                         SEQUENCE LISTING

<110>  Almac Discovery Limited
 
<120>  ROR1-specific varient antigen binding molecules

<130>  P136723WO

<150>  2020154.7
<151>  2020-12-18

<160>  205   

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1: B1, 1E5, 1B11, C3CP, 1G12,G5CP, 1G9, 1H8, 1B6, 1F10, 1G1, 
       G3CP

<400>  1

Gly Ala Asn Tyr Gly Leu Ala Ala 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1: 1E2

<400>  2

Gly Ala Asn Tyr Asp Leu Ser Ala 
1               5               


<210>  3
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1: 2G5, 2F4, G11CP, E6CP, A10CP

<400>  3

Gly Ala Asn Tyr Gly Leu Ser Ala 
1               5               


<210>  4
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1: B6CP, F2CP, D9CP

<400>  4

Gly Ala Asn Tyr Asp Leu Ala Ala 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1: G4's

<400>  5

Asp Ala Asn Tyr Gly Leu Ala Ala 
1               5               


<210>  6
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence: HV2

<400>  6

Ser Ser Asn Gln Glu Arg Ile Ser Ile Ser 
1               5                   10  


<210>  7
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence: HV2

<400>  7

Ser Ser Asn Lys Glu Arg Ile Ser Ile Ser 
1               5                   10  


<210>  8
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence: HV4

<400>  8

Asn Lys Arg Thr Met 
1               5   


<210>  9
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence: HV4

<400>  9

Asn Lys Gly Thr Met 
1               5   


<210>  10
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3: B1, G11CP, D9CP

<400>  10

Tyr Pro Trp Gly Ala Gly Ala Pro Trp Leu Val Gln Trp Tyr 
1               5                   10                  


<210>  11
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3: 1E2

<400>  11

Tyr Pro Ser Gly Ala Gly Ala Pro Arg Pro Val Gln Trp Tyr 
1               5                   10                  


<210>  12
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3: 1E5

<400>  12

Tyr Pro Trp Gly Ala Gly Ala Pro Cys Leu Val Gln Trp Tyr 
1               5                   10                  


<210>  13
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3: 1B11

<400>  13

Tyr Pro Trp Gly Ala Gly Ala Pro Arg Leu Val Gln Trp Tyr 
1               5                   10                  


<210>  14
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3: C3CP

<400>  14

Tyr Pro Trp Gly Ala Gly Ala Pro Arg Gln Val Gln Trp Tyr 
1               5                   10                  


<210>  15
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3: 2G5, 1G12

<400>  15

Tyr Pro Trp Gly Ala Gly Ala Pro Arg Ser Val Gln Trp Tyr 
1               5                   10                  


<210>  16
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3: G5CP

<400>  16

Tyr Pro Trp Gly Ala Gly Ala Pro Ser Leu Val Gln Trp Tyr 
1               5                   10                  


<210>  17
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3: 2F4

<400>  17

Tyr Pro Trp Gly Ala Gly Ala Pro Ser Asn Val Gln Trp Tyr 
1               5                   10                  


<210>  18
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3: 1G9

<400>  18

Tyr Pro Trp Gly Ala Gly Ala Pro Ser Gln Val Gln Trp Tyr 
1               5                   10                  


<210>  19
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3: 1H8

<400>  19

Tyr Pro Trp Gly Ala Gly Ala Pro Ser Ser Val Gln Trp Tyr 
1               5                   10                  


<210>  20
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3: G3CP/G3CPG4 lacking L to N mutation

<400>  20

Tyr Pro Trp Gly Ala Gly Ala Pro Tyr Leu Val Gln Trp Tyr 
1               5                   10                  


<210>  21
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3: 1F10, E6CP, F2CP

<400>  21

Tyr Pro Trp Gly Ala Gly Ala Pro Trp Gln Val Gln Trp Tyr 
1               5                   10                  


<210>  22
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3: B6CP, 1G1, A10CP

<400>  22

Tyr Pro Trp Gly Ala Gly Ala Pro Trp Ser Val Gln Trp Tyr 
1               5                   10                  


<210>  23
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3: CDR3: G3CP and G3CPG4

<400>  23

Tyr Pro Trp Gly Ala Gly Ala Pro Tyr Asn Val Gln Trp Tyr 
1               5                   10                  


<210>  24
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3: G3CP/G3CPG4 lacking W to Y mutation i.e. 1B6

<400>  24

Tyr Pro Trp Gly Ala Gly Ala Pro Trp Asn Val Gln Trp Tyr 
1               5                   10                  


<210>  25
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1: AE3 DeltaSer

<400>  25

Gly Thr Arg Tyr Gly Leu Tyr Ser 
1               5               


<210>  26
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1: AE3.S

<400>  26

Gly Thr Arg Tyr Gly Leu Tyr Ser Ser 
1               5                   


<210>  27
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1: NAC6 DeltaSer

<400>  27

Asp Thr Arg Tyr Ala Leu Tyr Ser 
1               5               


<210>  28
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1: NAC6.S

<400>  28

Asp Thr Arg Tyr Ala Leu Tyr Ser Ser 
1               5                   


<210>  29
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1: NAG8 DeltaSer

<400>  29

Gly Thr Lys Tyr Gly Leu Tyr Ala 
1               5               


<210>  30
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1: NAG8.S, AF7.S

<400>  30

Gly Thr Lys Tyr Gly Leu Tyr Ala Ser 
1               5                   


<210>  31
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  HV2: AE3

<400>  31

Ser Ser Asp Glu Glu Arg Ile Ser Ile Ser 
1               5                   10  


<210>  32
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  HV2: NAC6

<400>  32

Ser Thr Asp Glu Glu Arg Ile Ser Ile Gly 
1               5                   10  


<210>  33
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  HV2: NAG8

<400>  33

Ser Pro Asn Lys Asp Arg Met Ile Ile Gly 
1               5                   10  


<210>  34
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  HV2: AF7

<400>  34

Ser Thr Asp Lys Glu Arg Ile Ile Ile Gly 
1               5                   10  


<210>  35
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  HV4: AE3

<400>  35

Asn Lys Gly Thr Lys 
1               5   


<210>  36
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  HV4: NAC6

<400>  36

Asn Lys Gly Ser Lys 
1               5   


<210>  37
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  HV4: NAG8

<400>  37

Asn Asn Gly Thr Lys 
1               5   


<210>  38
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  HV4: AF7

<400>  38

Asn Asn Arg Ser Lys 
1               5   


<210>  39
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3: PRA1 variants

<400>  39

Arg Glu Ala Arg His Pro Trp Leu Arg Gln Trp Tyr 
1               5                   10          


<210>  40
<211>  25
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence: FW1

<400>  40

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Val Thr 
            20                  25  


<210>  41
<211>  25
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence: FW1

<400>  41

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr 
            20                  25  


<210>  42
<211>  25
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence: FW1

<400>  42

Ala Ser Val Thr Gln Ser Pro Arg Ser Ala Ser Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Thr Cys Arg Val Thr 
            20                  25  


<210>  43
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequnce: FW2

<400>  43

Thr Tyr Trp Tyr Arg Lys Asn Pro Gly 
1               5                   


<210>  44
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence: FW3a

<400>  44

Gly Arg Tyr Val Glu Ser Val 
1               5           


<210>  45
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence: FW3a

<400>  45

Gly Arg Tyr Ser Glu Ser Val 
1               5           


<210>  46
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence: FW3b

<400>  46

Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr 
1               5                   10                  15      


Tyr Tyr Cys Arg Ala 
            20      


<210>  47
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence: FW3b

<400>  47

Ser Phe Ser Leu Arg Ile Ser Ser Leu Thr Val Glu Asp Ser Ala Thr 
1               5                   10                  15      


Tyr Tyr Cys Lys Ala 
            20      


<210>  48
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence: FW4

<400>  48

Asp Gly Ala Gly Thr Val Leu Thr Val Asn 
1               5                   10  


<210>  49
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence: FW4

<400>  49

Asp Gly Ala Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  50
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  G3CP

<400>  50

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Val Thr Gly Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Tyr Asn Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn 
            100                 105                 


<210>  51
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  B1G4

<400>  51

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Met 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Tyr Pro Trp Gly Ala Gly Ala Pro Trp Leu Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  52
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  1E2

<400>  52

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Val Thr Gly Ala Asn Tyr Asp Leu Ser 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Ser Gly Ala Gly Ala Pro Arg Pro Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn 
            100                 105                 


<210>  53
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  1E5

<400>  53

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Val Thr Gly Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Cys Leu Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn 
            100                 105                 


<210>  54
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  1B11

<400>  54

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Val Thr Gly Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Arg Leu Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn 
            100                 105                 


<210>  55
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  C3CP

<400>  55

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Val Thr Gly Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Arg Gln Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn 
            100                 105                 


<210>  56
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  2G5

<400>  56

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Val Thr Gly Ala Asn Tyr Gly Leu Ser 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Arg Ser Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn 
            100                 105                 


<210>  57
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  1G12

<400>  57

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Val Thr Gly Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Arg Ser Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn 
            100                 105                 


<210>  58
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  G5CP

<400>  58

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Val Thr Gly Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Ser Leu Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn 
            100                 105                 


<210>  59
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  2F4

<400>  59

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Val Thr Gly Ala Asn Tyr Gly Leu Ser 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Ser Asn Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn 
            100                 105                 


<210>  60
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  1G9

<400>  60

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Val Thr Gly Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Ser Gln Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn 
            100                 105                 


<210>  61
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  1H8

<400>  61

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Val Thr Gly Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Ser Ser Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn 
            100                 105                 


<210>  62
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  G11CP

<400>  62

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Val Thr Gly Ala Asn Tyr Gly Leu Ser 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Trp Leu Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn 
            100                 105                 


<210>  63
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  D9CP

<400>  63

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Val Thr Gly Ala Asn Tyr Asp Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Trp Leu Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn 
            100                 105                 


<210>  64
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  1B6

<400>  64

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Val Thr Gly Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Trp Asn Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn 
            100                 105                 


<210>  65
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  1F10

<400>  65

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Val Thr Gly Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Trp Gln Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn 
            100                 105                 


<210>  66
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  E6CP

<400>  66

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Val Thr Gly Ala Asn Tyr Gly Leu Ser 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Trp Gln Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn 
            100                 105                 


<210>  67
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  F2CP

<400>  67

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Val Thr Gly Ala Asn Tyr Asp Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Trp Gln Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn 
            100                 105                 


<210>  68
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  B6CP

<400>  68

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Val Thr Gly Ala Asn Tyr Asp Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Trp Ser Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn 
            100                 105                 


<210>  69
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  1G1

<400>  69

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Val Thr Gly Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Trp Ser Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn 
            100                 105                 


<210>  70
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  A10CP

<400>  70

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Val Thr Gly Ala Asn Tyr Gly Leu Ser 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Trp Ser Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn 
            100                 105                 


