                         SEQUENCE LISTING

<110>  Anastasis Biotec Limited
 
<120>  IMPROVED CELL-PENETRATING PEPTIDES AND FUSION PROTEINS

<130>  N420720WO

<150>  GB2019864.4
<151>  2020-12-16

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Homeodomain consensus sequence

<400>  1

Arg Arg Arg Lys Arg Thr Ala Tyr Thr Arg Tyr Gln Leu Leu Glu Leu 
1               5                   10                  15      


Glu Lys Glu Phe Leu Phe Asn Arg Tyr Leu Thr Arg Arg Arg Arg Ile 
            20                  25                  30          


Glu Leu Ala His Ser Leu Asn Leu Thr Glu Arg His Ile Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Glu Asn 
    50                  55                  60  


<210>  2
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the Antennapedia homeodomain

<400>  2

Arg Lys Arg Gly Arg Gln Thr Tyr Thr Arg Tyr Gln Thr Leu Glu Leu 
1               5                   10                  15      


Glu Lys Glu Phe His Phe Asn Arg Tyr Leu Thr Arg Arg Arg Arg Ile 
            20                  25                  30          


Glu Ile Ala His Ala Leu Cys Leu Thr Glu Arg Gln Ile Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Glu Asn 
    50                  55                  60  


<210>  3
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the Antennapedia homeodomain with 
       conservative substitutions


<220>
<221>  MISC_FEATURE
<222>  (1)..(38)
<223>  Wherein X is K or R

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Wherein X is A, C, G or S

<220>
<221>  MISC_FEATURE
<222>  (40)..(60)
<223>  Wherein X is R or K

<400>  3

Xaa Xaa Xaa Gly Xaa Gln Thr Tyr Thr Xaa Tyr Gln Thr Leu Glu Leu 
1               5                   10                  15      


Glu Xaa Glu Phe His Phe Asn Xaa Tyr Leu Thr Xaa Xaa Xaa Xaa Ile 
            20                  25                  30          


Glu Ile Ala His Ala Leu Xaa Leu Thr Glu Xaa Gln Ile Xaa Ile Trp 
        35                  40                  45              


Phe Gln Asn Xaa Xaa Met Xaa Trp Xaa Xaa Glu Asn 
    50                  55                  60  


<210>  4
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Penetratin

<400>  4

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  5
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  penetratin variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  Wherein X is R or K

<400>  5

Xaa Gln Ile Xaa Ile Trp Phe Gln Asn Xaa Xaa Met Xaa Trp Xaa Xaa 
1               5                   10                  15      


<210>  6
<211>  1016
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Val Leu Pro Thr Cys Pro Met Ala Glu Phe Ala Leu Pro Arg His 
1               5                   10                  15      


Ser Ala Val Met Glu Arg Leu Arg Arg Arg Ile Glu Leu Cys Arg Arg 
            20                  25                  30          


His His Ser Thr Cys Glu Ala Arg Tyr Glu Ala Val Ser Pro Glu Arg 
        35                  40                  45              


Leu Glu Leu Glu Arg Gln His Thr Phe Ala Leu His Gln Arg Cys Ile 
    50                  55                  60                  


Gln Ala Lys Ala Lys Arg Ala Gly Lys His Arg Gln Pro Pro Ala Ala 
65                  70                  75                  80  


Thr Ala Pro Ala Pro Ala Ala Pro Ala Pro Arg Leu Asp Ala Ala Asp 
                85                  90                  95      


Gly Pro Glu His Gly Arg Pro Ala Thr His Leu His Asp Thr Val Lys 
            100                 105                 110         


Arg Asn Leu Asp Ser Ala Thr Ser Pro Gln Asn Gly Asp Gln Gln Asn 
        115                 120                 125             


Gly Tyr Gly Asp Leu Phe Pro Gly His Lys Lys Thr Arg Arg Glu Ala 
    130                 135                 140                 


Pro Leu Gly Val Ala Ile Ser Ser Asn Gly Leu Pro Pro Ala Ser Pro 
145                 150                 155                 160 


Leu Gly Gln Ser Asp Lys Pro Ser Gly Ala Asp Ala Leu Gln Ser Ser 
                165                 170                 175     


Gly Lys His Ser Leu Gly Leu Asp Ser Leu Asn Lys Lys Arg Leu Ala 
            180                 185                 190         


Asp Ser Ser Leu His Leu Asn Gly Gly Ser Asn Pro Ser Glu Ser Phe 
        195                 200                 205             


Pro Leu Ser Leu Asn Lys Glu Leu Lys Gln Glu Pro Val Glu Asp Leu 
    210                 215                 220                 


Pro Cys Met Ile Thr Gly Thr Val Gly Ser Ile Ser Gln Ser Asn Leu 
225                 230                 235                 240 


