               SEQUENCE LISTING

<110> ORION CORPORATION

<120> Chimeric antigen receptor (CAR) spacer modifications enhance CAR T cell functionality

<130> CAR SPACER

<150> FI20206315
<151> 2020-12-16

<160> 84

<170> BiSSAP 1.3.6

<210> 1
<211> 100
<212> PRT
<213> Homo sapiens


<400> 1
Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala Thr Pro Gln 
1               5                   10                  15      
His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro Arg Asp 
            20                  25                  30          
Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp Phe Gln 
        35                  40                  45              
Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser Ile His Ser 
    50                  55                  60                  
Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser Gln Val Ile 
65                  70                  75                  80  
Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu Arg Gly Thr 
                85                  90                  95      
Ala Asn Leu Ser 
            100 

<210> 2
<211> 95
<212> PRT
<213> Homo sapiens


<400> 2
Pro Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val 
1               5                   10                  15      
Asn Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu 
            20                  25                  30          
Thr Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr 
        35                  40                  45              
Val Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu 
    50                  55                  60                  
Val Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val 
65                  70                  75                  80  
Glu His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys 
                85                  90                  95  

<210> 3
<211> 17
<212> PRT
<213> Homo sapiens


<400> 3
Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys 
1               5                   10                  15      
Pro 
    

<210> 4
<211> 25
<212> PRT
<213> Homo sapiens


<400> 4
Tyr Val Thr Val Ser Ser Gln Asp Pro Ala Glu Pro Lys Ser Pro Asp 
1               5                   10                  15      
Lys Thr His Thr Cys Pro Pro Cys Pro 
            20                  25  

<210> 5
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 5
Gly Gly Gly Gly Ser 
1               5   

<210> 6
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 6
Gly Gly Gly Gly Ser Val Pro 
1               5           

<210> 7
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 7
Gly Gly Gly Gly Ser Ala Lys 
1               5           

<210> 8
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 8
Val Ser Gly Gly Gly Gly Ser 
1               5           

<210> 9
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker C1

<400> 9
Glu Thr Ile Arg Val Pro 
1               5       

<210> 10
<211> 42
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAR spacer XS

<400> 10
Tyr Val Thr Val Ser Ser Gln Asp Pro Ala Glu Pro Lys Ser Pro Asp 
1               5                   10                  15      
Lys Thr His Thr Cys Pro Pro Cys Pro Lys Gly Lys His Leu Cys Pro 
            20                  25                  30          
Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro 
        35                  40          

<210> 11
<211> 132
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAR spacer 1S

<400> 11
Tyr Val Thr Val Ser Ser Gln Asp Pro Ala Glu Pro Lys Ser Pro Asp 
1               5                   10                  15      
Lys Thr His Thr Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Ala Lys 
            20                  25                  30          
Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala Thr Pro Gln 
        35                  40                  45              
His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro Arg Asp 
    50                  55                  60                  
Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp Phe Gln 
65                  70                  75                  80  
Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser Ile His Ser 
                85                  90                  95      
Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser Gln Val Ile 
            100                 105                 110         
Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu Arg Gly Thr 
        115                 120                 125             
Ala Asn Leu Ser 
    130         

<210> 12
<211> 129
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAR spacer 2S

<400> 12
Tyr Val Thr Val Ser Ser Gln Asp Pro Ala Glu Pro Lys Ser Pro Asp 
1               5                   10                  15      
Lys Thr His Thr Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Val Pro 
            20                  25                  30          
Pro Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val 
        35                  40                  45              
Asn Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu 
    50                  55                  60                  
Thr Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr 
65                  70                  75                  80  
Val Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu 
                85                  90                  95      
Val Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val 
            100                 105                 110         
Glu His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val 
        115                 120                 125             
Ser 
    

<210> 13
<211> 154
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAR spacer X1S

<400> 13
Tyr Val Thr Val Ser Ser Gln Asp Pro Ala Glu Pro Lys Ser Pro Asp 
1               5                   10                  15      
Lys Thr His Thr Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Ala Lys 
            20                  25                  30          
Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala Thr Pro Gln 
        35                  40                  45              
His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro Arg Asp 
    50                  55                  60                  
Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp Phe Gln 
65                  70                  75                  80  
Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser Ile His Ser 
                85                  90                  95      
Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser Gln Val Ile 
            100                 105                 110         
Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu Arg Gly Thr 
        115                 120                 125             
Ala Asn Leu Ser Gly Gly Gly Gly Ser Lys Gly Lys His Leu Cys Pro 
    130                 135                 140                 
Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro 
145                 150                 

<210> 14
<211> 146
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAR spacer X2S

<400> 14
Tyr Val Thr Val Ser Ser Gln Asp Pro Ala Glu Pro Lys Ser Pro Asp 
1               5                   10                  15      
Lys Thr His Thr Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Val Pro 
            20                  25                  30          
Pro Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val 
        35                  40                  45              
Asn Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu 
    50                  55                  60                  
Thr Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr 
65                  70                  75                  80  
Val Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu 
                85                  90                  95      
Val Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val 
            100                 105                 110         
Glu His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val 
        115                 120                 125             
Ser Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser 
    130                 135                 140                 
Lys Pro 
145     

<210> 15
<211> 235
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAR spacer M

<400> 15
Tyr Val Thr Val Ser Ser Gln Asp Pro Ala Glu Pro Lys Ser Pro Asp 
1               5                   10                  15      
Lys Thr His Thr Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Ala Lys 
            20                  25                  30          
Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala Thr Pro Gln 
        35                  40                  45              
His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro Arg Asp 
    50                  55                  60                  
Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp Phe Gln 
65                  70                  75                  80  
Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser Ile His Ser 
                85                  90                  95      
Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser Gln Val Ile 
            100                 105                 110         
Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu Arg Gly Thr 
        115                 120                 125             
Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu Glu Val Thr 
    130                 135                 140                 
Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr Cys Gln Val 
145                 150                 155                 160 
Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu Glu Asn Gly 
                165                 170                 175     
Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu Asn Lys Asp 
            180                 185                 190         
Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val Ser Ala His 
        195                 200                 205             
Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp Gly Gln Pro 
    210                 215                 220                 
Ala Val Ser Lys Ser His Asp Leu Lys Val Ser 
225                 230                 235 

<210> 16
<211> 252
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAR spacer XM

<400> 16
Tyr Val Thr Val Ser Ser Gln Asp Pro Ala Glu Pro Lys Ser Pro Asp 
1               5                   10                  15      
Lys Thr His Thr Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Ala Lys 
            20                  25                  30          
Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala Thr Pro Gln 
        35                  40                  45              
His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro Arg Asp 
    50                  55                  60                  
Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp Phe Gln 
65                  70                  75                  80  
Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser Ile His Ser 
                85                  90                  95      
Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser Gln Val Ile 
            100                 105                 110         
Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu Arg Gly Thr 
        115                 120                 125             
Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu Glu Val Thr 
    130                 135                 140                 
Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr Cys Gln Val 
145                 150                 155                 160 
Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu Glu Asn Gly 
                165                 170                 175     
Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu Asn Lys Asp 
            180                 185                 190         
Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val Ser Ala His 
        195                 200                 205             
Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp Gly Gln Pro 
    210                 215                 220                 
Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Lys Gly Lys His Leu 
225                 230                 235                 240 
Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro 
                245                 250         

<210> 17
<211> 339
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAR spacer L

<400> 17
Tyr Val Thr Val Ser Ser Gln Asp Pro Ala Glu Pro Lys Ser Pro Asp 
1               5                   10                  15      
Lys Thr His Thr Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Val Pro 
            20                  25                  30          
Pro Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val 
        35                  40                  45              
Asn Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu 
    50                  55                  60                  
Thr Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr 
65                  70                  75                  80  
Val Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu 
                85                  90                  95      
Val Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val 
            100                 105                 110         
Glu His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Ala Lys Pro Ser Ala Pro Val Val Ser Gly 
    130                 135                 140                 
Pro Ala Ala Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu 
145                 150                 155                 160 
Ser His Gly Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn 
                165                 170                 175     
Gly Asn Glu Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu 
            180                 185                 190         
Ser Val Ser Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg 
        195                 200                 205             
Glu Asp Val His Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu 
    210                 215                 220                 
Gln Gly Asp Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg 
225                 230                 235                 240 
Val Pro Pro Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn 
                245                 250                 255     
Gln Val Asn Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu 
            260                 265                 270         
Gln Leu Thr Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala 
        275                 280                 285             
Ser Thr Val Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp 
    290                 295                 300                 
Leu Leu Val Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys 
305                 310                 315                 320 
Gln Val Glu His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu 
                325                 330                 335     
Lys Val Ser 
            

<210> 18
<211> 356
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAR spacer XL

<400> 18
Tyr Val Thr Val Ser Ser Gln Asp Pro Ala Glu Pro Lys Ser Pro Asp 
1               5                   10                  15      
Lys Thr His Thr Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Val Pro 
            20                  25                  30          
Pro Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val 
        35                  40                  45              
Asn Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu 
    50                  55                  60                  
Thr Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr 
65                  70                  75                  80  
Val Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu 
                85                  90                  95      
Val Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val 
            100                 105                 110         
Glu His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Ala Lys Pro Ser Ala Pro Val Val Ser Gly 
    130                 135                 140                 
Pro Ala Ala Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu 
145                 150                 155                 160 
Ser His Gly Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn 
                165                 170                 175     
Gly Asn Glu Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu 
            180                 185                 190         
Ser Val Ser Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg 
        195                 200                 205             
Glu Asp Val His Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu 
    210                 215                 220                 
Gln Gly Asp Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg 
225                 230                 235                 240 
Val Pro Pro Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn 
                245                 250                 255     
Gln Val Asn Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu 
            260                 265                 270         
Gln Leu Thr Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala 
        275                 280                 285             
Ser Thr Val Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp 
    290                 295                 300                 
Leu Leu Val Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys 
305                 310                 315                 320 
Gln Val Glu His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu 
                325                 330                 335     
Lys Val Ser Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly 
            340                 345                 350         
Pro Ser Lys Pro 
        355     

<210> 19
<211> 108
<212> PRT
<213> Homo sapiens


<400> 19
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              
Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             

<210> 20
<211> 120
<212> PRT
<213> Homo sapiens


<400> 20
Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          
Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  
Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      
Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 

<210> 21
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 21
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      
Gly Gly Gly Ser 
            20  

<210> 22
<211> 248
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFV anti-CD19

<400> 22
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              
Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly Gly Gly 
            100                 105                 110         
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             
Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
    130                 135                 140                 
Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
145                 150                 155                 160 
Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
                165                 170                 175     
Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
            180                 185                 190         
Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
        195                 200                 205             
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
    210                 215                 220                 
Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
225                 230                 235                 240 
Gly Thr Thr Val Thr Val Ser Ser 
                245             

<210> 23
<211> 27
<212> PRT
<213> Homo sapiens


<400> 23
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      
Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          

<210> 24
<211> 41
<212> PRT
<213> Homo sapiens


<400> 24
Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      
Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          
Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      

<210> 25
<211> 112
<212> PRT
<213> Homo sapiens


<400> 25
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              
Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  
Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  
Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      
Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         



<210> 26
<211> 491
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAR XS

<400> 26
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Ser Arg Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          
Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              
Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  
Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      
Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         
Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             
Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu 
145                 150                 155                 160 
Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val 
                165                 170                 175     
Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys 
            180                 185                 190         
Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr 
        195                 200                 205             
Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys 
    210                 215                 220                 
Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala 
225                 230                 235                 240 
Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met 
                245                 250                 255     
Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Tyr Val Thr 
            260                 265                 270         
Val Ser Ser Gln Asp Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr His 
        275                 280                 285             
Thr Cys Pro Pro Cys Pro Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
    290                 295                 300                 
Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
305                 310                 315                 320 
Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
                325                 330                 335     
Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
            340                 345                 350         
Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
        355                 360                 365             
Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser 
    370                 375                 380                 
Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 
Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     
Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            420                 425                 430         
Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             
Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 
His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 
Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490     

<210> 27
<211> 586
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAR 1S

<400> 27
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Ser Arg Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          
Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              
Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  
Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      
Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         
Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             
Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu 
145                 150                 155                 160 
Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val 
                165                 170                 175     
Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys 
            180                 185                 190         
Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr 
        195                 200                 205             
Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys 
    210                 215                 220                 
Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala 
225                 230                 235                 240 
Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met 
                245                 250                 255     
Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Tyr Val Thr 
            260                 265                 270         
Val Ser Ser Gln Asp Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr His 
        275                 280                 285             
Thr Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Ala Lys Pro Ser Ala 
    290                 295                 300                 
Pro Val Val Ser Gly Pro Ala Ala Arg Ala Thr Pro Gln His Thr Val 
305                 310                 315                 320 
Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro Arg Asp Ile Thr Leu 
                325                 330                 335     
Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp Phe Gln Thr Asn Val 
            340                 345                 350         
Asp Pro Val Gly Glu Ser Val Ser Tyr Ser Ile His Ser Thr Ala Lys 
        355                 360                 365             
Val Val Leu Thr Arg Glu Asp Val His Ser Gln Val Ile Cys Glu Val 
    370                 375                 380                 
Ala His Val Thr Leu Gln Gly Asp Pro Leu Arg Gly Thr Ala Asn Leu 
385                 390                 395                 400 
Ser Gly Gly Gly Gly Ser Phe Trp Val Leu Val Val Val Gly Gly Val 
                405                 410                 415     
Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
            420                 425                 430         
Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
        435                 440                 445             
Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
    450                 455                 460                 
Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg 
465                 470                 475                 480 
Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
                485                 490                 495     
Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
            500                 505                 510         
Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
        515                 520                 525             
Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
    530                 535                 540                 
Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
545                 550                 555                 560 
Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
                565                 570                 575     
Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            580                 585     

<210> 28
<211> 583
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAR 2S

<400> 28
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Ser Arg Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          
Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              
Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  
Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      
Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         
Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             
Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu 
145                 150                 155                 160 
Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val 
                165                 170                 175     
Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys 
            180                 185                 190         
Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr 
        195                 200                 205             
Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys 
    210                 215                 220                 
Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala 
225                 230                 235                 240 
Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met 
                245                 250                 255     
Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Tyr Val Thr 
            260                 265                 270         
Val Ser Ser Gln Asp Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr His 
        275                 280                 285             
Thr Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Val Pro Pro Thr Leu 
    290                 295                 300                 
Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr 
305                 310                 315                 320 
Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu 
                325                 330                 335     
Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu 
            340                 345                 350         
Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val 
        355                 360                 365             
Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp 
    370                 375                 380                 
Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Gly Gly 
385                 390                 395                 400 
Gly Gly Ser Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
                405                 410                 415     
Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
            420                 425                 430         
Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
        435                 440                 445             
Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
    450                 455                 460                 
Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
465                 470                 475                 480 
Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
                485                 490                 495     
Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
            500                 505                 510         
Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
        515                 520                 525             
Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
    530                 535                 540                 
Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
545                 550                 555                 560 
Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
                565                 570                 575     
Met Gln Ala Leu Pro Pro Arg 
            580             

