                         SEQUENCE LISTING

<110>  Regeneron Pharmaceuticals, Inc.
       Lotta, Luca Andrea
       Akbari, Parsa
       Sosina, Olukayode
       Ferreira, Manuel Allen Revez
       Baras, Aris
 
<120>  Methods Of Treating Metabolic Disorders With Inhibin Subunit Beta
        E (INHBE) Inhibitors

<130>  189238.05702 (3448) (10854WO01)

<160>  29

<170>  PatentIn version 3.5

<210>  1
<211>  2719
<212>  DNA
<213>  homo sapien

<400>  1
agtagccaga catgagctgt gagggtcaag cacagctatc catcagatga tctactttca       60

gccttcctga gtcccagaca atagaagaca ggtggctgta cccttggcca agggtaggtg      120

tggcagtggt gtctgctgtc actgtgccct cattggcccc cagcaatcag actcaacaga      180

cggagcaact gccatccgag gctcctgaac cagggccatt caccaggagc atgcggctcc      240

ctgatgtcca gctctggctg gtgctgctgt gggcactggt gcgagcacag gggacagggt      300

ctgtgtgtcc ctcctgtggg ggctccaaac tggcacccca agcagaacga gctctggtgc      360

tggagctagc caagcagcaa atcctggatg ggttgcacct gaccagtcgt cccagaataa      420

ctcatcctcc accccaggca gcgctgacca gagccctccg gagactacag ccagggagtg      480

tggctccagg gaatggggag gaggtcatca gctttgctac tgtcacaggt gggtgaggga      540

gagagcaaca ggcaaagagc agacagggaa agggaggcag aaggggagcc tggcaggagc      600

agcagaggga gtggggtgtg gcaggagaag gaggagctgg ggcagggact ggttgcagag      660

gacacaaagc agtctctact tttctagagg taggttcgag ggagagcagt gggcagggct      720

tggggagtct cagaggagag cttcatctct actcacattt tctttccctt ttctgtcttt      780

cgggcagact ccacttcagc ctacagctcc ctgctcactt ttcacctgtc cactcctcgg      840

tcccaccacc tgtaccatgc ccgcctgtgg ctgcacgtgc tccccaccct tcctggcact      900

ctttgcttga ggatcttccg atggggacca aggaggaggc gccaagggtc ccgcactctc      960

ctggctgagc accacatcac caacctgggc tggcatacct taactctgcc ctctagtggc     1020

ttgaggggtg agaagtctgg tgtcctgaaa ctgcaactag actgcagacc cctagaaggc     1080

aacagcacag ttactggaca accgaggcgg ctcttggaca cagcaggaca ccagcagccc     1140

ttcctagagc ttaagatccg agccaatgag cctggagcag gccgggccag gaggaggacc     1200

cccacctgtg agcctgcgac ccccttatgt tgcaggcgag accattacgt agacttccag     1260

gaactgggat ggcgggactg gatactgcag cccgaggggt accagctgaa ttactgcagt     1320

gggcagtgcc ctccccacct ggctggcagc ccaggcattg ctgcctcttt ccattctgcc     1380

gtcttcagcc tcctcaaagc caacaatcct tggcctgcca gtacctcctg ttgtgtccct     1440

actgcccgaa ggcccctctc tctcctctac ctggatcata atggcaatgt ggtcaagacg     1500

gatgtgccag atatggtggt ggaggcctgt ggctgcagct agcaagagga cctggggctt     1560

tggagtgaag agaccaagat gaagtttccc aggcacaggg catctgtgac tggaggcatc     1620

agattcctga tccacacccc aacccaacaa ccacctggca atatgactca cttgacccct     1680

atgggaccca aatgggcact ttcttgtctg agactctggc ttattccagg ttggctgatg     1740

tgttgggaga tgggtaaagc gtttcttcta aaggggtcta cccagaaagc atgatttcct     1800

gccctaagtc ctgtgagaag atgtcaggga ctagggaggg agggagggaa ggcagagaaa     1860

aattacttag cctctcccaa gatgagaaag tcctcaagtg aggggaggag gaagcagata     1920

gatggtccag caggcttgaa gcagggtaag caggctggcc cagggtaagg gctgttgagg     1980

taccttaagg gaaggtcaag agggagatgg gcaaggcgct gagggaggat gcttagggga     2040

cccccagaaa caggagtcag gaaaatgagg cactaagcct aagaagttcc ctggtttttc     2100