Met Pro Asp Leu Asn Leu Asn Glu Gln Glu Trp Lys Glu Leu Ile Glu 
                245                 250                 255     


Glu Leu Asn Arg Ser Val Pro Asp Glu Asp Met Lys Asp Leu Phe Asn 
            260                 265                 270         


Glu Asp Phe Glu Glu Lys Lys Asp Pro Glu Ser Ser Gly Ser Ala Thr 
        275                 280                 285             


Gln Thr Pro Leu Ala Gln Asp Ile Asn Ile Lys Thr Glu Phe Ser Pro 
    290                 295                 300                 


Ala Ala Phe Glu Gln Glu Gln Leu Gly Ser Pro Gln Val Arg Ala Gly 
305                 310                 315                 320 


Ser Ala Gly Gln Thr Phe Leu Gly Pro Ser Ser Ala Pro Val Ser Thr 
                325                 330                 335     


Asp Ser Pro Ser Leu Gly Gly Ser Gln Thr Leu Phe His Thr Ser Gly 
            340                 345                 350         


Gln Pro Arg Ala Asp Asn Pro Ser Pro Asn Leu Met Pro Ala Ser Ala 
        355                 360                 365             


Gln Ala Gln Asn Ala Gln Arg Ala Leu Ala Gly Val Val Leu Pro Ser 
    370                 375                 380                 


Gln Gly Pro Gly Gly Ala Ser Glu Leu Ser Ser Ala His Gln Leu Gln 
385                 390                 395                 400 


Gln Ile Ala Ala Lys Gln Lys Arg Glu Gln Met Leu Gln Asn Pro Gln 
                405                 410                 415     


Gln Ala Thr Pro Ala Pro Ala Pro Gly Gln Met Ser Thr Trp Gln Gln 
            420                 425                 430         


Thr Gly Pro Ser His Ser Ser Leu Asp Val Pro Tyr Pro Met Glu Lys 
        435                 440                 445             


Pro Ala Ser Pro Ser Ser Tyr Lys Gln Asp Phe Thr Asn Ser Lys Leu 
    450                 455                 460                 


Leu Met Met Pro Ser Val Asn Lys Ser Ser Pro Arg Pro Gly Gly Pro 
465                 470                 475                 480 


Tyr Leu Gln Pro Ser His Val Asn Leu Leu Ser His Gln Pro Pro Ser 
                485                 490                 495     


Asn Leu Asn Gln Asn Ser Ala Asn Asn Gln Gly Ser Val Leu Asp Tyr 
            500                 505                 510         


Gly Asn Thr Lys Pro Leu Ser His Tyr Lys Ala Asp Cys Gly Gln Gly 
        515                 520                 525             


Ser Pro Gly Ser Gly Gln Ser Lys Pro Ala Leu Met Ala Tyr Leu Pro 
    530                 535                 540                 


Gln Gln Leu Ser His Ile Ser His Glu Gln Asn Ser Leu Phe Leu Met 
545                 550                 555                 560 


Lys Pro Lys Pro Gly Asn Met Pro Phe Arg Ser Leu Val Pro Pro Gly 
                565                 570                 575     


Gln Glu Gln Asn Pro Ser Ser Val Pro Val Gln Ala Gln Ala Thr Ser 
            580                 585                 590         


Val Gly Thr Gln Pro Pro Ala Val Ser Val Ala Ser Ser His Asn Ser 
        595                 600                 605             


Ser Pro Tyr Leu Ser Ser Gln Gln Gln Ala Ala Val Met Lys Gln His 
    610                 615                 620                 


Gln Leu Leu Leu Asp Gln Gln Lys Gln Arg Glu Gln Gln Gln Lys His 
625                 630                 635                 640 


Leu Gln Gln Gln Gln Phe Leu Gln Arg Gln Gln His Leu Leu Ala Glu 
                645                 650                 655     


Gln Glu Lys Gln Gln Phe Gln Arg His Leu Thr Arg Pro Pro Pro Gln 
            660                 665                 670         


Tyr Gln Asp Pro Thr Gln Gly Ser Phe Pro Gln Gln Val Gly Gln Phe 
        675                 680                 685             


Thr Gly Ser Ser Ala Ala Val Pro Gly Met Asn Thr Leu Gly Pro Ser 
    690                 695                 700                 


Asn Ser Ser Cys Pro Arg Val Phe Pro Gln Ala Gly Asn Leu Met Pro 
705                 710                 715                 720 


Met Gly Pro Gly His Ala Ser Val Ser Ser Leu Pro Thr Asn Ser Gly 
                725                 730                 735     


Gln Gln Asp Arg Gly Val Ala Gln Phe Pro Gly Ser Gln Asn Met Pro 
            740                 745                 750         