<210> 29
<211> 603
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAR X1S

<400> 29
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Ser Arg Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          
Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              
Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  
Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      
Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         
Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             
Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu 
145                 150                 155                 160 
Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val 
                165                 170                 175     
Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys 
            180                 185                 190         
Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr 
        195                 200                 205             
Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys 
    210                 215                 220                 
Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala 
225                 230                 235                 240 
Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met 
                245                 250                 255     
Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Tyr Val Thr 
            260                 265                 270         
Val Ser Ser Gln Asp Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr His 
        275                 280                 285             
Thr Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Ala Lys Pro Ser Ala 
    290                 295                 300                 
Pro Val Val Ser Gly Pro Ala Ala Arg Ala Thr Pro Gln His Thr Val 
305                 310                 315                 320 
Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro Arg Asp Ile Thr Leu 
                325                 330                 335     
Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp Phe Gln Thr Asn Val 
            340                 345                 350         
Asp Pro Val Gly Glu Ser Val Ser Tyr Ser Ile His Ser Thr Ala Lys 
        355                 360                 365             
Val Val Leu Thr Arg Glu Asp Val His Ser Gln Val Ile Cys Glu Val 
    370                 375                 380                 
Ala His Val Thr Leu Gln Gly Asp Pro Leu Arg Gly Thr Ala Asn Leu 
385                 390                 395                 400 
Ser Gly Gly Gly Gly Ser Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
                405                 410                 415     
Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
            420                 425                 430         
Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
        435                 440                 445             
Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
    450                 455                 460                 
Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
465                 470                 475                 480 
Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser 
                485                 490                 495     
Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
            500                 505                 510         
Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
        515                 520                 525             
Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
    530                 535                 540                 
Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
545                 550                 555                 560 
Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
                565                 570                 575     
His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
            580                 585                 590         
Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        595                 600             

<210> 30
<211> 595
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAR X2S

<400> 30
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Ser Arg Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          
Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              
Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  
Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      
Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         
Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             
Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu 
145                 150                 155                 160 
Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val 
                165                 170                 175     
Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys 
            180                 185                 190         
Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr 
        195                 200                 205             
Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys 
    210                 215                 220                 
Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala 
225                 230                 235                 240 
Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met 
                245                 250                 255     
Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Tyr Val Thr 
            260                 265                 270         
Val Ser Ser Gln Asp Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr His 
        275                 280                 285             
Thr Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Val Pro Pro Thr Leu 
    290                 295                 300                 
Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr 
305                 310                 315                 320 
Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu 
                325                 330                 335     
Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu 
            340                 345                 350         
Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val 
        355                 360                 365             
Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp 
    370                 375                 380                 
Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Lys Gly 
385                 390                 395                 400 
Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
                405                 410                 415     
Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
            420                 425                 430         
Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
        435                 440                 445             
Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
    450                 455                 460                 
Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
465                 470                 475                 480 
Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
                485                 490                 495     
Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
            500                 505                 510         
Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
        515                 520                 525             
Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
    530                 535                 540                 
Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
545                 550                 555                 560 
Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
                565                 570                 575     
Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
            580                 585                 590         
Pro Pro Arg 
        595 

<210> 31
<211> 689
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAR M

<400> 31
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Ser Arg Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          
Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              
Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  
Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      
Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         
Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             
Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu 
145                 150                 155                 160 
Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val 
                165                 170                 175     
Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys 
            180                 185                 190         
Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr 
        195                 200                 205             
Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys 
    210                 215                 220                 
Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala 
225                 230                 235                 240 
Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met 
                245                 250                 255     
Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Tyr Val Thr 
            260                 265                 270         
Val Ser Ser Gln Asp Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr His 
        275                 280                 285             
Thr Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Ala Lys Pro Ser Ala 
    290                 295                 300                 
Pro Val Val Ser Gly Pro Ala Ala Arg Ala Thr Pro Gln His Thr Val 
305                 310                 315                 320 
Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro Arg Asp Ile Thr Leu 
                325                 330                 335     
Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp Phe Gln Thr Asn Val 
            340                 345                 350         
Asp Pro Val Gly Glu Ser Val Ser Tyr Ser Ile His Ser Thr Ala Lys 
        355                 360                 365             
Val Val Leu Thr Arg Glu Asp Val His Ser Gln Val Ile Cys Glu Val 
    370                 375                 380                 
Ala His Val Thr Leu Gln Gly Asp Pro Leu Arg Gly Thr Ala Asn Leu 
385                 390                 395                 400 
Ser Glu Thr Ile Arg Val Pro Pro Thr Leu Glu Val Thr Gln Gln Pro 
                405                 410                 415     
Val Arg Ala Glu Asn Gln Val Asn Val Thr Cys Gln Val Arg Lys Phe 
            420                 425                 430         
Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu Glu Asn Gly Asn Val Ser 
        435                 440                 445             
Arg Thr Glu Thr Ala Ser Thr Val Thr Glu Asn Lys Asp Gly Thr Tyr 
    450                 455                 460                 
Asn Trp Met Ser Trp Leu Leu Val Asn Val Ser Ala His Arg Asp Asp 
465                 470                 475                 480 
Val Lys Leu Thr Cys Gln Val Glu His Asp Gly Gln Pro Ala Val Ser 
                485                 490                 495     
Lys Ser His Asp Leu Lys Val Ser Gly Gly Gly Gly Ser Phe Trp Val 
            500                 505                 510         
Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
        515                 520                 525             
Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
    530                 535                 540                 
His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
545                 550                 555                 560 
Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
                565                 570                 575     
Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
            580                 585                 590         
Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
        595                 600                 605             
Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
    610                 615                 620                 
Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
625                 630                 635                 640 
Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                645                 650                 655     
Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            660                 665                 670         
Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        675                 680                 685             
Arg 
    

<210> 32
<211> 701
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAR XM

<400> 32
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Ser Arg Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          
Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              
Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  
Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      
Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         
Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             
Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu 
145                 150                 155                 160 
Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val 
                165                 170                 175     
Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys 
            180                 185                 190         
Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr 
        195                 200                 205             
Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys 
    210                 215                 220                 
Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala 
225                 230                 235                 240 
Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met 
                245                 250                 255     
Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Tyr Val Thr 
            260                 265                 270         
Val Ser Ser Gln Asp Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr His 
        275                 280                 285             
Thr Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Ala Lys Pro Ser Ala 
    290                 295                 300                 
Pro Val Val Ser Gly Pro Ala Ala Arg Ala Thr Pro Gln His Thr Val 
305                 310                 315                 320 
Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro Arg Asp Ile Thr Leu 
                325                 330                 335     
Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp Phe Gln Thr Asn Val 
            340                 345                 350         
Asp Pro Val Gly Glu Ser Val Ser Tyr Ser Ile His Ser Thr Ala Lys 
        355                 360                 365             
Val Val Leu Thr Arg Glu Asp Val His Ser Gln Val Ile Cys Glu Val 
    370                 375                 380                 
Ala His Val Thr Leu Gln Gly Asp Pro Leu Arg Gly Thr Ala Asn Leu 
385                 390                 395                 400 
Ser Glu Thr Ile Arg Val Pro Pro Thr Leu Glu Val Thr Gln Gln Pro 
                405                 410                 415     
Val Arg Ala Glu Asn Gln Val Asn Val Thr Cys Gln Val Arg Lys Phe 
            420                 425                 430         
Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu Glu Asn Gly Asn Val Ser 
        435                 440                 445             
Arg Thr Glu Thr Ala Ser Thr Val Thr Glu Asn Lys Asp Gly Thr Tyr 
    450                 455                 460                 
Asn Trp Met Ser Trp Leu Leu Val Asn Val Ser Ala His Arg Asp Asp 
465                 470                 475                 480 
Val Lys Leu Thr Cys Gln Val Glu His Asp Gly Gln Pro Ala Val Ser 
                485                 490                 495     
Lys Ser His Asp Leu Lys Val Ser Lys Gly Lys His Leu Cys Pro Ser 
            500                 505                 510         
Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val 
        515                 520                 525             
Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
    530                 535                 540                 
Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
545                 550                 555                 560 
Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
                565                 570                 575     
Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys 
            580                 585                 590         
Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        595                 600                 605             
Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    610                 615                 620                 
Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
625                 630                 635                 640 
Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                645                 650                 655     
Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            660                 665                 670         
Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        675                 680                 685             
Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    690                 695                 700     

<210> 33
<211> 793
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAR L

<400> 33
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Ser Arg Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          
Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              
Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  
Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      
Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         
Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             
Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu 
145                 150                 155                 160 
Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val 
                165                 170                 175     
Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys 
            180                 185                 190         
Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr 
        195                 200                 205             
Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys 
    210                 215                 220                 
Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala 
225                 230                 235                 240 
Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met 
                245                 250                 255     
Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Tyr Val Thr 
            260                 265                 270         
Val Ser Ser Gln Asp Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr His 
        275                 280                 285             
Thr Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Val Pro Pro Thr Leu 
    290                 295                 300                 
Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr 
305                 310                 315                 320 
Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu 
                325                 330                 335     
Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu 
            340                 345                 350         
Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val 
        355                 360                 365             
Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp 
    370                 375                 380                 
Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Gly Gly 
385                 390                 395                 400 
Gly Gly Ser Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala 
                405                 410                 415     
Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly 
            420                 425                 430         
Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu 
        435                 440                 445             
Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser 
    450                 455                 460                 
Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val 
465                 470                 475                 480 
His Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp 
                485                 490                 495     
Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro 
            500                 505                 510         
Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn 
        515                 520                 525             
Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr 
    530                 535                 540                 
Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val 
545                 550                 555                 560 
Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val 
                565                 570                 575     
Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu 
            580                 585                 590         
His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser 
        595                 600                 605             
Gly Gly Gly Gly Ser Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
    610                 615                 620                 
Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
625                 630                 635                 640 
Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
                645                 650                 655     
Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            660                 665                 670         
Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
        675                 680                 685             
Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
    690                 695                 700                 
Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
705                 710                 715                 720 
Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
                725                 730                 735     
Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
            740                 745                 750         
Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
        755                 760                 765             
Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
    770                 775                 780                 
Leu His Met Gln Ala Leu Pro Pro Arg 
785                 790             

<210> 34
<211> 805
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAR XL

<400> 34
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Ser Arg Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          
Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              
Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  
Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      
Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         
Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             
Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu 
145                 150                 155                 160 
Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val 
                165                 170                 175     
Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys 
            180                 185                 190         
Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr 
        195                 200                 205             
Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys 
    210                 215                 220                 
Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala 
225                 230                 235                 240 
Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met 
                245                 250                 255     
Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Tyr Val Thr 
            260                 265                 270         
Val Ser Ser Gln Asp Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr His 
        275                 280                 285             
Thr Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Val Pro Pro Thr Leu 
    290                 295                 300                 
Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr 
305                 310                 315                 320 
Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu 
                325                 330                 335     
Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu 
            340                 345                 350         
Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val 
        355                 360                 365             
Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp 
    370                 375                 380                 
Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Gly Gly 
385                 390                 395                 400 
Gly Gly Ser Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala 
                405                 410                 415     
Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly 
            420                 425                 430         
Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu 
        435                 440                 445             
Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser 
    450                 455                 460                 
Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val 
465                 470                 475                 480 
His Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp 
                485                 490                 495     
Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro 
            500                 505                 510         
Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn 
        515                 520                 525             
Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr 
    530                 535                 540                 
Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val 
545                 550                 555                 560 
Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val 
                565                 570                 575     
Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu 
            580                 585                 590         
His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser 
        595                 600                 605             
Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys 
    610                 615                 620                 
Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
625                 630                 635                 640 
Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                645                 650                 655     
Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            660                 665                 670         
Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        675                 680                 685             
Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    690                 695                 700                 
Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
705                 710                 715                 720 
Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                725                 730                 735     
Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            740                 745                 750         
Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        755                 760                 765             
Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    770                 775                 780                 
Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
785                 790                 795                 800 
Ala Leu Pro Pro Arg 
                805 

<210> 35
<211> 129
<212> DNA
<213> Artificial Sequence


<220> 
<223> CAR spacer XS

<400> 35
agctacgtga ccgtgagcag ccaggacccc gccgagccca agagccccga caagacccac     60

acctgccccc cctgccccaa gggcaagcac ctgtgcccca gccccctgtt ccccggcccc    120

agcaagccc                                                            129


<210> 36
<211> 399
<212> DNA
<213> Artificial Sequence


<220> 
<223> CAR spacer 1S

<400> 36
agctacgtga ccgtgagcag ccaggacccc gccgagccca agagccccga caagacccac      60

acctgccccc cctgccccgg aggaggagga tctgccaagc ccagcgcccc cgtggtgagc     120

ggccccgccg ccagggccac cccccagcac accgtgagct tcacctgcga gagccacggc     180

ttcagcccca gggacatcac cctgaagtgg ttcaagaacg gcaacgagct gagcgacttc     240

cagaccaacg tggaccccgt gggcgagagc gtgagctaca gcatccacag caccgccaag     300

gtggtgctga ccagggagga cgtgcacagc caggtgatct gcgaggtggc ccacgtgacc     360

ctgcagggcg accccctgag gggcaccgcc aacctgagc                            399


<210> 37
<211> 390
<212> DNA
<213> Artificial Sequence


<220> 
<223> CAR spacer 2S

<400> 37
agctacgtga ccgtgagcag ccaggacccc gccgagccca agagccccga caagacccac      60

acctgccccc cctgccccgg aggaggagga tctgtgcccc ccaccctgga ggtgacccag     120

cagcccgtga gggccgagaa ccaggtgaac gtgacctgcc aggtgaggaa gttctacccc     180

cagaggctgc agctgacctg gctggagaac ggcaacgtga gcaggaccga gaccgccagc     240

accgtgaccg agaacaagga cggcacctac aactggatga gctggctgct ggtgaacgtg     300

agcgcccaca gggacgacgt gaagctgacc tgccaggtgg agcacgacgg ccagcccgcc     360

gtgagcaaga gccacgacct gaaggtgagc                                      390


<210> 38
<211> 465
<212> DNA
<213> Artificial Sequence


<220> 
<223> CAR spacer X1S

<400> 38
agctacgtga ccgtgagcag ccaggacccc gccgagccca agagccccga caagacccac      60

acctgccccc cctgccccgg aggaggagga tctgccaagc ccagcgcccc cgtggtgagc     120

ggccccgccg ccagggccac cccccagcac accgtgagct tcacctgcga gagccacggc     180

ttcagcccca gggacatcac cctgaagtgg ttcaagaacg gcaacgagct gagcgacttc     240

cagaccaacg tggaccccgt gggcgagagc gtgagctaca gcatccacag caccgccaag     300

gtggtgctga ccagggagga cgtgcacagc caggtgatct gcgaggtggc ccacgtgacc     360

ctgcagggcg accccctgag gggcaccgcc aacctgagcg gaggaggagg atctaagggc     420

aagcacctgt gccccagccc cctgttcccc ggccccagca agccc                     465


<210> 39
<211> 441
<212> DNA
<213> Artificial Sequence


<220> 
<223> CAR spacer X2S

<400> 39
agctacgtga ccgtgagcag ccaggacccc gccgagccca agagccccga caagacccac      60

acctgccccc cctgccccgg aggaggagga tctgtgcccc ccaccctgga ggtgacccag     120

cagcccgtga gggccgagaa ccaggtgaac gtgacctgcc aggtgaggaa gttctacccc     180

cagaggctgc agctgacctg gctggagaac ggcaacgtga gcaggaccga gaccgccagc     240

accgtgaccg agaacaagga cggcacctac aactggatga gctggctgct ggtgaacgtg     300

agcgcccaca gggacgacgt gaagctgacc tgccaggtgg agcacgacgg ccagcccgcc     360

gtgagcaaga gccacgacct gaaggtgagc aagggcaagc acctgtgccc cagccccctg     420

ttccccggcc ccagcaagcc c                                               441


<210> 40
<211> 707
<212> DNA
<213> Artificial Sequence


<220> 
<223> CAR spacer M

<400> 40
agctacgtga ccgtgagcag ccaggacccc gccgagccca agagccccga caagacccac      60

