654-A-PCT/GJG/AWG

<150>  63/125,214
<151>  2020-12-14

<160>  1583  

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1
aaagagagag uagcgcgagc                                                   20


<210>  2
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  2
aaggccacgg agcgagacau                                                   20


<210>  3
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  3
agaaagagag aguagcgcga                                                   20


<210>  4
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  4
agagagagua gcgcgagcac                                                   20


<210>  5
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  5
agagaguagc gcgagcacag                                                   20


<210>  6
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  6
agaugucucg cuccguggcc                                                   20


<210>  7
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  7
agcacagcua aggccacgga                                                   20


<210>  8
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  8
agccuccagg ccagaaagag                                                   20


<210>  9
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  9
agcgcgagca cagcuaaggc                                                   20


<210>  10
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  10
agcuaaggcc acggagcgag                                                   20


<210>  11
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  11
aggccagaaa gagagaguag                                                   20


<210>  12
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  12
aguagcgcga gcacagcuaa                                                   20


<210>  13
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  13
auagccucca ggccagaaag                                                   20


<210>  14
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  14
augucucgcu ccguggccuu                                                   20


<210>  15
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  15
cagaaagaga gaguagcgcg                                                   20


<210>  16
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  16
cagcuaaggc cacggagcga                                                   20


<210>  17
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  17
ccaggccaga aagagagagu                                                   20


<210>  18
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  18
ccgagauguc ucgcuccgug                                                   20


<210>  19
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  19
ccuccaggcc agaaagagag                                                   20


<210>  20
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  20
ccuuagcugu gcucgcgcua                                                   20


<210>  21
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  21
cgagaugucu cgcuccgugg                                                   20


<210>  22
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  22
cgcgcuacuc ucucuuucug                                                   20


<210>  23
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  23
cgcuccgugg ccuuagcugu                                                   20


<210>  24
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  24
cgcuggauag ccuccaggcc                                                   20


<210>  25
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  25
cuaaggccac ggagcgagac                                                   20


<210>  26
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  26
cuacucucuc uuucuggccu                                                   20


<210>  27
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  27
cucacgcugg auagccucca                                                   20


<210>  28
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  28
cuccaggcca gaaagagaga                                                   20


<210>  29
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  29
cuccguggcc uuagcugugc                                                   20


<210>  30
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  30
cucuuucugg ccuggaggcu                                                   20


<210>  31
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  31
cuggauagcc uccaggccag                                                   20


<210>  32
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  32
cugugcucgc gcuacucucu                                                   20


<210>  33
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  33
cuuagcugug cucgcgcuac                                                   20


<210>  34
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  34
cuuucuggcc uggaggcuau                                                   20


<210>  35
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  35
gaaagagaga guagcgcgag                                                   20


<210>  36
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  36
gagagaguag cgcgagcaca                                                   20


<210>  37
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  37
gagaguagcg cgagcacagc                                                   20


<210>  38
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  38
gagaugucuc gcuccguggc                                                   20


<210>  39
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  39
gagcacagcu aaggccacgg                                                   20


<210>  40
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  40
gcacagcuaa ggccacggag                                                   20


<210>  41
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  41
gccagaaaga gagaguagcg                                                   20


<210>  42
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  42
gccgagaugu cucgcuccgu                                                   20


<210>  43
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  43
gccuuagcug ugcucgcgcu                                                   20


<210>  44
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  44
gcgagcacag cuaaggccac                                                   20


<210>  45
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  45
gcgcgagcac agcuaaggcc                                                   20


<210>  46
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  46
gcuaaggcca cggagcgaga                                                   20


<210>  47
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  47
gcuggauagc cuccaggcca                                                   20


<210>  48
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  48
ggauagccuc caggccagaa                                                   20


<210>  49
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  49
ggccuggagg cuauccagcg                                                   20


<210>  50
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  50
ggccuuagcu gugcucgcgc                                                   20


<210>  51
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  51
guagcgcgag cacagcuaag                                                   20


<210>  52
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  52
gucucgcucc guggccuuag                                                   20


<210>  53
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  53
guggccuuag cugugcucgc                                                   20


<210>  54
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  54
uaaggccacg gagcgagaca                                                   20


<210>  55
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  55
uagcgcgagc acagcuaagg                                                   20


<210>  56
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  56
uagcugugcu cgcgcuacuc                                                   20


<210>  57
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  57
ucacgcugga uagccuccag                                                   20


<210>  58
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  58
uccguggccu uagcugugcu                                                   20


<210>  59
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  59
ucgcgcuacu cucucuuucu                                                   20


<210>  60
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  60
ucgcuccgug gccuuagcug                                                   20


<210>  61
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  61
ucucgcuccg uggccuuagc                                                   20


<210>  62
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  62
uggccuuagc ugugcucgcg                                                   20


<210>  63
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  63
ugucucgcuc cguggccuua                                                   20


<210>  64
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  64
uucuggccug gaggcuaucc                                                   20


<210>  65
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  65
aaagagagag uagcgcgagc a                                                 21


<210>  66
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  66
aagagagagu agcgcgagca c                                                 21


<210>  67
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  67
aaggccacgg agcgagacau c                                                 21


<210>  68
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  68
acagcuaagg ccacggagcg a                                                 21


<210>  69
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  69
acgcuggaua gccuccaggc c                                                 21


<210>  70
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  70
acucacgcug gauagccucc a                                                 21


<210>  71
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  71
acucucucuu ucuggccugg a                                                 21


<210>  72
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  72
agaaagagag aguagcgcga g                                                 21


<210>  73
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  73
agagagagua gcgcgagcac a                                                 21


<210>  74
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  74
agagaguagc gcgagcacag c                                                 21


<210>  75
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  75
agaguagcgc gagcacagcu a                                                 21


<210>  76
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  76
agcacagcua aggccacgga g                                                 21


<210>  77
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  77
agccuccagg ccagaaagag a                                                 21


<210>  78
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  78
agcgcgagca cagcuaaggc c                                                 21


<210>  79
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  79
agcuaaggcc acggagcgag a                                                 21


<210>  80
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  80
aggccacgga gcgagacauc u                                                 21


<210>  81
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  81
aggccagaaa gagagaguag c                                                 21


<210>  82
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  82
aguagcgcga gcacagcuaa g                                                 21


<210>  83
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  83
augucucgcu ccguggccuu a                                                 21


<210>  84
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  84
cacagcuaag gccacggagc g                                                 21


<210>  85
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  85
cacgcuggau agccuccagg c                                                 21


<210>  86
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  86
cagaaagaga gaguagcgcg a                                                 21


<210>  87
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  87
cagcuaaggc cacggagcga g                                                 21


<210>  88
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  88
caggccagaa agagagagua g                                                 21


<210>  89
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  89
ccagaaagag agaguagcgc g                                                 21


<210>  90
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  90
ccaggccaga aagagagagu a                                                 21


<210>  91
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  91
ccgagauguc ucgcuccgug g                                                 21


<210>  92
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  92
ccguggccuu agcugugcuc g                                                 21


<210>  93
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  93
ccuccaggcc agaaagagag a                                                 21


<210>  94
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  94
ccuuagcugu gcucgcgcua c                                                 21


<210>  95
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  95
cgagaugucu cgcuccgugg c                                                 21


<210>  96
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  96
cgagcacagc uaaggccacg g                                                 21


<210>  97
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  97
cgcgagcaca gcuaaggcca c                                                 21


<210>  98
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  98
cgcuacucuc ucuuucuggc c                                                 21


<210>  99
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  99
cgcuccgugg ccuuagcugu g                                                 21


<210>  100
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  100
cgcuggauag ccuccaggcc a                                                 21


<210>  101
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  101
cguggccuua gcugugcucg c                                                 21


<210>  102
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  102
cuaaggccac ggagcgagac a                                                 21


<210>  103
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  103
cucgcuccgu ggccuuagcu g                                                 21


<210>  104
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  104
cucucuuucu ggccuggagg c                                                 21


<210>  105
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  105
cucuuucugg ccuggaggcu a                                                 21


<210>  106
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  106
cuggccugga ggcuauccag c                                                 21


<210>  107
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  107
cuuucuggcc uggaggcuau c                                                 21


<210>  108
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  108
gaaagagaga guagcgcgag c                                                 21


<210>  109
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  109
gagagaguag cgcgagcaca g                                                 21


<210>  110
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  110
gagaguagcg cgagcacagc u                                                 21


<210>  111
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  111
gagaugucuc gcuccguggc c                                                 21


<210>  112
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  112
gagcacagcu aaggccacgg a                                                 21


<210>  113
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  113
gaguagcgcg agcacagcua a                                                 21


<210>  114
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  114
gauagccucc aggccagaaa g                                                 21


<210>  115
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  115
gaugucucgc uccguggccu u                                                 21


<210>  116
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  116
gcacagcuaa ggccacggag c                                                 21


<210>  117
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  117
gccagaaaga gagaguagcg c                                                 21


<210>  118
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  118
gccgagaugu cucgcuccgu g                                                 21


<210>  119
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  119
gccuccaggc cagaaagaga g                                                 21


<210>  120
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  120
gccuuagcug ugcucgcgcu a                                                 21


<210>  121
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  121
gcgagcacag cuaaggccac g                                                 21


<210>  122
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  122
gcgcuacucu cucuuucugg c                                                 21


<210>  123
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  123
gcuaaggcca cggagcgaga c                                                 21


<210>  124
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  124
gcuacucucu cuuucuggcc u                                                 21


<210>  125
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  125
gcuccguggc cuuagcugug c                                                 21


<210>  126
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  126
gcuggauagc cuccaggcca g                                                 21


<210>  127
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  127
gcugugcucg cgcuacucuc u                                                 21


<210>  128
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  128
ggauagccuc caggccagaa a                                                 21


<210>  129
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  129
ggccagaaag agagaguagc g                                                 21


<210>  130
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  130
ggccgagaug ucucgcuccg u                                                 21


<210>  131
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  131
ggccuuagcu gugcucgcgc u                                                 21


<210>  132
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  132
gggccgagau gucucgcucc g                                                 21


<210>  133
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  133
gucucgcucc guggccuuag c                                                 21


<210>  134
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  134
gugcucgcgc uacucucucu u                                                 21


<210>  135
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  135
uaaggccacg gagcgagaca u                                                 21


<210>  136
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  136
uacucucucu uucuggccug g                                                 21


<210>  137
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  137
uagccuccag gccagaaaga g                                                 21


<210>  138
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  138
uagcgcgagc acagcuaagg c                                                 21


<210>  139
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  139
uagcugugcu cgcgcuacuc u                                                 21


<210>  140
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  140
ucacgcugga uagccuccag g                                                 21


<210>  141
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  141
uccaggccag aaagagagag u                                                 21


<210>  142
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  142
uccguggccu uagcugugcu c                                                 21


<210>  143
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  143
ucgcgcuacu cucucuuucu g                                                 21


<210>  144
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  144
ucgcuccgug gccuuagcug u                                                 21


<210>  145
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  145
ucucgcuccg uggccuuagc u                                                 21


<210>  146
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  146
ucucucuuuc uggccuggag g                                                 21


<210>  147
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  147
ucucuuucug gccuggaggc u                                                 21


<210>  148
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  148
ucuggccugg aggcuaucca g                                                 21


<210>  149
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  149
ucuuucuggc cuggaggcua u                                                 21


<210>  150
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  150
uggauagccu ccaggccaga a                                                 21


<210>  151
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  151
uggccuuagc ugugcucgcg c                                                 21


<210>  152
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  152
ugucucgcuc cguggccuua g                                                 21


<210>  153
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  153
uuagcugugc ucgcgcuacu c                                                 21


<210>  154
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  154
uucuggccug gaggcuaucc a                                                 21


<210>  155
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  155
uuucuggccu ggaggcuauc c                                                 21


<210>  156
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  156
aaagagagag uagcgcgagc ac                                                22


<210>  157
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  157
aagagagagu agcgcgagca ca                                                22


<210>  158
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  158
aaggccacgg agcgagacau cu                                                22


<210>  159
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  159
acagcuaagg ccacggagcg ag                                                22


<210>  160
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  160
acgcuggaua gccuccaggc ca                                                22


<210>  161
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  161
acucacgcug gauagccucc ag                                                22


<210>  162
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  162
acucucucuu ucuggccugg ag                                                22


<210>  163
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  163
agaaagagag aguagcgcga gc                                                22


<210>  164
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  164
agagagagua gcgcgagcac ag                                                22


<210>  165
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  165
agagaguagc gcgagcacag cu                                                22


<210>  166
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  166
agaguagcgc gagcacagcu aa                                                22


<210>  167
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  167
agaugucucg cuccguggcc uu                                                22


<210>  168
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  168
agcacagcua aggccacgga gc                                                22


<210>  169
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  169
agccuccagg ccagaaagag ag                                                22


<210>  170
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  170
agcgcgagca cagcuaaggc ca                                                22


<210>  171
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  171
agcuaaggcc acggagcgag ac                                                22


<210>  172
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  172
agcugugcuc gcgcuacucu cu                                                22


<210>  173
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  173
auagccucca ggccagaaag ag                                                22


<210>  174
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  174
cacagcuaag gccacggagc ga                                                22


<210>  175
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  175
cacgcuggau agccuccagg cc                                                22


<210>  176
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  176
cagaaagaga gaguagcgcg ag                                                22


<210>  177
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  177
cagcuaaggc cacggagcga ga                                                22


<210>  178
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  178
caggccagaa agagagagua gc                                                22


<210>  179
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  179
ccagaaagag agaguagcgc ga                                                22


<210>  180
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  180
ccaggccaga aagagagagu ag                                                22


<210>  181
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  181
ccgagauguc ucgcuccgug gc                                                22


<210>  182
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  182
ccuccaggcc agaaagagag ag                                                22


<210>  183
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  183
cgagaugucu cgcuccgugg cc                                                22


<210>  184
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  184
cgagcacagc uaaggccacg ga                                                22


<210>  185
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  185
cgcgagcaca gcuaaggcca cg                                                22


<210>  186
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  186
cgcgcuacuc ucucuuucug gc                                                22


<210>  187
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  187
cgcuacucuc ucuuucuggc cu                                                22


<210>  188
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  188
cgcuggauag ccuccaggcc ag                                                22


<210>  189
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  189
cguggccuua gcugugcucg cg                                                22


<210>  190
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  190
cuaaggccac ggagcgagac au                                                22


<210>  191
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  191
cuacucucuc uuucuggccu gg                                                22


<210>  192
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  192
cucacgcugg auagccucca gg                                                22


<210>  193
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  193
cuccaggcca gaaagagaga gu                                                22


<210>  194
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  194
cucgcuccgu ggccuuagcu gu                                                22


<210>  195
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  195
cucucucuuu cuggccugga gg                                                22


<210>  196
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  196
cucucuuucu ggccuggagg cu                                                22


<210>  197
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  197
cucuuucugg ccuggaggcu au                                                22


<210>  198
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  198
cuggauagcc uccaggccag aa                                                22


<210>  199
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  199
cuggccugga ggcuauccag cg                                                22


<210>  200
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  200
cugugcucgc gcuacucucu cu                                                22


<210>  201
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  201
cuuagcugug cucgcgcuac uc                                                22


<210>  202
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  202
cuuucuggcc uggaggcuau cc                                                22


<210>  203
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  203
gaaagagaga guagcgcgag ca                                                22


<210>  204
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  204
gacucacgcu ggauagccuc ca                                                22


<210>  205
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  205
gagagaguag cgcgagcaca gc                                                22


<210>  206
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  206
gagaguagcg cgagcacagc ua                                                22


<210>  207
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  207
gagaugucuc gcuccguggc cu                                                22


<210>  208
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  208
gagcacagcu aaggccacgg ag                                                22


<210>  209
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  209
gaguagcgcg agcacagcua ag                                                22


<210>  210
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  210
gauagccucc aggccagaaa ga                                                22


<210>  211
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  211
gaugucucgc uccguggccu ua                                                22


<210>  212
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  212
gcacagcuaa ggccacggag cg                                                22


<210>  213
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  213
gccagaaaga gagaguagcg cg                                                22


<210>  214
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  214
gccuccaggc cagaaagaga ga                                                22


<210>  215
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  215
gccuuagcug ugcucgcgcu ac                                                22


<210>  216
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  216
gcgagcacag cuaaggccac gg                                                22


<210>  217
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  217
gcgcgagcac agcuaaggcc ac                                                22


<210>  218
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  218
gcgcuacucu cucuuucugg cc                                                22


<210>  219
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  219
gcuaaggcca cggagcgaga ca                                                22


<210>  220
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  220
gcuacucucu cuuucuggcc ug                                                22


<210>  221
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  221
gcuccguggc cuuagcugug cu                                                22


<210>  222
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  222
gcucgcgcua cucucucuuu cu                                                22


<210>  223
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  223
gcuggauagc cuccaggcca ga                                                22


<210>  224
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  224
gcugugcucg cgcuacucuc uc                                                22


<210>  225
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  225
ggauagccuc caggccagaa ag                                                22


<210>  226
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  226
ggccagaaag agagaguagc gc                                                22


<210>  227
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  227
ggccgagaug ucucgcuccg ug                                                22


<210>  228
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  228
ggccuuagcu gugcucgcgc ua                                                22


<210>  229
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  229
gggccgagau gucucgcucc gu                                                22


<210>  230
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  230
guagcgcgag cacagcuaag gc                                                22


<210>  231
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  231
gucucgcucc guggccuuag cu                                                22


<210>  232
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  232
gugcucgcgc uacucucucu uu                                                22


<210>  233
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  233
guggccuuag cugugcucgc gc                                                22


<210>  234
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  234
uaaggccacg gagcgagaca uc                                                22


<210>  235
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  235
uacucucucu uucuggccug ga                                                22


<210>  236
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  236
uagccuccag gccagaaaga ga                                                22


<210>  237
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  237
uagcgcgagc acagcuaagg cc                                                22


<210>  238
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  238
uagcugugcu cgcgcuacuc uc                                                22


<210>  239
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  239
ucacgcugga uagccuccag gc                                                22


<210>  240
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  240
uccaggccag aaagagagag ua                                                22


<210>  241
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  241
uccguggccu uagcugugcu cg                                                22


<210>  242
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  242
ucgcgcuacu cucucuuucu gg                                                22


<210>  243
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  243
ucgcuccgug gccuuagcug ug                                                22


<210>  244
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  244
ucucucuuuc uggccuggag gc                                                22


<210>  245
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  245
ucucuuucug gccuggaggc ua                                                22


<210>  246
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  246
ucuggccugg aggcuaucca gc                                                22


<210>  247
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  247
uggauagccu ccaggccaga aa                                                22


<210>  248
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  248
uggccuuagc ugugcucgcg cu                                                22


<210>  249
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  249
ugucucgcuc cguggccuua gc                                                22


<210>  250
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  250
ugugcucgcg cuacucucuc uu                                                22


<210>  251
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  251
uuagcugugc ucgcgcuacu cu                                                22


<210>  252
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  252
uucuggccug gaggcuaucc ag                                                22


<210>  253
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  253
uuucuggccu ggaggcuauc ca                                                22


<210>  254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  254
aaaaguggag cauucagacu                                                   20


<210>  255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  255
aaacccagac acauagcaau                                                   20


<210>  256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  256
aaaccugaau cuuuggagua                                                   20


<210>  257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  257
aaagaccagu ccuugcugaa                                                   20


<210>  258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  258
aaagauucag guuuacucac                                                   20


<210>  259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  259
aaagucaaau uuccugaauu                                                   20


<210>  260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  260
aaagucacau gguucacacg                                                   20


<210>  261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  261
aaaguggagc auucagacuu                                                   20


<210>  262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  262
aaauuuccug aauugcuaug                                                   20


<210>  263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  263
aaauuugacu uuccauucuc                                                   20


<210>  264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  264
aaccauguga cuuugucaca                                                   20


<210>  265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  265
aaccugaauc uuuggaguac                                                   20


<210>  266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  266
aagacaaguc ugaaugcucc                                                   20


<210>  267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  267
aagaccaguc cuugcugaaa                                                   20


<210>  268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  268
aagagauaga aagaccaguc                                                   20


<210>  269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  269
aagauucagg uuuacucacg                                                   20


<210>  270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  270
aaggacuggu cuuucuaucu                                                   20


<210>  271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  271
aagucaaauu uccugaauug                                                   20


<210>  272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  272
aagucugaau gcuccacuuu                                                   20


<210>  273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  273
aaguggagca uucagacuug                                                   20


<210>  274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  274
aauggaaagu caaauuuccu                                                   20


<210>  275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  275
aauggagaga gaauugaaaa                                                   20


<210>  276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  276
aauucaggaa auuugacuuu                                                   20


<210>  277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  277
aauuuccuga auugcuaugu                                                   20


<210>  278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  278
aauuugacuu uccauucucu                                                   20


<210>  279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  279
acaagagaua gaaagaccag                                                   20


<210>  280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  280
acacauagca auucaggaaa                                                   20


<210>  281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  281
acauagcaau ucaggaaauu                                                   20


<210>  282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  282
acaugguuca cacggcaggc                                                   20


<210>  283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  283
accaugugac uuugucacag                                                   20


<210>  284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  284
accugaaucu uuggaguacc                                                   20


<210>  285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  285
acgugaguaa accugaaucu                                                   20


<210>  286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  286
acuacacuga auucaccccc                                                   20


<210>  287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  287
acuccaaaga uucagguuua                                                   20


<210>  288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  288
acugaaaaag augaguaugc                                                   20


<210>  289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  289
acuggucuuu cuaucucuug                                                   20


<210>  290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  290
acuuaacuau cuugggcugu                                                   20


<210>  291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  291
acuuacccca cuuaacuauc                                                   20


<210>  292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  292
acuucaaugu cggauggaug                                                   20


<210>  293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  293
acuuugucac agcccaagau                                                   20


<210>  294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  294
acuuuuucaa uucucucucc                                                   20


<210>  295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  295
agaaagacca guccuugcug                                                   20


<210>  296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  296
agaauggaga gagaauugaa                                                   20


<210>  297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  297
agaauugaaa aaguggagca                                                   20


<210>  298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  298
agacaagucu gaaugcucca                                                   20


<210>  299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  299
agacacauag caauucagga                                                   20


<210>  300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  300
agaccagucc uugcugaaag                                                   20


<210>  301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  301
agagaaugga aagucaaauu                                                   20


<210>  302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  302
agagaauuga aaaaguggag                                                   20


<210>  303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  303
agagagaauu gaaaaagugg                                                   20


<210>  304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  304
agagauagaa agaccagucc                                                   20


<210>  305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  305
agauagaaag accaguccuu                                                   20


<210>  306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  306
agauucaggu uuacucacgu                                                   20


<210>  307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  307
agcaauucag gaaauuugac                                                   20


<210>  308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  308
agcagagaau ggaaagucaa                                                   20


<210>  309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  309
agcauucaga cuugucuuuc                                                   20


<210>  310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  310
agcccaagau aguuaagugg                                                   20


<210>  311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  311
aggacugguc uuucuaucuc                                                   20


<210>  312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  312
aggcauacuc aucuuuuuca                                                   20


<210>  313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  313
aguaaaccug aaucuuugga                                                   20


<210>  314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  314
aguaugccug ccgugugaac                                                   20


<210>  315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  315
agucaaauuu ccugaauugc                                                   20


<210>  316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  316
agucaacuuc aaugucggau                                                   20


<210>  317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  317
aguccuugcu gaaagacaag                                                   20


<210>  318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  318
agucugaaug cuccacuuuu                                                   20


<210>  319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  319
aguggagcau ucagacuugu                                                   20


<210>  320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  320
auagaaagac caguccuugc                                                   20


<210>  321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  321
auagcaauuc aggaaauuug                                                   20


<210>  322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  322
auccagcaga gaauggaaag                                                   20


<210>  323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  323
auccgacauu gaaguugacu                                                   20


<210>  324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  324
aucucuugua cuacacugaa                                                   20


<210>  325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  325
aucuugggcu gugacaaagu                                                   20


<210>  326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  326
augaaaccca gacacauagc                                                   20


<210>  327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  327
augacgugag uaaaccugaa                                                   20


<210>  328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  328
augccugccg ugugaaccau                                                   20


<210>  329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  329
augcuccacu uuuucaauuc                                                   20


<210>  330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  330
auggaaaguc aaauuuccug                                                   20


<210>  331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  331
auggagagag aauugaaaaa                                                   20


<210>  332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  332
augguucaca cggcaggcau                                                   20


<210>  333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  333
augucggaug gaugaaaccc                                                   20


<210>  334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  334
augugucugg guuucaucca                                                   20


<210>  335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  335
auucaggaaa uuugacuuuc                                                   20


<210>  336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  336
auucagguuu acucacguca                                                   20


<210>  337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  337
auucucucuc cauucuucag                                                   20


<210>  338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  338
auucucugcu ggaugacgug                                                   20


<210>  339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  339
auucuucagu aagucaacuu                                                   20


<210>  340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  340
auugaaaaag uggagcauuc                                                   20


<210>  341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  341
auugaaguug acuuacugaa                                                   20


<210>  342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  342
auugcuaugu gucuggguuu                                                   20


<210>  343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  343
auuuccugaa uugcuaugug                                                   20


<210>  344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  344
caaagucaca ugguucacac                                                   20


<210>  345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  345
caaauuuccu gaauugcuau                                                   20


<210>  346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  346
caacuucaau gucggaugga                                                   20


<210>  347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  347
caagagauag aaagaccagu                                                   20


<210>  348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  348
caaggacugg ucuuucuauc                                                   20


<210>  349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  349
caagucugaa ugcuccacuu                                                   20


<210>  350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  350
caauucagga aauuugacuu                                                   20


<210>  351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  351
cacacggcag gcauacucau                                                   20


<210>  352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  352
cacauagcaa uucaggaaau                                                   20


<210>  353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  353
cacaugguuc acacggcagg                                                   20


<210>  354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  354
cacccccacu gaaaaagaug                                                   20


<210>  355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  355
cacggcaggc auacucaucu                                                   20


<210>  356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  356
cacgucaucc agcagagaau                                                   20


<210>  357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  357
cacugaaaaa gaugaguaug                                                   20


<210>  358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  358
cacuuaacua ucuugggcug                                                   20


<210>  359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  359
cagacacaua gcaauucagg                                                   20


<210>  360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  360
cagacuuguc uuucagcaag                                                   20


<210>  361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  361
cagagaaugg aaagucaaau                                                   20


<210>  362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  362
cagcagagaa uggaaaguca                                                   20


<210>  363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  363
caggaaauuu gacuuuccau                                                   20


<210>  364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  364
caggcauacu caucuuuuuc                                                   20


<210>  365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  365
cagguacucc aaagauucag                                                   20


<210>  366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  366
cagguuuacu cacgucaucc                                                   20


<210>  367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  367
caguccuugc ugaaagacaa                                                   20


<210>  368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  368
caguguagua caagagauag                                                   20


<210>  369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  369
cauagcaauu caggaaauuu                                                   20


<210>  370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  370
cauccagcag agaauggaaa                                                   20


<210>  371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  371
cauccgacau ugaaguugac                                                   20


<210>  372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  372
caucuuuuuc agugggggug                                                   20


<210>  373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  373
caugguucac acggcaggca                                                   20


<210>  374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  374
caugugacuu ugucacagcc                                                   20


<210>  375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  375
cauucagacu ugucuuucag                                                   20


<210>  376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  376
cauugaaguu gacuuacuga                                                   20


<210>  377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  377
ccaaagauuc agguuuacuc                                                   20


<210>  378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  378
ccacugaaaa agaugaguau                                                   20


<210>  379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  379
ccacuuaacu aucuugggcu                                                   20


<210>  380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  380
ccacuuuuuc aauucucucu                                                   20


<210>  381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  381
ccagacacau agcaauucag                                                   20


<210>  382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  382
ccaugugacu uugucacagc                                                   20


<210>  383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  383
ccauucuuca guaagucaac                                                   20


<210>  384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  384
cccaagauag uuaagugggg                                                   20


<210>  385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  385
cccacugaaa aagaugagua                                                   20


<210>  386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  386
cccacuuaac uaucuugggc                                                   20


<210>  387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  387
cccagacaca uagcaauuca                                                   20


<210>  388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  388
ccccacugaa aaagaugagu                                                   20


<210>  389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  389
ccgacauuga aguugacuua                                                   20


<210>  390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  390
ccugccgugu gaaccaugug                                                   20


<210>  391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  391
ccuugcugaa agacaagucu                                                   20


<210>  392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  392
cgacauugaa guugacuuac                                                   20


<210>  393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  393
cggauggaug aaacccagac                                                   20


<210>  394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  394
cgucauccag cagagaaugg                                                   20


<210>  395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  395
cgugugaacc augugacuuu                                                   20


<210>  396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  396
cuacacugaa uucaccccca                                                   20


<210>  397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  397
cuaucuuggg cugugacaaa                                                   20


<210>  398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  398
cucaucuuuu ucaguggggg                                                   20


<210>  399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  399
cuccaaagau ucagguuuac                                                   20


<210>  400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  400
cuccacuuuu ucaauucucu                                                   20


<210>  401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  401
cuccauucuu caguaaguca                                                   20


<210>  402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  402
cucuccauuc uucaguaagu                                                   20


<210>  403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  403
cucucuccau ucuucaguaa                                                   20


<210>  404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  404
cucugcugga ugacgugagu                                                   20


<210>  405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  405
cucuuguacu acacugaauu                                                   20


<210>  406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  406
cugaaugcuc cacuuuuuca                                                   20


<210>  407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  407
cugaauucac ccccacugaa                                                   20


<210>  408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  408
cugccgugug aaccauguga                                                   20


<210>  409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  409
cugcuggaug acgugaguaa                                                   20


<210>  410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  410
cuggguuuca uccauccgac                                                   20


<210>  411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  411
cuggucuuuc uaucucuugu                                                   20


<210>  412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  412
cugugacaaa gucacauggu                                                   20


<210>  413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  413
cuuaacuauc uugggcugug                                                   20


<210>  414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  414
cuuacugaag aauggagaga                                                   20


<210>  415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  415
cuucaauguc ggauggauga                                                   20


<210>  416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  416
cuucaguaag ucaacuucaa                                                   20


<210>  417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  417
cuugcugaaa gacaagucug                                                   20


<210>  418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  418
cuugggcugu gacaaaguca                                                   20


<210>  419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  419
cuuguacuac acugaauuca                                                   20


<210>  420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  420
cuugucuuuc agcaaggacu                                                   20


<210>  421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  421
cuuucagcaa ggacuggucu                                                   20


<210>  422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  422
cuuuccauuc ucugcuggau                                                   20


<210>  423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  423
cuuucuaucu cuuguacuac                                                   20


<210>  424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  424
cuuugucaca gcccaagaua                                                   20


<210>  425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  425
cuuuuucaau ucucucucca                                                   20


<210>  426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  426
cuuuuucagu gggggugaau                                                   20


<210>  427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  427
gaaaaagaug aguaugccug                                                   20


<210>  428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  428
gaaaaagugg agcauucaga                                                   20


<210>  429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  429
gaaacccaga cacauagcaa                                                   20


<210>  430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  430
gaaagacaag ucugaaugcu                                                   20


<210>  431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  431
gaaagucaaa uuuccugaau                                                   20


<210>  432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  432
gaaauuugac uuuccauucu                                                   20


<210>  433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  433
gaaccaugug acuuugucac                                                   20


<210>  434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  434
gaagaaugga gagagaauug                                                   20


<210>  435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  435
gaaugcucca cuuuuucaau                                                   20


<210>  436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  436
gaauggaaag ucaaauuucc                                                   20


<210>  437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  437
gaauucagug uaguacaaga                                                   20


<210>  438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  438
gaauugaaaa aguggagcau                                                   20


<210>  439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  439
gaauugcuau gugucugggu                                                   20


<210>  440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  440
gacaaaguca caugguucac                                                   20


<210>  441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  441
gacacauagc aauucaggaa                                                   20


<210>  442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  442
gaccaguccu ugcugaaaga                                                   20


<210>  443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  443
gacgugagua aaccugaauc                                                   20


<210>  444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  444
gacuggucuu ucuaucucuu                                                   20


<210>  445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  445
gacuuacccc acuuaacuau                                                   20


<210>  446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  446
gagaauggaa agucaaauuu                                                   20


<210>  447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  447
gagaauugaa aaaguggagc                                                   20


<210>  448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  448
gagagaauug aaaaagugga                                                   20


<210>  449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  449
gagauagaaa gaccaguccu                                                   20


<210>  450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  450
gaguaaaccu gaaucuuugg                                                   20


<210>  451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  451
gaguaugccu gccgugugaa                                                   20


<210>  452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  452
gauagaaaga ccaguccuug                                                   20


<210>  453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  453
gaugaaaccc agacacauag                                                   20


<210>  454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  454
gauucagguu uacucacguc                                                   20


<210>  455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  455
gcaaggacug gucuuucuau                                                   20


<210>  456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  456
gcaauucagg aaauuugacu                                                   20


<210>  457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  457
gcagagaaug gaaagucaaa                                                   20


<210>  458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  458
gcauucagac uugucuuuca                                                   20


<210>  459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  459
gcccaagaua guuaaguggg                                                   20


<210>  460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  460
gccgugugaa ccaugugacu                                                   20


<210>  461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  461
gcuauguguc uggguuucau                                                   20


<210>  462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  462
gcuccacuuu uucaauucuc                                                   20


<210>  463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  463
ggaaagucaa auuuccugaa                                                   20


<210>  464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  464
ggaaauuuga cuuuccauuc                                                   20


<210>  465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  465
ggacuggucu uucuaucucu                                                   20


<210>  466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  466
ggagagagaa uugaaaaagu                                                   20


<210>  467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  467
ggagcauuca gacuugucuu                                                   20


<210>  468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  468
ggaugaaacc cagacacaua                                                   20


<210>  469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  469
ggaugacgug aguaaaccug                                                   20


<210>  470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  470
ggauggauga aacccagaca                                                   20


<210>  471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  471
gggggugaau ucaguguagu                                                   20


<210>  472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  472
ggggugaauu caguguagua                                                   20


<210>  473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  473
ggguuucauc cauccgacau                                                   20


<210>  474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  474
gguacuccaa agauucaggu                                                   20


<210>  475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  475
ggucuuucua ucucuuguac                                                   20


<210>  476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  476
ggugaauuca guguaguaca                                                   20


<210>  477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  477
gguucacacg gcaggcauac                                                   20


<210>  478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  478
guaaaccuga aucuuuggag                                                   20


<210>  479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  479
guaagucaac uucaaugucg                                                   20


<210>  480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  480
guacaagaga uagaaagacc                                                   20


<210>  481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  481
guacuccaaa gauucagguu                                                   20


<210>  482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  482
guaguacaag agauagaaag                                                   20


<210>  483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  483
gucaaauuuc cugaauugcu                                                   20


<210>  484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  484
gucaacuuca augucggaug                                                   20


<210>  485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  485
gucacauggu ucacacggca                                                   20


<210>  486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  486
gucggaugga ugaaacccag                                                   20


<210>  487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  487
gucugaaugc uccacuuuuu                                                   20


<210>  488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  488
gugaaccaug ugacuuuguc                                                   20


<210>  489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  489
gugacaaagu cacaugguuc                                                   20


<210>  490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  490
gugacuuugu cacagcccaa                                                   20


<210>  491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  491
gugaguaaac cugaaucuuu                                                   20


<210>  492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  492
guggagcauu cagacuuguc                                                   20


<210>  493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  493
guguaguaca agagauagaa                                                   20


<210>  494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  494
gugugaacca ugugacuuug                                                   20


<210>  495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  495
guucacacgg caggcauacu                                                   20


<210>  496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  496
guugacuuac ugaagaaugg                                                   20


<210>  497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  497
uaaaccugaa ucuuuggagu                                                   20


<210>  498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  498
uaacuaucuu gggcugugac                                                   20


<210>  499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  499
uacaagagau agaaagacca                                                   20


<210>  500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  500
uacacugaau ucacccccac                                                   20


<210>  501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  501
uaccccacuu aacuaucuug                                                   20


<210>  502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  502
uacucacguc auccagcaga                                                   20


<210>  503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  503
uacucaucuu uuucaguggg                                                   20


<210>  504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  504
uacuccaaag auucagguuu                                                   20


<210>  505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  505
uacugaagaa uggagagaga                                                   20


<210>  506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  506
uagaaagacc aguccuugcu                                                   20


<210>  507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  507
uagcaauuca ggaaauuuga                                                   20


<210>  508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  508
uaguacaaga gauagaaaga                                                   20


<210>  509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  509
uaucuugggc ugugacaaag                                                   20


<210>  510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  510
uaugccugcc gugugaacca                                                   20


<210>  511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  511
uaugugucug gguuucaucc                                                   20


<210>  512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  512
ucaaauuucc ugaauugcua                                                   20


<210>  513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  513
ucaacuucaa ugucggaugg                                                   20


<210>  514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  514
ucacacggca ggcauacuca                                                   20


<210>  515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  515
ucagacuugu cuuucagcaa                                                   20


<210>  516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  516
ucaggaaauu ugacuuucca                                                   20


<210>  517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  517
ucagguacuc caaagauuca                                                   20


<210>  518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  518
ucaguguagu acaagagaua                                                   20


<210>  519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  519
ucauccagca gagaauggaa                                                   20


<210>  520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  520
ucauccaucc gacauugaag                                                   20


<210>  521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  521
ucaucuuuuu cagugggggu                                                   20


<210>  522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  522
uccaaagauu cagguuuacu                                                   20


<210>  523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  523
uccacuuuuu caauucucuc                                                   20


<210>  524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  524
uccagcagag aauggaaagu                                                   20


<210>  525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  525
uccauccgac auugaaguug                                                   20


<210>  526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  526
uccgacauug aaguugacuu                                                   20


<210>  527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  527
uccuugcuga aagacaaguc                                                   20


<210>  528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  528
ucggauggau gaaacccaga                                                   20


<210>  529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  529
ucucucucca uucuucagua                                                   20


<210>  530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  530
ucugaaugcu ccacuuuuuc                                                   20


<210>  531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  531
ucuggguuuc auccauccga                                                   20


<210>  532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  532
ucuucaguaa gucaacuuca                                                   20


<210>  533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  533
ucuuguacua cacugaauuc                                                   20


<210>  534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  534
ucuuucuauc ucuuguacua                                                   20


<210>  535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  535
ucuuuuucag ugggggugaa                                                   20


<210>  536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  536
ugaaaaagau gaguaugccu                                                   20


<210>  537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  537
ugaaaaagug gagcauucag                                                   20


<210>  538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  538
ugaaacccag acacauagca                                                   20


<210>  539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  539
ugaaagacaa gucugaaugc                                                   20


<210>  540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  540
ugaagaaugg agagagaauu                                                   20


