                         SEQUENCE LISTING

<110>  MIGAL GALILEE RESEARCH INSTITUTE LTD.
       AFRIAT-JURNOU, Livnat
       PRUSKY, Dov
 
<120>  LACTONASE AND STABILIZED MUTANTS THEREOF FOR TREATING FUNGAL 
       INFECTIONS IN PLANTS

<130>  GAVISH-139 PCT

<150>  63/126,277
<151>  2020-12-16

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  330
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  1

Met Ile Ser Glu Phe Pro Glu Leu Asn Thr Ala Arg Gly Pro Ile Asp 
1               5                   10                  15      


Thr Ala Asp Leu Gly Val Thr Leu Met His Glu His Val Phe Ile Met 
            20                  25                  30          


Thr Thr Glu Ile Ala Gln Asn Tyr Pro Glu Ala Trp Gly Asp Glu Asp 
        35                  40                  45              


Lys Arg Val Ala Gly Ala Ile Ala Arg Leu Gly Glu Leu Lys Ala Arg 
    50                  55                  60                  


Gly Val Asp Thr Ile Val Asp Leu Thr Val Ile Gly Leu Gly Arg Tyr 
65                  70                  75                  80  


Ile Pro Arg Ile Ala Arg Val Ala Ala Ala Thr Glu Leu Asn Ile Val 
                85                  90                  95      


Val Ala Thr Gly Leu Tyr Thr Tyr Asn Asp Val Pro Phe Tyr Phe His 
            100                 105                 110         


Tyr Leu Gly Pro Gly Ala Gln Leu Asp Gly Pro Glu Ile Met Thr Asp 
        115                 120                 125             


Met Phe Val Arg Asp Ile Glu His Gly Ile Ala Asp Thr Gly Ile Lys 
    130                 135                 140                 


Ala Gly Ile Leu Lys Cys Ala Thr Asp Glu Pro Gly Leu Thr Pro Gly 
145                 150                 155                 160 


Val Glu Arg Val Leu Arg Ala Val Ala Gln Ala His Lys Arg Thr Gly 
                165                 170                 175     


Ala Pro Ile Ser Thr His Thr His Ala Gly Leu Arg Arg Gly Leu Asp 
            180                 185                 190         


Gln Gln Arg Ile Phe Ala Glu Glu Gly Val Asp Leu Ser Arg Val Val 
        195                 200                 205             


Ile Gly His Cys Gly Asp Ser Thr Asp Val Gly Tyr Leu Glu Glu Leu 
    210                 215                 220                 


Ile Ala Ala Gly Ser Tyr Leu Gly Met Asp Arg Phe Gly Val Asp Val 
225                 230                 235                 240 


Ile Ser Pro Phe Gln Asp Arg Val Asn Ile Val Ala Arg Met Cys Glu 
                245                 250                 255     


Arg Gly His Ala Asp Lys Met Val Leu Ser His Asp Ala Cys Cys Tyr 
            260                 265                 270         


Phe Asp Ala Leu Pro Glu Glu Leu Val Pro Val Ala Met Pro Asn Trp 
        275                 280                 285             


His Tyr Leu His Ile His Asn Asp Val Ile Pro Ala Leu Lys Gln His 
    290                 295                 300                 


Gly Val Thr Asp Glu Gln Leu His Thr Met Leu Val Asp Asn Pro Arg 
305                 310                 315                 320 


Arg Ile Phe Glu Arg Gln Gly Gly Tyr Gln 
                325                 330 


<210>  2
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  2

Met Ile Ser Glu Phe Pro Glu Leu Asn Thr Ala Arg Gly Pro Ile Asp 
1               5                   10                  15      


Thr Ala Asp Leu Gly Val Thr Leu Met His Glu His Val Phe Ile Met 
            20                  25                  30          


Thr Thr Glu Ile Ala Gln Asn Tyr Pro Glu Ala Trp Gly Asp Glu Asp 
        35                  40                  45              