acctgccccc cctgccccgg aggaggagga tctgccaagc ccagcgcccc cgtggtgagc     120

ggccccgccg ccagggccac cccccagcac accgtgagct tcacctgcga gagccacggc     180

ttcagcccca gggacatcac cctgaagtgg ttcaagaacg gcaacgagct gagcgacttc     240

cagaccaacg tggaccccgt gggcgagagc gtgagctaca gcatccacag caccgccaag     300

gtggtgctga ccagggagga cgtgcacagc caggtgatct gcgaggtggc ccacgtgacc     360

ctgcagggcg accccctgag gggcaccgcc aacctgagcg agaccatcag ggtcccccca     420

ccctggaggt gacccagcag cccgtgaggg ccgagaacca ggtgaacgtg acctgccagg     480

tgaggaagtt ctacccccag aggctgcagc tgacctggct ggagaacggc aacgtgagca     540

ggaccgagac cgccagcacc gtgaccgaga acaaggacgg cacctacaac tggatgagct     600

ggctgctggt gaacgtgagc gcccacaggg acgacgtgaa gctgacctgc caggtggagc     660

acgacggcca gcccgccgtg agcaagagcc acgacctgaa ggtgagc                   707


<210> 41
<211> 759
<212> DNA
<213> Artificial Sequence


<220> 
<223> CAR spacer XM

<400> 41
agctacgtga ccgtgagcag ccaggacccc gccgagccca agagccccga caagacccac      60

acctgccccc cctgccccgg aggaggagga tctgccaagc ccagcgcccc cgtggtgagc     120

ggccccgccg ccagggccac cccccagcac accgtgagct tcacctgcga gagccacggc     180

ttcagcccca gggacatcac cctgaagtgg ttcaagaacg gcaacgagct gagcgacttc     240

cagaccaacg tggaccccgt gggcgagagc gtgagctaca gcatccacag caccgccaag     300

gtggtgctga ccagggagga cgtgcacagc caggtgatct gcgaggtggc ccacgtgacc     360

ctgcagggcg accccctgag gggcaccgcc aacctgagcg agaccatcag ggtgcccccc     420

accctggagg tgacccagca gcccgtgagg gccgagaacc aggtgaacgt gacctgccag     480

gtgaggaagt tctaccccca gaggctgcag ctgacctggc tggagaacgg caacgtgagc     540

aggaccgaga ccgccagcac cgtgaccgag aacaaggacg gcacctacaa ctggatgagc     600

tggctgctgg tgaacgtgag cgcccacagg gacgacgtga agctgacctg ccaggtggag     660

cacgacggcc agcccgccgt gagcaagagc cacgacctga aggtgagcaa gggcaagcac     720

ctgtgcccca gccccctgtt ccccggcccc agcaagccc                            759


<210> 42
<211> 1020
<212> DNA
<213> Artificial Sequence


<220> 
<223> CAR spacer L

<400> 42
agctacgtga ccgtgagcag ccaggacccc gccgagccca agagccccga caagacccac      60

acctgccccc cctgccccgg tggcggtgga agtgtgcccc ccaccctgga ggtgacccag     120

cagcccgtga gagccgagaa ccaggtgaac gtgacctgcc aggtgagaaa gttctacccc     180

cagagactgc agctgacctg gctggagaac ggcaacgtga gcagaaccga gaccgccagc     240

accgtgaccg agaacaagga cggcacctac aactggatga gctggctgct ggtgaacgtg     300

agcgcccaca gagacgacgt gaagctgacc tgccaggtgg agcacgacgg ccagcccgcc     360

gtgagcaaga gccacgacct gaaggtgagc ggcggaggcg ggagtgccaa gcccagcgcc     420

cccgtggtga gcggccccgc cgccagggcc accccccagc acaccgtgag cttcacctgc     480

gagagccacg gcttcagccc cagggacatc accctgaagt ggttcaagaa cggcaacgag     540

ctgagcgact tccagaccaa cgtggacccc gtgggcgaga gcgtgagcta cagcatccac     600

agcaccgcca aggtggtgct gaccagggag gacgtgcaca gccaggtgat ctgcgaggtg     660

gcccacgtga ccctgcaggg cgaccccctg aggggcaccg ccaacctgag cgagaccatc     720

agggtgcccc ccaccctgga ggtgacccag cagcccgtga gggccgagaa ccaggtgaac     780

gtgacctgcc aggtgaggaa gttctacccc cagaggctgc agctgacctg gctggagaac     840

ggcaacgtga gcaggaccga gaccgccagc accgtgaccg agaacaagga cggcacctac     900

aactggatga gctggctgct ggtgaacgtg agcgcccaca gggacgacgt gaagctgacc     960

tgccaggtgg agcacgacgg ccagcccgcc gtgagcaaga gccacgacct gaaggtgagc    1020


<210> 43
<211> 1071
<212> DNA
<213> Artificial Sequence


<220> 
<223> CAR spacer XL

<400> 43
agctacgtga ccgtgagcag ccaggacccc gccgagccca agagccccga caagacccac      60

acctgccccc cctgccccgg tggcggtgga agtgtgcccc ccaccctgga ggtgacccag     120

cagcccgtga gagccgagaa ccaggtgaac gtgacctgcc aggtgagaaa gttctacccc     180

cagagactgc agctgacctg gctggagaac ggcaacgtga gcagaaccga gaccgccagc     240

accgtgaccg agaacaagga cggcacctac aactggatga gctggctgct ggtgaacgtg     300

agcgcccaca gagacgacgt gaagctgacc tgccaggtgg agcacgacgg ccagcccgcc     360

gtgagcaaga gccacgacct gaaggtgagc ggcggaggcg ggagtgccaa gcccagcgcc     420

cccgtggtga gcggccccgc cgccagggcc accccccagc acaccgtgag cttcacctgc     480

gagagccacg gcttcagccc cagggacatc accctgaagt ggttcaagaa cggcaacgag     540

ctgagcgact tccagaccaa cgtggacccc gtgggcgaga gcgtgagcta cagcatccac     600

agcaccgcca aggtggtgct gaccagggag gacgtgcaca gccaggtgat ctgcgaggtg     660

gcccacgtga ccctgcaggg cgaccccctg aggggcaccg ccaacctgag cgagaccatc     720

agggtgcccc ccaccctgga ggtgacccag cagcccgtga gggccgagaa ccaggtgaac     780

gtgacctgcc aggtgaggaa gttctacccc cagaggctgc agctgacctg gctggagaac     840

ggcaacgtga gcaggaccga gaccgccagc accgtgaccg agaacaagga cggcacctac     900

aactggatga gctggctgct ggtgaacgtg agcgcccaca gggacgacgt gaagctgacc     960

tgccaggtgg agcacgacgg ccagcccgcc gtgagcaaga gccacgacct gaaggtgagc    1020

aagggcaagc acctgtgccc cagccccctg ttccccggcc ccagcaagcc c             1071


<210> 44
<211> 1476
<212> DNA
<213> Artificial Sequence


<220> 
<223> CAR XS

<400> 44
atggagttcg gcctgagctg gctgttcctg gtggccatcc tgaagggcgt gcagtgcagc      60

agggacatcc agatgaccca gaccaccagc agcctgagcg ccagcctggg cgacagggtg     120

accatcagct gcagggccag ccaggacatc agcaagtacc tgaactggta ccagcagaag     180

cccgacggca ccgtgaagct gctgatctac cacaccagca ggctgcacag cggcgtgccc     240

agcaggttca gcggcagcgg cagcggcacc gactacagcc tgaccatcag caacctggag     300

caggaggaca tcgccaccta cttctgccag cagggcaaca ccctgcccta caccttcggc     360

ggcggcacca agctggagct gaagaggggt ggtggtggtt ctggtggtgg tggttctggc     420

ggcggcggct ccggtggtgg tgggtccgag gtgcagctgc agcagagcgg ccccggcctg     480

gtggccccca gccagagcct gagcgtgacc tgcaccgtga gcggcgtgag cctgcccgac     540

tacggcgtga gctggatcag gcagcccccc aggaagggcc tggagtggct gggcgtgatc     600

tggggcagcg agaccaccta ctacaacagc gccctgaaga gcaggctgac catcatcaag     660

gacaacagca agagccaggt gttcctgaag atgaacagcc tgcagaccga cgacaccgcc     720

atctactact gcgccaagca ctactactac ggcggcagct acgccatgga ctactggggc     780

cagggcacca ccgtgaccgt gagcagctac gtgaccgtga gcagccagga ccccgccgag     840

cccaagagcc ccgacaagac ccacacctgc cccccctgcc ccaagggcaa gcacctgtgc     900

cccagccccc tgttccccgg ccccagcaag cccttctggg tgctggtggt ggtgggcggc     960

gtgctggcct gctacagcct gctggtgacc gtggccttca tcatcttctg ggtgaggagc    1020

aagaggagca ggctgctgca cagcgactac atgaacatga cccccaggag gcccggcccc    1080

accaggaagc actaccagcc ctacgccccc cccagggact tcgccgccta caggagcagg    1140

gtgaagttca gcaggagcgc cgacgccccc gcctaccagc agggccagaa ccagctgtac    1200

aacgagctga acctgggcag gagggaggag tacgacgtgc tggacaagag gaggggcagg    1260

gaccccgaga tgggcggcaa gcccaggagg aagaaccccc aggagggcct gtacaacgag    1320

ctgcagaagg acaagatggc cgaggcctac agcgagatcg gcatgaaggg cgagaggagg    1380

aggggcaagg gccacgacgg cctgtaccag ggcctgagca ccgccaccaa ggacacctac    1440

gacgccctgc acatgcaggc cctgcccccc aggtaa                              1476


<210> 45
<211> 1761
<212> DNA
<213> Artificial Sequence


<220> 
<223> CAR 1S

<400> 45
atggagttcg gcctgagctg gctgttcctg gtggccatcc tgaagggcgt gcagtgcagc      60

agggacatcc agatgaccca gaccaccagc agcctgagcg ccagcctggg cgacagggtg     120

accatcagct gcagggccag ccaggacatc agcaagtacc tgaactggta ccagcagaag     180

cccgacggca ccgtgaagct gctgatctac cacaccagca ggctgcacag cggcgtgccc     240

agcaggttca gcggcagcgg cagcggcacc gactacagcc tgaccatcag caacctggag     300

caggaggaca tcgccaccta cttctgccag cagggcaaca ccctgcccta caccttcggc     360

ggcggcacca agctggagct gaagaggggt ggtggtggtt ctggtggtgg tggttctggc     420

ggcggcggct ccggtggtgg tgggtccgag gtgcagctgc agcagagcgg ccccggcctg     480

gtggccccca gccagagcct gagcgtgacc tgcaccgtga gcggcgtgag cctgcccgac     540

tacggcgtga gctggatcag gcagcccccc aggaagggcc tggagtggct gggcgtgatc     600

tggggcagcg agaccaccta ctacaacagc gccctgaaga gcaggctgac catcatcaag     660

gacaacagca agagccaggt gttcctgaag atgaacagcc tgcagaccga cgacaccgcc     720

atctactact gcgccaagca ctactactac ggcggcagct acgccatgga ctactggggc     780

cagggcacca ccgtgaccgt gagcagctac gtgaccgtga gcagccagga ccccgccgag     840

cccaagagcc ccgacaagac ccacacctgc cccccctgcc ccggaggagg aggatctgcc     900

aagcccagcg cccccgtggt gagcggcccc gccgccaggg ccacccccca gcacaccgtg     960

agcttcacct gcgagagcca cggcttcagc cccagggaca tcaccctgaa gtggttcaag    1020

aacggcaacg agctgagcga cttccagacc aacgtggacc ccgtgggcga gagcgtgagc    1080

tacagcatcc acagcaccgc caaggtggtg ctgaccaggg aggacgtgca cagccaggtg    1140

atctgcgagg tggcccacgt gaccctgcag ggcgaccccc tgaggggcac cgccaacctg    1200

agcggtggtg gtggttcctt ctgggtgctg gtggtggtgg gcggcgtgct ggcctgctac    1260

agcctgctgg tgaccgtggc cttcatcatc ttctgggtga ggagcaagag gagcaggctg    1320

ctgcacagcg actacatgaa catgaccccc aggaggcccg gccccaccag gaagcactac    1380

cagccctacg ccccccccag ggacttcgcc gcctacagga gcagggtgaa gttcagcagg    1440

agcgccgacg cccccgccta ccagcagggc cagaaccagc tgtacaacga gctgaacctg    1500

ggcaggaggg aggagtacga cgtgctggac aagaggaggg gcagggaccc cgagatgggc    1560

ggcaagccca ggaggaagaa cccccaggag ggcctgtaca acgagctgca gaaggacaag    1620

atggccgagg cctacagcga gatcggcatg aagggcgaga ggaggagggg caagggccac    1680

gacggcctgt accagggcct gagcaccgcc accaaggaca cctacgacgc cctgcacatg    1740

caggccctgc cccccaggta a                                              1761


<210> 46
<211> 1752
<212> DNA
<213> Artificial Sequence


<220> 
<223> CAR 2S

<400> 46
atggagttcg gcctgagctg gctgttcctg gtggccatcc tgaagggcgt gcagtgcagc      60

agggacatcc agatgaccca gaccaccagc agcctgagcg ccagcctggg cgacagggtg     120

accatcagct gcagggccag ccaggacatc agcaagtacc tgaactggta ccagcagaag     180

cccgacggca ccgtgaagct gctgatctac cacaccagca ggctgcacag cggcgtgccc     240

agcaggttca gcggcagcgg cagcggcacc gactacagcc tgaccatcag caacctggag     300

caggaggaca tcgccaccta cttctgccag cagggcaaca ccctgcccta caccttcggc     360

ggcggcacca agctggagct gaagaggggt ggtggtggtt ctggtggtgg tggttctggc     420

ggcggcggct ccggtggtgg tgggtccgag gtgcagctgc agcagagcgg ccccggcctg     480

gtggccccca gccagagcct gagcgtgacc tgcaccgtga gcggcgtgag cctgcccgac     540

tacggcgtga gctggatcag gcagcccccc aggaagggcc tggagtggct gggcgtgatc     600

tggggcagcg agaccaccta ctacaacagc gccctgaaga gcaggctgac catcatcaag     660

gacaacagca agagccaggt gttcctgaag atgaacagcc tgcagaccga cgacaccgcc     720

atctactact gcgccaagca ctactactac ggcggcagct acgccatgga ctactggggc     780

cagggcacca ccgtgaccgt gagcagctac gtgaccgtga gcagccagga ccccgccgag     840

cccaagagcc ccgacaagac ccacacctgc cccccctgcc ccggaggagg aggatctgtg     900

ccccccaccc tggaggtgac ccagcagccc gtgagggccg agaaccaggt gaacgtgacc     960

tgccaggtga ggaagttcta cccccagagg ctgcagctga cctggctgga gaacggcaac    1020

gtgagcagga ccgagaccgc cagcaccgtg accgagaaca aggacggcac ctacaactgg    1080

atgagctggc tgctggtgaa cgtgagcgcc cacagggacg acgtgaagct gacctgccag    1140

gtggagcacg acggccagcc cgccgtgagc aagagccacg acctgaaggt gagcggtggt    1200

ggtggttcct tctgggtgct ggtggtggtg ggcggcgtgc tggcctgcta cagcctgctg    1260

gtgaccgtgg ccttcatcat cttctgggtg aggagcaaga ggagcaggct gctgcacagc    1320

gactacatga acatgacccc caggaggccc ggccccacca ggaagcacta ccagccctac    1380

gcccccccca gggacttcgc cgcctacagg agcagggtga agttcagcag gagcgccgac    1440

gcccccgcct accagcaggg ccagaaccag ctgtacaacg agctgaacct gggcaggagg    1500

gaggagtacg acgtgctgga caagaggagg ggcagggacc ccgagatggg cggcaagccc    1560

aggaggaaga acccccagga gggcctgtac aacgagctgc agaaggacaa gatggccgag    1620

gcctacagcg agatcggcat gaagggcgag aggaggaggg gcaagggcca cgacggcctg    1680

taccagggcc tgagcaccgc caccaaggac acctacgacg ccctgcacat gcaggccctg    1740

ccccccaggt aa                                                        1752


<210> 47
<211> 1812
<212> DNA
<213> Artificial Sequence


<220> 
<223> CAR X1S

<400> 47
atggagttcg gcctgagctg gctgttcctg gtggccatcc tgaagggcgt gcagtgcagc      60

