                         SEQUENCE LISTING

<110>  Istituto Superiore di Sanit
 
<120>  NUCLEOTIDE SEQUENCE EXPRESSING AN EXTRACELLULAR VESICLE-ANCHORING
        PROTEIN FUSED WITH SARS-COV-2 ANTIGENS AND RELATED FUSION 
       PROTEIN FOR USE AS VACCINE

<130>  PCT45367

<150>  IT 102020000030740
<151>  2020-12-14

<160>  98    

<170>  PatentIn version 3.5

<210>  1
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nef G3C-V153L-E177G mutant

<400>  1

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Val Ala Arg Glu Leu His Pro Glu Tyr Phe Lys Asn Cys 
        195                 200                 205     


<210>  2
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated form of Nef G3C-V153L-E177G mutant

<400>  2

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Val Ala Arg Glu Leu His Pro Glu Tyr Phe Lys Asn 
        195                 200                 205 


<210>  3
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated form of Nef G3C-V153L-E177G mutant

<400>  3

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Val Ala Arg Glu Leu His Pro Glu Tyr Phe Lys 
        195                 200                 


<210>  4
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated form of Nef G3C-V153L-E177G mutant

<400>  4

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Val Ala Arg Glu Leu His Pro Glu Tyr Phe 
        195                 200             


<210>  5
<211>  202
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated form of Nef G3C-V153L-E177G mutant

<400>  5

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Val Ala Arg Glu Leu His Pro Glu Tyr 
        195                 200         


<210>  6
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated form of Nef G3C-V153L-E177G mutant

<400>  6

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Val Ala Arg Glu Leu His Pro Glu 
        195                 200     


<210>  7
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated form of Nef G3C-V153L-E177G mutant

<400>  7

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Val Ala Arg Glu Leu His Pro 
        195                 200 


<210>  8
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated form of Nef G3C-V153L-E177G mutant

<400>  8

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Val Ala Arg Glu Leu His 
        195                 


<210>  9
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated form of Nef G3C-V153L-E177G mutant

<400>  9

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Val Ala Arg Glu Leu 
        195             


<210>  10
<211>  197
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated form of Nef G3C-V153L-E177G mutant

<400>  10

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Val Ala Arg Glu 
        195         


<210>  11
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated form of Nef G3C-V153L-E177G mutant

<400>  11

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Val Ala Arg 
        195     


<210>  12
<211>  195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated form of Nef G3C-V153L-E177G mutant

<400>  12

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Val Ala 
        195 


<210>  13
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated form of Nef G3C-V153L-E177G mutant

<400>  13

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Val 
        


<210>  14
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated form of Nef G3C-V153L-E177G mutant

<400>  14

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His 
    


<210>  15
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated form of Nef G3C-V153L-E177G mutant

<400>  15

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


<210>  16
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated form of Nef G3C-V153L-E177G mutant

<400>  16

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe 
            180                 185                 190     


<210>  17
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated form of Nef G3C-V153L-E177G mutant

<400>  17

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala 
            180                 185                 190 


<210>  18
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated form of Nef G3C-V153L-E177G mutant

<400>  18

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu 
            180                 185                 


<210>  19
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated form of Nef G3C-V153L-E177G mutant

<400>  19

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg 
            180                 185             


<210>  20
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated form of Nef G3C-V153L-E177G mutant

<400>  20

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser 
            180                 185         


<210>  21
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated form of Nef G3C-V153L-E177G mutant

<400>  21

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp 
            180                 185     


<210>  22
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated form of Nef G3C-V153L-E177G mutant

<400>  22

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe 
            180                 185 


<210>  23
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated form of Nef G3C-V153L-E177G mutant

<400>  23

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg 
            180                 


<210>  24
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated form of Nef G3C-V153L-E177G mutant

<400>  24

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp 
            180             


<210>  25
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated form of Nef G3C-V153L-E177G mutant

<400>  25

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu 
            180         


<210>  26
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated form of Nef G3C-V153L-E177G mutant

<400>  26

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu 
            180     


<210>  27
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated form of Nef G3C-V153L-E177G mutant

<400>  27

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val 
            180 


<210>  28
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated form of Nef G3C-V153L-E177G mutant

<400>  28

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu 
            


<210>  29
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated form of Nef G3C-V153L-E177G mutant

<400>  29

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg 
        


<210>  30
<211>  177
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated form of Nef G3C-V153L-E177G mutant

<400>  30

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly 
    


<210>  31
<211>  661
<212>  PRT
<213>  SARS-CoV-2

<400>  31

Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly 
1               5                   10                  15      


Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr 
            20                  25                  30          


Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala 
        35                  40                  45              


Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val 
    50                  55                  60                  


Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn 
65                  70                  75                  80  


Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln 
                85                  90                  95      


Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys 
            100                 105                 110         


Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys 
        115                 120                 125             


Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala 
    130                 135                 140                 


Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu 
145                 150                 155                 160 


Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys 
                165                 170                 175     


Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn 
            180                 185                 190         


Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val 
        195                 200                 205             


Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala 
    210                 215                 220                 


Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
225                 230                 235                 240 


Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
                245                 250                 255     


Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
            260                 265                 270         


Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
        275                 280                 285             


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
    290                 295                 300                 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
305                 310                 315                 320 


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
                325                 330                 335     


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
            340                 345                 350         


Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
        355                 360                 365             


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
    370                 375                 380                 


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala 
385                 390                 395                 400 


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
                405                 410                 415     


Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 
            420                 425                 430         


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
        435                 440                 445             


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 
    450                 455                 460                 


Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro 
465                 470                 475                 480 


Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
                485                 490                 495     


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
            500                 505                 510         


Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr 
        515                 520                 525             


Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
    530                 535                 540                 


Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro 
545                 550                 555                 560 


Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
                565                 570                 575     


Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
            580                 585                 590         


Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
        595                 600                 605             


Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
    610                 615                 620                 


Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser 
625                 630                 635                 640 


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
                645                 650                 655     


Thr Gln Thr Asn Ser 
            660     


<210>  32
<211>  365
<212>  PRT
<213>  SARS-CoV-2

<400>  32

Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
1               5                   10                  15      


Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
            20                  25                  30          


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
        35                  40                  45              


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
    50                  55                  60                  


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
65                  70                  75                  80  


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
                85                  90                  95      


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
            100                 105                 110         


Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val 
        115                 120                 125             


Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
    130                 135                 140                 


Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg 
145                 150                 155                 160 


Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln Gln 
                165                 170                 175     


Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn Leu Ala Ala Thr 
            180                 185                 190         


Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg Val Asp Phe Cys 
        195                 200                 205             


Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln Ser Ala Pro His Gly 
    210                 215                 220                 


Val Val Phe Leu His Val Thr Tyr Val Pro Ala Gln Glu Lys Asn Phe 
225                 230                 235                 240 


Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys Ala His Phe Pro Arg 
                245                 250                 255     


Glu Gly Val Phe Val Ser Asn Gly Thr His Trp Phe Val Thr Gln Arg 
            260                 265                 270         


Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr Asp Asn Thr Phe Val Ser 
        275                 280                 285             


Gly Asn Cys Asp Val Val Ile Gly Ile Val Asn Asn Thr Val Tyr Asp 
    290                 295                 300                 


Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu Leu Asp Lys Tyr 
305                 310                 315                 320 


Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu Gly Asp Ile Ser Gly 
                325                 330                 335     


Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp Arg Leu Asn 
            340                 345                 350         


Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu 
        355                 360                 365 


<210>  33
<211>  119
<212>  PRT
<213>  SARS-CoV-2

<400>  33

Ala Arg Thr Arg Ser Met Trp Ser Phe Asn Pro Glu Thr Asn Ile Leu 
1               5                   10                  15      


Leu Asn Val Pro Leu His Gly Thr Ile Leu Thr Arg Pro Leu Leu Glu 
            20                  25                  30          


Ser Glu Leu Val Ile Gly Ala Val Ile Leu Arg Gly His Leu Arg Ile 
        35                  40                  45              