<210>  71
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  G3CP G4

<400>  71

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Met 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Tyr Pro Trp Gly Ala Gly Ala Pro Tyr Asn Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  72
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  G3CP V15

<400>  72

Ala Ser Val Thr Gln Ser Pro Arg Ser Ala Ser Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Thr Cys Arg Val Thr Gly Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Ser Ser Leu Thr Val Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Tyr Asn Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Gln Gly Thr Lys Leu Glu Val Lys 
            100                 105                 


<210>  73
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  1H8 G4

<400>  73

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Met 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Tyr Pro Trp Gly Ala Gly Ala Pro Ser Ser Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  74
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  1H8 V15

<400>  74

Ala Ser Val Thr Gln Ser Pro Arg Ser Ala Ser Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Thr Cys Arg Val Thr Gly Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Ser Ser Leu Thr Val Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Ser Ser Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Gln Gly Thr Lys Leu Glu Val Lys 
            100                 105                 


<210>  75
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  C3CP G4

<400>  75

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Met 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Tyr Pro Trp Gly Ala Gly Ala Pro Arg Gln Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  76
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  C3CP V15

<400>  76

Ala Ser Val Thr Gln Ser Pro Arg Ser Ala Ser Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Thr Cys Arg Val Thr Gly Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Ser Ser Leu Thr Val Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Arg Gln Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Gln Gly Thr Lys Leu Glu Val Lys 
            100                 105                 


<210>  77
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  P3A1 G1 AE3

<400>  77

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Gly Thr Arg Tyr Gly Leu Tyr 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asp Glu Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln Trp 
                85                  90                  95      


Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  78
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  P3A1 G1 AE3.S

<400>  78

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Gly Thr Arg Tyr Gly Leu Tyr 
            20                  25                  30          


Ser Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asp Glu Glu 
        35                  40                  45              


Arg Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr 
    50                  55                  60                  


Lys Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala 
65                  70                  75                  80  


Thr Tyr Tyr Cys Arg Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln 
                85                  90                  95      


Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  79
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  P3A1 G1 NAC6

<400>  79

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Arg Tyr Ala Leu Tyr 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Thr Asp Glu Glu Arg 
        35                  40                  45              


Ile Ser Ile Gly Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Ser Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln Trp 
                85                  90                  95      


Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  80
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  P3A1 G1 NAC6.S

<400>  80

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Arg Tyr Ala Leu Tyr 
            20                  25                  30          


Ser Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Thr Asp Glu Glu 
        35                  40                  45              


Arg Ile Ser Ile Gly Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Ser 
    50                  55                  60                  


Lys Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala 
65                  70                  75                  80  


Thr Tyr Tyr Cys Arg Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln 
                85                  90                  95      


Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  81
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  P3A1 G1 NAG8

<400>  81

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Gly Thr Lys Tyr Gly Leu Tyr 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Pro Asn Lys Asp Arg 
        35                  40                  45              


Met Ile Ile Gly Gly Arg Tyr Ser Glu Ser Val Asn Asn Gly Thr Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln Trp 
                85                  90                  95      


Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  82
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  P3A1 G1 NAG8.S

<400>  82

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Gly Thr Lys Tyr Gly Leu Tyr 
            20                  25                  30          


Ala Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Pro Asn Lys Asp 
        35                  40                  45              


Arg Met Ile Ile Gly Gly Arg Tyr Ser Glu Ser Val Asn Asn Gly Thr 
    50                  55                  60                  


Lys Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala 
65                  70                  75                  80  


Thr Tyr Tyr Cys Arg Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln 
                85                  90                  95      


Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  83
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  P3A1 G1 AF7.S

<400>  83

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Gly Thr Lys Tyr Gly Leu Tyr 
            20                  25                  30          


Ala Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Thr Asp Lys Glu 
        35                  40                  45              


Arg Ile Ile Ile Gly Gly Arg Tyr Ser Glu Ser Val Asn Asn Arg Ser 
    50                  55                  60                  


Lys Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala 
65                  70                  75                  80  


Thr Tyr Tyr Cys Arg Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln 
                85                  90                  95      


Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  84
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence: FW3b

<400>  84

Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
1               5                   10                  15      


Tyr Tyr Cys Lys Ala 
            20      


<210>  85
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence: FW4

<400>  85

Asp Gly Gln Gly Thr Lys Leu Glu Val Lys 
1               5                   10  


<210>  86
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker: [G4S]3

<400>  86

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  87
<211>  25
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker: [G4S]5

<400>  87

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  88
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker

<400>  88

Pro Gly Val Gln Pro Ser Pro 
1               5           


<210>  89
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker

<400>  89

Pro Gly Val Gln Pro Ser Pro Gly Gly Gly Gly Ser 
1               5                   10          


<210>  90
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker

<400>  90

Pro Gly Val Gln Pro Ala Pro Gly Gly Gly Gly Ser 
1               5                   10          


<210>  91
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linear peptide sequence

<400>  91

Tyr Met Glu Ser Leu His Met Gln Gly Glu Ile Glu Asn Gln Ile 
1               5                   10                  15  


<210>  92
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linear peptide sequence

<400>  92

Cys Gln Pro Trp Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala 
1               5                   10                  15      


Leu Arg Phe Pro 
            20  


<210>  93
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linear peptide sequence

<400>  93

Arg Ser Thr Ile Tyr Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr 
1               5                   10                  15      


Thr Asp Thr Gly Tyr Phe Gln 
            20              


<210>  94
<211>  36
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linear peptide sequence

<400>  94

Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser Ser Thr Gly Val 
1               5                   10                  15      


Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser Pro Gly Tyr Ser 
            20                  25                  30          


Asp Glu Tyr Glu 
        35      


<210>  95
<211>  103
<212>  PRT
<213>  artificial sequence

<220>
<223>  BA11

<400>  95

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Ser Tyr Pro Leu Tyr 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys Glu Gln 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Met Ser Thr Asn Ile Trp Thr Gly Asp Gly Ala 
                85                  90                  95      


Gly Thr Lys Val Glu Ile Lys 
            100             


<210>  96
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker: Wobbe-G5S

<400>  96

Pro Gly Val Gln Pro Ser Pro Gly Gly Gly Gly Gly Ser 
1               5                   10              


<210>  97
<211>  25
<212>  PRT
<213>  artificial sequence

<220>
<223>  Cys containing C-terminal tag

<400>  97

Gln Ala Cys Lys Ala His His His His His His Gly Ala Glu Phe Glu 
1               5                   10                  15      


Gln Lys Leu Ile Ser Glu Glu Asp Leu 
            20                  25  


<210>  98
<211>  25
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence: C-terminal tag

<400>  98

Gln Ala Ser Gly Ala His His His His His His Gly Ala Glu Phe Glu 
1               5                   10                  15      


Gln Lys Leu Ile Ser Glu Glu Asp Leu 
            20                  25  


<210>  99
<211>  25
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence: C-terminal tag

<400>  99

Gln Ala Cys Gly Ala His His His His His His Gly Ala Glu Phe Glu 
1               5                   10                  15      


Gln Lys Leu Ile Ser Glu Glu Asp Leu 
            20                  25  


<210>  100
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence: C-terminal tag

<400>  100

Ala Ala Ala His His His His His His Gly Ala Glu Phe Glu Gln Lys 
1               5                   10                  15      


Leu Ile Ser Glu Glu Asp Leu 
            20              


<210>  101
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence: C-terminal tag

<400>  101

Ala Cys Ala His His His His His His Gly Ala Glu Phe Glu Gln Lys 
1               5                   10                  15      


Leu Ile Ser Glu Glu Asp Leu 
            20              


<210>  102
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence: C-terminal tag

<400>  102

Gln Ala Ser Gly Ala His His His His His His 
1               5                   10      


<210>  103
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence: C-terminal tag

<400>  103

Gln Ala Cys Gly Ala His His His His His His 
1               5                   10      


<210>  104
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence: C-terminal tag

<400>  104

Gln Ala Cys Lys Ala His His His His His His 
1               5                   10      


<210>  105
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence: C-terminal tag

<400>  105

Ala Ala Ala His His His His His His 
1               5                   


<210>  106
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence: C-terminal tag

<400>  106

Ala Cys Ala His His His His His His 
1               5                   


<210>  107
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence: C-terminal tag

<400>  107

Gln Ala Ser Gly Ala 
1               5   


<210>  108
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence: C-terminal tag

<400>  108

Gln Ala Cys Gly Ala 
1               5   


<210>  109
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence: C-terminal tag

<400>  109

Gln Ala Cys Lys Ala 
1               5   


<210>  110
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence: C-terminal tag

<400>  110

Ala Cys Ala 
1           


<210>  111
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence: C-terminal tag

<400>  111

Ser Ala Pro Ser Ala 
1               5   


<210>  112
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  C-terminal tag with c-Myc sequence

<400>  112

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  113
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  B1

<400>  113

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Val Thr Gly Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Trp Leu Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn 
            100                 105                 


<210>  114
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  P3A1 G1

<400>  114

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Ser Tyr Gly Leu Tyr 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys Glu Gln 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln Trp 
                85                  90                  95      


Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  115
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  B1V15

<400>  115

Ala Ser Val Thr Gln Ser Pro Arg Ser Ala Ser Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Thr Cys Arg Val Thr Gly Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Ser Ser Leu Thr Val Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Trp Leu Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Gln Gly Thr Lys Leu Glu Val Lys 
            100                 105                 


<210>  116
<211>  35
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker: [G4S]7

<400>  116

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser 
        35  


<210>  117
<211>  368
<212>  PRT
<213>  artificial sequence

<220>
<223>  B1-G4-[WGM]-CD3

<400>  117

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Met 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Tyr Pro Trp Gly Ala Gly Ala Pro Trp Leu Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Pro Gly Val 
            100                 105                 110         


Gln Pro Ala Pro Gly Gly Gly Gly Ser Asp Ile Lys Leu Gln Gln Ser 
        115                 120                 125             


Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
    130                 135                 140                 


Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln 
145                 150                 155                 160 


Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg 
                165                 170                 175     


Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr 
            180                 185                 190         


Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr 
        195                 200                 205             


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His 
    210                 215                 220                 


Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
                245                 250                 255     


Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu 
            260                 265                 270         


Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asn 
        275                 280                 285             


Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp 
    290                 295                 300                 


Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe Ser Gly Ser Gly 
305                 310                 315                 320 


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp 
                325                 330                 335     


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe 
            340                 345                 350         


Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser His His His His His His 
        355                 360                 365             


<210>  118
<211>  368
<212>  PRT
<213>  artificial sequence

<220>
<223>  G3CP-[WGM]-CD3

<400>  118

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Val Thr Gly Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Tyr Asn Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn Pro Gly Val 
            100                 105                 110         


Gln Pro Ala Pro Gly Gly Gly Gly Ser Asp Ile Lys Leu Gln Gln Ser 
        115                 120                 125             


Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
    130                 135                 140                 


Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln 
145                 150                 155                 160 


Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg 
                165                 170                 175     


Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr 
            180                 185                 190         


Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr 
        195                 200                 205             


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His 
    210                 215                 220                 


Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
                245                 250                 255     


Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu 
            260                 265                 270         


Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asn 
        275                 280                 285             


Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp 
    290                 295                 300                 


Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe Ser Gly Ser Gly 
305                 310                 315                 320 


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp 
                325                 330                 335     


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe 
            340                 345                 350         


Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser His His His His His His 
        355                 360                 365             


<210>  119
<211>  368
<212>  PRT
<213>  artificial sequence

<220>
<223>  G3CPG4-[WGM]-CD3

<400>  119

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Met 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Tyr Pro Trp Gly Ala Gly Ala Pro Tyr Asn Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Pro Gly Val 
            100                 105                 110         


Gln Pro Ala Pro Gly Gly Gly Gly Ser Asp Ile Lys Leu Gln Gln Ser 
        115                 120                 125             


Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
    130                 135                 140                 


Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln 
145                 150                 155                 160 


Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg 
                165                 170                 175     


Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr 
            180                 185                 190         


Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr 
        195                 200                 205             


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His 
    210                 215                 220                 


Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
                245                 250                 255     


Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu 
            260                 265                 270         


Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asn 
        275                 280                 285             


Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp 
    290                 295                 300                 


Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe Ser Gly Ser Gly 
305                 310                 315                 320 


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp 
                325                 330                 335     


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe 
            340                 345                 350         


Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser His His His His His His 
        355                 360                 365             


<210>  120
<211>  366
<212>  PRT
<213>  artificial sequence

<220>
<223>  P3A1G1AE3-[WGM]-CD3

<400>  120

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Gly Thr Arg Tyr Gly Leu Tyr 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asp Glu Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln Trp 
                85                  90                  95      


Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Pro Gly Val Gln Pro 
            100                 105                 110         


Ala Pro Gly Gly Gly Gly Ser Asp Ile Lys Leu Gln Gln Ser Gly Ala 
        115                 120                 125             


Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Thr Ser 
    130                 135                 140                 


Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro 
145                 150                 155                 160 


Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr 
                165                 170                 175     


Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp 
            180                 185                 190         


Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu 
        195                 200                 205             


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys 
    210                 215                 220                 


Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
                245                 250                 255     


Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val 
            260                 265                 270         


Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr 
        275                 280                 285             


Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser 
    290                 295                 300                 


Lys Val Ala Ser Gly Val Pro Tyr Arg Phe Ser Gly Ser Gly Ser Gly 
305                 310                 315                 320 


Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala 
                325                 330                 335     


Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Ala 
            340                 345                 350         


Gly Thr Lys Leu Glu Leu Lys Ser His His His His His His 
        355                 360                 365     


<210>  121
<211>  476
<212>  PRT
<213>  artificial sequence

<220>
<223>  B1G4-[WGM]-BA11-[G4S]-CD3

<400>  121

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Met 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Tyr Pro Trp Gly Ala Gly Ala Pro Trp Leu Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Pro Gly Val 
            100                 105                 110         


Gln Pro Ala Pro Gly Gly Gly Gly Ser Thr Arg Val Asp Gln Ser Pro 
        115                 120                 125             


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Val 
    130                 135                 140                 


Leu Thr Asp Thr Ser Tyr Pro Leu Tyr Ser Thr Tyr Trp Tyr Arg Lys 
145                 150                 155                 160 


Asn Pro Gly Ser Ser Asn Lys Glu Gln Ile Ser Ile Ser Gly Arg Tyr 
                165                 170                 175     


Ser Glu Ser Val Asn Lys Gly Thr Lys Ser Phe Thr Leu Thr Ile Ser 
            180                 185                 190         


Ser Leu Gln Pro Glu Asp Ser Ala Thr Tyr Tyr Cys Arg Ala Met Ser 
        195                 200                 205             


Thr Asn Ile Trp Thr Gly Asp Gly Ala Gly Thr Lys Val Glu Ile Lys 
    210                 215                 220                 


Gly Gly Gly Gly Ser Asp Ile Lys Leu Gln Gln Ser Gly Ala Glu Leu 
225                 230                 235                 240 


Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr 
                245                 250                 255     


Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln 
            260                 265                 270         


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn 
        275                 280                 285             


Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser 
    290                 295                 300                 


Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser 
305                 310                 315                 320 


Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp 
                325                 330                 335     


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly 
            340                 345                 350         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr 
        355                 360                 365             


Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
    370                 375                 380                 


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln 
385                 390                 395                 400 


Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val 
                405                 410                 415     


Ala Ser Gly Val Pro Tyr Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
            420                 425                 430         


Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr 
        435                 440                 445             


Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr 
    450                 455                 460                 


Lys Leu Glu Leu Lys Ser His His His His His His 
465                 470                 475     


<210>  122
<211>  476
<212>  PRT
<213>  artificial sequence

<220>
<223>  G3CP[WGM]BA11-[G4S]-CD3

<400>  122

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Val Thr Gly Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Tyr Asn Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn Pro Gly Val 
            100                 105                 110         


Gln Pro Ala Pro Gly Gly Gly Gly Ser Thr Arg Val Asp Gln Ser Pro 
        115                 120                 125             


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Val 
    130                 135                 140                 


Leu Thr Asp Thr Ser Tyr Pro Leu Tyr Ser Thr Tyr Trp Tyr Arg Lys 
145                 150                 155                 160 


Asn Pro Gly Ser Ser Asn Lys Glu Gln Ile Ser Ile Ser Gly Arg Tyr 
                165                 170                 175     


Ser Glu Ser Val Asn Lys Gly Thr Lys Ser Phe Thr Leu Thr Ile Ser 
            180                 185                 190         


Ser Leu Gln Pro Glu Asp Ser Ala Thr Tyr Tyr Cys Arg Ala Met Ser 
        195                 200                 205             


Thr Asn Ile Trp Thr Gly Asp Gly Ala Gly Thr Lys Val Glu Ile Lys 
    210                 215                 220                 


Gly Gly Gly Gly Ser Asp Ile Lys Leu Gln Gln Ser Gly Ala Glu Leu 
225                 230                 235                 240 


Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr 
                245                 250                 255     


Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln 
            260                 265                 270         


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn 
        275                 280                 285             


Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser 
    290                 295                 300                 


Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser 
305                 310                 315                 320 


Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp 
                325                 330                 335     


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly 
            340                 345                 350         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr 
        355                 360                 365             


Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
    370                 375                 380                 


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln 
385                 390                 395                 400 


Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val 
                405                 410                 415     


Ala Ser Gly Val Pro Tyr Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
            420                 425                 430         


Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr 
        435                 440                 445             


Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr 
    450                 455                 460                 


Lys Leu Glu Leu Lys Ser His His His His His His 
465                 470                 475     


<210>  123
<211>  476
<212>  PRT
<213>  artificial sequence

<220>
<223>  G3CPG4[WGM]BA11-[G4S]-CD3

<400>  123

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Met 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Tyr Pro Trp Gly Ala Gly Ala Pro Tyr Asn Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Pro Gly Val 
            100                 105                 110         


Gln Pro Ala Pro Gly Gly Gly Gly Ser Thr Arg Val Asp Gln Ser Pro 
        115                 120                 125             


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Val 
    130                 135                 140                 


Leu Thr Asp Thr Ser Tyr Pro Leu Tyr Ser Thr Tyr Trp Tyr Arg Lys 
145                 150                 155                 160 


Asn Pro Gly Ser Ser Asn Lys Glu Gln Ile Ser Ile Ser Gly Arg Tyr 
                165                 170                 175     


Ser Glu Ser Val Asn Lys Gly Thr Lys Ser Phe Thr Leu Thr Ile Ser 
            180                 185                 190         


Ser Leu Gln Pro Glu Asp Ser Ala Thr Tyr Tyr Cys Arg Ala Met Ser 
        195                 200                 205             


Thr Asn Ile Trp Thr Gly Asp Gly Ala Gly Thr Lys Val Glu Ile Lys 
    210                 215                 220                 


Gly Gly Gly Gly Ser Asp Ile Lys Leu Gln Gln Ser Gly Ala Glu Leu 
225                 230                 235                 240 


Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr 
                245                 250                 255     


Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln 
            260                 265                 270         


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn 
        275                 280                 285             


Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser 
    290                 295                 300                 


Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser 
305                 310                 315                 320 


Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp 
                325                 330                 335     


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly 
            340                 345                 350         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr 
        355                 360                 365             


Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
    370                 375                 380                 


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln 
385                 390                 395                 400 


Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val 
                405                 410                 415     


Ala Ser Gly Val Pro Tyr Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
            420                 425                 430         


Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr 
        435                 440                 445             


Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr 
    450                 455                 460                 


Lys Leu Glu Leu Lys Ser His His His His His His 
465                 470                 475     


<210>  124
<211>  474
<212>  PRT
<213>  artificial sequence

<220>
<223>  P3A1G1AE3[WGM]BA11-[G4S]-CD3

<400>  124

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Gly Thr Arg Tyr Gly Leu Tyr 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asp Glu Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln Trp 
                85                  90                  95      


Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Pro Gly Val Gln Pro 
            100                 105                 110         


Ala Pro Gly Gly Gly Gly Ser Thr Arg Val Asp Gln Ser Pro Ser Ser 
        115                 120                 125             


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Val Leu Thr 
    130                 135                 140                 


Asp Thr Ser Tyr Pro Leu Tyr Ser Thr Tyr Trp Tyr Arg Lys Asn Pro 
145                 150                 155                 160 


Gly Ser Ser Asn Lys Glu Gln Ile Ser Ile Ser Gly Arg Tyr Ser Glu 
                165                 170                 175     


Ser Val Asn Lys Gly Thr Lys Ser Phe Thr Leu Thr Ile Ser Ser Leu 
            180                 185                 190         


Gln Pro Glu Asp Ser Ala Thr Tyr Tyr Cys Arg Ala Met Ser Thr Asn 
        195                 200                 205             


Ile Trp Thr Gly Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Gly Gly 
    210                 215                 220                 


Gly Gly Ser Asp Ile Lys Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg 
225                 230                 235                 240 


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe 
                245                 250                 255     


Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
            260                 265                 270         


Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn 
        275                 280                 285             


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser 
    290                 295                 300                 


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
305                 310                 315                 320 


Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp 
                325                 330                 335     


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
            340                 345                 350         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser 
        355                 360                 365             


Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys 
    370                 375                 380                 


Arg Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser 
385                 390                 395                 400 


Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser 
                405                 410                 415     


Gly Val Pro Tyr Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
            420                 425                 430         


Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
        435                 440                 445             


Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu 
    450                 455                 460                 