agggacatcc agatgaccca gaccaccagc agcctgagcg ccagcctggg cgacagggtg     120

accatcagct gcagggccag ccaggacatc agcaagtacc tgaactggta ccagcagaag     180

cccgacggca ccgtgaagct gctgatctac cacaccagca ggctgcacag cggcgtgccc     240

agcaggttca gcggcagcgg cagcggcacc gactacagcc tgaccatcag caacctggag     300

caggaggaca tcgccaccta cttctgccag cagggcaaca ccctgcccta caccttcggc     360

ggcggcacca agctggagct gaagaggggt ggtggtggtt ctggtggtgg tggttctggc     420

ggcggcggct ccggtggtgg tgggtccgag gtgcagctgc agcagagcgg ccccggcctg     480

gtggccccca gccagagcct gagcgtgacc tgcaccgtga gcggcgtgag cctgcccgac     540

tacggcgtga gctggatcag gcagcccccc aggaagggcc tggagtggct gggcgtgatc     600

tggggcagcg agaccaccta ctacaacagc gccctgaaga gcaggctgac catcatcaag     660

gacaacagca agagccaggt gttcctgaag atgaacagcc tgcagaccga cgacaccgcc     720

atctactact gcgccaagca ctactactac ggcggcagct acgccatgga ctactggggc     780

cagggcacca ccgtgaccgt gagcagctac gtgaccgtga gcagccagga ccccgccgag     840

cccaagagcc ccgacaagac ccacacctgc cccccctgcc ccggaggagg aggatctgcc     900

aagcccagcg cccccgtggt gagcggcccc gccgccaggg ccacccccca gcacaccgtg     960

agcttcacct gcgagagcca cggcttcagc cccagggaca tcaccctgaa gtggttcaag    1020

aacggcaacg agctgagcga cttccagacc aacgtggacc ccgtgggcga gagcgtgagc    1080

tacagcatcc acagcaccgc caaggtggtg ctgaccaggg aggacgtgca cagccaggtg    1140

atctgcgagg tggcccacgt gaccctgcag ggcgaccccc tgaggggcac cgccaacctg    1200

agcggaggag gaggatctaa gggcaagcac ctgtgcccca gccccctgtt ccccggcccc    1260

agcaagccct tctgggtgct ggtggtggtg ggcggcgtgc tggcctgcta cagcctgctg    1320

gtgaccgtgg ccttcatcat cttctgggtg aggagcaaga ggagcaggct gctgcacagc    1380

gactacatga acatgacccc caggaggccc ggccccacca ggaagcacta ccagccctac    1440

gcccccccca gggacttcgc cgcctacagg agcagggtga agttcagcag gagcgccgac    1500

gcccccgcct accagcaggg ccagaaccag ctgtacaacg agctgaacct gggcaggagg    1560

gaggagtacg acgtgctgga caagaggagg ggcagggacc ccgagatggg cggcaagccc    1620

aggaggaaga acccccagga gggcctgtac aacgagctgc agaaggacaa gatggccgag    1680

gcctacagcg agatcggcat gaagggcgag aggaggaggg gcaagggcca cgacggcctg    1740

taccagggcc tgagcaccgc caccaaggac acctacgacg ccctgcacat gcaggccctg    1800

ccccccaggt aa                                                        1812


<210> 48
<211> 1788
<212> DNA
<213> Artificial Sequence


<220> 
<223> CAR X2S

<400> 48
atggagttcg gcctgagctg gctgttcctg gtggccatcc tgaagggcgt gcagtgcagc      60

agggacatcc agatgaccca gaccaccagc agcctgagcg ccagcctggg cgacagggtg     120

accatcagct gcagggccag ccaggacatc agcaagtacc tgaactggta ccagcagaag     180

cccgacggca ccgtgaagct gctgatctac cacaccagca ggctgcacag cggcgtgccc     240

agcaggttca gcggcagcgg cagcggcacc gactacagcc tgaccatcag caacctggag     300

caggaggaca tcgccaccta cttctgccag cagggcaaca ccctgcccta caccttcggc     360

ggcggcacca agctggagct gaagaggggt ggtggtggtt ctggtggtgg tggttctggc     420

ggcggcggct ccggtggtgg tgggtccgag gtgcagctgc agcagagcgg ccccggcctg     480

gtggccccca gccagagcct gagcgtgacc tgcaccgtga gcggcgtgag cctgcccgac     540

tacggcgtga gctggatcag gcagcccccc aggaagggcc tggagtggct gggcgtgatc     600

tggggcagcg agaccaccta ctacaacagc gccctgaaga gcaggctgac catcatcaag     660

gacaacagca agagccaggt gttcctgaag atgaacagcc tgcagaccga cgacaccgcc     720

atctactact gcgccaagca ctactactac ggcggcagct acgccatgga ctactggggc     780

cagggcacca ccgtgaccgt gagcagctac gtgaccgtga gcagccagga ccccgccgag     840

cccaagagcc ccgacaagac ccacacctgc cccccctgcc ccggaggagg aggatctgtg     900

ccccccaccc tggaggtgac ccagcagccc gtgagggccg agaaccaggt gaacgtgacc     960

tgccaggtga ggaagttcta cccccagagg ctgcagctga cctggctgga gaacggcaac    1020

gtgagcagga ccgagaccgc cagcaccgtg accgagaaca aggacggcac ctacaactgg    1080

atgagctggc tgctggtgaa cgtgagcgcc cacagggacg acgtgaagct gacctgccag    1140

gtggagcacg acggccagcc cgccgtgagc aagagccacg acctgaaggt gagcaagggc    1200

aagcacctgt gccccagccc cctgttcccc ggccccagca agcccttctg ggtgctggtg    1260

gtggtgggcg gcgtgctggc ctgctacagc ctgctggtga ccgtggcctt catcatcttc    1320

tgggtgagga gcaagaggag caggctgctg cacagcgact acatgaacat gacccccagg    1380

aggcccggcc ccaccaggaa gcactaccag ccctacgccc cccccaggga cttcgccgcc    1440

tacaggagca gggtgaagtt cagcaggagc gccgacgccc ccgcctacca gcagggccag    1500

aaccagctgt acaacgagct gaacctgggc aggagggagg agtacgacgt gctggacaag    1560

aggaggggca gggaccccga gatgggcggc aagcccagga ggaagaaccc ccaggagggc    1620

ctgtacaacg agctgcagaa ggacaagatg gccgaggcct acagcgagat cggcatgaag    1680

ggcgagagga ggaggggcaa gggccacgac ggcctgtacc agggcctgag caccgccacc    1740

aaggacacct acgacgccct gcacatgcag gccctgcccc ccaggtaa                 1788


<210> 49
<211> 2070
<212> DNA
<213> Artificial Sequence


<220> 
<223> CAR M

<400> 49
atggagttcg gcctgagctg gctgttcctg gtggccatcc tgaagggcgt gcagtgcagc      60

agggacatcc agatgaccca gaccaccagc agcctgagcg ccagcctggg cgacagggtg     120

accatcagct gcagggccag ccaggacatc agcaagtacc tgaactggta ccagcagaag     180

cccgacggca ccgtgaagct gctgatctac cacaccagca ggctgcacag cggcgtgccc     240

agcaggttca gcggcagcgg cagcggcacc gactacagcc tgaccatcag caacctggag     300

caggaggaca tcgccaccta cttctgccag cagggcaaca ccctgcccta caccttcggc     360

ggcggcacca agctggagct gaagaggggt ggtggtggtt ctggtggtgg tggttctggc     420

ggcggcggct ccggtggtgg tgggtccgag gtgcagctgc agcagagcgg ccccggcctg     480

gtggccccca gccagagcct gagcgtgacc tgcaccgtga gcggcgtgag cctgcccgac     540

tacggcgtga gctggatcag gcagcccccc aggaagggcc tggagtggct gggcgtgatc     600

tggggcagcg agaccaccta ctacaacagc gccctgaaga gcaggctgac catcatcaag     660

gacaacagca agagccaggt gttcctgaag atgaacagcc tgcagaccga cgacaccgcc     720

atctactact gcgccaagca ctactactac ggcggcagct acgccatgga ctactggggc     780

cagggcacca ccgtgaccgt gagcagctac gtgaccgtga gcagccagga ccccgccgag     840

cccaagagcc ccgacaagac ccacacctgc cccccctgcc ccggaggagg aggatctgcc     900

aagcccagcg cccccgtggt gagcggcccc gccgccaggg ccacccccca gcacaccgtg     960

agcttcacct gcgagagcca cggcttcagc cccagggaca tcaccctgaa gtggttcaag    1020

aacggcaacg agctgagcga cttccagacc aacgtggacc ccgtgggcga gagcgtgagc    1080

tacagcatcc acagcaccgc caaggtggtg ctgaccaggg aggacgtgca cagccaggtg    1140

atctgcgagg tggcccacgt gaccctgcag ggcgaccccc tgaggggcac cgccaacctg    1200

agcgagacca tcagggtgcc ccccaccctg gaggtgaccc agcagcccgt gagggccgag    1260

aaccaggtga acgtgacctg ccaggtgagg aagttctacc cccagaggct gcagctgacc    1320

tggctggaga acggcaacgt gagcaggacc gagaccgcca gcaccgtgac cgagaacaag    1380

gacggcacct acaactggat gagctggctg ctggtgaacg tgagcgccca cagggacgac    1440

gtgaagctga cctgccaggt ggagcacgac ggccagcccg ccgtgagcaa gagccacgac    1500

ctgaaggtga gcggtggtgg tggttccttc tgggtgctgg tggtggtggg cggcgtgctg    1560

gcctgctaca gcctgctggt gaccgtggcc ttcatcatct tctgggtgag gagcaagagg    1620

agcaggctgc tgcacagcga ctacatgaac atgaccccca ggaggcccgg ccccaccagg    1680

aagcactacc agccctacgc cccccccagg gacttcgccg cctacaggag cagggtgaag    1740

ttcagcagga gcgccgacgc ccccgcctac cagcagggcc agaaccagct gtacaacgag    1800

ctgaacctgg gcaggaggga ggagtacgac gtgctggaca agaggagggg cagggacccc    1860

gagatgggcg gcaagcccag gaggaagaac ccccaggagg gcctgtacaa cgagctgcag    1920

aaggacaaga tggccgaggc ctacagcgag atcggcatga agggcgagag gaggaggggc    1980

aagggccacg acggcctgta ccagggcctg agcaccgcca ccaaggacac ctacgacgcc    2040

ctgcacatgc aggccctgcc ccccaggtaa                                     2070


<210> 50
<211> 2106
<212> DNA
<213> Artificial Sequence


<220> 
<223> CAR XM

<400> 50
atggagttcg gcctgagctg gctgttcctg gtggccatcc tgaagggcgt gcagtgcagc      60

agggacatcc agatgaccca gaccaccagc agcctgagcg ccagcctggg cgacagggtg     120

accatcagct gcagggccag ccaggacatc agcaagtacc tgaactggta ccagcagaag     180

cccgacggca ccgtgaagct gctgatctac cacaccagca ggctgcacag cggcgtgccc     240

agcaggttca gcggcagcgg cagcggcacc gactacagcc tgaccatcag caacctggag     300

caggaggaca tcgccaccta cttctgccag cagggcaaca ccctgcccta caccttcggc     360

ggcggcacca agctggagct gaagaggggt ggtggtggtt ctggtggtgg tggttctggc     420

ggcggcggct ccggtggtgg tgggtccgag gtgcagctgc agcagagcgg ccccggcctg     480

gtggccccca gccagagcct gagcgtgacc tgcaccgtga gcggcgtgag cctgcccgac     540

tacggcgtga gctggatcag gcagcccccc aggaagggcc tggagtggct gggcgtgatc     600

tggggcagcg agaccaccta ctacaacagc gccctgaaga gcaggctgac catcatcaag     660

gacaacagca agagccaggt gttcctgaag atgaacagcc tgcagaccga cgacaccgcc     720

atctactact gcgccaagca ctactactac ggcggcagct acgccatgga ctactggggc     780

cagggcacca ccgtgaccgt gagcagctac gtgaccgtga gcagccagga ccccgccgag     840

cccaagagcc ccgacaagac ccacacctgc cccccctgcc ccggaggagg aggatctgcc     900

aagcccagcg cccccgtggt gagcggcccc gccgccaggg ccacccccca gcacaccgtg     960

agcttcacct gcgagagcca cggcttcagc cccagggaca tcaccctgaa gtggttcaag    1020

aacggcaacg agctgagcga cttccagacc aacgtggacc ccgtgggcga gagcgtgagc    1080

tacagcatcc acagcaccgc caaggtggtg ctgaccaggg aggacgtgca cagccaggtg    1140

atctgcgagg tggcccacgt gaccctgcag ggcgaccccc tgaggggcac cgccaacctg    1200

agcgagacca tcagggtgcc ccccaccctg gaggtgaccc agcagcccgt gagggccgag    1260

aaccaggtga acgtgacctg ccaggtgagg aagttctacc cccagaggct gcagctgacc    1320

tggctggaga acggcaacgt gagcaggacc gagaccgcca gcaccgtgac cgagaacaag    1380

gacggcacct acaactggat gagctggctg ctggtgaacg tgagcgccca cagggacgac    1440

gtgaagctga cctgccaggt ggagcacgac ggccagcccg ccgtgagcaa gagccacgac    1500

ctgaaggtga gcaagggcaa gcacctgtgc cccagccccc tgttccccgg ccccagcaag    1560

cccttctggg tgctggtggt ggtgggcggc gtgctggcct gctacagcct gctggtgacc    1620

gtggccttca tcatcttctg ggtgaggagc aagaggagca ggctgctgca cagcgactac    1680

atgaacatga cccccaggag gcccggcccc accaggaagc actaccagcc ctacgccccc    1740

cccagggact tcgccgccta caggagcagg gtgaagttca gcaggagcgc cgacgccccc    1800

gcctaccagc agggccagaa ccagctgtac aacgagctga acctgggcag gagggaggag    1860

tacgacgtgc tggacaagag gaggggcagg gaccccgaga tgggcggcaa gcccaggagg    1920

aagaaccccc aggagggcct gtacaacgag ctgcagaagg acaagatggc cgaggcctac    1980

agcgagatcg gcatgaaggg cgagaggagg aggggcaagg gccacgacgg cctgtaccag    2040

ggcctgagca ccgccaccaa ggacacctac gacgccctgc acatgcaggc cctgcccccc    2100

aggtaa                                                               2106


<210> 51
<211> 2382
<212> DNA
<213> Artificial Sequence


<220> 
<223> CAR L

<400> 51
atggagttcg gcctgagctg gctgttcctg gtggccatcc tgaagggcgt gcagtgcagc      60