Gln Ser Ser Leu Tyr Gly Met Ala Ser Gly Ile Thr Gln Ile Val Ala 
        755                 760                 765             


Gln Pro Pro Pro Gln Ala Thr Asn Gly His Ala His Ile Pro Arg Gln 
    770                 775                 780                 


Thr Asn Val Gly Gln Asn Thr Ser Val Ser Ala Ala Tyr Gly Gln Asn 
785                 790                 795                 800 


Ser Leu Gly Ser Ser Gly Leu Ser Gln Gln His Asn Lys Gly Thr Leu 
                805                 810                 815     


Asn Pro Gly Leu Thr Lys Pro Pro Val Pro Arg Val Ser Pro Ala Met 
            820                 825                 830         


Gly Gly Gln Asn Ser Ser Trp Gln His Gln Gly Met Pro Asn Leu Ser 
        835                 840                 845             


Gly Gln Thr Pro Gly Asn Ser Asn Val Ser Pro Phe Thr Ala Ala Ser 
    850                 855                 860                 


Ser Phe His Met Gln Gln Gln Ala His Leu Lys Met Ser Ser Pro Gln 
865                 870                 875                 880 


Phe Ser Gln Ala Val Pro Asn Arg Pro Met Ala Pro Met Ser Ser Ala 
                885                 890                 895     


Ala Ala Val Gly Ser Leu Leu Pro Pro Val Ser Ala Gln Gln Arg Thr 
            900                 905                 910         


Ser Ala Pro Ala Pro Ala Pro Pro Pro Thr Ala Pro Gln Gln Gly Leu 
        915                 920                 925             


Pro Gly Leu Ser Pro Ala Gly Pro Glu Leu Gly Ala Phe Ser Gln Ser 
    930                 935                 940                 


Pro Ala Ser Gln Met Gly Gly Arg Ala Gly Leu His Cys Thr Gln Ala 
945                 950                 955                 960 


Tyr Pro Val Arg Thr Ala Gly Gln Glu Leu Pro Phe Ala Tyr Ser Gly 
                965                 970                 975     


Gln Pro Gly Gly Ser Gly Leu Ser Ser Val Ala Gly His Thr Asp Leu 
            980                 985                 990         


Ile Asp Ser Leu Leu Lys Asn Arg  Thr Ser Glu Glu Trp  Met Ser Asp 
        995                 1000                 1005             


Leu Asp  Asp Leu Leu Gly Ser  Gln 
    1010                 1015     


<210>  7
<211>  1096
<212>  PRT
<213>  Homo sapiens

<400>  7

Gly Arg Ala Glu Ser Ser Asp Arg Glu Arg Glu Ser Thr Leu Gln Leu 
1               5                   10                  15      


Leu Ser Leu Val Gln His Gly Gln Gly Ala Arg Lys Ala Gly Lys His 
            20                  25                  30          


Thr Lys Ala Thr Ala Thr Ala Ala Thr Thr Thr Ala Pro Pro Pro Pro 
        35                  40                  45              


Pro Ala Ala Pro Pro Ala Ala Ser Gln Ala Ala Ala Thr Ala Ala Pro 
    50                  55                  60                  


Pro Pro Pro Pro Asp Tyr His His His His Gln Gln His Leu Leu Asn 
65                  70                  75                  80  


Ser Ser Asn Asn Gly Gly Ser Gly Gly Ile Asn Gly Glu Gln Gln Pro 
                85                  90                  95      


Pro Ala Ser Thr Pro Gly Asp Gln Arg Asn Ser Ala Leu Ile Ala Leu 
            100                 105                 110         


Gln Gly Ser Leu Lys Arg Lys Gln Val Val Asn Leu Ser Pro Ala Asn 
        115                 120                 125             


Ser Lys Arg Pro Asn Gly Phe Val Asp Asn Ser Phe Leu Asp Ile Lys 
    130                 135                 140                 


Arg Ile Arg Val Gly Glu Asn Leu Ser Ala Gly Gln Gly Gly Leu Gln 
145                 150                 155                 160 


Ile Asn Asn Gly Gln Ser Gln Ile Met Ser Gly Thr Leu Pro Met Ser 
                165                 170                 175     


Gln Ala Pro Leu Arg Lys Thr Asn Thr Leu Pro Ser His Thr His Ser 
            180                 185                 190         


Pro Gly Asn Gly Leu Phe Asn Met Gly Leu Lys Glu Val Lys Lys Glu 
        195                 200                 205             


Pro Gly Glu Thr Leu Ser Cys Ser Lys His Met Asp Gly Gln Met Thr 
    210                 215                 220                 


Gln Glu Asn Ile Phe Pro Asn Arg Tyr Gly Asp Asp Pro Gly Glu Gln 
225                 230                 235                 240 