Ala Gly His His Leu Gly Arg Cys Asp Ile Lys Asp Leu Pro Lys Glu 
    50                  55                  60                  


Ile Thr Val Ala Thr Ser Arg Thr Leu Ser Tyr Tyr Lys Leu Gly Ala 
65                  70                  75                  80  


Ser Gln Arg Val Ala Gly Asp Ser Gly Phe Ala Ala Tyr Ser Arg Tyr 
                85                  90                  95      


Arg Ile Gly Asn Tyr Lys Leu Asn Thr Asp His Ser Ser Ser Ser Asp 
            100                 105                 110         


Asn Ile Ala Leu Leu Val Gln 
        115                 


<210>  34
<211>  418
<212>  PRT
<213>  SARS-CoV-2

<400>  34

Ser Asp Asn Gly Pro Gln Asn Gln Arg Asn Ala Pro Arg Ile Thr Phe 
1               5                   10                  15      


Gly Gly Pro Ser Asp Ser Thr Gly Ser Asn Gln Asn Gly Glu Arg Ser 
            20                  25                  30          


Gly Ala Arg Ser Lys Gln Arg Arg Pro Gln Gly Leu Pro Asn Asn Thr 
        35                  40                  45              


Ala Ser Trp Phe Thr Ala Leu Thr Gln His Gly Lys Glu Asp Leu Lys 
    50                  55                  60                  


Phe Pro Arg Gly Gln Gly Val Pro Ile Asn Thr Asn Ser Ser Pro Asp 
65                  70                  75                  80  


Asp Gln Ile Gly Tyr Tyr Arg Arg Ala Thr Arg Arg Ile Arg Gly Gly 
                85                  90                  95      


Asp Gly Lys Met Lys Asp Leu Ser Pro Arg Trp Tyr Phe Tyr Tyr Leu 
            100                 105                 110         


Gly Thr Gly Pro Glu Ala Gly Leu Pro Tyr Gly Ala Asn Lys Asp Gly 
        115                 120                 125             


Ile Ile Trp Val Ala Thr Glu Gly Ala Leu Asn Thr Pro Lys Asp His 
    130                 135                 140                 


Ile Gly Thr Arg Asn Pro Ala Asn Asn Ala Ala Ile Val Leu Gln Leu 
145                 150                 155                 160 


Pro Gln Gly Thr Thr Leu Pro Lys Gly Phe Tyr Ala Glu Gly Ser Arg 
                165                 170                 175     


Gly Gly Ser Gln Ala Ser Ser Arg Ser Ser Ser Arg Ser Arg Asn Ser 
            180                 185                 190         


Ser Arg Asn Ser Thr Pro Gly Ser Ser Arg Gly Thr Ser Pro Ala Arg 
        195                 200                 205             


Met Ala Gly Asn Gly Gly Asp Ala Ala Leu Ala Leu Leu Leu Leu Asp 
    210                 215                 220                 


Arg Leu Asn Gln Leu Glu Ser Lys Met Ser Gly Lys Gly Gln Gln Gln 
225                 230                 235                 240 


Gln Gly Gln Thr Val Thr Lys Lys Ser Ala Ala Glu Ala Ser Lys Lys 
                245                 250                 255     


Pro Arg Gln Lys Arg Thr Ala Thr Lys Ala Tyr Asn Val Thr Gln Ala 
            260                 265                 270         


Phe Gly Arg Arg Gly Pro Glu Gln Thr Gln Gly Asn Phe Gly Asp Gln 
        275                 280                 285             


Glu Leu Ile Arg Gln Gly Thr Asp Tyr Lys His Trp Pro Gln Ile Ala 
    290                 295                 300                 


Gln Phe Ala Pro Ser Ala Ser Ala Phe Phe Gly Met Ser Arg Ile Gly 
305                 310                 315                 320 


Met Glu Val Thr Pro Ser Gly Thr Trp Leu Thr Tyr Thr Gly Ala Ile 
                325                 330                 335     


Lys Leu Asp Asp Lys Asp Pro Asn Phe Lys Asp Gln Val Ile Leu Leu 
            340                 345                 350         


Asn Lys His Ile Asp Ala Tyr Lys Thr Phe Pro Pro Thr Glu Pro Lys 
        355                 360                 365             


Lys Asp Lys Lys Lys Lys Ala Asp Glu Thr Gln Ala Leu Pro Gln Arg 
    370                 375                 380                 


Gln Lys Lys Gln Gln Thr Val Thr Leu Leu Pro Ala Ala Asp Leu Asp 
385                 390                 395                 400 


Asp Phe Ser Lys Gln Leu Gln Gln Ser Met Ser Ser Ala Asp Ser Thr 
                405                 410                 415     


Gln Ala 
        


<210>  35
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  35

Gly Pro Gly Pro 
1               


<210>  36
<211>  879
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein of SEQ ID NO:1,SEQ ID NO:35, SEQ ID NO:31 and SEQ 
       ID NO:87

<400>  36

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Val Ala Arg Glu Leu His Pro Glu Tyr Phe Lys Asn Cys Gly Pro 
        195                 200                 205             


Gly Pro Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr 
    210                 215                 220                 


Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu His 
225                 230                 235                 240 


Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp Phe 
                245                 250                 255     


His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn 
            260                 265                 270         


Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys 
        275                 280                 285             


Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys 
    290                 295                 300                 


Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys 
305                 310                 315                 320 


Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr 
                325                 330                 335     


His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser 
            340                 345                 350         


Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met 
        355                 360                 365             


Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val 
    370                 375                 380                 


Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro 
385                 390                 395                 400 


Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro 
                405                 410                 415     


Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu 
            420                 425                 430         


Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly 
        435                 440                 445             


Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg 
    450                 455                 460                 


Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val 
465                 470                 475                 480 


Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser 
                485                 490                 495     


Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln 
            500                 505                 510         


Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro 
        515                 520                 525             


Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp 
    530                 535                 540                 


Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr 
545                 550                 555                 560 


Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr 
                565                 570                 575     


Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val 
            580                 585                 590         


Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys 
        595                 600                 605             


Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val 
    610                 615                 620                 


Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr 
625                 630                 635                 640 


Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu 
                645                 650                 655     


Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn 
            660                 665                 670         


Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe 
        675                 680                 685             


Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu 
    690                 695                 700                 


Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys 
705                 710                 715                 720 


Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly 
                725                 730                 735     


Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro 
            740                 745                 750         


Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg 
        755                 760                 765             


Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly 
    770                 775                 780                 


Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala 
785                 790                 795                 800 


Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile His 
                805                 810                 815     


Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn 
            820                 825                 830         


Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn 
        835                 840                 845             


Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser 
    850                 855                 860                 


Tyr Gln Thr Gln Thr Asn Ser Asp Tyr Lys Asp Asp Asp Asp Lys 
865                 870                 875                 


<210>  37
<211>  578
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein of SEQ ID NO:1,SEQ ID NO:35, SEQ ID NO:32 and SEQ 
       ID NO:87

<400>  37

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Val Ala Arg Glu Leu His Pro Glu Tyr Phe Lys Asn Cys Gly Pro 
        195                 200                 205             


Gly Pro Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu 
    210                 215                 220                 


Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu 
225                 230                 235                 240 


Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr 
                245                 250                 255     


Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro 
            260                 265                 270         


Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln 
        275                 280                 285             


Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser 
    290                 295                 300                 


Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu 
305                 310                 315                 320 


Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr 
                325                 330                 335     


Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu 
            340                 345                 350         


Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Gln Ile Asp 
        355                 360                 365             


Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln 
    370                 375                 380                 


Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn Leu Ala Ala 
385                 390                 395                 400 


Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg Val Asp Phe 
                405                 410                 415     


Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln Ser Ala Pro His 
            420                 425                 430         


Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ala Gln Glu Lys Asn 
        435                 440                 445             


Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys Ala His Phe Pro 
    450                 455                 460                 


Arg Glu Gly Val Phe Val Ser Asn Gly Thr His Trp Phe Val Thr Gln 
465                 470                 475                 480 


Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr Asp Asn Thr Phe Val 
                485                 490                 495     


Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val Asn Asn Thr Val Tyr 
            500                 505                 510         


Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu Leu Asp Lys 
        515                 520                 525             


Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu Gly Asp Ile Ser 
    530                 535                 540                 


Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp Arg Leu 
545                 550                 555                 560 


Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Asp Tyr Lys Asp Asp Asp 
                565                 570                 575     


Asp Lys 
        


<210>  38
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein of SEQ ID NO:1,SEQ ID NO:35, SEQ ID NO:33 and SEQ 
       ID NO:87

<400>  38

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Val Ala Arg Glu Leu His Pro Glu Tyr Phe Lys Asn Cys Gly Pro 
        195                 200                 205             


Gly Pro Ala Arg Thr Arg Ser Met Trp Ser Phe Asn Pro Glu Thr Asn 
    210                 215                 220                 


Ile Leu Leu Asn Val Pro Leu His Gly Thr Ile Leu Thr Arg Pro Leu 
225                 230                 235                 240 


Leu Glu Ser Glu Leu Val Ile Gly Ala Val Ile Leu Arg Gly His Leu 
                245                 250                 255     


Arg Ile Ala Gly His His Leu Gly Arg Cys Asp Ile Lys Asp Leu Pro 
            260                 265                 270         


Lys Glu Ile Thr Val Ala Thr Ser Arg Thr Leu Ser Tyr Tyr Lys Leu 
        275                 280                 285             


Gly Ala Ser Gln Arg Val Ala Gly Asp Ser Gly Phe Ala Ala Tyr Ser 
    290                 295                 300                 


Arg Tyr Arg Ile Gly Asn Tyr Lys Leu Asn Thr Asp His Ser Ser Ser 
305                 310                 315                 320 


Ser Asp Asn Ile Ala Leu Leu Val Gln Asp Tyr Lys Asp Asp Asp Asp 
                325                 330                 335     


Lys 
    


<210>  39
<211>  636
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein of SEQ ID NO:1,SEQ ID NO:35, SEQ ID NO:34 and SEQ 
       ID NO:87

<400>  39

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Val Ala Arg Glu Leu His Pro Glu Tyr Phe Lys Asn Cys Gly Pro 
        195                 200                 205             


Gly Pro Ser Asp Asn Gly Pro Gln Asn Gln Arg Asn Ala Pro Arg Ile 
    210                 215                 220                 


Thr Phe Gly Gly Pro Ser Asp Ser Thr Gly Ser Asn Gln Asn Gly Glu 
225                 230                 235                 240 


Arg Ser Gly Ala Arg Ser Lys Gln Arg Arg Pro Gln Gly Leu Pro Asn 
                245                 250                 255     


Asn Thr Ala Ser Trp Phe Thr Ala Leu Thr Gln His Gly Lys Glu Asp 
            260                 265                 270         


Leu Lys Phe Pro Arg Gly Gln Gly Val Pro Ile Asn Thr Asn Ser Ser 
        275                 280                 285             


Pro Asp Asp Gln Ile Gly Tyr Tyr Arg Arg Ala Thr Arg Arg Ile Arg 
    290                 295                 300                 


Gly Gly Asp Gly Lys Met Lys Asp Leu Ser Pro Arg Trp Tyr Phe Tyr 
305                 310                 315                 320 


Tyr Leu Gly Thr Gly Pro Glu Ala Gly Leu Pro Tyr Gly Ala Asn Lys 
                325                 330                 335     


Asp Gly Ile Ile Trp Val Ala Thr Glu Gly Ala Leu Asn Thr Pro Lys 
            340                 345                 350         


Asp His Ile Gly Thr Arg Asn Pro Ala Asn Asn Ala Ala Ile Val Leu 
        355                 360                 365             


Gln Leu Pro Gln Gly Thr Thr Leu Pro Lys Gly Phe Tyr Ala Glu Gly 
    370                 375                 380                 


Ser Arg Gly Gly Ser Gln Ala Ser Ser Arg Ser Ser Ser Arg Ser Arg 
385                 390                 395                 400 


Asn Ser Ser Arg Asn Ser Thr Pro Gly Ser Ser Arg Gly Thr Ser Pro 
                405                 410                 415     


Ala Arg Met Ala Gly Asn Gly Gly Asp Ala Ala Leu Ala Leu Leu Leu 
            420                 425                 430         


Leu Asp Arg Leu Asn Gln Leu Glu Ser Lys Met Ser Gly Lys Gly Gln 
        435                 440                 445             


Gln Gln Gln Gly Gln Thr Val Thr Lys Lys Ser Ala Ala Glu Ala Ser 
    450                 455                 460                 


Lys Lys Pro Arg Gln Lys Arg Thr Ala Thr Lys Ala Tyr Asn Val Thr 
465                 470                 475                 480 


Gln Ala Phe Gly Arg Arg Gly Pro Glu Gln Thr Gln Gly Asn Phe Gly 
                485                 490                 495     


Asp Gln Glu Leu Ile Arg Gln Gly Thr Asp Tyr Lys His Trp Pro Gln 
            500                 505                 510         


Ile Ala Gln Phe Ala Pro Ser Ala Ser Ala Phe Phe Gly Met Ser Arg 
        515                 520                 525             


Ile Gly Met Glu Val Thr Pro Ser Gly Thr Trp Leu Thr Tyr Thr Gly 
    530                 535                 540                 


Ala Ile Lys Leu Asp Asp Lys Asp Pro Asn Phe Lys Asp Gln Val Ile 
545                 550                 555                 560 


Leu Leu Asn Lys His Ile Asp Ala Tyr Lys Thr Phe Pro Pro Thr Glu 
                565                 570                 575     


Pro Lys Lys Asp Lys Lys Lys Lys Ala Asp Glu Thr Gln Ala Leu Pro 
            580                 585                 590         


Gln Arg Gln Lys Lys Gln Gln Thr Val Thr Leu Leu Pro Ala Ala Asp 
        595                 600                 605             


Leu Asp Asp Phe Ser Lys Gln Leu Gln Gln Ser Met Ser Ser Ala Asp 
    610                 615                 620                 


Ser Thr Gln Ala Asp Tyr Lys Asp Asp Asp Asp Lys 
625                 630                 635     


<210>  40
<211>  850
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  usion protein of SEQ ID NO:30,SEQ ID NO:35, SEQ ID NO:31 and SEQ 
       ID NO:87

<400>  40

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Gly Pro Gly Pro Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn 
            180                 185                 190         


Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser 
        195                 200                 205             


Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val 
    210                 215                 220                 


Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg 
225                 230                 235                 240 


Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser 
                245                 250                 255     


Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu 
            260                 265                 270         


Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val 
        275                 280                 285             


Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly 
    290                 295                 300                 


Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg 
305                 310                 315                 320 


Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro 
                325                 330                 335     


Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg 
            340                 345                 350         


Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys 
        355                 360                 365             


His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala 
    370                 375                 380                 


Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe 
385                 390                 395                 400 


Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser 
                405                 410                 415     


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
            420                 425                 430         


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
        435                 440                 445             


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
    450                 455                 460                 


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
465                 470                 475                 480 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
                485                 490                 495     


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            500                 505                 510         


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        515                 520                 525             


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    530                 535                 540                 


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
545                 550                 555                 560 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                565                 570                 575     


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            580                 585                 590         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        595                 600                 605             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    610                 615                 620                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
625                 630                 635                 640 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                645                 650                 655     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            660                 665                 670         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        675                 680                 685             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
    690                 695                 700                 


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
705                 710                 715                 720 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
                725                 730                 735     


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
            740                 745                 750         


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
        755                 760                 765             


Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val 
    770                 775                 780                 


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
785                 790                 795                 800 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
                805                 810                 815     


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
            820                 825                 830         


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Asp Tyr Lys Asp Asp Asp 
        835                 840                 845             