Lys Arg Val Ala Gly Ala Ile Ala Arg Leu Val Glu Leu Lys Ala Arg 
    50                  55                  60                  


Gly Val Asp Thr Ile Val Asp Leu Thr Val Ile Gly Leu Gly Arg Tyr 
65                  70                  75                  80  


Ile Pro Arg Ile Ala Arg Val Ala Ala Ala Thr Glu Leu Asn Ile Val 
                85                  90                  95      


Val Ala Thr Gly Leu Tyr Thr Tyr Asn Asp Val Pro Phe Tyr Phe His 
            100                 105                 110         


Tyr Leu Gly Pro Gly Ala Gln Leu Asp Gly Pro Glu Ile Met Thr Asp 
        115                 120                 125             


Met Phe Val Arg Asp Ile Glu His Gly Ile Ala Asp Thr Gly Ile Lys 
    130                 135                 140                 


Ala Gly Ile Leu Lys Cys Ala Thr Asp Glu Pro Gly Leu Thr Pro Gly 
145                 150                 155                 160 


Val Glu Arg Val Leu Arg Ala Val Ala Gln Ala His Lys Arg Thr Gly 
                165                 170                 175     


Ala Pro Ile Ser Thr His Thr His Ala Gly Leu Arg Arg Gly Leu Asp 
            180                 185                 190         


Gln Gln Arg Ile Phe Ala Glu Glu Gly Val Asp Leu Ser Arg Val Val 
        195                 200                 205             


Ile Gly His Cys Gly Asp Ser Thr Asp Val Gly Tyr Leu Glu Glu Leu 
    210                 215                 220                 


Ile Ala Ala Gly Ser Tyr Leu Gly Met Asp Arg Phe Gly Val Asp Val 
225                 230                 235                 240 


Ile Ser Pro Phe Gln Asp Arg Val Asn Ile Val Ala Arg Met Cys Glu 
                245                 250                 255     


Arg Gly His Ala Asp Lys Met Val Leu Ser His Asp Ala Cys Cys Tyr 
            260                 265                 270         


Phe Asp Ala Leu Pro Glu Glu Leu Val Pro Val Ala Met Pro Asn Trp 
        275                 280                 285             


His Tyr Leu His Ile His Asn Asp Val Ile Pro Ala Leu Lys Gln His 
    290                 295                 300                 


Gly Val Thr Asp Glu Gln Leu His Thr Met Leu Val Asp Asn Pro Arg 
305                 310                 315                 320 


Arg Ile Phe Glu Arg Gln Gly Gly Tyr Gln 
                325                 330 


<210>  3
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  3

Met Ile Ser Glu Phe Pro Glu Leu Asn Thr Ala Arg Gly Pro Ile Asp 
1               5                   10                  15      


Thr Ala Asp Leu Gly Val Thr Leu Met His Glu His Val Phe Ile Met 
            20                  25                  30          


Thr Thr Glu Ile Ala Gln Asn Tyr Pro Glu Ala Trp Gly Asp Glu Asp 
        35                  40                  45              


Lys Arg Val Ala Gly Ala Ile Ala Arg Leu Gly Glu Leu Lys Ala Arg 
    50                  55                  60                  


Gly Val Asp Thr Ile Val Asp Leu Thr Val Ile Gly Leu Gly Arg Tyr 
65                  70                  75                  80  


Ile Pro Arg Ile Ala Arg Val Ala Ala Ala Thr Glu Leu Asn Ile Val 
                85                  90                  95      


Val Ala Thr Gly Leu Tyr Thr Tyr Asn Asp Val Pro Phe Tyr Phe His 
            100                 105                 110         


Tyr Leu Gly Pro Gly Ala Gln Leu Asp Gly Pro Glu Ile Met Thr Asp 
        115                 120                 125             


Met Phe Val Arg Asp Ile Glu His Gly Ile Ala Asp Thr Gly Ile Lys 
    130                 135                 140                 