Leu Met Asp Pro Glu Leu Gln Glu Leu Phe Asn Glu Leu Thr Asn Ile 
                245                 250                 255     


Ser Val Pro Pro Met Ser Asp Leu Glu Leu Glu Asn Met Ile Asn Ala 
            260                 265                 270         


Thr Ile Lys Gln Asp Asp Pro Phe Asn Ile Asp Leu Gly Gln Gln Ser 
        275                 280                 285             


Gln Arg Ser Thr Pro Arg Pro Ser Leu Pro Met Glu Lys Ile Val Ile 
    290                 295                 300                 


Lys Ser Glu Tyr Ser Pro Gly Leu Thr Gln Gly Pro Ser Gly Ser Pro 
305                 310                 315                 320 


Gln Leu Arg Pro Pro Ser Ala Gly Pro Ala Phe Ser Met Ala Asn Ser 
                325                 330                 335     


Ala Leu Ser Thr Ser Ser Pro Ile Pro Ser Val Pro Gln Ser Gln Ala 
            340                 345                 350         


Gln Pro Gln Thr Gly Ser Gly Ala Ser Arg Ala Leu Pro Ser Trp Gln 
        355                 360                 365             


Glu Val Ser His Ala Gln Gln Leu Lys Gln Ile Ala Ala Asn Arg Gln 
    370                 375                 380                 


Gln His Ala Arg Met Gln Gln His Gln Gln Gln His Gln Pro Thr Asn 
385                 390                 395                 400 


Trp Ser Ala Leu Pro Ser Ser Ala Gly Pro Ser Pro Gly Pro Phe Gly 
                405                 410                 415     


Gln Glu Lys Ile Pro Ser Pro Ser Phe Gly Gln Gln Thr Phe Ser Pro 
            420                 425                 430         


Gln Ser Ser Pro Met Pro Gly Val Ala Gly Gly Ser Gly Gln Ser Lys 
        435                 440                 445             


Val Met Ala Asn Tyr Met Tyr Lys Ala Gly Pro Ser Ala Gln Gly Gly 
    450                 455                 460                 


His Leu Asp Val Leu Met Gln Gln Lys Pro Gln Asp Leu Ser Arg Ser 
465                 470                 475                 480 


Phe Ile Asn Asn Pro His Pro Ala Met Glu Pro Arg Gln Gly Asn Thr 
                485                 490                 495     


Lys Pro Leu Phe His Phe Asn Ser Asp Gln Ala Asn Gln Gln Met Pro 
            500                 505                 510         


Ser Val Leu Pro Ser Gln Asn Lys Pro Ser Leu Leu His Tyr Thr Gln 
        515                 520                 525             


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    530                 535                 540                 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
545                 550                 555                 560 


Gln Ser Ser Ile Ser Ala Gln Gln Gln Gln Gln Gln Gln Ser Ser Ile 
                565                 570                 575     


Ser Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            580                 585                 590         


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Ser Ser 
        595                 600                 605             


Gln Pro Ala Gln Ser Leu Pro Ser Gln Pro Leu Leu Arg Ser Pro Leu 
    610                 615                 620                 


Pro Leu Gln Gln Lys Leu Leu Leu Gln Gln Met Gln Asn Gln Pro Ile 
625                 630                 635                 640 


Ala Gly Met Gly Tyr Gln Val Ser Gln Gln Gln Arg Gln Asp Gln His 
                645                 650                 655     


Ser Val Val Gly Gln Asn Thr Gly Pro Ser Pro Ser Pro Asn Pro Cys 
            660                 665                 670         


Ser Asn Pro Asn Thr Gly Ser Gly Tyr Met Asn Ser Gln Gln Ser Leu 
        675                 680                 685             


Leu Asn Gln Gln Leu Met Gly Lys Lys Gln Thr Leu Gln Arg Gln Ile 
    690                 695                 700                 


Met Glu Gln Lys Gln Gln Leu Leu Leu Gln Gln Gln Met Leu Ala Asp 
705                 710                 715                 720 


Ala Glu Lys Ile Ala Pro Gln Asp Gln Ile Asn Arg His Leu Ser Arg 
                725                 730                 735     


Pro Pro Pro Asp Tyr Lys Asp Gln Arg Arg Asn Val Gly Asn Met Gln 
            740                 745                 750         


Pro Thr Ala Gln Tyr Ser Gly Gly Ser Ser Thr Ile Ser Leu Asn Ser 
        755                 760                 765             


Asn Gln Ala Leu Ala Asn Pro Val Ser Thr His Thr Ile Leu Thr Pro 
    770                 775                 780                 


Asn Ser Ser Leu Leu Ser Thr Ser His Gly Thr Arg Met Pro Ser Leu 
785                 790                 795                 800 


Ser Thr Ala Val Gln Asn Met Gly Met Tyr Gly Asn Leu Pro Cys Asn 
                805                 810                 815     