ccaggggaca ggacccactg ggagacaagc atttatactt tctttcttct tttttatttt     2160

tttgagatcg agtctcgctc tgtcaccagg ctggagtgca gtgacacgat cttggctcac     2220

tgcaacctcc gtctcctggg ttcaagtgat tcttctgcct cagcctcccg agcagctggg     2280

attacaggcg cccactaatt tttgtattct tagtagaaac gaggtttcaa catgttggcc     2340

aggatggtct caatctcttg acctcttgat ccacccgact tggcctcccg aagtgatgag     2400

attataggcg tgagccaccg cgcctggctt atactttctt aataaaaagg agaaagaaaa     2460

tcaacaaatg tgagtcataa agaagggtta gggtgatggt ccagagcaac agttcttcaa     2520

gtgtactctg taggcttctg ggaggtccct tttcaggggt gtccacaaag tcaaagctat     2580

tttcataata atactaacat gttatttgcc ttttgaattc tcattatctt aaaattgtat     2640

tgtggagttt tccagaggcc gtgtgacatg tgattacatc atctttctga catcattgtt     2700

aatggaatgt gtgcttgta                                                  2719


<210>  2
<211>  1616
<212>  RNA
<213>  homo sapien

<400>  2
augagcugug agggucaagc acagcuaucc aucagaugau cuacuuucag ccuuccugag       60

ucccagacaa uagaagacag guggcuguac ccuuggccaa ggguaggugu ggcaguggug      120

ucugcuguca cugugcccuc auuggccccc agcaaucaga cucaacagac ggagcaacug      180

ccauccgagg cuccugaacc agggccauuc accaggagca ugcggcuccc ugauguccag      240

cucuggcugg ugcugcugug ggcacuggug cgagcacagg ggacaggguc uguguguccc      300

uccugugggg gcuccaaacu ggcaccccaa gcagaacgag cucuggugcu ggagcuagcc      360

aagcagcaaa uccuggaugg guugcaccug accagucguc ccagaauaac ucauccucca      420

ccccaggcag cgcugaccag agcccuccgg agacuacagc cagggagugu ggcuccaggg      480

aauggggagg aggucaucag cuuugcuacu gucacagacu ccacuucagc cuacagcucc      540

cugcucacuu uucaccuguc cacuccucgg ucccaccacc uguaccaugc ccgccugugg      600

cugcacgugc uccccacccu uccuggcacu cuuugcuuga ggaucuuccg auggggacca      660

aggaggaggc gccaaggguc ccgcacucuc cuggcugagc accacaucac caaccugggc      720

uggcauaccu uaacucugcc cucuaguggc uugaggggug agaagucugg uguccugaaa      780

cugcaacuag acugcagacc ccuagaaggc aacagcacag uuacuggaca accgaggcgg      840

cucuuggaca cagcaggaca ccagcagccc uuccuagagc uuaagauccg agccaaugag      900

ccuggagcag gccgggccag gaggaggacc cccaccugug agccugcgac ccccuuaugu      960

ugcaggcgag accauuacgu agacuuccag gaacugggau ggcgggacug gauacugcag     1020

cccgaggggu accagcugaa uuacugcagu gggcagugcc cuccccaccu ggcuggcagc     1080

ccaggcauug cugccucuuu ccauucugcc gucuucagcc uccucaaagc caacaauccu     1140

uggccugcca guaccuccug uugugucccu acugcccgaa ggccccucuc ucuccucuac     1200

cuggaucaua auggcaaugu ggucaagacg gaugugccag auaugguggu ggaggccugu     1260

ggcugcagcu agcaagagga ccuggggcuu uggagugaag agaccaagau gaaguuuccc     1320

aggcacaggg caucugugac uggaggcauc agauuccuga uccacacccc aacccaacaa     1380

ccaccuggca auaugacuca cuugaccccu augggaccca aaugggcacu uucuugucug     1440

agacucuggc uuauuccagg uuggcugaug uguugggaga uggguaaagc guuucuucua     1500

aaggggucua cccagaaagc augauuuccu gcccuaaguc cugugagaag augucaggga     1560

cuagggaggg agggagggaa ggcagagaaa aauuacuuag ccucucccaa gaugag         1616


<210>  3
<211>  2445
<212>  RNA
<213>  homo sapien

<400>  3
agcugugagg gucaagcaca gcuauccauc agaugaucua cuuucagccu uccugagucc       60