Ala Gly Ile Leu Lys Cys Ala Thr Asp Glu Pro Gly Leu Thr Pro Gly 
145                 150                 155                 160 


Val Glu Arg Val Leu Arg Ala Val Ala Gln Ala Tyr Lys Arg Thr Gly 
                165                 170                 175     


Ala Pro Ile Ser Thr His Thr His Ala Gly Leu Arg Arg Gly Leu Asp 
            180                 185                 190         


Gln Gln Arg Ile Phe Ala Glu Glu Gly Val Asp Leu Ser Arg Val Val 
        195                 200                 205             


Ile Gly His Cys Gly Asp Ser Thr Asp Val Gly Tyr Leu Glu Glu Leu 
    210                 215                 220                 


Ile Ala Ala Gly Ser Tyr Leu Gly Met Asp Arg Phe Gly Val Asp Val 
225                 230                 235                 240 


Ile Ser Pro Phe Gln Asp Arg Val Asn Ile Val Ala Arg Met Cys Glu 
                245                 250                 255     


Arg Gly His Ala Asp Lys Met Val Leu Ser His Asp Ala Cys Cys Tyr 
            260                 265                 270         


Phe Asp Ala Leu Pro Glu Glu Leu Val Pro Val Ala Met Pro Asn Trp 
        275                 280                 285             


His Tyr Leu His Ile His Asn Asp Val Ile Pro Ala Leu Lys Gln His 
    290                 295                 300                 


Gly Val Thr Asp Glu Gln Leu His Thr Met Leu Val Asp Asn Pro Arg 
305                 310                 315                 320 


Arg Ile Phe Glu Arg Gln Gly Gly Tyr Gln 
                325                 330 


<210>  4
<211>  716
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  4

Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      


Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          


Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              


Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  


His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  


Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      


Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         


Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             


Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 


Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 


Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     


Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         


Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             


Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 


Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 


Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     


Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         


Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             


Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 


Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 


Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     


Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         


Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Asn 
        355                 360                 365             


Ser Ser Ser Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Leu Gly Ile 
    370                 375                 380                 


Glu Gly Arg Ile Ser Glu Phe Pro Glu Leu Asn Thr Ala Arg Gly Pro 
385                 390                 395                 400 


Ile Asp Thr Ala Asp Leu Gly Val Thr Leu Met His Glu His Val Phe 
                405                 410                 415     


Ile Met Thr Thr Glu Ile Ala Gln Asn Tyr Pro Glu Ala Trp Gly Asp 
            420                 425                 430         


Glu Asp Lys Arg Val Ala Gly Ala Ile Ala Arg Leu Gly Glu Leu Lys 
        435                 440                 445             


Ala Arg Gly Val Asp Thr Ile Val Asp Leu Thr Val Ile Gly Leu Gly 
    450                 455                 460                 


Arg Tyr Ile Pro Arg Ile Ala Arg Val Ala Ala Ala Thr Glu Leu Asn 
465                 470                 475                 480 


Ile Val Val Ala Thr Gly Leu Tyr Thr Tyr Asn Asp Val Pro Phe Tyr 
                485                 490                 495     


Phe His Tyr Leu Gly Pro Gly Ala Gln Leu Asp Gly Pro Glu Ile Met 
            500                 505                 510         


Thr Asp Met Phe Val Arg Asp Ile Glu His Gly Ile Ala Asp Thr Gly 
        515                 520                 525             


Ile Lys Ala Gly Ile Leu Lys Cys Ala Thr Asp Glu Pro Gly Leu Thr 
    530                 535                 540                 


Pro Gly Val Glu Arg Val Leu Arg Ala Val Ala Gln Ala His Lys Arg 
545                 550                 555                 560 


Thr Gly Ala Pro Ile Ser Thr His Thr His Ala Gly Leu Arg Arg Gly 
                565                 570                 575     


Leu Asp Gln Gln Arg Ile Phe Ala Glu Glu Gly Val Asp Leu Ser Arg 
            580                 585                 590         


