﻿               SEQUENCE LISTING

<110> Phi Pharma

<120> Oligomeric compounds binding specifically to proteoglycans

<130> AD2400 PCT BS

<150> EP20 215 263.3
<151> 2020-12-18

<160> 91

<170> BiSSAP 1.3.6

<210> 1
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker1

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-His

<400> 1
Xaa Ser Lys Cys 
1               

<210> 2
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker2

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-His

<400> 2
Xaa Ser Lys Ser Lys Cys 
1               5       

<210> 3
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker3

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-His

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is beta-alanine

<400> 3
Xaa Ser Lys Xaa Ser Lys Cys 
1               5           

<210> 4
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker4

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-His

<220> 
<221> VARIANT
<222> 5
<223> Xaa at position 5 is beta-alanine

<400> 4
Xaa Ser Lys Ser Xaa Lys Cys 
1               5           

<210> 5
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker5

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-His

<220> 
<221> VARIANT
<222> 5
<223> Lys at position 5 is connected to Cys at position 6 via a PEG1,
      PEG5, PEG16 or PEG36 linker

<400> 5
Xaa Ser Lys Ser Lys Cys 
1               5       

<210> 6
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker6

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-His

<220> 
<221> VARIANT
<222> 3
<223> Lys at position 3 is connected to Cys at position 4 via a PEG1,
      PEG5, PEG16 or PEG36 linker

<400> 6
Xaa Ser Lys Cys 
1               

<210> 7
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker7

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-His

<220> 
<221> VARIANT
<222> 3
<223> Lys at position 3 is connected to Lys at position 4 via a PEG1,
      PEG3 or PEG5 linker

<400> 7
Xaa Ser Lys Lys Cys 
1               5   

<210> 8
<211> 3
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker8

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-His, wherein D-His is connected to L-Lys
      at position 2 via a PEG2 or PEG5 linker

<400> 8
Xaa Lys Cys 
1           

<210> 9
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker9

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-His

<220> 
<221> VARIANT
<222> 3
<223> Xaa at position 3 is an amino acid comprising two primary amine
      groups

<220> 
<221> VARIANT
<222> 5
<223> Xaa at position 5 is an amino acid comprising two primary amine
      groups

<400> 9
Xaa Ser Xaa Ser Xaa Cys 
1               5       

<210> 10
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker10

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-His

<220> 
<221> VARIANT
<222> 3
<223> Xaa at position 3 is an amino acid comprising two primary amine
      groups

<400> 10
Xaa Ser Xaa Cys 
1               

<210> 11
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker11

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-His

<400> 11
Xaa Ser Lys Gly Lys Cys 
1               5       

<210> 12
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker12

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-His

<400> 12
Xaa Gly Lys Ser Lys Cys 
1               5       

<210> 13
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker13

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-His

<400> 13
Xaa Gly Lys Gly Lys Cys 
1               5       

<210> 14
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker14

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-His

<400> 14
Xaa Gly Lys Cys 
1               

<210> 15
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker15

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-His

<220> 
<221> VARIANT
<222> 3
<223> Xaa at position 3 is an amino acid comprising two primary amine
      groups

<220> 
<221> VARIANT
<222> 5
<223> Xaa at position 5 is an amino acid comprising two primary amine
      groups

<400> 15
Xaa Ser Xaa Gly Xaa Cys 
1               5       

<210> 16
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker16

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-His

<220> 
<221> VARIANT
<222> 3
<223> Xaa at position 3 is an amino acid comprising two primary amine
      groups

<220> 
<221> VARIANT
<222> 5
<223> Xaa at position 5 is an amino acid comprising two primary amine
      groups

<400> 16
Xaa Gly Xaa Ser Xaa Cys 
1               5       

<210> 17
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker17

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-His

<220> 
<221> VARIANT
<222> 3
<223> Xaa at position 3 is an amino acid comprising two primary amine
      groups

<220> 
<221> VARIANT
<222> 5
<223> Xaa at position 5 is an amino acid comprising two primary amine
      groups

<400> 17
Xaa Gly Xaa Gly Xaa Cys 
1               5       

<210> 18
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker18

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-His

<220> 
<221> VARIANT
<222> 3
<223> Xaa at position 3 is an amino acid comprising two primary amine
      groups