<210>  541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  541
ugaaguugac uuacugaaga                                                   20


<210>  542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  542
ugaaugcucc acuuuuucaa                                                   20


<210>  543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  543
ugaauucagu guaguacaag                                                   20


<210>  544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  544
ugaauugcua ugugucuggg                                                   20


<210>  545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  545
ugacgugagu aaaccugaau                                                   20


<210>  546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  546
ugacuuucca uucucugcug                                                   20


<210>  547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  547
ugccguguga accaugugac                                                   20


<210>  548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  548
ugccugccgu gugaaccaug                                                   20


<210>  549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  549
ugcuaugugu cuggguuuca                                                   20


<210>  550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  550
ugcuccacuu uuucaauucu                                                   20


<210>  551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  551
ugcugaaaga caagucugaa                                                   20


<210>  552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  552
uggaaaguca aauuuccuga                                                   20


<210>  553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  553
uggagcauuc agacuugucu                                                   20


<210>  554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  554
uggaugaaac ccagacacau                                                   20


<210>  555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  555
uggaugacgu gaguaaaccu                                                   20


<210>  556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  556
ugggggugaa uucaguguag                                                   20


<210>  557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  557
uggguuucau ccauccgaca                                                   20


<210>  558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  558
uggucuuucu aucucuugua                                                   20


<210>  559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  559
ugguucacac ggcaggcaua                                                   20


<210>  560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  560
uguacuacac ugaauucacc                                                   20


<210>  561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  561
uguaguacaa gagauagaaa                                                   20


<210>  562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  562
ugucuggguu ucauccaucc                                                   20


<210>  563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  563
ugucuuucag caaggacugg                                                   20


<210>  564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  564
ugugaaccau gugacuuugu                                                   20


<210>  565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  565
ugugacaaag ucacaugguu                                                   20


<210>  566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  566
ugugacuuug ucacagccca                                                   20


<210>  567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  567
uuaacuaucu ugggcuguga                                                   20


<210>  568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  568
uuacucacgu cauccagcag                                                   20


<210>  569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  569
uuacugaaga auggagagag                                                   20


<210>  570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  570
uucacacggc aggcauacuc                                                   20


<210>  571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  571
uucaccccca cugaaaaaga                                                   20


<210>  572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  572
uucagcaagg acuggucuuu                                                   20


<210>  573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  573
uucaggaaau uugacuuucc                                                   20


<210>  574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  574
uucagguuua cucacgucau                                                   20


<210>  575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  575
uucaguguag uacaagagau                                                   20


<210>  576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  576
uucauccauc cgacauugaa                                                   20


<210>  577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  577
uuccauucuc ugcuggauga                                                   20


<210>  578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  578
uuccucaggu acuccaaaga                                                   20


<210>  579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  579
uucuaucucu uguacuacac                                                   20


<210>  580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  580
uucucugcug gaugacguga                                                   20


<210>  581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  581
uucuucagua agucaacuuc                                                   20


<210>  582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  582
uugaaaaagu ggagcauuca                                                   20


<210>  583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  583
uugaaguuga cuuacugaag                                                   20


<210>  584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  584
uugacuuucc auucucugcu                                                   20


<210>  585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  585
uugcuaugug ucuggguuuc                                                   20


<210>  586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  586
uugcugaaag acaagucuga                                                   20


<210>  587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  587
uugggcugug acaaagucac                                                   20


<210>  588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  588
uugucacagc ccaagauagu                                                   20


<210>  589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  589
uugucuuuca gcaaggacug                                                   20


<210>  590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  590
uuucagcaag gacuggucuu                                                   20


<210>  591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  591
uuuccauucu cugcuggaug                                                   20


<210>  592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  592
uuugucacag cccaagauag                                                   20


<210>  593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  593
uuuucaauuc ucucuccauu                                                   20


<210>  594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  594
uuuucagugg gggugaauuc                                                   20


<210>  595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  595
uuuuucaauu cucucuccau                                                   20


<210>  596
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  596
aaaaagauga guaugccugc c                                                 21


<210>  597
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  597
aaaagaugag uaugccugcc g                                                 21


<210>  598
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  598
aaaaguggag cauucagacu u                                                 21


<210>  599
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  599
aaacccagac acauagcaau u                                                 21


<210>  600
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  600
aaaccugaau cuuuggagua c                                                 21


<210>  601
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  601
aaagacaagu cugaaugcuc c                                                 21


<210>  602
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  602
aaagaccagu ccuugcugaa a                                                 21


<210>  603
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  603
aaagaugagu augccugccg u                                                 21


<210>  604
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  604
aaagauucag guuuacucac g                                                 21


<210>  605
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  605
aaagucacau gguucacacg g                                                 21


<210>  606
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  606
aaaguggagc auucagacuu g                                                 21


<210>  607
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  607
aaauuuccug aauugcuaug u                                                 21


<210>  608
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  608
aaauuugacu uuccauucuc u                                                 21


<210>  609
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  609
aacccagaca cauagcaauu c                                                 21


<210>  610
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  610
aaccugaauc uuuggaguac c                                                 21


<210>  611
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  611
aacuaucuug ggcugugaca a                                                 21


<210>  612
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  612
aacuucaaug ucggauggau g                                                 21


<210>  613
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  613
aagaauggag agagaauuga a                                                 21


<210>  614
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  614
aagacaaguc ugaaugcucc a                                                 21


<210>  615
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  615
aagaccaguc cuugcugaaa g                                                 21


<210>  616
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  616
aagagauaga aagaccaguc c                                                 21


<210>  617
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  617
aagauucagg uuuacucacg u                                                 21


<210>  618
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  618
aaggacuggu cuuucuaucu c                                                 21


<210>  619
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  619
aagucaaauu uccugaauug c                                                 21


<210>  620
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  620
aagucaacuu caaugucgga u                                                 21


<210>  621
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  621
aagucacaug guucacacgg c                                                 21


<210>  622
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  622
aagucugaau gcuccacuuu u                                                 21


<210>  623
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  623
aaguggagca uucagacuug u                                                 21


<210>  624
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  624
aaguugacuu acugaagaau g                                                 21


<210>  625
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  625
aaugcuccac uuuuucaauu c                                                 21


<210>  626
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  626
aauggaaagu caaauuuccu g                                                 21


<210>  627
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  627
aauggagaga gaauugaaaa a                                                 21


<210>  628
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  628
aaugucggau ggaugaaacc c                                                 21


<210>  629
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  629
aauucacccc cacugaaaaa g                                                 21


<210>  630
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  630
aauugaaaaa guggagcauu c                                                 21


<210>  631
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  631
aauugcuaug ugucuggguu u                                                 21


<210>  632
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  632
aauuuccuga auugcuaugu g                                                 21


<210>  633
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  633
aauuugacuu uccauucucu g                                                 21


<210>  634
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  634
acaaagucac augguucaca c                                                 21


<210>  635
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  635
acaagagaua gaaagaccag u                                                 21


<210>  636
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  636
acaagucuga augcuccacu u                                                 21


<210>  637
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  637
acacauagca auucaggaaa u                                                 21


<210>  638
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  638
acacggcagg cauacucauc u                                                 21


<210>  639
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  639
acacugaauu cacccccacu g                                                 21


<210>  640
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  640
acagcccaag auaguuaagu g                                                 21


<210>  641
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  641
acaugguuca cacggcaggc a                                                 21


<210>  642
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  642
acauugaagu ugacuuacug a                                                 21


<210>  643
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  643
accaguccuu gcugaaagac a                                                 21


<210>  644
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  644
accaugugac uuugucacag c                                                 21


<210>  645
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  645
acccagacac auagcaauuc a                                                 21


<210>  646
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  646
accccacuua acuaucuugg g                                                 21


<210>  647
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  647
acccccacug aaaaagauga g                                                 21


<210>  648
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  648
accugaaucu uuggaguacc u                                                 21


<210>  649
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  649
acggcaggca uacucaucuu u                                                 21


<210>  650
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  650
acgucaucca gcagagaaug g                                                 21


<210>  651
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  651
acuacacuga auucaccccc a                                                 21


<210>  652
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  652
acuaucuugg gcugugacaa a                                                 21


<210>  653
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  653
acucacguca uccagcagag a                                                 21


<210>  654
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  654
acucaucuuu uucagugggg g                                                 21


<210>  655
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  655
acuccaaaga uucagguuua c                                                 21


<210>  656
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  656
acugaaaaag augaguaugc c                                                 21


<210>  657
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  657
acugaagaau ggagagagaa u                                                 21


<210>  658
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  658
acugaauuca cccccacuga a                                                 21


<210>  659
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  659
acuggucuuu cuaucucuug u                                                 21


<210>  660
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  660
acuuaacuau cuugggcugu g                                                 21


<210>  661
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  661
acuuacccca cuuaacuauc u                                                 21


<210>  662
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  662
acuuacugaa gaauggagag a                                                 21


<210>  663
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  663
acuucaaugu cggauggaug a                                                 21


<210>  664
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  664
acuugucuuu cagcaaggac u                                                 21


<210>  665
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  665
acuuugucac agcccaagau a                                                 21


<210>  666
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  666
acuuuuucaa uucucucucc a                                                 21


<210>  667
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  667
agaaagacca guccuugcug a                                                 21


<210>  668
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  668
agaauggaga gagaauugaa a                                                 21


<210>  669
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  669
agaauugaaa aaguggagca u                                                 21


<210>  670
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  670
agacaagucu gaaugcucca c                                                 21


<210>  671
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  671
agacacauag caauucagga a                                                 21


<210>  672
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  672
agaccagucc uugcugaaag a                                                 21


<210>  673
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  673
agacuugucu uucagcaagg a                                                 21


<210>  674
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  674
agagaaugga aagucaaauu u                                                 21


<210>  675
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  675
agagaauuga aaaaguggag c                                                 21


<210>  676
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  676
agagagaauu gaaaaagugg a                                                 21


<210>  677
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  677
agagauagaa agaccagucc u                                                 21


<210>  678
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  678
agauagaaag accaguccuu g                                                 21


<210>  679
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  679
agaugaguau gccugccgug u                                                 21


<210>  680
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  680
agauucaggu uuacucacgu c                                                 21


<210>  681
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  681
agcaauucag gaaauuugac u                                                 21


<210>  682
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  682
agcauucaga cuugucuuuc a                                                 21


<210>  683
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  683
agcccaagau aguuaagugg g                                                 21


<210>  684
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  684
aggaaauuug acuuuccauu c                                                 21


<210>  685
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  685
aggcauacuc aucuuuuuca g                                                 21


<210>  686
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  686
agguacucca aagauucagg u                                                 21


<210>  687
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  687
agguuuacuc acgucaucca g                                                 21


<210>  688
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  688
aguaaaccug aaucuuugga g                                                 21


<210>  689
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  689
aguaagucaa cuucaauguc g                                                 21


<210>  690
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  690
aguacaagag auagaaagac c                                                 21


<210>  691
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  691
aguaugccug ccgugugaac c                                                 21


<210>  692
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  692
agucaaauuu ccugaauugc u                                                 21


<210>  693
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  693
agucaacuuc aaugucggau g                                                 21


<210>  694
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  694
agucacaugg uucacacggc a                                                 21


<210>  695
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  695
aguccuugcu gaaagacaag u                                                 21


<210>  696
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  696
aguggagcau ucagacuugu c                                                 21


<210>  697
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  697
aguguaguac aagagauaga a                                                 21


<210>  698
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  698
aguugacuua cugaagaaug g                                                 21


<210>  699
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  699
auagaaagac caguccuugc u                                                 21


<210>  700
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  700
auccagcaga gaauggaaag u                                                 21


<210>  701
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  701
aucucuugua cuacacugaa u                                                 21


<210>  702
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  702
aucuugggcu gugacaaagu c                                                 21


<210>  703
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  703
aucuuuuuca guggggguga a                                                 21


<210>  704
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  704
augaaaccca gacacauagc a                                                 21


<210>  705
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  705
augccugccg ugugaaccau g                                                 21


<210>  706
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  706
auggaaaguc aaauuuccug a                                                 21


<210>  707
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  707
auggaugaaa cccagacaca u                                                 21


<210>  708
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  708
augguucaca cggcaggcau a                                                 21


<210>  709
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  709
augucggaug gaugaaaccc a                                                 21


<210>  710
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  710
auucagacuu gucuuucagc a                                                 21


<210>  711
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  711
auucaggaaa uuugacuuuc c                                                 21


<210>  712
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  712
auucagguuu acucacguca u                                                 21


<210>  713
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  713
auucucucuc cauucuucag u                                                 21


<210>  714
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  714
auugaaaaag uggagcauuc a                                                 21


<210>  715
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  715
auugaaguug acuuacugaa g                                                 21


<210>  716
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  716
auugcuaugu gucuggguuu c                                                 21


<210>  717
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  717
auuuccugaa uugcuaugug u                                                 21


<210>  718
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  718
auuugacuuu ccauucucug c                                                 21


<210>  719
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  719
caaagauuca gguuuacuca c                                                 21


<210>  720
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  720
caaagucaca ugguucacac g                                                 21


<210>  721
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  721
caaauuuccu gaauugcuau g                                                 21


<210>  722
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  722
caacuucaau gucggaugga u                                                 21


<210>  723
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  723
caagagauag aaagaccagu c                                                 21


<210>  724
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  724
caaggacugg ucuuucuauc u                                                 21


<210>  725
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  725
caagucugaa ugcuccacuu u                                                 21


<210>  726
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  726
caaugucgga uggaugaaac c                                                 21


<210>  727
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  727
caauucagga aauuugacuu u                                                 21


<210>  728
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  728
cacagcccaa gauaguuaag u                                                 21


<210>  729
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  729
cacauagcaa uucaggaaau u                                                 21


<210>  730
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  730
cacaugguuc acacggcagg c                                                 21


<210>  731
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  731
cacggcaggc auacucaucu u                                                 21


<210>  732
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  732
cacgucaucc agcagagaau g                                                 21


<210>  733
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  733
cacugaaaaa gaugaguaug c                                                 21


<210>  734
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  734
cacuuaacua ucuugggcug u                                                 21


<210>  735
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  735
cacuuuuuca auucucucuc c                                                 21


<210>  736
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  736
cagacacaua gcaauucagg a                                                 21


<210>  737
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  737
cagacuuguc uuucagcaag g                                                 21


<210>  738
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  738
cagagaaugg aaagucaaau u                                                 21


<210>  739
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  739
cagcaaggac uggucuuucu a                                                 21


<210>  740
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  740
cagcccaaga uaguuaagug g                                                 21


<210>  741
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  741
caggaaauuu gacuuuccau u                                                 21


<210>  742
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  742
caggcauacu caucuuuuuc a                                                 21


<210>  743
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  743
cagguacucc aaagauucag g                                                 21


<210>  744
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  744
caguaaguca acuucaaugu c                                                 21


<210>  745
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  745
caguccuugc ugaaagacaa g                                                 21


<210>  746
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  746
caguguagua caagagauag a                                                 21


<210>  747
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  747
cauacucauc uuuuucagug g                                                 21


<210>  748
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  748
cauagcaauu caggaaauuu g                                                 21


<210>  749
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  749
cauccagcag agaauggaaa g                                                 21


<210>  750
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  750
cauccauccg acauugaagu u                                                 21


<210>  751
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  751
cauccgacau ugaaguugac u                                                 21


<210>  752
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  752
caucuuuuuc agugggggug a                                                 21


<210>  753
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  753
caugguucac acggcaggca u                                                 21


<210>  754
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  754
caugugacuu ugucacagcc c                                                 21


<210>  755
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  755
cauucagacu ugucuuucag c                                                 21


<210>  756
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  756
cauucuucag uaagucaacu u                                                 21


<210>  757
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  757
cauugaaguu gacuuacuga a                                                 21


<210>  758
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  758
ccaaagauuc agguuuacuc a                                                 21


<210>  759
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  759
ccacugaaaa agaugaguau g                                                 21


<210>  760
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  760
ccacuuaacu aucuugggcu g                                                 21


<210>  761
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  761
ccacuuuuuc aauucucucu c                                                 21


<210>  762
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  762
ccagacacau agcaauucag g                                                 21


<210>  763
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  763
ccagcagaga auggaaaguc a                                                 21


<210>  764
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  764
ccaguccuug cugaaagaca a                                                 21


<210>  765
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  765
ccauccgaca uugaaguuga c                                                 21


<210>  766
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  766
ccaugugacu uugucacagc c                                                 21


<210>  767
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  767
ccauucucug cuggaugacg u                                                 21


<210>  768
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  768
ccauucuuca guaagucaac u                                                 21


<210>  769
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  769
cccacugaaa aagaugagua u                                                 21


<210>  770
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  770
cccacuuaac uaucuugggc u                                                 21


<210>  771
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  771
cccagacaca uagcaauuca g                                                 21


<210>  772
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  772
ccccacugaa aaagaugagu a                                                 21


<210>  773
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  773
ccccacuuaa cuaucuuggg c                                                 21


<210>  774
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  774
cccccacuga aaaagaugag u                                                 21


<210>  775
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  775
ccgacauuga aguugacuua c                                                 21


<210>  776
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  776
ccgugugaac caugugacuu u                                                 21


<210>  777
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  777
ccucagguac uccaaagauu c                                                 21


<210>  778
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  778
ccugaauugc uaugugucug g                                                 21


<210>  779
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  779
ccugccgugu gaaccaugug a                                                 21


<210>  780
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  780
ccuugcugaa agacaagucu g                                                 21


<210>  781
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  781
cgacauugaa guugacuuac u                                                 21


<210>  782
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  782
cgucauccag cagagaaugg a                                                 21


<210>  783
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  783
cgugaguaaa ccugaaucuu u                                                 21


<210>  784
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  784
cgugugaacc augugacuuu g                                                 21


<210>  785
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  785
cucaucuuuu ucaguggggg u                                                 21


<210>  786
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  786
cuccacuuuu ucaauucucu c                                                 21


<210>  787
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  787
cucuccauuc uucaguaagu c                                                 21


<210>  788
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  788
cucucuccau ucuucaguaa g                                                 21


<210>  789
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  789
cucuuguacu acacugaauu c                                                 21


<210>  790
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  790
cugaaagaca agucugaaug c                                                 21


<210>  791
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  791
cugaagaaug gagagagaau u                                                 21


<210>  792
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  792
cugaaugcuc cacuuuuuca a                                                 21


<210>  793
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  793
cugaauucac ccccacugaa a                                                 21


<210>  794
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  794
cugccgugug aaccauguga c                                                 21


<210>  795
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  795
cuggaugacg ugaguaaacc u                                                 21


<210>  796
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  796
cuuaacuauc uugggcugug a                                                 21


<210>  797
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  797
cuuaccccac uuaacuaucu u                                                 21


<210>  798
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  798
cuuacugaag aauggagaga g                                                 21


<210>  799
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  799
cuucaauguc ggauggauga a                                                 21


<210>  800
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  800
cuucaguaag ucaacuucaa u                                                 21


<210>  801
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  801
cuugggcugu gacaaaguca c                                                 21


<210>  802
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  802
cuuguacuac acugaauuca c                                                 21


<210>  803
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  803
cuuuccauuc ucugcuggau g                                                 21


<210>  804
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  804
cuuucuaucu cuuguacuac a                                                 21


<210>  805
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  805
cuuuuucagu gggggugaau u                                                 21


<210>  806
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  806
gaaaaagaug aguaugccug c                                                 21


<210>  807
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  807
gaaaaagugg agcauucaga c                                                 21


<210>  808
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  808
gaaacccaga cacauagcaa u                                                 21


<210>  809
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  809
gaaagacaag ucugaaugcu c                                                 21


<210>  810
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  810
gaaagaccag uccuugcuga a                                                 21


<210>  811
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  811
gaaagucaaa uuuccugaau u                                                 21


<210>  812
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  812
gaaauuugac uuuccauucu c                                                 21


<210>  813
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  813
gaaccaugug acuuugucac a                                                 21


<210>  814
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  814
gaagaaugga gagagaauug a                                                 21


<210>  815
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  815
gaaguugacu uacugaagaa u                                                 21


<210>  816
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  816
gaaugcucca cuuuuucaau u                                                 21


<210>  817
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  817
gaauggaaag ucaaauuucc u                                                 21


<210>  818
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  818
gaauggagag agaauugaaa a                                                 21


<210>  819
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  819
gaauucaccc ccacugaaaa a                                                 21


<210>  820
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  820
gaauucagug uaguacaaga g                                                 21


<210>  821
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  821
gaauugaaaa aguggagcau u                                                 21


<210>  822
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  822
gaauugcuau gugucugggu u                                                 21


<210>  823
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  823
gacaagucug aaugcuccac u                                                 21


<210>  824
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  824
gacacauagc aauucaggaa a                                                 21


<210>  825
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  825
gacauugaag uugacuuacu g                                                 21


<210>  826
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  826
gaccaguccu ugcugaaaga c                                                 21


<210>  827
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  827
gacgugagua aaccugaauc u                                                 21


<210>  828
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  828
gacuggucuu ucuaucucuu g                                                 21


<210>  829
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  829
gacuuacccc acuuaacuau c                                                 21


<210>  830
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  830
gacuuacuga agaauggaga g                                                 21


<210>  831
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  831
gacuuuccau ucucugcugg a                                                 21


<210>  832
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  832
gacuuuguca cagcccaaga u                                                 21


<210>  833
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  833
gagaauggaa agucaaauuu c                                                 21


<210>  834
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  834
gagaauugaa aaaguggagc a                                                 21


<210>  835
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  835
gagagaauug aaaaagugga g                                                 21


<210>  836
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  836
gagagagaau ugaaaaagug g                                                 21


<210>  837
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  837
gagauagaaa gaccaguccu u                                                 21


<210>  838
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  838
gagcauucag acuugucuuu c                                                 21


<210>  839
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  839
gaguaaaccu gaaucuuugg a                                                 21


<210>  840
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  840
gaguaugccu gccgugugaa c                                                 21


<210>  841
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  841
gauagaaaga ccaguccuug c                                                 21


<210>  842
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  842
gaugaaaccc agacacauag c                                                 21


<210>  843
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  843
gaugacguga guaaaccuga a                                                 21


<210>  844
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  844
gauggaugaa acccagacac a                                                 21


<210>  845
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  845
gauucagguu uacucacguc a                                                 21


<210>  846
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  846
gcaauucagg aaauuugacu u                                                 21


<210>  847
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  847
gcagagaaug gaaagucaaa u                                                 21


<210>  848
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  848
gcaggcauac ucaucuuuuu c                                                 21


<210>  849
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  849
gcauucagac uugucuuuca g                                                 21


<210>  850
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  850
gcccaagaua guuaaguggg g                                                 21


<210>  851
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  851
gccgugugaa ccaugugacu u                                                 21


<210>  852
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  852
gccugccgug ugaaccaugu g                                                 21


<210>  853
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  853
gcuauguguc uggguuucau c                                                 21


<210>  854
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  854
gcuccacuuu uucaauucuc u                                                 21


<210>  855
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  855
gcugaaagac aagucugaau g                                                 21


<210>  856
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  856
gcugugacaa agucacaugg u                                                 21


<210>  857
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  857
ggaaagucaa auuuccugaa u                                                 21


<210>  858
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  858
ggaaauuuga cuuuccauuc u                                                 21


<210>  859
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  859
ggacuggucu uucuaucucu u                                                 21


<210>  860
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  860
ggagagagaa uugaaaaagu g                                                 21


<210>  861
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  861
ggagcauuca gacuugucuu u                                                 21


<210>  862
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  862
ggaugaaacc cagacacaua g                                                 21


<210>  863
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  863
ggaugacgug aguaaaccug a                                                 21


<210>  864
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  864
ggauggauga aacccagaca c                                                 21


<210>  865
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  865
ggcaggcaua cucaucuuuu u                                                 21


<210>  866
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  866
ggcauacuca ucuuuuucag u                                                 21


<210>  867
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  867
gggcugugac aaagucacau g                                                 21


<210>  868
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  868
gggggugaau ucaguguagu a                                                 21


<210>  869
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  869
ggggugaauu caguguagua c                                                 21


<210>  870
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  870
gggugaauuc aguguaguac a                                                 21


<210>  871
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  871
ggguuucauc cauccgacau u                                                 21


<210>  872
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  872
gguacuccaa agauucaggu u                                                 21


<210>  873
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  873
ggucuuucua ucucuuguac u                                                 21


<210>  874
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  874
ggugaauuca guguaguaca a                                                 21


<210>  875
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  875
gguucacacg gcaggcauac u                                                 21


<210>  876
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  876
gguuuacuca cgucauccag c                                                 21


<210>  877
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  877
gguuucaucc auccgacauu g                                                 21


<210>  878
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  878
guaaaccuga aucuuuggag u                                                 21


<210>  879
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  879
guaagucaac uucaaugucg g                                                 21


<210>  880
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  880
guacaagaga uagaaagacc a                                                 21


<210>  881
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  881
guacuacacu gaauucaccc c                                                 21


<210>  882
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  882
guaguacaag agauagaaag a                                                 21


<210>  883
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  883
gucaaauuuc cugaauugcu a                                                 21


<210>  884
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  884
gucacagccc aagauaguua a                                                 21


<210>  885
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  885
gucauccagc agagaaugga a                                                 21


<210>  886
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  886
guccuugcug aaagacaagu c                                                 21


<210>  887
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  887
gucggaugga ugaaacccag a                                                 21


<210>  888
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  888
gucuuucagc aaggacuggu c                                                 21


<210>  889
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  889
gucuuucuau cucuuguacu a                                                 21


<210>  890
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  890
gugaaccaug ugacuuuguc a                                                 21


<210>  891
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  891
gugacaaagu cacaugguuc a                                                 21


<210>  892
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  892
gugacuuugu cacagcccaa g                                                 21


<210>  893
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  893
guggagcauu cagacuuguc u                                                 21


<210>  894
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  894
guggggguga auucagugua g                                                 21


<210>  895
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  895
gugucugggu uucauccauc c                                                 21


<210>  896
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  896
guucacacgg caggcauacu c                                                 21


<210>  897
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  897
guuuacucac gucauccagc a                                                 21


<210>  898
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  898
guuucaucca uccgacauug a                                                 21


<210>  899
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  899
uaaaccugaa ucuuuggagu a                                                 21


<210>  900
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  900
uaacuaucuu gggcugugac a                                                 21


<210>  901
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  901
uaagucaacu ucaaugucgg a                                                 21


<210>  902
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  902
uacaagagau agaaagacca g                                                 21


<210>  903
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  903
uacacugaau ucacccccac u                                                 21


<210>  904
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  904
uaccccacuu aacuaucuug g                                                 21


<210>  905
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  905
uacuacacug aauucacccc c                                                 21


<210>  906
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  906
uacucacguc auccagcaga g                                                 21


<210>  907
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  907
uacucaucuu uuucaguggg g                                                 21


<210>  908
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  908
uacuccaaag auucagguuu a                                                 21


<210>  909
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  909
uacugaagaa uggagagaga a                                                 21


<210>  910
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  910
uagcaauuca ggaaauuuga c                                                 21


<210>  911
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  911
uaguacaaga gauagaaaga c                                                 21


<210>  912
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  912
uaugugucug gguuucaucc a                                                 21


<210>  913
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  913
ucaaauuucc ugaauugcua u                                                 21


<210>  914
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  914
ucaacuucaa ugucggaugg a                                                 21


<210>  915
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  915
ucaaugucgg auggaugaaa c                                                 21


<210>  916
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  916
ucacacggca ggcauacuca u                                                 21


<210>  917
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  917
ucacccccac ugaaaaagau g                                                 21


<210>  918
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  918
ucacgucauc cagcagagaa u                                                 21


<210>  919
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  919
ucagacuugu cuuucagcaa g                                                 21


<210>  920
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  920
ucagcaagga cuggucuuuc u                                                 21


<210>  921
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  921
ucaggaaauu ugacuuucca u                                                 21


<210>  922
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  922
ucagguacuc caaagauuca g                                                 21


<210>  923
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  923
ucaguaaguc aacuucaaug u                                                 21


<210>  924
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  924
ucaguguagu acaagagaua g                                                 21


<210>  925
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  925
ucauccagca gagaauggaa a                                                 21


<210>  926
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  926
ucauccaucc gacauugaag u                                                 21


<210>  927
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  927
ucaucuuuuu cagugggggu g                                                 21


<210>  928
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  928
uccaaagauu cagguuuacu c                                                 21


<210>  929
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  929
uccacuuuuu caauucucuc u                                                 21


<210>  930
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  930
uccagcagag aauggaaagu c                                                 21


<210>  931
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  931
uccauccgac auugaaguug a                                                 21


<210>  932
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  932
uccauucuuc aguaagucaa c                                                 21


<210>  933
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  933
uccucaggua cuccaaagau u                                                 21


<210>  934
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  934
uccugaauug cuaugugucu g                                                 21


<210>  935
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  935
uccuugcuga aagacaaguc u                                                 21


<210>  936
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  936
ucggauggau gaaacccaga c                                                 21


<210>  937
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  937
ucuaucucuu guacuacacu g                                                 21


<210>  938
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  938
ucuccauucu ucaguaaguc a                                                 21


<210>  939
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  939
ucucuccauu cuucaguaag u                                                 21


<210>  940
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  940
ucucucucca uucuucagua a                                                 21


<210>  941
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  941
ucucugcugg augacgugag u                                                 21


<210>  942
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  942
ucucuuguac uacacugaau u                                                 21


<210>  943
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  943
ucugaaugcu ccacuuuuuc a                                                 21


<210>  944
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  944
ucugcuggau gacgugagua a                                                 21


<210>  945
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  945
ucuggguuuc auccauccga c                                                 21


<210>  946
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  946
ucuucaguaa gucaacuuca a                                                 21


<210>  947
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  947
ucuugggcug ugacaaaguc a                                                 21


<210>  948
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  948
ucuuguacua cacugaauuc a                                                 21


<210>  949
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  949
ucuuucagca aggacugguc u                                                 21


<210>  950
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  950
ucuuucuauc ucuuguacua c                                                 21


<210>  951
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  951
ucuuuuucag ugggggugaa u                                                 21


<210>  952
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  952
ugaaaaagau gaguaugccu g                                                 21


<210>  953
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  953
ugaaaaagug gagcauucag a                                                 21


<210>  954
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  954
ugaaacccag acacauagca a                                                 21


<210>  955
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  955
ugaaagacaa gucugaaugc u                                                 21


<210>  956
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  956
ugaaccaugu gacuuuguca c                                                 21


<210>  957
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  957
ugaagaaugg agagagaauu g                                                 21


<210>  958
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  958
ugaaguugac uuacugaaga a                                                 21


<210>  959
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  959
ugaaugcucc acuuuuucaa u                                                 21


<210>  960
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  960
ugaauucacc cccacugaaa a                                                 21


<210>  961
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  961
ugaauucagu guaguacaag a                                                 21


<210>  962
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  962
ugacaaaguc acaugguuca c                                                 21


<210>  963
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  963
ugacgugagu aaaccugaau c                                                 21


<210>  964
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  964
ugacuuacug aagaauggag a                                                 21


<210>  965
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  965
ugacuuucca uucucugcug g                                                 21


<210>  966
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  966
ugacuuuguc acagcccaag a                                                 21


<210>  967
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  967
ugaguaaacc ugaaucuuug g                                                 21


<210>  968
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  968
ugaguaugcc ugccguguga a                                                 21


<210>  969
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  969
ugccguguga accaugugac u                                                 21


<210>  970
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  970
ugcuaugugu cuggguuuca u                                                 21


<210>  971
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  971
ugcuccacuu uuucaauucu c                                                 21


<210>  972
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  972
ugcugaaaga caagucugaa u                                                 21


<210>  973
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  973
ugcuggauga cgugaguaaa c                                                 21


<210>  974
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  974
uggaaaguca aauuuccuga a                                                 21


<210>  975
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  975
uggagagaga auugaaaaag u                                                 21


<210>  976
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  976
uggagcauuc agacuugucu u                                                 21


<210>  977
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  977
uggaugaaac ccagacacau a                                                 21


<210>  978
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  978
ugggcuguga caaagucaca u                                                 21


<210>  979
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  979
ugggggugaa uucaguguag u                                                 21


<210>  980
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  980
uggguuucau ccauccgaca u                                                 21


<210>  981
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  981
uggucuuucu aucucuugua c                                                 21


<210>  982
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  982
ugguucacac ggcaggcaua c                                                 21


<210>  983
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  983
uguacuacac ugaauucacc c                                                 21


<210>  984
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  984
uguaguacaa gagauagaaa g                                                 21


<210>  985
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  985
ugucacagcc caagauaguu a                                                 21


<210>  986
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  986
ugucggaugg augaaaccca g                                                 21


<210>  987
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  987
ugucuggguu ucauccaucc g                                                 21


<210>  988
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  988
ugucuuucag caaggacugg u                                                 21


<210>  989
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  989
ugugaaccau gugacuuugu c                                                 21


<210>  990
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  990
ugugacaaag ucacaugguu c                                                 21


<210>  991
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  991
ugugacuuug ucacagccca a                                                 21


<210>  992
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  992
ugugucuggg uuucauccau c                                                 21


<210>  993
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  993
uuacucacgu cauccagcag a                                                 21


<210>  994
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  994
uuacugaaga auggagagag a                                                 21


<210>  995
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  995
uucaaugucg gauggaugaa a                                                 21


<210>  996
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  996
uucaccccca cugaaaaaga u                                                 21


<210>  997
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  997
uucagcaagg acuggucuuu c                                                 21


<210>  998
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  998
uucaggaaau uugacuuucc a                                                 21


<210>  999
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  999
uucagguuua cucacgucau c                                                 21


<210>  1000
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1000
uucaguaagu caacuucaau g                                                 21


<210>  1001
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1001
uucagugggg gugaauucag u                                                 21


<210>  1002
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1002
uucaguguag uacaagagau a                                                 21


<210>  1003
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1003
uucauccauc cgacauugaa g                                                 21


<210>  1004
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1004
uuccauucuc ugcuggauga c                                                 21


<210>  1005
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1005
uucuaucucu uguacuacac u                                                 21


<210>  1006
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1006
uucucugcug gaugacguga g                                                 21


<210>  1007
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1007
uugaaaaagu ggagcauuca g                                                 21


<210>  1008
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1008
uugacuuacu gaagaaugga g                                                 21


<210>  1009
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1009
uugcuaugug ucuggguuuc a                                                 21


<210>  1010
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1010
uugcugaaag acaagucuga a                                                 21


<210>  1011
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1011
uugggcugug acaaagucac a                                                 21


<210>  1012
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1012
uuguacuaca cugaauucac c                                                 21


<210>  1013
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1013
uugucacagc ccaagauagu u                                                 21


<210>  1014
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1014
uugucuuuca gcaaggacug g                                                 21


<210>  1015
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1015
uuuacucacg ucauccagca g                                                 21


<210>  1016
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1016
uuucaauucu cucuccauuc u                                                 21


<210>  1017
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1017
uuucagcaag gacuggucuu u                                                 21


<210>  1018
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1018
uuucaguggg ggugaauuca g                                                 21


<210>  1019
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1019
uuuccugaau ugcuaugugu c                                                 21


<210>  1020
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1020
uuugacuuuc cauucucugc u                                                 21


<210>  1021
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1021
uuugucacag cccaagauag u                                                 21


<210>  1022
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1022
uuuucaauuc ucucuccauu c                                                 21


<210>  1023
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1023
uuuucagugg gggugaauuc a                                                 21


<210>  1024
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1024
uuuuucaauu cucucuccau u                                                 21


<210>  1025
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1025
aaaaagauga guaugccugc cg                                                22


<210>  1026
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1026
aaaaagugga gcauucagac uu                                                22


<210>  1027
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1027
aaaagaugag uaugccugcc gu                                                22


<210>  1028
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1028
aaaaguggag cauucagacu ug                                                22


<210>  1029
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1029
aaacccagac acauagcaau uc                                                22


<210>  1030
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1030
aaaccugaau cuuuggagua cc                                                22


<210>  1031
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1031
aaagacaagu cugaaugcuc ca                                                22


<210>  1032
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1032
aaagaccagu ccuugcugaa ag                                                22


<210>  1033
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1033
aaagaugagu augccugccg ug                                                22


<210>  1034
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1034
aaagauucag guuuacucac gu                                                22


<210>  1035
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1035
aaagucaaau uuccugaauu gc                                                22


<210>  1036
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1036
aaagucacau gguucacacg gc                                                22


<210>  1037
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1037
aaaguggagc auucagacuu gu                                                22


<210>  1038
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1038
aaauuuccug aauugcuaug ug                                                22


<210>  1039
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1039
aaauuugacu uuccauucuc ug                                                22


<210>  1040
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1040
aaccauguga cuuugucaca gc                                                22


<210>  1041
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1041
aacccagaca cauagcaauu ca                                                22


<210>  1042
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1042
aaccugaauc uuuggaguac cu                                                22


<210>  1043
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1043
aacuaucuug ggcugugaca aa                                                22


<210>  1044
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1044
aacuucaaug ucggauggau ga                                                22


<210>  1045
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1045
aagaauggag agagaauuga aa                                                22


<210>  1046
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1046
aagaccaguc cuugcugaaa ga                                                22


<210>  1047
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1047
aagagauaga aagaccaguc cu                                                22


<210>  1048
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1048
aagaugagua ugccugccgu gu                                                22


<210>  1049
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1049
aagauucagg uuuacucacg uc                                                22


<210>  1050
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1050
aaggacuggu cuuucuaucu cu                                                22


<210>  1051
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1051
aagucaaauu uccugaauug cu                                                22


<210>  1052
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1052
aagucaacuu caaugucgga ug                                                22


<210>  1053
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1053
aagucacaug guucacacgg ca                                                22


<210>  1054
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1054
aagucugaau gcuccacuuu uu                                                22


<210>  1055
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1055
aaguggagca uucagacuug uc                                                22


<210>  1056
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1056
aaguugacuu acugaagaau gg                                                22


<210>  1057
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1057
aaugcuccac uuuuucaauu cu                                                22


<210>  1058
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1058
aauggaaagu caaauuuccu ga                                                22


<210>  1059
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1059
aauggagaga gaauugaaaa ag                                                22


<210>  1060
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1060
aaugucggau ggaugaaacc ca                                                22


<210>  1061
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1061
aauucacccc cacugaaaaa ga                                                22


<210>  1062
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1062
aauucaggaa auuugacuuu cc                                                22


<210>  1063
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1063
aauucagugu aguacaagag au                                                22


<210>  1064
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1064
aauugaaaaa guggagcauu ca                                                22


<210>  1065
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1065
aauugcuaug ugucuggguu uc                                                22


<210>  1066
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1066
aauuuccuga auugcuaugu gu                                                22