Gln Pro Asn Thr Tyr Ser Val Thr Ser Gly Met Asn Gln Leu Thr Gln 
            820                 825                 830         


Gln Arg Asn Pro Lys Gln Leu Leu Ala Asn Gln Asn Asn Pro Met Met 
        835                 840                 845             


Pro Arg Pro Pro Thr Leu Gly Pro Ser Asn Asn Asn Asn Val Ala Thr 
    850                 855                 860                 


Phe Gly Ala Gly Ser Val Gly Asn Ser Gln Gln Leu Arg Pro Asn Leu 
865                 870                 875                 880 


Thr His Ser Met Ala Ser Met Pro Pro Gln Arg Thr Ser Asn Val Met 
                885                 890                 895     


Ile Thr Ser Asn Thr Thr Ala Pro Asn Trp Ala Ser Gln Glu Gly Thr 
            900                 905                 910         


Ser Lys Gln Gln Glu Ala Leu Thr Ser Ala Gly Val Arg Phe Pro Thr 
        915                 920                 925             


Gly Thr Pro Ala Ala Tyr Thr Pro Asn Gln Ser Leu Gln Gln Ala Val 
    930                 935                 940                 


Gly Ser Gln Gln Phe Ser Gln Arg Ala Val Ala Pro Pro Asn Gln Leu 
945                 950                 955                 960 


Thr Pro Ala Val Gln Met Arg Pro Met Asn Gln Met Ser Gln Thr Leu 
                965                 970                 975     


Asn Gly Gln Thr Met Gly Pro Leu Arg Gly Leu Asn Leu Arg Pro Asn 
            980                 985                 990         


Gln Leu Ser Thr Gln Ile Leu Pro  Asn Leu Asn Gln Ser  Gly Thr Gly 
        995                 1000                 1005             


Leu Asn  Gln Ser Arg Thr Gly  Ile Asn Gln Pro Pro  Ser Leu Thr 
    1010                 1015                 1020             


Pro Ser  Asn Phe Pro Ser Pro  Asn Gln Ser Ser Arg  Ala Phe Gln 
    1025                 1030                 1035             


Gly Thr  Asp His Ser Ser Asp  Leu Ala Phe Asp Phe  Leu Ser Gln 
    1040                 1045                 1050             


Gln Asn  Asp Asn Met Gly Pro  Ala Leu Asn Ser Asp  Ala Asp Phe 
    1055                 1060                 1065             


Ile Asp  Ser Leu Leu Lys Thr  Glu Pro Gly Asn Asp  Asp Trp Met 
    1070                 1075                 1080             


Lys Asp  Ile Asn Leu Asp Glu  Ile Leu Gly Asn Asn  Ser 
    1085                 1090                 1095     


<210>  8
<211>  1133
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Gly Asp Phe Ala Ala Pro Ala Ala Ala Ala Asn Gly Ser Ser Ile 
1               5                   10                  15      


Cys Ile Asn Ser Ser Leu Asn Ser Ser Leu Gly Gly Ala Gly Ile Gly 
            20                  25                  30          


Val Asn Asn Thr Pro Asn Ser Thr Pro Ala Ala Pro Ser Ser Asn His 
        35                  40                  45              


Pro Ala Ala Gly Gly Cys Gly Gly Ser Gly Gly Pro Gly Gly Gly Ser 
    50                  55                  60                  


Ala Ala Val Pro Lys His Ser Thr Val Val Glu Arg Leu Arg Gln Arg 
65                  70                  75                  80  


Ile Glu Gly Cys Arg Arg His His Val Asn Cys Glu Asn Arg Tyr Gln 
                85                  90                  95      


Gln Ala Gln Val Glu Gln Leu Glu Leu Glu Arg Arg Asp Thr Val Ser 
            100                 105                 110         


Leu Tyr Gln Arg Thr Leu Glu Gln Arg Ala Lys Lys Ser Gly Ala Gly 
        115                 120                 125             


Thr Gly Lys Gln Gln His Pro Ser Lys Pro Gln Gln Asp Ala Glu Ala 
    130                 135                 140                 


Ala Ser Ala Glu Gln Arg Asn His Thr Leu Ile Met Leu Gln Glu Thr 
145                 150                 155                 160 


Val Lys Arg Lys Leu Glu Gly Ala Arg Ser Pro Leu Asn Gly Asp Gln 
                165                 170                 175     


Gln Asn Gly Ala Cys Asp Gly Asn Phe Ser Pro Thr Ser Lys Arg Ile 
            180                 185                 190         


Arg Lys Asp Ile Ser Ala Gly Met Glu Ala Ile Asn Asn Leu Pro Ser 
        195                 200                 205             


Asn Met Pro Leu Pro Ser Ala Ser Pro Leu His Gln Leu Asp Leu Lys 
    210                 215                 220                 