<400> 18
Xaa Gly Xaa Cys 
1               

<210> 19
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker19

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-His

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is L-propargylglycine

<400> 19
Xaa Ser Lys Xaa 
1               

<210> 20
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker20

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-His

<220> 
<221> VARIANT
<222> 6
<223> Xaa at position 6 is L-propargylglycine

<400> 20
Xaa Ser Lys Ser Lys Xaa 
1               5       

<210> 21
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker21

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-His

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is L-biocytin

<400> 21
Xaa Ser Lys Xaa 
1               

<210> 22
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker22

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-His

<220> 
<221> VARIANT
<222> 6
<223> Xaa at position 6 is L-biocytin

<400> 22
Xaa Ser Lys Ser Lys Xaa 
1               5       

<210> 23
<211> 3
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker23

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-His

<400> 23
Xaa Lys Cys 
1           

<210> 24
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker24

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-His

<400> 24
Xaa Lys Ser Lys Cys 
1               5   

<210> 25
<211> 3
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker25

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-His

<220> 
<221> VARIANT
<222> 2
<223> Lys at position 2 is connected to Cys at position 3 via a PEG1
      linker

<400> 25
Xaa Lys Cys 
1           

<210> 26
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker26

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-His

<220> 
<221> VARIANT
<222> 4
<223> Lys at position 4 is connected to Cys at position 5 via a PEG1
      linker

<400> 26
Xaa Lys Ser Lys Cys 
1               5   

<210> 27
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker27

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-His

<400> 27
Xaa Ser Ser Lys Cys 
1               5   

<210> 28
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker28

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-His

<400> 28
Xaa Ser Ser Lys Ser Lys Cys 
1               5           

<210> 29
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker29

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-His

<400> 29
Xaa Ser Lys Ser Ser Cys 
1               5       

<210> 30
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker 30

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-His

<400> 30
Xaa Ser Lys Ser Lys Ser Ser Cys 
1               5               

<210> 31
<211> 3
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker31

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-His

<220> 
<221> VARIANT
<222> 3
<223> L-Lys at position 3 is connected to L-Ser-D-His via the primary
      amine group in the L-Lys side chain

<400> 31
Xaa Ser Lys 
1           

<210> 32
<211> 3
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker32

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-His

<220> 
<221> VARIANT
<222> 3
<223> L-Lys at position 3 is connected to
      L-Ser-L-Lys[ε-N-L-Ser-D-His]-L-Ser-D-His via the primary amine
      group in the L-Lys side chain

<400> 32
Xaa Ser Lys 
1           

<210> 33
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker33

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-His

<220> 
<221> VARIANT
<222> 3
<223> L-Lys at position 3 is connected to L-Ser-D-His via the primary
      amine group in the L-Lys side chain

<220> 
<221> VARIANT
<222> 5
<223> L-Lys at position 5 is connected to L-Ser-D-His via the primary
      amine group in the L-Lys side chain

<400> 33
Xaa Ser Lys Ser Lys 
1               5   

<210> 34
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker34

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-His

<220> 
<221> VARIANT
<222> 3
<223> L-Lys at position 3 is connected to
      L-Ser-L-Lys[ε-N-L-Ser-D-His]-L-Ser-D-His via the primary amine
      group in the L-Lys side chain

<220> 
<221> VARIANT
<222> 5
<223> L-Lys at position 5 is connected to L-Ser-D-His via the primary
      amine group in the L-Lys side chain

<400> 34
Xaa Ser Lys Ser Lys 
1               5   

<210> 35
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker35

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-His

<220> 
<221> VARIANT
<222> 3
<223> L-Lys at position 3 is connected to L-Ser-D-His via the primary
      amine group in the L-Lys side chain

<220> 
<221> VARIANT
<222> 5
<223> L-Lys at position 5 is connected to
      L-Ser-L-Lys[ε-N-L-Ser-D-His]-L-Ser-D-His via the primary amine
      group in the L-Lys side chain