<210>  1067
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1067
aauuugacuu uccauucucu gc                                                22


<210>  1068
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1068
acaaagucac augguucaca cg                                                22


<210>  1069
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1069
acaagagaua gaaagaccag uc                                                22


<210>  1070
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1070
acaagucuga augcuccacu uu                                                22


<210>  1071
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1071
acacauagca auucaggaaa uu                                                22


<210>  1072
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1072
acacggcagg cauacucauc uu                                                22


<210>  1073
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1073
acacugaauu cacccccacu ga                                                22


<210>  1074
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1074
acagcccaag auaguuaagu gg                                                22


<210>  1075
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1075
acauagcaau ucaggaaauu ug                                                22


<210>  1076
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1076
acaugguuca cacggcaggc au                                                22


<210>  1077
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1077
acauugaagu ugacuuacug aa                                                22


<210>  1078
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1078
accaguccuu gcugaaagac aa                                                22


<210>  1079
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1079
accaugugac uuugucacag cc                                                22


<210>  1080
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1080
acccagacac auagcaauuc ag                                                22


<210>  1081
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1081
accccacuua acuaucuugg gc                                                22


<210>  1082
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1082
acccccacug aaaaagauga gu                                                22


<210>  1083
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1083
acggcaggca uacucaucuu uu                                                22


<210>  1084
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1084
acgugaguaa accugaaucu uu                                                22


<210>  1085
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1085
acuacacuga auucaccccc ac                                                22


<210>  1086
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1086
acuaucuugg gcugugacaa ag                                                22


<210>  1087
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1087
acucacguca uccagcagag aa                                                22


<210>  1088
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1088
acucaucuuu uucagugggg gu                                                22


<210>  1089
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1089
acuccaaaga uucagguuua cu                                                22


<210>  1090
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1090
acugaaaaag augaguaugc cu                                                22


<210>  1091
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1091
acugaagaau ggagagagaa uu                                                22


<210>  1092
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1092
acugaauuca cccccacuga aa                                                22


<210>  1093
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1093
acuggucuuu cuaucucuug ua                                                22


<210>  1094
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1094
acuuaacuau cuugggcugu ga                                                22


<210>  1095
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1095
acuuacccca cuuaacuauc uu                                                22


<210>  1096
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1096
acuuacugaa gaauggagag ag                                                22


<210>  1097
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1097
acuucaaugu cggauggaug aa                                                22


<210>  1098
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1098
acuugucuuu cagcaaggac ug                                                22


<210>  1099
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1099
acuuugucac agcccaagau ag                                                22


<210>  1100
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1100
acuuuuucaa uucucucucc au                                                22


<210>  1101
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1101
agaaagacca guccuugcug aa                                                22


<210>  1102
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1102
agaauggaaa gucaaauuuc cu                                                22


<210>  1103
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1103
agaauggaga gagaauugaa aa                                                22


<210>  1104
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1104
agaauugaaa aaguggagca uu                                                22


<210>  1105
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1105
agacaagucu gaaugcucca cu                                                22


<210>  1106
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1106
agacacauag caauucagga aa                                                22


<210>  1107
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1107
agaccagucc uugcugaaag ac                                                22


<210>  1108
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1108
agacuugucu uucagcaagg ac                                                22


<210>  1109
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1109
agagaaugga aagucaaauu uc                                                22


<210>  1110
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1110
agagaauuga aaaaguggag ca                                                22


<210>  1111
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1111
agagagaauu gaaaaagugg ag                                                22


<210>  1112
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1112
agagauagaa agaccagucc uu                                                22


<210>  1113
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1113
agauagaaag accaguccuu gc                                                22


<210>  1114
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1114
agaugaguau gccugccgug ug                                                22


<210>  1115
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1115
agcaauucag gaaauuugac uu                                                22


<210>  1116
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1116
agcagagaau ggaaagucaa au                                                22


<210>  1117
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1117
agcauucaga cuugucuuuc ag                                                22


<210>  1118
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1118
agcccaagau aguuaagugg gg                                                22


<210>  1119
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1119
aggaaauuug acuuuccauu cu                                                22


<210>  1120
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1120
aggacugguc uuucuaucuc uu                                                22


<210>  1121
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1121
aggcauacuc aucuuuuuca gu                                                22


<210>  1122
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1122
agguacucca aagauucagg uu                                                22


<210>  1123
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1123
agguuuacuc acgucaucca gc                                                22


<210>  1124
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1124
aguaaaccug aaucuuugga gu                                                22


<210>  1125
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1125
aguaagucaa cuucaauguc gg                                                22


<210>  1126
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1126
aguacaagag auagaaagac ca                                                22


<210>  1127
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1127
aguaugccug ccgugugaac ca                                                22


<210>  1128
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1128
agucaaauuu ccugaauugc ua                                                22


<210>  1129
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1129
agucacaugg uucacacggc ag                                                22


<210>  1130
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1130
aguccuugcu gaaagacaag uc                                                22


<210>  1131
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1131
agucugaaug cuccacuuuu uc                                                22


<210>  1132
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1132
aguggagcau ucagacuugu cu                                                22


<210>  1133
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1133
aguguaguac aagagauaga aa                                                22


<210>  1134
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1134
aguugacuua cugaagaaug ga                                                22


<210>  1135
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1135
auacucaucu uuuucagugg gg                                                22


<210>  1136
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1136
auagaaagac caguccuugc ug                                                22


<210>  1137
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1137
auagcaauuc aggaaauuug ac                                                22


<210>  1138
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1138
auccagcaga gaauggaaag uc                                                22


<210>  1139
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1139
auccgacauu gaaguugacu ua                                                22


<210>  1140
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1140
aucucuugua cuacacugaa uu                                                22


<210>  1141
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1141
aucuugggcu gugacaaagu ca                                                22


<210>  1142
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1142
aucuuuuuca guggggguga au                                                22


<210>  1143
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1143
augaaaccca gacacauagc aa                                                22


<210>  1144
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1144
augacgugag uaaaccugaa uc                                                22


<210>  1145
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1145
augaguaugc cugccgugug aa                                                22


<210>  1146
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1146
augccugccg ugugaaccau gu                                                22


<210>  1147
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1147
augcuccacu uuuucaauuc uc                                                22


<210>  1148
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1148
auggaaaguc aaauuuccug aa                                                22


<210>  1149
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1149
auggagagag aauugaaaaa gu                                                22


<210>  1150
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1150
auggaugaaa cccagacaca ua                                                22


<210>  1151
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1151
augguucaca cggcaggcau ac                                                22


<210>  1152
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1152
augucggaug gaugaaaccc ag                                                22


<210>  1153
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1153
augugacuuu gucacagccc aa                                                22


<210>  1154
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1154
augugucugg guuucaucca uc                                                22


<210>  1155
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1155
auucaccccc acugaaaaag au                                                22


<210>  1156
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1156
auucagacuu gucuuucagc aa                                                22


<210>  1157
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1157
auucaggaaa uuugacuuuc ca                                                22


<210>  1158
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1158
auucagguuu acucacguca uc                                                22


<210>  1159
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1159
auucagugua guacaagaga ua                                                22


<210>  1160
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1160
auucucucuc cauucuucag ua                                                22


<210>  1161
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1161
auucucugcu ggaugacgug ag                                                22


<210>  1162
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1162
auucuucagu aagucaacuu ca                                                22


<210>  1163
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1163
auugaaaaag uggagcauuc ag                                                22


<210>  1164
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1164
auugaaguug acuuacugaa ga                                                22


<210>  1165
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1165
auuuccugaa uugcuaugug uc                                                22


<210>  1166
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1166
caaagauuca gguuuacuca cg                                                22


<210>  1167
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1167
caaagucaca ugguucacac gg                                                22


<210>  1168
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1168
caaauuuccu gaauugcuau gu                                                22


<210>  1169
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1169
caacuucaau gucggaugga ug                                                22


<210>  1170
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1170
caagagauag aaagaccagu cc                                                22


<210>  1171
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1171
caaggacugg ucuuucuauc uc                                                22


<210>  1172
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1172
caagucugaa ugcuccacuu uu                                                22


<210>  1173
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1173
caaugucgga uggaugaaac cc                                                22


<210>  1174
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1174
caauucagga aauuugacuu uc                                                22


<210>  1175
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1175
cacacggcag gcauacucau cu                                                22


<210>  1176
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1176
cacauagcaa uucaggaaau uu                                                22


<210>  1177
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1177
cacaugguuc acacggcagg ca                                                22


<210>  1178
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1178
cacccccacu gaaaaagaug ag                                                22


<210>  1179
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1179
cacggcaggc auacucaucu uu                                                22


<210>  1180
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1180
cacgucaucc agcagagaau gg                                                22


<210>  1181
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1181
cacugaaaaa gaugaguaug cc                                                22


<210>  1182
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1182
cacugaauuc acccccacug aa                                                22


<210>  1183
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1183
cacuuaacua ucuugggcug ug                                                22


<210>  1184
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1184
cacuuuuuca auucucucuc ca                                                22


<210>  1185
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1185
cagacacaua gcaauucagg aa                                                22


<210>  1186
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1186
cagacuuguc uuucagcaag ga                                                22


<210>  1187
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1187
cagagaaugg aaagucaaau uu                                                22


<210>  1188
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1188
cagcaaggac uggucuuucu au                                                22


<210>  1189
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1189
cagcagagaa uggaaaguca aa                                                22


<210>  1190
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1190
cagcccaaga uaguuaagug gg                                                22


<210>  1191
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1191
caggcauacu caucuuuuuc ag                                                22


<210>  1192
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1192
cagguacucc aaagauucag gu                                                22


<210>  1193
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1193
caguaaguca acuucaaugu cg                                                22


<210>  1194
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1194
caguccuugc ugaaagacaa gu                                                22


<210>  1195
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1195
caguguagua caagagauag aa                                                22


<210>  1196
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1196
cauacucauc uuuuucagug gg                                                22


<210>  1197
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1197
cauagcaauu caggaaauuu ga                                                22


<210>  1198
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1198
cauccagcag agaauggaaa gu                                                22


<210>  1199
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1199
cauccauccg acauugaagu ug                                                22


<210>  1200
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1200
cauccgacau ugaaguugac uu                                                22


<210>  1201
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1201
caucuuuuuc agugggggug aa                                                22


<210>  1202
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1202
caugguucac acggcaggca ua                                                22


<210>  1203
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1203
caugugacuu ugucacagcc ca                                                22


<210>  1204
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1204
cauucagacu ugucuuucag ca                                                22


<210>  1205
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1205
cauucuucag uaagucaacu uc                                                22


<210>  1206
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1206
cauugaaguu gacuuacuga ag                                                22


<210>  1207
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1207
ccaaagauuc agguuuacuc ac                                                22


<210>  1208
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1208
ccacugaaaa agaugaguau gc                                                22


<210>  1209
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1209
ccacuuaacu aucuugggcu gu                                                22


<210>  1210
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1210
ccacuuuuuc aauucucucu cc                                                22


<210>  1211
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1211
ccagacacau agcaauucag ga                                                22


<210>  1212
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1212
ccaguccuug cugaaagaca ag                                                22


<210>  1213
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1213
ccauccgaca uugaaguuga cu                                                22


<210>  1214
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1214
ccaugugacu uugucacagc cc                                                22


<210>  1215
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1215
ccauucucug cuggaugacg ug                                                22


<210>  1216
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1216
ccauucuuca guaagucaac uu                                                22


<210>  1217
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1217
cccacugaaa aagaugagua ug                                                22


<210>  1218
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1218
cccacuuaac uaucuugggc ug                                                22


<210>  1219
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1219
ccccacugaa aaagaugagu au                                                22


<210>  1220
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1220
ccccacuuaa cuaucuuggg cu                                                22


<210>  1221
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1221
cccccacuga aaaagaugag ua                                                22


<210>  1222
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1222
ccgacauuga aguugacuua cu                                                22


<210>  1223
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1223
ccgugugaac caugugacuu ug                                                22


<210>  1224
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1224
ccucagguac uccaaagauu ca                                                22


<210>  1225
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1225
ccugaauugc uaugugucug gg                                                22


<210>  1226
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1226
ccugccgugu gaaccaugug ac                                                22


<210>  1227
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1227
ccuugcugaa agacaagucu ga                                                22


<210>  1228
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1228
cgacauugaa guugacuuac ug                                                22


<210>  1229
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1229
cggauggaug aaacccagac ac                                                22


<210>  1230
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1230
cgucauccag cagagaaugg aa                                                22


<210>  1231
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1231
cgugaguaaa ccugaaucuu ug                                                22


<210>  1232
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1232
cgugugaacc augugacuuu gu                                                22


<210>  1233
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1233
cuacacugaa uucaccccca cu                                                22


<210>  1234
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1234
cuaucuuggg cugugacaaa gu                                                22


<210>  1235
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1235
cuaugugucu ggguuucauc ca                                                22


<210>  1236
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1236
cucagguacu ccaaagauuc ag                                                22


<210>  1237
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1237
cucaucuuuu ucaguggggg ug                                                22


<210>  1238
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1238
cuccaaagau ucagguuuac uc                                                22


<210>  1239
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1239
cuccacuuuu ucaauucucu cu                                                22


<210>  1240
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1240
cuccauucuu caguaaguca ac                                                22


<210>  1241
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1241
cucuccauuc uucaguaagu ca                                                22


<210>  1242
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1242
cucucuccau ucuucaguaa gu                                                22


<210>  1243
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1243
cucuuguacu acacugaauu ca                                                22


<210>  1244
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1244
cugaaaaaga ugaguaugcc ug                                                22


<210>  1245
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1245
cugaaagaca agucugaaug cu                                                22


<210>  1246
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1246
cugaagaaug gagagagaau ug                                                22


<210>  1247
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1247
cugaaugcuc cacuuuuuca au                                                22


<210>  1248
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1248
cugaauucac ccccacugaa aa                                                22


<210>  1249
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1249
cugccgugug aaccauguga cu                                                22


<210>  1250
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1250
cugcuggaug acgugaguaa ac                                                22


<210>  1251
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1251
cuggaugacg ugaguaaacc ug                                                22


<210>  1252
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1252
cuggguuuca uccauccgac au                                                22


<210>  1253
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1253
cuggucuuuc uaucucuugu ac                                                22


<210>  1254
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1254
cugugacaaa gucacauggu uc                                                22


<210>  1255
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1255
cuuaacuauc uugggcugug ac                                                22


<210>  1256
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1256
cuuaccccac uuaacuaucu ug                                                22


<210>  1257
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1257
cuuacugaag aauggagaga ga                                                22


<210>  1258
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1258
cuucaauguc ggauggauga aa                                                22


<210>  1259
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1259
cuucaguaag ucaacuucaa ug                                                22


<210>  1260
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1260
cuugcugaaa gacaagucug aa                                                22


<210>  1261
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1261
cuugggcugu gacaaaguca ca                                                22


<210>  1262
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1262
cuuguacuac acugaauuca cc                                                22


<210>  1263
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1263
cuugucuuuc agcaaggacu gg                                                22


<210>  1264
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1264
cuuucagcaa ggacuggucu uu                                                22


<210>  1265
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1265
cuuuccauuc ucugcuggau ga                                                22


<210>  1266
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1266
cuuucuaucu cuuguacuac ac                                                22


<210>  1267
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1267
cuuugucaca gcccaagaua gu                                                22


<210>  1268
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1268
cuuuuucaau ucucucucca uu                                                22


<210>  1269
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1269
cuuuuucagu gggggugaau uc                                                22


<210>  1270
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1270
gaaaaagaug aguaugccug cc                                                22


<210>  1271
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1271
gaaaaagugg agcauucaga cu                                                22


<210>  1272
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1272
gaaacccaga cacauagcaa uu                                                22


<210>  1273
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1273
gaaagacaag ucugaaugcu cc                                                22


<210>  1274
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1274
gaaagaccag uccuugcuga aa                                                22


<210>  1275
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1275
gaaagucaaa uuuccugaau ug                                                22


<210>  1276
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1276
gaaauuugac uuuccauucu cu                                                22


<210>  1277
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1277
gaaccaugug acuuugucac ag                                                22


<210>  1278
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1278
gaagaaugga gagagaauug aa                                                22


<210>  1279
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1279
gaaguugacu uacugaagaa ug                                                22


<210>  1280
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1280
gaaugcucca cuuuuucaau uc                                                22


<210>  1281
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1281
gaauggaaag ucaaauuucc ug                                                22


<210>  1282
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1282
gaauggagag agaauugaaa aa                                                22


<210>  1283
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1283
gaauucaccc ccacugaaaa ag                                                22


<210>  1284
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1284
gaauucagug uaguacaaga ga                                                22


<210>  1285
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1285
gaauugaaaa aguggagcau uc                                                22


<210>  1286
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1286
gaauugcuau gugucugggu uu                                                22


<210>  1287
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1287
gacaaaguca caugguucac ac                                                22


<210>  1288
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1288
gacacauagc aauucaggaa au                                                22


<210>  1289
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1289
gacauugaag uugacuuacu ga                                                22


<210>  1290
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1290
gacgugagua aaccugaauc uu                                                22


<210>  1291
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1291
gacuggucuu ucuaucucuu gu                                                22


<210>  1292
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1292
gacuuacccc acuuaacuau cu                                                22


<210>  1293
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1293
gacuuacuga agaauggaga ga                                                22


<210>  1294
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1294
gacuugucuu ucagcaagga cu                                                22


<210>  1295
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1295
gacuuuccau ucucugcugg au                                                22


<210>  1296
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1296
gacuuuguca cagcccaaga ua                                                22


<210>  1297
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1297
gagaauggaa agucaaauuu cc                                                22


<210>  1298
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1298
gagaauugaa aaaguggagc au                                                22


<210>  1299
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1299
gagagaauug aaaaagugga gc                                                22


<210>  1300
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1300
gagagagaau ugaaaaagug ga                                                22


<210>  1301
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1301
gagauagaaa gaccaguccu ug                                                22


<210>  1302
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1302
gagcauucag acuugucuuu ca                                                22


<210>  1303
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1303
gaguaaaccu gaaucuuugg ag                                                22


<210>  1304
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1304
gaguaugccu gccgugugaa cc                                                22


<210>  1305
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1305
gaugaaaccc agacacauag ca                                                22


<210>  1306
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1306
gaugacguga guaaaccuga au                                                22


<210>  1307
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1307
gaugaguaug ccugccgugu ga                                                22


<210>  1308
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1308
gauggaugaa acccagacac au                                                22


<210>  1309
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1309
gauucagguu uacucacguc au                                                22


<210>  1310
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1310
gcaaggacug gucuuucuau cu                                                22


<210>  1311
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1311
gcaauucagg aaauuugacu uu                                                22


<210>  1312
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1312
gcagagaaug gaaagucaaa uu                                                22


<210>  1313
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1313
gcaggcauac ucaucuuuuu ca                                                22


<210>  1314
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1314
gcauacucau cuuuuucagu gg                                                22


<210>  1315
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1315
gcauucagac uugucuuuca gc                                                22


<210>  1316
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1316
gccugccgug ugaaccaugu ga                                                22


<210>  1317
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1317
gcuauguguc uggguuucau cc                                                22


<210>  1318
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1318
gcuccacuuu uucaauucuc uc                                                22


<210>  1319
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1319
gcuggaugac gugaguaaac cu                                                22


<210>  1320
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1320
gcugugacaa agucacaugg uu                                                22


<210>  1321
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1321
ggaaagucaa auuuccugaa uu                                                22


<210>  1322
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1322
ggaaauuuga cuuuccauuc uc                                                22


<210>  1323
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1323
ggacuggucu uucuaucucu ug                                                22


<210>  1324
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1324
ggagagagaa uugaaaaagu gg                                                22


<210>  1325
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1325
ggagcauuca gacuugucuu uc                                                22


<210>  1326
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1326
ggaugaaacc cagacacaua gc                                                22


<210>  1327
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1327
ggaugacgug aguaaaccug aa                                                22


<210>  1328
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1328
ggauggauga aacccagaca ca                                                22


<210>  1329
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1329
ggcaggcaua cucaucuuuu uc                                                22


<210>  1330
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1330
ggcauacuca ucuuuuucag ug                                                22


<210>  1331
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1331
ggcugugaca aagucacaug gu                                                22


<210>  1332
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1332
gggcugugac aaagucacau gg                                                22


<210>  1333
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1333
gggggugaau ucaguguagu ac                                                22


<210>  1334
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1334
ggggugaauu caguguagua ca                                                22


<210>  1335
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1335
gggugaauuc aguguaguac aa                                                22


<210>  1336
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1336
ggguuucauc cauccgacau ug                                                22


<210>  1337
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1337
gguacuccaa agauucaggu uu                                                22


<210>  1338
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1338
ggucuuucua ucucuuguac ua                                                22


<210>  1339
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1339
gguuuacuca cgucauccag ca                                                22


<210>  1340
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1340
gguuucaucc auccgacauu ga                                                22


<210>  1341
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1341
guaaaccuga aucuuuggag ua                                                22


<210>  1342
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1342
guaagucaac uucaaugucg ga                                                22


<210>  1343
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1343
guacaagaga uagaaagacc ag                                                22


<210>  1344
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1344
guacuacacu gaauucaccc cc                                                22


<210>  1345
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1345
guacuccaaa gauucagguu ua                                                22


<210>  1346
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1346
guaguacaag agauagaaag ac                                                22


<210>  1347
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1347
guaugccugc cgugugaacc au                                                22


<210>  1348
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1348
gucaaauuuc cugaauugcu au                                                22


<210>  1349
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1349
gucaacuuca augucggaug ga                                                22


<210>  1350
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1350
gucacagccc aagauaguua ag                                                22


<210>  1351
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1351
gucacauggu ucacacggca gg                                                22


<210>  1352
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1352
gucauccagc agagaaugga aa                                                22


<210>  1353
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1353
guccuugcug aaagacaagu cu                                                22


<210>  1354
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1354
gucggaugga ugaaacccag ac                                                22


<210>  1355
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1355
gucugaaugc uccacuuuuu ca                                                22


<210>  1356
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1356
gucuggguuu cauccauccg ac                                                22


<210>  1357
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1357
gucuuucagc aaggacuggu cu                                                22


<210>  1358
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1358
gucuuucuau cucuuguacu ac                                                22


<210>  1359
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1359
gugaaccaug ugacuuuguc ac                                                22


<210>  1360
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1360
gugaauucag uguaguacaa ga                                                22


<210>  1361
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1361
gugacaaagu cacaugguuc ac                                                22


<210>  1362
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1362
gugaguaaac cugaaucuuu gg                                                22


<210>  1363
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1363
guggagcauu cagacuuguc uu                                                22


<210>  1364
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1364
guggggguga auucagugua gu                                                22


<210>  1365
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1365
guguaguaca agagauagaa ag                                                22


<210>  1366
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1366
guucacacgg caggcauacu ca                                                22


<210>  1367
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1367
guugacuuac ugaagaaugg ag                                                22


<210>  1368
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1368
guuuacucac gucauccagc ag                                                22


<210>  1369
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1369
guuucaucca uccgacauug aa                                                22


<210>  1370
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1370
uaaaccugaa ucuuuggagu ac                                                22


<210>  1371
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1371
uaacuaucuu gggcugugac aa                                                22


<210>  1372
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1372
uaagucaacu ucaaugucgg au                                                22


<210>  1373
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1373
uacaagagau agaaagacca gu                                                22


<210>  1374
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1374
uacacugaau ucacccccac ug                                                22


<210>  1375
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1375
uaccccacuu aacuaucuug gg                                                22


<210>  1376
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1376
uacuacacug aauucacccc ca                                                22


<210>  1377
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1377
uacucacguc auccagcaga ga                                                22


<210>  1378
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1378
uacucaucuu uuucaguggg gg                                                22


<210>  1379
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1379
uacuccaaag auucagguuu ac                                                22


<210>  1380
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1380
uacugaagaa uggagagaga au                                                22


<210>  1381
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1381
uagaaagacc aguccuugcu ga                                                22


<210>  1382
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1382
uagcaauuca ggaaauuuga cu                                                22


<210>  1383
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1383
uaguacaaga gauagaaaga cc                                                22


<210>  1384
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1384
uaucuugggc ugugacaaag uc                                                22


<210>  1385
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1385
uaugccugcc gugugaacca ug                                                22


<210>  1386
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1386
uaugugucug gguuucaucc au                                                22


<210>  1387
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1387
ucaaauuucc ugaauugcua ug                                                22


<210>  1388
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1388
ucaacuucaa ugucggaugg au                                                22


<210>  1389
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1389
ucaaugucgg auggaugaaa cc                                                22


<210>  1390
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1390
ucacaugguu cacacggcag gc                                                22


<210>  1391
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1391
ucacccccac ugaaaaagau ga                                                22


<210>  1392
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1392
ucacgucauc cagcagagaa ug                                                22


<210>  1393
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1393
ucagacuugu cuuucagcaa gg                                                22


<210>  1394
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1394
ucagcaagga cuggucuuuc ua                                                22


<210>  1395
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1395
ucaggaaauu ugacuuucca uu                                                22


<210>  1396
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1396
ucagguacuc caaagauuca gg                                                22


<210>  1397
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1397
ucagguuuac ucacgucauc ca                                                22


<210>  1398
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1398
ucaguaaguc aacuucaaug uc                                                22


<210>  1399
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1399
ucaguguagu acaagagaua ga                                                22


<210>  1400
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1400
ucauccagca gagaauggaa ag                                                22


<210>  1401
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1401
ucauccaucc gacauugaag uu                                                22


<210>  1402
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1402
ucaucuuuuu cagugggggu ga                                                22


<210>  1403
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1403
uccaaagauu cagguuuacu ca                                                22


<210>  1404
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1404
uccacuuuuu caauucucuc uc                                                22


<210>  1405
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1405
uccagcagag aauggaaagu ca                                                22


<210>  1406
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1406
uccauccgac auugaaguug ac                                                22


<210>  1407
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1407
uccauucucu gcuggaugac gu                                                22


<210>  1408
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1408
uccauucuuc aguaagucaa cu                                                22


<210>  1409
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1409
uccgacauug aaguugacuu ac                                                22


<210>  1410
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1410
uccucaggua cuccaaagau uc                                                22


<210>  1411
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1411
uccugaauug cuaugugucu gg                                                22


<210>  1412
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1412
ucggauggau gaaacccaga ca                                                22


<210>  1413
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1413
ucuaucucuu guacuacacu ga                                                22


<210>  1414
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1414
ucuccauucu ucaguaaguc aa                                                22


<210>  1415
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1415
ucucuccauu cuucaguaag uc                                                22


<210>  1416
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1416
ucucucucca uucuucagua ag                                                22


<210>  1417
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1417
ucucugcugg augacgugag ua                                                22


<210>  1418
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1418
ucucuuguac uacacugaau uc                                                22


<210>  1419
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1419
ucugaaugcu ccacuuuuuc aa                                                22


<210>  1420
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1420
ucugcuggau gacgugagua aa                                                22


<210>  1421
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1421
ucuggguuuc auccauccga ca                                                22


<210>  1422
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1422
ucuucaguaa gucaacuuca au                                                22


<210>  1423
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1423
ucuugggcug ugacaaaguc ac                                                22


<210>  1424
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1424
ucuuguacua cacugaauuc ac                                                22


<210>  1425
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1425
ucuuucagca aggacugguc uu                                                22


<210>  1426
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1426
ucuuucuauc ucuuguacua ca                                                22


<210>  1427
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1427
ucuuuuucag ugggggugaa uu                                                22


<210>  1428
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1428
ugaaaaagau gaguaugccu gc                                                22


<210>  1429
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1429
ugaaaaagug gagcauucag ac                                                22


<210>  1430
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1430
ugaaacccag acacauagca au                                                22


<210>  1431
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1431
ugaaagacaa gucugaaugc uc                                                22


<210>  1432
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1432
ugaaccaugu gacuuuguca ca                                                22


<210>  1433
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1433
ugaagaaugg agagagaauu ga                                                22


<210>  1434
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1434
ugaaguugac uuacugaaga au                                                22


<210>  1435
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1435
ugaaugcucc acuuuuucaa uu                                                22


<210>  1436
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1436
ugaauucacc cccacugaaa aa                                                22


<210>  1437
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1437
ugaauucagu guaguacaag ag                                                22


<210>  1438
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1438
ugaauugcua ugugucuggg uu                                                22


<210>  1439
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1439
ugacaaaguc acaugguuca ca                                                22


<210>  1440
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1440
ugacgugagu aaaccugaau cu                                                22


<210>  1441
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1441
ugacuuacug aagaauggag ag                                                22


<210>  1442
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1442
ugacuuucca uucucugcug ga                                                22


<210>  1443
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1443
ugacuuuguc acagcccaag au                                                22


<210>  1444
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1444
ugaguaaacc ugaaucuuug ga                                                22


<210>  1445
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1445
ugaguaugcc ugccguguga ac                                                22


<210>  1446
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1446
ugccugccgu gugaaccaug ug                                                22


<210>  1447
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1447
ugcuaugugu cuggguuuca uc                                                22


<210>  1448
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1448
ugcuccacuu uuucaauucu cu                                                22


<210>  1449
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1449
ugcugaaaga caagucugaa ug                                                22


<210>  1450
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1450
uggaaaguca aauuuccuga au                                                22


<210>  1451
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1451
uggagagaga auugaaaaag ug                                                22


<210>  1452
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1452
uggagcauuc agacuugucu uu                                                22


<210>  1453
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1453
uggaugaaac ccagacacau ag                                                22


<210>  1454
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1454
uggaugacgu gaguaaaccu ga                                                22


<210>  1455
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1455
ugggcuguga caaagucaca ug                                                22


<210>  1456
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1456
ugggggugaa uucaguguag ua                                                22


<210>  1457
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1457
uggguuucau ccauccgaca uu                                                22


<210>  1458
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1458
uggucuuucu aucucuugua cu                                                22


<210>  1459
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1459
ugguucacac ggcaggcaua cu                                                22


<210>  1460
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1460
uguacuacac ugaauucacc cc                                                22


<210>  1461
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1461
uguaguacaa gagauagaaa ga                                                22


<210>  1462
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1462
ugucacagcc caagauaguu aa                                                22


<210>  1463
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1463
ugucggaugg augaaaccca ga                                                22


<210>  1464
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1464
ugucuggguu ucauccaucc ga                                                22


<210>  1465
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1465
ugucuuucag caaggacugg uc                                                22


<210>  1466
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1466
ugugaaccau gugacuuugu ca                                                22


<210>  1467
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1467
ugugacaaag ucacaugguu ca                                                22


<210>  1468
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1468
ugugacuuug ucacagccca ag                                                22


<210>  1469
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1469
ugugucuggg uuucauccau cc                                                22


<210>  1470
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1470
uuaacuaucu ugggcuguga ca                                                22


<210>  1471
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1471
uuaccccacu uaacuaucuu gg                                                22


<210>  1472
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1472
uuacucacgu cauccagcag ag                                                22


<210>  1473
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1473
uuacugaaga auggagagag aa                                                22


<210>  1474
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1474
uucaaugucg gauggaugaa ac                                                22


<210>  1475
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1475
uucaauucuc ucuccauucu uc                                                22


<210>  1476
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1476
uucacacggc aggcauacuc au                                                22


<210>  1477
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1477
uucaccccca cugaaaaaga ug                                                22


<210>  1478
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1478
uucagacuug ucuuucagca ag                                                22


<210>  1479
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1479
uucagcaagg acuggucuuu cu                                                22


<210>  1480
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1480
uucaggaaau uugacuuucc au                                                22


<210>  1481
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1481
uucagguuua cucacgucau cc                                                22


<210>  1482
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1482
uucaguaagu caacuucaau gu                                                22


<210>  1483
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1483
uucagugggg gugaauucag ug                                                22


<210>  1484
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1484
uucaguguag uacaagagau ag                                                22


<210>  1485
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1485
uucauccauc cgacauugaa gu                                                22


<210>  1486
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1486
uuccauucuc ugcuggauga cg                                                22


<210>  1487
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1487
uuccucaggu acuccaaaga uu                                                22


<210>  1488
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1488
uuccugaauu gcuauguguc ug                                                22


<210>  1489
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1489
uucuaucucu uguacuacac ug                                                22


<210>  1490
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1490
uucucucucc auucuucagu aa                                                22


<210>  1491
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1491
uucucugcug gaugacguga gu                                                22


<210>  1492
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1492
uucuucagua agucaacuuc aa                                                22


<210>  1493
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1493
uugaaaaagu ggagcauuca ga                                                22


<210>  1494
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1494
uugaaguuga cuuacugaag aa                                                22


<210>  1495
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1495
uugacuuacu gaagaaugga ga                                                22


<210>  1496
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1496
uugacuuucc auucucugcu gg                                                22


<210>  1497
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1497
uugcuaugug ucuggguuuc au                                                22


<210>  1498
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1498
uugcugaaag acaagucuga au                                                22


<210>  1499
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1499
uugggcugug acaaagucac au                                                22


<210>  1500
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1500
uuguacuaca cugaauucac cc                                                22


<210>  1501
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1501
uugucacagc ccaagauagu ua                                                22


<210>  1502
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1502
uugucuuuca gcaaggacug gu                                                22


<210>  1503
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1503
uuuacucacg ucauccagca ga                                                22


<210>  1504
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1504
uuucaauucu cucuccauuc uu                                                22


<210>  1505
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1505
uuucagcaag gacuggucuu uc                                                22


<210>  1506
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1506
uuucaguggg ggugaauuca gu                                                22


<210>  1507
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1507
uuucauccau ccgacauuga ag                                                22


<210>  1508
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1508
uuuccauucu cugcuggaug ac                                                22


<210>  1509
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1509
uuuccugaau ugcuaugugu cu                                                22


<210>  1510
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1510
uuucuaucuc uuguacuaca cu                                                22


<210>  1511
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1511
uuugacuuuc cauucucugc ug                                                22


<210>  1512
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1512
uuugucacag cccaagauag uu                                                22


<210>  1513
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1513
uuuucaauuc ucucuccauu cu                                                22


<210>  1514
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1514
uuuucagugg gggugaauuc ag                                                22


<210>  1515
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1515
uuuuucaauu cucucuccau uc                                                22


<210>  1516
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1516
uuuuucagug ggggugaauu ca                                                22


<210>  1517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1517
augcugcuua caugucucga                                                   20


<210>  1518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1518
cugcuuacau gucucgaucu                                                   20


<210>  1519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1519
gcugcuuaca ugucucgauc                                                   20


<210>  1520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1520
ugcugcuuac augucucgau                                                   20


<210>  1521
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1521
gcugcuuaca ugucucgauc u                                                 21


<210>  1522
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1522
ugcugcuuac augucucgau c                                                 21


<210>  1523
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1523
uucauagauc gagacaugua a                                                 21


<210>  1524
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1524
uuucauagau cgagacaugu a                                                 21


<210>  1525
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1525
augcugcuua caugucucga uc                                                22


<210>  1526
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1526
ugcugcuuac augucucgau cu                                                22


<210>  1527
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1527
uucauagauc gagacaugua ag                                                22


<210>  1528
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1528
uuucauagau cgagacaugu aa                                                22


<210>  1529
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1529
gcauacucau cuuuuucagu g                                                 21


<210>  1530
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1530
gcgcgagcac agcuaaggcc a                                                 21


<210>  1531
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1531
gcucgcgcua cucucucuuu c                                                 21


<210>  1532
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1532
ucacagccca agauaguuaa g                                                 21


<210>  1533
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1533
gacaaaguca caugguucac a                                                 21


<210>  1534
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1534
acgugaguaa accugaaucu u                                                 21


<210>  1535
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1535
aagaauguaa gacuuacccc ac                                                22


<210>  1536
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1536
ucagcagcuu acaaaagaau gu                                                22


<210>  1537
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1537
cgucgcgcug gcgggcauuc cu                                                22


<210>  1538
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B2M-targeting guide sequence portion

<400>  1538
gcuggcgggc auuccugaag cu                                                22


<210>  1539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Example RNA guide sequence portion

<400>  1539
aaaaaaaugu acuugguucc                                                   20


<210>  1540
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  17 nucleotide guide sequence 1

<400>  1540
aaaauguacu ugguucc                                                      17


<210>  1541
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  17 nucleotide guide sequence 2

<400>  1541
aaaaauguac uugguuc                                                      17


<210>  1542
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  17 nucleotide guide sequence 3

<400>  1542
aaaaaaugua cuugguu                                                      17


<210>  1543
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  17 nucleotide guide sequence 4

<400>  1543
aaaaaaaugu acuuggu                                                      17


<210>  1544
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  TRAC-targeting gRNA32 guide sequence portion

<400>  1544
gccacuuuca ggaggaggau u                                                 21


<210>  1545
<211>  1348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OMNI-103 amino acid sequence

<400>  1545

Met Ser Ile Lys Ser Asp Tyr Phe Leu Gly Leu Asp Ile Gly Thr Asp 
1               5                   10                  15      


Ser Ile Gly Trp Ala Val Thr Asp Pro Glu Tyr His Ile Leu Arg Arg 
            20                  25                  30          


Lys Gly Lys Ala Leu Trp Gly Ile Arg Leu Phe Asp Ala Ala Asn Thr 
        35                  40                  45              


Ala Ala Glu Arg Arg Thr Phe Arg Thr Ser Arg Arg Arg Ile Gln Arg 
    50                  55                  60                  


Arg Arg Gln Arg Ile Arg Leu Leu Gln Glu Leu Phe Ala Glu Glu Met 
65                  70                  75                  80  


Val Lys Leu Asp Pro Gly Phe Phe Gln Arg Leu Ser Asp Ser Ala Phe 
                85                  90                  95      


Trp Gln Glu Asp Lys Gln Glu Gln Gln Ile Tyr Ser Leu Phe Thr Cys 
            100                 105                 110         


Glu Asn Tyr Thr Asp Val Asp Tyr Tyr Arg Glu Tyr Pro Thr Ile Tyr 
        115                 120                 125             


His Leu Arg Ser Ala Leu Ile Gln Glu Lys Lys Glu Phe Asp Leu Arg 
    130                 135                 140                 


Leu Leu Tyr Leu Ala Leu His His Leu Met Lys His Arg Gly His Phe 
145                 150                 155                 160 


Leu Phe Asn Gly Ser Ile Asn Asn Val Thr Ser Phe His Thr Thr Phe 
                165                 170                 175     


Gln Thr Phe Ala Asp Cys Leu Tyr Asp Glu Phe Asp Ile Glu Leu Glu 
            180                 185                 190         


Cys Asp Ser Glu Asp Arg Phe Ala Glu Ile Leu Lys Asp Lys His Ala 
        195                 200                 205             


Arg Lys Thr Gly Lys Cys Ser Glu Leu Glu Ile Ile Cys His Ile Glu 
    210                 215                 220                 