Glu Leu Lys Ser His His His His His His 
465                 470                 


<210>  125
<211>  480
<212>  PRT
<213>  artificial sequence

<220>
<223>  P3A1[WGM]G3CP-[G4S]-CD3

<400>  125

Thr Arg Val Asp Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Thr Asp Thr Ser Tyr Gly Leu Tyr 
            20                  25                  30          


Ser Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Thr Asp Trp Glu Arg 
        35                  40                  45              


Met Ser Ile Gly Gly Arg Tyr Val Glu Ser Val Asn Lys Gly Ala Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln Trp 
                85                  90                  95      


Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn Pro Gly Val Gln Pro 
            100                 105                 110         


Ala Pro Gly Gly Gly Gly Ser Ala Ser Val Asn Gln Thr Pro Arg Thr 
        115                 120                 125             


Ala Thr Lys Glu Thr Gly Glu Ser Leu Thr Ile Asn Cys Val Val Thr 
    130                 135                 140                 


Gly Ala Asn Tyr Gly Leu Ala Ala Thr Tyr Trp Tyr Arg Lys Asn Pro 
145                 150                 155                 160 


Gly Ser Ser Asn Gln Glu Arg Ile Ser Ile Ser Gly Arg Tyr Val Glu 
                165                 170                 175     


Ser Val Asn Lys Arg Thr Met Ser Phe Ser Leu Arg Ile Lys Asp Leu 
            180                 185                 190         


Thr Val Ala Asp Ser Ala Thr Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly 
        195                 200                 205             


Ala Gly Ala Pro Tyr Asn Val Gln Trp Tyr Asp Gly Ala Gly Thr Val 
    210                 215                 220                 


Leu Thr Val Asn Gly Gly Gly Gly Ser Asp Ile Lys Leu Gln Gln Ser 
225                 230                 235                 240 


Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
                245                 250                 255     


Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln 
            260                 265                 270         


Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg 
        275                 280                 285             


Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr 
    290                 295                 300                 


Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr 
305                 310                 315                 320 


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His 
                325                 330                 335     


Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            340                 345                 350         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        355                 360                 365             


Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu 
    370                 375                 380                 


Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asn 
385                 390                 395                 400 


Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp 
                405                 410                 415     


Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe Ser Gly Ser Gly 
            420                 425                 430         


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp 
        435                 440                 445             


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe 
    450                 455                 460                 


Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser His His His His His His 
465                 470                 475                 480 


<210>  126
<211>  480
<212>  PRT
<213>  artificial sequence

<220>
<223>  P3A1[WGM]G3CPG4-[G4S]-CD3

<400>  126

Thr Arg Val Asp Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Thr Asp Thr Ser Tyr Gly Leu Tyr 
            20                  25                  30          


Ser Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Thr Asp Trp Glu Arg 
        35                  40                  45              


Met Ser Ile Gly Gly Arg Tyr Val Glu Ser Val Asn Lys Gly Ala Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln Trp 
                85                  90                  95      


Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn Pro Gly Val Gln Pro 
            100                 105                 110         


Ala Pro Gly Gly Gly Gly Ser Thr Arg Val Asp Gln Ser Pro Ser Ser 
        115                 120                 125             


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Val Leu Thr 
    130                 135                 140                 


Asp Ala Asn Tyr Gly Leu Ala Ala Thr Tyr Trp Tyr Arg Lys Asn Pro 
145                 150                 155                 160 


Gly Ser Ser Asn Lys Glu Arg Ile Ser Ile Ser Gly Arg Tyr Ser Glu 
                165                 170                 175     


Ser Val Asn Lys Gly Thr Met Ser Phe Thr Leu Thr Ile Ser Ser Leu 
            180                 185                 190         


Gln Pro Glu Asp Ser Ala Thr Tyr Tyr Cys Arg Ala Tyr Pro Trp Gly 
        195                 200                 205             


Ala Gly Ala Pro Tyr Asn Val Gln Trp Tyr Asp Gly Ala Gly Thr Lys 
    210                 215                 220                 


Val Glu Ile Lys Gly Gly Gly Gly Ser Asp Ile Lys Leu Gln Gln Ser 
225                 230                 235                 240 


Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
                245                 250                 255     


Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln 
            260                 265                 270         


Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg 
        275                 280                 285             


Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr 
    290                 295                 300                 


Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr 
305                 310                 315                 320 


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His 
                325                 330                 335     


Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            340                 345                 350         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        355                 360                 365             


Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu 
    370                 375                 380                 


Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asn 
385                 390                 395                 400 


Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp 
                405                 410                 415     


Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe Ser Gly Ser Gly 
            420                 425                 430         


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp 
        435                 440                 445             


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe 
    450                 455                 460                 


Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser His His His His His His 
465                 470                 475                 480 


<210>  127
<211>  480
<212>  PRT
<213>  artificial sequence

<220>
<223>  P3A1G1AE3[WGM]G3CP-[G4S]-CD3

<400>  127

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Arg Tyr Ala Leu Tyr 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Thr Asp Glu Glu Arg 
        35                  40                  45              


Ile Ser Ile Gly Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Ser Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln Trp 
                85                  90                  95      


Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Pro Gly Val Gln Pro 
            100                 105                 110         


Ala Pro Gly Gly Gly Gly Ser Ala Ser Val Asn Gln Thr Pro Arg Thr 
        115                 120                 125             


Ala Thr Lys Glu Thr Gly Glu Ser Leu Thr Ile Asn Cys Val Val Thr 
    130                 135                 140                 


Gly Ala Asn Tyr Gly Leu Ala Ala Thr Tyr Trp Tyr Arg Lys Asn Pro 
145                 150                 155                 160 


Gly Ser Ser Asn Gln Glu Arg Ile Ser Ile Ser Gly Arg Tyr Val Glu 
                165                 170                 175     


Ser Val Asn Lys Arg Thr Met Ser Phe Ser Leu Arg Ile Lys Asp Leu 
            180                 185                 190         


Thr Val Ala Asp Ser Ala Thr Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly 
        195                 200                 205             


Ala Gly Ala Pro Tyr Asn Val Gln Trp Tyr Asp Gly Ala Gly Thr Val 
    210                 215                 220                 


Leu Thr Val Asn Gly Gly Gly Gly Ser Asp Ile Lys Leu Gln Gln Ser 
225                 230                 235                 240 


Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
                245                 250                 255     


Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln 
            260                 265                 270         


Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg 
        275                 280                 285             


Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr 
    290                 295                 300                 


Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr 
305                 310                 315                 320 


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His 
                325                 330                 335     


Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            340                 345                 350         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        355                 360                 365             


Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu 
    370                 375                 380                 


Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asn 
385                 390                 395                 400 


Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp 
                405                 410                 415     


Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe Ser Gly Ser Gly 
            420                 425                 430         


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp 
        435                 440                 445             


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe 
    450                 455                 460                 


Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser His His His His His His 
465                 470                 475                 480 


<210>  128
<211>  480
<212>  PRT
<213>  artificial sequence

<220>
<223>  P3A1G1AE3[WGM]G3CPG4-[G4S]-CD3

<400>  128

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Arg Tyr Ala Leu Tyr 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Thr Asp Glu Glu Arg 
        35                  40                  45              


Ile Ser Ile Gly Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Ser Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln Trp 
                85                  90                  95      


Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Pro Gly Val Gln Pro 
            100                 105                 110         


Ala Pro Gly Gly Gly Gly Ser Thr Arg Val Asp Gln Ser Pro Ser Ser 
        115                 120                 125             


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Val Leu Thr 
    130                 135                 140                 


Asp Ala Asn Tyr Gly Leu Ala Ala Thr Tyr Trp Tyr Arg Lys Asn Pro 
145                 150                 155                 160 


Gly Ser Ser Asn Lys Glu Arg Ile Ser Ile Ser Gly Arg Tyr Ser Glu 
                165                 170                 175     


Ser Val Asn Lys Gly Thr Met Ser Phe Thr Leu Thr Ile Ser Ser Leu 
            180                 185                 190         


Gln Pro Glu Asp Ser Ala Thr Tyr Tyr Cys Arg Ala Tyr Pro Trp Gly 
        195                 200                 205             


Ala Gly Ala Pro Tyr Asn Val Gln Trp Tyr Asp Gly Ala Gly Thr Lys 
    210                 215                 220                 


Val Glu Ile Lys Gly Gly Gly Gly Ser Asp Ile Lys Leu Gln Gln Ser 
225                 230                 235                 240 


Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
                245                 250                 255     


Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln 
            260                 265                 270         


Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg 
        275                 280                 285             


Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr 
    290                 295                 300                 


Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr 
305                 310                 315                 320 


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His 
                325                 330                 335     


Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            340                 345                 350         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        355                 360                 365             


Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu 
    370                 375                 380                 


Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asn 
385                 390                 395                 400 


Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp 
                405                 410                 415     


Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe Ser Gly Ser Gly 
            420                 425                 430         


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp 
        435                 440                 445             


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe 
    450                 455                 460                 


Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser His His His His His His 
465                 470                 475                 480 


<210>  129
<211>  483
<212>  PRT
<213>  artificial sequence

<220>
<223>  P3A1G1AE3[WGM]D3-[G4S]-CD3

<400>  129

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Arg Tyr Ala Leu Tyr 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Thr Asp Glu Glu Arg 
        35                  40                  45              


Ile Ser Ile Gly Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Ser Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln Trp 
                85                  90                  95      


Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Pro Gly Val Gln Pro 
            100                 105                 110         


Ala Pro Gly Gly Gly Gly Ser Ala Ser Val Asn Gln Thr Pro Arg Thr 
        115                 120                 125             


Ala Thr Lys Glu Thr Gly Glu Ser Leu Thr Ile Asn Cys Val Leu Thr 
    130                 135                 140                 


Asp Thr Ser Tyr Gly Leu Tyr Ser Thr Ser Trp Phe Arg Lys Asn Pro 
145                 150                 155                 160 


Gly Thr Thr Asp Trp Glu Arg Met Ser Ile Gly Gly Arg Tyr Val Glu 
                165                 170                 175     


Ser Val Asn Lys Arg Ala Lys Ser Phe Ser Leu Arg Ile Lys Asp Leu 
            180                 185                 190         


Thr Val Ala Asp Ser Ala Thr Tyr Tyr Cys Lys Ala Gln Ser Gly Met 
        195                 200                 205             


Ala Ile Ser Thr Gly Ser Gly His Gly Tyr Asn Trp Tyr Asp Gly Ala 
    210                 215                 220                 


Gly Thr Val Leu Thr Val Asn Gly Gly Gly Gly Ser Asp Ile Lys Leu 
225                 230                 235                 240 


Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met 
                245                 250                 255     


Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp 
            260                 265                 270         


Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn 
        275                 280                 285             


Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala 
    290                 295                 300                 


Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser 
305                 310                 315                 320 


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr 
                325                 330                 335     


Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            340                 345                 350         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser 
    370                 375                 380                 


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
385                 390                 395                 400 


Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp 
                405                 410                 415     


Ile Tyr Asp Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe Ser 
            420                 425                 430         