Asp Lys 
    850 


<210>  41
<211>  549
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein of SEQ ID NO:30,SEQ ID NO:35, SEQ ID NO:32 and SEQ
       ID NO:87

<400>  41

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Gly Pro Gly Pro Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala 
            180                 185                 190         


Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro 
        195                 200                 205             


Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu 
    210                 215                 220                 


Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu 
225                 230                 235                 240 


Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly 
                245                 250                 255     


Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln 
            260                 265                 270         


Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala 
        275                 280                 285             


Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala 
    290                 295                 300                 


Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser 
305                 310                 315                 320 


Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu 
                325                 330                 335     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            340                 345                 350         


Val Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn 
        355                 360                 365             


Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg 
    370                 375                 380                 


Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln Ser 
385                 390                 395                 400 


Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ala Gln 
                405                 410                 415     


Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys Ala 
            420                 425                 430         


His Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His Trp Phe 
        435                 440                 445             


Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr Asp Asn 
    450                 455                 460                 


Thr Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val Asn Asn 
465                 470                 475                 480 


Thr Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu 
                485                 490                 495     


Leu Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu Gly 
            500                 505                 510         


Asp Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu Ile 
        515                 520                 525             


Asp Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Asp Tyr Lys 
    530                 535                 540                 


Asp Asp Asp Asp Lys 
545                 


<210>  42
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein of SEQ ID NO:30,SEQ ID NO:35, SEQ ID NO:33 and SEQ
       ID NO:87

<400>  42

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Gly Pro Gly Pro Ala Arg Thr Arg Ser Met Trp Ser Phe Asn Pro 
            180                 185                 190         


Glu Thr Asn Ile Leu Leu Asn Val Pro Leu His Gly Thr Ile Leu Thr 
        195                 200                 205             


Arg Pro Leu Leu Glu Ser Glu Leu Val Ile Gly Ala Val Ile Leu Arg 
    210                 215                 220                 


Gly His Leu Arg Ile Ala Gly His His Leu Gly Arg Cys Asp Ile Lys 
225                 230                 235                 240 


Asp Leu Pro Lys Glu Ile Thr Val Ala Thr Ser Arg Thr Leu Ser Tyr 
                245                 250                 255     


Tyr Lys Leu Gly Ala Ser Gln Arg Val Ala Gly Asp Ser Gly Phe Ala 
            260                 265                 270         


Ala Tyr Ser Arg Tyr Arg Ile Gly Asn Tyr Lys Leu Asn Thr Asp His 
        275                 280                 285             


Ser Ser Ser Ser Asp Asn Ile Ala Leu Leu Val Gln Asp Tyr Lys Asp 
    290                 295                 300                 


Asp Asp Asp Lys 
305             


<210>  43
<211>  607
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein of SEQ ID NO:30,SEQ ID NO:35, SEQ ID NO:34 and SEQ
       ID NO:87

<400>  43

Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Gly Pro Gly Pro Ser Asp Asn Gly Pro Gln Asn Gln Arg Asn Ala 
            180                 185                 190         


Pro Arg Ile Thr Phe Gly Gly Pro Ser Asp Ser Thr Gly Ser Asn Gln 
        195                 200                 205             


Asn Gly Glu Arg Ser Gly Ala Arg Ser Lys Gln Arg Arg Pro Gln Gly 
    210                 215                 220                 


Leu Pro Asn Asn Thr Ala Ser Trp Phe Thr Ala Leu Thr Gln His Gly 
225                 230                 235                 240 


Lys Glu Asp Leu Lys Phe Pro Arg Gly Gln Gly Val Pro Ile Asn Thr 
                245                 250                 255     


Asn Ser Ser Pro Asp Asp Gln Ile Gly Tyr Tyr Arg Arg Ala Thr Arg 
            260                 265                 270         


Arg Ile Arg Gly Gly Asp Gly Lys Met Lys Asp Leu Ser Pro Arg Trp 
        275                 280                 285             


Tyr Phe Tyr Tyr Leu Gly Thr Gly Pro Glu Ala Gly Leu Pro Tyr Gly 
    290                 295                 300                 


Ala Asn Lys Asp Gly Ile Ile Trp Val Ala Thr Glu Gly Ala Leu Asn 
305                 310                 315                 320 


Thr Pro Lys Asp His Ile Gly Thr Arg Asn Pro Ala Asn Asn Ala Ala 
                325                 330                 335     


Ile Val Leu Gln Leu Pro Gln Gly Thr Thr Leu Pro Lys Gly Phe Tyr 
            340                 345                 350         


Ala Glu Gly Ser Arg Gly Gly Ser Gln Ala Ser Ser Arg Ser Ser Ser 
        355                 360                 365             


Arg Ser Arg Asn Ser Ser Arg Asn Ser Thr Pro Gly Ser Ser Arg Gly 
    370                 375                 380                 


Thr Ser Pro Ala Arg Met Ala Gly Asn Gly Gly Asp Ala Ala Leu Ala 
385                 390                 395                 400 


Leu Leu Leu Leu Asp Arg Leu Asn Gln Leu Glu Ser Lys Met Ser Gly 
                405                 410                 415     


Lys Gly Gln Gln Gln Gln Gly Gln Thr Val Thr Lys Lys Ser Ala Ala 
            420                 425                 430         


Glu Ala Ser Lys Lys Pro Arg Gln Lys Arg Thr Ala Thr Lys Ala Tyr 
        435                 440                 445             


Asn Val Thr Gln Ala Phe Gly Arg Arg Gly Pro Glu Gln Thr Gln Gly 
    450                 455                 460                 


Asn Phe Gly Asp Gln Glu Leu Ile Arg Gln Gly Thr Asp Tyr Lys His 
465                 470                 475                 480 


Trp Pro Gln Ile Ala Gln Phe Ala Pro Ser Ala Ser Ala Phe Phe Gly 
                485                 490                 495     


Met Ser Arg Ile Gly Met Glu Val Thr Pro Ser Gly Thr Trp Leu Thr 
            500                 505                 510         


Tyr Thr Gly Ala Ile Lys Leu Asp Asp Lys Asp Pro Asn Phe Lys Asp 
        515                 520                 525             


Gln Val Ile Leu Leu Asn Lys His Ile Asp Ala Tyr Lys Thr Phe Pro 
    530                 535                 540                 


Pro Thr Glu Pro Lys Lys Asp Lys Lys Lys Lys Ala Asp Glu Thr Gln 
545                 550                 555                 560 


Ala Leu Pro Gln Arg Gln Lys Lys Gln Gln Thr Val Thr Leu Leu Pro 
                565                 570                 575     


Ala Ala Asp Leu Asp Asp Phe Ser Lys Gln Leu Gln Gln Ser Met Ser 
            580                 585                 590         


Ser Ala Asp Ser Thr Gln Ala Asp Tyr Lys Asp Asp Asp Asp Lys 
        595                 600                 605         


<210>  44
<211>  618
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:1

<400>  44
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgga ggtttgacag ccgcctagca tttcatcacg tggcccgaga gctgcatccg      600

gagtacttca agaactgc                                                    618


<210>  45
<211>  615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:2

<400>  45
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgga ggtttgacag ccgcctagca tttcatcacg tggcccgaga gctgcatccg      600

gagtacttca agaac                                                       615


<210>  46
<211>  612
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:3

<400>  46
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgga ggtttgacag ccgcctagca tttcatcacg tggcccgaga gctgcatccg      600

gagtacttca ag                                                          612


<210>  47
<211>  609
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:4

<400>  47
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgga ggtttgacag ccgcctagca tttcatcacg tggcccgaga gctgcatccg      600

gagtacttc                                                              609


<210>  48
<211>  606
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:5

<400>  48
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgga ggtttgacag ccgcctagca tttcatcacg tggcccgaga gctgcatccg      600

gagtac                                                                 606


<210>  49
<211>  603
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:6

<400>  49
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgga ggtttgacag ccgcctagca tttcatcacg tggcccgaga gctgcatccg      600

gag                                                                    603


<210>  50
<211>  600
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:7

<400>  50
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgga ggtttgacag ccgcctagca tttcatcacg tggcccgaga gctgcatccg      600