Lys Ser Asn Lys Gln Leu Lys Glu Leu Phe Lys Leu Ile Thr Gly Met 
225                 230                 235                 240 


Lys Ala Ser Leu Ser Val Val Phe Gly Asp Asp Glu Leu Ala Glu Ile 
                245                 250                 255     


Glu His Asn Lys Ile Ser Phe Ser Glu Ser Ser Tyr Asp Glu Val Arg 
            260                 265                 270         


Leu Ala Leu Glu Asp Glu Ile Gln Glu Arg Thr Gly Ile Leu Asp Ile 
        275                 280                 285             


Phe His Ala Val Tyr Ser Trp Ala Ile Leu Ala Asp Ile Leu Glu Gly 
    290                 295                 300                 


Gly Glu Tyr Glu Gly Asn Ser Tyr Leu Ser Val Ala Lys Val Ser Thr 
305                 310                 315                 320 


Tyr Lys Lys His Gly Asp Asp Leu Arg Leu Leu Arg Thr Leu Val Arg 
                325                 330                 335     


Glu Tyr Cys Pro Asp His Tyr Lys Ser Phe Phe Ser Val Ser Gly Lys 
            340                 345                 350         


Glu Asn Tyr Cys Ala Tyr Ala Gly Thr Leu Lys Lys Asn Gly Lys Lys 
        355                 360                 365             


Gln Pro Ile Lys Arg Cys Ser Gln Glu Asp Phe Tyr Lys Ala Leu Lys 
    370                 375                 380                 


Lys Leu Leu Asn Gln Met Pro Thr Glu Gln Pro Glu Val Lys Asp Ile 
385                 390                 395                 400 


Phe Ile Glu Ile Glu Asn Gly Thr Phe Leu Pro Leu Gln Val Ser Lys 
                405                 410                 415     


Asp Asn Gly Val Ile Pro Tyr Gln Val Asn Lys Met Glu Leu Glu Lys 
            420                 425                 430         


Ile Leu Gln Asn Ala Glu Glu Tyr Leu Pro Phe Leu Lys Asn Ile Asp 
        435                 440                 445             


Glu Glu Cys Gly Lys Thr Val Ser Lys Lys Ile Ile Asp Leu Phe Glu 
    450                 455                 460                 


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asn Thr Ala Lys Gly Glu 
465                 470                 475                 480 


Asn Cys Trp Met Val Arg Lys Glu Ala Gly Arg Ile Tyr Pro Trp Asn 
                485                 490                 495     


Phe Asp Glu Lys Val Asp Arg Asp Gln Ser Ala Glu Lys Phe Ile Arg 
            500                 505                 510         


Arg Met Thr Asn Gln Cys Thr Tyr Leu Ile His Glu Asp Val Val Pro 
        515                 520                 525             


Lys Asn Ser Leu Leu Tyr Ser Glu Phe Met Val Leu Asn Glu Leu Asn 
    530                 535                 540                 


Asn Val Lys Ile Arg Ser Glu Lys Leu Pro Val Glu Leu Lys Gln Ala 
545                 550                 555                 560 


Ile Val Leu Asp Leu Phe Lys Lys Gln Lys Gln Ile Thr Gly Lys Lys 
                565                 570                 575     


Leu Leu Asn Tyr Leu Asn Ala Asn Gly Tyr Asp Val Lys Lys Glu Asp 
            580                 585                 590         


Leu Ser Gly Phe Asp Gly Asn Phe Lys Ser Ser Leu Ser Ser Tyr Leu 
        595                 600                 605             


Thr Leu Lys Lys Val Phe Gly Glu Glu Leu Asp Lys Tyr Ser Val Gln 
    610                 615                 620                 


Gln Met Ala Glu Asp Ile Ile Leu Trp Ile Thr Leu Tyr Gly Asp Asp 
625                 630                 635                 640 


Gln Lys Met Leu Arg Arg Val Ile Arg Lys His Tyr Glu Gln Gln Leu 
                645                 650                 655     


Ser Glu Glu Gln Ile Leu Ser Leu Ser Lys Leu Lys Phe Gln Gly Trp 
            660                 665                 670         


Gly Arg Leu Ser Arg Arg Leu Leu Ser Glu Met Glu Gly Val Asp Cys 
        675                 680                 685             


Glu Thr Gly Glu Cys Met Thr Val Met Gln Gly Leu Arg Asn Thr Gln 
    690                 695                 700                 


Asn Asn Leu Met Gln Leu Leu Ser Gln Gln Phe Ser Phe Met Glu Leu 
705                 710                 715                 720 


Ile Glu Glu Glu Asn Gly Asn Tyr Tyr Val Asp Glu Ile Thr Tyr Asp 
                725                 730                 735     


Asn Leu Val Lys Asp Met Val Ile Ser Pro Ser Val Lys Arg Ala Val 
            740                 745                 750         


Trp Gln Thr Val Gln Ile Val Glu Glu Ile Lys Gly Val Met Gly Cys 
        755                 760                 765             


Gln Pro Lys Lys Ile Phe Val Glu Met Ala Arg Ser Asp Glu Glu Lys 
    770                 775                 780                 


Lys Arg Thr Val Ser Arg Lys Asp Arg Leu Leu Glu Ala Tyr Asp Ala 
785                 790                 795                 800 


Ile Lys Asp Glu Ala Arg Gln Trp Gln Glu Glu Leu Gln Lys Tyr Ser 
                805                 810                 815     


Asp Gly Asp Phe Lys Ala Ile Lys Leu Tyr Leu Tyr Tyr Thr Gln Met 
            820                 825                 830         


Gly Gln Cys Met Tyr Thr Gly Arg Lys Ile Asp Leu Ser Gln Leu Asn 
        835                 840                 845             


Asp Ala Thr Val Trp Asp Arg Asp His Ile Tyr Pro Gln Ser Lys Thr 
    850                 855                 860                 


Lys Asp Asp Ser Leu Asp Asn Leu Val Leu Val Asp Arg Ser Val Asn 
865                 870                 875                 880 


Ala Lys Lys Ser Asp Gly Met Leu Ser Pro Glu Ile Gln Gln Arg Met 
                885                 890                 895     


Arg Ala Thr Trp Lys Tyr Leu Lys Glu Lys Lys Leu Ile Ser Glu Lys 
            900                 905                 910         


Lys Tyr Glu Arg Leu Thr Arg Val Ser Pro Leu Thr Asp Glu Glu Leu 
        915                 920                 925             


Ala Gly Phe Ile Asn Arg Gln Leu Val Glu Thr Arg Gln Ser Ser Lys 
    930                 935                 940                 


Ala Val Ala Thr Leu Leu Lys Arg Val Tyr Asp Glu Ala Glu Ile Val 
945                 950                 955                 960 


Tyr Val Lys Ala Glu Ala Val Ser Asn Phe Arg Arg Asp Asn Leu Asp 
                965                 970                 975     


Tyr Ile Lys Val Arg Asp Leu Asn Asp Tyr His His Ala Lys Asp Ala 
            980                 985                 990         


Tyr Gln Asn Ile Val Val Gly Asn  Val Phe His Glu Lys  Phe Thr Ser 
        995                 1000                 1005             


Asn Pro  Leu Arg Trp Leu Lys  Asn Asn Pro Asn Thr  Lys Tyr Ser 
    1010                 1015                 1020             


Leu Asn  Gln Met Phe Asn Phe  Asp Leu Glu Lys Asn  Gly Val Val 
    1025                 1030                 1035             


Ile Trp  Lys Arg Gly Lys Ala  Gly Ser Ile Lys Cys  Val Glu Glu 
    1040                 1045                 1050             


Thr Leu  Lys Arg Asn Asp Ile  Leu Phe Thr Arg Tyr  Ala Phe Cys 
    1055                 1060                 1065             


Asn Lys  Gly Gly Phe Phe Asn  Gln Met Leu Thr Ala  Ala Pro Glu 
    1070                 1075                 1080             


Asp Lys  Thr Lys Ala Lys Gly  Leu Val Pro Ile Lys  Lys Gly Met 
    1085                 1090                 1095             


Glu Thr  Trp Lys Tyr Gly Gly  Tyr Thr Ser Val Thr  Pro Ser His 
    1100                 1105                 1110             


Phe Met  Leu Val Ala Ser Lys  Asp Lys Lys Gly Lys  Glu Ile Arg 
    1115                 1120                 1125             


Thr Ile  Glu Thr Val Pro Leu  Tyr Arg Trp Lys Glu  Phe Lys Glu 
    1130                 1135                 1140             


Asn Pro  Asp Ala Leu Leu Gln  Tyr Cys Arg Glu Phe  Tyr Gly Leu 
    1145                 1150                 1155             


Lys Glu  Pro Lys Val Leu Ile  Pro Cys Ile Lys Lys  Asn Ala Arg 
    1160                 1165                 1170             


Leu Val  Val Asn Gly Phe Pro  Met His Leu Lys Gly  Ser Thr Gly 
    1175                 1180                 1185             


Lys Gln  Leu Ile Leu Gln Gly  Ala Val Gln Leu Cys  Leu Asn Asn 
    1190                 1195                 1200             


Glu Asn  Ile Lys Tyr Leu Lys  Lys Val Thr Lys Tyr  Leu Glu Tyr 
    1205                 1210                 1215             


Asn Ala  Gln Arg Arg Asp Lys  Arg Thr Leu Leu Glu  Val Arg Glu 
    1220                 1225                 1230             


Val Thr  Gly Ile Asn Lys Glu  Glu Asn Ile Gln Leu  Tyr Asp Val 
    1235                 1240                 1245             


Phe Val  Asp Lys Leu Ser Asn  Thr Ile Tyr Gln Tyr  Arg Pro Ala 
    1250                 1255                 1260             


Asn Pro  Lys Asp Asn Leu Ile  Lys Gly Arg Glu Lys  Phe Ile Glu 
    1265                 1270                 1275             


Leu Gly  Leu Ala Glu Gln Cys  Val Val Leu Gly Glu  Val Leu His 
    1280                 1285                 1290             


Leu Phe  Gln Cys Lys Pro Leu  Thr Ser Asp Leu Thr  Leu Ile Gly 
    1295                 1300                 1305             


Gly Ser  Pro Asn Thr Gly Thr  Ile Lys Ile Thr Lys  Thr Ile Ser 
    1310                 1315                 1320             


Asn Cys  Asn Val Val Lys Leu  Leu Ser Gln Ser Ile  Ala Gly Val 
    1325                 1330                 1335             


Lys Val  Arg Glu Ile Asn Leu  Leu Ile Ile 
    1340                 1345             


<210>  1546
<211>  1097
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OMNI-124 amino acid sequence

<400>  1546

Met Gly Lys Ile Ile Gly Leu Asp Ile Gly Ile Ala Ser Val Gly Trp 
1               5                   10                  15      


Ala Val Leu Asp Lys Asp Ser Tyr Lys Ile Val Glu Ala Gly Ser Asn 
            20                  25                  30          


Ile Phe Pro Ala Ala Glu Ala Ser Lys Asn Gln Glu Arg Arg Glu Phe 
        35                  40                  45              


Arg Gly Leu Arg Arg Met Thr Arg Arg Arg Arg Thr Arg Leu Asp Asp 
    50                  55                  60                  


Phe Lys Lys Leu Trp Lys Asn Tyr Tyr Lys Asn Glu Tyr Ser Val Thr 
65                  70                  75                  80  


Pro Asn Asn Val Thr Glu Leu Lys Val Lys Gly Leu Ser Glu Gln Leu 
                85                  90                  95      


Ser Glu Leu Glu Leu Tyr Thr Val Leu Tyr Ser Tyr Leu Lys His Arg 
            100                 105                 110         


Gly Ile Ser Tyr Leu Glu Asp Ala Val Asp Glu Gly Lys Thr Gly Ser 
        115                 120                 125             


Asp Tyr Leu Lys Gly Leu Gln Thr Asn Gln Lys Glu Met Asn Thr Lys 
    130                 135                 140                 


Phe Pro Ser Gln Ile Gln Tyr Glu Arg Leu Glu Lys Tyr Gly Cys Phe 
145                 150                 155                 160 


Arg Gly Glu Asn Lys Val Ser Asp Asp Glu Val Leu Ser Asn Val Phe 
                165                 170                 175     


Thr Thr Ser Ala Tyr Lys Lys Glu Ile Glu Glu Leu Ile Ser Val Gln 
            180                 185                 190         


Asp Asn Leu Gly Asn Glu Leu Asp Lys Asp Phe Ile Lys Lys Tyr Phe 
        195                 200                 205             


Glu Ile Phe Ser Arg Lys Arg Lys Tyr Tyr Glu Gly Pro Gly Asn Glu 
    210                 215                 220                 


Leu Ser Arg Thr Asp Tyr Gly Ile Tyr Thr Thr Lys Ile Asp Glu Asn 
225                 230                 235                 240 


Gly Asn Tyr Ile Thr Asp Lys Asn Leu Phe Glu Lys Leu Ile Gly Lys 
                245                 250                 255     


Cys Ser Val Tyr Pro Glu Glu Met Arg Ala Ser Ala Ala Ser Tyr Thr 
            260                 265                 270         


Ala Gln Glu Phe Asn Ala Leu Asn Asp Leu Asn Asn Leu Ile Val Asn 
        275                 280                 285             


Gly Arg Lys Leu Thr Lys Glu Glu Lys Ile Ser Ile Ile Glu Cys Tyr 
    290                 295                 300                 


Lys Thr Glu Lys Thr Ile Asn Val Arg Lys Ile Ile Lys Asn Val Ile 
305                 310                 315                 320 


Gly Glu Asn Ile Asp Gln Leu Ser Gly Tyr Arg Met Asp Lys Asn Asp 
                325                 330                 335     


Lys Glu Leu Tyr His Thr Phe Glu Val Tyr Asn Lys Leu Arg Lys Ala 
            340                 345                 350         


Phe Glu Glu Ala Gly Ile Ser Phe Asp Phe Ser Arg Glu Asp Phe Asp 
        355                 360                 365             


Glu Ile Gly Arg Ile Leu Thr Leu Asn Ile Glu Arg Glu Gly Ile Glu 
    370                 375                 380                 


Asp Ala Ile Arg Ile Ser Asn Leu Val Leu Ser Ser Asp Ala Val Asp 
385                 390                 395                 400 


Val Leu Ile Ser Val Arg Lys Lys Asn Ala Ser Leu Phe Ser Lys Trp 
                405                 410                 415     


His Ser Phe Ser Leu Lys Ile Met Asn Glu Leu Ile Pro Glu Met Tyr 
            420                 425                 430         


Glu Gln Pro Lys Asn Gln Met Glu Leu Leu Ser Asp Met Lys Ser Ile 
        435                 440                 445             


Lys Ser Lys Met Asp Glu Phe Lys Gly Leu Glu Asp Ile Pro Val Glu 
    450                 455                 460                 


Thr Ile Ile Glu Asp Ile Tyr Asn Pro Val Val Lys Arg Ser Ile Arg 
465                 470                 475                 480 


Ile Thr Ile Lys Ile Ile Asn Ala Leu Lys Lys Lys Tyr Ser Asp Ile 
                485                 490                 495     


Glu Lys Ile Val Ile Glu Met Pro Arg Asp Lys Asn Ser Asp Glu Glu 
            500                 505                 510         


Lys Glu Arg Ile Lys Lys Phe Gln Lys Asp Gln Glu Asn Glu Leu Pro 
        515                 520                 525             


Asn Ile Ile Lys Arg Val Lys Asp Glu Tyr Gly Ile Thr Leu Thr Pro 
    530                 535                 540                 


Glu Leu Ile Ala Arg Lys Lys Gly Leu Ala Phe Lys Leu Lys Leu Trp 
545                 550                 555                 560 


Asn Glu Gln Asn Gly Arg Cys Pro Tyr Ser Gly Arg Met Ile Asp Ile 
                565                 570                 575     


Glu Ser Leu Ile Asn Asp Gly Asp Leu Phe Glu Val Asp His Ile Ile 
            580                 585                 590         


Pro Leu Ser Ile Ser Phe Asp Asp Ser Arg Ser Asn Lys Thr Leu Val 
        595                 600                 605             


Tyr Arg Val Glu Asn Gln Glu Lys Lys Asn Asn Thr Pro Phe Met Tyr 
    610                 615                 620                 


Leu Ser Arg Leu Asn Arg Gln Trp Asn Tyr Asp Lys Phe Ala Ala Phe 
625                 630                 635                 640 


Ile Lys Glu Leu Tyr Gly Ser Ser Gly Lys Asp Arg Lys Lys Phe Arg 
                645                 650                 655     


Lys Lys Met Asn Asn Phe Leu Phe Thr Glu Asp Ile Asn Lys Ile Asp 
            660                 665                 670         


Val Leu Lys Gly Phe Ile Asn Arg Asn Ile Asn Asp Thr Arg Tyr Ala 
        675                 680                 685             


Ser Arg Val Val Leu Asn Ser Leu Gln Gly Tyr Phe Arg Ala Asn Asp 
    690                 695                 700                 


Asn Asn Val Lys Val Ser Val Ile Asn Gly Ser Phe Thr His Gln Met 
705                 710                 715                 720 


Arg Val Asn Leu Ser Leu Gly Lys Asp Arg Asp Glu Ser Phe Ala His 
                725                 730                 735     


His Ala Val Asp Ala Met Leu Ile Ala Leu Ser Gln Met Gly Tyr Asp 
            740                 745                 750         


Ala Phe Arg Ala Arg Gln Lys Asp Ile Val Asp Phe Glu Thr Gly Glu 
        755                 760                 765             


Ile Ile Asn Gly Ser Ala Trp Glu Asn Gln Asp Glu Met Tyr Lys Thr 
    770                 775                 780                 


Val Leu Tyr Gln Glu Lys Trp Lys Asn Ile Lys Asp Asn Ile Ile Glu 
785                 790                 795                 800 


Ala Glu Pro Asn Ile Lys Tyr Trp His Lys Val Asp Lys Lys Cys Asn 
                805                 810                 815     


Arg Gly Leu Cys Asn Gln Thr Ile Tyr Ser Thr Arg Lys Cys Asp Asp 
            820                 825                 830         


Lys Ile Trp Lys Val Asp Lys Leu Asn Ile Arg Asp Lys Asp Asp Val 
        835                 840                 845             


Lys Lys Leu Ile Tyr Met Ile Gln Asn Gly Lys Glu Asp Lys Ile Leu 
    850                 855                 860                 


Met Ala Gln Asn Asp Pro Lys Thr Phe Ala Asn Leu Lys Tyr Ile Leu 
865                 870                 875                 880 


Asp Glu Tyr Ser Asp Cys Glu Asn Pro Phe Val Ser Tyr Glu Lys Glu 
                885                 890                 895     


Thr Gly Asp Leu Val Arg Lys Tyr Ser Lys Lys His Asn Gly Pro Lys 
            900                 905                 910         


Ile Thr Tyr Leu Lys Tyr Met Val Glu Glu Val Asn Ser Cys Ile Asp 
        915                 920                 925             


Ile Ser His Lys Tyr Gly His Glu Lys Gly Ser Lys Lys Val Phe Leu 
    930                 935                 940                 


Ala Gln Leu Val Pro Phe Arg Thr Asp Val Tyr Tyr Asn Asn Asn Ser 
945                 950                 955                 960 


Gly Lys Tyr Tyr Leu Ile Gly Ile Lys Gln Ser Asp Ile Lys Cys Lys 
                965                 970                 975     


Gly Asn Gln Tyr Ile Ile Asp Glu Glu Lys Tyr Thr Asp Asn Leu Ile 
            980                 985                 990         


Gln Asn Gly Leu Leu Lys Glu Gly  Gln Lys Ile Glu Asp  Leu Glu Lys 
        995                 1000                 1005             


Leu Gly  Tyr Leu Phe Lys Phe  Ser Ile Phe Lys Asn  Asp Thr Ile 
    1010                 1015                 1020             


Glu Phe  Glu Lys Lys Gly Glu  Leu Ile Lys Cys Arg  Phe Leu Ser 
    1025                 1030                 1035             


Gln Asn  Ser Ala Ser Lys Asn  Arg Ile Glu Val Lys  Pro Ile Gly 
    1040                 1045                 1050             


Lys Lys  Asp Tyr Glu Ser Arg  Asn Leu Pro Thr Leu  Ser Thr Thr 
    1055                 1060                 1065             


Thr Val  Ile Asn Lys Tyr Val  Lys Asp Ile Leu Gly  Asn Glu Lys 
    1070                 1075                 1080             


Gln Val  Ser Gly Glu Lys Phe  Glu Ile Ile Val Asp  Ser Lys 
    1085                 1090                 1095         


<210>  1547
<211>  1109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OMNI-127 amino acid sequence

<400>  1547

Met Gly Lys Leu Val Leu Gly Leu Asp Ile Gly Ile Thr Ser Val Gly 
1               5                   10                  15      


Tyr Gly Val Ile Asp Ile Asp Asn Asn Lys Phe Val Asp Tyr Gly Val 
            20                  25                  30          


Arg Leu Phe Lys Glu Gly Asp Ser Asn Asp Asn Glu Lys Arg Arg Ser 
        35                  40                  45              


Tyr Arg Ser Gly Arg Arg Leu Arg Arg Arg Lys Lys Asn Arg Leu Asp 
    50                  55                  60                  


Asp Met Lys Ser Leu Leu Leu Ser Ala Gly Ile Leu Thr Lys Asp Tyr 
65                  70                  75                  80  


Lys Pro Leu Asn Asn Ile Tyr Glu Ile Arg Val Lys Gly Leu Thr Glu 
                85                  90                  95      


Lys Leu Thr Asn Asn Glu Leu Ala Ala Ala Leu Leu His Ile Thr Lys 
            100                 105                 110         


Asn Arg Gly Thr Thr Val Glu Ala Leu Glu Thr Ala Asp Ala Asp Lys 
        115                 120                 125             


Glu Ala Ala Gly Thr Lys Asp Val Leu Ala Lys Asn Ala Lys Asp Leu 
    130                 135                 140                 


Glu Gln Phe Glu Tyr Val Cys Lys Val Gln Leu Tyr Arg Leu Glu Lys 
145                 150                 155                 160 


Tyr Gly Asn Ile Arg Gly Thr Glu Asn Asn Phe Asn Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Arg Ala Ile Leu Lys Cys Gln Asp Ile Asp Val Glu 
            180                 185                 190         


Leu Ser Glu Ser Ile Val Asn Ile Ile Ser Arg Arg Arg Glu Tyr Tyr 
        195                 200                 205             


Glu Gly Pro Gly Ser Glu Lys Ser Pro Thr Lys Tyr Gly Arg Trp Ile 
    210                 215                 220                 


Glu Lys Gly Ala Glu Pro Ile Asp Leu Ile Glu Lys Met Arg Gly Lys 
225                 230                 235                 240 


Cys Ser Ile Tyr His Asp Glu Leu Arg Ala Pro Lys Ser Ser Tyr Ser 
                245                 250                 255     


Ala Glu Leu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Ser Ile Asn 
            260                 265                 270         


Gly Glu Lys Leu Thr Gln Asn Glu Lys Glu Ile Val Ile Glu Glu Val 
        275                 280                 285             


Asn Asn Asn Gly Lys Ile Thr Ile Asp Lys Leu Lys Lys Leu Leu Asn 
    290                 295                 300                 


Ile Asn Asp Ser Lys Asp Val Val Glu Gly Phe Arg Ile Asn Lys Ser 
305                 310                 315                 320 


Asn Glu Leu Leu Leu Thr Asn Met Ala Met Tyr Asp Gln Phe Lys Lys 
                325                 330                 335     


Ile Phe Asp Lys His Lys Glu Asp Ala Tyr Gln Arg Asp Lys Tyr Ile 
            340                 345                 350         


Ile Asp Gln Ile Ala Glu Ile Asn Thr Ala Lys Lys Gly Ile Lys Glu 
        355                 360                 365             


Arg Cys Asp Ala Ile Glu Lys Gln Phe Pro Asn Phe Asp Tyr Asn Leu 
    370                 375                 380                 


Ile Arg Asp Leu Ala Glu Met Lys Lys Met Thr Gln Tyr His Ser Leu 
385                 390                 395                 400 


Ser Leu Lys Ala Ile Arg Glu Ile Asn Lys Glu Met Ile Lys Ser Pro 
                405                 410                 415     


Tyr Asn Gln Met Gln Ala Ile His Glu Leu Gly Leu Gln His Tyr Arg 
            420                 425                 430         


Lys Ser Tyr Lys Gly Met Lys Lys Ile Gln Val Asp Glu Glu Ala Ile 
        435                 440                 445             


Leu Ser Pro Val Val Lys Arg Ala Gln Arg Glu Thr Phe Lys Val Ile 
    450                 455                 460                 


Asn Arg Leu Arg Glu Ile Tyr Gly Glu Phe Glu Ser Ile Val Val Glu 
465                 470                 475                 480 


Thr Thr Arg Asp Lys Asn Ser Lys Glu Lys Lys Glu Arg Ile Asn Lys 
                485                 490                 495     


Thr Gln Lys Tyr Tyr Glu Asp Arg Asn Lys Lys Val Asp Glu Leu Leu 
            500                 505                 510         


Lys Glu Arg Gly Tyr Asn Pro Asp Thr Ile Asn Asn Lys Thr Lys Met 
        515                 520                 525             


Lys Val Lys Leu Tyr Leu Asp Gln Asn Gly Lys Ser Ala Tyr Thr Met 
    530                 535                 540                 


Thr Pro Leu Lys Leu Asn Leu Ile Ile Thr Asn Pro His Ala Tyr Glu 
545                 550                 555                 560 


Ile Asp His Ile Ile Pro Leu Ser Ile Ser Gln Asp Asp Ser Phe Asn 
                565                 570                 575     


Asn Lys Val Leu Ile Thr His Glu Glu Asn Gln Val Lys Gly Asn Lys 
            580                 585                 590         


Thr Pro Ile Tyr Thr Tyr Leu Asn Asn Gln Phe Lys Asn Cys Asp Ile 
        595                 600                 605             


Asn Lys Tyr Lys Glu Ser Val Lys Asn Asn His Asn Phe Ser Arg Lys 
    610                 615                 620                 


Lys Lys Phe Tyr Met Leu Tyr Glu Lys Asp Ile Thr Lys Tyr Ser Asn 
625                 630                 635                 640 


Met Lys Glu Phe Ile Ala Arg Asn Leu Val Asp Thr Ser Tyr Ala Ser 
                645                 650                 655     


Arg Val Val Leu Asn Thr Leu Thr Ser Tyr Phe Arg Asp Asn Asp Ile 
            660                 665                 670         


Ser Thr Asn Val His Thr Ile Arg Gly Ser Ala Thr Ser Leu Tyr Arg 
        675                 680                 685             


Lys Arg Ile Gly Leu Lys Lys Asp Arg Asp Lys Asp Phe Leu His His 
    690                 695                 700                 


Ala Ile Asp Ala Leu Ile Val Ala Ser Ile Lys Lys Gln Ser Ile Phe 
705                 710                 715                 720 


Arg Lys Tyr Leu Ile Lys Tyr Asn Leu Ser Glu Leu Tyr Asn Glu Lys 
                725                 730                 735     


Thr Gly Glu Leu Ile Lys Val Glu Glu Asp Ser Lys Val Ile Asp Pro 
            740                 745                 750         


Val Phe Ile Glu Phe Ile Ser Asn Leu Lys Thr Ile Tyr Glu Gln Ser 
        755                 760                 765             


Tyr Gln Tyr Tyr Asn Gly Tyr Ile Ser Arg Asn Lys Met Lys Phe Lys 
    770                 775                 780                 


Pro Ile Lys Ile Ser His Lys Val Asp Thr Lys Pro Asn Arg Lys Ile 
785                 790                 795                 800 


Ser Asp Glu Thr Ile Tyr Ser Thr Arg Asn Val Asn Gly Val Glu Arg 
                805                 810                 815     


Val Val Lys Lys Val Lys Asp Ile Tyr Asp Pro Lys Phe Asp Lys Leu 
            820                 825                 830         


Thr Asn Asp Ile Ile Asn Asn Gln Tyr His Asn Lys Trp Ile Met Ala 
        835                 840                 845             


Glu Lys Asp Glu Gln Thr Phe Glu Ile Ile Lys Ser Ile Val Met Ala 
    850                 855                 860                 


His Phe Asn Thr Tyr Lys Glu Asp Lys Asp Ile Tyr Lys Ser Lys Ser 
865                 870                 875                 880 


Lys Lys Gly Val Thr Thr Trp Ser Leu Lys Gly Ser Asn Asn Pro Leu 
                885                 890                 895     


Ser Gln Phe Lys Glu Glu His Gly Lys Ile Arg Lys Tyr Ser Lys Lys 
            900                 905                 910         


Gly Asn Gly Pro Glu Ile Thr Ser Met Lys Tyr Tyr Glu Asp Glu Leu 
        915                 920                 925             


Gly Asn His Val Asn Ile Thr Lys Lys Tyr Asn Val Asp Asn Lys Asn 
    930                 935                 940                 


Val Val Leu Leu Gln Ile Ser Pro Tyr Arg Thr Asp Phe Tyr Val Ser 
945                 950                 955                 960 


Pro Lys Gly Lys Tyr Lys Phe Val Thr Ile Arg Tyr Cys Asn Val Phe 
                965                 970                 975     


Tyr Lys Glu Ser Asn Lys Lys Tyr Leu Ile Asp Lys Lys Trp Tyr Glu 
            980                 985                 990         


Glu Glu Lys Lys Lys Lys Lys Ile  Asp Asp Ser Tyr Gln  Phe Val Cys 
        995                 1000                 1005             


Ser Leu  His His Asp Glu Ile  Leu Gly Val Lys Leu  Glu Asp Gly 
    1010                 1015                 1020             


Lys Pro  Tyr Ile Tyr Asp Glu  Ser Asn Glu Asn Asp  Glu Gly Leu 
    1025                 1030                 1035             


Lys Arg  Tyr His Lys Gly Gln  Tyr Glu Ile Leu Lys  Phe Thr Ala 
    1040                 1045                 1050             


Thr Asn  Asp Asp Lys Lys Asn  Ile Ile Glu Ile Lys  Pro Thr Tyr 
    1055                 1060                 1065             


Thr Tyr  Cys Gln Lys Gln Leu  Lys Arg Ser Cys Gly  Thr Phe Ile 
    1070                 1075                 1080             


Lys Leu  Thr Lys Phe Ala Thr  Asp Val Leu Gly Asn  Met Tyr Glu 
    1085                 1090                 1095             


Val Lys  Asp Asn Val Leu Lys  Leu Glu Phe Asp 
    1100                 1105                 


<210>  1548
<211>  1215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OMNI-218 amino acid sequence

<400>  1548

Met Ser Lys Lys Arg Ile Leu Gly Leu Asp Thr Gly Thr Asn Ser Leu 
1               5                   10                  15      


Gly Trp Ala Val Val Asp Gln Glu Glu Asn Gly Gln Tyr Thr Leu Ile 
            20                  25                  30          


Asp Lys Gly Val Val Ile Phe Gln Glu Gly Val Lys Ile Glu Lys Gly 
        35                  40                  45              


Val Glu Ser Ser Lys Ala Ala Glu Arg Thr Glu His Arg Ala Leu Arg 
    50                  55                  60                  


Arg His Tyr Phe Arg Arg Arg Leu Arg Lys Ile Glu Val Leu Arg Val 
65                  70                  75                  80  


Leu Val Lys Tyr Asn Leu Cys Pro Thr Ile Thr Glu Glu Asp Leu Asn 
                85                  90                  95      


Leu Trp Lys Leu His Lys Thr Tyr Pro Arg Lys Asp Glu Phe Met Val 
            100                 105                 110         


Trp Gln His Thr Asn Asp Asn Glu Asp Ile Asn Pro Tyr His Cys Arg 
        115                 120                 125             


Tyr Thr Cys Leu Asn Glu Asn Leu Asp Leu Asp Arg Gln Gln Asp Arg 
    130                 135                 140                 


Tyr Ile Leu Gly Arg Ala Leu Tyr His Met Ala Gln Arg Arg Gly Phe 
145                 150                 155                 160 


Leu Ser Asn Arg Leu Asp Ala Thr Glu Glu Asp Glu Asn Gly Ala Val 
                165                 170                 175     


Lys Ser Ser Ile Ala Asn Leu Asn Lys Glu Ile Glu Glu Asn Gly Cys 
            180                 185                 190         


Lys Tyr Leu Gly Glu Tyr Phe Tyr Lys Leu Tyr Lys Glu Lys Gly Asn 
        195                 200                 205             


Thr Val Arg Ile Arg Thr Arg Tyr Thr Asp Arg Glu Gln His Tyr Lys 
    210                 215                 220                 


Lys Glu Phe Phe Ala Ile Cys Glu Lys Gln Asn Leu Pro Lys Glu Met 
225                 230                 235                 240 


Val Glu Ala Leu Thr Arg Ala Leu Tyr Phe Gln Arg Pro Leu Lys Ser 
                245                 250                 255     


Gln Arg Gln Asn Val Gly Lys Cys Thr Phe Glu Lys Gly Lys Pro Arg 
            260                 265                 270         


Cys Ser Asp Ser His Pro Thr Tyr Glu Ile Tyr Arg Met Leu Ser Phe 
        275                 280                 285             


Leu Asn Asn Val Lys Ile Gln Gly Pro Trp Asp Glu Asp Leu Arg Pro 
    290                 295                 300                 


Leu Asn Glu Glu Glu Leu Lys Gln Ile Asp Lys Leu Phe Tyr Arg Lys 
305                 310                 315                 320 


Ser Lys Pro Asn Phe Asp Phe Glu Glu Ile Ala Lys Lys Ile Ala Gly 
                325                 330                 335     


Lys Gly Lys Tyr Gln Trp Lys Gly Asp Thr Lys Thr Asp Leu Pro Tyr 
            340                 345                 350         


Lys Phe Asn Tyr Arg Met Ser Gln Gly Val Pro Gly Cys Pro Thr Ile 
        355                 360                 365             


Ala Gln Leu Lys Glu Ile Phe Gly Glu Asn Trp Lys Glu Asn Ile Ala 
    370                 375                 380                 


Glu Thr Tyr Thr Leu Asn Thr Lys Lys Asp Gly Thr His Lys Ser Ala 
385                 390                 395                 400 


Asp Glu Met Val Asp Asp Ile Trp Asn Val Leu Phe Phe Phe Asp Ser 
                405                 410                 415     


Lys Asp Lys Val Lys Glu Tyr Gly Ile Lys His Leu Gln Leu Asp Glu 
            420                 425                 430         


Asp Gln Ala Asp Lys Phe Ser Lys Ile Arg Leu Ser Arg Asn Tyr Ala 
        435                 440                 445             


Ser Leu Ser Leu Lys Ala Ile Arg Tyr Ile Leu Pro Phe Leu His Lys 
    450                 455                 460                 


Gly Met Ile Tyr Ser Asp Ala Val Phe Phe Ala Lys Ile Pro Val Ile 
465                 470                 475                 480 


Ile Gly Gln Ser Leu Trp Gln Lys Arg Gln His Glu Ile Met Glu Asp 
                485                 490                 495     


Leu Ser Tyr Ala Ile His Met Ala Met Lys Glu Lys Gln Arg Ile Asp 
            500                 505                 510         


Asp Ala Val Lys Asp Tyr Leu Gln Asn Asn Phe Asp Leu Lys Pro Gly 
        515                 520                 525             


Ala Ala Asp Met Leu Tyr His Pro Ser Met Ile Glu Thr Tyr Pro Asp 
    530                 535                 540                 


Ala Gln Pro Asp Lys Asn Gly Val Val Leu Leu Gly Ser Pro Arg Thr 
545                 550                 555                 560 


Asn Ala Ile Lys Asn Pro Met Ala Met Arg Ser Leu His Glu Ile Arg 
                565                 570                 575     


Lys Val Ile Asn Thr Leu Ile Lys Glu Gly Lys Val Ala Pro Asp Thr 
            580                 585                 590         


Glu Ile His Ile Glu Tyr Ala Arg Glu Leu Asn Asn Ala Asn Met Arg 
        595                 600                 605             


Ala Ala Ile His Asp Leu Gln Arg Glu Lys Asp Lys Lys His Lys Glu 
    610                 615                 620                 


Tyr Ser Glu Asn Ile Arg Lys Leu Tyr Lys Glu Ala Thr Gly Lys Asp 
625                 630                 635                 640 


Ile Glu Ala Thr Glu Thr Asp Ile Leu Lys Phe Gln Leu Trp Glu Glu 
                645                 650                 655     


Gln Gly His Ile Cys Leu Tyr Thr Gly Asp Glu Ile Gly Ile Ala Asp 
            660                 665                 670         


Phe Ile Gly Ala Asn Pro Ser Phe Asp Ile Glu His Thr Ile Pro Arg 
        675                 680                 685             


Ser Val Gly Gly Asp Ser Thr Gln Met Asn Met Thr Leu Cys Asn Thr 
    690                 695                 700                 


His Tyr Asn Arg Phe Val Lys Lys Ala Tyr Ile Pro Thr Gln Leu Ala 
705                 710                 715                 720 


Asp His Glu Phe Ile Met Thr Arg Ile Glu Pro Trp Lys Glu Lys Ile 
                725                 730                 735     


Glu Asp Leu Thr Lys Gln Ile Asn Gln Ile Arg Thr Ser Asn Ile Trp 
            740                 745                 750         


Asp Lys Ala Ala Lys Asp Ala Lys Ile Arg Lys Lys Asn Arg Leu Leu 
        755                 760                 765             


Glu Glu Leu Lys Tyr Trp Lys Gly Lys Tyr Asp Arg Phe Thr Met Thr 
    770                 775                 780                 


Glu Val Pro Glu Gly Phe Ala Arg Arg Gln Gly Ala Gly Ile Gly Leu 
785                 790                 795                 800 


Ile Ser Lys Tyr Ala Ala Leu Tyr Leu Lys Ser Tyr Phe His Asp Thr 
                805                 810                 815     


Leu His Pro Glu His Arg Gln Val Tyr Ser Ile Lys Gly Thr Ile Thr 
            820                 825                 830         


Ser Asp Phe Arg Lys Met Trp Gly Ile Gln Glu Glu Asp Glu Lys Lys 
        835                 840                 845             


Ser Arg Asp Ser His Thr His His Cys Ile Asp Ala Ile Val Ile Ala 
    850                 855                 860                 


Cys Ile Gly Lys Asn Glu Phe Asn Met Met Gly Gln Tyr Tyr His Val 
865                 870                 875                 880 