Pro Ser Leu Pro Leu Gln Asn Ser Gly Thr His Thr Pro Gly Leu Leu 
225                 230                 235                 240 


Glu Asp Leu Ser Lys Asn Gly Arg Leu Pro Glu Ile Lys Leu Pro Val 
                245                 250                 255     


Asn Gly Cys Ser Asp Leu Glu Asp Ser Phe Thr Ile Leu Gln Ser Lys 
            260                 265                 270         


Asp Leu Lys Gln Glu Pro Leu Asp Asp Pro Thr Cys Ile Asp Thr Ser 
        275                 280                 285             


Glu Thr Ser Leu Ser Asn Gln Asn Lys Leu Phe Ser Asp Ile Asn Leu 
    290                 295                 300                 


Asn Asp Gln Glu Trp Gln Glu Leu Ile Asp Glu Leu Ala Asn Thr Val 
305                 310                 315                 320 


Pro Glu Asp Asp Ile Gln Asp Leu Phe Asn Glu Asp Phe Glu Glu Lys 
                325                 330                 335     


Lys Glu Pro Glu Phe Ser Gln Pro Ala Thr Glu Thr Pro Leu Ser Gln 
            340                 345                 350         


Glu Ser Ala Ser Val Lys Ser Asp Pro Ser His Ser Pro Phe Ala His 
        355                 360                 365             


Val Ser Met Gly Ser Pro Gln Ala Arg Pro Ser Ser Ser Gly Pro Pro 
    370                 375                 380                 


Phe Ser Thr Val Ser Thr Ala Thr Ser Leu Pro Ser Val Ala Ser Thr 
385                 390                 395                 400 


Pro Ala Ala Pro Asn Pro Ala Ser Ser Pro Ala Asn Cys Ala Val Gln 
                405                 410                 415     


Ser Pro Gln Thr Pro Asn Gln Ala His Thr Pro Gly Gln Ala Pro Pro 
            420                 425                 430         


Arg Pro Gly Asn Gly Tyr Leu Leu Asn Pro Ala Ala Val Thr Val Ala 
        435                 440                 445             


Gly Ser Ala Ser Gly Pro Val Ala Val Pro Ser Ser Asp Met Ser Pro 
    450                 455                 460                 


Ala Glu Gln Leu Lys Gln Met Ala Ala Gln Gln Gln Gln Arg Ala Lys 
465                 470                 475                 480 


Leu Met Gln Gln Lys Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
                485                 490                 495     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Ser Asn Gln Thr Ser 
            500                 505                 510         


Asn Trp Ser Pro Leu Gly Pro Pro Ser Ser Pro Tyr Gly Ala Ala Phe 
        515                 520                 525             


Thr Ala Glu Lys Pro Asn Ser Pro Met Met Tyr Pro Gln Ala Phe Asn 
    530                 535                 540                 


Asn Gln Asn Pro Ile Val Pro Pro Met Ala Asn Asn Leu Gln Lys Thr 
545                 550                 555                 560 


Thr Met Asn Asn Tyr Leu Pro Gln Asn His Met Asn Met Ile Asn Gln 
                565                 570                 575     


Gln Pro Asn Asn Leu Gly Thr Asn Ser Leu Asn Lys Gln His Asn Ile 
            580                 585                 590         


Leu Thr Tyr Gly Asn Thr Lys Pro Leu Thr His Phe Asn Ala Asp Leu 
        595                 600                 605             


Ser Gln Arg Met Thr Pro Pro Val Ala Asn Pro Asn Lys Asn Pro Leu 
    610                 615                 620                 


Met Pro Tyr Ile Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
625                 630                 635                 640 


Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Gln Leu Gln Ala Pro Arg 
                645                 650                 655     


Ala His Leu Ser Glu Asp Gln Lys Arg Leu Leu Leu Met Lys Gln Lys 
            660                 665                 670         


Gly Val Met Asn Gln Pro Met Ala Tyr Ala Ala Leu Pro Ser His Gly 
        675                 680                 685             


Gln Glu Gln His Pro Val Gly Leu Pro Arg Thr Thr Gly Pro Met Gln 
    690                 695                 700                 


Ser Ser Val Pro Pro Gly Ser Gly Gly Met Val Ser Gly Ala Ser Pro 
705                 710                 715                 720 


Ala Gly Pro Gly Phe Leu Gly Ser Gln Pro Gln Ala Ala Ile Met Lys 
                725                 730                 735     


Gln Met Leu Ile Asp Gln Arg Ala Gln Leu Ile Glu Gln Gln Lys Gln 
            740                 745                 750         


Gln Phe Leu Arg Glu Gln Arg Gln Gln Gln Gln Gln Gln Gln Gln Ile 
        755                 760                 765             