cagacaauag aagacaggug gcuguacccu uggccaaggg uagguguggc aguggugucu      120

gcugucacug ugcccucauu ggcccccagc aaucagacuc aacagacgga gcaacugcca      180

uccgaggcuc cugaaccagg gccauucacc aggagcaugc ggcucccuga uguccagcuc      240

uggcuggugc ugcugugggc acuggugcga gcacagggga cagggucugu gugucccucc      300

ugugggggcu ccaaacuggc accccaagca gaacgagcuc uggugcugga gcuagccaag      360

cagcaaaucc uggauggguu gcaccugacc agucguccca gaauaacuca uccuccaccc      420

caggcagcgc ugaccagagc ccuccggaga cuacagccag ggaguguggc uccagggaau      480

ggggaggagg ucaucagcuu ugcuacuguc acagacucca cuucagccua cagcucccug      540

cucacuuuuc accuguccac uccucggucc caccaccugu accaugcccg ccuguggcug      600

cacgugcucc ccacccuucc uggcacucuu ugcuugagga ucuuccgaug gggaccaagg      660

aggaggcgcc aagggucccg cacucuccug gcugagcacc acaucaccaa ccugggcugg      720

cauaccuuaa cucugcccuc uaguggcuug aggggugaga agucuggugu ccugaaacug      780

caacuagacu gcagaccccu agaaggcaac agcacaguua cuggacaacc gaggcggcuc      840

uuggacacag caggacacca gcagcccuuc cuagagcuua agauccgagc caaugagccu      900

ggagcaggcc gggccaggag gaggaccccc accugugagc cugcgacccc cuuauguugc      960

aggcgagacc auuacguaga cuuccaggaa cugggauggc gggacuggau acugcagccc     1020

gagggguacc agcugaauua cugcaguggg cagugcccuc cccaccuggc uggcagccca     1080

ggcauugcug ccucuuucca uucugccguc uucagccucc ucaaagccaa caauccuugg     1140

ccugccagua ccuccuguug ugucccuacu gcccgaaggc cccucucucu ccucuaccug     1200

gaucauaaug gcaauguggu caagacggau gugccagaua ugguggugga ggccuguggc     1260

ugcagcuagc aagaggaccu ggggcuuugg agugaagaga ccaagaugaa guuucccagg     1320

cacagggcau cugugacugg aggcaucaga uuccugaucc acaccccaac ccaacaacca     1380

ccuggcaaua ugacucacuu gaccccuaug ggacccaaau gggcacuuuc uugucugaga     1440

cucuggcuua uuccagguug gcugaugugu ugggagaugg guaaagcguu ucuucuaaag     1500

gggucuaccc agaaagcaug auuuccugcc cuaaguccug ugagaagaug ucagggacua     1560

gggagggagg gagggaaggc agagaaaaau uacuuagccu cucccaagau gagaaagucc     1620

ucaagugagg ggaggaggaa gcagauagau gguccagcag gcuugaagca ggguaagcag     1680

gcuggcccag gguaagggcu guugagguac cuuaagggaa ggucaagagg gagaugggca     1740

aggcgcugag ggaggaugcu uaggggaccc ccagaaacag gagucaggaa aaugaggcac     1800

uaagccuaag aaguucccug guuuuuccca ggggacagga cccacuggga gacaagcauu     1860

uauacuuucu uucuucuuuu uuauuuuuuu gagaucgagu cucgcucugu caccaggcug     1920

gagugcagug acacgaucuu ggcucacugc aaccuccguc uccuggguuc aagugauucu     1980

ucugccucag ccucccgagc agcugggauu acaggcgccc acuaauuuuu guauucuuag     2040

uagaaacgag guuucaacau guuggccagg auggucucaa ucucuugacc ucuugaucca     2100

cccgacuugg ccucccgaag ugaugagauu auaggcguga gccaccgcgc cuggcuuaua     2160

cuuucuuaau aaaaaggaga aagaaaauca acaaauguga gucauaaaga aggguuaggg     2220

ugauggucca gagcaacagu ucuucaagug uacucuguag gcuucuggga ggucccuuuu     2280

cagggguguc cacaaaguca aagcuauuuu cauaauaaua cuaacauguu auuugccuuu     2340

ugaauucuca uuaucuuaaa auuguauugu ggaguuuucc agaggccgug ugacauguga     2400

uuacaucauc uuucugacau cauuguuaaa aaaaaaaaaa aaaaa                     2445


<210>  4
<211>  2459
<212>  RNA
<213>  homo sapien

<400>  4
gggucaagca cagcuaucca ucagaugauc uacuuucagc cuuccugagu cccagacaau       60