<210>  51
<211>  597
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:8

<400>  51
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgga ggtttgacag ccgcctagca tttcatcacg tggcccgaga gctgcat         597


<210>  52
<211>  594
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:9

<400>  52
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgga ggtttgacag ccgcctagca tttcatcacg tggcccgaga gctg            594


<210>  53
<211>  591
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:10

<400>  53
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgga ggtttgacag ccgcctagca tttcatcacg tggcccgaga g               591


<210>  54
<211>  588
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:11

<400>  54
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgga ggtttgacag ccgcctagca tttcatcacg tggcccga                   588


<210>  55
<211>  585
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:12

<400>  55
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgga ggtttgacag ccgcctagca tttcatcacg tggcc                      585


<210>  56
<211>  582
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:13

<400>  56
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgga ggtttgacag ccgcctagca tttcatcacg tg                         582


<210>  57
<211>  579
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:14

<400>  57
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgga ggtttgacag ccgcctagca tttcatcac                             579


<210>  58
<211>  576
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:15

<400>  58
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgga ggtttgacag ccgcctagca tttcat                                576


<210>  59
<211>  573
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:16

<400>  59
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgga ggtttgacag ccgcctagca ttt                                   573


<210>  60
<211>  570
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:17

<400>  60
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgga ggtttgacag ccgcctagca                                       570


<210>  61
<211>  567
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:18

<400>  61
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgga ggtttgacag ccgccta                                          567


<210>  62
<211>  564
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:19

<400>  62
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgga ggtttgacag ccgc                                             564


<210>  63
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:20

<400>  63
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgga ggtttgacag c                                                561


<210>  64
<211>  558
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:21

<400>  64
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgga ggtttgac                                                    558


<210>  65
<211>  555
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:22

<400>  65
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgga ggttt                                                       555


<210>  66
<211>  552
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:23

<400>  66
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgga gg                                                          552


<210>  67
<211>  549
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:24

<400>  67
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgg                                                              549


<210>  68
<211>  546
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:25

<400>  68
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagag                                                                 546


<210>  69
<211>  543
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:26

<400>  69
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

tta                                                                    543


<210>  70
<211>  540
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:27

<400>  70
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540


<210>  71
<211>  537
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:28

<400>  71
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaa         537


<210>  72
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:29

<400>  72
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gaga            534


<210>  73
<211>  531
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:30

<400>  73
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg g               531


<210>  74
<211>  1983
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:31

<400>  74
accagaacac agctgccacc tgcctacacc aatagcttca cccgcggcgt ttactatcct       60

gataaggtgt tcagaagcag cgtcctgcat tctacacagg accttttcct gcctttcttc      120

agcaatgtga cctggttcca cgcaatccac gtgtctggca ccaacggcac caaacggttc      180

gacaaccccg tgctgccttt caacgacggc gtgtacttcg ccagtaccga gaagtctaac      240

atcattagag gctggatctt cggaactacc ctggatagca agacccagtc tctgctgatc      300

gtgaacaacg ccacaaacgt ggtgatcaag gtgtgcgagt tccaattttg caacgacccc      360

ttcctgggcg tgtactacca caagaacaat aaatcctgga tggaaagcga attccgggtg      420

tattctagcg caaacaactg tacattcgag tacgtgtccc agcccttcct gatggacctc      480

gagggcaagc agggcaattt caagaatctc agagagttcg tgttcaagaa catcgacggc      540

tacttcaaaa tctacagcaa gcacacccca atcaacctgg tgagggatct gcctcagggc      600

ttcagcgccc tggaacctct ggtcgacctg cctatcggca tcaacatcac ccggttccag      660

accctgctgg ccctgcacag atcctatctg acccctggcg acagcagctc cggatggaca      720

gccggcgccg ctgcttatta cgtgggctac ctgcagccta gaacctttct gctgaagtac      780

aacgagaacg gcaccatcac tgatgccgtg gactgcgccc tggaccctct gagcgagaca      840

aagtgcaccc tgaaaagctt caccgtggaa aagggcatct accaaaccag caatttcaga      900

gtgcagccaa cagaatctat cgtgcggttc cccaacatca ccaacctgtg tccttttggc      960

gaggtgttca acgccaccag attcgccagc gtgtacgcct ggaatagaaa gagaatcagc     1020

aactgcgtgg ctgactacag cgtgctgtac aatagcgcca gctttagcac cttcaagtgc     1080

tacggagtga gtcctacaaa actgaacgac ttgtgcttca ccaacgtgta cgccgatagc     1140

ttcgtgatca gaggcgatga ggtgagacag atcgcccctg gccagaccgg aaagatcgcc     1200

gattacaact acaagctgcc tgacgacttc accggctgtg tgatcgcctg gaacagcaac     1260

aacctggatt ccaaagtggg cggcaactac aactacctgt acagactgtt tcggaagagc     1320

aacctcaagc ctttcgagag agatattagc acggaaatct accaggccgg atctacacct     1380

tgtaatggcg tggaaggctt taattgctac tttcccctgc agagctacgg ctttcagcca     1440

accaacggcg tgggatatca gccctaccgg gttgttgtcc tgtcttttga gctgctgcac     1500

gcccctgcta cagtgtgtgg ccctaagaag tccacaaacc tggttaagaa caagtgcgtc     1560

aacttcaact tcaacggcct gacaggcaca ggcgtgctga cagagagcaa caagaaattt     1620

ctgccattcc agcagttcgg cagagacatt gccgacacca cagacgccgt gcgggacccc     1680

cagacactgg aaatcctgga catcacgcct tgcagcttcg gaggcgtgtc cgtgatcaca     1740

cctggaacca ataccagcaa ccaggtggct gtgctgtacc aggatgtgaa ctgcacagaa     1800

gtgcccgtgg ccatccacgc tgaccagctg acacccacct ggcgggtgta cagcaccggc     1860

agcaacgtgt ttcaaacaag agccggatgt ctgatcggcg ccgagcacgt caacaacagc     1920

tacgagtgcg atatccccat cggtgctgga atctgcgcct cttaccagac ccaaaccaat     1980

agc                                                                   1983


<210>  75
<211>  1083
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:32

<400>  75
cagtacggcg attgcctggg agatatcgcc gctagagatc tgatctgtgc ccagaaattc       60

aacggcctga ccgtgctgcc tcctctgctg acagacgaga tgatcgccca gtacacatct      120

gccctgctcg ctggcaccat cacaagcggc tggaccttcg gcgccggcgc cgccctgcag      180

attcctttcg ccatgcagat ggcctataga ttcaacggca tcggcgtgac acagaacgtg      240

ctctacgaga accagaagct gatcgccaat cagttcaaca gcgctatcgg caagatccag      300

gacagcctga gcagcaccgc cagcgccctg ggaaagctgc aagacgtggt caaccagaat      360

gcccaggccc tgaacaccct ggtgaagcag ctgagctcta atttcggcgc tatcagctcc      420

gtgctgaacg acatcctgag cagactggac aaggtggaag ctgaagtgca gatcgaccgg      480

ctgatcaccg gtaggcttca gagcctgcag acctacgtga cccagcagct gatcagagcc      540

gccgagatcc gggcctctgc caacctggcc gccacaaaga tgagcgaatg tgtgctgggc      600

cagtctaagc gggtggactt ctgcggcaaa ggctaccacc tgatgtcttt tccacagagc      660

gctcctcatg gagtggtttt cctgcacgtg acctacgtgc ctgctcagga gaaaaatttt      720

accaccgccc cagccatctg ccacgagggc aaggcctact tccccagaga gggcgtgttc      780

gtgtccaacg gcacacactg gttcgtcacc caaagaaact tctatgaacc ccagatcatc      840

acaaccgaca acacatttgt gtccggcaac tgcgacgttg tgatcggaat cgtgaacaac      900

accgtgtacg accccctgca acctgagctg gacagcttca aagaggaact ggataagtac      960

tttaagaatc acaccagtcc tgacgtcgac ctgggagata tcagcggcat caacgcctcc     1020

gtggtgaaca ttcaaaagga aatcgataga ctgaatgagg tggccaagaa cctgaacgag     1080

agc                                                                   1083


<210>  76
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:33

<400>  76
gctagaacca gaagcatgtg gtccttcaac cccgagacaa acatcctgct gaacgtgcca       60