Gln Glu Lys Phe Glu Lys Gly Glu Gly Glu Lys Pro Glu Phe Lys Lys 
                885                 890                 895     


Pro Trp Pro Thr Phe Thr Gln Asp Leu Lys Lys Ile Lys Glu Glu Leu 
            900                 905                 910         


Val Val Val His Asp Thr Pro Asp Asn Met Pro Lys Lys Ala Thr Lys 
        915                 920                 925             


Thr Ile Glu Ile Ser Lys Gly Arg Lys Val Val Ala Lys Gly Asp Cys 
    930                 935                 940                 


Ala Arg Gly Ser Leu His Gln Asp Thr Tyr Tyr Gly Ala Ile Glu Arg 
945                 950                 955                 960 


Asp Gly Asn Ile Lys Tyr Val Val Arg Lys Pro Leu Ser Ser Phe Thr 
                965                 970                 975     


Ser Ile Lys Asp Leu Asp Asn Ile Val Asp Asp Ala Val Arg Gln Ala 
            980                 985                 990         


Ile Leu Asn Ala Ile Glu Gly Lys  Asp Phe Lys Lys Ala  Leu Ala Glu 
        995                 1000                 1005             


Pro Ile  Tyr Met Asn Lys Asp  Lys Gly Ile Leu Ile  Lys Lys Val 
    1010                 1015                 1020             


Arg Cys  Tyr Thr Pro Ser Ile  Thr Lys Pro Leu His  Ile Arg Thr 
    1025                 1030                 1035             


His Arg  Asp Ile Ser Gln Lys  Glu Tyr Lys Gln Gln  Phe His Val 
    1040                 1045                 1050             


Ala Leu  Asp Ser Asn Tyr Cys  Met Ala Ile Tyr Glu  Gly Glu Val 
    1055                 1060                 1065             


Lys Gly  Lys Thr Lys Arg Thr  Tyr Glu Ile Ile Asn  Met Leu Asp 
    1070                 1075                 1080             


Ala Ala  Ala Tyr Phe Lys Lys  Ser Ser Asn Leu Ala  Lys Gln His 
    1085                 1090                 1095             


Pro Ile  Ala Pro Glu Asn Lys  Asn Glu Leu Lys Tyr  Arg Cys Ser 
    1100                 1105                 1110             


Val His  Thr Gly Thr Gln Val  Leu Leu Leu Gln Ser  Asp Gly Glu 
    1115                 1120                 1125             


Asn Ile  Asn Leu Glu Asn Lys  Asp Asp Ile Ala Arg  Arg Leu Tyr 
    1130                 1135                 1140             


His Val  Ala Val Met Arg Ser  Asp Gly Arg Ile Val  Leu Arg Tyr 
    1145                 1150                 1155             


Asn Gln  Asp Ala Arg Asp Ala  Thr Thr Leu Lys Lys  Glu Arg Lys 
    1160                 1165                 1170             


Ser Gly  Ala Tyr Lys Val Gly  Glu Gln Tyr Arg Ser  Glu Ile Met 
    1175                 1180                 1185             


Leu Ser  Leu Ser Asp Phe His  Ala Leu Val Glu Gly  Tyr Asp Phe 
    1190                 1195                 1200             


Thr Ile  Thr Pro Leu Gly Glu  Ile Lys Leu Lys His  
    1205                 1210                 1215 


<210>  1549
<211>  1350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OMNI-237 amino acid sequence

<400>  1549

Met Gly Asn Gln Ser Gly Gln Glu Tyr Tyr Leu Gly Leu Asp Ile Gly 
1               5                   10                  15      


Thr Asp Ser Ala Gly Trp Ala Val Thr Asp Pro Glu Tyr Arg Ile Leu 
            20                  25                  30          


Arg Arg Lys Gly Lys Ser Leu Trp Gly Val Arg Leu Phe Glu Ser Ala 
        35                  40                  45              


Asn Thr Ala Ala Glu Arg Arg Ala Phe Arg Thr Asn Arg Arg Arg Leu 
    50                  55                  60                  


Gln Arg Arg Arg Gln Arg Ile Leu Leu Leu Gln Glu Leu Phe Ala Glu 
65                  70                  75                  80  


Glu Met Glu Lys Val Asp Ala Gly Phe Phe Gln Arg Leu Asn Asp Ser 
                85                  90                  95      


Ala Cys Trp Ala Glu Glu Lys Glu Glu Pro Gln Ile Tyr Ser Leu Phe 
            100                 105                 110         


Gly Gly Lys Asp Tyr Thr Asp Val Asp Tyr Tyr Arg Glu Tyr Pro Thr 
        115                 120                 125             


Ile Tyr His Leu Arg Ser Ala Leu Leu Arg Gly Lys Gln Glu Tyr Asp 
    130                 135                 140                 


Leu Arg Leu Val Tyr Leu Ala Leu His His Leu Met Lys His Arg Gly 
145                 150                 155                 160 


His Phe Leu Phe Gln Gly Asn Ile Glu Ser Val Thr Ser Phe Gln Thr 
                165                 170                 175     


Thr Phe Gln Asn Phe Gln Asp Cys Leu Met Asp Glu Phe Gly Leu Glu 
            180                 185                 190         


Leu Glu Cys Asp Ser Glu Glu Arg Phe Ser Glu Leu Leu Lys Asp Arg 
        195                 200                 205             


Lys Ile Gly Arg Met Glu Lys Cys Arg Gln Leu Glu Leu Leu Cys His 
    210                 215                 220                 


Val Gln Lys Thr Asp Lys Gln Lys Lys Glu Ile Phe Lys Leu Ile Thr 
225                 230                 235                 240 


Gly Met Lys Ala Gly Leu Ser Val Ile Phe Ala Asp Glu Glu Leu Ala 
                245                 250                 255     


Gln Ile Asp Tyr Asn Lys Ile Ser Phe Ala Glu Ser Gly Tyr Glu Glu 
            260                 265                 270         


Ala Arg Leu Ala Leu Glu Glu Glu Ile Gln Glu Arg Thr Gly Ile Leu 
        275                 280                 285             


Asp Val Phe His Ala Val Tyr Ser Trp Ala Val Leu Ala Asp Ile Leu 
    290                 295                 300                 


Ala Gly Gly Glu Tyr Glu Gly Arg Pro Cys Leu Cys Val Ala Lys Val 
305                 310                 315                 320 


Asn Thr Tyr Glu Lys His Arg Gln Asp Leu Arg Leu Leu Lys Lys Leu 
                325                 330                 335     


Val Arg Glu Tyr Cys Pro Glu Asp Tyr Lys Ser Trp Phe Ser Val Pro 
            340                 345                 350         


Val Asn Asp Asn Tyr Cys Ala Tyr Ile Gly Thr Phe Arg Lys Asn Gly 
        355                 360                 365             


Lys Arg Cys Glu Thr Lys Arg Cys Asn Gln Glu Thr Phe Tyr Lys Ala 
    370                 375                 380                 


Leu Lys Lys Leu Leu Gly Lys Met Ser Ala Asp Leu Pro Glu Ala Ala 
385                 390                 395                 400 


Asp Ile Leu Lys Glu Thr Glu Asn Gly Thr Phe Leu Pro Leu Gln Val 
                405                 410                 415     


Ser Lys Asp Asn Gly Val Ile Pro Tyr Gln Val His Lys Met Glu Leu 
            420                 425                 430         


Glu Arg Ile Leu Asp His Ala Glu Lys Tyr Leu Pro Phe Leu Leu Glu 
        435                 440                 445             


Lys Asp Pro Glu Cys Gly Lys Thr Val Arg Glu Lys Ile Val Ala Leu 
    450                 455                 460                 


Phe Glu Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asn Thr Ala Ala 
465                 470                 475                 480 


Gly Glu Asn Cys Trp Met Glu Arg Lys Glu Glu Gly Ala Val Arg Pro 
                485                 490                 495     


Trp Asn Phe Asp Gln Lys Val Asp Arg Asp Lys Ser Ala Glu Arg Phe 
            500                 505                 510         


Ile Arg Arg Met Thr Asn Gln Cys Thr Tyr Leu Ile His Glu Thr Val 
        515                 520                 525             


Leu Pro Lys His Ser Leu Leu Tyr Ser Glu Phe Met Val Leu Asn Glu 
    530                 535                 540                 


Leu Asn Asn Val Lys Ile Arg Asp Glu Lys Leu Pro Val Glu Leu Lys 
545                 550                 555                 560 


Gln Gly Ile Val Gln Lys Leu Phe Lys Thr Arg Lys Gln Val Thr Gly 
                565                 570                 575     


Arg Lys Leu Leu Asp Tyr Leu Thr Ala Asn Gly Tyr Asp Val Lys Lys 
            580                 585                 590         


Asp Glu Leu Ser Gly Phe Asp Gly Asn Phe Lys Ala Ser Leu Thr Ser 
        595                 600                 605             


Tyr His Thr Leu Lys Lys Ile Phe Gly Lys Glu Leu Glu Lys Ser Ser 
    610                 615                 620                 


Val Gln Gln Met Ala Glu Asp Ile Ile Leu Trp Ile Thr Leu Tyr Gly 
625                 630                 635                 640 


Glu Asp Gln Lys Met Leu Cys Arg Val Ile Arg Gln His Tyr Gly Glu 
                645                 650                 655     


Ile Leu Lys Glu Glu Gln Leu Lys Glu Leu Ser Arg Leu Lys Phe Gln 
            660                 665                 670         


Gly Trp Gly Arg Leu Ser Arg Arg Phe Leu Asn Glu Leu Glu Gly Val 
        675                 680                 685             


Asp Cys Thr Thr Gly Glu Cys Met Thr Ile Met Gln Gly Leu Arg Asn 
    690                 695                 700                 


Thr Gln Asn Asn Leu Met Gln Leu Leu Ser Gln Gln Tyr Thr Phe Ala 
705                 710                 715                 720 


Arg Met Ile Asp Asp Glu Asn Gly Gly Tyr His Val Asp Glu Ile Thr 
                725                 730                 735     


Tyr Asp Asn Leu Val Lys Asp Ile Val Ala Ser Pro Ser Ile Lys Arg 
            740                 745                 750         


Ala Val Trp Gln Thr Ile Gln Ile Val Glu Glu Leu Lys Asn Val Met 
        755                 760                 765             


Gly Cys Glu Pro Lys Lys Val Phe Val Glu Met Ala Arg Gly Glu Glu 
    770                 775                 780                 


Glu Lys Arg Arg Thr Val Ser Arg Lys Asp Lys Leu Leu Glu Ala Tyr 
785                 790                 795                 800 


Ala Ala Ile Lys Asp Glu Ala Arg Asp Trp Gln Glu Glu Leu Gln Lys 
                805                 810                 815     


Tyr Ser Glu Gly Asp Leu Lys Ala Ile Lys Leu Tyr Leu Tyr Tyr Thr 
            820                 825                 830         


Gln Met Gly Gln Cys Met Tyr Thr Gly Lys Lys Ile Glu Leu Ser Gln 
        835                 840                 845             


Leu Asn Asn Ala Thr Ile Trp Asp Arg Asp His Ile Tyr Pro Gln Ser 
    850                 855                 860                 


Lys Thr Lys Asp Asp Ser Leu Asp Asn Leu Val Leu Val Asp Arg Arg 
865                 870                 875                 880 


Val Asn Ala Lys Lys Ser Asp Gly Met Ile Ser Pro Glu Ile Gln Gln 
                885                 890                 895     


Lys Met Arg Gly Thr Trp Lys Tyr Leu Lys Glu Lys Gly Leu Ile Ser 
            900                 905                 910         


Glu Lys Lys Tyr Glu Arg Leu Thr Arg Thr Thr Pro Leu Thr Glu Glu 
        915                 920                 925             


Glu Leu Ala Gly Phe Ile Asn Arg Gln Leu Val Glu Thr Arg Gln Ser 
    930                 935                 940                 


Ser Lys Val Val Ala Thr Leu Leu Lys Arg Ile Tyr Glu Glu Ala Glu 
945                 950                 955                 960 


Ile Val Tyr Val Lys Ala Lys Ala Val Ser Asp Phe Arg Lys Glu His 
                965                 970                 975     


Leu Lys Tyr Val Lys Val Arg Asp Leu Asn Asp Tyr His His Ala Lys 
            980                 985                 990         


Asp Ala Tyr Gln Asn Ile Val Val  Gly Asn Val Tyr His  Thr Lys Phe 
        995                 1000                 1005             


Thr Gly  Asn Pro Leu Arg Trp  Leu Lys Glu His Pro  Glu Arg Lys 
    1010                 1015                 1020             


Tyr Ser  Leu Asn Gln Met Phe  Asn Tyr Asp Leu Glu  Val His Gly 
    1025                 1030                 1035             


Lys Pro  Val Trp Lys Arg Gly  Lys Asp Gly Ser Ile  Arg Cys Val 
    1040                 1045                 1050             


Ser Glu  Thr Leu Lys Arg Asn  Asp Ile Leu Phe Thr  Arg Tyr Ala 
    1055                 1060                 1065             


Phe Cys  Asn Lys Gly Gly Leu  Phe Asn Gln Thr Ile  Met Lys Ala 
    1070                 1075                 1080             


Pro Glu  Asp Lys Ala Lys Ala  Lys Gly Leu Val Pro  Ile Lys Lys 
    1085                 1090                 1095             


Gly Lys  Asn Pro Glu Lys Tyr  Gly Gly Phe Thr Ser  Val Thr Pro 
    1100                 1105                 1110             


Ser His  Phe Met Leu Val Ala  Ser Glu Gly Lys Lys  Gly Lys Glu 
    1115                 1120                 1125             


Ile Arg  Thr Ile Glu Thr Val  Pro Leu Tyr Arg Lys  Lys Glu Phe 
    1130                 1135                 1140             


Glu Arg  Glu Pro Glu Leu Leu  Leu Gln Tyr Cys Arg  Glu Phe Tyr 
    1145                 1150                 1155             


Gly Leu  Lys Asn Pro Arg Ile  Leu Ile Ser Cys Ile  Lys Lys Asn 
    1160                 1165                 1170             


Ala Arg  Leu Val Ile Asn Gly  Phe Pro Met His Leu  Lys Gly Ser 
    1175                 1180                 1185             


Thr Gly  Lys Gln Leu Ile Leu  Gln Gly Ala Val Gln  Leu Cys Leu 
    1190                 1195                 1200             


Asp Asp  Glu Lys Val Val Tyr  Leu Lys Lys Val Thr  Asn Tyr Leu 
    1205                 1210                 1215             


Glu Glu  Asn Ala Arg Arg Lys  Asp Lys Arg Thr Leu  Leu Glu Val 
    1220                 1225                 1230             


Lys Glu  Ile Thr Gly Ile Thr  Ser Glu Ala Asn Ile  Asn Leu Tyr 
    1235                 1240                 1245             


Asp Leu  Phe Ile Lys Lys Leu  Ser Ser Thr Ile Tyr  Gln Tyr Arg 
    1250                 1255                 1260             


Pro Ala  Asn Pro Lys Asp Asn  Leu Leu Lys Gly Arg  Glu Lys Phe 
    1265                 1270                 1275             


Leu Asn  Leu Gly Leu Ala Glu  Gln Cys Val Val Leu  Gly Glu Ile 
    1280                 1285                 1290             


Leu His  Leu Phe Gln Cys Lys  Pro Leu Ser Ala Asn  Leu Ile Leu 
    1295                 1300                 1305             


Ile Gly  Ala Ala Gly Asn Thr  Gly Val Thr Lys Ile  Gly Lys Glu 
    1310                 1315                 1320             


Ile Ser  Arg Cys Asn Ser Ala  Lys Leu Val Ser Gln  Ser Val Thr 
    1325                 1330                 1335             


Gly Ile  Tyr Glu Gln Val Val  Asp Leu Leu Thr Ile  
    1340                 1345                 1350 


<210>  1550
<211>  1078
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OMNI-291 amino acid sequence

<400>  1550

Met Gln Trp Pro Tyr Gly Val Gly Leu Asp Ile Gly Val Ala Ser Ile 
1               5                   10                  15      


Gly Trp Ala Thr Val Ala Leu Asp Glu Lys Ala Gln Pro Cys Gly Leu 
            20                  25                  30          


Ile Arg Leu Gly Ser Arg Val Phe Lys Arg Ala Glu Gln Pro Lys Thr 
        35                  40                  45              


Gly Glu Ser Leu Ala Ala Pro Arg Arg Glu Ala Arg Gly Met Arg Arg 
    50                  55                  60                  


Arg Leu Arg Arg Arg Ala Leu Arg Lys Gln Asp Phe Tyr Gln Leu Leu 
65                  70                  75                  80  


Glu Lys Asn His Leu Pro Asp Lys Glu Glu Leu Ser Arg Leu Phe Ala 
                85                  90                  95      


Ala Gly Gly Leu Glu Asp Ile Tyr Ala Leu Arg Thr Arg Ala Leu Asp 
            100                 105                 110         


Glu Ala Val Thr Pro Gln Glu Phe Ala Arg Ile Leu Leu His Leu Met 
        115                 120                 125             


Gln Arg Arg Gly Phe Lys Ser Asn Arg Leu Ala Gly Lys Ser Lys Lys 
    130                 135                 140                 


Asp Gly Val Leu Leu Gln Ala Val Thr Gln Asn Gln Leu Arg Met Gln 
145                 150                 155                 160 


Glu Asn Gly Tyr Arg Thr Val Gly Glu Met Leu Tyr Lys Asp Pro Leu 
                165                 170                 175     


Phe Ala Ala Cys Lys Arg Asn Lys Gly Glu Asn Tyr Leu Ser Thr Val 
            180                 185                 190         


Ser Arg Glu Glu Ile Ala Asn Glu Ala Gln Leu Leu Phe Glu Ala Gln 
        195                 200                 205             


Arg Glu Lys Gly Arg Asp Trp Ala Thr Pro Glu Leu Glu Ala Glu Tyr 
    210                 215                 220                 


Leu Ser Ile Leu Leu Arg Gln Arg Ser Phe Asp Gln Gly Pro Gly Gly 
225                 230                 235                 240 


Asn Ser Pro Tyr Lys Gly Gly Trp Ala Glu Arg Val Gly Pro Cys Thr 
                245                 250                 255     


Leu Leu Pro Glu Glu Lys Arg Ala Phe Lys Asn Thr Tyr Ser Phe Glu 
            260                 265                 270         


Arg Phe Thr Leu Leu Gln Lys Ile Asn Asn Ile Arg Ile Val Glu Ser 
        275                 280                 285             


Gly Gln Thr Gln Ala Leu Ser Asp Glu Glu Arg Gln Lys Val Met Asp 
    290                 295                 300                 


Leu Ala Tyr Arg Val Glu Thr Val Pro Tyr Thr Leu Ile Arg Lys Glu 
305                 310                 315                 320 


Leu Gln Trp Pro Gln Thr Ile Arg Phe Ala Asp Val Arg Tyr Asp Val 
                325                 330                 335     


Asp Ala Ala Pro Glu Ala Ala Glu Lys Lys Cys Lys Leu Pro Pro Met 
            340                 345                 350         


Lys Gly Tyr His Ala Leu Arg Lys Ala Leu Gly Thr Arg Gln Ala Glu 
        355                 360                 365             


Leu Pro Leu Trp Asp Asp Val Ile Thr Ile Leu Ala Ser His Arg Asp 
    370                 375                 380                 


Glu Gly Val Arg Lys Lys Leu Leu Glu Glu Lys Gly Leu Thr Ala Glu 
385                 390                 395                 400 


Gln Val Glu Ala Val Leu Gly Leu Glu Phe Ser Gly Val Gly His Ile 
                405                 410                 415     


Ser Leu Lys Ala Cys Gln Met Leu Glu Pro Trp Leu Leu Gln Gly Leu 
            420                 425                 430         


Lys Tyr Asp Gln Ala Cys Ser Lys Ala Gly Leu Asp Phe Arg Gly His 
        435                 440                 445             


Ser Asn Ile Lys Lys Thr Pro Lys Leu Pro Ala Ser Ala Pro Glu Leu 
    450                 455                 460                 


Lys Asp Ile Thr Ser Pro Val Val Arg Arg Ala Val Ser Gln Thr Ile 
465                 470                 475                 480 


Lys Leu Val Asn Ala Ile Ile Arg Glu Met Glu Gln Pro Pro Val Trp 
                485                 490                 495     


Ile His Ile Glu Leu Ala Arg Glu Leu Ser Arg Thr Phe Glu Glu Arg 
            500                 505                 510         


Arg Arg Asp Gln Lys Ser Met Glu Asp Asn Ala Arg Gln Asn Glu Cys 
        515                 520                 525             


Leu Met Gln Glu Ile Arg Asp Thr Phe His Lys Leu Asn Pro Thr Gly 
    530                 535                 540                 


Gln Asp Leu Ile Lys Tyr Arg Leu Trp Lys Glu Gln Asp Gly Ile Cys 
545                 550                 555                 560 


Ala Tyr Ser Gln Gln Ser Ile Ala Val Glu Arg Leu Phe Glu Thr Gly 
                565                 570                 575     


Tyr Ala Glu Val Asp His Ile Val Pro Tyr Ser Ile Ser Phe Asp Asp 
            580                 585                 590         


Ser Arg Ser Asn Lys Val Leu Val Met Ala Ala Glu Asn His Gln Lys 
        595                 600                 605             


Gly Asn Arg Leu Pro Leu Gln Tyr Leu Gln Gly Glu Arg Arg Glu Lys 
    610                 615                 620                 


Phe Ile Val Trp Thr Lys Ser Gln Val Arg Asn Tyr Arg Lys Gln Lys 
625                 630                 635                 640 


Asn Leu Leu Arg Glu Thr Val Ser Glu Glu Glu Gln Asn Gly Phe Lys 
                645                 650                 655     


Gln Arg Asn Leu Gln Asp Thr Gln Tyr Met Ala Arg Phe Leu Leu Asn 
            660                 665                 670         


Tyr Ile Arg Asp His Leu Ala Phe Ala Asp His Pro Ala Ala Gly Lys 
        675                 680                 685             


Gln Arg Val Met Ala Leu Ala Gly Ala Val Thr Ser His Leu Arg Lys 
    690                 695                 700                 


Arg Trp Gly Leu Thr Lys Val Arg Ala Asp Gly Asp Leu His His Ala 
705                 710                 715                 720 


Leu Asp Ala Ala Val Ile Ala Cys Ala Thr Lys Gly Met Val Gln Gln 
                725                 730                 735     


Ile Ser Gly Tyr Tyr His Arg Ile Glu Gly Glu Tyr Gln Gln Ser Ser 
            740                 745                 750         


Asp Gly Thr Tyr Ser Val His Thr Arg Thr Gly Glu Val Phe Pro Ala 
        755                 760                 765             


Pro Trp Pro His Phe Arg Asp Glu Leu Ile Gln Arg Leu Ser Gln Lys 
    770                 775                 780                 


Pro Gln Glu Asn Leu Met Gln Trp Asn Pro Val Phe Tyr Ser Asn Phe 
785                 790                 795                 800 


Asp Val Glu Ser Ile Arg Pro Val Phe Val Ser Arg Met Pro Gln His 
                805                 810                 815     


Lys Val Thr Gly Ala Ala His Lys Glu Thr Ile Lys Ser Pro Lys Ala 
            820                 825                 830         


Leu Gln Asp Gly Leu Leu Ile Val Lys His Pro Leu Thr Asp Leu Lys 
        835                 840                 845             


Leu Asn Lys Lys Thr Gly Glu Ile Glu Gly Tyr Tyr Gln Pro Ser Ser 
    850                 855                 860                 


Asp Lys Leu Leu Tyr Glu Ala Leu Arg Ala Arg Leu Leu Glu Phe Gly 
865                 870                 875                 880 


Gly Asp Gly Lys Lys Ala Phe Thr Glu Pro Phe Tyr Lys Pro Lys Ser 
                885                 890                 895     


Asp Gly Thr Pro Gly Pro Leu Val Arg Lys Val Lys Leu Cys Glu Lys 
            900                 905                 910         


Ala Ser Leu Cys Val Pro Val His Gly Gly Asn Gly Ala Ala Asp Asn 
        915                 920                 925             


Asp Ser Met Val Arg Val Asp Val Phe Phe Val Pro Gly Asp Gly Tyr 
    930                 935                 940                 


Tyr Met Val Pro Ile Tyr Val Ser Asp Thr Lys Lys Lys Glu Leu Pro 
945                 950                 955                 960 


Asn Arg Ala Val Val Ala His Lys Glu Phe Ser Ala Trp Lys Val Met 
                965                 970                 975     


Glu Glu Lys Asn Phe Leu Phe Ser Leu Tyr Ala Asp Asp Leu Ile Glu 
            980                 985                 990         


Val Ala Arg Lys Lys Val Met Pro  Phe Thr Ile Val Asn  Ser Gly Ser 
        995                 1000                 1005             


Thr Leu  Pro Pro Ser Tyr Glu  Thr Thr His Glu Met  Val Tyr Tyr 
    1010                 1015                 1020             


Gly Gly  Leu Asp Ile Ser Ser  Gly Asn Ile Lys Val  Thr Ile His 
    1025                 1030                 1035             


Asp Asn  Ser Tyr Ser Leu Arg  Gly Leu Gly Ile Lys  Thr Leu Asn 
    1040                 1045                 1050             


Thr Leu  Gln Lys Tyr Glu Val  Asp Ile Leu Gly Asn  Val Arg Glu 
    1055                 1060                 1065             


Val Lys  Lys Glu Lys Arg Gln  Ser Phe Arg 
    1070                 1075             


<210>  1551
<211>  1097
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OMNI-308 amino acid sequence

<400>  1551

Met Ala Tyr Ala Ile Gly Leu Asp Ile Gly Ile Ala Ser Val Gly Tyr 
1               5                   10                  15      


Ala Val Val Ala Leu Asp Tyr Glu Glu Asn Pro Trp Gly Ile Ile Asn 
            20                  25                  30          


Met Gly Ser Arg Ile Phe Asp Ala Ala Glu Asn Pro Lys Asp Gly Ala 
        35                  40                  45              


Ser Leu Ala Ala Pro Arg Arg Glu Ala Arg Thr Gly Arg Arg Arg Leu 
    50                  55                  60                  


Arg Arg Arg Lys His Arg Ile Glu Arg Ile Lys Asn Leu Phe Leu Asn 
65                  70                  75                  80  


Thr Gln Leu Leu Thr Lys Glu Gln Leu Glu Lys Leu Tyr Glu Gly Val 
                85                  90                  95      


Leu Ser Asp Val Tyr Glu Leu Arg Val Lys Gly Leu Asp Glu Lys Leu 
            100                 105                 110         


Thr Ala Glu Glu Val Ala Arg Val Leu Leu His Leu Ala His Arg Arg 
        115                 120                 125             


Gly Phe Lys Ser Asn Arg Lys Ala Glu Lys Thr Asp Lys Glu Asn Gly 
    130                 135                 140                 


Ala Leu Leu Thr Ala Val Ser Glu Asn Gln Lys Arg Met Lys Asp Lys 
145                 150                 155                 160 


Gln Tyr Arg Thr Ile Gly Glu Met Phe His Lys Asp Glu Leu Phe Ala 
                165                 170                 175     


Glu Tyr Lys Arg Asn Lys Gly Gly Thr Tyr Leu Thr Thr Val Ala Arg 
            180                 185                 190         


Glu Met Ile Ala Asp Glu Ala Lys Tyr Ile Ile Ala Thr Gln Arg Ser 
        195                 200                 205             


Phe Gly Asn Lys Thr Leu Thr Ile Glu Phe Glu Glu Ser Tyr Leu Asp 
    210                 215                 220                 


Ile Leu Leu Ser Gln Arg Asn Phe Asp Glu Gly Pro Gly Gly Asn Ser 
225                 230                 235                 240 


Pro Tyr Gly Gly Asp Gln Ile Glu Arg Met Ile Gly Asn Cys Thr Phe 
                245                 250                 255     


Glu Lys Ser Glu Lys Arg Cys Ala Lys Ser Cys Tyr Ser Phe Glu Tyr 
            260                 265                 270         


Phe Asn Leu Leu Gln Lys Ile Asn His Leu Arg Leu Leu Val Asp Gly 
        275                 280                 285             


Val Lys Val Glu Leu Asp Gly Ser Gln Lys Ser Lys Val Ile Asn Leu 
    290                 295                 300                 


Ala Lys Thr Lys Ala Asp Leu Lys Tyr Ser Gln Ile Arg Lys Glu Leu 
305                 310                 315                 320 


Gly Leu Gly Ser Gln Val Leu Phe Asn Ala Leu Val Tyr Asn Ser Asp 
                325                 330                 335     


Val Glu Glu Val Glu Lys Lys Ser Lys Phe Asn Phe Met Pro Ala Tyr 
            340                 345                 350         


His Gln Ile Arg Lys Glu Leu Asp Thr Val Val Lys Gly Arg Ile Glu 
        355                 360                 365             


Ala Ile Asp Ile Asp Thr Leu Asp Glu Ile Gly Arg Ile Leu Ser Thr 
    370                 375                 380                 


Tyr Lys Ser Asp Ala Lys Arg Ile Glu Ala Phe Ser Asn Leu Asn Ile 
385                 390                 395                 400 


Thr Ser Lys Asp Met Glu Ala Leu Leu Asn Ile Asn Gly Leu Arg Lys 
                405                 410                 415     


Phe Gly His Leu Ser Leu Lys Ala Leu Lys Lys Ile Thr Pro Phe Leu 
            420                 425                 430         


Glu Gln Gly Met Ile Tyr Asn Glu Ala Cys Thr Ala Ala Gly Tyr Glu 
        435                 440                 445             


Phe Arg Gly His Ser Gly Tyr Glu Lys Thr Phe Leu Leu Pro Ser Gln 
    450                 455                 460                 


Thr Glu Glu Met Glu Asn Val Thr Ser Pro Val Ala Arg Arg Ser Ile 
465                 470                 475                 480 


Ser Gln Ser Ile Lys Val Ile Asn Ala Ile Ile Arg Glu Gln Gly Glu 
                485                 490                 495     


Ser Pro Leu Tyr Ile Asn Val Glu Leu Ala Arg Glu Met Ala Lys Asp 
            500                 505                 510         


Phe Asp Glu Arg Lys Lys Ile Lys Lys Glu Thr Asp Glu Asn Gln Ala 
        515                 520                 525             


Arg Asn Glu Arg Leu Ile Glu Lys Ile Arg Asn Glu Phe His Lys Gln 
    530                 535                 540                 


Asn Pro Thr Gly Leu Asp Leu Val Lys Leu Lys Leu Trp Glu Glu Gln 
545                 550                 555                 560 


Asp Gly Val Ser Pro Tyr Ser Gln Lys Gln Ile Val Ile Glu Arg Leu 
                565                 570                 575     


Phe Glu Pro Gly Tyr Val Asp Val Asp His Ile Val Pro Tyr Ser Ile 
            580                 585                 590         


Ser Phe Asp Asp Thr Met Lys Asn Lys Val Leu Val Phe Ala Ser Glu 
        595                 600                 605             


Asn Arg Glu Lys Gly Lys Asn Leu Pro Val Glu Tyr Leu Ala Arg Lys 
    610                 615                 620                 


Lys Gly Gln Lys Ala Val Asp Asp Phe Lys Val Trp Val Thr Ser Asn 
625                 630                 635                 640 


Val Arg Asn Tyr Lys Lys Arg Leu Asn Leu Leu Lys Ser Glu Val Thr 
                645                 650                 655     


Glu Glu Asp Leu Asn Lys Phe Lys Glu Arg Asn Leu Gln Asp Thr Lys 
            660                 665                 670         


Thr Ile Ser Arg Phe Met Tyr Asn Tyr Ile Ser Asp His Leu Ile Phe 
        675                 680                 685             


Ala Pro Ser Glu Thr Gly Lys Lys Lys Arg Val Thr Ala Val Asn Gly 
    690                 695                 700                 


Ala Ile Thr Ser Tyr Leu Arg Lys Arg Trp Gly Ile Asn Lys Val Arg 
705                 710                 715                 720 


Ala Asp Gly Asp Lys His His Ala Val Asp Ala Leu Val Ile Ala Cys 
                725                 730                 735     


Thr Thr Asp Lys Leu Ile Lys Asp Leu Ser Tyr His Ser Arg Tyr Leu 
            740                 745                 750         


Glu Met Glu Tyr Glu Ala Gly Glu Lys Glu Ser Leu Trp Val Asn Arg 
        755                 760                 765             


Asn Thr Gly Glu Ile Val Lys Arg Phe Pro Tyr Pro Trp Glu Asp Phe 
    770                 775                 780                 


Arg Ala Glu Leu Met Ala Arg Leu Ser Asp Ala Pro Glu Val Ala Leu 
785                 790                 795                 800 


Arg Lys Leu Gln Leu Leu Tyr Tyr Gln Asp Lys Asp Leu Ser Lys Ile 
                805                 810                 815     


Lys Pro Ile Phe Val Ser Arg Met Pro Arg Arg Lys Ile Thr Gly Ala 
            820                 825                 830         


Ala His Lys Ala Thr Val Arg Gly Ala Arg Tyr Val Asp Lys Gly Ile 
        835                 840                 845             


Val Ile Ser Lys Lys Ser Leu Ser Glu Leu Lys Leu Asn Lys Gly Gly 
    850                 855                 860                 


Glu Ile Glu Asn Tyr Phe Ala Pro Glu Ser Asp Arg Leu Leu Tyr Glu 
865                 870                 875                 880 


Ala Leu Lys Glu Gln Leu Lys Lys Phe Asn Gly Asn Ala Lys Lys Ala 
                885                 890                 895     


Phe Glu Gln Gly Phe Tyr Lys Pro Lys Ala Asp Gly Thr Pro Gly Pro 
            900                 905                 910         


Lys Val Asn Lys Val Lys Val Tyr Asp Lys Ser Thr Leu Asn Val Ala 
        915                 920                 925             


Val Gln Gln Gly Thr Gly Ala Ala Asp Asn Asp Ser Met Val Arg Val 
    930                 935                 940                 


Asp Val Tyr Lys Val Glu Gly Asp Gly Tyr Tyr Leu Val Pro Ile Tyr 
945                 950                 955                 960 


Val Ala Asp Thr Leu Lys Lys Glu Leu Pro Asn Lys Ala Ile Val Gln 
                965                 970                 975     


Gly Lys Thr Tyr Glu Gln Trp Lys Glu Met Ser Pro Glu Asp Phe Val 
            980                 985                 990         


Phe Ser Leu Tyr Pro Asn Asp Leu  Ile Lys Ile Thr His  Lys Lys Glu 
        995                 1000                 1005             


Ile Asn  Phe Ser Arg Val Ser  Glu Asp Ser Thr Leu  Ala Asp Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Lys Glu Glu Phe  Val Tyr Tyr Lys Lys  Thr Ser Ile 
    1025                 1030                 1035             


Ser Thr  Ala Ser Ile Ser Ile  Ile Asn Asn Asp Asn  Thr Tyr Thr 
    1040                 1045                 1050             


Ile Pro  Ser Leu Gly Val Lys  Thr Leu Ala Ser Leu  Glu Lys Tyr 
    1055                 1060                 1065             


Gln Val  Asp Ile Leu Gly Asn  Tyr Thr Lys Val Gly  Lys Glu Lys 
    1070                 1075                 1080             


Leu Gln  Thr Phe Ala Ala Tyr  Gln Gln Ala Lys Lys  Lys Pro 
    1085                 1090                 1095         


<210>  1552
<211>  4047
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-103 DNA sequence