<400> 35
Xaa Ser Lys Ser Lys 
1               5   

<210> 36
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker36

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-His

<220> 
<221> VARIANT
<222> 3
<223> L-Lys at position 3 is connected to
      L-Ser-L-Lys[ε-N-L-Ser-D-His]-L-Ser-D-His via the primary amine
      group in the L-Lys side chain

<220> 
<221> VARIANT
<222> 5
<223> L-Lys at position 5 is connected to
      L-Ser-L-Lys[ε-N-L-Ser-D-His]-L-Ser-D-His via the primary amine
      group in the L-Lys side chain

<400> 36
Xaa Ser Lys Ser Lys 
1               5   

<210> 37
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 1

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Val

<220> 
<221> VARIANT
<222> 7
<223> Xaa at position 7 is L-Ornithine

<400> 37
Arg Tyr Phe Xaa Arg Ile Xaa Tyr Arg 
1               5                   

<210> 38
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 2

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Val

<400> 38
Arg Arg Phe Xaa Tyr Ile Tyr Arg Arg 
1               5                   

<210> 39
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 3

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Val

<400> 39
Arg Tyr Phe Xaa Arg Ile Tyr Arg Arg 
1               5                   

<210> 40
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 4

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Val

<220> 
<221> VARIANT
<222> 5
<223> Xaa at position 5 is D-Arg

<220> 
<221> VARIANT
<222> 7
<223> Xaa at position 7 is L-Ornithine

<400> 40
Arg Tyr Phe Xaa Xaa Ile Xaa Tyr Arg 
1               5                   

<210> 41
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 5

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Val

<220> 
<221> VARIANT
<222> 6
<223> Xaa at position 6 is D-Ile

<220> 
<221> VARIANT
<222> 7
<223> Xaa at position 7 is L-Ornithine

<400> 41
Arg Tyr Phe Xaa Arg Xaa Xaa Tyr Arg 
1               5                   

<210> 42
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 6

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Val

<220> 
<221> VARIANT
<222> 5
<223> Xaa at position 5 is D-Arg

<220> 
<221> VARIANT
<222> 6
<223> Xaa at position 6 is D-Ile

<220> 
<221> VARIANT
<222> 7
<223> Xaa at position 7 is L-Ornithine

<400> 42
Arg Tyr Phe Xaa Xaa Xaa Xaa Tyr Arg 
1               5                   

<210> 43
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 7

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Val

<400> 43
Arg Arg Phe Xaa Tyr Ile Tyr Lys Arg 
1               5                   

<210> 44
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 8

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Gln

<400> 44
Arg Arg Phe Xaa Tyr Ile Tyr Lys Arg 
1               5                   

<210> 45
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 9

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Val

<400> 45
Arg Tyr Phe Xaa Arg Ile Tyr Lys Arg 
1               5                   

<210> 46
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 10

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Val

<400> 46
Arg Tyr Phe Xaa Arg Ile Tyr Arg Lys 
1               5                   

<210> 47
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 11

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Ala

<400> 47
Arg Arg Phe Xaa Tyr Ile Tyr Lys Arg 
1               5                   

<210> 48
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 12

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Pro

<400> 48
Arg Arg Phe Xaa Tyr Ile Tyr Lys Arg 
1               5                   

<210> 49
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 13

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Val

<400> 49
Arg Tyr Phe Xaa Arg Ile Lys Tyr Arg 
1               5                   

<210> 50
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 14

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Gln

<400> 50
Arg Tyr Phe Xaa Arg Ile Lys Tyr Arg 
1               5                   

<210> 51
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 15

<220> 
<221> VARIANT
<222> 3
<223> Xaa at position 3 is D-Val

<220> 
<221> VARIANT
<222> 6
<223> Xaa at position 6 is L-Ornithine

<400> 51
Tyr Phe Xaa Arg Ile Xaa Tyr Arg 
1               5               

<210> 52
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 16

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is L-2-amino-4-guanidinobutyric acid

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Val

<220> 
<221> VARIANT
<222> 5
<223> Xaa at position 5 is L-2-amino-4-guanidinobutyric acid

<220> 
<221> VARIANT
<222> 9
<223> Xaa at position 9 is L-2-amino-4-guanidinobutyric acid