agggacatcc agatgaccca gaccaccagc agcctgagcg ccagcctggg cgacagggtg     120

accatcagct gcagggccag ccaggacatc agcaagtacc tgaactggta ccagcagaag     180

cccgacggca ccgtgaagct gctgatctac cacaccagca ggctgcacag cggcgtgccc     240

agcaggttca gcggcagcgg cagcggcacc gactacagcc tgaccatcag caacctggag     300

caggaggaca tcgccaccta cttctgccag cagggcaaca ccctgcccta caccttcggc     360

ggcggcacca agctggagct gaagaggggc ggtggaggtt ccggcggtgg cggttccgga     420

ggcggtgggt caggaggtgg aggctccgag gtgcagctgc agcagagcgg ccccggcctg     480

gtggccccca gccagagcct gagcgtgacc tgcaccgtga gcggcgtgag cctgcccgac     540

tacggcgtga gctggatcag gcagcccccc aggaagggcc tggagtggct gggcgtgatc     600

tggggcagcg agaccaccta ctacaacagc gccctgaaga gcaggctgac catcatcaag     660

gacaacagca agagccaggt gttcctgaag atgaacagcc tgcagaccga cgacaccgcc     720

atctactact gcgccaagca ctactactac ggcggcagct acgccatgga ctactggggc     780

cagggcacca ccgtgaccgt gagcagctac gtgaccgtga gcagccagga ccccgccgag     840

cccaagagcc ccgacaagac ccacacctgc cccccctgcc ccggtggcgg tggaagtgtg     900

ccccccaccc tggaggtgac ccagcagccc gtgagagccg agaaccaggt gaacgtgacc     960

tgccaggtga gaaagttcta cccccagaga ctgcagctga cctggctgga gaacggcaac    1020

gtgagcagaa ccgagaccgc cagcaccgtg accgagaaca aggacggcac ctacaactgg    1080

atgagctggc tgctggtgaa cgtgagcgcc cacagagacg acgtgaagct gacctgccag    1140

gtggagcacg acggccagcc cgccgtgagc aagagccacg acctgaaggt gagcggcgga    1200

ggcgggagtg ccaagcccag cgcccccgtg gtgagcggcc ccgccgccag ggccaccccc    1260

cagcacaccg tgagcttcac ctgcgagagc cacggcttca gccccaggga catcaccctg    1320

aagtggttca agaacggcaa cgagctgagc gacttccaga ccaacgtgga ccccgtgggc    1380

gagagcgtga gctacagcat ccacagcacc gccaaggtgg tgctgaccag ggaggacgtg    1440

cacagccagg tgatctgcga ggtggcccac gtgaccctgc agggcgaccc cctgaggggc    1500

accgccaacc tgagcgagac catcagggtg ccccccaccc tggaggtgac ccagcagccc    1560

gtgagggccg agaaccaggt gaacgtgacc tgccaggtga ggaagttcta cccccagagg    1620

ctgcagctga cctggctgga gaacggcaac gtgagcagga ccgagaccgc cagcaccgtg    1680

accgagaaca aggacggcac ctacaactgg atgagctggc tgctggtgaa cgtgagcgcc    1740

cacagggacg acgtgaagct gacctgccag gtggagcacg acggccagcc cgccgtgagc    1800

aagagccacg acctgaaggt gagcggcggt ggcggcagct tctgggtgct ggtggtggtg    1860

ggcggcgtgc tggcctgcta cagcctgctg gtgaccgtgg ccttcatcat cttctgggtg    1920

aggagcaaga ggagcaggct gctgcacagc gactacatga acatgacccc caggaggccc    1980

ggccccacca ggaagcacta ccagccctac gcccccccca gggacttcgc cgcctacagg    2040

agcagggtga agttcagcag gagcgccgac gcccccgcct accagcaggg ccagaaccag    2100

ctgtacaacg agctgaacct gggcaggagg gaggagtacg acgtgctgga caagaggagg    2160

ggcagggacc ccgagatggg cggcaagccc aggaggaaga acccccagga gggcctgtac    2220

aacgagctgc agaaggacaa gatggccgag gcctacagcg agatcggcat gaagggcgag    2280

aggaggaggg gcaagggcca cgacggcctg taccagggcc tgagcaccgc caccaaggac    2340

acctacgacg ccctgcacat gcaggccctg ccccccaggt aa                       2382


<210> 52
<211> 2418
<212> DNA
<213> Artificial Sequence


<220> 
<223> CAR XL

<400> 52
atggagttcg gcctgagctg gctgttcctg gtggccatcc tgaagggcgt gcagtgcagc      60

agggacatcc agatgaccca gaccaccagc agcctgagcg ccagcctggg cgacagggtg     120

accatcagct gcagggccag ccaggacatc agcaagtacc tgaactggta ccagcagaag     180

cccgacggca ccgtgaagct gctgatctac cacaccagca ggctgcacag cggcgtgccc     240

agcaggttca gcggcagcgg cagcggcacc gactacagcc tgaccatcag caacctggag     300

caggaggaca tcgccaccta cttctgccag cagggcaaca ccctgcccta caccttcggc     360

ggcggcacca agctggagct gaagaggggc ggtggaggtt ccggcggtgg cggttccgga     420

ggcggtgggt caggaggtgg aggctccgag gtgcagctgc agcagagcgg ccccggcctg     480

gtggccccca gccagagcct gagcgtgacc tgcaccgtga gcggcgtgag cctgcccgac     540

tacggcgtga gctggatcag gcagcccccc aggaagggcc tggagtggct gggcgtgatc     600

tggggcagcg agaccaccta ctacaacagc gccctgaaga gcaggctgac catcatcaag     660

gacaacagca agagccaggt gttcctgaag atgaacagcc tgcagaccga cgacaccgcc     720

atctactact gcgccaagca ctactactac ggcggcagct acgccatgga ctactggggc     780

cagggcacca ccgtgaccgt gagcagctac gtgaccgtga gcagccagga ccccgccgag     840

cccaagagcc ccgacaagac ccacacctgc cccccctgcc ccggtggcgg tggaagtgtg     900

ccccccaccc tggaggtgac ccagcagccc gtgagagccg agaaccaggt gaacgtgacc     960

tgccaggtga gaaagttcta cccccagaga ctgcagctga cctggctgga gaacggcaac    1020

gtgagcagaa ccgagaccgc cagcaccgtg accgagaaca aggacggcac ctacaactgg    1080

atgagctggc tgctggtgaa cgtgagcgcc cacagagacg acgtgaagct gacctgccag    1140

gtggagcacg acggccagcc cgccgtgagc aagagccacg acctgaaggt gagcggcgga    1200

ggcgggagtg ccaagcccag cgcccccgtg gtgagcggcc ccgccgccag ggccaccccc    1260

cagcacaccg tgagcttcac ctgcgagagc cacggcttca gccccaggga catcaccctg    1320

aagtggttca agaacggcaa cgagctgagc gacttccaga ccaacgtgga ccccgtgggc    1380

gagagcgtga gctacagcat ccacagcacc gccaaggtgg tgctgaccag ggaggacgtg    1440

cacagccagg tgatctgcga ggtggcccac gtgaccctgc agggcgaccc cctgaggggc    1500

accgccaacc tgagcgagac catcagggtg ccccccaccc tggaggtgac ccagcagccc    1560

gtgagggccg agaaccaggt gaacgtgacc tgccaggtga ggaagttcta cccccagagg    1620

ctgcagctga cctggctgga gaacggcaac gtgagcagga ccgagaccgc cagcaccgtg    1680

accgagaaca aggacggcac ctacaactgg atgagctggc tgctggtgaa cgtgagcgcc    1740

cacagggacg acgtgaagct gacctgccag gtggagcacg acggccagcc cgccgtgagc    1800

aagagccacg acctgaaggt gagcaagggc aagcacctgt gccccagccc cctgttcccc    1860

ggccccagca agcccttctg ggtgctggtg gtggtgggcg gcgtgctggc ctgctacagc    1920

ctgctggtga ccgtggcctt catcatcttc tgggtgagga gcaagaggag caggctgctg    1980

cacagcgact acatgaacat gacccccagg aggcccggcc ccaccaggaa gcactaccag    2040

ccctacgccc cccccaggga cttcgccgcc tacaggagca gggtgaagtt cagcaggagc    2100

gccgacgccc ccgcctacca gcagggccag aaccagctgt acaacgagct gaacctgggc    2160

aggagggagg agtacgacgt gctggacaag aggaggggca gggaccccga gatgggcggc    2220

aagcccagga ggaagaaccc ccaggagggc ctgtacaacg agctgcagaa ggacaagatg    2280

gccgaggcct acagcgagat cggcatgaag ggcgagagga ggaggggcaa gggccacgac    2340

ggcctgtacc agggcctgag caccgccacc aaggacacct acgacgccct gcacatgcag    2400

gccctgcccc ccaggtaa                                                  2418


<210> 53
<211> 247
<212> PRT
<213> Homo sapiens


<220> 
<223> HER-2 scFv

<400> 53
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
    130                 135                 140                 
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
145                 150                 155                 160 
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                165                 170                 175     
Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
            180                 185                 190         
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
        195                 200                 205             
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
    210                 215                 220                 
Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
225                 230                 235                 240 
Gly Thr Leu Val Thr Val Ser 
                245         

<210> 54
<211> 689
<212> PRT
<213> Artificial Sequence


<220> 
<223> Her2 CAR M

<400> 54
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Ser Arg Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              
Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  
Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro 
65                  70                  75                  80  
Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His 
            100                 105                 110         
Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             
Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 
Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     
Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         
Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg 
        195                 200                 205             
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser 
    210                 215                 220                 
Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 
Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met 
                245                 250                 255     
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Tyr Val Thr 
            260                 265                 270         
Val Ser Ser Gln Asp Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr His 
        275                 280                 285             
Thr Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Ala Lys Pro Ser Ala 
    290                 295                 300                 
Pro Val Val Ser Gly Pro Ala Ala Arg Ala Thr Pro Gln His Thr Val 
305                 310                 315                 320 
Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro Arg Asp Ile Thr Leu 
                325                 330                 335     
Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp Phe Gln Thr Asn Val 
            340                 345                 350         
Asp Pro Val Gly Glu Ser Val Ser Tyr Ser Ile His Ser Thr Ala Lys 
        355                 360                 365             
Val Val Leu Thr Arg Glu Asp Val His Ser Gln Val Ile Cys Glu Val 
    370                 375                 380                 
Ala His Val Thr Leu Gln Gly Asp Pro Leu Arg Gly Thr Ala Asn Leu 
385                 390                 395                 400 
Ser Glu Thr Ile Arg Val Pro Pro Thr Leu Glu Val Thr Gln Gln Pro 
                405                 410                 415     
Val Arg Ala Glu Asn Gln Val Asn Val Thr Cys Gln Val Arg Lys Phe 
            420                 425                 430         
Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu Glu Asn Gly Asn Val Ser 
        435                 440                 445             
Arg Thr Glu Thr Ala Ser Thr Val Thr Glu Asn Lys Asp Gly Thr Tyr 
    450                 455                 460                 
Asn Trp Met Ser Trp Leu Leu Val Asn Val Ser Ala His Arg Asp Asp 
465                 470                 475                 480 
Val Lys Leu Thr Cys Gln Val Glu His Asp Gly Gln Pro Ala Val Ser 
                485                 490                 495     
Lys Ser His Asp Leu Lys Val Ser Gly Gly Gly Gly Ser Phe Trp Val 
            500                 505                 510         
Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
        515                 520                 525             
Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
    530                 535                 540                 
His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
545                 550                 555                 560 
Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
                565                 570                 575     
Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
            580                 585                 590         
Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
        595                 600                 605             
Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
    610                 615                 620                 
Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
625                 630                 635                 640 
Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                645                 650                 655     
Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            660                 665                 670         
Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        675                 680                 685             
Arg 
    

<210> 55
<211> 2070
<212> DNA
<213> Artificial Sequence


<220> 
<223> HER-2 CAR M

<400> 55
atggagttcg gcctgagctg gctgttcctg gtggccatcc tgaagggcgt gcagtgcagc      60

agggacatcc agatgaccca gagccccagc agcctgagcg ccagcgtggg cgacagggtg     120

accatcacct gcagggccag ccaggacgtg aacaccgccg tggcctggta ccagcagaag     180

cccggcaagg cccccaagct gctgatctac agcgccagct tcctgtacag cggcgtgccc     240

agcaggttca gcggcagcag gagcggcacc gacttcaccc tgaccatcag cagcctgcag     300

cccgaggact tcgccaccta ctactgccag cagcactaca ccaccccccc caccttcggc     360

cagggcacca aggtggagat caagaggggc ggtggaggtt ccggcggtgg cggttccgga     420

ggcggtgggt caggaggtgg aggctccgag gtgcagctgg tggagagcgg cggcggcctg     480

gtgcagcccg gcggcagcct gaggctgagc tgcgccgcca gcggcttcaa catcaaggac     540

acctacatcc actgggtgag gcaggccccc ggcaagggcc tggagtgggt ggccaggatc     600

taccccacca acggctacac caggtacgcc gacagcgtga agggcaggtt caccatcagc     660

gccgacacca gcaagaacac cgcctacctg cagatgaaca gcctgagggc cgaggacacc     720

gccgtgtact actgcagcag gtggggcggc gacggcttct acgccatgga ctactggggc     780

cagggcaccc tggtgaccgt gagcagctac gtgaccgtga gcagccagga ccccgccgag     840

cccaagagcc ccgacaagac ccacacctgc cccccctgcc ccggtggcgg tggaagtgcc     900

aagcccagcg cccccgtggt gagcggcccc gccgccaggg ccacccccca gcacaccgtg     960

agcttcacct gcgagagcca cggcttcagc cccagggaca tcaccctgaa gtggttcaag    1020

aacggcaacg agctgagcga cttccagacc aacgtggacc ccgtgggcga gagcgtgagc    1080

tacagcatcc acagcaccgc caaggtggtg ctgaccaggg aggacgtgca cagccaggtg    1140

atctgcgagg tggcccacgt gaccctgcag ggcgaccccc tgaggggcac cgccaacctg    1200

agcgagacca tcagggtgcc ccccaccctg gaggtgaccc agcagcccgt gagggccgag    1260

aaccaggtga acgtgacctg ccaggtgagg aagttctacc cccagaggct gcagctgacc    1320

tggctggaga acggcaacgt gagcaggacc gagaccgcca gcaccgtgac cgagaacaag    1380

gacggcacct acaactggat gagctggctg ctggtgaacg tgagcgccca cagggacgac    1440

gtgaagctga cctgccaggt ggagcacgac ggccagcccg ccgtgagcaa gagccacgac    1500

ctgaaggtga gcggcggtgg cggcagcttc tgggtgctgg tggtggtggg cggcgtgctg    1560

gcctgctaca gcctgctggt gaccgtggcc ttcatcatct tctgggtgag gagcaagagg    1620

agcaggctgc tgcacagcga ctacatgaac atgaccccca ggaggcccgg ccccaccagg    1680

aagcactacc agccctacgc cccccccagg gacttcgccg cctacaggag cagggtgaag    1740

ttcagcagga gcgccgacgc ccccgcctac cagcagggcc agaaccagct gtacaacgag    1800

ctgaacctgg gcaggaggga ggagtacgac gtgctggaca agaggagggg cagggacccc    1860

gagatgggcg gcaagcccag gaggaagaac ccccaggagg gcctgtacaa cgagctgcag    1920

aaggacaaga tggccgaggc ctacagcgag atcggcatga agggcgagag gaggaggggc    1980

aagggccacg acggcctgta ccagggcctg agcaccgcca ccaaggacac ctacgacgcc    2040

ctgcacatgc aggccctgcc ccccaggtaa                                     2070


<210> 56
<211> 220
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAR spacer M1