agaagacagg uggcuguacc cuuggccaag gguaggugug gcaguggugu cugcugucac      120

ugugcccuca uuggccccca gcaaucagac ucaacagacg gagcaacugc cauccgaggc      180

uccugaacca gggccauuca ccaggagcau gcggcucccu gauguccagc ucuggcuggu      240

gcugcugugg gcacuggugc gagcacaggg gacagggucu gugugucccu ccuguggggg      300

cuccaaacug gcaccccaag cagaacgagc ucuggugcug gagcuagcca agcagcaaau      360

ccuggauggg uugcaccuga ccagucgucc cagaauaacu cauccuccac cccaggcagc      420

gcugaccaga gcccuccgga gacuacagcc agggagugug gcuccaggga auggggagga      480

ggucaucagc uuugcuacug ucacagacuc cacuucagcc uacagcuccc ugcucacuuu      540

ucaccugucc acuccucggu cccaccaccu guaccaugcc cgccuguggc ugcacgugcu      600

ccccacccuu ccuggcacuc uuugcuugag gaucuuccga uggggaccaa ggaggaggcg      660

ccaagggucc cgcacucucc uggcugagca ccacaucacc aaccugggcu ggcauaccuu      720

aacucugccc ucuaguggcu ugagggguga gaagucuggu guccugaaac ugcaacuaga      780

cugcagaccc cuagaaggca acagcacagu uacuggacaa ccgaggcggc ucuuggacac      840

agcaggacac cagcagcccu uccuagagcu uaagauccga gccaaugagc cuggagcagg      900

ccgggccagg aggaggaccc ccaccuguga gccugcgacc cccuuauguu gcaggcgaga      960

ccauuacgua gacuuccagg aacugggaug gcgggacugg auacugcagc ccgaggggua     1020

ccagcugaau uacugcagug ggcagugccc uccccaccug gcuggcagcc caggcauugc     1080

ugccucuuuc cauucugccg ucuucagccu ccucaaagcc aacaauccuu ggccugccag     1140

uaccuccugu ugugucccua cugcccgaag gccccucucu cuccucuacc uggaucauaa     1200

uggcaaugug gucaagacgg augugccaga uaugguggug gaggccugug gcugcagcua     1260

gcaagcagga ccuggggcuu uggagugaag agaccaagau gaaguuuccc aggcacaggg     1320

caucugugac uggaggcauc agauuccuga uccacacccc aacccaacaa ccaccuggca     1380

auaugacuca cuugaccccu augggaccca aaugggcacu uucuugucug agacucuggc     1440

uuauuccagg uuggcugaug uguugggaga uggguaaagc guuucuucua aaggggucua     1500

cucagaaagc augauuuccu gcccuaaguc cugugagaag augucaggga cuagggaggg     1560

agggagggaa ggcagagaaa aauuacuuag ccucucccaa gaugagaaag uccucaagug     1620

aggggaggag gaagcagaua gaugguccag caggcuugaa gcaggguaag caggcuggcc     1680

caggguaagg gcuguugagg uaccuuaagg gaaggucaag agggagaugg gcaaggcgcu     1740

gagggaggau gcuuagggga cccccagaaa caggagucag gaaaaugagg cacuaagccu     1800

aagaaguucc cugguuuuuc ccaggggaca ggacccacug ggcgacaagc auuuauacuu     1860

ucuuucuucu uuuuuauuuu uuugagaucg agucucgcuc ugucaccagg cuggagugca     1920

gugacacgau cuuggcucac ugcaaccucc gucuccuggg uucaagugau ucuucugccu     1980

cagccucccg agcagcuggg auuacaggcg cccacuaauu uuuguauucu uaguagaaac     2040

gagguuucaa cauguuggcc aggauggucu caaucucuug accucuugau ccacccgacu     2100

uggccucccg aagugaugag auuauaggcg ugagccaccg cgccuggcuu auacuuucuu     2160

aauaaaaagg agaaagaaaa ucaacaaaug ugagucauaa agaaggguua gggugauggu     2220

ccagagcaac aguucuucaa guguacucug uaggcuucug ggaggucccu uuucaggggu     2280

guccacaaag ucaaagcuau uuucauaaua auacuaacau guuauuugcc uuuugaauuc     2340

ucauuaucuu aaaauuguau uguggaguuu uccaaaggcc gugugacaug ugauuacauc     2400

aucuuucuga caucaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa      2459


<210>  5
<211>  1616
<212>  DNA
<213>  homo sapien

<400>  5
atgagctgtg agggtcaagc acagctatcc atcagatgat ctactttcag ccttcctgag       60