<400> 52
Xaa Tyr Phe Xaa Xaa Ile Lys Tyr Xaa 
1               5                   

<210> 53
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 17

<220> 
<221> VARIANT
<222> 3
<223> Xaa at position 3 is D-Val

<400> 53
Tyr Phe Xaa Arg Ile Lys Tyr Arg 
1               5               

<210> 54
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 18

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-Arg

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Val

<400> 54
Xaa Tyr Phe Xaa Arg Ile Lys Tyr Arg 
1               5                   

<210> 55
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 19

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Val

<220> 
<221> VARIANT
<222> 5
<223> Xaa at position 5 is D-Arg

<400> 55
Arg Tyr Phe Xaa Xaa Ile Lys Tyr Arg 
1               5                   

<210> 56
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 20

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is D-Arg

<220> 
<221> VARIANT
<222> 2
<223> Xaa at position 2 is D-Arg

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 2 is D-Val

<400> 56
Xaa Xaa Phe Xaa Tyr Ile Tyr Arg Arg 
1               5                   

<210> 57
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 21

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Gln

<400> 57
Arg Ser Thr Xaa Arg Tyr Arg Val Arg 
1               5                   

<210> 58
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 22

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Val

<400> 58
Arg Tyr Phe Xaa Arg Ile Lys Tyr Arg 
1               5                   

<210> 59
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 23

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Val

<400> 59
Arg Tyr Phe Xaa Arg Ile Lys Ala Arg 
1               5                   

<210> 60
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 24

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Val

<400> 60
Arg Ala Ala Xaa Arg Ala Lys Tyr Arg 
1               5                   

<210> 61
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 25

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Val

<400> 61
Arg Ala Ala Xaa Arg Ile Lys Tyr Arg 
1               5                   

<210> 62
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 26

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Gln

<400> 62
Arg Ser Thr Xaa Arg Tyr Arg Val Arg 
1               5                   

<210> 63
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 27

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Gln

<400> 63
Arg Ser Thr Xaa Arg Tyr Lys Val Arg 
1               5                   

<210> 64
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 28

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Gly

<400> 64
Arg Gly Gly Xaa Arg Gly Lys Gly Arg 
1               5                   

<210> 65
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 29

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-His

<400> 65
Arg His His Xaa Arg His Lys His Arg 
1               5                   

<210> 66
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 30

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Val

<400> 66
Arg Val Val Xaa Arg Val Lys Val Arg 
1               5                   

<210> 67
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 31

<400> 67
Arg Leu Leu Ile Arg Leu Lys Leu Arg 
1               5                   

<210> 68
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 32

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Met

<400> 68
Arg Met Met Xaa Arg Met Lys Met Arg 
1               5                   

<210> 69
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 33

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Ile

<400> 69
Arg Ile Ile Xaa Arg Ile Lys Ile Arg 
1               5                   

<210> 70
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 34

<220> 
<221> VARIANT
<222> 6
<223> Xaa at position 6 is D-Ile

<400> 70
Arg Tyr Phe Val Arg Xaa Lys Tyr Arg 
1               5                   

<210> 71
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 35

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Val

<400> 71
Arg Tyr Lys Xaa Phe Ile Lys Tyr Arg 
1               5                   

<210> 72
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 36

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Val

<400> 72
Arg Tyr Lys Xaa Ala Ile Lys Tyr Arg 
1               5                   

<210> 73
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 37

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Val

<400> 73
Arg Tyr Lys Xaa Arg Ile Ala Tyr Arg 
1               5                   

<210> 74
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 38

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Val

<400> 74
Arg Tyr Lys Xaa Arg Ile Phe Tyr Arg 
1               5                   

<210> 75