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
        435                 440                 445             


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro 
    450                 455                 460                 


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser His His His 
465                 470                 475                 480 


His His His 
            


<210>  130
<211>  243
<212>  PRT
<213>  artificial sequence

<220>
<223>  UCL OKT3 sequence (WO2019008379)

<400>  130

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser Val Glu Gly Gly Ser Gly Gly Ser Gly 
        115                 120                 125             


Gly Ser Gly Gly Ser Gly Gly Val Asp Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Arg Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Gln Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  131
<211>  243
<212>  PRT
<213>  artificial sequence

<220>
<223>  Harpoon ID20 (WO2016187594)

<400>  131

Asp Ile Lys Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Val Glu Gly Gly Ser Gly Gly Ser Gly 
        115                 120                 125             


Gly Ser Gly Gly Ser Gly Gly Val Asp Asp Ile Gln Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser 
                165                 170                 175     


Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser 
            180                 185                 190         


Gly Val Pro Tyr Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
        195                 200                 205             


Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Leu Lys 
            


<210>  132
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  DPK9

<400>  132

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Asn 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  133
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer 280

<400>  133
ctaccgtggc ccaggcggcc                                                   20


<210>  134
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer 287

<400>  134
ggtgatggtg ggcccctgag gcct                                              24


<210>  135
<211>  132
<212>  PRT
<213>  artificial sequence

<220>
<223>  P3A1 G1

<400>  135

Thr Arg Val Asp Gln Thr Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Ser Tyr Gly Leu Tyr 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys Glu Gln 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln Trp 
                85                  90                  95      


Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Gln Ala Ser Gly Ala 
            100                 105                 110         


His His His His His His Gly Ala Glu Phe Glu Gln Lys Leu Ile Ser 
        115                 120                 125             


Glu Glu Asp Leu 
    130         


<210>  136
<211>  133
<212>  PRT
<213>  artificial sequence

<220>
<223>  NAG8.S

<400>  136

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Gly Thr Lys Tyr Gly Leu Tyr 
            20                  25                  30          


Ala Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Pro Asn Lys Asp 
        35                  40                  45              


Arg Met Ile Ile Gly Gly Arg Tyr Ser Glu Ser Val Asn Asn Gly Thr 
    50                  55                  60                  


Lys Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala 
65                  70                  75                  80  


Thr Tyr Tyr Cys Arg Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln 
                85                  90                  95      


Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Gln Ala Ser Gly 
            100                 105                 110         


Ala His His His His His His Gly Ala Glu Phe Glu Gln Lys Leu Ile 
        115                 120                 125             


Ser Glu Glu Asp Leu 
    130             


<210>  137
<211>  133
<212>  PRT
<213>  artificial sequence

<220>
<223>  AC5.S

<400>  137

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Ser Tyr Gly Leu Tyr 
            20                  25                  30          


Ser Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys Glu 
        35                  40                  45              


Arg Met Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Ser 
    50                  55                  60                  


Lys Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala 
65                  70                  75                  80  


Thr Tyr Tyr Cys Arg Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln 
                85                  90                  95      


Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Gln Ala Ser Gly 
            100                 105                 110         


Ala His His His His His His Gly Ala Glu Phe Glu Gln Lys Leu Ile 
        115                 120                 125             


Ser Glu Glu Asp Leu 
    130             


<210>  138
<211>  133
<212>  PRT
<213>  artificial sequence

<220>
<223>  AG5.S

<400>  138

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Asn Tyr Ala Leu Tyr 
            20                  25                  30          


Ser Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Thr Asn Lys Glu 
        35                  40                  45              


Ser Met Ser Ile Gly Gly Arg Tyr Ser Glu Ser Val Asn Lys Arg Ser 
    50                  55                  60                  


Lys Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala 
65                  70                  75                  80  


Thr Tyr Tyr Cys Arg Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln 
                85                  90                  95      


Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Gln Ala Ser Gly 
            100                 105                 110         


Ala His His His His His His Gly Ala Glu Phe Glu Gln Lys Leu Ile 
        115                 120                 125             


Ser Glu Glu Asp Leu 
    130             


<210>  139
<211>  133
<212>  PRT
<213>  artificial sequence

<220>
<223>  AF1.S

<400>  139

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Ala Lys Tyr Gly Leu Tyr 
            20                  25                  30          


Ser Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Pro Asp Lys Glu 
        35                  40                  45              


Arg Ile Ile Asn Gly Gly Arg Tyr Ser Glu Ser Val Asn Asn Arg Thr 
    50                  55                  60                  


Lys Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala 
65                  70                  75                  80  


Thr Tyr Tyr Cys Arg Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln 
                85                  90                  95      


Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Gln Ala Ser Gly 
            100                 105                 110         


Ala His His His His His His Gly Ala Glu Phe Glu Gln Lys Leu Ile 
        115                 120                 125             


Ser Glu Glu Asp Leu 
    130             


<210>  140
<211>  133
<212>  PRT
<213>  artificial sequence

<220>
<223>  AB11.S

<400>  140

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Ala Arg Tyr Gly Leu Phe 
            20                  25                  30          


Ala Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Pro Asp Lys Asp 
        35                  40                  45              


Ser Ile Ser Ile Gly Gly Arg Tyr Ser Glu Ser Val Asn Lys Arg Ser 
    50                  55                  60                  


Lys Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala 
65                  70                  75                  80  


Thr Tyr Tyr Cys Arg Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln 
                85                  90                  95      


Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Gln Ala Ser Gly 
            100                 105                 110         


Ala His His His His His His Gly Ala Glu Phe Glu Gln Lys Leu Ile 
        115                 120                 125             


Ser Glu Glu Asp Leu 
    130             


<210>  141
<211>  133
<212>  PRT
<213>  artificial sequence

<220>
<223>  NAE1.S

<400>  141

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Gly Thr Lys Tyr Gly Leu Phe 
            20                  25                  30          


Ser Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asp Lys Glu 
        35                  40                  45              


Arg Ile Ser Ile Gly Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Pro 
    50                  55                  60                  


Lys Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala 
65                  70                  75                  80  


Thr Tyr Tyr Cys Arg Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln 
                85                  90                  95      


Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Gln Ala Ser Gly 
            100                 105                 110         


Ala His His His His His His Gly Ala Glu Phe Glu Gln Lys Leu Ile 
        115                 120                 125             


Ser Glu Glu Asp Leu 
    130             


<210>  142
<211>  133
<212>  PRT
<213>  artificial sequence

<220>
<223>  AA6.S

<400>  142

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Gly Thr Arg Tyr Gly Leu Tyr 
            20                  25                  30          


Ala Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Pro Asp Glu Glu 
        35                  40                  45              


Ser Met Ile Asn Gly Gly Arg Tyr Ser Glu Ser Val Asn Lys Arg Thr 
    50                  55                  60                  


Lys Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala 
65                  70                  75                  80  


Thr Tyr Tyr Cys Arg Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln 
                85                  90                  95      


Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Gln Ala Ser Gly 
            100                 105                 110         


Ala His His His His His His Gly Ala Glu Phe Glu Gln Lys Leu Ile 
        115                 120                 125             


Ser Glu Glu Asp Leu 
    130             


<210>  143
<211>  133
<212>  PRT
<213>  artificial sequence

<220>
<223>  AB7.S

<400>  143

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Lys Tyr Ala Leu Phe 
            20                  25                  30          


Ser Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Glu Glu 
        35                  40                  45              


Arg Ile Ser Ile Gly Gly Arg Tyr Ser Glu Ser Val Asn Asn Arg Thr 
    50                  55                  60                  


Lys Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala 
65                  70                  75                  80  


Thr Tyr Tyr Cys Arg Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln 
                85                  90                  95      


Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Gln Ala Ser Gly 
            100                 105                 110         


Ala His His His His His His Gly Ala Glu Phe Glu Gln Lys Leu Ile 
        115                 120                 125             


Ser Glu Glu Asp Leu 
    130             


<210>  144
<211>  133
<212>  PRT
<213>  artificial sequence

<220>
<223>  AF7.S

<400>  144

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Gly Thr Lys Tyr Gly Leu Tyr 
            20                  25                  30          


Ala Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Thr Asp Lys Glu 
        35                  40                  45              


Arg Ile Ile Ile Gly Gly Arg Tyr Ser Glu Ser Val Asn Asn Arg Ser 
    50                  55                  60                  


Lys Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala 
65                  70                  75                  80  


Thr Tyr Tyr Cys Arg Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln 
                85                  90                  95      


Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Gln Ala Ser Gly 
            100                 105                 110         


Ala His His His His His His Gly Ala Glu Phe Glu Gln Lys Leu Ile 
        115                 120                 125             


Ser Glu Glu Asp Leu 
    130             


<210>  145
<211>  232
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human IgG1 Fc (hFc)

<400>  145

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  146
<211>  356
<212>  PRT
<213>  artificial sequence

<220>
<223>  G3CP hFc(S239C+Y407T)

<400>  146

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Val Thr Gly Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Tyr Asn Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
        115                 120                 125             


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Cys Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Lys 
        355     


<210>  147
<211>  356
<212>  PRT
<213>  artificial sequence

<220>
<223>  G3CPG4 hFc(S239C+Y407T)

<400>  147

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Met 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Tyr Pro Trp Gly Ala Gly Ala Pro Tyr Asn Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
        115                 120                 125             


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Cys Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Lys 
        355     


<210>  148
<211>  354
<212>  PRT
<213>  artificial sequence

<220>
<223>  P3A1 hFc(S239C+T366Y)

<400>  148

Thr Arg Val Asp Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Thr Asp Thr Ser Tyr Gly Leu Tyr 
            20                  25                  30          


Ser Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Thr Asp Trp Glu Arg 
        35                  40                  45              


Met Ser Ile Gly Gly Arg Tyr Val Glu Ser Val Asn Lys Gly Ala Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln Trp 
                85                  90                  95      


Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp 
        115                 120                 125             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    130                 135                 140                 


Pro Cys Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
145                 150                 155                 160 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                165                 170                 175     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            180                 185                 190         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        195                 200                 205             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    210                 215                 220                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
225                 230                 235                 240 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                245                 250                 255     


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
            260                 265                 270         


Tyr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        275                 280                 285             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    290                 295                 300                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
305                 310                 315                 320 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                325                 330                 335     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            340                 345                 350         


Gly Lys 
        


<210>  149
<211>  241
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH-[G4S]3-VL

<400>  149

Asp Ile Lys Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile 
    130                 135                 140                 


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser 
                165                 170                 175     


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser Gly Val Pro 
            180                 185                 190         


Tyr Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
        195                 200                 205             


Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Ser Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
225                 230                 235                 240 


Ser 
    


<210>  150
<211>  245
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL-[G4S]3-VH

<400>  150

Met Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu 
65                  70                  75                  80  


Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro 
                85                  90                  95      


Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln 
        115                 120                 125             


Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Met Lys Ile Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val 
145                 150                 155                 160 


Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met Gly Leu Ile Asn Pro 
                165                 170                 175     


Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr 
            180                 185                 190         


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser 
        195                 200                 205             


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr 
    210                 215                 220                 


Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Thr 
225                 230                 235                 240 


Leu Thr Val Phe Ser 
                245 


<210>  151
<211>  380
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human ROR1-His (CHO)

<400>  151

Gln Glu Thr Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser 
1               5                   10                  15      


Trp Asn Ile Ser Ser Glu Leu Asn Lys Asp Ser Tyr Leu Thr Leu Asp 
            20                  25                  30          


Glu Pro Met Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu 
        35                  40                  45              


His Cys Lys Val Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp Phe Lys 
    50                  55                  60                  


Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Leu Ser Phe Arg Ser 
65                  70                  75                  80  


Thr Ile Tyr Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp 
                85                  90                  95      


Thr Gly Tyr Phe Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser 
            100                 105                 110         


Ser Thr Gly Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser 
        115                 120                 125             


Pro Gly Tyr Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr 
    130                 135                 140                 


Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met 
145                 150                 155                 160 


Glu Ser Leu His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala 
                165                 170                 175     


Phe Thr Met Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln 
            180                 185                 190         


Phe Ala Ile Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu 
        195                 200                 205             


Thr Ser Ser Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu 
    210                 215                 220                 


Ile Leu Glu Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser 
225                 230                 235                 240 


Asn Pro Met Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu 
                245                 250                 255     


Pro Gln Pro Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile 
            260                 265                 270         


Pro Met Ala Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr 
        275                 280                 285             


Gly Val Asp Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln 
    290                 295                 300                 


Cys Gln Pro Trp Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala 
305                 310                 315                 320 


Leu Arg Phe Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro 
                325                 330                 335     


Gly Asn Gln Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe 
            340                 345                 350         


Lys Ser Asp Leu Cys Asp Ile Pro Ala Cys Asp Ser Lys Asp Ser Lys 
        355                 360                 365             


Glu Lys Asn Lys Met Glu His His His His His His 
    370                 375                 380 


<210>  152
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human ROR1 (Ig domain)

<400>  152

Ser Glu Leu Asn Lys Asp Ser Tyr Leu Thr Leu Asp Glu Pro Met Asn 
1               5                   10                  15      


Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu His Cys Lys Val 
            20                  25                  30          


Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp Phe Lys Asn Asp Ala Pro 
        35                  40                  45              


Val Val Gln Glu Pro Arg Arg Leu Ser Phe Arg Ser Thr Ile Tyr Gly 
    50                  55                  60                  


Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp Thr Gly Tyr Phe 
65                  70                  75                  80  


Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser Ser Thr Gly Val 
                85                  90                  95      


Leu Phe Val Lys Ala Ala Ala His His His His His 
            100                 105             


<210>  153
<211>  380
<212>  PRT
<213>  artificial sequence

<220>
<223>  Mouse ROR1-His (CHO)

<400>  153

Gln Glu Thr Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser 
1               5                   10                  15      


Trp Asn Thr Ser Ser Glu Ile Asp Lys Gly Ser Tyr Leu Thr Leu Asp 
            20                  25                  30          


Glu Pro Met Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu 
        35                  40                  45              


His Cys Lys Val Ser Gly Asn Pro Pro Pro Ser Ile Arg Trp Phe Lys 
    50                  55                  60                  


Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Ile Ser Phe Arg Ala 
65                  70                  75                  80  


Thr Asn Tyr Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp 
                85                  90                  95      


Thr Gly Tyr Phe Gln Cys Val Ala Thr Asn Gly Lys Lys Val Val Ser 
            100                 105                 110         


Thr Thr Gly Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser 
        115                 120                 125             


Pro Gly Ser Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr 
    130                 135                 140                 


Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met 
145                 150                 155                 160 


Glu Ser Leu His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala 
                165                 170                 175     


Phe Thr Met Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln 
            180                 185                 190         


Phe Ala Ile Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu 
        195                 200                 205             


Thr Ser Ser Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu 
    210                 215                 220                 


Val Leu Glu Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser 
225                 230                 235                 240 


Asn Pro Met Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu 
                245                 250                 255     


Pro Gln Pro Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile 
            260                 265                 270         


Pro Met Ala Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr 
        275                 280                 285             


Gly Val Asp Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln 
    290                 295                 300                 


Cys Gln Pro Trp Asn Ser Gln Tyr Pro His Thr His Ser Phe Thr Ala 
305                 310                 315                 320 


Leu Arg Phe Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro 
                325                 330                 335     


Gly Asn Gln Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe 
            340                 345                 350         


Lys Ser Asp Leu Cys Asp Ile Pro Ala Cys Asp Ser Lys Asp Ser Lys 
        355                 360                 365             


Glu Lys Asn Lys Met Glu His His His His His His 
    370                 375                 380 


<210>  154
<211>  616
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human ROR1-Fc (CHO)

<400>  154

Gln Glu Thr Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser 
1               5                   10                  15      


Trp Asn Ile Ser Ser Glu Leu Asn Lys Asp Ser Tyr Leu Thr Leu Asp 
            20                  25                  30          


Glu Pro Met Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu 
        35                  40                  45              


His Cys Lys Val Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp Phe Lys 
    50                  55                  60                  


Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Leu Ser Phe Arg Ser 
65                  70                  75                  80  


Thr Ile Tyr Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp 
                85                  90                  95      


Thr Gly Tyr Phe Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser 
            100                 105                 110         


Ser Thr Gly Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser 
        115                 120                 125             


Pro Gly Tyr Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr 
    130                 135                 140                 


Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met 
145                 150                 155                 160 


Glu Ser Leu His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala 
                165                 170                 175     


Phe Thr Met Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln 
            180                 185                 190         


Phe Ala Ile Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu 
        195                 200                 205             


Thr Ser Ser Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu 
    210                 215                 220                 


Ile Leu Glu Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser 
225                 230                 235                 240 


Asn Pro Met Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu 
                245                 250                 255     


Pro Gln Pro Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile 
            260                 265                 270         


Pro Met Ala Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr 
        275                 280                 285             


Gly Val Asp Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln 
    290                 295                 300                 


Cys Gln Pro Trp Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala 
305                 310                 315                 320 


Leu Arg Phe Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro 
                325                 330                 335     


Gly Asn Gln Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe 
            340                 345                 350         


Lys Ser Asp Leu Cys Asp Ile Pro Ala Cys Asp Ser Lys Asp Ser Lys 
        355                 360                 365             


Glu Lys Asn Lys Met Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
385                 390                 395                 400 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                405                 410                 415     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            420                 425                 430         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        435                 440                 445             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    450                 455                 460                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
465                 470                 475                 480 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                485                 490                 495     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            500                 505                 510         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
        515                 520                 525             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    530                 535                 540                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
545                 550                 555                 560 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                565                 570                 575     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            580                 585                 590         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        595                 600                 605             


Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615     


<210>  155
<211>  611
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human ROR2-Fc (CHO)

<400>  155

Glu Val Glu Val Leu Asp Pro Asn Asp Pro Leu Gly Pro Leu Asp Gly 
1               5                   10                  15      


Gln Asp Gly Pro Ile Pro Thr Leu Lys Gly Tyr Phe Leu Asn Phe Leu 
            20                  25                  30          


Glu Pro Val Asn Asn Ile Thr Ile Val Gln Gly Gln Thr Ala Ile Leu 
        35                  40                  45              


His Cys Lys Val Ala Gly Asn Pro Pro Pro Asn Val Arg Trp Leu Lys 
    50                  55                  60                  


Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Ile Ile Ile Arg Lys 
65                  70                  75                  80  


Thr Glu Tyr Gly Ser Arg Leu Arg Ile Gln Asp Leu Asp Thr Thr Asp 
                85                  90                  95      


Thr Gly Tyr Tyr Gln Cys Val Ala Thr Asn Gly Met Lys Thr Ile Thr 
            100                 105                 110         


Ala Thr Gly Val Leu Phe Val Arg Leu Gly Pro Thr His Ser Pro Asn 
        115                 120                 125             


His Asn Phe Gln Asp Asp Tyr His Glu Asp Gly Phe Cys Gln Pro Tyr 
    130                 135                 140                 


Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Ile Tyr Val 
145                 150                 155                 160 


Asp Ser Leu Gln Met Gln Gly Glu Ile Glu Asn Arg Ile Thr Ala Ala 
                165                 170                 175     


Phe Thr Met Ile Gly Thr Ser Thr His Leu Ser Asp Gln Cys Ser Gln 
            180                 185                 190         


Phe Ala Ile Pro Ser Phe Cys His Phe Val Phe Pro Leu Cys Asp Ala 
        195                 200                 205             


Arg Ser Arg Thr Pro Lys Pro Arg Glu Leu Cys Arg Asp Glu Cys Glu 
    210                 215                 220                 


Val Leu Glu Ser Asp Leu Cys Arg Gln Glu Tyr Thr Ile Ala Arg Ser 
225                 230                 235                 240 


Asn Pro Leu Ile Leu Met Arg Leu Gln Leu Pro Lys Cys Glu Ala Leu 
                245                 250                 255     


Pro Met Pro Glu Ser Pro Asp Ala Ala Asn Cys Met Arg Ile Gly Ile 
            260                 265                 270         


Pro Ala Glu Arg Leu Gly Arg Tyr His Gln Cys Tyr Asn Gly Ser Gly 
        275                 280                 285             


Met Asp Tyr Arg Gly Thr Ala Ser Thr Thr Lys Ser Gly His Gln Cys 
    290                 295                 300                 


Gln Pro Trp Ala Leu Gln His Pro His Ser His His Leu Ser Ser Thr 
305                 310                 315                 320 


Asp Phe Pro Glu Leu Gly Gly Gly His Ala Tyr Cys Arg Asn Pro Gly 
                325                 330                 335     


Gly Gln Met Glu Gly Pro Trp Cys Phe Thr Gln Asn Lys Asn Val Arg 
            340                 345                 350         


Met Glu Leu Cys Asp Val Pro Ser Cys Ser Pro Arg Asp Ser Ser Lys 
        355                 360                 365             


Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
385                 390                 395                 400 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                405                 410                 415     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            420                 425                 430         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        435                 440                 445             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    450                 455                 460                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
465                 470                 475                 480 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                485                 490                 495     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            500                 505                 510         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        515                 520                 525             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    530                 535                 540                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
545                 550                 555                 560 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                565                 570                 575     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            580                 585                 590         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        595                 600                 605             


Pro Gly Lys 
    610     


<210>  156
<211>  616
<212>  PRT
<213>  artificial sequence

<220>
<223>  Mouse ROR1-Fc (CHO)

<400>  156

Gln Glu Thr Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser 
1               5                   10                  15      