Val Val Ile Gly His Cys Gly Asp Ser Thr Asp Val Gly Tyr Leu Glu 
        595                 600                 605             


Glu Leu Ile Ala Ala Gly Ser Tyr Leu Gly Met Asp Arg Phe Gly Val 
    610                 615                 620                 


Asp Val Ile Ser Pro Phe Gln Asp Arg Val Asn Ile Val Ala Arg Met 
625                 630                 635                 640 


Cys Glu Arg Gly His Ala Asp Lys Met Val Leu Ser His Asp Ala Cys 
                645                 650                 655     


Cys Tyr Phe Asp Ala Leu Pro Glu Glu Leu Val Pro Val Ala Met Pro 
            660                 665                 670         


Asn Trp His Tyr Leu His Ile His Asn Asp Val Ile Pro Ala Leu Lys 
        675                 680                 685             


Gln His Gly Val Thr Asp Glu Gln Leu His Thr Met Leu Val Asp Asn 
    690                 695                 700                 


Pro Arg Arg Ile Phe Glu Arg Gln Gly Gly Tyr Gln 
705                 710                 715     


<210>  5
<211>  716
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  5

Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      


Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          


Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              


Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  


His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  


Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      


Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         


Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             


Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 


Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 


Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     


Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         


Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             


Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 


Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 


Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     


Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         


Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             


Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 


Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 


Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     


Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         


Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Asn 
        355                 360                 365             


Ser Ser Ser Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Leu Gly Ile 
    370                 375                 380                 


Glu Gly Arg Ile Ser Glu Phe Pro Glu Leu Asn Thr Ala Arg Gly Pro 
385                 390                 395                 400 


Ile Asp Thr Ala Asp Leu Gly Val Thr Leu Met His Glu His Val Phe 
                405                 410                 415     


Ile Met Thr Thr Glu Ile Ala Gln Asn Tyr Pro Glu Ala Trp Gly Asp 
            420                 425                 430         


Glu Asp Lys Arg Val Ala Gly Ala Ile Ala Arg Leu Val Glu Leu Lys 
        435                 440                 445             


Ala Arg Gly Val Asp Thr Ile Val Asp Leu Thr Val Ile Gly Leu Gly 
    450                 455                 460                 


Arg Tyr Ile Pro Arg Ile Ala Arg Val Ala Ala Ala Thr Glu Leu Asn 
465                 470                 475                 480 


Ile Val Val Ala Thr Gly Leu Tyr Thr Tyr Asn Asp Val Pro Phe Tyr 
                485                 490                 495     


Phe His Tyr Leu Gly Pro Gly Ala Gln Leu Asp Gly Pro Glu Ile Met 
            500                 505                 510         


Thr Asp Met Phe Val Arg Asp Ile Glu His Gly Ile Ala Asp Thr Gly 
        515                 520                 525             


Ile Lys Ala Gly Ile Leu Lys Cys Ala Thr Asp Glu Pro Gly Leu Thr 
    530                 535                 540                 


Pro Gly Val Glu Arg Val Leu Arg Ala Val Ala Gln Ala His Lys Arg 
545                 550                 555                 560 


Thr Gly Ala Pro Ile Ser Thr His Thr His Ala Gly Leu Arg Arg Gly 
                565                 570                 575     


Leu Asp Gln Gln Arg Ile Phe Ala Glu Glu Gly Val Asp Leu Ser Arg 
            580                 585                 590         


Val Val Ile Gly His Cys Gly Asp Ser Thr Asp Val Gly Tyr Leu Glu 
        595                 600                 605             


Glu Leu Ile Ala Ala Gly Ser Tyr Leu Gly Met Asp Arg Phe Gly Val 
    610                 615                 620                 


Asp Val Ile Ser Pro Phe Gln Asp Arg Val Asn Ile Val Ala Arg Met 
625                 630                 635                 640 


Cys Glu Arg Gly His Ala Asp Lys Met Val Leu Ser His Asp Ala Cys 
                645                 650                 655     