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 39

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Val

<400> 75
Arg Tyr Lys Xaa Lys Phe Ile Tyr Arg 
1               5                   

<210> 76
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 40

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Val

<400> 76
Arg Tyr Lys Xaa Phe Ile Arg Tyr Arg 
1               5                   

<210> 77
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 41

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Val

<400> 77
Arg Tyr Lys Xaa Arg Phe Ile Tyr Arg 
1               5                   

<210> 78
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 42

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Ile

<400> 78
Arg Met Lys Xaa Val Met Lys Phe Arg 
1               5                   

<210> 79
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 43

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Phe

<400> 79
Arg Phe Lys Xaa Phe Phe Lys Phe Arg 
1               5                   

<210> 80
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 44

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Val

<400> 80
Arg Tyr Lys Xaa Arg Ile Lys 
1               5           

<210> 81
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 45

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Val

<400> 81
Arg Tyr Lys Xaa Arg Ile Lys Tyr Phe 
1               5                   

<210> 82
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 46

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Val

<400> 82
Arg Tyr Lys Xaa Arg Ile Lys Tyr Ala 
1               5                   

<210> 83
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 47

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Val

<400> 83
Arg Tyr Lys Xaa Arg Ile Lys His His 
1               5                   

<210> 84
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 45

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Ile

<400> 84
Arg Met Lys Xaa Arg Val Lys 
1               5           

<210> 85
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 46

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Ile

<400> 85
Arg Met Lys Xaa Arg Val Lys Phe Met 
1               5                   

<210> 86
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 47

<400> 86
Arg Leu Lys Ile Arg Leu Lys Leu Leu 
1               5                   

<210> 87
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial binding peptide 48

<220> 
<221> VARIANT
<222> 4
<223> Xaa at position 4 is D-Val

<220> 
<221> VARIANT
<222> 9
<223> Xaa at position 9 is D-Arg

<400> 87
Arg Tyr Lys Xaa Arg Ile Lys Tyr Xaa 
1               5                   

<210> 88
<211> 261
<212> PRT
<213> Homo sapiens


<220> 
<223> bcl-2-binding component 3 isoform 1

<400> 88
Met Lys Phe Gly Met Gly Ser Ala Gln Ala Cys Pro Cys Gln Val Pro 
1               5                   10                  15      
Arg Ala Ala Ser Thr Thr Trp Val Pro Cys Gln Ile Cys Gly Pro Arg 
            20                  25                  30          
Glu Arg His Gly Pro Arg Thr Pro Gly Gly Gln Leu Pro Gly Ala Arg 
        35                  40                  45              
Arg Gly Pro Gly Pro Arg Arg Pro Ala Pro Leu Pro Ala Arg Pro Pro 
    50                  55                  60                  
Gly Ala Leu Gly Ser Val Leu Arg Pro Leu Arg Ala Arg Pro Gly Cys 
65                  70                  75                  80  
Arg Pro Arg Arg Pro His Pro Ala Ala Arg Cys Leu Pro Leu Arg Pro 
                85                  90                  95      
His Arg Pro Thr Arg Arg His Arg Arg Pro Gly Gly Phe Pro Leu Ala 
            100                 105                 110         
Trp Gly Ser Pro Gln Pro Ala Pro Arg Pro Ala Pro Gly Arg Ser Ser 
        115                 120                 125             
Ala Leu Ala Leu Ala Gly Gly Ala Ala Pro Gly Val Ala Arg Ala Gln 
    130                 135                 140                 
Arg Pro Gly Gly Ser Gly Gly Arg Ser His Pro Gly Gly Pro Gly Ser 
145                 150                 155                 160 
Pro Arg Gly Gly Gly Thr Val Gly Pro Gly Asp Arg Gly Pro Ala Ala 
                165                 170                 175     
Ala Asp Gly Gly Arg Pro Gln Arg Thr Val Arg Ala Ala Glu Thr Arg 
            180                 185                 190         
Gly Ala Ala Ala Ala Pro Pro Leu Thr Leu Glu Gly Pro Val Gln Ser 
        195                 200                 205             
His His Gly Thr Pro Ala Leu Thr Gln Gly Pro Gln Ser Pro Arg Asp 
    210                 215                 220                 
Gly Ala Gln Leu Gly Ala Cys Thr Arg Pro Val Asp Val Arg Asp Ser 
225                 230                 235                 240 
Gly Gly Arg Pro Leu Pro Pro Pro Asp Thr Leu Ala Ser Ala Gly Asp 
                245                 250                 255     
Phe Leu Cys Thr Met 
            260     