<400>  1552
atgagcataa aaagtgatta ttttttagga cttgatattg gtacggattc tattggatgg       60

gcggtaaccg acccagaata tcacatattg agacgaaaag gtaaagcatt atggggaata      120

agattatttg atgcggccaa tacagcggca gaacggcgaa catttaggac aagccgaaga      180

aggattcaga gaagacgaca gagaattcgg ttattgcaag aattatttgc agaagaaatg      240

gtaaaattag acccaggatt ttttcagagg ttgtcagaca gcgcattttg gcaggaggat      300

aagcaagagc agcaaattta ttcacttttt acttgtgaaa attatacaga tgttgattat      360

tacagagaat atcctactat ttatcatttg agaagtgcat tgattcagga aaagaaggaa      420

tttgatcttc gtcttctata tcttgctctt caccatttga tgaagcacag gggacatttc      480

ctgtttaatg ggagtattaa taatgtgacg tcatttcata cgacgtttca gacgtttgca      540

gattgtcttt atgatgagtt tgatatagaa ctggaatgtg attccgaaga tagatttgca      600

gaaattttaa aggataaaca tgccagaaaa acaggaaaat gttctgaatt agagataatc      660

tgtcatatag aaaaatcaaa taagcagcta aaagaacttt ttaaattaat tacaggaatg      720

aaagctagtt tgagtgttgt gtttggtgat gatgagttag cggaaataga acataataag      780

attagttttt cagagagtag ttatgatgaa gtacgtcttg cattggagga tgagattcag      840

gagaggactg gtatactgga tatctttcat gcagtttata gttgggcgat tctcgcggat      900

attttagaag gcggagaata tgaggggaat tcttatctaa gcgttgcgaa ggtaagcact      960

tataaaaagc atggtgatga tttgcggttg ctaagaacac tggttcggga atattgtcct     1020

gatcattaca aatctttctt ttccgtatca gggaaggaga attattgtgc atatgcgggt     1080

actttaaaaa agaatggaaa aaaacagccg attaaacgtt gcagccagga agatttttat     1140

aaagcgttaa agaaattgct gaatcagatg ccgacagaac aaccagaagt gaaagacatc     1200

ttcatcgaaa ttgaaaatgg tacttttttg ccgttgcagg taagtaagga taatggagtg     1260

ataccttatc aggtaaataa gatggaatta gaaaaaatcc tgcagaatgc agaggaatat     1320

ttgccatttc taaaaaatat agatgaagaa tgtggaaaaa cggttagtaa gaagattata     1380

gatctctttg agtttagaat accatattat gtagggccgc ttaataccgc taaaggagaa     1440

aactgttgga tggtcagaaa agaagcgggg agaatatatc cgtggaattt tgatgaaaag     1500

gtagacagag atcaatcagc agaaaaattt atccgtagaa tgacgaatca gtgtacatat     1560

ttaatacatg aggatgttgt acctaaaaat tctttgcttt attcggagtt tatggtgctt     1620

aatgaattaa ataatgtaaa gatccggtct gagaagctgc cggtggagtt aaaacaggca     1680

atagtattgg atttgtttaa gaaacaaaag cagataacag gaaaaaaact tcttaattac     1740

ttgaatgcaa atggatatga tgtaaaaaaa gaagatttgt cagggtttga cggaaacttt     1800

aaatcatctc tgtcatcata tcttactttg aaaaaagtat ttggtgaaga attagataaa     1860

tatagtgtgc agcagatggc agaggatatt atcttgtgga tcactctgta tggagatgat     1920

cagaagatgt tgcgcagggt aattcgaaaa cattatgaac agcaattgag tgaagaacag     1980

attctttcct tatcgaaatt gaaattccaa ggctggggaa gattatccag acgacttttg     2040

agtgaaatgg aaggcgttga ttgtgagact ggtgagtgta tgacggtcat gcaaggactt     2100

cgtaatactc agaataatct gatgcagctt ctaagtcagc agttttcatt tatggaattg     2160

attgaggaag aaaatgggaa ttattatgta gatgagatta catacgataa tcttgtgaaa     2220

gatatggtta tatctccgtc agtgaagaga gcagtctggc agacagttca gattgtggag     2280

gagattaagg gggtaatggg ctgtcagcct aagaagatat ttgtcgagat ggcgcgaagc     2340

gatgaagaga aaaagcgtac tgtatctagg aaagacaggt tattagaagc atatgatgcg     2400

atcaaggatg aggctcgtca atggcaggaa gagttgcaaa agtattcaga tggtgatttt     2460

aaggctatta aactttatct gtattatacg cagatggggc aatgtatgta tactggaaga     2520

aagatagatc tgtcacaatt aaatgatgcg acggtatggg acagagatca tatatatcca     2580

cagtccaaaa caaaagatga tagtctggat aatctggtat tggtagaccg gagcgtgaac     2640

gctaagaaaa gtgatgggat gctatcacct gagattcagc agagaatgcg ggctacttgg     2700

aaatacttaa aagagaaaaa gttgatttca gagaagaaat atgagcgttt gactagggtc     2760

tcaccactta cagatgagga attggcaggt tttattaatc gacagttagt tgaaacacgt     2820

cagtcttcga aagcagtagc aacacttttg aaacgagtat atgatgaagc ggagattgtc     2880

tatgtaaaag cggaagctgt ttcaaatttt agaagagata atttggatta tattaaggtg     2940

cgtgatctga atgattatca tcatgctaaa gatgcatatc agaatattgt agtggggaat     3000

gtttttcatg agaaatttac cagcaatccg cttcgttggc tgaaaaacaa tcctaatacg     3060

aaatatagtt taaatcagat gtttaacttt gatttagaga aaaatggggt ggtaatatgg     3120

aaaaggggga aggctggaag tattaaatgt gttgaagaaa cattgaaaag aaatgatatt     3180

ctttttacac gatatgcttt ttgtaataaa ggtggttttt ttaaccagat gttaacggca     3240

gctccagaag ataaaacgaa agcaaaggga cttgtaccaa taaaaaaagg tatggaaaca     3300

tggaaatacg ggggatatac atcagtaact ccgtcacatt ttatgttggt tgcttcgaaa     3360

gataagaaag gaaaggagat aagaacgatt gagacagttc cgttgtatag gtggaaagag     3420

ttcaaagaaa atccagatgc attactccaa tattgtagag agttctatgg tttgaaagag     3480

cccaaggtgt tgataccatg catcaagaag aatgccagat tagtcgttaa tggatttcca     3540

atgcatttga aagggagtac aggaaaacaa ttgattttgc agggagcggt tcaattatgt     3600

ctgaataatg aaaatataaa gtatttgaaa aaagtcacaa aatatttgga atataatgca     3660

cagagaagag ataaaagaac actgctggaa gtaagagagg ttacaggaat taacaaagag     3720

gaaaatatac agttatatga tgtgtttgtt gataaattga gtaacacaat atatcagtat     3780

cgtccggcca atccaaagga caatcttata aaaggaagag agaagtttat agaattaggg     3840

ttggcagaac aatgtgttgt gttaggtgaa gtattgcatt tgttccaatg taaaccactc     3900

acgtctgatt tgactttgat tggaggttca ccgaatacag ggacaataaa aataacaaag     3960

acaattagta attgtaatgt tgtaaagttg ttaagccaat ctattgcagg tgttaaagtg     4020

agagaaatta atttgttaat aatatga                                         4047


<210>  1553
<211>  3294
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-124 DNA sequence

<400>  1553
atgggaaaga ttataggact agatattggg attgcatcag ttggttgggc agtgttagat       60

aaggatagtt ataagattgt tgaggctggg tctaatatat ttccggctgc ggaagcaagt      120

aagaatcaag aaagacgtga atttcgtggc ttgagaagga tgactagaag acgaagaacc      180

cgtttggatg attttaaaaa gctatggaag aactattata aaaatgagta ttcagtaaca      240

cctaataatg ttacagagtt aaaagtcaag ggattatcag aacagctatc agaattagaa      300

ttatacactg ttttatattc gtatttaaag catcgtggta tatcttattt agaggatgct      360

gttgatgaag ggaaaactgg aagtgattat ctaaaaggac ttcaaacaaa tcaaaaagag      420

atgaatacta aattcccaag tcagatccaa tatgaaagac tagagaaata tgggtgtttt      480

cgtggagaaa acaaggtgag tgatgatgag gtattgagta atgtttttac cacatcggca      540

tacaaaaaag aaattgaaga actgattagt gttcaggata atcttgggaa tgaattagat      600

aaagatttta taaaaaagta ttttgagata ttttcgagaa aaagaaaata ttatgaaggt      660

cctggaaatg aattatcaag aacagattat ggtatatata caactaaaat tgatgaaaat      720

ggcaattata tcactgataa aaaccttttt gaaaaattga ttggtaaatg ttctgtttat      780

cctgaagaaa tgagagcatc ggctgcatca tatactgctc aagagtttaa tgcattgaat      840

gacttaaata atcttatagt taatggcagg aaactaacta aagaggaaaa gataagtatt      900

attgaatgtt ataaaactga aaaaacaata aatgttagaa aaatcatcaa aaatgtgata      960

ggagagaata ttgatcaatt atccggatat agaatggata agaatgataa agaactttat     1020

cacacctttg aggtttataa taaactgaga aaagcctttg aagaggcggg aatcagcttt     1080

gatttttcac gtgaggattt tgatgaaata ggaagaattt taactttaaa tattgaaaga     1140

gaaggtatag aggatgctat tagaatcagt aatctggttt tatctagtga cgcagttgat     1200

gtactaatat ctgtaagaaa gaaaaatgct tctttattca gtaaatggca ttctttttct     1260

ttgaaaatta tgaatgagct cattccggaa atgtatgaac aaccaaagaa tcagatggaa     1320

ttattgtctg atatgaagtc aatcaagtcc aaaatggatg agtttaaagg cttagaagat     1380

attcctgtcg agactattat tgaggatata tacaaccctg tagtaaagag atccatcaga     1440

atcacaatca agataataaa tgcattaaag aaaaagtatt ctgatataga aaaaatcgta     1500

atcgaaatgc caagggataa gaattccgat gaagaaaagg agcgaatcaa aaagtttcag     1560

aaggatcaag aaaatgaatt gcccaatatt ataaaaagag taaaagatga gtatgggata     1620

acactgacgc cggagttgat agccagaaaa aaaggattgg cttttaaact taaattgtgg     1680

aatgaacaga atggaagatg tccgtattcc ggacgaatga ttgatataga aagcttgatt     1740

aatgatggtg atttgtttga agtggatcat ataataccac tctctatttc ttttgatgac     1800

agtagatcaa acaagacgct tgtgtacaga gtggaaaatc aggaaaagaa aaacaataca     1860

ccatttatgt atttgagtag attaaatcgt cagtggaatt atgataaatt tgcggctttt     1920

attaaagaat tgtatggtag ttccgggaaa gatagaaaaa aattcagaaa gaaaatgaat     1980

aattttttat ttacggaaga tataaataag attgacgtat taaaaggatt tattaataga     2040

aatataaatg acactcgcta tgcttcaaga gttgtactta attcattgca aggatacttt     2100

agagctaatg ataataacgt aaaggtgtcg gttataaatg gcagtttcac tcatcagatg     2160

cgtgttaatc tatcattagg gaaagataga gatgaatcct ttgctcatca tgctgtcgat     2220

gctatgttaa ttgctctgtc acaaatgggg tatgatgctt ttagagcgag acagaaggat     2280

atagtagatt ttgagactgg tgaaataatt aatggtagtg cctgggaaaa tcaggatgaa     2340

atgtataaga cagtcttata tcaggaaaaa tggaagaata taaaggataa tatcatagag     2400

gcagagccta atattaagta ttggcataag gtcgataaaa agtgtaacag gggactatgt     2460

aatcagacta tatattcaac cagaaaatgt gatgataaga tatggaaggt tgataaactg     2520

aatattcgag ataaggatga tgtaaaaaag ctgatctaca tgatacaaaa tggaaaagaa     2580

gataaaatac ttatggctca aaatgatcca aagacttttg ctaatctgaa gtatatttta     2640

gatgaatata gcgattgtga gaatccgttt gtatcttatg aaaaagaaac tggtgacctt     2700

gtaagaaagt attcaaagaa gcataatgga cctaaaataa catatttaaa atatatggtt     2760

gaggaggtta atagctgtat agatatatca cataagtacg ggcatgaaaa aggatcaaaa     2820

aaagtctttt tggctcaatt ggttccattt agaacagatg tctattacaa taataacagt     2880

ggtaaatact atctcatagg gataaagcag tcagatataa agtgcaaggg taatcagtac     2940

attattgatg aagaaaagta cacagataat ttgattcaaa atggtctttt aaaggaagga     3000

cagaaaatag aagatttaga gaaacttggc tatttattta aattttcaat ctttaaaaat     3060

gatactattg aattcgagaa gaagggagaa ttaatcaagt gtagattttt atctcaaaat     3120

tcggcatcta agaatagaat agaggtaaaa ccaatcggaa aaaaagatta tgaaagtaga     3180

aatttgccca cgctttcgac tacaacagtt attaataaat atgtaaagga tatattggga     3240

aatgaaaagc aagtaagtgg cgaaaaattt gaaataattg ttgattcaaa ataa           3294


<210>  1554
<211>  3330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-127 DNA sequence

<400>  1554
atgggaaaat tagtgttagg tttagacatt ggaattactt ctgtcgggta tggagtaatt       60

gatatagata ataataaatt tgtagattat ggagtaagac tttttaaaga aggtgattct      120

aacgacaatg aaaaaagaag atcatataga agtggaagaa gattaagaag aagaaaaaag      180

aatcgtttag atgatatgaa aagtcttctt ttgagtgcag gtatacttac aaaagactat      240

aaacctctta ataatattta tgaaattaga gtaaagggat taacagaaaa attaacaaac      300

aacgaattag ccgctgctct tcttcatatt acaaaaaata gagggactac tgtcgaagct      360

ctagaaactg ctgatgcaga taaagaagca gcaggaacca aagatgtatt agcaaagaac      420

gcaaaagatt tagagcaatt tgagtatgta tgtaaagtac agttatatcg tttagaaaaa      480

tatggaaata ttaggggaac agaaaataac tttaatactt ctgattatgt aaaagaggca      540

agagcaattt taaagtgtca agatatagat gtagaactat ctgaaagcat tgtaaatatc      600

ataagcagaa ggagagagta ttatgaagga cctggtagtg aaaaatctcc aacaaaatat      660

ggaagatgga tagaaaaagg agcagaacca atcgatctta tagagaaaat gagaggaaaa      720

tgttcaatat atcatgatga gcttcgagca ccaaaatcct catattctgc tgaattattt      780

aatttgttaa atgacttgaa taacctttca attaatggtg agaagttaac tcaaaatgaa      840

aaagaaatag ttatagaaga agtaaataat aatggaaaaa tcactataga taaattaaag      900

aaattattaa atattaatga tagtaaagat gttgtcgaag gattcagaat aaataaaagt      960

aatgagcttt tattaacgaa tatggcaatg tatgaccagt ttaaaaaaat ttttgataag     1020

cataaagagg atgcttatca aagggataag tatattattg atcaaattgc tgaaattaat     1080

acagctaaaa aaggtattaa agaaagatgt gatgcaattg aaaagcaatt ccctaatttt     1140

gattataatt taatcagaga tttagctgaa atgaaaaaaa tgacacagta tcattcatta     1200

tcattaaaag caattcgaga aataaataaa gagatgatta aaagtccgta taatcaaatg     1260

caggcaatcc atgaattagg attgcagcac tatagaaaat cttacaaagg aatgaagaaa     1320

attcaagttg atgaagaagc aatattatct ccagtagtta aaagagcaca aagagaaaca     1380

ttcaaagtaa ttaacagatt aagagaaata tatggtgaat ttgaatcaat agttgttgaa     1440

acaactagag ataaaaatag taaagaaaaa aaggaaagaa ttaacaaaac tcaaaaatac     1500

tatgaagata ggaacaaaaa agttgatgag ttgttaaaag agagaggata taatccagat     1560

actataaata ataaaacaaa gatgaaagtt aagctctatc ttgatcaaaa tggaaagagt     1620

gcatatacaa tgacacctct taaattaaat cttattatta ctaatcctca cgcatatgaa     1680

attgatcata ttattcctct ttcaatttct caagatgatt catttaataa taaagttctt     1740

attacacatg aagaaaacca ggttaaaggt aacaaaacac caatatatac ttatttaaat     1800

aatcagttta aaaattgtga tattaataaa tataaagaat cagtaaaaaa taatcataat     1860

ttttcacgaa agaaaaagtt ttatatgctc tatgaaaaag atattactaa gtattcaaat     1920

atgaaagaat ttatcgcaag aaacttagtt gatacaagtt atgcaagtag agtagttctt     1980

aatacattaa cctcatattt tagagataat gatatttcaa caaatgttca tacaattaga     2040

ggatcggcta caagtttata tagaaaaaga attggactaa aaaaagatag agataaagat     2100

tttcttcatc atgctattga tgctttaatt gttgcgtcaa taaaaaaaca atctattttt     2160

agaaaatatt taattaaata taatcttagt gaattgtata atgaaaaaac tggagaatta     2220

atcaaagttg aagaagacag taaagtaatt gatccagtat ttatagaatt tatttccaat     2280

ttgaaaacaa tttatgagca atcatatcaa tattacaatg gatatatttc tagaaataaa     2340

atgaaattta aaccaattaa aatttcccat aaggttgata caaaaccaaa tagaaaaatt     2400

tctgatgaaa caatctacag tacaagaaat gtaaatggtg tagaaagagt tgtaaaaaaa     2460

gttaaagaca tttatgatcc aaaatttgat aaactaacaa atgatattat taataatcaa     2520

tatcataata agtggataat ggctgaaaag gatgaacaga catttgaaat tattaaatca     2580

attgtgatgg cacattttaa tacttataaa gaagataagg acatatataa gagtaaatca     2640

aaaaaaggtg ttactacttg gtctttaaaa ggaagtaata atccattatc acagtttaaa     2700

gaagaacatg gaaaaatacg taaatattct aaaaaaggaa atgggcctga aattacttct     2760

atgaaatatt atgaagatga attaggaaat catgttaata tcacaaaaaa atataatgta     2820

gataataaaa atgtagtttt acttcagata agtccatata gaactgattt ctatgtttca     2880

ccaaaaggaa aatataaatt tgtaactata agatactgca atgttttcta taaagaatca     2940

aataaaaaat atttaattga taaaaaatgg tatgaagagg agaagaagaa aaagaaaatt     3000

gatgattcat atcaatttgt atgttctttg catcatgatg aaatattagg agttaaatta     3060

gaagatggta aaccttatat ctatgatgag tcgaatgaaa atgatgaagg tttaaaaaga     3120

taccacaaag gacaatatga aattttaaag tttacagcga caaatgatga taaaaaaaat     3180

ataatagaga ttaagcctac ttatacatat tgtcaaaagc aattaaagcg aagttgtggt     3240

acgtttatta agcttactaa atttgctact gacgtattag gaaatatgta tgaagtaaaa     3300

gacaatgtct tgaaattaga atttgactag                                      3330


<210>  1555
<211>  3648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-218 DNA sequence

<400>  1555
atgagcaaaa aacgtatttt aggacttgac acaggcacaa acagtctagg ttgggcagtt       60

gttgaccagg aagaaaacgg tcagtacaca ttaattgaca aaggcgttgt aatcttccag      120

gaaggagtaa aaattgaaaa gggtgtcgaa tccagcaaag cagctgaaag aacggagcac      180

agagcacttc gcagacatta ttttcgcagg cgtttgcgca agatcgaggt attaagggtt      240

ttggtaaaat ataacctctg ccctaccata acggaagaag acctgaattt atggaagttg      300

cacaaaacat atcccaggaa ggacgaattc atggtgtggc agcacacaaa tgacaacgaa      360

gacatcaatc catatcattg tcggtacacc tgtctgaacg aaaatttaga cctggacagg      420

caacaggaca gatatatact ggggcgtgcc ttatatcaca tggcgcagcg cagaggtttc      480

ctgagcaacc gactggatgc aacggaagaa gatgaaaacg gagcagtaaa aagtagcatt      540

gccaacctaa acaaggaaat agaagagaac ggctgtaagt atttgggcga atacttctac      600

aaactatata aggagaaagg aaataccgta cgcatacgca cacgatatac cgacagagag      660

caacattata agaaagagtt tttcgccatt tgcgaaaagc agaacctacc aaaggaaatg      720

gtagaagctc tgacaagagc cctatacttc caacgtccct taaaaagtca gcggcagaac      780

gtaggaaaat gtacatttga aaaggggaag ccaagatgca gcgattcaca cccgacgtac      840

gaaatatacc gaatgctatc tttcctgaac aatgttaaga tacaagggcc ttgggatgaa      900

gaccttcgtc cgctcaacga agaagaattg aagcagatag acaagctatt ttacaggaag      960

agcaagccaa acttcgactt tgaagaaata gccaagaaga ttgcaggcaa aggcaaatac     1020

caatggaaag gagacaccaa gacggatttg ccatacaaat tcaactatcg aatgtcgcaa     1080

ggtgtgcccg gatgccccac aattgcacaa ctgaaggaaa tctttggcga gaattggaaa     1140

gagaacattg ccgaaaccta tacacttaac acaaaaaaag atggcacaca taagagtgcg     1200

gacgaaatgg ttgatgatat ctggaatgta ctcttcttct ttgacagcaa ggacaaggta     1260

aaggaatacg gcattaaaca tctacaattg gacgaggatc aggccgataa gttctcaaaa     1320

atacgcctca gccgtaatta cgcctctctc tcattgaagg caattaggta tatccttcca     1380

tttctacata aggggatgat atattccgat gcagttttct ttgccaaaat tcccgttatc     1440

attgggcaaa gcctatggca gaaacgccag cacgaaataa tggaggacct ctcctacgcc     1500

atacacatgg cgatgaaaga aaagcaacgc attgatgatg ctgtgaaaga ttacttacag     1560

aacaactttg atttgaaacc aggagcagca gatatgctct atcatccctc tatgatagaa     1620

acctatcccg atgcacaacc agacaaaaac ggagttgtat tactgggcag ccctcgcaca     1680

aacgccataa aaaacccaat ggcaatgcgc tctctgcatg aaatacgcaa ggttatcaac     1740

actctgataa aggaaggtaa ggttgcaccg gatacagaaa tacatatcga atatgcaagg     1800

gaactgaaca acgccaatat gcgagctgcg attcatgatt tgcaacgcga aaaagacaag     1860

aagcacaaag agtattcaga aaatatccgt aaactctaca aagaagcaac cggcaaggat     1920

atagaagcta ctgaaaccga catactcaaa ttccagcttt gggaagagca aggtcacatt     1980

tgcctataca caggagatga gattggcatt gcagatttca ttggagcaaa tcccagtttc     2040

gacatagagc atacaattcc ccgaagcgtt gggggtgaca gcacacaaat gaatatgacc     2100

ctttgcaata cccattacaa tagatttgta aagaaagcct atatacccac gcaattagcc     2160

gaccatgagt ttattatgac caggatagaa ccctggaagg aaaaaatcga agatctgaca     2220

aaacagatta accagattag gacaagcaat atttgggaca aagcagccaa ggatgcgaaa     2280

atcagaaaga agaaccgcct gttggaagaa ttaaagtact ggaaaggcaa atacgacagg     2340

tttactatga ccgaagtgcc agaaggcttt gcccgtcggc agggagcagg aattggtctt     2400

atctccaaat atgcagcatt gtacctaaag agctatttcc atgatacact tcatcctgag     2460

catagacagg tatatagcat caagggaacc ataacgtcag atttccgcaa gatgtggggc     2520

atacaggaag aggacgaaaa gaagtcaaga gacagccaca ctcaccattg tattgatgcc     2580

attgttattg cctgcatagg caagaacgaa ttcaacatga tgggacaata ttatcatgta     2640

caggagaaat tcgaaaaagg cgagggagaa aaacccgagt tcaagaagcc ttggccaaca     2700

ttcacccagg acctcaaaaa aattaaggag gaactggtgg tagttcacga cacacctgac     2760

aacatgccta aaaaagcaac caagacgatt gaaattagca agggccggaa agtcgtcgca     2820

aaaggagact gcgcacgcgg cagccttcac caagacacat attatggtgc aatagaaaga     2880

gacggaaaca taaagtatgt tgtacgcaaa ccgctgtcat cctttaccag cataaaggat     2940

ttagacaaca ttgtggacga tgcagttcgc caggcaattc tcaatgcgat agaaggcaag     3000

gacttcaaga aagcacttgc agaacccatc tatatgaaca aagataaagg cattttgata     3060

aagaaagtaa ggtgctatac accttctata acaaaacctt tacacatacg tacacatagg     3120

gacatatcac aaaaggaata caaacaacag ttccatgttg ctctggatag taactattgt     3180

atggctatct atgagggaga agtgaaagga aaaacaaaac gtacgtatga aataataaac     3240

atgcttgatg cagctgccta tttcaaaaaa agctcgaatc ttgccaaaca acatccaata     3300

gccccagaga acaaaaacga acttaaatat agatgttctg tacatactgg aacgcaagtc     3360

ctgcttttgc aatcggatgg cgaaaatata aatctcgaga acaaagacga tatagcaaga     3420

cgtctttacc atgttgctgt gatgcgaagt gatggacgta tagttcttcg ctacaatcaa     3480

gatgcaagag acgctacaac attgaagaaa gagcgtaaat ctggtgctta caaagtgggt     3540

gagcaataca gatccgaaat aatgttatct ctttctgact ttcatgctct agtagaagga     3600

tatgacttca caataacgcc tttaggtgag ataaaactaa aacattga                  3648


<210>  1556
<211>  4053
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-237 DNA sequence

<400>  1556
atgggaaatc agtcaggaca ggagtattat ctggggcttg atatcggaac agactctgcg       60

gggtgggcag taaccgatcc ggaataccgc attttaaggc ggaaaggaaa atcactgtgg      120

ggcgtgagac tgttcgagtc ggcaaatact gcggcagagc ggagagcatt tcgaacaaat      180

cgtcggagac ttcagagaag gcggcaacgg atccttcttt tgcaggaact gtttgcagaa      240

gaaatggaaa aagtggatgc aggttttttt cagagactga atgacagcgc ctgctgggca      300

gaagagaaag aggaaccgca gatttattct ctgtttggag gaaaagatta cacagatgtg      360

gattattaca gagaatatcc gacgatctat caccttcgca gtgcactgct ccggggaaaa      420

caggagtatg atctccggct tgtgtatctg gcgctgcatc atctgatgaa gcacagagga      480

catttcctgt ttcagggaaa tatcgaaagc gttacgtctt tccagacaac ttttcagaat      540

tttcaggact gtcttatgga tgaattcggt ctggagttgg aatgcgattc tgaggaaaga      600

ttttcagagc ttctgaaaga caggaaaatc ggcaggatgg aaaaatgccg gcagctggaa      660

cttctgtgtc atgtacagaa aacggataag cagaagaaag aaatctttaa actgattaca      720

ggtatgaagg ccggtttgtc tgtgatattt gcagatgagg aactggcaca gatcgactat      780

aataagatta gtttcgcaga atcaggttat gaggaggccc gtctggcgct ggaagaggag      840

atccaggaac ggacaggcat tctggatgtc tttcatgcgg tttatagctg ggcggttctg      900

gcagatattc tggcaggggg tgagtatgag ggaaggccct gtctgtgcgt ggcaaaagta      960

aatacatatg aaaagcaccg tcaggatctc cgtctgctga aaaaactggt gcgcgagtac     1020

tgcccggaag attacaaatc ttggttttcg gttcctgtga atgataacta ctgtgcttat     1080

atcggaacat ttcgcaaaaa cggaaaacgc tgtgagacaa agcgctgcaa tcaggaaaca     1140

ttttataagg cgttaaagaa gctgttggga aagatgtccg ctgatcttcc ggaagcggct     1200

gacattttaa aagagacaga aaatgggact tttttgccat tgcaggtcag taaagataat     1260

ggtgtgattc catatcaggt tcataaaatg gaattggagc ggatactcga tcatgcggag     1320

aaatatctgc cgtttcttct ggagaaagac ccggagtgtg ggaaaacagt cagggaaaag     1380

atcgttgccc tgtttgaatt ccggatcccc tattatgtag gaccgctgaa taccgccgcg     1440

ggagaaaact gctggatgga aagaaaagaa gaaggagcag tccgcccatg gaattttgat     1500

cagaaggtgg acagagacaa atctgcagag cggtttatcc ggagaatgac aaatcagtgt     1560

acctatctga ttcatgagac ggtattgccg aagcattccc tgctttattc ggaatttatg     1620

gttctgaatg aactgaacaa cgtaaagatt cgtgatgaaa agcttccggt ggaattaaaa     1680

cagggcattg tacagaagct gtttaagacc cggaaacagg tcacaggcag gaaactgctg     1740

gattacctga cggcaaatgg atacgatgtg aaaaaggatg aactgtccgg atttgatggg     1800

aattttaagg catctttgac ttcttatcat actttaaaaa agatatttgg taaagaactg     1860

gaaaaaagtt ccgtacagca gatggcagag gatatcatct tatggatcac attatatgga     1920

gaagatcaga agatgctttg cagagtaatc cggcagcatt atggtgagat actgaaagaa     1980

gaacagctga aagagctgtc cagattaaag tttcagggat ggggcaggtt atcccggaga     2040

tttttgaatg aactggaagg cgttgactgt acgaccggag agtgtatgac gatcatgcag     2100

ggacttagga acacacagaa taatctgatg cagcttttaa gtcagcagta tacgtttgcc     2160

cggatgatcg atgatgaaaa tggaggttat catgtggatg agattaccta tgataatctt     2220

gtaaaagata ttgtagcttc tccatccata aaacgtgctg tgtggcagac cattcagatt     2280

gtggaagaat tgaaaaatgt aatgggatgc gagccgaaaa aagtatttgt tgagatggca     2340

agaggggaag aagagaaaag gcgtacggtt tcccgtaaag acaaactgct ggaagcatat     2400

gcggcaatta aagatgaagc cagggactgg caggaggagt tacagaaata ttcagaagga     2460

gatctgaaag caatcaagct gtatctgtat tatacacaaa tgggccagtg catgtataca     2520

gggaagaaaa tagaactgtc ccagttaaac aacgcgacca tttgggacag ggaccatatt     2580

tatccgcagt caaagacgaa agatgacagt ctggataatc tggtgctggt ggacagaaga     2640

gtcaatgcaa agaaaagcga cgggatgata tctccggaga ttcagcagaa gatgcgggga     2700

acctggaaat atctgaaaga gaaaggattg atctcggaga aaaagtatga acgcctgacc     2760

cggacaacgc ctttgacgga agaagaactg gcaggcttca tcaatcgtca gctggtggaa     2820

accagacagt cttccaaagt ggtggcaacg ctgctgaaac gcatatatga agaagcagag     2880

attgtgtatg taaaggcgaa agcggtatcg gatttcagaa aagagcattt gaaatatgtg     2940

aaagtacgtg atctgaatga ctatcaccat gcgaaggatg cttaccagaa tatcgtagta     3000

gggaatgtct atcatacaaa gtttaccggt aatccgctgc gctggctgaa agaacatccg     3060

gagcggaaat acagtctgaa ccagatgttc aattatgatc tggaagtgca cggaaagcct     3120

gtgtggaaac gggggaagga tggaagcatt cgatgtgtga gtgagacact gaagcggaat     3180

gatattctgt ttacaaggta tgcgttctgc aataagggag ggctgtttaa tcagacgatt     3240

atgaaggcgc cggaagataa ggcaaaggcc aaaggacttg ttccgattaa gaagggaaag     3300

aatccggaaa aatatggcgg ttttacatcg gttacccctt ctcattttat gctggtggct     3360

tcggaaggga aaaaaggaaa ggagatccgg acaattgaga cggttccgct gtatcggaaa     3420

aaagaatttg agagagagcc ggagctgctg cttcagtatt gccgggaatt ttacgggtta     3480

aaaaatccga gaattctgat ttcctgtatt aagaaaaatg cacgtctggt tattaatggt     3540

tttccaatgc acctgaaagg aagcacagga aaacagctga tcttacaggg ggcggtacag     3600

ctgtgcctgg atgatgagaa agtggtgtac ttgaaaaaag tgactaacta tctggaagaa     3660

aatgccagaa gaaaggataa gcggacgctg ctggaagtga aggaaataac aggaattaca     3720

agtgaagcaa atataaattt atacgattta tttatcaaaa aactgagcag tacaatttat     3780

caatatcgac cggctaatcc aaaagataat cttctgaaag ggcgtgagaa gtttttaaat     3840

ctgggactgg ctgagcaatg tgtggttttg ggagagattt tgcatctgtt tcagtgtaaa     3900

ccacttagtg cgaacttgat attgataggt gcggctggca atacaggagt tacaaagatt     3960

gggaaggaaa ttagcaggtg caattcagca aagctggttt cccagtcagt gacaggtatt     4020

tatgagcagg ttgttgacct gctgaccata tga                                  4053


<210>  1557
<211>  3237
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-291 DNA sequence

<400>  1557
atgcaatggc cttatggagt cggactggat attggtgttg cttcgattgg atgggccact       60

gttgccctgg atgaaaaagc gcagccctgt ggcttgattc gtctggggag ccgtgtgttc      120

aagcgcgcag agcagccgaa gacaggagaa agtctggctg caccaagacg ggaggcccgc      180

ggcatgcgtc ggcgtttgcg ccgcagagct ttgcgcaaac aggatttcta tcagcttctg      240

gagaaaaatc atctgccgga caaggaagaa ctctcccggc tgtttgcggc aggtggtttg      300

gaggatattt acgcgctgcg caccagggcc ttggacgagg cggtgacacc gcaggaattt      360

gcgcgcattc tgctgcatct gatgcagcgg cgtggattca aaagcaaccg tctggcaggc      420

aagtcgaaaa aagacggagt gcttctccag gcggtaacac aaaatcaact gcgcatgcag      480

gaaaatggct ataggactgt tggcgagatg ctgtataaag acccgctttt tgcagcctgc      540

aagcgcaaca agggggaaaa ttatctttcc acagtcagtc gggaagaaat tgccaatgaa      600

gcgcagctgc tctttgaggc gcagcgcgaa aaaggccggg actgggcaac gccggaactg      660

gaagcggagt acctgtccat tcttttgcgt cagcgctcct ttgatcaggg ccccggcggg      720

aacagcccat acaagggcgg ctgggcggaa cgggttggcc cttgtacttt gctgccggaa      780

gaaaaacgtg cgttcaaaaa cacatacagc tttgagcgtt ttactttact gcaaaaaatc      840

aataatatcc ggatcgtgga atccggtcag acccaggcac tttcggatga agaacgtcag      900

aaagtaatgg acctggcgta tcgtgtggag actgtgccgt ataccctgat tcgcaaagaa      960

ctgcaatggc cgcagacaat ccggtttgcc gatgtgcggt atgatgtgga tgccgcaccg     1020

gaagcagcag aaaaaaagtg caaactcccg cccatgaaag gatatcatgc actgcgcaag     1080

gctctgggca cgcggcaggc agagcttccc ttgtgggatg atgtgattac cattctggca     1140

tctcaccggg atgaaggcgt ccggaaaaaa ctgctggaag aaaaaggtct gaccgcagaa     1200

caggtggaag ctgttctcgg cctggaattt tccggtgtgg ggcatatttc cctgaaggct     1260

tgtcagatgc tggagccgtg gctgctgcag gggctgaagt atgatcaggc atgcagcaag     1320

gccggattgg attttcgcgg tcatagcaat atcaaaaaaa cgcctaagct gccggcttca     1380

gctccggagc tgaaagacat caccagcccg gtggtgcgcc gtgcggtgtc gcagaccatc     1440

aaactggtca atgccatcat ccgcgaaatg gagcagccgc ctgtgtggat tcatattgaa     1500

ctggcccggg aactgagccg tacgtttgag gagcggcgca gggaccagaa atccatggaa     1560

gacaacgcca gacagaatga atgcctgatg caggagatcc gggatacctt ccacaaactg     1620

aaccctacgg gacaggattt gatcaagtac cgtctgtgga aagagcagga tgggatctgt     1680

gcttattctc agcaaagcat tgcggtggaa cggctgtttg aaaccggcta tgctgaggtg     1740

gatcatattg tgccgtacag catcagtttt gatgattccc gcagcaacaa agtgctggtg     1800

atggcggcgg aaaaccatca gaaggggaat cggctgccgc tgcaatatct tcagggagag     1860

cggcgcgaaa aatttattgt gtggacgaag tcgcaggtcc gcaactatcg caaacagaaa     1920

aatctgctgc gggaaacagt gagcgaagaa gaacaaaacg gtttcaagca gcgcaatctg     1980

caagacacac agtatatggc tcgctttttg ctgaattata ttcgggatca ccttgcattt     2040

gccgatcatc cggctgcggg caaacagcgg gtcatggcgc tggcaggtgc ggttaccagc     2100

catcttcgca aacgttgggg gctgacaaaa gtacgggcag acggtgacct tcatcacgca     2160

ctggatgcgg cagtcattgc ctgtgccacc aagggcatgg tacaacagat ctccggctat     2220

tatcaccgca ttgaaggtga gtatcagcag tcctctgatg ggacctattc cgtgcatacc     2280

cgtacaggcg aagtcttccc ggccccgtgg ccgcatttcc gggatgaact gatccagcgg     2340

ctgagccaga aaccacagga aaatctgatg cagtggaatc cggtgtttta ttccaatttt     2400

gatgtggaat cgatccggcc tgtttttgtg tcgcgtatgc cgcagcataa ggtgaccggg     2460

gcggcccaca aggaaaccat caaaagcccg aaagccctgc aggatggtct cctgatagtc     2520

aaacatcctc tgacggattt gaaattgaat aaaaagaccg gcgagatcga agggtactat     2580

cagccgtcca gcgacaagct gttgtatgag gcgcttcgcg cccggttgct ggaatttggc     2640

ggggatggca agaaagcctt cacagaaccg ttttacaagc caaaatcgga cggcacgccg     2700

gggccgctgg tgcgcaaggt caagctgtgc gaaaaggcca gtctgtgtgt tccggttcat     2760

ggcggaaatg gtgcggccga taacgacagc atggtgcgcg tggatgtgtt ctttgtcccg     2820

ggggacgggt attacatggt tcccatttac gtttccgaca ccaaaaagaa agaactgccc     2880

aacagggctg tggtggcaca taaggagttc tctgcatgga aggtgatgga ggaaaagaac     2940

ttcctgttct cgctgtatgc ggatgactta attgaggtgg ctcgtaaaaa agtaatgcca     3000

tttactatag tcaatagtgg gagcacttta cccccctcct atgaaacaac tcatgagatg     3060

gtgtattacg gagggttaga tatttcttct ggtaatataa aagttacaat ccatgataat     3120

tcgtactctc ttagaggact cggaattaag acgttaaata cccttcaaaa atatgaagta     3180

gatatcctag gcaatgtgag agaggtgaaa aaagaaaaac gtcaatcttt tcgataa        3237


<210>  1558
<211>  3294
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-308 DNA sequence