Trp Asn Thr Ser Ser Glu Ile Asp Lys Gly Ser Tyr Leu Thr Leu Asp 
            20                  25                  30          


Glu Pro Met Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu 
        35                  40                  45              


His Cys Lys Val Ser Gly Asn Pro Pro Pro Ser Ile Arg Trp Phe Lys 
    50                  55                  60                  


Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Ile Ser Phe Arg Ala 
65                  70                  75                  80  


Thr Asn Tyr Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp 
                85                  90                  95      


Thr Gly Tyr Phe Gln Cys Val Ala Thr Asn Gly Lys Lys Val Val Ser 
            100                 105                 110         


Thr Thr Gly Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser 
        115                 120                 125             


Pro Gly Ser Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr 
    130                 135                 140                 


Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met 
145                 150                 155                 160 


Glu Ser Leu His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala 
                165                 170                 175     


Phe Thr Met Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln 
            180                 185                 190         


Phe Ala Ile Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu 
        195                 200                 205             


Thr Ser Ser Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu 
    210                 215                 220                 


Val Leu Glu Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser 
225                 230                 235                 240 


Asn Pro Met Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu 
                245                 250                 255     


Pro Gln Pro Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile 
            260                 265                 270         


Pro Met Ala Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr 
        275                 280                 285             


Gly Val Asp Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln 
    290                 295                 300                 


Cys Gln Pro Trp Asn Ser Gln Tyr Pro His Thr His Ser Phe Thr Ala 
305                 310                 315                 320 


Leu Arg Phe Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro 
                325                 330                 335     


Gly Asn Gln Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe 
            340                 345                 350         


Lys Ser Asp Leu Cys Asp Ile Pro Ala Cys Asp Ser Lys Asp Ser Lys 
        355                 360                 365             


Glu Lys Asn Lys Met Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
385                 390                 395                 400 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                405                 410                 415     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            420                 425                 430         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        435                 440                 445             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    450                 455                 460                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
465                 470                 475                 480 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                485                 490                 495     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            500                 505                 510         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
        515                 520                 525             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    530                 535                 540                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
545                 550                 555                 560 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                565                 570                 575     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            580                 585                 590         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        595                 600                 605             


Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615     


<210>  157
<211>  616
<212>  PRT
<213>  artificial sequence

<220>
<223>  Rat ROR1-Fc (CHO)

<400>  157

Gln Glu Thr Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser 
1               5                   10                  15      


Trp Asn Thr Ser Ser Glu Ile Asp Lys Asp Ser Tyr Leu Thr Leu Asp 
            20                  25                  30          


Glu Pro Met Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu 
        35                  40                  45              


His Cys Lys Val Ser Gly Asn Pro Pro Pro Asn Ile Arg Trp Phe Lys 
    50                  55                  60                  


Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Ile Ser Phe Arg Ala 
65                  70                  75                  80  


Thr Asn Tyr Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp 
                85                  90                  95      


Thr Gly Tyr Phe Gln Cys Val Ala Thr Ser Gly Lys Lys Val Val Ser 
            100                 105                 110         


Thr Thr Gly Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser 
        115                 120                 125             


Pro Gly Ser Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr 
    130                 135                 140                 


Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met 
145                 150                 155                 160 


Glu Ser Leu His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala 
                165                 170                 175     


Phe Thr Met Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln 
            180                 185                 190         


Phe Ala Ile Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu 
        195                 200                 205             


Thr Ser Ser Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu 
    210                 215                 220                 


Val Leu Glu Asn Val Leu Cys His Thr Glu Tyr Ile Phe Ala Arg Ser 
225                 230                 235                 240 


Asn Pro Met Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu 
                245                 250                 255     


Pro Gln Pro Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile 
            260                 265                 270         


Pro Met Ala Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr 
        275                 280                 285             


Gly Val Asp Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln 
    290                 295                 300                 


Cys Gln Pro Trp Asn Ser Gln Tyr Pro His Thr His Ser Phe Thr Ala 
305                 310                 315                 320 


Leu Arg Phe Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro 
                325                 330                 335     


Gly Asn Gln Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe 
            340                 345                 350         


Lys Ser Asp Leu Cys Asp Ile Pro Ala Cys Asp Ser Lys Asp Ser Lys 
        355                 360                 365             


Glu Lys Asn Lys Met Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
385                 390                 395                 400 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                405                 410                 415     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            420                 425                 430         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        435                 440                 445             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    450                 455                 460                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
465                 470                 475                 480 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                485                 490                 495     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            500                 505                 510         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
        515                 520                 525             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    530                 535                 540                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
545                 550                 555                 560 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                565                 570                 575     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            580                 585                 590         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        595                 600                 605             


Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615     


<210>  158
<211>  248
<212>  PRT
<213>  artificial sequence

<220>
<223>  Figure 7

<400>  158

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
1               5                   10                  15      


Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala 
            20                  25                  30          


Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile 
        35                  40                  45              


Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val 
    50                  55                  60                  


Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val 
65                  70                  75                  80  


Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp 
                85                  90                  95      


Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln 
            100                 105                 110         


Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp 
        115                 120                 125             


Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val 
    130                 135                 140                 


Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr 
145                 150                 155                 160 


Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu 
                165                 170                 175     


Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr 
            180                 185                 190         


Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr 
        195                 200                 205             


Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr 
    210                 215                 220                 


Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys 
225                 230                 235                 240 


Ser Phe Ser Arg Thr Pro Gly Lys 
                245             


<210>  159
<211>  247
<212>  PRT
<213>  artificial sequence

<220>
<223>  N-terminal VNAR hFc (linker-hFc sequence)

<400>  159

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
1               5                   10                  15      


Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            20                  25                  30          


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        35                  40                  45              


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    50                  55                  60                  


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
65                  70                  75                  80  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                85                  90                  95      


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            100                 105                 110         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        115                 120                 125             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    130                 135                 140                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
145                 150                 155                 160 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                165                 170                 175     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            180                 185                 190         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        195                 200                 205             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    210                 215                 220                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
225                 230                 235                 240 


Leu Ser Leu Ser Pro Gly Lys 
                245         


<210>  160
<211>  247
<212>  PRT
<213>  artificial sequence

<220>
<223>  Cysteine engineered variants for bioconjugation

<400>  160

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
1               5                   10                  15      


Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            20                  25                  30          


Glu Leu Leu Gly Gly Pro Cys Val Phe Leu Phe Pro Pro Lys Pro Lys 
        35                  40                  45              


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    50                  55                  60                  


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
65                  70                  75                  80  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                85                  90                  95      


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            100                 105                 110         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        115                 120                 125             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    130                 135                 140                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
145                 150                 155                 160 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                165                 170                 175     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            180                 185                 190         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        195                 200                 205             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    210                 215                 220                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
225                 230                 235                 240 


Leu Ser Leu Ser Pro Gly Lys 
                245         


<210>  161
<211>  247
<212>  PRT
<213>  artificial sequence

<220>
<223>  Cysteine engineered variants for bioconjugation

<400>  161

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
1               5                   10                  15      


Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            20                  25                  30          


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        35                  40                  45              


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    50                  55                  60                  


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
65                  70                  75                  80  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                85                  90                  95      


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            100                 105                 110         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        115                 120                 125             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    130                 135                 140                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
145                 150                 155                 160 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                165                 170                 175     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            180                 185                 190         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        195                 200                 205             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    210                 215                 220                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
225                 230                 235                 240 


Leu Cys Leu Ser Pro Gly Lys 
                245         


<210>  162
<211>  252
<212>  PRT
<213>  artificial sequence

<220>
<223>  C-terminal hFc VNAR (hFc-linker sequence)

<400>  162

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Cys Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250         


<210>  163
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Intein fusions: His tag

<400>  163

Gln Ala Cys Lys Ala His His His His His His Gly 
1               5                   10          


<210>  164
<211>  26
<212>  PRT
<213>  artificial sequence

<220>
<223>  Intein fusions: HisMyc tag

<400>  164

Gln Ala Cys Lys Ala His His His His His His Gly Ala Glu Phe Glu 
1               5                   10                  15      


Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly 
            20                  25      


<210>  165
<211>  356
<212>  PRT
<213>  artificial sequence

<220>
<223>  G3CP hFc(Y407T)

<400>  165

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Val Thr Gly Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Tyr Asn Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
        115                 120                 125             


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Lys 
        355     


<210>  166
<211>  356
<212>  PRT
<213>  artificial sequence

<220>
<223>  G3CPG4 hFc(Y407T)

<400>  166

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Met 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Tyr Pro Trp Gly Ala Gly Ala Pro Tyr Asn Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
        115                 120                 125             


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Lys 
        355     


<210>  167
<211>  354
<212>  PRT
<213>  artificial sequence

<220>
<223>  P3A1 hFc(T366Y)

<400>  167

Thr Arg Val Asp Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Thr Asp Thr Ser Tyr Gly Leu Tyr 
            20                  25                  30          


Ser Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Thr Asp Trp Glu Arg 
        35                  40                  45              


Met Ser Ile Gly Gly Arg Tyr Val Glu Ser Val Asn Lys Gly Ala Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln Trp 
                85                  90                  95      


Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp 
        115                 120                 125             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    130                 135                 140                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
145                 150                 155                 160 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                165                 170                 175     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            180                 185                 190         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        195                 200                 205             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    210                 215                 220                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
225                 230                 235                 240 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                245                 250                 255     


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
            260                 265                 270         


Tyr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        275                 280                 285             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    290                 295                 300                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
305                 310                 315                 320 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                325                 330                 335     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            340                 345                 350         


Gly Lys 
        


<210>  168
<211>  133
<212>  PRT
<213>  artificial sequence

<220>
<223>  NAC1.S

<400>  168

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Lys Tyr Gly Leu Tyr 
            20                  25                  30          


Ser Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Thr Asp Glu Glu 
        35                  40                  45              


Arg Ile Ile Ile Gly Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Ser 
    50                  55                  60                  


Lys Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala 
65                  70                  75                  80  


Thr Tyr Tyr Cys Arg Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln 
                85                  90                  95      


Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Gln Ala Ser Gly 
            100                 105                 110         


Ala His His His His His His Gly Ala Glu Phe Glu Gln Lys Leu Ile 
        115                 120                 125             


Ser Glu Glu Asp Leu 
    130             


<210>  169
<211>  133
<212>  PRT
<213>  artificial sequence

<220>
<223>  NAC6.S

<400>  169

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Arg Tyr Ala Leu Tyr 
            20                  25                  30          


Ser Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Thr Asp Glu Glu 
        35                  40                  45              


Arg Ile Ser Ile Gly Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Ser 
    50                  55                  60                  


Lys Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala 
65                  70                  75                  80  


Thr Tyr Tyr Cys Arg Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln 
                85                  90                  95      


Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Gln Ala Ser Gly 
            100                 105                 110         


Ala His His His His His His Gly Ala Glu Phe Glu Gln Lys Leu Ile 
        115                 120                 125             