<400> 56
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gly Gly Gly 
1               5                   10                  15      
Ser Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala 
            20                  25                  30          
Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser 
        35                  40                  45              
Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser 
    50                  55                  60                  
Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser 
65                  70                  75                  80  
Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser 
                85                  90                  95      
Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu 
            100                 105                 110         
Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu 
        115                 120                 125             
Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr 
    130                 135                 140                 
Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu 
145                 150                 155                 160 
Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu 
                165                 170                 175     
Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val 
            180                 185                 190         
Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp 
        195                 200                 205             
Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys 
    210                 215                 220 

<210> 57
<211> 239
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAR spacer XM2

<400> 57
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gly Gly Gly 
1               5                   10                  15      
Ser Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala 
            20                  25                  30          
Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser 
        35                  40                  45              
Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser 
    50                  55                  60                  
Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser 
65                  70                  75                  80  
Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser 
                85                  90                  95      
Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu 
            100                 105                 110         
Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu 
        115                 120                 125             
Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr 
    130                 135                 140                 
Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu 
145                 150                 155                 160 
Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu 
                165                 170                 175     
Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val 
            180                 185                 190         
Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp 
        195                 200                 205             
Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Lys Gly 
    210                 215                 220                 
Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro 
225                 230                 235                 

<210> 58
<211> 256
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAR spacer XM3

<400> 58
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gly Gly Gly 
1               5                   10                  15      
Ser Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala 
            20                  25                  30          
Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser 
        35                  40                  45              
Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser 
    50                  55                  60                  
Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser 
65                  70                  75                  80  
Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser 
                85                  90                  95      
Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu 
            100                 105                 110         
Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Glu Ser Lys Tyr Gly 
        115                 120                 125             
Pro Pro Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Val Pro Pro Thr 
    130                 135                 140                 
Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val 
145                 150                 155                 160 
Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp 
                165                 170                 175     
Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr 
            180                 185                 190         
Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn 
        195                 200                 205             
Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His 
    210                 215                 220                 
Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Lys 
225                 230                 235                 240 
Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro 
                245                 250                 255     



<210> 59
<211> 256
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAR spacer M4

<400> 59
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gly Gly Gly 
1               5                   10                  15      
Ser Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala 
            20                  25                  30          
Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser 
        35                  40                  45              
Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser 
    50                  55                  60                  
Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser 
65                  70                  75                  80  
Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser 
                85                  90                  95      
Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu 
            100                 105                 110         
Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Glu Ser Lys Tyr Gly 
        115                 120                 125             
Pro Pro Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Val Pro Pro Thr 
    130                 135                 140                 
Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val 
145                 150                 155                 160 
Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp 
                165                 170                 175     
Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr 
            180                 185                 190         
Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn 
        195                 200                 205             
Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His 
    210                 215                 220                 
Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Glu 
225                 230                 235                 240 
Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser 
                245                 250                 255     



<210> 60
<211> 133
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAR spacer 2S5

<400> 60
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gly Gly Gly 
1               5                   10                  15      
Ser Val Pro Pro Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu 
            20                  25                  30          
Asn Gln Val Asn Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg 
        35                  40                  45              
Leu Gln Leu Thr Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr 
    50                  55                  60                  
Ala Ser Thr Val Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser 
65                  70                  75                  80  
Trp Leu Leu Val Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr 
                85                  90                  95      
Cys Gln Val Glu His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp 
            100                 105                 110         
Leu Lys Val Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
        115                 120                 125             
Gly Gly Gly Gly Ser 
    130             

<210> 61
<211> 208
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAR spacer M6

<400> 61
Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala Thr Pro Gln 
1               5                   10                  15      
His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro Arg Asp 
            20                  25                  30          
Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp Phe Gln 
        35                  40                  45              
Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser Ile His Ser 
    50                  55                  60                  
Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser Gln Val Ile 
65                  70                  75                  80  
Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu Arg Gly Thr 
                85                  90                  95      
Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu Glu Val Thr 
            100                 105                 110         
Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr Cys Gln Val 
        115                 120                 125             
Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu Glu Asn Gly 
    130                 135                 140                 
Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu Asn Lys Asp 
145                 150                 155                 160 
Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val Ser Ala His 
                165                 170                 175     
Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp Gly Gln Pro 
            180                 185                 190         
Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Gly Gly Gly Gly Ser 
        195                 200                 205             



<210> 62
<211> 676
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAR M1

<400> 62
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Ser Arg Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          
Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              
Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  
Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      
Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         
Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             
Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu 
145                 150                 155                 160 
Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val 
                165                 170                 175     
Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys 
            180                 185                 190         
Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr 
        195                 200                 205             
Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys 
    210                 215                 220                 
Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala 
225                 230                 235                 240 
Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met 
                245                 250                 255     
Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Glu Ser Lys 
            260                 265                 270         
Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Ala Lys 
        275                 280                 285             
Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala Thr Pro Gln 
    290                 295                 300                 
His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro Arg Asp 
305                 310                 315                 320 
Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp Phe Gln 
                325                 330                 335     
Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser Ile His Ser 
            340                 345                 350         
Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser Gln Val Ile 
        355                 360                 365             
Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu Arg Gly Thr 
    370                 375                 380                 
Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu Glu Val Thr 
385                 390                 395                 400 
Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr Cys Gln Val 
                405                 410                 415     
Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu Glu Asn Gly 
            420                 425                 430         
Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu Asn Lys Asp 
        435                 440                 445             
Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val Ser Ala His 
    450                 455                 460                 
Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp Gly Gln Pro 
465                 470                 475                 480 
Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Gly Gly Gly Gly Ser 
                485                 490                 495     
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
            500                 505                 510         
Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
        515                 520                 525             
Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
    530                 535                 540                 
Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
545                 550                 555                 560 
Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                565                 570                 575     
Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            580                 585                 590         
Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        595                 600                 605             
Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    610                 615                 620                 
Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
625                 630                 635                 640 
Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                645                 650                 655     
Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            660                 665                 670         
Leu Pro Pro Arg 
        675     

<210> 63
<211> 688
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAR XM2

<400> 63
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Ser Arg Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          
Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              
Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  
Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      
Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         
Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             
Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu 
145                 150                 155                 160 
Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val 
                165                 170                 175     
Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys 
            180                 185                 190         
Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr 
        195                 200                 205             
Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys 
    210                 215                 220                 
Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala 
225                 230                 235                 240 
Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met 
                245                 250                 255     
Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Glu Ser Lys 
            260                 265                 270         
Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Ala Lys 
        275                 280                 285             
Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala Thr Pro Gln 
    290                 295                 300                 
His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro Arg Asp 
305                 310                 315                 320 
Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp Phe Gln 
                325                 330                 335     
Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser Ile His Ser 
            340                 345                 350         
Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser Gln Val Ile 
        355                 360                 365             
Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu Arg Gly Thr 
    370                 375                 380                 
Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu Glu Val Thr 
385                 390                 395                 400 
Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr Cys Gln Val 
                405                 410                 415     
Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu Glu Asn Gly 
            420                 425                 430         
Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu Asn Lys Asp 
        435                 440                 445             
Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val Ser Ala His 
    450                 455                 460                 
Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp Gly Gln Pro 
465                 470                 475                 480 
Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Lys Gly Lys His Leu 
                485                 490                 495     
Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
            500                 505                 510         
Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
        515                 520                 525             
Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
    530                 535                 540                 
Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
545                 550                 555                 560 
His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
                565                 570                 575     
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
            580                 585                 590         
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        595                 600                 605             
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    610                 615                 620                 
Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
625                 630                 635                 640 
Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                645                 650                 655     
Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            660                 665                 670         
Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        675                 680                 685             



<210> 64
<211> 705
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAR XM3

<400> 64
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Ser Arg Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          
Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              
Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  
Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      
Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         
Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             
Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu 
145                 150                 155                 160 
Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val 
                165                 170                 175     
Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys 
            180                 185                 190         
Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr 
        195                 200                 205             
Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys 
    210                 215                 220                 
Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala 
225                 230                 235                 240 
Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met 
                245                 250                 255     
Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Glu Ser Lys 
            260                 265                 270         
Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Ala Lys 
        275                 280                 285             
Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala Thr Pro Gln 
    290                 295                 300                 
His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro Arg Asp 
305                 310                 315                 320 
Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp Phe Gln 
                325                 330                 335     
Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser Ile His Ser 
            340                 345                 350         
Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser Gln Val Ile 
        355                 360                 365             
Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu Arg Gly Thr 
    370                 375                 380                 
Ala Asn Leu Ser Glu Thr Ile Arg Glu Ser Lys Tyr Gly Pro Pro Cys 
385                 390                 395                 400 
Pro Pro Cys Pro Gly Gly Gly Gly Ser Val Pro Pro Thr Leu Glu Val 
                405                 410                 415     
Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr Cys Gln 
            420                 425                 430         
Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu Glu Asn 
        435                 440                 445             
Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu Asn Lys 
    450                 455                 460                 
Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val Ser Ala 
465                 470                 475                 480 
His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp Gly Gln 
                485                 490                 495     
Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Lys Gly Lys His 
            500                 505                 510         
Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val 
        515                 520                 525             
Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
    530                 535                 540                 
Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
545                 550                 555                 560 
His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
                565                 570                 575     
Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
            580                 585                 590         
Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
        595                 600                 605             
Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
    610                 615                 620                 
Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
625                 630                 635                 640 
Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
                645                 650                 655     
Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
            660                 665                 670         
Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
        675                 680                 685             
Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
    690                 695                 700                 
Arg 
705 

<210> 65
<211> 705
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAR M4

<400> 65
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Ser Arg Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          
Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              
Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  
Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      
Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         
Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             
Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu 
145                 150                 155                 160 
Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val 
                165                 170                 175     
Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys 
            180                 185                 190         
Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr 
        195                 200                 205             
Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys 
    210                 215                 220                 
Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala 
225                 230                 235                 240 
Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met 
                245                 250                 255     
Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Glu Ser Lys 
            260                 265                 270         
Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Ala Lys 
        275                 280                 285             
Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala Thr Pro Gln 
    290                 295                 300                 
His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro Arg Asp 
305                 310                 315                 320 
Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp Phe Gln 
                325                 330                 335     
Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser Ile His Ser 
            340                 345                 350         
Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser Gln Val Ile 
        355                 360                 365             
Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu Arg Gly Thr 
    370                 375                 380                 
Ala Asn Leu Ser Glu Thr Ile Arg Glu Ser Lys Tyr Gly Pro Pro Cys 
385                 390                 395                 400 
Pro Pro Cys Pro Gly Gly Gly Gly Ser Val Pro Pro Thr Leu Glu Val 
                405                 410                 415     
Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr Cys Gln 
            420                 425                 430         
Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu Glu Asn 
        435                 440                 445             
Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu Asn Lys 
    450                 455                 460                 
Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val Ser Ala 
465                 470                 475                 480 
His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp Gly Gln 
                485                 490                 495     
Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Glu Ser Lys Tyr 
            500                 505                 510         
Gly Pro Pro Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Phe Trp Val 
        515                 520                 525             
Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
    530                 535                 540                 
Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
545                 550                 555                 560 
His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
                565                 570                 575     
Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
            580                 585                 590         
Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
        595                 600                 605             
Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
    610                 615                 620                 
Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
625                 630                 635                 640 
Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
                645                 650                 655     
Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
            660                 665                 670         
Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
        675                 680                 685             
Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
    690                 695                 700                 
Arg 
705 

<210> 66
<211> 582
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAR 2S5

<400> 66
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Ser Arg Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          
Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              
Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  
Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      
Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         
Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             
Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu 
145                 150                 155                 160 
Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val 
                165                 170                 175     
Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys 
            180                 185                 190         
Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr 
        195                 200                 205             
Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys 
    210                 215                 220                 
Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala 
225                 230                 235                 240 
Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met 
                245                 250                 255     
Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Glu Ser Lys 
            260                 265                 270         
Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Val Pro 
        275                 280                 285             
Pro Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val 
    290                 295                 300                 
Asn Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu 
305                 310                 315                 320 
Thr Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr 
                325                 330                 335     
Val Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu 
            340                 345                 350         
Val Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val 
        355                 360                 365             
Glu His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val 
    370                 375                 380                 
Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gly Gly 
385                 390                 395                 400 
Gly Ser Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
                405                 410                 415     
Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys 
            420                 425                 430         
Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
        435                 440                 445             
Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
    450                 455                 460                 
Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
465                 470                 475                 480 
Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
                485                 490                 495     
Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
            500                 505                 510         
Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
        515                 520                 525             
Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
    530                 535                 540                 
Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
545                 550                 555                 560 
Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
                565                 570                 575     
Gln Ala Leu Pro Pro Arg 
            580         

<210> 67
<211> 664
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAR M6

<400> 67
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Ser Arg Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          
Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              
Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  
Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      
Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         
Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             
Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu 
145                 150                 155                 160 
Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val 
                165                 170                 175     
Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys 
            180                 185                 190         
Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr 
        195                 200                 205             
Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys 
    210                 215                 220                 
Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala 
225                 230                 235                 240 
Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met 
                245                 250                 255     
Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
            260                 265                 270         
Gly Ser Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg 
        275                 280                 285             
Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe 
    290                 295                 300                 
Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu 
305                 310                 315                 320 
Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr 
                325                 330                 335     
Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His 
            340                 345                 350         
Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro 
        355                 360                 365             
Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr 
    370                 375                 380                 
Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val 
385                 390                 395                 400 
Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp 
                405                 410                 415     
Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr 
            420                 425                 430         
Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn 
        435                 440                 445             
Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His 
    450                 455                 460                 
Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Gly 
465                 470                 475                 480 
Gly Gly Gly Ser Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
                485                 490                 495     
Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
            500                 505                 510         
Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
        515                 520                 525             
Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
    530                 535                 540                 
Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala 
545                 550                 555                 560 
Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
                565                 570                 575     
Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
            580                 585                 590         
Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
        595                 600                 605             
Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
    610                 615                 620                 
Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
625                 630                 635                 640 
Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
                645                 650                 655     
His Met Gln Ala Leu Pro Pro Arg 
            660                 