Cys Tyr Phe Asp Ala Leu Pro Glu Glu Leu Val Pro Val Ala Met Pro 
            660                 665                 670         


Asn Trp His Tyr Leu His Ile His Asn Asp Val Ile Pro Ala Leu Lys 
        675                 680                 685             


Gln His Gly Val Thr Asp Glu Gln Leu His Thr Met Leu Val Asp Asn 
    690                 695                 700                 


Pro Arg Arg Ile Phe Glu Arg Gln Gly Gly Tyr Gln 
705                 710                 715     


<210>  6
<211>  716
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  6

Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      


Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          


Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              


Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  


His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  


Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      


Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         


Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             


Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 


Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 


Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     


Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         


Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             


Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 


Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 


Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     


Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         


Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             


Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 


Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 


Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     


Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         


Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Asn 
        355                 360                 365             


Ser Ser Ser Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Leu Gly Ile 
    370                 375                 380                 


Glu Gly Arg Ile Ser Glu Phe Pro Glu Leu Asn Thr Ala Arg Gly Pro 
385                 390                 395                 400 


Ile Asp Thr Ala Asp Leu Gly Val Thr Leu Met His Glu His Val Phe 
                405                 410                 415     


Ile Met Thr Thr Glu Ile Ala Gln Asn Tyr Pro Glu Ala Trp Gly Asp 
            420                 425                 430         


Glu Asp Lys Arg Val Ala Gly Ala Ile Ala Arg Leu Gly Glu Leu Lys 
        435                 440                 445             


Ala Arg Gly Val Asp Thr Ile Val Asp Leu Thr Val Ile Gly Leu Gly 
    450                 455                 460                 


Arg Tyr Ile Pro Arg Ile Ala Arg Val Ala Ala Ala Thr Glu Leu Asn 
465                 470                 475                 480 


Ile Val Val Ala Thr Gly Leu Tyr Thr Tyr Asn Asp Val Pro Phe Tyr 
                485                 490                 495     


Phe His Tyr Leu Gly Pro Gly Ala Gln Leu Asp Gly Pro Glu Ile Met 
            500                 505                 510         


Thr Asp Met Phe Val Arg Asp Ile Glu His Gly Ile Ala Asp Thr Gly 
        515                 520                 525             


Ile Lys Ala Gly Ile Leu Lys Cys Ala Thr Asp Glu Pro Gly Leu Thr 
    530                 535                 540                 


Pro Gly Val Glu Arg Val Leu Arg Ala Val Ala Gln Ala Tyr Lys Arg 
545                 550                 555                 560 


Thr Gly Ala Pro Ile Ser Thr His Thr His Ala Gly Leu Arg Arg Gly 
                565                 570                 575     


Leu Asp Gln Gln Arg Ile Phe Ala Glu Glu Gly Val Asp Leu Ser Arg 
            580                 585                 590         


Val Val Ile Gly His Cys Gly Asp Ser Thr Asp Val Gly Tyr Leu Glu 
        595                 600                 605             


Glu Leu Ile Ala Ala Gly Ser Tyr Leu Gly Met Asp Arg Phe Gly Val 
    610                 615                 620                 


Asp Val Ile Ser Pro Phe Gln Asp Arg Val Asn Ile Val Ala Arg Met 
625                 630                 635                 640 


Cys Glu Arg Gly His Ala Asp Lys Met Val Leu Ser His Asp Ala Cys 
                645                 650                 655     


Cys Tyr Phe Asp Ala Leu Pro Glu Glu Leu Val Pro Val Ala Met Pro 
            660                 665                 670         


Asn Trp His Tyr Leu His Ile His Asn Asp Val Ile Pro Ala Leu Lys 
        675                 680                 685             


Gln His Gly Val Thr Asp Glu Gln Leu His Thr Met Leu Val Asp Asn 
    690                 695                 700                 


Pro Arg Arg Ile Phe Glu Arg Gln Gly Gly Tyr Gln 
705                 710                 715     