ctgcacggca caatccttac aagacctctg ctggaaagcg agctggtgat tggcgccgtg      120

atcctccgcg gacatctgag aatcgccggc caccacctgg gcagatgcga catcaaggac      180

ctgcctaagg aaatcaccgt ggccaccagc cggaccctgt cttattacaa actgggagcc      240

agccagagag tggctggcga tagcggcttt gccgcctaca gcagataccg gatcggcaac      300

tacaagctga ataccgacca cagcagctcc tctgataaca tcgccctgct ggtccag         357


<210>  77
<211>  1254
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:34

<400>  77
tctgacaacg gcccccagaa tcagagaaac gcccctagaa tcacattcgg cggacctagc       60

gatagcacag gcagcaacca gaatggagaa agatccggcg ctagaagcaa gcagcggaga      120

cctcagggcc tgcctaacaa caccgccagc tggttcaccg ccctcaccca acacggcaag      180

gaagatctga agttcccccg cggccaggga gtgccaatca acaccaacag ctctcctgac      240

gaccagatcg gctactacag acgggccacc agaagaatac ggggcggcga cggcaaaatg      300

aaggacctga gccctagatg gtacttctac tacctgggca ccggcccaga ggccggactg      360

ccctatggcg ctaacaagga cggcattatc tgggtcgcca cagagggagc tctgaacaca      420

cccaaggacc acatcggcac ccggaacccc gctaacaacg ccgccatcgt gctgcagctg      480

ccccagggca cgaccctgcc caaaggcttc tacgccgagg gctcccgggg cggatctcag      540

gccagctccc ggagcagcag cagatctcgg aatagctccc gcaattctac acctggctcc      600

agcagaggca catctcctgc cagaatggcc ggcaacggcg gcgatgccgc tctggccctg      660

ctgcttctgg atagactgaa tcaactggaa agcaagatga gcggaaaagg ccagcagcag      720

caaggacaga ccgtgaccaa gaagagcgcc gccgaagcct ctaagaaacc tcggcagaaa      780

agaaccgcca caaaggccta caacgtgacc caggcctttg gcagaagggg acctgagcag      840

acccagggga actttggcga ccaggagctg atcagacagg gcaccgacta caagcactgg      900

cctcagatcg cccagttcgc ccctagcgcc agcgcgttct tcggcatgag ccggatcggc      960

atggaagtga caccttctgg cacctggctg acctacaccg gcgccatcaa gctggacgat     1020

aaggacccca acttcaagga tcaagtgatc ctgctgaaca agcatatcga cgcctataag     1080

acctttccac ctaccgagcc taagaaggat aagaagaaga aagccgacga gacacaggcc     1140

ctgcctcaaa gacagaagaa acagcagacc gtgaccctgc tgccagccgc tgacctggac     1200

gacttcagca agcagctgca acagagcatg tccagcgctg atagcacaca ggct           1254


<210>  78
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:35

<400>  78
ggacctgggc cc                                                           12


<210>  79
<211>  2643
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:36

<400>  79
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgga ggtttgacag ccgcctagca tttcatcacg tggcccgaga gctgcatccg      600

gagtacttca agaactgcgg acctgggccc accagaacac agctgccacc tgcctacacc      660

aatagcttca cccgcggcgt ttactatcct gataaggtgt tcagaagcag cgtcctgcat      720

tctacacagg accttttcct gcctttcttc agcaatgtga cctggttcca cgcaatccac      780

gtgtctggca ccaacggcac caaacggttc gacaaccccg tgctgccttt caacgacggc      840

gtgtacttcg ccagtaccga gaagtctaac atcattagag gctggatctt cggaactacc      900

ctggatagca agacccagtc tctgctgatc gtgaacaacg ccacaaacgt ggtgatcaag      960

gtgtgcgagt tccaattttg caacgacccc ttcctgggcg tgtactacca caagaacaat     1020

aaatcctgga tggaaagcga attccgggtg tattctagcg caaacaactg tacattcgag     1080

tacgtgtccc agcccttcct gatggacctc gagggcaagc agggcaattt caagaatctc     1140

agagagttcg tgttcaagaa catcgacggc tacttcaaaa tctacagcaa gcacacccca     1200

atcaacctgg tgagggatct gcctcagggc ttcagcgccc tggaacctct ggtcgacctg     1260

cctatcggca tcaacatcac ccggttccag accctgctgg ccctgcacag atcctatctg     1320

acccctggcg acagcagctc cggatggaca gccggcgccg ctgcttatta cgtgggctac     1380

ctgcagccta gaacctttct gctgaagtac aacgagaacg gcaccatcac tgatgccgtg     1440

gactgcgccc tggaccctct gagcgagaca aagtgcaccc tgaaaagctt caccgtggaa     1500

aagggcatct accaaaccag caatttcaga gtgcagccaa cagaatctat cgtgcggttc     1560

cccaacatca ccaacctgtg tccttttggc gaggtgttca acgccaccag attcgccagc     1620

gtgtacgcct ggaatagaaa gagaatcagc aactgcgtgg ctgactacag cgtgctgtac     1680

aatagcgcca gctttagcac cttcaagtgc tacggagtga gtcctacaaa actgaacgac     1740

ttgtgcttca ccaacgtgta cgccgatagc ttcgtgatca gaggcgatga ggtgagacag     1800

atcgcccctg gccagaccgg aaagatcgcc gattacaact acaagctgcc tgacgacttc     1860

accggctgtg tgatcgcctg gaacagcaac aacctggatt ccaaagtggg cggcaactac     1920

aactacctgt acagactgtt tcggaagagc aacctcaagc ctttcgagag agatattagc     1980

acggaaatct accaggccgg atctacacct tgtaatggcg tggaaggctt taattgctac     2040

tttcccctgc agagctacgg ctttcagcca accaacggcg tgggatatca gccctaccgg     2100

gttgttgtcc tgtcttttga gctgctgcac gcccctgcta cagtgtgtgg ccctaagaag     2160

tccacaaacc tggttaagaa caagtgcgtc aacttcaact tcaacggcct gacaggcaca     2220

ggcgtgctga cagagagcaa caagaaattt ctgccattcc agcagttcgg cagagacatt     2280

gccgacacca cagacgccgt gcgggacccc cagacactgg aaatcctgga catcacgcct     2340

tgcagcttcg gaggcgtgtc cgtgatcaca cctggaacca ataccagcaa ccaggtggct     2400

gtgctgtacc aggatgtgaa ctgcacagaa gtgcccgtgg ccatccacgc tgaccagctg     2460

acacccacct ggcgggtgta cagcaccggc agcaacgtgt ttcaaacaag agccggatgt     2520

ctgatcggcg ccgagcacgt caacaacagc tacgagtgcg atatccccat cggtgctgga     2580

atctgcgcct cttaccagac ccaaaccaat agcgactaca aggacgacga cgacaagtaa     2640

tag                                                                   2643


<210>  80
<211>  1743
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:37

<400>  80
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgga ggtttgacag ccgcctagca tttcatcacg tggcccgaga gctgcatccg      600