<210> 68
<211> 666
<212> DNA
<213> Artificial Sequence


<220> 
<223> CAR spacer M1

<400> 68
gagagcaagt acggcccccc ctgccccccc tgccccggtg gcggtggaag tgccaagccc      60

agcgcccccg tggtgagcgg ccccgccgcc agggccaccc cccagcacac cgtgagcttc     120

acctgcgaga gccacggctt cagccccagg gacatcaccc tgaagtggtt caagaacggc     180

aacgagctga gcgacttcca gaccaacgtg gaccccgtgg gcgagagcgt gagctacagc     240

atccacagca ccgccaaggt ggtgctgacc agggaggacg tgcacagcca ggtgatctgc     300

gaggtggccc acgtgaccct gcagggcgac cccctgaggg gcaccgccaa cctgagcgag     360

accatcaggg tgccccccac cctggaggtg acccagcagc ccgtgagggc cgagaaccag     420

gtgaacgtga cctgccaggt gaggaagttc tacccccaga ggctgcagct gacctggctg     480

gagaacggca acgtgagcag gaccgagacc gccagcaccg tgaccgagaa caaggacggc     540

acctacaact ggatgagctg gctgctggtg aacgtgagcg cccacaggga cgacgtgaag     600

ctgacctgcc aggtggagca cgacggccag cccgccgtga gcaagagcca cgacctgaag     660

gtgagc                                                                666


<210> 69
<211> 717
<212> DNA
<213> Artificial Sequence


<220> 
<223> CAR spacer XM2

<400> 69
gagagcaagt acggcccccc ctgccccccc tgccccggtg gcggtggaag tgccaagccc      60

agcgcccccg tggtgagcgg ccccgccgcc agggccaccc cccagcacac cgtgagcttc     120

acctgcgaga gccacggctt cagccccagg gacatcaccc tgaagtggtt caagaacggc     180

aacgagctga gcgacttcca gaccaacgtg gaccccgtgg gcgagagcgt gagctacagc     240

atccacagca ccgccaaggt ggtgctgacc agggaggacg tgcacagcca ggtgatctgc     300

gaggtggccc acgtgaccct gcagggcgac cccctgaggg gcaccgccaa cctgagcgag     360

accatcaggg tgccccccac cctggaggtg acccagcagc ccgtgagggc cgagaaccag     420

gtgaacgtga cctgccaggt gaggaagttc tacccccaga ggctgcagct gacctggctg     480

gagaacggca acgtgagcag gaccgagacc gccagcaccg tgaccgagaa caaggacggc     540

acctacaact ggatgagctg gctgctggtg aacgtgagcg cccacaggga cgacgtgaag     600

ctgacctgcc aggtggagca cgacggccag cccgccgtga gcaagagcca cgacctgaag     660

gtgagcaagg gcaagcacct gtgccccagc cccctgttcc ccggccccag caagccc        717


<210> 70
<211> 768
<212> DNA
<213> Artificial Sequence


<220> 
<223> CAR spacer XM3

<400> 70
gagagcaagt acggcccccc ctgccccccc tgccccggtg gcggtggaag tgccaagccc      60

agcgcccccg tggtgagcgg ccccgccgcc agggccaccc cccagcacac cgtgagcttc     120

acctgcgaga gccacggctt cagccccagg gacatcaccc tgaagtggtt caagaacggc     180

aacgagctga gcgacttcca gaccaacgtg gaccccgtgg gcgagagcgt gagctacagc     240

atccacagca ccgccaaggt ggtgctgacc agggaggacg tgcacagcca ggtgatctgc     300

gaggtggccc acgtgaccct gcagggcgac cccctgaggg gcaccgccaa cctgagcgag     360

accatcaggg aatccaaata cggaccacca tgcccaccat gcccaggcgg aggcggtagt     420

gtgcccccca ccctggaggt gacccagcag cccgtgaggg ccgagaacca ggtgaacgtg     480

acctgccagg tgaggaagtt ctacccccag aggctgcagc tgacctggct ggagaacggc     540

aacgtgagca ggaccgagac cgccagcacc gtgaccgaga acaaggacgg cacctacaac     600

tggatgagct ggctgctggt gaacgtgagc gcccacaggg acgacgtgaa gctgacctgc     660

caggtggagc acgacggcca gcccgccgtg agcaagagcc acgacctgaa ggtgagcaag     720

ggcaagcacc tgtgccccag ccccctgttc cccggcccca gcaagccc                  768


<210> 71
<211> 768
<212> DNA
<213> Artificial Sequence


<220> 
<223> CAR spacer M4

<400> 71
gagagcaagt acggcccccc ctgccccccc tgccccggtg gcggtggaag tgccaagccc      60

agcgcccccg tggtgagcgg ccccgccgcc agggccaccc cccagcacac cgtgagcttc     120

acctgcgaga gccacggctt cagccccagg gacatcaccc tgaagtggtt caagaacggc     180

aacgagctga gcgacttcca gaccaacgtg gaccccgtgg gcgagagcgt gagctacagc     240

atccacagca ccgccaaggt ggtgctgacc agggaggacg tgcacagcca ggtgatctgc     300

gaggtggccc acgtgaccct gcagggcgac cccctgaggg gcaccgccaa cctgagcgag     360

accatcaggg aatccaaata cggaccacca tgcccaccat gcccaggagg tggcggaagt     420

gtgcccccca ccctggaggt gacccagcag cccgtgaggg ccgagaacca ggtgaacgtg     480

acctgccagg tgaggaagtt ctacccccag aggctgcagc tgacctggct ggagaacggc     540

aacgtgagca ggaccgagac cgccagcacc gtgaccgaga acaaggacgg cacctacaac     600

tggatgagct ggctgctggt gaacgtgagc gcccacaggg acgacgtgaa gctgacctgc     660

caggtggagc acgacggcca gcccgccgtg agcaagagcc acgacctgaa ggtgagcgaa     720

tccaaatacg gaccaccatg cccaccatgc ccaggcggtg gcggcagc                  768


<210> 72
<211> 399
<212> DNA
<213> Artificial Sequence


<220> 
<223> CAR spacer 2S5

<400> 72
gagagcaagt acggcccccc ctgccccccc tgccccggtg gcggtggaag tgtgcccccc      60

accctggagg tgacccagca gcccgtgagg gccgagaacc aggtgaacgt gacctgccag     120

gtgaggaagt tctaccccca gaggctgcag ctgacctggc tggagaacgg caacgtgagc     180

aggaccgaga ccgccagcac cgtgaccgag aacaaggacg gcacctacaa ctggatgagc     240

tggctgctgg tgaacgtgag cgcccacagg gacgacgtga agctgacctg ccaggtggag     300

cacgacggcc agcccgccgt gagcaagagc cacgacctga aggtgagcga atccaaatac     360

ggaccaccat gcccaccatg cccaggcggt ggcggcagc                            399


<210> 73
<211> 645
<212> DNA
<213> Artificial Sequence


<220> 
<223> CAR spacer M6

<400> 73
ggtggcggtg gaagtgccaa gcccagcgcc cccgtggtga gcggccccgc cgccagggcc      60

accccccagc acaccgtgag cttcacctgc gagagccacg gcttcagccc cagggacatc     120

accctgaagt ggttcaagaa cggcaacgag ctgagcgact tccagaccaa cgtggacccc     180

gtgggcgaga gcgtgagcta cagcatccac agcaccgcca aggtggtgct gaccagggag     240

gacgtgcaca gccaggtgat ctgcgaggtg gcccacgtga ccctgcaggg cgaccccctg     300

aggggcaccg ccaacctgag cgagaccatc agggtgcccc ccaccctgga ggtgacccag     360

cagcccgtga gggccgagaa ccaggtgaac gtgacctgcc aggtgaggaa gttctacccc     420

cagaggctgc agctgacctg gctggagaac ggcaacgtga gcaggaccga gaccgccagc     480

accgtgaccg agaacaagga cggcacctac aactggatga gctggctgct ggtgaacgtg     540

agcgcccaca gggacgacgt gaagctgacc tgccaggtgg agcacgacgg ccagcccgcc     600

gtgagcaaga gccacgacct gaaggtgagc ggcggtggcg gcagc                     645


<210> 74
<211> 2037
<212> DNA
<213> Artificial Sequence


<220> 
<223> CAR M1

<400> 74
gccaccatgg agttcggcct gagctggctg ttcctggtgg ccatcctgaa gggcgtgcag      60

tgcagcaggg acatccagat gacccagacc accagcagcc tgagcgccag cctgggcgac     120

agggtgacca tcagctgcag ggccagccag gacatcagca agtacctgaa ctggtaccag     180

cagaagcccg acggcaccgt gaagctgctg atctaccaca ccagcaggct gcacagcggc     240

gtgcccagca ggttcagcgg cagcggcagc ggcaccgact acagcctgac catcagcaac     300

ctggagcagg aggacatcgc cacctacttc tgccagcagg gcaacaccct gccctacacc     360

ttcggcggcg gcaccaagct ggagctgaag aggggcggtg gaggttccgg cggtggcggt     420

tccggaggcg gtgggtcagg aggtggaggc tccgaggtgc agctgcagca gagcggcccc     480

ggcctggtgg cccccagcca gagcctgagc gtgacctgca ccgtgagcgg cgtgagcctg     540

cccgactacg gcgtgagctg gatcaggcag ccccccagga agggcctgga gtggctgggc     600

gtgatctggg gcagcgagac cacctactac aacagcgccc tgaagagcag gctgaccatc     660

atcaaggaca acagcaagag ccaggtgttc ctgaagatga acagcctgca gaccgacgac     720

accgccatct actactgcgc caagcactac tactacggcg gcagctacgc catggactac     780

tggggccagg gcaccaccgt gaccgtgagc agcgagagca agtacggccc cccctgcccc     840

ccctgccccg gtggcggtgg aagtgccaag cccagcgccc ccgtggtgag cggccccgcc     900

gccagggcca ccccccagca caccgtgagc ttcacctgcg agagccacgg cttcagcccc     960

agggacatca ccctgaagtg gttcaagaac ggcaacgagc tgagcgactt ccagaccaac    1020

gtggaccccg tgggcgagag cgtgagctac agcatccaca gcaccgccaa ggtggtgctg    1080

accagggagg acgtgcacag ccaggtgatc tgcgaggtgg cccacgtgac cctgcagggc    1140

gaccccctga ggggcaccgc caacctgagc gagaccatca gggtgccccc caccctggag    1200

gtgacccagc agcccgtgag ggccgagaac caggtgaacg tgacctgcca ggtgaggaag    1260

ttctaccccc agaggctgca gctgacctgg ctggagaacg gcaacgtgag caggaccgag    1320

accgccagca ccgtgaccga gaacaaggac ggcacctaca actggatgag ctggctgctg    1380

gtgaacgtga gcgcccacag ggacgacgtg aagctgacct gccaggtgga gcacgacggc    1440

cagcccgccg tgagcaagag ccacgacctg aaggtgagcg gcggtggcgg cagcttctgg    1500

gtgctggtgg tggtgggcgg cgtgctggcc tgctacagcc tgctggtgac cgtggccttc    1560

atcatcttct gggtgaggag caagaggagc aggctgctgc acagcgacta catgaacatg    1620

acccccagga ggcccggccc caccaggaag cactaccagc cctacgcccc ccccagggac    1680

ttcgccgcct acaggagcag ggtgaagttc agcaggagcg ccgacgcccc cgcctaccag    1740

cagggccaga accagctgta caacgagctg aacctgggca ggagggagga gtacgacgtg    1800

ctggacaaga ggaggggcag ggaccccgag atgggcggca agcccaggag gaagaacccc    1860

caggagggcc tgtacaacga gctgcagaag gacaagatgg ccgaggccta cagcgagatc    1920

ggcatgaagg gcgagaggag gaggggcaag ggccacgacg gcctgtacca gggcctgagc    1980

accgccacca aggacaccta cgacgccctg cacatgcagg ccctgccccc caggtaa       2037


<210> 75
<211> 2073
<212> DNA
<213> Artificial Sequence


<220> 
<223> CAR XM2

<400> 75
gccaccatgg agttcggcct gagctggctg ttcctggtgg ccatcctgaa gggcgtgcag      60

tgcagcaggg acatccagat gacccagacc accagcagcc tgagcgccag cctgggcgac     120

agggtgacca tcagctgcag ggccagccag gacatcagca agtacctgaa ctggtaccag     180

cagaagcccg acggcaccgt gaagctgctg atctaccaca ccagcaggct gcacagcggc     240

gtgcccagca ggttcagcgg cagcggcagc ggcaccgact acagcctgac catcagcaac     300

ctggagcagg aggacatcgc cacctacttc tgccagcagg gcaacaccct gccctacacc     360

ttcggcggcg gcaccaagct ggagctgaag aggggcggtg gaggttccgg cggtggcggt     420

tccggaggcg gtgggtcagg aggtggaggc tccgaggtgc agctgcagca gagcggcccc     480

ggcctggtgg cccccagcca gagcctgagc gtgacctgca ccgtgagcgg cgtgagcctg     540

cccgactacg gcgtgagctg gatcaggcag ccccccagga agggcctgga gtggctgggc     600

gtgatctggg gcagcgagac cacctactac aacagcgccc tgaagagcag gctgaccatc     660

atcaaggaca acagcaagag ccaggtgttc ctgaagatga acagcctgca gaccgacgac     720

accgccatct actactgcgc caagcactac tactacggcg gcagctacgc catggactac     780

tggggccagg gcaccaccgt gaccgtgagc agcgagagca agtacggccc cccctgcccc     840

ccctgccccg gtggcggtgg aagtgccaag cccagcgccc ccgtggtgag cggccccgcc     900

gccagggcca ccccccagca caccgtgagc ttcacctgcg agagccacgg cttcagcccc     960

agggacatca ccctgaagtg gttcaagaac ggcaacgagc tgagcgactt ccagaccaac    1020

gtggaccccg tgggcgagag cgtgagctac agcatccaca gcaccgccaa ggtggtgctg    1080

accagggagg acgtgcacag ccaggtgatc tgcgaggtgg cccacgtgac cctgcagggc    1140

gaccccctga ggggcaccgc caacctgagc gagaccatca gggtgccccc caccctggag    1200

gtgacccagc agcccgtgag ggccgagaac caggtgaacg tgacctgcca ggtgaggaag    1260

ttctaccccc agaggctgca gctgacctgg ctggagaacg gcaacgtgag caggaccgag    1320

accgccagca ccgtgaccga gaacaaggac ggcacctaca actggatgag ctggctgctg    1380

gtgaacgtga gcgcccacag ggacgacgtg aagctgacct gccaggtgga gcacgacggc    1440

cagcccgccg tgagcaagag ccacgacctg aaggtgagca agggcaagca cctgtgcccc    1500

agccccctgt tccccggccc cagcaagccc ttctgggtgc tggtggtggt gggcggcgtg    1560

ctggcctgct acagcctgct ggtgaccgtg gccttcatca tcttctgggt gaggagcaag    1620

aggagcaggc tgctgcacag cgactacatg aacatgaccc ccaggaggcc cggccccacc    1680

aggaagcact accagcccta cgcccccccc agggacttcg ccgcctacag gagcagggtg    1740

aagttcagca ggagcgccga cgcccccgcc taccagcagg gccagaacca gctgtacaac    1800

gagctgaacc tgggcaggag ggaggagtac gacgtgctgg acaagaggag gggcagggac    1860

cccgagatgg gcggcaagcc caggaggaag aacccccagg agggcctgta caacgagctg    1920

cagaaggaca agatggccga ggcctacagc gagatcggca tgaagggcga gaggaggagg    1980

ggcaagggcc acgacggcct gtaccagggc ctgagcaccg ccaccaagga cacctacgac    2040

gccctgcaca tgcaggccct gccccccagg taa                                 2073


<210> 76
<211> 2124
<212> DNA
<213> Artificial Sequence


<220> 
<223> CAR XM3

<400> 76
gccaccatgg agttcggcct gagctggctg ttcctggtgg ccatcctgaa gggcgtgcag      60