Leu Ala Glu Gln Gln Leu Gln Gln Ser His Leu Pro Arg Gln His Leu 
    770                 775                 780                 


Gln Pro Gln Arg Asn Pro Tyr Pro Val Gln Gln Val Asn Gln Phe Gln 
785                 790                 795                 800 


Gly Ser Pro Gln Asp Ile Ala Ala Val Arg Ser Gln Ala Ala Leu Gln 
                805                 810                 815     


Ser Met Arg Thr Ser Arg Leu Met Ala Gln Asn Ala Gly Met Met Gly 
            820                 825                 830         


Ile Gly Pro Ser Gln Asn Pro Gly Thr Met Ala Thr Ala Ala Ala Gln 
        835                 840                 845             


Ser Glu Met Gly Leu Ala Pro Tyr Ser Thr Thr Pro Thr Ser Gln Pro 
    850                 855                 860                 


Gly Met Tyr Asn Met Ser Thr Gly Met Thr Gln Met Leu Gln His Pro 
865                 870                 875                 880 


Asn Gln Ser Gly Met Ser Ile Thr His Asn Gln Ala Gln Gly Pro Arg 
                885                 890                 895     


Gln Pro Ala Ser Gly Gln Gly Val Gly Met Val Ser Gly Phe Gly Gln 
            900                 905                 910         


Ser Met Leu Val Asn Ser Ala Ile Thr Gln Gln His Pro Gln Met Lys 
        915                 920                 925             


Gly Pro Val Gly Gln Ala Leu Pro Arg Pro Gln Ala Pro Pro Arg Leu 
    930                 935                 940                 


Gln Ser Leu Met Gly Thr Val Gln Gln Gly Ala Gln Ser Trp Gln Gln 
945                 950                 955                 960 


Arg Ser Leu Gln Gly Met Pro Gly Arg Thr Ser Gly Glu Leu Gly Pro 
                965                 970                 975     


Phe Asn Asn Gly Ala Ser Tyr Pro Leu Gln Ala Gly Gln Pro Arg Leu 
            980                 985                 990         


Thr Lys Gln His Phe Pro Gln Gly  Leu Ser Gln Ser Val  Val Asp Ala 
        995                 1000                 1005             


Asn Thr  Gly Thr Val Arg Thr  Leu Asn Pro Ala Ala  Met Gly Arg 
    1010                 1015                 1020             


Gln Met  Met Pro Ser Leu Pro  Gly Gln Gln Gly Thr  Ser Gln Ala 
    1025                 1030                 1035             


Arg Pro  Met Val Met Ser Gly  Leu Ser Gln Gly Val  Pro Gly Met 
    1040                 1045                 1050             


Pro Ala  Phe Ser Gln Pro Pro  Ala Gln Gln Gln Ile  Pro Ser Gly 
    1055                 1060                 1065             


Ser Phe  Ala Pro Ser Ser Gln  Ser Gln Ala Tyr Glu  Arg Asn Ala 
    1070                 1075                 1080             


Pro Gln  Asp Val Ser Tyr Asn  Tyr Ser Gly Asp Gly  Ala Gly Gly 
    1085                 1090                 1095             


Ser Phe  Pro Gly Leu Pro Asp  Gly Ala Asp Leu Val  Asp Ser Ile 
    1100                 1105                 1110             


Ile Lys  Gly Gly Pro Gly Asp  Glu Trp Met Gln Glu  Leu Asp Glu 
    1115                 1120                 1125             


Leu Phe  Gly Asn Pro 
    1130             


<210>  9
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dnMAML(13-74)

<400>  9

Leu Pro Arg His Ser Ala Val Met Glu Arg Leu Arg Arg Arg Ile Glu 
1               5                   10                  15      


Leu Cys Arg Arg His His Ser Thr Cys Glu Ala Arg Tyr Glu Ala Val 
            20                  25                  30          


Ser Pro Glu Arg Leu Glu Leu Glu Arg Gln His Thr Phe Ala Leu His 
        35                  40                  45              


Gln Arg Cys Ile Gln Ala Lys Ala Lys Arg Ala Gly Lys His 
    50                  55                  60          


<210>  10
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTP-dnMAML conjugate

<400>  10

Arg Lys Arg Gly Arg Gln Thr Tyr Thr Arg Tyr Gln Thr Leu Glu Leu 
1               5                   10                  15      


Glu Lys Glu Phe His Phe Asn Arg Tyr Leu Thr Arg Arg Arg Arg Ile 
            20                  25                  30          


Glu Ile Ala His Ala Leu Cys Leu Thr Glu Arg Gln Ile Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Glu Asn Gly Glu Phe Met 
    50                  55                  60                  


Ala Leu Pro Arg His Ser Ala Val Met Glu Arg Leu Arg Arg Arg Ile 
65                  70                  75                  80  