gagtacttca agaactgcgg acctgggccc cagtacggcg attgcctggg agatatcgcc      660

gctagagatc tgatctgtgc ccagaaattc aacggcctga ccgtgctgcc tcctctgctg      720

acagacgaga tgatcgccca gtacacatct gccctgctcg ctggcaccat cacaagcggc      780

tggaccttcg gcgccggcgc cgccctgcag attcctttcg ccatgcagat ggcctataga      840

ttcaacggca tcggcgtgac acagaacgtg ctctacgaga accagaagct gatcgccaat      900

cagttcaaca gcgctatcgg caagatccag gacagcctga gcagcaccgc cagcgccctg      960

ggaaagctgc aagacgtggt caaccagaat gcccaggccc tgaacaccct ggtgaagcag     1020

ctgagctcta atttcggcgc tatcagctcc gtgctgaacg acatcctgag cagactggac     1080

aaggtggaag ctgaagtgca gatcgaccgg ctgatcaccg gtaggcttca gagcctgcag     1140

acctacgtga cccagcagct gatcagagcc gccgagatcc gggcctctgc caacctggcc     1200

gccacaaaga tgagcgaatg tgtgctgggc cagtctaagc gggtggactt ctgcggcaaa     1260

ggctaccacc tgatgtcttt tccacagagc gctcctcatg gagtggtttt cctgcacgtg     1320

acctacgtgc ctgctcagga gaaaaatttt accaccgccc cagccatctg ccacgagggc     1380

aaggcctact tccccagaga gggcgtgttc gtgtccaacg gcacacactg gttcgtcacc     1440

caaagaaact tctatgaacc ccagatcatc acaaccgaca acacatttgt gtccggcaac     1500

tgcgacgttg tgatcggaat cgtgaacaac accgtgtacg accccctgca acctgagctg     1560

gacagcttca aagaggaact ggataagtac tttaagaatc acaccagtcc tgacgtcgac     1620

ctgggagata tcagcggcat caacgcctcc gtggtgaaca ttcaaaagga aatcgataga     1680

ctgaatgagg tggccaagaa cctgaacgag agcgactaca aggacgacga cgacaagtaa     1740

tag                                                                   1743


<210>  81
<211>  1017
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:38

<400>  81
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgga ggtttgacag ccgcctagca tttcatcacg tggcccgaga gctgcatccg      600

gagtacttca agaactgcgg acctgggccc gctagaacca gaagcatgtg gtccttcaac      660

cccgagacaa acatcctgct gaacgtgcca ctgcacggca caatccttac aagacctctg      720

ctggaaagcg agctggtgat tggcgccgtg atcctccgcg gacatctgag aatcgccggc      780

caccacctgg gcagatgcga catcaaggac ctgcctaagg aaatcaccgt ggccaccagc      840

cggaccctgt cttattacaa actgggagcc agccagagag tggctggcga tagcggcttt      900

gccgcctaca gcagataccg gatcggcaac tacaagctga ataccgacca cagcagctcc      960

tctgataaca tcgccctgct ggtccaggac tacaaggacg acgacgacaa gtaatag        1017


<210>  82
<211>  1914
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:39

<400>  82
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgga ggtttgacag ccgcctagca tttcatcacg tggcccgaga gctgcatccg      600

gagtacttca agaactgcgg acctgggccc tctgacaacg gcccccagaa tcagagaaac      660

gcccctagaa tcacattcgg cggacctagc gatagcacag gcagcaacca gaatggagaa      720

agatccggcg ctagaagcaa gcagcggaga cctcagggcc tgcctaacaa caccgccagc      780

tggttcaccg ccctcaccca acacggcaag gaagatctga agttcccccg cggccaggga      840

gtgccaatca acaccaacag ctctcctgac gaccagatcg gctactacag acgggccacc      900

agaagaatac ggggcggcga cggcaaaatg aaggacctga gccctagatg gtacttctac      960

tacctgggca ccggcccaga ggccggactg ccctatggcg ctaacaagga cggcattatc     1020

tgggtcgcca cagagggagc tctgaacaca cccaaggacc acatcggcac ccggaacccc     1080

gctaacaacg ccgccatcgt gctgcagctg ccccagggca cgaccctgcc caaaggcttc     1140

tacgccgagg gctcccgggg cggatctcag gccagctccc ggagcagcag cagatctcgg     1200

aatagctccc gcaattctac acctggctcc agcagaggca catctcctgc cagaatggcc     1260

ggcaacggcg gcgatgccgc tctggccctg ctgcttctgg atagactgaa tcaactggaa     1320

agcaagatga gcggaaaagg ccagcagcag caaggacaga ccgtgaccaa gaagagcgcc     1380

gccgaagcct ctaagaaacc tcggcagaaa agaaccgcca caaaggccta caacgtgacc     1440

caggcctttg gcagaagggg acctgagcag acccagggga actttggcga ccaggagctg     1500

atcagacagg gcaccgacta caagcactgg cctcagatcg cccagttcgc ccctagcgcc     1560

agcgcgttct tcggcatgag ccggatcggc atggaagtga caccttctgg cacctggctg     1620

acctacaccg gcgccatcaa gctggacgat aaggacccca acttcaagga tcaagtgatc     1680

ctgctgaaca agcatatcga cgcctataag acctttccac ctaccgagcc taagaaggat     1740

aagaagaaga aagccgacga gacacaggcc ctgcctcaaa gacagaagaa acagcagacc     1800

gtgaccctgc tgccagccgc tgacctggac gacttcagca agcagctgca acagagcatg     1860

tccagcgctg atagcacaca ggctgactac aaggacgacg acgacaagta atag           1914


<210>  83
<211>  2556
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:40

<400>  83
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gggacctggg      540

cccaccagaa cacagctgcc acctgcctac accaatagct tcacccgcgg cgtttactat      600

cctgataagg tgttcagaag cagcgtcctg cattctacac aggacctttt cctgcctttc      660

ttcagcaatg tgacctggtt ccacgcaatc cacgtgtctg gcaccaacgg caccaaacgg      720

ttcgacaacc ccgtgctgcc tttcaacgac ggcgtgtact tcgccagtac cgagaagtct      780

aacatcatta gaggctggat cttcggaact accctggata gcaagaccca gtctctgctg      840

atcgtgaaca acgccacaaa cgtggtgatc aaggtgtgcg agttccaatt ttgcaacgac      900

cccttcctgg gcgtgtacta ccacaagaac aataaatcct ggatggaaag cgaattccgg      960

gtgtattcta gcgcaaacaa ctgtacattc gagtacgtgt cccagccctt cctgatggac     1020

ctcgagggca agcagggcaa tttcaagaat ctcagagagt tcgtgttcaa gaacatcgac     1080

ggctacttca aaatctacag caagcacacc ccaatcaacc tggtgaggga tctgcctcag     1140

ggcttcagcg ccctggaacc tctggtcgac ctgcctatcg gcatcaacat cacccggttc     1200

cagaccctgc tggccctgca cagatcctat ctgacccctg gcgacagcag ctccggatgg     1260

acagccggcg ccgctgctta ttacgtgggc tacctgcagc ctagaacctt tctgctgaag     1320

tacaacgaga acggcaccat cactgatgcc gtggactgcg ccctggaccc tctgagcgag     1380

acaaagtgca ccctgaaaag cttcaccgtg gaaaagggca tctaccaaac cagcaatttc     1440

agagtgcagc caacagaatc tatcgtgcgg ttccccaaca tcaccaacct gtgtcctttt     1500

ggcgaggtgt tcaacgccac cagattcgcc agcgtgtacg cctggaatag aaagagaatc     1560

agcaactgcg tggctgacta cagcgtgctg tacaatagcg ccagctttag caccttcaag     1620

tgctacggag tgagtcctac aaaactgaac gacttgtgct tcaccaacgt gtacgccgat     1680

agcttcgtga tcagaggcga tgaggtgaga cagatcgccc ctggccagac cggaaagatc     1740

gccgattaca actacaagct gcctgacgac ttcaccggct gtgtgatcgc ctggaacagc     1800

aacaacctgg attccaaagt gggcggcaac tacaactacc tgtacagact gtttcggaag     1860

agcaacctca agcctttcga gagagatatt agcacggaaa tctaccaggc cggatctaca     1920

ccttgtaatg gcgtggaagg ctttaattgc tactttcccc tgcagagcta cggctttcag     1980

ccaaccaacg gcgtgggata tcagccctac cgggttgttg tcctgtcttt tgagctgctg     2040

cacgcccctg ctacagtgtg tggccctaag aagtccacaa acctggttaa gaacaagtgc     2100

gtcaacttca acttcaacgg cctgacaggc acaggcgtgc tgacagagag caacaagaaa     2160

tttctgccat tccagcagtt cggcagagac attgccgaca ccacagacgc cgtgcgggac     2220

ccccagacac tggaaatcct ggacatcacg ccttgcagct tcggaggcgt gtccgtgatc     2280

acacctggaa ccaataccag caaccaggtg gctgtgctgt accaggatgt gaactgcaca     2340

gaagtgcccg tggccatcca cgctgaccag ctgacaccca cctggcgggt gtacagcacc     2400

ggcagcaacg tgtttcaaac aagagccgga tgtctgatcg gcgccgagca cgtcaacaac     2460

agctacgagt gcgatatccc catcggtgct ggaatctgcg cctcttacca gacccaaacc     2520

aatagcgact acaaggacga cgacgacaag taatag                               2556


<210>  84
<211>  1656
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:41

<400>  84
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gggacctggg      540