tgcagcaggg acatccagat gacccagacc accagcagcc tgagcgccag cctgggcgac     120

agggtgacca tcagctgcag ggccagccag gacatcagca agtacctgaa ctggtaccag     180

cagaagcccg acggcaccgt gaagctgctg atctaccaca ccagcaggct gcacagcggc     240

gtgcccagca ggttcagcgg cagcggcagc ggcaccgact acagcctgac catcagcaac     300

ctggagcagg aggacatcgc cacctacttc tgccagcagg gcaacaccct gccctacacc     360

ttcggcggcg gcaccaagct ggagctgaag aggggcggtg gaggttccgg cggtggcggt     420

tccggaggcg gtgggtcagg aggtggaggc tccgaggtgc agctgcagca gagcggcccc     480

ggcctggtgg cccccagcca gagcctgagc gtgacctgca ccgtgagcgg cgtgagcctg     540

cccgactacg gcgtgagctg gatcaggcag ccccccagga agggcctgga gtggctgggc     600

gtgatctggg gcagcgagac cacctactac aacagcgccc tgaagagcag gctgaccatc     660

atcaaggaca acagcaagag ccaggtgttc ctgaagatga acagcctgca gaccgacgac     720

accgccatct actactgcgc caagcactac tactacggcg gcagctacgc catggactac     780

tggggccagg gcaccaccgt gaccgtgagc agcgagagca agtacggccc cccctgcccc     840

ccctgccccg gtggcggtgg aagtgccaag cccagcgccc ccgtggtgag cggccccgcc     900

gccagggcca ccccccagca caccgtgagc ttcacctgcg agagccacgg cttcagcccc     960

agggacatca ccctgaagtg gttcaagaac ggcaacgagc tgagcgactt ccagaccaac    1020

gtggaccccg tgggcgagag cgtgagctac agcatccaca gcaccgccaa ggtggtgctg    1080

accagggagg acgtgcacag ccaggtgatc tgcgaggtgg cccacgtgac cctgcagggc    1140

gaccccctga ggggcaccgc caacctgagc gagaccatca gggaatccaa atacggacca    1200

ccatgcccac catgcccagg cggaggcggt agtgtgcccc ccaccctgga ggtgacccag    1260

cagcccgtga gggccgagaa ccaggtgaac gtgacctgcc aggtgaggaa gttctacccc    1320

cagaggctgc agctgacctg gctggagaac ggcaacgtga gcaggaccga gaccgccagc    1380

accgtgaccg agaacaagga cggcacctac aactggatga gctggctgct ggtgaacgtg    1440

agcgcccaca gggacgacgt gaagctgacc tgccaggtgg agcacgacgg ccagcccgcc    1500

gtgagcaaga gccacgacct gaaggtgagc aagggcaagc acctgtgccc cagccccctg    1560

ttccccggcc ccagcaagcc cttctgggtg ctggtggtgg tgggcggcgt gctggcctgc    1620

tacagcctgc tggtgaccgt ggccttcatc atcttctggg tgaggagcaa gaggagcagg    1680

ctgctgcaca gcgactacat gaacatgacc cccaggaggc ccggccccac caggaagcac    1740

taccagccct acgccccccc cagggacttc gccgcctaca ggagcagggt gaagttcagc    1800

aggagcgccg acgcccccgc ctaccagcag ggccagaacc agctgtacaa cgagctgaac    1860

ctgggcagga gggaggagta cgacgtgctg gacaagagga ggggcaggga ccccgagatg    1920

ggcggcaagc ccaggaggaa gaacccccag gagggcctgt acaacgagct gcagaaggac    1980

aagatggccg aggcctacag cgagatcggc atgaagggcg agaggaggag gggcaagggc    2040

cacgacggcc tgtaccaggg cctgagcacc gccaccaagg acacctacga cgccctgcac    2100

atgcaggccc tgccccccag gtaa                                           2124


<210> 77
<211> 2124
<212> DNA
<213> Artificial Sequence


<220> 
<223> CAR M4

<400> 77
gccaccatgg agttcggcct gagctggctg ttcctggtgg ccatcctgaa gggcgtgcag      60

tgcagcaggg acatccagat gacccagacc accagcagcc tgagcgccag cctgggcgac     120

agggtgacca tcagctgcag ggccagccag gacatcagca agtacctgaa ctggtaccag     180

cagaagcccg acggcaccgt gaagctgctg atctaccaca ccagcaggct gcacagcggc     240

gtgcccagca ggttcagcgg cagcggcagc ggcaccgact acagcctgac catcagcaac     300

ctggagcagg aggacatcgc cacctacttc tgccagcagg gcaacaccct gccctacacc     360

ttcggcggcg gcaccaagct ggagctgaag aggggcggtg gaggttccgg cggtggcggt     420

tccggaggcg gtgggtcagg aggtggaggc tccgaggtgc agctgcagca gagcggcccc     480

ggcctggtgg cccccagcca gagcctgagc gtgacctgca ccgtgagcgg cgtgagcctg     540

cccgactacg gcgtgagctg gatcaggcag ccccccagga agggcctgga gtggctgggc     600

gtgatctggg gcagcgagac cacctactac aacagcgccc tgaagagcag gctgaccatc     660

atcaaggaca acagcaagag ccaggtgttc ctgaagatga acagcctgca gaccgacgac     720

accgccatct actactgcgc caagcactac tactacggcg gcagctacgc catggactac     780

tggggccagg gcaccaccgt gaccgtgagc agcgagagca agtacggccc cccctgcccc     840

ccctgccccg gtggcggtgg aagtgccaag cccagcgccc ccgtggtgag cggccccgcc     900

gccagggcca ccccccagca caccgtgagc ttcacctgcg agagccacgg cttcagcccc     960

agggacatca ccctgaagtg gttcaagaac ggcaacgagc tgagcgactt ccagaccaac    1020

gtggaccccg tgggcgagag cgtgagctac agcatccaca gcaccgccaa ggtggtgctg    1080

accagggagg acgtgcacag ccaggtgatc tgcgaggtgg cccacgtgac cctgcagggc    1140

gaccccctga ggggcaccgc caacctgagc gagaccatca gggaatccaa atacggacca    1200

ccatgcccac catgcccagg aggtggcgga agtgtgcccc ccaccctgga ggtgacccag    1260

cagcccgtga gggccgagaa ccaggtgaac gtgacctgcc aggtgaggaa gttctacccc    1320

cagaggctgc agctgacctg gctggagaac ggcaacgtga gcaggaccga gaccgccagc    1380

accgtgaccg agaacaagga cggcacctac aactggatga gctggctgct ggtgaacgtg    1440

agcgcccaca gggacgacgt gaagctgacc tgccaggtgg agcacgacgg ccagcccgcc    1500

gtgagcaaga gccacgacct gaaggtgagc gaatccaaat acggaccacc atgcccacca    1560

tgcccaggcg gtggcggcag cttctgggtg ctggtggtgg tgggcggcgt gctggcctgc    1620

tacagcctgc tggtgaccgt ggccttcatc atcttctggg tgaggagcaa gaggagcagg    1680

ctgctgcaca gcgactacat gaacatgacc cccaggaggc ccggccccac caggaagcac    1740

taccagccct acgccccccc cagggacttc gccgcctaca ggagcagggt gaagttcagc    1800

aggagcgccg acgcccccgc ctaccagcag ggccagaacc agctgtacaa cgagctgaac    1860

ctgggcagga gggaggagta cgacgtgctg gacaagagga ggggcaggga ccccgagatg    1920

ggcggcaagc ccaggaggaa gaacccccag gagggcctgt acaacgagct gcagaaggac    1980

aagatggccg aggcctacag cgagatcggc atgaagggcg agaggaggag gggcaagggc    2040

cacgacggcc tgtaccaggg cctgagcacc gccaccaagg acacctacga cgccctgcac    2100

atgcaggccc tgccccccag gtaa                                           2124


<210> 78
<211> 1755
<212> DNA
<213> Artificial Sequence


<220> 
<223> CAR 2S5

<400> 78
gccaccatgg agttcggcct gagctggctg ttcctggtgg ccatcctgaa gggcgtgcag      60

tgcagcaggg acatccagat gacccagacc accagcagcc tgagcgccag cctgggcgac     120

agggtgacca tcagctgcag ggccagccag gacatcagca agtacctgaa ctggtaccag     180

cagaagcccg acggcaccgt gaagctgctg atctaccaca ccagcaggct gcacagcggc     240

gtgcccagca ggttcagcgg cagcggcagc ggcaccgact acagcctgac catcagcaac     300

ctggagcagg aggacatcgc cacctacttc tgccagcagg gcaacaccct gccctacacc     360

ttcggcggcg gcaccaagct ggagctgaag aggggcggtg gaggttccgg cggtggcggt     420

tccggaggcg gtgggtcagg aggtggaggc tccgaggtgc agctgcagca gagcggcccc     480

ggcctggtgg cccccagcca gagcctgagc gtgacctgca ccgtgagcgg cgtgagcctg     540

cccgactacg gcgtgagctg gatcaggcag ccccccagga agggcctgga gtggctgggc     600

gtgatctggg gcagcgagac cacctactac aacagcgccc tgaagagcag gctgaccatc     660

atcaaggaca acagcaagag ccaggtgttc ctgaagatga acagcctgca gaccgacgac     720

accgccatct actactgcgc caagcactac tactacggcg gcagctacgc catggactac     780

tggggccagg gcaccaccgt gaccgtgagc agcgagagca agtacggccc cccctgcccc     840

ccctgccccg gtggcggtgg aagtgtgccc cccaccctgg aggtgaccca gcagcccgtg     900

agggccgaga accaggtgaa cgtgacctgc caggtgagga agttctaccc ccagaggctg     960

cagctgacct ggctggagaa cggcaacgtg agcaggaccg agaccgccag caccgtgacc    1020

gagaacaagg acggcaccta caactggatg agctggctgc tggtgaacgt gagcgcccac    1080

agggacgacg tgaagctgac ctgccaggtg gagcacgacg gccagcccgc cgtgagcaag    1140

agccacgacc tgaaggtgag cgaatccaaa tacggaccac catgcccacc atgcccaggc    1200

ggtggcggca gcttctgggt gctggtggtg gtgggcggcg tgctggcctg ctacagcctg    1260

ctggtgaccg tggccttcat catcttctgg gtgaggagca agaggagcag gctgctgcac    1320

agcgactaca tgaacatgac ccccaggagg cccggcccca ccaggaagca ctaccagccc    1380

tacgcccccc ccagggactt cgccgcctac aggagcaggg tgaagttcag caggagcgcc    1440

gacgcccccg cctaccagca gggccagaac cagctgtaca acgagctgaa cctgggcagg    1500

agggaggagt acgacgtgct ggacaagagg aggggcaggg accccgagat gggcggcaag    1560

cccaggagga agaaccccca ggagggcctg tacaacgagc tgcagaagga caagatggcc    1620

gaggcctaca gcgagatcgg catgaagggc gagaggagga ggggcaaggg ccacgacggc    1680

ctgtaccagg gcctgagcac cgccaccaag gacacctacg acgccctgca catgcaggcc    1740

ctgcccccca ggtaa                                                     1755


<210> 79
<211> 2001
<212> DNA
<213> Artificial Sequence


<220> 
<223> CAR M6

<400> 79
gccaccatgg agttcggcct gagctggctg ttcctggtgg ccatcctgaa gggcgtgcag      60

tgcagcaggg acatccagat gacccagacc accagcagcc tgagcgccag cctgggcgac     120

agggtgacca tcagctgcag ggccagccag gacatcagca agtacctgaa ctggtaccag     180

cagaagcccg acggcaccgt gaagctgctg atctaccaca ccagcaggct gcacagcggc     240

gtgcccagca ggttcagcgg cagcggcagc ggcaccgact acagcctgac catcagcaac     300

ctggagcagg aggacatcgc cacctacttc tgccagcagg gcaacaccct gccctacacc     360

ttcggcggcg gcaccaagct ggagctgaag aggggcggtg gaggttccgg cggtggcggt     420

tccggaggcg gtgggtcagg aggtggaggc tccgaggtgc agctgcagca gagcggcccc     480

ggcctggtgg cccccagcca gagcctgagc gtgacctgca ccgtgagcgg cgtgagcctg     540

cccgactacg gcgtgagctg gatcaggcag ccccccagga agggcctgga gtggctgggc     600

gtgatctggg gcagcgagac cacctactac aacagcgccc tgaagagcag gctgaccatc     660

atcaaggaca acagcaagag ccaggtgttc ctgaagatga acagcctgca gaccgacgac     720

accgccatct actactgcgc caagcactac tactacggcg gcagctacgc catggactac     780

tggggccagg gcaccaccgt gaccgtgagc agcggtggcg gtggaagtgc caagcccagc     840

gcccccgtgg tgagcggccc cgccgccagg gccacccccc agcacaccgt gagcttcacc     900

tgcgagagcc acggcttcag ccccagggac atcaccctga agtggttcaa gaacggcaac     960

gagctgagcg acttccagac caacgtggac cccgtgggcg agagcgtgag ctacagcatc    1020

cacagcaccg ccaaggtggt gctgaccagg gaggacgtgc acagccaggt gatctgcgag    1080

gtggcccacg tgaccctgca gggcgacccc ctgaggggca ccgccaacct gagcgagacc    1140

atcagggtgc cccccaccct ggaggtgacc cagcagcccg tgagggccga gaaccaggtg    1200

aacgtgacct gccaggtgag gaagttctac ccccagaggc tgcagctgac ctggctggag    1260

aacggcaacg tgagcaggac cgagaccgcc agcaccgtga ccgagaacaa ggacggcacc    1320

tacaactgga tgagctggct gctggtgaac gtgagcgccc acagggacga cgtgaagctg    1380

acctgccagg tggagcacga cggccagccc gccgtgagca agagccacga cctgaaggtg    1440

agcggcggtg gcggcagctt ctgggtgctg gtggtggtgg gcggcgtgct ggcctgctac    1500

agcctgctgg tgaccgtggc cttcatcatc ttctgggtga ggagcaagag gagcaggctg    1560

ctgcacagcg actacatgaa catgaccccc aggaggcccg gccccaccag gaagcactac    1620

cagccctacg ccccccccag ggacttcgcc gcctacagga gcagggtgaa gttcagcagg    1680

agcgccgacg cccccgccta ccagcagggc cagaaccagc tgtacaacga gctgaacctg    1740

ggcaggaggg aggagtacga cgtgctggac aagaggaggg gcagggaccc cgagatgggc    1800

ggcaagccca ggaggaagaa cccccaggag ggcctgtaca acgagctgca gaaggacaag    1860

atggccgagg cctacagcga gatcggcatg aagggcgaga ggaggagggg caagggccac    1920

gacggcctgt accagggcct gagcaccgcc accaaggaca cctacgacgc cctgcacatg    1980

caggccctgc cccccaggta a                                              2001


<210> 80
<211> 15
<212> PRT
<213> Homo sapiens


<400> 80
Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  

<210> 81
<211> 12
<212> PRT
<213> Homo sapiens


<400> 81
Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          

<210> 82
<211> 16
<212> PRT
<213> Homo sapiens


<400> 82
Glu Leu Lys Thr Pro Leu Gly Asp Thr His Thr Cys Pro Arg Cys Pro 
1               5                   10                  15      



<210> 83
<211> 12
<212> PRT
<213> Homo sapiens


<400> 83
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10          

<210> 84
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker C2

<400> 84
Glu Thr Ile Arg Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10                  15      
Gly Gly Gly Gly Ser Val Pro 
            20              