<210> 89
<211> 131
<212> PRT
<213> Homo sapiens


<220> 
<223> bcl-2-binding component 3 isoform 2

<400> 89
Met Lys Phe Gly Met Gly Ser Ala Gln Ala Cys Pro Cys Gln Val Pro 
1               5                   10                  15      
Arg Ala Ala Ser Thr Thr Trp Val Pro Cys Gln Ile Cys Gly Pro Gln 
            20                  25                  30          
Pro Ser Leu Ser Leu Ala Glu Gln His Leu Glu Ser Pro Val Pro Ser 
        35                  40                  45              
Ala Pro Gly Ala Leu Ala Gly Gly Pro Thr Gln Ala Ala Pro Gly Val 
    50                  55                  60                  
Arg Gly Glu Glu Glu Gln Trp Ala Arg Glu Ile Gly Ala Gln Leu Arg 
65                  70                  75                  80  
Arg Met Ala Asp Asp Leu Asn Ala Gln Tyr Glu Arg Arg Arg Gln Glu 
                85                  90                  95      
Glu Gln Gln Arg His Arg Pro Ser Pro Trp Arg Val Leu Tyr Asn Leu 
            100                 105                 110         
Ile Met Gly Leu Leu Pro Leu Pro Arg Gly His Arg Ala Pro Glu Met 
        115                 120                 125             
Glu Pro Asn 
    130     

<210> 90
<211> 101
<212> PRT
<213> Homo sapiens


<220> 
<223> bcl-2-binding component 3 isoform 3

<400> 90
Met Lys Phe Gly Met Gly Ser Ala Gln Ala Cys Pro Cys Gln Val Pro 
1               5                   10                  15      
Arg Ala Ala Ser Thr Thr Trp Val Pro Cys Gln Ile Cys Glu Thr Arg 
            20                  25                  30          
Gly Ala Ala Ala Ala Pro Pro Leu Thr Leu Glu Gly Pro Val Gln Ser 
        35                  40                  45              
His His Gly Thr Pro Ala Leu Thr Gln Gly Pro Gln Ser Pro Arg Asp 
    50                  55                  60                  
Gly Ala Gln Leu Gly Ala Cys Thr Arg Pro Val Asp Val Arg Asp Ser 
65                  70                  75                  80  
Gly Gly Arg Pro Leu Pro Pro Pro Asp Thr Leu Ala Ser Ala Gly Asp 
                85                  90                  95      
Phe Leu Cys Thr Met 
            100     

<210> 91
<211> 193
<212> PRT
<213> Homo sapiens


<220> 
<223> bcl-2-binding component 3 isoform 4

<400> 91
Met Ala Arg Ala Arg Gln Glu Gly Ser Ser Pro Glu Pro Val Glu Gly 
1               5                   10                  15      
Leu Ala Arg Asp Gly Pro Arg Pro Phe Pro Leu Gly Arg Leu Val Pro 
            20                  25                  30          
Ser Ala Val Ser Cys Gly Leu Cys Glu Pro Gly Leu Ala Ala Ala Pro 
        35                  40                  45              
Ala Ala Pro Thr Leu Leu Pro Ala Ala Tyr Leu Cys Ala Pro Thr Ala 
    50                  55                  60                  
Pro Pro Ala Val Thr Ala Ala Leu Gly Gly Ser Arg Trp Pro Gly Gly 
65                  70                  75                  80  
Pro Arg Ser Arg Pro Arg Gly Pro Arg Pro Asp Gly Pro Gln Pro Ser 
                85                  90                  95      
Leu Ser Leu Ala Glu Gln His Leu Glu Ser Pro Val Pro Ser Ala Pro 
            100                 105                 110         
Gly Ala Leu Ala Gly Gly Pro Thr Gln Ala Ala Pro Gly Val Arg Gly 
        115                 120                 125             
Glu Glu Glu Gln Trp Ala Arg Glu Ile Gly Ala Gln Leu Arg Arg Met 
    130                 135                 140                 
Ala Asp Asp Leu Asn Ala Gln Tyr Glu Arg Arg Arg Gln Glu Glu Gln 
145                 150                 155                 160 
Gln Arg His Arg Pro Ser Pro Trp Arg Val Leu Tyr Asn Leu Ile Met 
                165                 170                 175     
Gly Leu Leu Pro Leu Pro Arg Gly His Arg Ala Pro Glu Met Glu Pro 
            180                 185                 190         
Asn 
    