<400>  1558
atggcttacg caattggttt agacataggt attgcttctg tgggttatgc agtagttgca       60

cttgattatg aagaaaatcc atggggtatc atcaatatgg gttctaggat ttttgatgct      120

gctgaaaatc ctaaagatgg ggcttcgtta gctgctccta gacgtgaggc acgtactggt      180

agaagacgtt tgcgtagaag aaaacatcgt attgaacgca ttaaaaattt gtttttaaat      240

actcaactgc tgacaaaaga acaattagag aagttgtatg aaggtgtttt atctgatgtt      300

tatgaattaa gggttaaagg tttagatgaa aagctgacgg ctgaagaagt tgcccgagtt      360

ttattacatt tggcacatcg tagaggcttt aagtctaatc gtaaagcaga aaaaactgat      420

aaagaaaatg gtgcattgct tactgccgtt agtgaaaacc aaaaacgtat gaaagataag      480

caatatagaa ctattggtga gatgttccat aaagacgagc tttttgcaga atacaaacgt      540

aataaaggtg gtacatactt aacaacagtt gctagagaaa tgattgcgga tgaagcaaaa      600

tatattattg ctacacagag aagctttggt aataaaacat tgacaataga gtttgaagaa      660

agttatttag atatactttt aagtcaacgt aattttgatg aaggacctgg tgggaatagt      720

ccgtatggcg gtgaccaaat tgaaagaatg ataggaaact gcacatttga gaaaagtgag      780

aagcgctgtg caaaatcttg ttattctttt gaatacttta atttgttgca aaaaataaat      840

catttacgat tgttagtaga tggtgtgaag gttgaacttg atggttctca aaaatctaaa      900

gttataaatc ttgcaaaaac gaaggcagat ttaaaatata gccaaatcag gaaggaattg      960

ggattaggtt cgcaagttct attcaatgct ctagtttata attctgatgt agaagaagta     1020

gagaaaaaat caaaatttaa ttttatgcct gcgtatcatc aaatacgtaa agaattagat     1080

acagttgtca agggaagaat agaagctata gacatagata ctcttgatga aataggaaga     1140

attttatcaa catataagag tgatgctaaa cgtatagaag catttagtaa tttgaatata     1200

acttcaaaag atatggaagc attgcttaat attaatggtt taagaaaatt tggtcactta     1260

tcattaaaag cgttaaagaa gattacacct tttttggaac aaggaatgat ttataacgaa     1320

gcttgtactg ctgcgggtta tgagttccgt gggcatagtg gttatgaaaa aactttctta     1380

ctaccgtcac aaacagaaga aatggaaaat gttactagcc ctgtggcaag acgttctatt     1440

tcacaatcca ttaaagttat taatgccatt attcgagaac aaggagaaag tcctttatac     1500

ataaacgtgg aacttgcaag ggaaatggca aaagattttg atgaacgcaa aaaaataaaa     1560

aaggaaactg acgaaaacca agcaagaaac gaaaggctga tagaaaaaat tagaaatgaa     1620

tttcataagc agaatcctac agggttggat ttagtgaaat tgaaattatg ggaagaacaa     1680

gatggtgtta gtccttactc acaaaaacaa atagttattg aaaggttgtt tgaaccaggg     1740

tatgtagatg tagaccatat tgttccctac agtatcagct ttgatgatac tatgaaaaat     1800

aaagtattag tttttgcttc tgaaaataga gaaaagggta aaaacctgcc agtagaatac     1860

cttgcacgta aaaaaggaca aaaggctgtt gatgacttta aggtatgggt tactagtaat     1920

gttagaaatt acaaaaaacg acttaacttg ttaaagtcag aagttacgga agaagactta     1980

aataaattta aagagcggaa cttgcaggat acaaaaacaa tttctcgttt tatgtataac     2040

tatatcagtg accatcttat ttttgcaccg tctgaaactg gtaagaaaaa gcgtgttact     2100

gctgtcaatg gggcgataac ttcctatttg cgtaaacgtt ggggtataaa taaagtgcgt     2160

gctgatggag ataagcatca cgctgttgat gctttggtaa tagcttgcac cacagataaa     2220

ctgattaaag accttagtta tcactcaaga tatctcgaaa tggaatacga agctggcgaa     2280

aaagaaagtt tgtgggtaaa tcgtaatact ggcgaaatag ttaaacgttt tccttatccg     2340

tgggaagatt ttagagcaga actaatggca cgtttatcag atgctcctga agttgcttta     2400

agaaaattgc aattgttata ttaccaagat aaggatttaa gtaagattaa acctattttt     2460

gtgtctcgta tgccacggcg taagattact ggagcagcac ataaagctac agttcgtggg     2520

gcacgttacg ttgataaggg gattgtaatt tccaagaaat ctttgagtga gcttaaactt     2580

aataagggtg gtgagattga aaactatttt gctcctgaaa gtgatagact actgtatgag     2640

gctttgaagg aacaacttaa aaagtttaat ggcaatgcaa aaaaagcttt tgagcaaggg     2700

ttttataaac ctaaagcaga tggtacgcct ggtccaaaag ttaataaagt aaaggtttat     2760

gataagtcta ctttaaatgt tgccgtgcaa caaggaactg gtgccgctga taatgatagt     2820

atggtaagag ttgacgttta taaggtagaa ggagatggtt attaccttgt tcctatttac     2880

gtggcagata ctttaaaaaa agagttacct aataaagcaa tagtacaagg gaaaacttat     2940

gagcaatgga aagaaatgtc accagaagat tttgttttct ctttgtatcc caacgatttg     3000

ataaagatta ctcacaaaaa ggagataaac tttagtagag ttagcgaaga tagtacatta     3060

gctgattctt acaaaacaaa agaagagttc gtttattata aaaagactag tatttcaaca     3120

gctagtataa gcataataaa caatgataat acatatacta ttcctagttt gggtgtaaaa     3180

acattagctt ctctagaaaa atatcaagtt gatattttgg gtaactatac caaggtagga     3240

aaagaaaagc tacaaacatt tgctgcttat caacaagcta aaaagaagcc ttga           3294


<210>  1559
<211>  4044
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-103 Codon optimized for human cells

<400>  1559
tctatcaaga gcgactactt cctgggcctc gacatcggca cagattctat cggatgggcc       60

gtgacagacc ccgagtacca catcctgaga agaaagggca aagccctgtg gggcatcaga      120

ctgttcgatg ccgccaatac tgccgccgag agaagaacct tccggaccag cagaagaaga      180

atccagcggc ggagacagcg gatcagactg ctgcaagagc tgttcgccga ggaaatggtt      240

aagctggacc ccggcttctt ccagagactg agcgatagcg ccttctggca agaggacaag      300

caagagcagc agatctacag cctgtttacc tgcgagaact acaccgacgt ggactactac      360

agagagtacc ccaccatcta ccacctgaga agcgccctga tccaagagaa aaaagagttc      420

gacctgcggc tgctgtatct ggccctgcac catctgatga agcaccgggg ccactttctg      480

ttcaacggca gcatcaacaa cgtgaccagc ttccacacca ccttccagac cttcgccgac      540

tgcctgtacg acgagttcga catcgagctg gaatgcgaca gcgaggacag attcgccgag      600

atcctgaagg ataagcacgc cagaaagacc ggcaagtgct ctgagctgga aatcatctgc      660

cacatcgaga agtccaacaa gcagctgaaa gaactgttca agctgatcac cggcatgaag      720

gccagcctga gcgtggtgtt tggagatgat gagctggccg agatcgagca caacaagatc      780

agcttcagcg agagcagcta cgacgaagtg cggctggccc tggaagatga gattcaagag      840

agaaccggca tcctggacat cttccacgcc gtgtattctt gggccatcct ggccgatatt      900

ctggaaggcg gcgagtacga gggcaacagc tatctgtctg tggccaaggt gtccacctac      960

aagaagcacg gcgacgacct gagactgctg agaacactcg tgcgcgagta ctgccccgac     1020

cactacaaga gctttttcag cgtgtccggc aaagagaact actgcgccta cgccggcaca     1080

ctgaagaaga acggcaagaa gcagcccatc aagcggtgca gccaagagga cttctacaag     1140

gccctgaaga aactgctgaa ccagatgcct accgagcagc ccgaagtgaa ggatatcttc     1200

atcgagattg agaacggcac cttcctgcct ctgcaagtgt ccaaggacaa cggcgtgatc     1260

ccctaccaag tgaacaagat ggaactcgag aagatcctgc agaacgccga agagtacctg     1320

cctttcctga agaacatcga cgaggaatgc ggcaagaccg tgtccaagaa gatcatcgac     1380

ctgttcgagt tcagaatccc ctactacgtg ggccctctga ataccgccaa gggcgagaat     1440

tgctggatgg ttcgaaaaga ggccggcaga atctacccct ggaacttcga tgagaaggtg     1500

gacagagatc agagcgccga gaagttcatc agacggatga ccaaccagtg cacctacctg     1560

atccacgagg acgtggtgcc taagaacagc ctgctgtact ccgagttcat ggtgctgaac     1620

gagctgaaca atgtgaagat tcggagcgag aagctgcccg tggaactgaa gcaggccatc     1680

gtgctggacc tgtttaagaa gcagaagcag atcacaggga agaagctgct caactacctg     1740

aacgccaacg gctacgacgt gaagaaagag gacctgagcg gcttcgacgg caacttcaag     1800

tccagcctgt ccagctacct gactctgaag aaggtgttcg gagaggaact ggacaagtac     1860

agcgtgcagc agatggccga ggacatcatc ctgtggatca ccctgtatgg cgacgatcag     1920

aaaatgctgc ggagagtgat ccggaagcac tacgagcagc agctgtctga ggaacagatc     1980

ctgagcctga gcaagctgaa gttccaaggc tggggcagac tgtctagacg gctgctctct     2040

gaaatggaag gcgtggactg tgaaaccggc gagtgcatga cagtgatgca gggcctgaga     2100

aacacccaga acaacctgat gcagctgctg agccagcagt tcagcttcat ggaactgatc     2160

gaggaagaga acgggaacta ctacgtcgac gagatcacct acgacaacct ggtcaaggac     2220

atggtcatca gccctagcgt gaaaagggcc gtgtggcaga cagtgcagat cgtggaagaa     2280

atcaagggcg tgatgggatg ccagcctaag aaaatcttcg tggaaatggc ccgcagcgac     2340

gaagagaaga aacggaccgt gtctcggaag gatcggctgc tggaagccta cgacgccatc     2400

aaggatgagg cccggcaatg gcaagaagaa ctgcagaaat actccgacgg cgatttcaag     2460

gccatcaagc tgtacctgta ctacacccag atgggccagt gcatgtacac cggcagaaaa     2520

atcgatctgt cccagctgaa cgacgccacc gtgtgggata gagatcacat ctaccctcag     2580

agcaagacca aggacgacag cctggacaat ctggtgctgg tggatagatc cgtgaatgcc     2640

aagaaaagcg acggcatgct gagccccgag atccagcaga gaatgagagc cacctggaag     2700

tacctgaaag aaaagaagct catcagcgag aagaagtacg agcggctgac cagagtgtcc     2760

cctctgacag atgaagaact ggccggcttc atcaaccggc agctggtgga aacaagacag     2820

agcagcaaag ccgtggccac actgctgaag agggtgtacg atgaggccga gattgtgtat     2880

gtgaaggccg aggccgtgtc taacttccgg cgggataacc tggactacat caaagtgcgg     2940

gacctgaacg actaccacca cgccaaggac gcctaccaga acatcgtcgt gggcaacgtg     3000

ttccacgaga agtttaccag caatcccctg cggtggctga aaaacaaccc caacaccaag     3060

tactccctca accagatgtt caacttcgac ctggaaaaga acggcgtggt catctggaag     3120

agaggcaagg ccggctccat taagtgtgtg gaagagacac tgaagcggaa cgacatcctg     3180

ttcaccagat acgctttctg caacaaaggc ggcttcttta atcagatgct gaccgccgct     3240

ccagaggata agacaaaggc caaaggcctg gtgcctatca agaaaggcat ggaaacctgg     3300

aaatacggcg gctacaccag cgtgacccct agccacttta tgctggtggc cagcaaggac     3360

aagaagggaa aagagatccg gaccatcgag acagtgcccc tgtaccggtg gaaagagttc     3420

aaagagaatc ccgacgctct gctccagtac tgcagagagt tctacggcct gaaagagccc     3480

aaggttctga tcccttgcat caagaagaat gcccggctgg tcgtgaacgg cttccctatg     3540

cacctgaagg gcagcaccgg aaaacagctg attctgcagg gtgccgtgca gctgtgcctg     3600

aacaacgaga acatcaagta cctcaagaaa gtgacgaagt acctcgagta caacgcccag     3660

cggagagaca agagaaccct gctcgaagtt cgggaagtga ccggaatcaa caaagaggaa     3720

aacatccagc tgtacgatgt gttcgtggac aagctgagca acacaatcta ccagtacaga     3780

cccgccaatc ctaaggacaa cctcatcaag ggccgcgaga aattcatcga gcttggcctg     3840

gctgagcagt gcgtggtgct gggagaagtg ctgcatctgt tccagtgcaa gcccctgacc     3900

agcgatctga cactgatcgg cggaagccct aacaccggca ccatcaagat caccaagacc     3960

atcagcaact gcaacgtggt caagctgctg tcccagtcta tcgccggcgt gaaagtccgc     4020

gagatcaacc tgctgatcat ctga                                            4044


<210>  1560
<211>  3288
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-124 Codon optimized for human cells

<400>  1560
ggcaagatca tcggcctgga catcggaatc gcctctgttg gatgggccgt gctggacaag       60

gacagctaca agatcgtgga agccggcagc aatatctttc ctgccgccga ggccagcaag      120

aatcaagaga gaagagagtt cagaggcctg cggcggatga ccagaagaag aaggaccaga      180

ctggacgact tcaagaagct gtggaagaac tactacaaga acgagtacag cgtgacccct      240

aacaacgtga ccgagctgaa agtgaagggc ctgagcgagc agctgtccga gctggaactg      300

tacaccgtgc tgtactccta cctgaagcac cggggcatca gctacctgga agatgccgtg      360

gatgagggca agaccggcag cgattatctg aagggactgc agaccaacca gaaagagatg      420

aacaccaagt ttcccagcca gatccagtac gagcggctcg agaagtacgg ctgcttcaga      480

ggcgagaaca aggtgtccga tgacgaggtg ctgagcaacg tgttcaccac cagcgcctac      540

aagaaagaaa tcgaggaact gatcagcgtg caggacaacc tgggcaacga gctggataag      600

gacttcatca agaagtactt tgagatcttc agccggaagc ggaagtacta cgaaggccct      660

ggcaatgagc tgagcagaac cgactacggc atctacacca ccaagatcga cgagaacggc      720

aactacatca ccgacaagaa cctgttcgag aagctgatcg gcaagtgcag cgtgtacccc      780

gaggaaatga gagccagcgc cgcctcttac acagcccaag agttcaacgc cctgaacgac      840

ctgaacaatc tgatcgtgaa cggccggaag ctgaccaaag aggaaaagat cagcatcatc      900

gagtgctaca agaccgagaa aaccatcaac gtgcggaaga tcattaagaa cgtgatcggg      960

gagaacatcg accagctgag cggctaccgg atggacaaga atgacaaaga gctgtaccac     1020

accttcgagg tgtacaacaa gctgagaaag gccttcgaag aggccggcat ctccttcgac     1080

ttcagcagag aggactttga cgagatcggc agaatcctga cactgaacat cgagagagag     1140

ggcatcgagg acgccatcag aatcagcaat ctggtgctgt cctctgacgc cgtggacgtg     1200

ctgatctccg tgcggaaaaa gaacgccagc ctgttcagca agtggcacag cttcagcctg     1260

aagatcatga acgagctgat ccccgagatg tacgagcagc ctaagaacca gatggaactg     1320

ctgagcgaca tgaagtccat caagagcaag atggatgagt tcaagggcct cgaggatatc     1380

cccgtggaaa ccatcattga ggacatctac aaccccgtgg tcaagcggag catccggatc     1440

accatcaaga ttatcaatgc cctcaagaag aagtatagcg acatcgagaa gatcgtgatc     1500

gagatgccca gagacaagaa cagcgacgag gaaaaagagc ggattaagaa gttccagaaa     1560

gaccaagaga atgagctgcc caacatcatc aagcgcgtga aggacgagta cggcatcacc     1620

ctgacacctg agctgatcgc cagaaagaaa ggactggcct ttaagctgaa actgtggaac     1680

gagcagaacg gcagatgccc ctacagcggc agaatgatcg acattgagag cctgatcaac     1740

gacggcgatc tgttcgaggt ggaccacatc atccctctga gcatcagctt cgacgacagc     1800

cggtctaaca agaccctggt gtacagagtg gaaaatcaag aaaagaagaa caacacgccc     1860

ttcatgtacc tgagccggct gaacagacag tggaactacg acaagttcgc cgccttcatc     1920

aaagaactgt acggcagcag cggcaaggac cggaagaaat tccggaagaa gatgaacaac     1980

ttcctgttca ccgaggacat taacaagatc gatgtgctga agggctttat caaccggaac     2040

atcaacgaca ccagatacgc cagcagagtg gtgctgaata gcctgcaggg ctacttccgg     2100

gccaacgaca acaatgtgaa agtgtccgtg atcaacggca gcttcaccca ccagatgaga     2160

gtgaacctga gcctgggcaa agacagggat gagtcttttg cccaccacgc tgtggacgcc     2220

atgctgattg ctctgagcca gatgggctac gacgccttca gagccagaca gaaagacatc     2280

gtggacttcg agacaggcga gatcatcaat ggcagcgcct gggagaacca ggatgagatg     2340

tacaagacag tgctgtatca agagaagtgg aagaatatca aggacaatat catcgaagcc     2400

gagccgaaca tcaagtactg gcacaaggtg gacaaaaagt gcaaccgggg cctgtgcaac     2460

cagaccatct acagcacacg gaagtgcgac gataagatct ggaaagtgga caagctgaac     2520

atccgcgaca aggacgacgt gaagaaactg atctacatga tccagaacgg aaaagaggac     2580

aaaatcctga tggcccagaa cgaccccaag accttcgcca acctgaagta catcctggat     2640

gagtactccg actgcgagaa ccccttcgtg tcttacgaga aagaaaccgg cgacctcgtc     2700

cggaagtaca gcaagaagca caacggcccc aagatcacct acctcaagta catggtggaa     2760

gaagtcaaca gctgcatcga catcagccac aaatacggcc acgagaaggg cagcaagaaa     2820

gtgtttctgg cccagctggt gcccttccgg accgacgtgt actacaacaa caactccggc     2880

aagtactacc tgatcggaat caagcagtcc gacatcaagt gcaagggcaa ccagtacatc     2940

atcgacgaag agaagtacac cgacaacctg attcagaacg gcctgctgaa agagggccag     3000

aagatcgagg acctggaaaa gctgggctac ctgttcaagt tcagcatctt caagaacgat     3060

accatcgagt ttgagaagaa gggcgagctg attaagtgcc ggttcctgtc tcagaactcc     3120

gcctccaaga accggatcga agtgaagccc atcggcaaga aggactacga gagccggaat     3180

ctgcctacac tgagcaccac cacagtgatc aacaaatacg tcaaggacat cctcgggaac     3240

gaaaaacagg tgtccggcga gaagttcgag atcattgtgg acagcaag                  3288


<210>  1561
<211>  3324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-127 Codon optimized for human cells

<400>  1561
ggaaagctgg tgctgggcct cgatatcggc atcacatctg tcggctacgg cgtgatcgac       60

atcgacaaca acaagttcgt ggattacggc gtgcggctgt tcaaagaggg cgacagcaac      120

gacaacgaga agcggagaag ctacagaagc ggcagacggc tgcggcggag aaagaagaac      180

agactggacg acatgaagtc cctgctgctg tctgccggca tcctgaccaa ggactacaag      240

cccctgaaca acatctacga gatcagagtg aagggcctga ccgagaagct gaccaacaat      300

gaactggccg ctgctctgct gcacatcacc aagaatagag gcaccaccgt ggaagccctg      360

gaaaccgccg atgctgacaa agaagccgcc ggaacaaagg acgtgctggc caagaatgcc      420

aaggacctgg aacagttcga gtacgtgtgc aaggtgcagc tgtaccggct cgagaagtac      480

ggcaatatcc ggggcaccga gaacaacttc aacaccagcg actacgtgaa agaggccaga      540

gccatcctga agtgccagga catcgacgtg gaactgagcg agagcatcgt gaacatcatc      600

agccggcgga gagagtacta cgaaggccct ggaagcgaga agtcccctac caaatacggc      660

agatggatcg agaagggcgc cgagcctatc gacctgattg agaagatgcg gggcaagtgc      720

agcatctacc acgatgagct gagagcccct aagagcagct acagcgccga gctgttcaac      780

ctgctgaacg acctgaacaa tctgagcatc aacggcgaga aactgaccca gaacgagaaa      840

gagatcgtca tcgaggaagt gaacaacaac ggcaagatca ccatcgacaa gctgaagaag      900

ctgctgaaca tcaacgacag caaggacgtg gtggaaggct tccggatcaa caagagcaac      960

gagctgctgc tgaccaatat ggctatgtac gaccagttca agaagatctt tgacaagcac     1020

aaagaggacg cctaccagcg ggacaagtac atcatcgacc agatcgccga gatcaacacc     1080

gccaagaagg gcatcaaaga gagatgcgac gccatcgaga agcagttccc caacttcgac     1140

tacaacctga tccgcgacct ggccgagatg aagaagatga cccagtacca cagcctgagc     1200

ctgaaggcca tccgggaaat caacaaagag atgatcaaga gcccgtacaa ccagatgcag     1260

gccatccatg aactgggcct gcagcactac agaaagtcct acaagggcat gaagaaaatc     1320

caggtggacg aggaagccat tctgagccct gtggtcaaga gagcccagcg ggaaaccttc     1380

aaagtgatca acagactgag agagatctac ggcgagttcg agagcattgt ggtggaaacc     1440

accagggaca agaactccaa agagaagaaa gagcggatta acaagaccca gaagtattac     1500

gaggaccgga acaagaaagt ggacgaactg ctgaaagaga gaggctacaa ccccgacacc     1560

attaacaaca agaccaagat gaaggtcaaa ctgtacctgg accagaacgg caagtccgcc     1620

tacaccatga cacccctgaa gctgaacctg atcatcacca atcctcacgc ctatgagatc     1680

gaccacatca tccctctgtc catcagccag gacgacagct tcaacaacaa agtgctgatc     1740

acccacgaag agaatcaagt caagggcaac aagacaccca tctacaccta cctcaacaac     1800

cagtttaaga actgcgatat caacaagtac aaagaaagcg tgaagaacaa ccacaacttc     1860

agccggaaga aaaagttcta catgctgtac gagaaggaca tcacgaagta cagcaacatg     1920

aaggagttta tcgcccggaa cctggtggac accagctacg cttctagagt ggtgctgaac     1980

accctgacca gctacttccg ggacaacgac atcagcacca acgtgcacac aatcagaggc     2040

agcgccacca gcctgtacag aaagagaatc ggcctgaaga aggaccgcga caaggatttc     2100

ctgcaccacg ccattgatgc actgatcgtg gccagcatca agaagcagag catctttcgg     2160

aagtacctga tcaagtacaa cctcagcgag ctgtacaacg aaaagaccgg cgagctgatc     2220

aaggtggaag aggactctaa agtgatcgac cccgtgttca tcgagttcat cagcaacctc     2280

aagacaatct acgagcagag ctaccagtac tacaacggct acatctctcg gaacaaaatg     2340

aagttcaagc ccatcaagat cagccacaag gtggacacaa agcccaaccg gaagatcagc     2400

gacgaaacca tctacagcac ccggaacgtg aacggcgtgg aacgggtcgt gaagaaagtg     2460

aaggatatct acgaccccaa gttcgacaaa ctgaccaacg atatcatcaa caatcagtat     2520

cacaacaagt ggatcatggc cgagaaggat gagcagacct tcgagatcat caagtccatc     2580

gtgatggccc acttcaatac ctacaaagaa gataaggaca tctacaagtc caagagcaag     2640

aaaggcgtga ccacatggtc cctgaagggc agcaacaacc ctctgagcca gtttaaagag     2700

gaacacggga agatccgcaa gtactctaag aaaggcaacg gccccgagat caccagcatg     2760

aagtactatg aggacgagct gggcaaccac gtgaacatta ccaaaaagta caacgtggac     2820

aacaagaacg tggtcctgct gcagatcagc ccctacagaa ccgacttcta cgtgtcccct     2880

aagggcaagt acaagtttgt gaccatccgg tactgcaacg tgttctacaa agagagcaac     2940

aagaagtatc tgatcgataa gaagtggtac gaagaggaaa agaaaaagaa gaagatcgac     3000

gactcctacc agttcgtgtg ctccctgcac catgatgaga tcctgggcgt gaagctggaa     3060

gatggcaagc cctacatcta tgacgagtcc aacgagaacg acgagggcct gaaaagatac     3120

cacaagggcc agtacgagat tctgaagttc accgccacca acgacgacaa gaagaatatc     3180

atcgagatca agcccacgta cacctactgc cagaagcagc tgaagagaag ctgcggcacc     3240

ttcatcaagc tgactaagtt cgccaccgat gtgctgggca atatgtacga agtgaaagac     3300

aacgtgctga agctcgagtt cgac                                            3324


<210>  1562
<211>  3654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-218 Codon optimized for human cells

<400>  1562
ggtaccagca agaagagaat cctgggcctc gacaccggca caaattctct tggatgggcc       60

gtcgtggacc aagaggaaaa tggccagtac accctgatcg acaagggcgt cgtgatcttc      120

caagagggcg tgaagatcga gaaaggcgtg gaatctagca aggccgccga gagaacagaa      180

cacagagccc tgcggagaca ctacttccgg cggagactga gaaagatcga ggtgctgaga      240

gtgctggtca agtacaatct gtgccccacc atcaccgaag aggacctgaa tctgtggaag      300

ctgcacaaga cataccccag aaaggacgag ttcatggtct ggcagcacac caacgacaac      360

gaggacatca acccctacca ctgccggtac acctgtctga acgagaacct ggacctggac      420

agacagcagg accggtatat tctggggaga gccctgtatc acatggccca gagaagaggc      480

ttcctgagca acagactgga cgccaccgaa gaagatgaga acggggccgt gaagtcctct      540

atcgccaacc tgaacaaaga gatcgaggaa aacggctgca agtacctggg cgagtacttc      600

tacaagctgt acaaagaaaa gggcaacacc gtgcggatca gaaccagata caccgacaga      660

gagcagcact acaagaaaga gttcttcgcc atctgcgaga agcagaacct gcctaaagaa      720

atggtggaag ccctgacacg ggccctgtac ttccagaggc cactgaagtc ccagagacag      780

aacgtgggca agtgcacctt cgagaagggc aagcccagat gcagcgactc tcaccccacc      840

tacgagatct accggatgct gtccttcctg aacaacgtga agattcaagg cccctgggac      900

gaagatctgc ggcccctgaa tgaggaagaa ctgaagcaga tcgataagct gttctaccgc      960

aagagcaagc ccaacttcga cttcgaggaa atcgccaaga agatcgccgg caagggcaag     1020

taccagtgga agggcgatac caagaccgac ctgccttaca agttcaacta cagaatgagc     1080

cagggcgtgc ccggctgtcc tacaattgcc cagctgaaag agatctttgg cgagaactgg     1140

aaagagaata tcgccgagac atacaccctc aacaccaaga aggacggcac ccacaagagc     1200

gccgacgaga tggtggacga catctggaac gtgctgttct tcttcgacag caaggacaaa     1260

gtgaaagagt acggcatcaa gcaccttcag ctggacgagg accaggccga caagttcagc     1320

aagatccggc tgagcagaaa ctacgccagc ctgtctctga aggccatccg gtacatcctg     1380

ccttttctgc acaagggcat gatctacagc gacgccgtgt tcttcgctaa gatccccgtg     1440

atcatcggcc agagcctgtg gcagaaacgg cagcacgaga tcatggaaga tctgtcctac     1500

gccatccata tggccatgaa ggaaaagcag cggatcgacg atgccgtgaa ggactacctg     1560

cagaacaact tcgatctgaa gcctggcgcc gctgacatgc tgtatcaccc cagcatgatc     1620

gagacttacc ccgacgctca gcccgacaaa aatggcgttg tgctgctggg cagccccagg     1680

accaatgcca ttaagaaccc catggctatg cggagcctgc acgagattcg gaaagtgatc     1740

aacaccctca tcaaagaggg caaagtcgcc cctgacaccg agatccacat cgagtatgcc     1800

cgcgagctga acaatgccaa catgagagcc gccatccacg acctgcagcg cgagaaggat     1860

aagaagcaca aagagtacag cgagaacatc cggaaactct acaaagaggc caccggcaag     1920

gacatcgagg ccacagaaac cgacatcctg aagttccagc tgtgggaaga acagggacac     1980

atctgcctgt acaccggcga cgagatcgga atcgccgact ttatcggcgc caatcctagc     2040

ttcgacatcg agcacacaat ccccagaagc gtcggcggcg atagcaccca gatgaacatg     2100

accctgtgca acacccacta caaccgcttc gtgaagaagg cctacattcc cacacagctg     2160

gccgaccacg agtttatcat gacccggatc gagccctgga aagaaaagat tgaggatctg     2220

accaagcaga tcaaccagat ccggaccagc aacatctggg acaaagccgc caaggacgcc     2280

aagatcagaa agaagaaccg gctgctcgag gaactgaagt actggaaggg gaagtacgac     2340

cggttcacca tgacagaggt gcccgaggga tttgccagaa ggcaaggcgc cggaatcggc     2400

ctgatttcta agtacgccgc tctgtacctg aagtcctact tccacgacac actgcacccc     2460

gagcaccgcc aggtgtactc tatcaagggc accatcacaa gcgatttccg gaagatgtgg     2520

ggcatccaag aagaggacga gaagaagtcc agggacagcc acacacacca ctgcatcgac     2580

gccatcgtga tcgcctgcat cggcaagaac gagttcaaca tgatgggcca gtactaccac     2640

gtgcaagaga agttcgaaaa aggcgagggc gagaagcccg agttcaagaa gccttggcct     2700

accttcacac aggatctgaa gaagatcaaa gaggaactcg tcgtcgtcca cgacacccct     2760

gacaacatgc ctaagaaggc caccaagacc atcgagatca gcaagggcag aaaggtggtg     2820

gccaagggcg attgtgccag aggatctctg caccaggata cctactacgg cgccatcgag     2880

cgcgacggca acatcaaata tgtcgtgcgg aagcccctga gcagcttcac cagcatcaag     2940

gacctggata acatcgtgga tgatgccgtg cggcaggcca tcctgaatgc catcgaggga     3000

aaagacttca agaaggccct ggctgagccc atctacatga acaaggataa gggcatcctg     3060

atcaagaaag tgcggtgcta cacccctagc atcaccaagc ctctgcacat cagaacccac     3120

cgggacatca gccagaaaga gtataagcag cagttccacg tggccctgga cagcaactac     3180

tgcatggcca tctacgaggg cgaagtgaaa ggcaagacca agcggaccta tgagatcatc     3240

aacatgctgg acgccgctgc ctacttcaaa aagagcagca acctggccaa gcagcaccct     3300

atcgctcccg agaacaagaa tgagctgaag taccggtgca gcgtgcacac aggcacacaa     3360

gttctgctgc tgcagagcga cggcgagaat atcaacctgg aaaacaagga cgatatcgcc     3420

agacggctgt accatgtggc cgtgatgaga tccgatggca gaatcgtgct gcggtacaac     3480

caggacgcta gagatgccac cacactgaag aaagagcgca agagcggcgc ctacaaagtg     3540

ggcgagcagt acagatccga gattatgctg agcctgagcg acttccacgc tctggtggaa     3600

ggctacgact tcacaatcac ccctctgggc gagatcaagc tgaagcacgg atcc           3654


<210>  1563
<211>  4059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-237 Codon optimized for human cells

<400>  1563
ggtaccggca atcagagcgg ccaagagtac tacctgggcc tcgatatcgg cacagattct       60

gccggatggg ccgtgaccga tcctgagtac agaatcctgc ggagaaaggg caagagcctg      120

tggggcgtca gactgtttga gtctgccaac acagccgccg agcggagagc cttcagaaca      180

aacagaagaa ggctgcagcg gcggagacag cggattctgc tgctgcaaga gctgttcgcc      240

gaagagatgg aaaaggtgga cgccggcttc ttccagagac tgaatgatag cgcctgctgg      300

gccgaagaaa aagaggaacc ccagatctac agcctgttcg gcggcaagga ctacaccgac      360

gtggactact acagagagta ccccaccatc taccacctga gatctgccct gctgcggggc      420

aagcaagagt acgatctgag actggtgtat ctggccctgc accacctgat gaagcaccgg      480

ggacattttc tgttccaagg caacatcgag agcgtgacca gcttccagac cacctttcag      540

aacttccagg actgcctgat ggacgagttc ggcctggaac tggaatgcga cagcgaggaa      600

agattctccg agctgctgaa ggaccggaag atcggcagaa tggaaaagtg ccggcagctg      660

gaactgctgt gccacgtgca gaaaaccgac aagcagaaga aagagatctt caagctgatc      720

accggcatga aggccggact gagcgtgatc tttgccgatg aggaactggc ccagatcgac      780

tacaacaaga tcagcttcgc cgagagcggc tacgaagaag ccagactggc cctggaagag      840

gaaatccaag agagaaccgg catcctggac gtgttccacg ccgtgtattc ttgggccgtg      900

ctggctgata ttctggctgg cggagagtac gagggcagac cttgtctgtg cgtggccaaa      960

gtgaacacct acgagaagca caggcaggac ctgcggctgc tgaaaaagct cgtgcgggaa     1020

tactgccccg aggactacaa gagctggttc agcgtgcccg tgaacgacaa ctactgtgcc     1080

tacatcggca ccttcagaaa gaacggcaag agatgcgaga caaagcggtg caatcaagag     1140

acattctaca aggccctgaa gaaactgctg ggcaagatga gcgccgatct gcctgaagcc     1200

gccgacatcc tgaaagagac agagaacggc acctttctgc ccctgcaagt gtccaaggac     1260

aacggcgtga tcccctacca ggtgcacaag atggaactcg agagaatcct ggaccacgcc     1320

gagaagtacc tgcctttcct gctggaaaag gaccccgagt gtggcaagac agtgcgggaa     1380

aagatcgtgg ccctgttcga gttcagaatc ccctactacg tgggccctct gaataccgcc     1440

gctggcgaga attgctggat ggaaagaaaa gaagagggcg ccgtcagacc ctggaacttc     1500

gatcagaagg tggacagaga caagagcgcc gagagattca tcagacggat gaccaaccag     1560

tgtacctacc tgatccacga gacagtgctg cccaagcaca gcctgctgta ctccgagttc     1620

atggtgctga acgagctgaa caacgtgaag atccgggacg agaagctgcc cgtggaactg     1680

aagcagggaa tcgtgcagaa gctgttcaag acccggaagc aagtgaccgg cagaaagctg     1740

ctggactacc tgaccgccaa cggctacgac gtgaagaagg atgagctgag cggcttcgac     1800

ggcaacttta aggccagcct gaccagctac cacacgctga agaagatctt tggcaaagag     1860

cttgagaagt ccagcgtgca gcagatggcc gaggacatca tcctgtggat caccctgtac     1920

ggcgaggacc agaaaatgct gtgcagagtg atccggcagc actacggcga gattctgaaa     1980

gaagaacagc tgaaagaact gagccggctg aagtttcaag gctggggcag actgagcaga     2040

cggttcctga atgaactgga aggcgtggac tgtaccaccg gcgagtgcat gacaatcatg     2100

cagggcctga gaaacaccca gaacaacctg atgcagctgc tgagccagca gtacaccttc     2160

gccagaatga tcgacgacga gaacggcggc tatcacgtgg acgagatcac ctacgacaac     2220

ctggtcaagg acatcgtggc aagccctagc attaagaggg ccgtgtggca gaccatccag     2280

atcgtggaag aactgaagaa cgtgatgggc tgcgagccca agaaagtgtt cgtggaaatg     2340

gccagaggcg aggaagagaa gcgcagaacc gtgtccagaa aggacaagct gcttgaggcc     2400

tacgccgcca tcaaggatga ggccagagat tggcaagagg aactgcagaa gtacagcgag     2460

ggcgacctga aggccatcaa gctgtacctg tactacaccc agatgggcca gtgcatgtac     2520

accggcaaga agatcgagct gtcccagctc aacaacgcca ccatctggga cagagatcac     2580

atctaccctc agagcaagac caaggacgac agcctggaca atctggtgct ggtggatcgg     2640

agagtgaacg ccaagaaaag cgacggcatg atcagccccg agatccagca gaagatgaga     2700

ggcacctgga agtacctcaa agagaagggc ctgatcagcg agaagaagta cgagcggctg     2760

accagaacca cacctctgac cgaagaagaa ctggctggct tcatcaacag acagctggtg     2820

gaaacccggc agagcagcaa agtggtggcc actctgctga agcggatcta cgaagaggcc     2880

gagatcgtgt acgtgaaggc caaggccgtg tccgacttcc ggaaagagca cctgaaatac     2940

gtcaaagtgc gggacctgaa cgactaccac cacgccaagg atgcctacca gaacatcgtc     3000

gtgggcaacg tgtaccacac caagttcacc ggcaatcctc tgcggtggct gaaagagcat     3060

cccgagagaa agtacagcct gaaccagatg ttcaactacg atctcgaggt gcacggcaag     3120

cccgtgtgga aaagaggcaa ggacggcagc atcagatgcg tgtccgagac actgaagagg     3180

aacgacatcc tctttacccg ctacgccttc tgcaacaaag gcggcctgtt caaccagacc     3240

atcatgaagg ctcccgagga caaggccaaa gccaaaggcc tggtgcctat caagaaggga     3300

aagaaccccg agaaatacgg cggctttacc agcgtgaccc ctagccactt tatgctggtg     3360

gcctctgagg gcaagaaagg caaagagatc cggaccatcg agactgtgcc cctgtacaga     3420

aagaaagagt tcgagagaga gcctgagctg ctgctccagt actgcagaga gttctacggc     3480

ctgaagaacc ctagaatcct gatctcctgc atcaagaaga acgcccggct ggtcatcaac     3540

ggcttcccta tgcatctgaa gggctctacc ggcaagcagc tgattctgca gggtgcagtg     3600

cagctgtgcc tggatgatga gaaggtggtg tacctgaaaa aagtgaccaa ctacctcgag     3660

gaaaacgcca gacggaagga caagagaaca ctgctggaag tgaaagagat taccggcatc     3720

accagcgagg ccaacatcaa cctgtacgac ctgttcatta agaagctgag cagcacgatc     3780

taccagtaca gacccgccaa tcctaaggat aacctgctga aaggccgcga gaagttcctg     3840

aacctgggac ttgctgagca gtgtgtggtg ctgggagaga tcctgcacct gttccagtgt     3900

aaacccctga gcgccaacct gatcctgatc ggagccgctg gaaataccgg cgtgaccaag     3960

atcggaaaag aaatcagccg gtgcaacagc gccaagctgg tgtctcagtc tgtgacaggc     4020

atctacgaac aggtggtgga tctgctgacc atcggatcc                            4059


<210>  1564
<211>  3243
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-291 Codon optimized for human cells