tcccagacaa tagaagacag gtggctgtac ccttggccaa gggtaggtgt ggcagtggtg      120

tctgctgtca ctgtgccctc attggccccc agcaatcaga ctcaacagac ggagcaactg      180

ccatccgagg ctcctgaacc agggccattc accaggagca tgcggctccc tgatgtccag      240

ctctggctgg tgctgctgtg ggcactggtg cgagcacagg ggacagggtc tgtgtgtccc      300

tcctgtgggg gctccaaact ggcaccccaa gcagaacgag ctctggtgct ggagctagcc      360

aagcagcaaa tcctggatgg gttgcacctg accagtcgtc ccagaataac tcatcctcca      420

ccccaggcag cgctgaccag agccctccgg agactacagc cagggagtgt ggctccaggg      480

aatggggagg aggtcatcag ctttgctact gtcacagact ccacttcagc ctacagctcc      540

ctgctcactt ttcacctgtc cactcctcgg tcccaccacc tgtaccatgc ccgcctgtgg      600

ctgcacgtgc tccccaccct tcctggcact ctttgcttga ggatcttccg atggggacca      660

aggaggaggc gccaagggtc ccgcactctc ctggctgagc accacatcac caacctgggc      720

tggcatacct taactctgcc ctctagtggc ttgaggggtg agaagtctgg tgtcctgaaa      780

ctgcaactag actgcagacc cctagaaggc aacagcacag ttactggaca accgaggcgg      840

ctcttggaca cagcaggaca ccagcagccc ttcctagagc ttaagatccg agccaatgag      900

cctggagcag gccgggccag gaggaggacc cccacctgtg agcctgcgac ccccttatgt      960

tgcaggcgag accattacgt agacttccag gaactgggat ggcgggactg gatactgcag     1020

cccgaggggt accagctgaa ttactgcagt gggcagtgcc ctccccacct ggctggcagc     1080

ccaggcattg ctgcctcttt ccattctgcc gtcttcagcc tcctcaaagc caacaatcct     1140

tggcctgcca gtacctcctg ttgtgtccct actgcccgaa ggcccctctc tctcctctac     1200

ctggatcata atggcaatgt ggtcaagacg gatgtgccag atatggtggt ggaggcctgt     1260

ggctgcagct agcaagagga cctggggctt tggagtgaag agaccaagat gaagtttccc     1320

aggcacaggg catctgtgac tggaggcatc agattcctga tccacacccc aacccaacaa     1380

ccacctggca atatgactca cttgacccct atgggaccca aatgggcact ttcttgtctg     1440

agactctggc ttattccagg ttggctgatg tgttgggaga tgggtaaagc gtttcttcta     1500

aaggggtcta cccagaaagc atgatttcct gccctaagtc ctgtgagaag atgtcaggga     1560

ctagggaggg agggagggaa ggcagagaaa aattacttag cctctcccaa gatgag         1616


<210>  6
<211>  2445
<212>  DNA
<213>  homo sapien

<400>  6
agctgtgagg gtcaagcaca gctatccatc agatgatcta ctttcagcct tcctgagtcc       60