Glu Leu Cys Arg Arg His His Ser Thr Cys Glu Ala Arg Tyr Glu Ala 
                85                  90                  95      


Val Ser Pro Glu Arg Leu Glu Leu Glu Arg Gln His Thr Phe Ala Leu 
            100                 105                 110         


His Gln Arg Cys Ile Gln Ala Lys Ala Lys Arg Ala Gly Lys His 
        115                 120                 125         


<210>  11
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  penetratin-dnMAML conjugate

<400>  11

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Glu Asn Gly Glu Phe Met Ala Leu Pro Arg His Ser Ala Val Met Glu 
            20                  25                  30          


Arg Leu Arg Arg Arg Ile Glu Leu Cys Arg Arg His His Ser Thr Cys 
        35                  40                  45              


Glu Ala Arg Tyr Glu Ala Val Ser Pro Glu Arg Leu Glu Leu Glu Arg 
    50                  55                  60                  


Gln His Thr Phe Ala Leu His Gln Arg Cys Ile Gln Ala Lys Ala Lys 
65                  70                  75                  80  


Arg Ala Gly Lys His 
                85  


<210>  12
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His-ANTP-dnMAML conjugate (Syntana-4)

<400>  12

Met His His His His His His Gly Ser Arg Lys Arg Gly Arg Gln Thr 
1               5                   10                  15      


Tyr Thr Arg Tyr Gln Thr Leu Glu Leu Glu Lys Glu Phe His Phe Asn 
            20                  25                  30          


Arg Tyr Leu Thr Arg Arg Arg Arg Ile Glu Ile Ala His Ala Leu Cys 
        35                  40                  45              


Leu Thr Glu Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys 
    50                  55                  60                  


Trp Lys Lys Glu Asn Gly Glu Phe Met Ala Leu Pro Arg His Ser Ala 
65                  70                  75                  80  


Val Met Glu Arg Leu Arg Arg Arg Ile Glu Leu Cys Arg Arg His His 
                85                  90                  95      


Ser Thr Cys Glu Ala Arg Tyr Glu Ala Val Ser Pro Glu Arg Leu Glu 
            100                 105                 110         


Leu Glu Arg Gln His Thr Phe Ala Leu His Gln Arg Cys Ile Gln Ala 
        115                 120                 125             


Lys Ala Lys Arg Ala Gly Lys His 
    130                 135     


<210>  13
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of ANTP variant

<400>  13

Arg Lys Arg Gly Arg Gln Thr Tyr Thr Arg Tyr Gln Thr Leu Glu Leu 
1               5                   10                  15      


Glu Lys Glu Phe His Phe Asn Arg Tyr Leu Thr Arg Arg Arg Arg Ile 
            20                  25                  30          


Glu Ile Ala His Ala Leu Ser Leu Thr Glu Arg Gln Ile Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Glu Asn Cys 
    50                  55                  60      


<210>  14
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of ANTP variant

<400>  14

Cys Arg Lys Arg Gly Arg Gln Thr Tyr Thr Arg Tyr Gln Thr Leu Glu 
1               5                   10                  15      


Leu Glu Lys Glu Phe His Phe Asn Arg Tyr Leu Thr Arg Arg Arg Arg 
            20                  25                  30          


Ile Glu Ile Ala His Ala Leu Ser Leu Thr Glu Arg Gln Ile Lys Ile 
        35                  40                  45              


Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Glu Asn 
    50                  55                  60      


<210>  15
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of ANTP variant

<400>  15

Cys Arg Lys Arg Gly Arg Gln Thr Tyr Thr Arg Tyr Gln Thr Leu Glu 
1               5                   10                  15      


Leu Glu Lys Glu Phe His Phe Asn Arg Tyr Leu Thr Arg Arg Arg Arg 
            20                  25                  30          


Ile Glu Ile Ala His Ala Leu Ser Leu Thr Glu Arg Gln Ile Lys Ile 
        35                  40                  45              


Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Glu Asn Cys 
    50                  55                  60          


<210>  16
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTP variant

<400>  16

Arg Lys Arg Gly Arg Gln Thr Tyr Thr Arg Tyr Gln Thr Leu Glu Leu 
1               5                   10                  15      


Glu Lys Glu Phe His Phe Asn Arg Tyr Leu Thr Arg Arg Arg Arg Ile 
            20                  25                  30          


Glu Ile Ala His Ala Leu Ser Leu Thr Glu Arg Gln Ile Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Glu Asn 
    50                  55                  60  


<210>  17
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of an amphipathic model peptide

<400>  17

Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210>  18
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary flexible linker

<400>  18

Gly Gly Gly Gly Ser 
1               5   


<210>  19
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gly and Ser rich flexible linker

<400>  19

Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe 
1               5                   10          