<400>  1564
ggtacccagt ggccttatgg cgttggcctg gatatcggag tggcctctat tggatgggcc       60

accgtggctc tggatgagaa agctcagcct tgcggcctga tcagactggg cagcagagtg      120

tttaagagag ccgagcagcc taagaccggc gaatctctgg ctgcccctag aagagaagcc      180

agaggcatgc ggagaaggct gagaagaagg gccctgcgga agcaggattt ctaccagctg      240

ctggaaaaga accatctgcc tgacaaagag gaactgagca gactgtttgc cgctggcggc      300

ctggaagata tctacgccct gagaactaga gccctggacg aggctgtgac ccctcaagag      360

tttgccagaa tcctgctgca cctgatgcag cggagaggct tcaagtctaa cagactggcc      420

ggcaagagca agaaagacgg cgttctgctg caggccgtga cacagaacca gctgagaatg      480

caagagaacg gctaccggac agtgggcgag atgctgtaca aagatcctct gttcgccgcc      540

tgcaagcgga acaagggcga gaattacctg agcaccgtgt ccagagagga aatcgccaac      600

gaggctcagc tgctgtttga ggcccagaga gagaagggca gagattgggc cacacctgag      660

ctggaagccg agtacctgtc tatcctgctg agacagcgga gcttcgatca aggccctggc      720

ggcaattctc cttacaaagg cggatgggcc gagagagtgg gaccttgtac actgctgcct      780

gaggaaaagc gggccttcaa gaacacctac agcttcgaga gattcaccct gctgcagaag      840

atcaacaaca tccggatcgt ggaaagcggc cagacacagg ccctgagcga cgaagaaaga      900

cagaaagtga tggacctggc ctacagagtg gaaaccgtgc cttacacact gatccggaaa      960

gaactgcagt ggccccagac catcagattt gccgacgtcc gctacgatgt ggatgccgct     1020

cctgaagccg ccgagaagaa gtgcaaactg cctcctatga agggctacca cgctctgaga     1080

aaagccctgg gaacaagaca ggccgagctg cctctgtggg acgatgtgat tacaatcctg     1140

gccagccaca gagatgaagg cgtgcggaag aaactgctgg aagaaaaggg cctgaccgcc     1200

gaacaggtgg aagctgtgct gggactcgaa ttttctggcg tgggccacat cagcctgaag     1260

gcctgtcaaa tgctggaacc atggctgctc cagggcctga agtacgatca ggcctgttct     1320

aaggccggac tggacttcag aggccacagc aacatcaaga aaacccctaa gctgcccgcc     1380

agcgctcccg agctgaagga tattacatct cctgtcgtgc ggagagccgt gtctcagaca     1440

atcaagctgg tcaacgccat catcagagag atggaacagc ctcctgtgtg gattcacatc     1500

gagctggcca gagagctgag ccggaccttc gaagaacggc ggagagatca gaaatccatg     1560

gaagataacg cccggcagaa cgagtgcctg atgcaagaaa tccgggacac cttccacaag     1620

ctgaacccta ccggccagga cctgatcaag taccggctgt ggaaagagca ggacggcatc     1680

tgcgcctact ctcagcagtc tatcgccgtg gaaagactgt tcgagacagg ctatgccgag     1740

gtggaccaca tcgtgcccta cagcatcagc ttcgacgaca gcagatccaa caaggtgctg     1800

gtcatggccg ccgaaaacca ccagaagggc aatagactgc ccctgcagta cctccagggc     1860

gagagaagag aaaagttcat cgtgtggacc aagagccaag tgcggaacta ccggaagcag     1920

aagaacctgc tgcgcgagac agtgtccgag gaagaacaga acggcttcaa gcagcggaac     1980

ctgcaggaca cccagtacat ggcccggttt ctgctgaact acatcaggga tcacctggcc     2040

ttcgccgatc atcctgccgc tggaaaacag cgagttatgg ctctggctgg cgccgtgaca     2100

agccacctga gaaaaagatg gggactgacc aaagtccgcg ccgacggcga tctgcatcat     2160

gcactggatg ctgccgtgat cgcctgtgcc acaaaaggca tggtgcagca aatcagcggc     2220

tactaccacc ggatcgaggg cgaataccag cagtcctctg atggcacata cagcgtgcac     2280

accagaaccg gcgaagtgtt tcctgctcct tggcctcact tccgggacga gctgattcag     2340

agactgtccc agaagcctca agagaacctc atgcagtgga accccgtgtt ctacagcaac     2400

ttcgacgtgg aatccatcag acccgtgttc gtgtccagga tgccccagca caaagtgaca     2460

ggcgccgctc acaaagaaac catcaagagc cccaaggctc tgcaggatgg cctgctgatt     2520

gtgaagcacc ctctgaccga cctgaagctg aacaagaaaa caggcgagat cgaggggtac     2580

taccagccta gcagcgacaa gctgctgtac gaagctctga gagcccgcct gctggaattt     2640

ggcggagatg gcaagaaggc ctttaccgag cctttctaca agcccaagtc cgacggaaca     2700

cctggacctc tcgtgcggaa agtgaaactg tgcgagaagg ccagcctgtg tgtgcctgtt     2760

catggtggaa acggcgctgc cgacaacgat tctatggtcc gagtggacgt gttcttcgtg     2820

cccggcgacg gctactatat ggtgcccatc tacgtgtccg acaccaagaa gaaagagctg     2880

cccaatagag ccgtggtggc ccacaaagag ttcagcgcct ggaaagttat ggaagagaag     2940

aatttcctgt tcagcctgta cgccgacgac ctgattgagg tggcccggaa aaaagtgatg     3000

cccttcacca tcgtgaacag cggcagcaca ctgcctccaa gctacgagac aacccacgag     3060

atggtgtact acggcggact ggatatcagc agcggcaata tcaaagtgac catccacgac     3120

aacagctact ccctgagagg cctgggcatc aagaccctga acaccctgca gaaatatgag     3180

gtggacatcc tgggcaacgt gcgggaagtc aagaaagaga agcggcagtc cttccgggga     3240

tcc                                                                   3243


<210>  1565
<211>  3300
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-308 Codon optimized for human cells

<400>  1565
ggtaccgcct atgccatcgg cctggatatc ggaatcgcct ctgtgggata tgccgtggtg       60

gccctggact acgaggaaaa cccttggggc atcatcaaca tgggcagcag aatcttcgac      120

gccgccgaga atcctaagga tggcgcttct ctggccgctc ctagaagaga agctagaacc      180

ggcagacggc ggctgcggag aagaaagcac agaatcgagc ggatcaagaa cctgttcctg      240

aacacccagc tgctgaccaa agagcagctg gaaaagctgt acgagggcgt gctgtccgac      300

gtgtacgagc tgagagtgaa aggcctggat gagaagctga cagccgaaga ggtggccaga      360

gttctgctgc atctggccca cagaagaggc ttcaagagca accggaaggc cgagaaaacc      420

gacaaagaga atggcgccct gctgaccgcc gtgtccgaga accagaaacg gatgaaggac      480

aagcagtacc ggaccatcgg cgagatgttc cacaaggatg agctgttcgc cgagtacaag      540

cggaacaaag gcggcaccta tctgaccacc gtggccaggg aaatgatcgc cgacgaggcc      600

aagtacatca ttgccacaca gcggagcttc ggcaacaaga ccctgaccat cgagttcgag      660

gaaagctacc tggacatcct gctgagccag cggaactttg atgaaggccc tggcggcaat      720

agcccttacg gcggagatca gatcgagaga atgatcggca actgcacctt cgagaagtcc      780

gagaagagat gcgccaagag ctgctacagc ttcgagtact tcaacctgct gcagaagatc      840

aaccacctga gactgctggt ggacggcgtg aaggtggaac tggatggcag ccagaaaagc      900

aaagtgatca acctggccaa gaccaaggcc gacctgaagt acagccagat ccggaaagaa      960

ctcggcctgg gcagccaggt gctgttcaat gccctggtgt acaacagcga cgtggaagaa     1020

gtggaaaaga agtccaagtt caacttcatg cccgcctacc accagattag aaaagaactg     1080

gacaccgtgg tcaaaggccg gatcgaggcc atcgacatcg atacactgga cgagatcggc     1140

agaatcctga gcacctacaa gagcgacgcc aagagaatcg aggccttcag caacctgaac     1200

atcaccagca aggacatgga agccctgctc aacatcaacg gcctgagaaa gtttggccac     1260

ctgagcctga aagccctgaa gaagatcacc ccatttctgg aacagggcat gatctacaac     1320

gaggcctgta cagccgccgg atacgagttt agaggccaca gcggctacga aaagaccttc     1380

ctgctgccta gccagaccga agagatggaa aacgtgacat ctcctgtggc caggcggagc     1440

atcagccaga gcatcaaagt gattaacgcc atcatcagag agcagggcga gagccctctg     1500

tacatcaatg tcgaactggc ccgcgagatg gccaaggact tcgacgagcg gaagaagatt     1560

aagaaagaga cagacgagaa tcaggcccgg aacgagcggc tgatcgagaa gatcagaaac     1620

gagtttcaca agcagaaccc caccggcctg gacctggtta agctgaagct gtgggaagaa     1680

caggatggcg tgtcccctta ctctcagaaa cagatcgtga tcgagaggct gttcgagccc     1740

ggctatgtgg acgtggacca catcgtgcct tacagcatca gcttcgacga caccatgaag     1800

aacaaggtgc tggtgttcgc cagcgagaac cgcgagaagg gcaagaatct gcccgtggaa     1860

tacctggcca gaaaaaaggg ccagaaagcc gtggacgact tcaaagtgtg ggtcacctcc     1920

aacgtgcgga actacaagaa gcggctgaac ctgctgaagt ccgaagtgac cgaggaagat     1980

ctgaacaagt tcaaagagcg gaacctgcag gacaccaaga ccatcagccg gttcatgtac     2040

aactacatca gcgaccacct gatcttcgcc cctagcgaga caggcaagaa gaaaagggtc     2100

accgccgtga acggcgccat cacctcctat ctgagaaagc gctggggaat caacaaagtc     2160

cgcgccgatg gcgataagca ccatgccgtg gatgccctcg tgatcgcctg taccaccgac     2220

aagctgatca aggacctgag ctaccacagc cggtatctgg aaatggaata cgaggccggc     2280

gagaaagaaa gcctgtgggt caacagaaac accggcgaga tcgtgaagcg gttcccctat     2340

ccttgggaag atttcagagc cgagctgatg gccagactgt ctgatgcacc tgaagtggcc     2400

ctgcggaaac tgcagctgct gtactaccag gacaaggacc tcagcaagat caagcccatc     2460

ttcgtgtcca gaatgcctcg gagaaagatc accggcgctg cccacaaagc tacagtgcgg     2520

ggagccagat atgtggacaa gggcatcgtg atcagcaaga agtccctgag cgagctgaag     2580

ctcaacaaag gtggcgagat cgagaactac ttcgcccctg agagcgacag actgctgtat     2640

gaggccctga aagaacagct gaagaagttt aacggcaacg ccaagaaggc tttcgagcag     2700

ggattctaca agcctaaggc cgacggcacc cctggaccta aagtgaacaa agtgaaggtg     2760

tacgacaaga gcaccctgaa cgtggccgtt caacaaggca caggcgccgc tgacaacgat     2820

tctatggttc gagtggacgt gtacaaggtg gaaggcgacg gctactacct ggtgcctatc     2880

tatgtggccg acacactgaa gaaagagctg cccaacaagg ccattgtgca gggcaagacc     2940

tacgagcagt ggaaagagat gagccccgag gacttcgtgt tctctctgta ccccaacgac     3000

ctgatcaaga tcacgcacaa gaaagaaatc aacttcagcc gggtgtccga ggacagcaca     3060

ctggccgata gctacaagac caaagaagag ttcgtctact acaaaaagac cagcatctcc     3120

accgcctcca tcagcatcat taacaacgac aacacctaca caatccccag cctgggcgtg     3180

aaaacactgg ccagcctgga aaagtaccag gtggacattc tgggcaacta caccaaagtg     3240

ggcaaagaaa agctgcagac cttcgccgcc tatcagcagg ccaagaaaaa gcccggatcc     3300


<210>  1566
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-103 sgRNA scaffold

<400>  1566
guuugagagu aguguaagaa auuacacuac aaguucaaau aaaaauuuau ucaaauccau       60

uugcuacauu guguagaauu uaaagaucug gcaacagauc uuuuuuu                    107


<210>  1567
<211>  119
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-124 sgRNA scaffold

<400>  1567
guuuaaguac cuggagaaag aaauuucuuc agaccuacuu aaauaaggau uuauuccgaa       60

agaauuauug uaaaugaaga aaauaaggcg agaaaggaug cugacgggca uccuuuuuu       119


<210>  1568
<211>  87
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-127 sgRNA scaffold

<400>  1568
guuuaguuac cauauggaug aaaaucuaua ugaccuaacu aaacaagggu uuaucccgga       60

uucggcuccu uuauaggagc cuuuuuu                                           87


<210>  1569
<211>  92
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-218 sgRNA scaffold

<400>  1569
guugugguuu gaugaugaaa aucaucaaau cacaauaagg cuauaugccg aaggaugaau       60

uccuaucgcc ucucuucugg agaggcuuuu uu                                     92


<210>  1570
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-237 sgRNA scaffold

<400>  1570
guuugagagu aguguaagaa auuacacuac aaguucaaau aaaaauuuau ucaaauccuu       60

cugcugcauu gugcagaauc uaaagaucug gaaacagauc uuuuuuu                    107


<210>  1571
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-291 sgRNA scaffold

<400>  1571
guuguagcuc ccugacagug aaaacuguca ugguugcuac aauaagguag uauaccguaa       60

agcucugacg cccugcuugc agggcgucau cuuuuuuu                               98


<210>  1572
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-308 sgRNA scaffold

<400>  1572
guuguaguuc ccuaauuuug aaaauuauua gguuacuaug auaagguagu acaccgaaaa       60

gcucuaacgc ucugucuugg acagagcguu aucuuuuuu                              99


<210>  1573
<211>  6373
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pET9a-OMNI-103

<400>  1573
taatacgact cactataggg agaccacaac ggtttccctc tagagagaca ataaccctga       60

taatgcttca ataatattga aaaaggaaga gtatgcctaa gaagaagaga aaggtgggta      120

cctctatcaa gagcgactac ttcctgggcc tcgacatcgg cacagattct atcggatggg      180

ccgtgacaga ccccgagtac cacatcctga gaagaaaggg caaagccctg tggggcatca      240

gactgttcga tgccgccaat actgccgccg agagaagaac cttccggacc agcagaagaa      300

gaatccagcg gcggagacag cggatcagac tgctgcaaga gctgttcgcc gaggaaatgg      360

ttaagctgga ccccggcttc ttccagagac tgagcgatag cgccttctgg caagaggaca      420

agcaagagca gcagatctac agcctgttta cctgcgagaa ctacaccgac gtggactact      480

acagagagta ccccaccatc taccacctga gaagcgccct gatccaagag aaaaaagagt      540

tcgacctgcg gctgctgtat ctggccctgc accatctgat gaagcaccgg ggccactttc      600

tgttcaacgg cagcatcaac aacgtgacca gcttccacac caccttccag accttcgccg      660

actgcctgta cgacgagttc gacatcgagc tggaatgcga cagcgaggac agattcgccg      720

agatcctgaa ggataagcac gccagaaaga ccggcaagtg ctctgagctg gaaatcatct      780

gccacatcga gaagtccaac aagcagctga aagaactgtt caagctgatc accggcatga      840

aggccagcct gagcgtggtg tttggagatg atgagctggc cgagatcgag cacaacaaga      900

tcagcttcag cgagagcagc tacgacgaag tgcggctggc cctggaagat gagattcaag      960

agagaaccgg catcctggac atcttccacg ccgtgtattc ttgggccatc ctggccgata     1020

ttctggaagg cggcgagtac gagggcaaca gctatctgtc tgtggccaag gtgtccacct     1080

acaagaagca cggcgacgac ctgagactgc tgagaacact cgtgcgcgag tactgccccg     1140

accactacaa gagctttttc agcgtgtccg gcaaagagaa ctactgcgcc tacgccggca     1200

cactgaagaa gaacggcaag aagcagccca tcaagcggtg cagccaagag gacttctaca     1260

aggccctgaa gaaactgctg aaccagatgc ctaccgagca gcccgaagtg aaggatatct     1320

tcatcgagat tgagaacggc accttcctgc ctctgcaagt gtccaaggac aacggcgtga     1380

tcccctacca agtgaacaag atggaactcg agaagatcct gcagaacgcc gaagagtacc     1440

tgcctttcct gaagaacatc gacgaggaat gcggcaagac cgtgtccaag aagatcatcg     1500

acctgttcga gttcagaatc ccctactacg tgggccctct gaataccgcc aagggcgaga     1560

attgctggat ggttcgaaaa gaggccggca gaatctaccc ctggaacttc gatgagaagg     1620

tggacagaga tcagagcgcc gagaagttca tcagacggat gaccaaccag tgcacctacc     1680

tgatccacga ggacgtggtg cctaagaaca gcctgctgta ctccgagttc atggtgctga     1740

acgagctgaa caatgtgaag attcggagcg agaagctgcc cgtggaactg aagcaggcca     1800

tcgtgctgga cctgtttaag aagcagaagc agatcacagg gaagaagctg ctcaactacc     1860

tgaacgccaa cggctacgac gtgaagaaag aggacctgag cggcttcgac ggcaacttca     1920

agtccagcct gtccagctac ctgactctga agaaggtgtt cggagaggaa ctggacaagt     1980

acagcgtgca gcagatggcc gaggacatca tcctgtggat caccctgtat ggcgacgatc     2040

agaaaatgct gcggagagtg atccggaagc actacgagca gcagctgtct gaggaacaga     2100

tcctgagcct gagcaagctg aagttccaag gctggggcag actgtctaga cggctgctct     2160

ctgaaatgga aggcgtggac tgtgaaaccg gcgagtgcat gacagtgatg cagggcctga     2220

gaaacaccca gaacaacctg atgcagctgc tgagccagca gttcagcttc atggaactga     2280

tcgaggaaga gaacgggaac tactacgtcg acgagatcac ctacgacaac ctggtcaagg     2340

acatggtcat cagccctagc gtgaaaaggg ccgtgtggca gacagtgcag atcgtggaag     2400

aaatcaaggg cgtgatggga tgccagccta agaaaatctt cgtggaaatg gcccgcagcg     2460

acgaagagaa gaaacggacc gtgtctcgga aggatcggct gctggaagcc tacgacgcca     2520

tcaaggatga ggcccggcaa tggcaagaag aactgcagaa atactccgac ggcgatttca     2580

aggccatcaa gctgtacctg tactacaccc agatgggcca gtgcatgtac accggcagaa     2640

aaatcgatct gtcccagctg aacgacgcca ccgtgtggga tagagatcac atctaccctc     2700

agagcaagac caaggacgac agcctggaca atctggtgct ggtggataga tccgtgaatg     2760

ccaagaaaag cgacggcatg ctgagccccg agatccagca gagaatgaga gccacctgga     2820

agtacctgaa agaaaagaag ctcatcagcg agaagaagta cgagcggctg accagagtgt     2880

cccctctgac agatgaagaa ctggccggct tcatcaaccg gcagctggtg gaaacaagac     2940

agagcagcaa agccgtggcc acactgctga agagggtgta cgatgaggcc gagattgtgt     3000

atgtgaaggc cgaggccgtg tctaacttcc ggcgggataa cctggactac atcaaagtgc     3060

gggacctgaa cgactaccac cacgccaagg acgcctacca gaacatcgtc gtgggcaacg     3120

tgttccacga gaagtttacc agcaatcccc tgcggtggct gaaaaacaac cccaacacca     3180

agtactccct caaccagatg ttcaacttcg acctggaaaa gaacggcgtg gtcatctgga     3240

agagaggcaa ggccggctcc attaagtgtg tggaagagac actgaagcgg aacgacatcc     3300

tgttcaccag atacgctttc tgcaacaaag gcggcttctt taatcagatg ctgaccgccg     3360

ctccagagga taagacaaag gccaaaggcc tggtgcctat caagaaaggc atggaaacct     3420

ggaaatacgg cggctacacc agcgtgaccc ctagccactt tatgctggtg gccagcaagg     3480

acaagaaggg aaaagagatc cggaccatcg agacagtgcc cctgtaccgg tggaaagagt     3540

tcaaagagaa tcccgacgct ctgctccagt actgcagaga gttctacggc ctgaaagagc     3600

ccaaggttct gatcccttgc atcaagaaga atgcccggct ggtcgtgaac ggcttcccta     3660

tgcacctgaa gggcagcacc ggaaaacagc tgattctgca gggtgccgtg cagctgtgcc     3720

tgaacaacga gaacatcaag tacctcaaga aagtgacgaa gtacctcgag tacaacgccc     3780

agcggagaga caagagaacc ctgctcgaag ttcgggaagt gaccggaatc aacaaagagg     3840

aaaacatcca gctgtacgat gtgttcgtgg acaagctgag caacacaatc taccagtaca     3900

gacccgccaa tcctaaggac aacctcatca agggccgcga gaaattcatc gagcttggcc     3960

tggctgagca gtgcgtggtg ctgggagaag tgctgcatct gttccagtgc aagcccctga     4020

ccagcgatct gacactgatc ggcggaagcc ctaacaccgg caccatcaag atcaccaaga     4080

ccatcagcaa ctgcaacgtg gtcaagctgc tgtcccagtc tatcgccggc gtgaaagtcc     4140

gcgagatcaa cctgctgatc atcggatcct acccatacga tgttccagat tacgcggccg     4200

ctccaaaaaa gaaaagaaaa gttgcggcta gccatcatca ccatcaccat catcattaag     4260

gctgctaaca aagcccgaaa ggaagctgag ttggctgctg ccaccgctga gcaataacta     4320

gcataacccc ttggggcctc taaacgggtc ttgaggggtt ttttgctgaa aggaggaact     4380

atatccggat atccacagga cgggtgtggt cgccatgatc gcgtagtcga tagtggctcc     4440

aagtagcgaa gcgagcagga ctgggcggcg gccaaagcgg tcggacagtg ctccgagaac     4500

gggtgcgcat agaaattgca tcaacgcata tagcgctagc agcacgccat agtgactggc     4560

gatgctgtcg gaatggacga tatcccgcaa gaggcccggc agtaccggca taaccaagcc     4620

tatgcctaca gcatccaggg tgacggtgcc gaggatgacg atgagcgcat tgttagattt     4680

catacacggt gcctgactgc gttagcaatt taactgtgat aaactaccgc attaaagctt     4740

atcgatgata agctgtcaaa catgagaatt cttagaaaaa ctcatcgagc atcaaatgaa     4800

actgcaattt attcatatca ggattatcaa taccatattt ttgaaaaagc cgtttctgta     4860

atgaaggaga aaactcaccg aggcagttcc ataggatggc aagatcctgg tatcggtctg     4920

cgattccgac tcgtccaaca tcaatacaac ctattaattt cccctcgtca aaaataaggt     4980

tatcaagtga gaaatcacca tgagtgacga ctgaatccgg tgagaatggc aaaagcttat     5040

gcatttcttt ccagacttgt tcaacaggcc agccattacg ctcgtcatca aaatcactcg     5100

catcaaccaa accgttattc attcgtgatt gcgcctgagc gagacgaaat acgcgatcgc     5160

tgttaaaagg acaattacaa acaggaatcg aatgcaaccg gcgcaggaac actgccagcg     5220

catcaacaat attttcacct gaatcaggat attcttctaa tacctggaat gctgttttcc     5280

cggggatcgc agtggtgagt aaccatgcat catcaggagt acggataaaa tgcttgatgg     5340

tcggaagagg cataaattcc gtcagccagt ttagtctgac catctcatct gtaacatcat     5400

tggcaacgct acctttgcca tgtttcagaa acaactctgg cgcatcgggc ttcccataca     5460

atcgatagat tgtcgcacct gattgcccga cattatcgcg agcccattta tacccatata     5520

aatcagcatc catgttggaa tttaatcgcg gcctcgagca agacgtttcc cgttgaatat     5580

ggctcataac accccttgta ttactgttta tgtaagcaga cagttttatt gttcatgacc     5640

aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa     5700

ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca     5760

ccgctaccag cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta     5820

actggcttca gcagagcgca gataccaaat actgtccttc tagtgtagcc gtagttaggc     5880

caccacttca agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca     5940

gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta     6000

ccggataagg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag     6060

cgaacgacct acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt     6120

cccgaaggga gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc     6180

acgagggagc ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac     6240

ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac     6300

gccagcaacg cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgttc     6360

gatcccgcga aat                                                        6373


<210>  1574
<211>  2783
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pShuttle Guide-T2-OMNI-103 V2

<400>  1574
tacacggtgc ctgactgcgt tagcaattta actgtgataa actaccgcat taaagcttat       60

cgatgataag ctgtcaacac atttccccga aaagtgccac ctgacgtcct cgagtcccgc      120

ataatcgaaa tgagggccta tttcccatga ttccttcata tttgcatata cgatacaagg      180

ctgttagaga gataattaga attaatttga ctgtaaacac aaagatatta gtacaaaata      240

cgtgacgtag aaagtaataa tttcttgggt agtttgcagt tttaaaatta tgttttaaaa      300

tggactatca tatgcttacc gtaacttgaa agtatttcga tttcttggct ttatatatct      360

tgctaatacg actcactata ggaagagcag agccttggtc tcgtttgaga gtagtgtaag      420

aaattacact acaagttcaa ataaaaattt attcaaatcc atttgctaca ttgtgtagaa      480

tttaaagatc tggcaacaga tctttttttg aattctctag cataacccct tggggcctct      540

aaacgggtct tgaggggttt tttgacctag gctaggggat atattccggg taccccgctt      600

cctcgctcac tgactcgcta cgctcggtcg ttcgactgcg gcgagcggaa atggcttacg      660

aacggggcgg agatttcctg gaagatgcca ggaagatact taacagggaa gtgagagggc      720

cgcggcaaag ccgtttttcc ataggctccg cccccctgac aagcatcacg aaatctgacg      780

ctcaaatcag tggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg      840

cggctccctc gtgcgctctc ctgttcctgc ctttcggttt accggtgtca ttccgctgtt      900

atggccgcgt ttgtctcatt ccacgcctga cactcagttc cgggtaggca gttcgctcca      960

agctggactg tatgcacgaa ccccccgttc agtccgaccg ctgcgcctta tccggtaact     1020

atcgtcttga gtccaacccg gaaagacatg caaaagcacc actggcagca gccactggta     1080

attgatttag aggagttagt cttgaagtca tgcgccggtt aaggctaaac tgaaaggaca     1140

agttttggtg actgcgctcc tccaagccag ttacctcggt tcaaagagtt ggtagctcag     1200

agaaccttcg aaaaaccgcc ctgcaaggcg gttttttcgt tttcagagca agagattacg     1260

cgcagaccaa aacgatctca agaagatcat cttattaatc agataaaata tttctagatt     1320

tcagtgcaat ttatctcttc aaatgtagca cctgaagtca gccccatacg atataagttg     1380

ttactagtgc ttggattctc accaataaaa aacgcccggc ggcaaccgag cgttctgaac     1440

aaatccagat ggagttctga ggtcattact ggatctatca acaggagtcc aagcgagaag     1500

ggttggtttg cgcattcaca gttctccgca agaattgatt ggctccaatt cttggagtgg     1560

tgaatccgtt agcgaggtgc cgccggcttc cattcaggtc gaggtggccc ggctccatgc     1620

accgcgacgc aacgcgggga ggcagacaag gtatagggcg gcgcctacaa tccatgccaa     1680

cccgttccat gtgctcgccg aggcggcata aatcgccgtg acgatcagcg gtccaatgat     1740

cgaagttagg ctggtaagag ccgcgagcga tccttgaagc tgtccctgat ggtcgtcatc     1800

tacctgcctg gacagcatgg cctgcaacgc gggcatcccg atgccgccgg aagcgagaag     1860

aatcataatg gggaaggcca tccagcctcg cgtcgcgaac gccagcaaga cgtagcccag     1920

cgcgtcggcc gccatgccgg cgataatggc ctgcttctcg ccgaaacgtt tggtggcggg     1980

accagtgacg aaggcttgag cgagggcgtg caagattccg aataccgcaa gcgacaggcc     2040

gatcatcgtc gcgctccagc gaaagcggtc ctcgccgaaa atgacccaga gcgctgccgg     2100

cacctgtcct acgagttgca tgataaagaa gacagtcata agtgcggcga cgatagtcat     2160

gccccgcgcc caccggaagg agctgactgg gttgaaggct ctcaagggca tcggtcgacg     2220

ctctccctta tgcgactcct gcattaggaa gcagcccagt agtaggttga ggccgttgag     2280

caccgccgcc gcaaggaatg gtgcatgcaa ggagatggcg cccaacagtc ccccggccac     2340

ggggcctgcc accataccca cgccgaaaca agcgctcatg agcccgaagt ggcgagcccg     2400

atcttcccca tcggtgatgt cggcgatata ggcgccagca accgcacctg tggcgccggt     2460

gatgccggcc acgatgcgtc cggcgtagag gatccacagg acgggtgtgg tcgccatgat     2520

cgcgtagtcg atagtggctc caagtagcga agcgagcagg actgggcggc ggccaaagcg     2580

gtcggacagt gctccgagaa cgggtgcgca tagaaattgc atcaacgcat atagcgctag     2640

cagcacgcca tagtgactgg cgatgctgtc ggaatggacg atatcccgca agaggcccgg     2700

cagtaccggc ataaccaagc ctatgcctac agcatccagg gtgacggtgc cgaggatgac     2760

gatgagcgca ttgttagatt tca                                             2783


<210>  1575
<211>  5009
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pbPOS T2 library


<220>
<221>  misc_feature
<222>  (3040)..(3047)
<223>  n is a, c, g, or t

<400>  1575
tcgagtcttt acactttatg cttccggctc gtatgttgtg tggaattgtg agcggataac       60

aatttcacac atgattacgg attcaacgtc gtgactggta aaacccgggc gttacccaac      120

ttaatcgcct tgcagcacat ccccctttcg ccagcaggcg taataaggaa aggattcatg      180

tactatttga aaaacacaaa cttttggatg ttcggtttat tctttttctt ttactttttt      240

atcatgggag cctacttccc gtttttcccg atttggctac atgatatcaa ccatatcagc      300

aaaagtgata cgggtattat ttttgccgct atttctctgt tctcgctatt attccaaccg      360

ctgtttggtc tgctttctga caaactcggt ctacgcaaat acctgctgtg gattattacc      420

ggcatgttag tgatgtttgc gccgttcttt atttttatct tcgggccact gctgcagtac      480

aacattttag tagggtcgat tgttggtggt atttatctag gctttagttt taacgccggt      540

gcgccagcag tagaggcatt tattgagaaa gtcagccggc gcagtaattt cgaatttggt      600

cgcgcgcgga tgtttggcag tgttggctgg gcgctggttg cctcgattgt cgggatcatg      660

ttcaccatta ataatcagtt tgttttctgg ctgggctctg gcagttgtct catcctcgcc      720

gttttactct ttttcgccaa aacggacgcg ccctcaagtg ccacggttgc caatgcggta      780

ggtgccaacc attcggcatt tagccttaag ctggcactgg aactgttcag acagccaaaa      840

ctgtggtttt tgtcactgta tgttattggc gtttcctcca cctacgatgt ttttgaccaa      900

cagtttgcta atttctttac ttcgttcttt gctaccggtg aacagggtac ccgcgtattt      960

ggctacgtaa cgacaatggg cgaattactt aacgcctcga ttatgttctt tgcgccactg     1020

atcattaatc gcatcggtgg gaagaatgcc ctgctgctgg ctggcactat tatgtctgta     1080

cgtattattg gctcatcgtt cgccacctca gcgctggaag tggttattct gaaaacgctg     1140

catatgtttg aagtaccgtt cctgctggtg ggctccttta aatatattac tagtcagttt     1200

gaagtgcgtt tttcagcgac gatttatctg gtcagtttca gcttctttaa gcaactggcg     1260

atgattttta tgtctgtact ggcgggcaat atgtatgaaa gcataggttt ccaaggcgct     1320

tatctggtgc tgggtctggt ggcgctgggc ttcaccttaa tttccgtgtt cacgcttagc     1380

ggcccgggcc cgctttccct gctgcgtcgt caggtgaatg aagtcgctta aaggcctcga     1440

tgcagctagc atgctaatct gattcgttac caattatgac aacttgacgg ctacatcatt     1500

cactttttct tcacaaccgg cacggaactc gctcgggctg gccccggtgc attttttaaa     1560

tacccgcgag aaatagagtt gatcgtcaaa accaacattg cgaccgacgg tggcgatagg     1620

catccgggtg gtgctcaaaa gcagcttcgc ctggctgata cgttggtcct cgcgccagct     1680

taagacgcta atccctaact gctggcggaa aagatgtgac agacgcgacg gcgacaagca     1740

aacatgctgt gcgacgctgg cgatatcaaa attgctgtct gccaggtgat cgctgatgta     1800

ctgacaagcc tcgcgtaccc gattatccat cggtggatgg agcgactcgt taatcgcttc     1860

catgcgccgc agtaacaatt gctcaagcag atttatcgcc agcagctccg aatagcgccc     1920

ttccccttgc ccggcgttaa tgatttgccc aaacaggtcg ctgaaatgcg gctggtgcgc     1980

ttcatccggg cgaaagaacc ccgtattggc aaatattgac ggccagttaa gccattcatg     2040

ccagtaggcg cgcggacgaa agtaaaccca ctggtgatac cattcgcgag cctccggatg     2100

acgaccgtag tgatgaatct ctcctggcgg gaacagcaaa atatcacccg gtcggcaaac     2160

aaattctcgt ccctgatttt tcaccacccc ctgaccgcga atggtgagat tgagaatata     2220

acctttcatt cccagcggtc ggtcgataaa aaaatcgaga taaccgttgg cctcaatcgg     2280

cgttaaaccc gccaccagat gggcattaaa cgagtatccc ggcagcaggg gatcattttg     2340

cgcttcagcc atacttttca tactcccgcc attcagagaa gaaaccaatt gtccatattg     2400

catcagacat tgccgtcact gcgtctttta ctggctcttc tcgctaacca aaccggtaac     2460

cccgcttatt aaaagcattc tgtaacaaag cgggaccaaa gccatgacaa aaacgcgtaa     2520

caaaagtgtc tataatcacg gcagaaaagt ccacattgat tatttgcacg gcgtcacact     2580

ttgctatgcc atagcatttt tatccataag attagcggat cctacctgac gctttttatc     2640

gcaactctct actgtttctc catacccgtt tttttggggt agcgattgaa aacgatgcag     2700

tttaaggttt acacctataa aagagagagc cgttatcgtc tgtttgtgga tgtacagagt     2760

gatattattg acacgcccgg gcgacggatg gtgatccccc tggccagtgc acgtctgctg     2820

tcagataaag tctcccgtga actttacccg gtggtgcata tcggggatga aagctggcgc     2880

atgatgacca ccgatatggc cagtgtgccg gtctccgtta tcggggaaga agtggctgat     2940

ctcagccacc gcgaaaatga catcaaaaac gccattaacc tgatgttttg gggaatataa     3000

tcttctagac atacaatgga agagcagagc cttggtctcn nnnnnnnaag cttgatatcg     3060

aattcctgca gcccggggga tcccatggta cgcgtgctag aggcatcaaa taaaacgaaa     3120

ggctcagtcg aaagactggg cctttcgttt tatctgttgt ttgtcggtga acgctctcct     3180

gagtaggaca aatccgccgc cctagaccta ggcgttcggc tgcggcgagc ggtatcagct     3240

cactcaaagg cggtaatacg gttatccaca gaatcagggg ataacgcagg aaagaacatg     3300

tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc     3360

cataggctcc gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga     3420

aacccgacag gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct     3480

cctgttccga ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg     3540

gcgctttctc aatgctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag     3600

ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat     3660

cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac     3720

aggattagca gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac     3780

tacggctaca ctagaaggac agtatttggt atctgcgctc tgctgaagcc agttaccttc     3840

ggaaaaagag ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggtggtttt     3900

tttgtttgca agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc     3960

ttttctacgg ggtctgacgc tcagtggaac gaaaactcac gttaagggat tttggtcatg     4020

actagtgctt ggattctcac caataaaaaa cgcccggcgg caaccgagcg ttctgaacaa     4080

atccagatgg agttctgagg tcattactgg atctatcaac aggagtccaa gcgagctcga     4140

tatcaaatta cgccccgccc tgccactcat cgcagtactg ttgtaattca ttaagcattc     4200

tgccgacatg gaagccatca cagacggcat gatgaacctg aatcgccagc ggcatcagca     4260

ccttgtcgcc ttgcgtataa tatttgccca tggtgaaaac gggggcgaag aagttgtcca     4320

tattggccac gtttaaatca aaactggtga aactcaccca gggattggct gagacgaaaa     4380

acatattctc aataaaccct ttagggaaat aggccaggtt ttcaccgtaa cacgccacat     4440

cttgcgaata tatgtgtaga aactgccgga aatcgtcgtg gtattcactc cagagcgatg     4500

aaaacgtttc agtttgctca tggaaaacgg tgtaacaagg gtgaacacta tcccatatca     4560

ccagctcacc gtctttcatt gccatacgga attccggatg agcattcatc aggcgggcaa     4620

gaatgtgaat aaaggccgga taaaacttgt gcttattttt ctttacggtc tttaaaaagg     4680

ccgtaatatc cagctgaacg gtctggttat aggtacattg agcaactgac tgaaatgcct     4740

caaaatgttc tttacgatgc cattgggata tatcaacggt ggtatatcca gtgatttttt     4800

tctccatttt agcttcctta gctcctgaaa atctcgataa ctcaaaaaat acgcccggta     4860

gtgatcttat ttcattatgg tgaaagttgg aacctcttac gtgccgatca acgtctcatt     4920

ttcgccagat atcgacgtct aagaaaccat tattatcatg acattaacct ataaaaatag     4980

gcgtatcacg aggccctttc gtcttcacc                                       5009


<210>  1576
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA-tag

<400>  1576

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  1577
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS

<400>  1577

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  1578
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A

<400>  1578

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  1579
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mCherry

<400>  1579

Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
1               5                   10                  15      


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
            20                  25                  30          


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
        35                  40                  45              


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
    50                  55                  60                  


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
65                  70                  75                  80  


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
                85                  90                  95      


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
            100                 105                 110         


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
        115                 120                 125             


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
145                 150                 155                 160 


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
                165                 170                 175     


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
            180                 185                 190         


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
        195                 200                 205             


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
    210                 215                 220                 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235     


<210>  1580
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HA-tag

<400>  1580
tacccatacg atgttccaga ttacgct                                           27


<210>  1581
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NLS

<400>  1581
ccaaaaaaga aaagaaaagt t                                                 21


<210>  1582
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P2A

<400>  1582
gccaccaact tcagcctgct gaagcaggcc ggcgacgtgg aggagaaccc cggcccc          57


<210>  1583
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mCherry

<400>  1583
atggtgagca agggcgagga ggataacatg gccatcatca aggagttcat gcgcttcaag       60

gtgcacatgg agggctccgt gaacggccac gagttcgaga tcgagggcga gggcgagggc      120

cgcccctacg agggcaccca gaccgccaag ctgaaggtga ccaagggtgg ccccctgccc      180

ttcgcctggg acatcctgtc ccctcagttc atgtacggct ccaaggccta cgtgaagcac      240

cccgccgaca tccccgacta cttgaagctg tccttccccg agggcttcaa gtgggagcgc      300

gtgatgaact tcgaggacgg cggcgtggtg accgtgaccc aggactcctc cctgcaggac      360

ggcgagttca tctacaaggt gaagctgcgc ggcaccaact tcccctccga cggccccgta      420

atgcagaaga agaccatggg ctgggaggcc tcctccgagc ggatgtaccc cgaggacggc      480

gccctgaagg gcgagatcaa gcagaggctg aagctgaagg acggcggcca ctacgacgct      540

gaggtcaaga ccacctacaa ggccaagaag cccgtgcagc tgcccggcgc ctacaacgtc      600

aacatcaagt tggacatcac ctcccacaac gaggactaca ccatcgtgga acagtacgaa      660

cgcgccgagg gccgccactc caccggcggc atggacgagc tgtacaagta g               711