cagacaatag aagacaggtg gctgtaccct tggccaaggg taggtgtggc agtggtgtct      120

gctgtcactg tgccctcatt ggcccccagc aatcagactc aacagacgga gcaactgcca      180

tccgaggctc ctgaaccagg gccattcacc aggagcatgc ggctccctga tgtccagctc      240

tggctggtgc tgctgtgggc actggtgcga gcacagggga cagggtctgt gtgtccctcc      300

tgtgggggct ccaaactggc accccaagca gaacgagctc tggtgctgga gctagccaag      360

cagcaaatcc tggatgggtt gcacctgacc agtcgtccca gaataactca tcctccaccc      420

caggcagcgc tgaccagagc cctccggaga ctacagccag ggagtgtggc tccagggaat      480

ggggaggagg tcatcagctt tgctactgtc acagactcca cttcagccta cagctccctg      540

ctcacttttc acctgtccac tcctcggtcc caccacctgt accatgcccg cctgtggctg      600

cacgtgctcc ccacccttcc tggcactctt tgcttgagga tcttccgatg gggaccaagg      660

aggaggcgcc aagggtcccg cactctcctg gctgagcacc acatcaccaa cctgggctgg      720

cataccttaa ctctgccctc tagtggcttg aggggtgaga agtctggtgt cctgaaactg      780

caactagact gcagacccct agaaggcaac agcacagtta ctggacaacc gaggcggctc      840

ttggacacag caggacacca gcagcccttc ctagagctta agatccgagc caatgagcct      900

ggagcaggcc gggccaggag gaggaccccc acctgtgagc ctgcgacccc cttatgttgc      960

aggcgagacc attacgtaga cttccaggaa ctgggatggc gggactggat actgcagccc     1020

gaggggtacc agctgaatta ctgcagtggg cagtgccctc cccacctggc tggcagccca     1080

ggcattgctg cctctttcca ttctgccgtc ttcagcctcc tcaaagccaa caatccttgg     1140

cctgccagta cctcctgttg tgtccctact gcccgaaggc ccctctctct cctctacctg     1200

gatcataatg gcaatgtggt caagacggat gtgccagata tggtggtgga ggcctgtggc     1260

tgcagctagc aagaggacct ggggctttgg agtgaagaga ccaagatgaa gtttcccagg     1320

cacagggcat ctgtgactgg aggcatcaga ttcctgatcc acaccccaac ccaacaacca     1380

cctggcaata tgactcactt gacccctatg ggacccaaat gggcactttc ttgtctgaga     1440

ctctggctta ttccaggttg gctgatgtgt tgggagatgg gtaaagcgtt tcttctaaag     1500

gggtctaccc agaaagcatg atttcctgcc ctaagtcctg tgagaagatg tcagggacta     1560

gggagggagg gagggaaggc agagaaaaat tacttagcct ctcccaagat gagaaagtcc     1620

tcaagtgagg ggaggaggaa gcagatagat ggtccagcag gcttgaagca gggtaagcag     1680

gctggcccag ggtaagggct gttgaggtac cttaagggaa ggtcaagagg gagatgggca     1740

aggcgctgag ggaggatgct taggggaccc ccagaaacag gagtcaggaa aatgaggcac     1800

taagcctaag aagttccctg gtttttccca ggggacagga cccactggga gacaagcatt     1860

tatactttct ttcttctttt ttattttttt gagatcgagt ctcgctctgt caccaggctg     1920

gagtgcagtg acacgatctt ggctcactgc aacctccgtc tcctgggttc aagtgattct     1980

tctgcctcag cctcccgagc agctgggatt acaggcgccc actaattttt gtattcttag     2040

tagaaacgag gtttcaacat gttggccagg atggtctcaa tctcttgacc tcttgatcca     2100

cccgacttgg cctcccgaag tgatgagatt ataggcgtga gccaccgcgc ctggcttata     2160

ctttcttaat aaaaaggaga aagaaaatca acaaatgtga gtcataaaga agggttaggg     2220

tgatggtcca gagcaacagt tcttcaagtg tactctgtag gcttctggga ggtccctttt     2280

caggggtgtc cacaaagtca aagctatttt cataataata ctaacatgtt atttgccttt     2340

tgaattctca ttatcttaaa attgtattgt ggagttttcc agaggccgtg tgacatgtga     2400

ttacatcatc tttctgacat cattgttaaa aaaaaaaaaa aaaaa                     2445


<210>  7
<211>  2459
<212>  DNA
<213>  homo sapien

<400>  7
gggtcaagca cagctatcca tcagatgatc tactttcagc cttcctgagt cccagacaat       60