ccccagtacg gcgattgcct gggagatatc gccgctagag atctgatctg tgcccagaaa      600

ttcaacggcc tgaccgtgct gcctcctctg ctgacagacg agatgatcgc ccagtacaca      660

tctgccctgc tcgctggcac catcacaagc ggctggacct tcggcgccgg cgccgccctg      720

cagattcctt tcgccatgca gatggcctat agattcaacg gcatcggcgt gacacagaac      780

gtgctctacg agaaccagaa gctgatcgcc aatcagttca acagcgctat cggcaagatc      840

caggacagcc tgagcagcac cgccagcgcc ctgggaaagc tgcaagacgt ggtcaaccag      900

aatgcccagg ccctgaacac cctggtgaag cagctgagct ctaatttcgg cgctatcagc      960

tccgtgctga acgacatcct gagcagactg gacaaggtgg aagctgaagt gcagatcgac     1020

cggctgatca ccggtaggct tcagagcctg cagacctacg tgacccagca gctgatcaga     1080

gccgccgaga tccgggcctc tgccaacctg gccgccacaa agatgagcga atgtgtgctg     1140

ggccagtcta agcgggtgga cttctgcggc aaaggctacc acctgatgtc ttttccacag     1200

agcgctcctc atggagtggt tttcctgcac gtgacctacg tgcctgctca ggagaaaaat     1260

tttaccaccg ccccagccat ctgccacgag ggcaaggcct acttccccag agagggcgtg     1320

ttcgtgtcca acggcacaca ctggttcgtc acccaaagaa acttctatga accccagatc     1380

atcacaaccg acaacacatt tgtgtccggc aactgcgacg ttgtgatcgg aatcgtgaac     1440

aacaccgtgt acgaccccct gcaacctgag ctggacagct tcaaagagga actggataag     1500

tactttaaga atcacaccag tcctgacgtc gacctgggag atatcagcgg catcaacgcc     1560

tccgtggtga acattcaaaa ggaaatcgat agactgaatg aggtggccaa gaacctgaac     1620

gagagcgact acaaggacga cgacgacaag taatag                               1656


<210>  85
<211>  930
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:42

<400>  85
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gggacctggg      540

cccgctagaa ccagaagcat gtggtccttc aaccccgaga caaacatcct gctgaacgtg      600

ccactgcacg gcacaatcct tacaagacct ctgctggaaa gcgagctggt gattggcgcc      660

gtgatcctcc gcggacatct gagaatcgcc ggccaccacc tgggcagatg cgacatcaag      720

gacctgccta aggaaatcac cgtggccacc agccggaccc tgtcttatta caaactggga      780

gccagccaga gagtggctgg cgatagcggc tttgccgcct acagcagata ccggatcggc      840

aactacaagc tgaataccga ccacagcagc tcctctgata acatcgccct gctggtccag      900

gactacaagg acgacgacga caagtaatag                                       930


<210>  86
<211>  1827
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:43

<400>  86
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gggacctggg      540

ccctctgaca acggccccca gaatcagaga aacgccccta gaatcacatt cggcggacct      600

agcgatagca caggcagcaa ccagaatgga gaaagatccg gcgctagaag caagcagcgg      660

agacctcagg gcctgcctaa caacaccgcc agctggttca ccgccctcac ccaacacggc      720

aaggaagatc tgaagttccc ccgcggccag ggagtgccaa tcaacaccaa cagctctcct      780

gacgaccaga tcggctacta cagacgggcc accagaagaa tacggggcgg cgacggcaaa      840

atgaaggacc tgagccctag atggtacttc tactacctgg gcaccggccc agaggccgga      900

ctgccctatg gcgctaacaa ggacggcatt atctgggtcg ccacagaggg agctctgaac      960

acacccaagg accacatcgg cacccggaac cccgctaaca acgccgccat cgtgctgcag     1020

ctgccccagg gcacgaccct gcccaaaggc ttctacgccg agggctcccg gggcggatct     1080

caggccagct cccggagcag cagcagatct cggaatagct cccgcaattc tacacctggc     1140

tccagcagag gcacatctcc tgccagaatg gccggcaacg gcggcgatgc cgctctggcc     1200

ctgctgcttc tggatagact gaatcaactg gaaagcaaga tgagcggaaa aggccagcag     1260

cagcaaggac agaccgtgac caagaagagc gccgccgaag cctctaagaa acctcggcag     1320

aaaagaaccg ccacaaaggc ctacaacgtg acccaggcct ttggcagaag gggacctgag     1380

cagacccagg ggaactttgg cgaccaggag ctgatcagac agggcaccga ctacaagcac     1440

tggcctcaga tcgcccagtt cgcccctagc gccagcgcgt tcttcggcat gagccggatc     1500

ggcatggaag tgacaccttc tggcacctgg ctgacctaca ccggcgccat caagctggac     1560

gataaggacc ccaacttcaa ggatcaagtg atcctgctga acaagcatat cgacgcctat     1620

aagacctttc cacctaccga gcctaagaag gataagaaga agaaagccga cgagacacag     1680

gccctgcctc aaagacagaa gaaacagcag accgtgaccc tgctgccagc cgctgacctg     1740

gacgacttca gcaagcagct gcaacagagc atgtccagcg ctgatagcac acaggctgac     1800

tacaaggacg acgacgacaa gtaatag                                         1827


<210>  87
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flag-tag

<400>  87

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  88
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding SEQ ID NO:87

<400>  88
gactacaagg acgacgacga caag                                              24


<210>  89
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8-specific peptide

<400>  89

Asp Leu Tyr Cys Tyr Glu Gln Leu 
1               5               


<210>  90
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8-specific peptide

<400>  90

Arg Ala His Tyr Asn Ile Val Thr Phe 
1               5                   


<210>  91
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8-specific peptide

<400>  91

Leu Cys Val Gln Ser Thr His Val Asp 
1               5                   


<210>  92
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8-specific peptide

<400>  92

Val Asn Phe Asn Phe Asn Gly Leu 
1               5               


<210>  93
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8-specific peptide

<400>  93

Pro Ala Ile Cys His Asp Gly Lys Ala His 
1               5                   10  


<210>  94
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8-specific peptide

<400>  94

Arg Thr Leu Ser Tyr Tyr Lys Leu 
1               5               


<210>  95
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8-specific peptide

<400>  95

Ala Leu Ala Leu Leu Leu Leu Asp Arg Leu 
1               5                   10  


<210>  96
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  furin-like cleavage site

<400>  96

Pro Arg Arg Ala Arg Ser 
1               5       


<210>  97
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EliSpot analysis sequence

<400>  97

Arg Thr Leu Ser Tyr Tyr Lys Leu 
1               5               


<210>  98
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EliSpot analysis sequence

<400>  98

Ala Leu Ala Leu Leu Leu Leu Asp Arg Leu 
1               5                   10  