agaagacagg tggctgtacc cttggccaag ggtaggtgtg gcagtggtgt ctgctgtcac      120

tgtgccctca ttggccccca gcaatcagac tcaacagacg gagcaactgc catccgaggc      180

tcctgaacca gggccattca ccaggagcat gcggctccct gatgtccagc tctggctggt      240

gctgctgtgg gcactggtgc gagcacaggg gacagggtct gtgtgtccct cctgtggggg      300

ctccaaactg gcaccccaag cagaacgagc tctggtgctg gagctagcca agcagcaaat      360

cctggatggg ttgcacctga ccagtcgtcc cagaataact catcctccac cccaggcagc      420

gctgaccaga gccctccgga gactacagcc agggagtgtg gctccaggga atggggagga      480

ggtcatcagc tttgctactg tcacagactc cacttcagcc tacagctccc tgctcacttt      540

tcacctgtcc actcctcggt cccaccacct gtaccatgcc cgcctgtggc tgcacgtgct      600

ccccaccctt cctggcactc tttgcttgag gatcttccga tggggaccaa ggaggaggcg      660

ccaagggtcc cgcactctcc tggctgagca ccacatcacc aacctgggct ggcatacctt      720

aactctgccc tctagtggct tgaggggtga gaagtctggt gtcctgaaac tgcaactaga      780

ctgcagaccc ctagaaggca acagcacagt tactggacaa ccgaggcggc tcttggacac      840

agcaggacac cagcagccct tcctagagct taagatccga gccaatgagc ctggagcagg      900

ccgggccagg aggaggaccc ccacctgtga gcctgcgacc cccttatgtt gcaggcgaga      960

ccattacgta gacttccagg aactgggatg gcgggactgg atactgcagc ccgaggggta     1020

ccagctgaat tactgcagtg ggcagtgccc tccccacctg gctggcagcc caggcattgc     1080

tgcctctttc cattctgccg tcttcagcct cctcaaagcc aacaatcctt ggcctgccag     1140

tacctcctgt tgtgtcccta ctgcccgaag gcccctctct ctcctctacc tggatcataa     1200

tggcaatgtg gtcaagacgg atgtgccaga tatggtggtg gaggcctgtg gctgcagcta     1260

gcaagcagga cctggggctt tggagtgaag agaccaagat gaagtttccc aggcacaggg     1320

catctgtgac tggaggcatc agattcctga tccacacccc aacccaacaa ccacctggca     1380

atatgactca cttgacccct atgggaccca aatgggcact ttcttgtctg agactctggc     1440

ttattccagg ttggctgatg tgttgggaga tgggtaaagc gtttcttcta aaggggtcta     1500

ctcagaaagc atgatttcct gccctaagtc ctgtgagaag atgtcaggga ctagggaggg     1560

agggagggaa ggcagagaaa aattacttag cctctcccaa gatgagaaag tcctcaagtg     1620

aggggaggag gaagcagata gatggtccag caggcttgaa gcagggtaag caggctggcc     1680

cagggtaagg gctgttgagg taccttaagg gaaggtcaag agggagatgg gcaaggcgct     1740

gagggaggat gcttagggga cccccagaaa caggagtcag gaaaatgagg cactaagcct     1800

aagaagttcc ctggtttttc ccaggggaca ggacccactg ggcgacaagc atttatactt     1860

tctttcttct tttttatttt tttgagatcg agtctcgctc tgtcaccagg ctggagtgca     1920

gtgacacgat cttggctcac tgcaacctcc gtctcctggg ttcaagtgat tcttctgcct     1980

cagcctcccg agcagctggg attacaggcg cccactaatt tttgtattct tagtagaaac     2040

gaggtttcaa catgttggcc aggatggtct caatctcttg acctcttgat ccacccgact     2100

tggcctcccg aagtgatgag attataggcg tgagccaccg cgcctggctt atactttctt     2160

aataaaaagg agaaagaaaa tcaacaaatg tgagtcataa agaagggtta gggtgatggt     2220

ccagagcaac agttcttcaa gtgtactctg taggcttctg ggaggtccct tttcaggggt     2280

gtccacaaag tcaaagctat tttcataata atactaacat gttatttgcc ttttgaattc     2340

tcattatctt aaaattgtat tgtggagttt tccaaaggcc gtgtgacatg tgattacatc     2400

atctttctga catcaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa      2459


<210>  8
<211>  350
<212>  PRT
<213>  homo sapien

<400>  8

Met Arg Leu Pro Asp Val Gln Leu Trp Leu Val Leu Leu Trp Ala Leu 
1               5                   10                  15      


Val Arg Ala Gln Gly Thr Gly Ser Val Cys Pro Ser Cys Gly Gly Ser 
            20                  25                  30          


Lys Leu Ala Pro Gln Ala Glu Arg Ala Leu Val Leu Glu Leu Ala Lys 
        35                  40                  45              


Gln Gln Ile Leu Asp Gly Leu His Leu Thr Ser Arg Pro Arg Ile Thr 
    50                  55                  60                  


His Pro Pro Pro Gln Ala Ala Leu Thr Arg Ala Leu Arg Arg Leu Gln 
65                  70                  75                  80  


Pro Gly Ser Val Ala Pro Gly Asn Gly Glu Glu Val Ile Ser Phe Ala 
                85                  90                  95      


Thr Val Thr Asp Ser Thr Ser Ala Tyr Ser Ser Leu Leu Thr Phe His 
            100                 105                 110         


Leu Ser Thr Pro Arg Ser His His Leu Tyr His Ala Arg Leu Trp Leu 
        115                 120                 125             


His Val Leu Pro Thr Leu Pro Gly Thr Leu Cys Leu Arg Ile Phe Arg 
    130                 135                 140                 


Trp Gly Pro Arg Arg Arg Arg Gln Gly Ser Arg Thr Leu Leu Ala Glu 
145                 150                 155                 160 


His His Ile Thr Asn Leu Gly Trp His Thr Leu Thr Leu Pro Ser Ser 
                165                 170                 175     


Gly Leu Arg Gly Glu Lys Ser Gly Val Leu Lys Leu Gln Leu Asp Cys 
            180                 185                 190         


Arg Pro Leu Glu Gly Asn Ser Thr Val Thr Gly Gln Pro Arg Arg Leu 
        195                 200                 205             


Leu Asp Thr Ala Gly His Gln Gln Pro Phe Leu Glu Leu Lys Ile Arg 
    210                 215                 220                 


Ala Asn Glu Pro Gly Ala Gly Arg Ala Arg Arg Arg Thr Pro Thr Cys 
225                 230                 235                 240 


Glu Pro Ala Thr Pro Leu Cys Cys Arg Arg Asp His Tyr Val Asp Phe 
                245                 250                 255     


Gln Glu Leu Gly Trp Arg Asp Trp Ile Leu Gln Pro Glu Gly Tyr Gln 
            260                 265                 270         


Leu Asn Tyr Cys Ser Gly Gln Cys Pro Pro His Leu Ala Gly Ser Pro 
        275                 280                 285             


Gly Ile Ala Ala Ser Phe His Ser Ala Val Phe Ser Leu Leu Lys Ala 
    290                 295                 300                 


Asn Asn Pro Trp Pro Ala Ser Thr Ser Cys Cys Val Pro Thr Ala Arg 
305                 310                 315                 320 


Arg Pro Leu Ser Leu Leu Tyr Leu Asp His Asn Gly Asn Val Val Lys 
                325                 330                 335     


Thr Asp Val Pro Asp Met Val Val Glu Ala Cys Gly Cys Ser 
            340                 345                 350 


<210>  9
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  gRNA Recognition Sequence

<400>  9
cgtctgttga gtctgattgc                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  gRNA Recognition Sequence

<400>  10
gacggagcaa ctgccatccg                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  gRNA Recognition Sequence

<400>  11
atcagggagc cgcatgctcc                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  gRNA Recognition Sequence

<400>  12
ctgaaccagg gccattcacc                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  gRNA Recognition Sequence

<400>  13
cctggttcag gagcctcgga                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  gRNA Recognition Sequence

<400>  14
catccgaggc tcctgaacca                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  gRNA Recognition Sequence

<400>  15
ccatccgagg ctcctgaacc                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  gRNA Recognition Sequence

<400>  16
gccacctgtc ttctattgtc                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  gRNA Recognition Sequence

<400>  17
agccgcatgc tcctggtgaa                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  gRNA Recognition Sequence

<400>  18
gtctgttgag tctgattgct                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  gRNA Recognition Sequence

<400>  19
aagacaggtg gctgtaccct                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  gRNA Recognition Sequence

<400>  20
ctgattgctg ggggccaatg                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  gRNA Recognition Sequence

<400>  21
tgattgctgg gggccaatga                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  gRNA Recognition Sequence

<400>  22
ccacctgtct tctattgtct                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  gRNA Recognition Sequence

<400>  23
atgctcctgg tgaatggccc                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  gRNA Recognition Sequence

<400>  24
ctgttgagtc tgattgctgg                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  gRNA Recognition Sequence

<400>  25
ctggtgaatg gccctggttc                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  gRNA Recognition Sequence

<400>  26
accactgcca cacctaccct                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  gRNA Recognition Sequence

<400>  27
tctgttgagt ctgattgctg                                                   20


<210>  28
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  original exon 2

<400>  28
agactccact tcagcctaca gct                                               23


<210>  29
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  predicted exon 2

<400>  29
acactccact tcagcctaca gct                                               23