Ser Glu Glu Asp Leu 
    130             


<210>  170
<211>  133
<212>  PRT
<213>  artificial sequence

<220>
<223>  NAE9.S

<400>  170

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Gly Thr Gly Tyr Gly Leu Tyr 
            20                  25                  30          


Ser Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Thr Asp Glu Glu 
        35                  40                  45              


Arg Met Ile Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Arg Thr 
    50                  55                  60                  


Lys Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala 
65                  70                  75                  80  


Thr Tyr Tyr Cys Arg Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln 
                85                  90                  95      


Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Gln Ala Ser Gly 
            100                 105                 110         


Ala His His His His His His Gly Ala Glu Phe Glu Gln Lys Leu Ile 
        115                 120                 125             


Ser Glu Glu Asp Leu 
    130             


<210>  171
<211>  133
<212>  PRT
<213>  artificial sequence

<220>
<223>  NAF3.S

<400>  171

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Lys Tyr Gly Leu Tyr 
            20                  25                  30          


Ala Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Pro Asp Glu Glu 
        35                  40                  45              


Arg Ile Ile Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Ser 
    50                  55                  60                  


Lys Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala 
65                  70                  75                  80  


Thr Tyr Tyr Cys Arg Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln 
                85                  90                  95      


Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Gln Ala Ser Gly 
            100                 105                 110         


Ala His His His His His His Gly Ala Glu Phe Glu Gln Lys Leu Ile 
        115                 120                 125             


Ser Glu Glu Asp Leu 
    130             


<210>  172
<211>  133
<212>  PRT
<213>  artificial sequence

<220>
<223>  NAF5.S

<400>  172

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Lys Tyr Ala Leu Phe 
            20                  25                  30          


Ser Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Thr Asn Glu Asp 
        35                  40                  45              


Arg Ile Ser Ile Gly Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr 
    50                  55                  60                  


Lys Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala 
65                  70                  75                  80  


Thr Tyr Tyr Cys Arg Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln 
                85                  90                  95      


Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Gln Ala Ser Gly 
            100                 105                 110         


Ala His His His His His His Gly Ala Glu Phe Glu Gln Lys Leu Ile 
        115                 120                 125             


Ser Glu Glu Asp Leu 
    130             


<210>  173
<211>  133
<212>  PRT
<213>  artificial sequence

<220>
<223>  AA5.S

<400>  173

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Gly Thr Gly Tyr Gly Leu Tyr 
            20                  25                  30          


Ser Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asp Glu Glu 
        35                  40                  45              


Arg Ile Ile Ile Gly Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Ser 
    50                  55                  60                  


Lys Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala 
65                  70                  75                  80  


Thr Tyr Tyr Cys Arg Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln 
                85                  90                  95      


Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Gln Ala Ser Gly 
            100                 105                 110         


Ala His His His His His His Gly Ala Glu Phe Glu Gln Lys Leu Ile 
        115                 120                 125             


Ser Glu Glu Asp Leu 
    130             


<210>  174
<211>  133
<212>  PRT
<213>  artificial sequence

<220>
<223>  AD10.S

<400>  174

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Gly Thr Lys Tyr Gly Leu Tyr 
            20                  25                  30          


Ser Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asp Lys Glu 
        35                  40                  45              


Ser Ile Ile Ile Gly Gly Arg Tyr Ser Glu Ser Val Asn Asn Gly Thr 
    50                  55                  60                  


Lys Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala 
65                  70                  75                  80  


Thr Tyr Tyr Cys Arg Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln 
                85                  90                  95      


Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Gln Ala Ser Gly 
            100                 105                 110         


Ala His His His His His His Gly Ala Glu Phe Glu Gln Lys Leu Ile 
        115                 120                 125             


Ser Glu Glu Asp Leu 
    130             


<210>  175
<211>  133
<212>  PRT
<213>  artificial sequence

<220>
<223>  AE3.S

<400>  175

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Gly Thr Arg Tyr Gly Leu Tyr 
            20                  25                  30          


Ser Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asp Glu Glu 
        35                  40                  45              


Arg Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr 
    50                  55                  60                  


Lys Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala 
65                  70                  75                  80  


Thr Tyr Tyr Cys Arg Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln 
                85                  90                  95      


Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Gln Ala Ser Gly 
            100                 105                 110         


Ala His His His His His His Gly Ala Glu Phe Glu Gln Lys Leu Ile 
        115                 120                 125             


Ser Glu Glu Asp Leu 
    130             


<210>  176
<211>  133
<212>  PRT
<213>  artificial sequence

<220>
<223>  AF4.S

<400>  176

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Arg Tyr Ala Leu Tyr 
            20                  25                  30          


Ala Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Thr Asp Glu Asp 
        35                  40                  45              


Arg Ile Ile Ile Gly Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Ser 
    50                  55                  60                  


Lys Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala 
65                  70                  75                  80  


Thr Tyr Tyr Cys Arg Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln 
                85                  90                  95      


Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Gln Ala Ser Gly 
            100                 105                 110         


Ala His His His His His His Gly Ala Glu Phe Glu Gln Lys Leu Ile 
        115                 120                 125             


Ser Glu Glu Asp Leu 
    130             


<210>  177
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  WobbeCys-G4S linker

<400>  177

Pro Gly Val Gln Pro Cys Pro Gly Gly Gly Gly Gly Ser 
1               5                   10              


<210>  178
<211>  356
<212>  PRT
<213>  artificial sequence

<220>
<223>  G3CP-hFc(S239C)

<400>  178

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Val Thr Gly Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Tyr Asn Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
        115                 120                 125             


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Cys Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Lys 
        355     


<210>  179
<211>  356
<212>  PRT
<213>  artificial sequence

<220>
<223>  G3CPG4-hFc(S239C)

<400>  179

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Met 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Tyr Pro Trp Gly Ala Gly Ala Pro Tyr Asn Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
        115                 120                 125             


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Cys Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Lys 
        355     


<210>  180
<211>  356
<212>  PRT
<213>  artificial sequence

<220>
<223>  1H8-hFc (S239C)

<400>  180

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Val Thr Gly Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Ser Ser Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
        115                 120                 125             


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Cys Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Lys 
        355     


<210>  181
<211>  356
<212>  PRT
<213>  artificial sequence

<220>
<223>  1H8 G4-hFc (S239C)

<400>  181

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Met 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Tyr Pro Trp Gly Ala Gly Ala Pro Ser Ser Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
        115                 120                 125             


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Cys Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Lys 
        355     


<210>  182
<211>  356
<212>  PRT
<213>  artificial sequence

<220>
<223>  1H8 V15-hFc (S239C)

<400>  182

Ala Ser Val Thr Gln Ser Pro Arg Ser Ala Ser Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Thr Cys Arg Val Thr Gly Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Ser Ser Leu Thr Val Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Ser Ser Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Gln Gly Thr Lys Leu Glu Val Lys Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
        115                 120                 125             


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Cys Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Lys 
        355     


<210>  183
<211>  356
<212>  PRT
<213>  artificial sequence

<220>
<223>  1H8-hFc

<400>  183

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Val Thr Gly Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Ser Ser Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
        115                 120                 125             


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Lys 
        355     


<210>  184
<211>  356
<212>  PRT
<213>  artificial sequence

<220>
<223>  1H8 G4-hFc

<400>  184

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Met 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Tyr Pro Trp Gly Ala Gly Ala Pro Ser Ser Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
        115                 120                 125             


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Lys 
        355     


<210>  185
<211>  356
<212>  PRT
<213>  artificial sequence

<220>
<223>  1H8 V15-hFc

<400>  185

Ala Ser Val Thr Gln Ser Pro Arg Ser Ala Ser Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Thr Cys Arg Val Thr Gly Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Ser Ser Leu Thr Val Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Ser Ser Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Gln Gly Thr Lys Leu Glu Val Lys Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
        115                 120                 125             


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Lys 
        355     


<210>  186
<211>  356
<212>  PRT
<213>  artificial sequence

<220>
<223>  G3CP-hFc

<400>  186

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Val Thr Gly Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Tyr Asn Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
        115                 120                 125             


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Lys 
        355     


<210>  187
<211>  356
<212>  PRT
<213>  artificial sequence

<220>
<223>  G3CPG4-hFc

<400>  187

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Met 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Tyr Pro Trp Gly Ala Gly Ala Pro Tyr Asn Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
        115                 120                 125             


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Lys 
        355     


<210>  188
<211>  356
<212>  PRT
<213>  artificial sequence

<220>
<223>  G3CP hFc(T366Y)

<400>  188

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Val Thr Gly Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Tyr Asn Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
        115                 120                 125             


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Tyr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Lys 
        355     


<210>  189
<211>  355
<212>  PRT
<213>  artificial sequence

<220>
<223>  G3CPG4 hFc (T366Y)

<400>  189

Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
1               5                   10                  15      


Val Thr Ile Thr Cys Val Leu Thr Asp Ala Asn Tyr Gly Leu Ala Ala 
            20                  25                  30          


Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys Glu Arg Ile 
        35                  40                  45              


Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Met Ser 
    50                  55                  60                  


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr Tyr 
65                  70                  75                  80  


Tyr Cys Arg Ala Tyr Pro Trp Gly Ala Gly Ala Pro Tyr Asn Val Gln 
                85                  90                  95      


Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser 
        115                 120                 125             


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    130                 135                 140                 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
145                 150                 155                 160 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                165                 170                 175     


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            180                 185                 190         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        195                 200                 205             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    210                 215                 220                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
225                 230                 235                 240 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                245                 250                 255     


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
            260                 265                 270         


Leu Tyr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        275                 280                 285             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    290                 295                 300                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
305                 310                 315                 320 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                325                 330                 335     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            340                 345                 350         


Pro Gly Lys 
        355 


<210>  190
<211>  354
<212>  PRT
<213>  artificial sequence

<220>
<223>  P3A1 hFc (Y407T)

<400>  190

Thr Arg Val Asp Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Thr Asp Thr Ser Tyr Gly Leu Tyr 
            20                  25                  30          


Ser Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Thr Asp Trp Glu Arg 
        35                  40                  45              


Met Ser Ile Gly Gly Arg Tyr Val Glu Ser Val Asn Lys Gly Ala Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln Trp 
                85                  90                  95      


Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp 
        115                 120                 125             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    130                 135                 140                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
145                 150                 155                 160 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                165                 170                 175     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            180                 185                 190         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        195                 200                 205             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    210                 215                 220                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
225                 230                 235                 240 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                245                 250                 255     


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
            260                 265                 270         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        275                 280                 285             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    290                 295                 300                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr Val Asp 
305                 310                 315                 320 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                325                 330                 335     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            340                 345                 350         


Gly Lys 
        


<210>  191
<211>  356
<212>  PRT
<213>  artificial sequence

<220>
<223>  G3CP hFc(S239C+T366Y)

<400>  191

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Val Thr Gly Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Tyr Asn Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
        115                 120                 125             


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Cys Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Tyr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Lys 
        355     


<210>  192
<211>  356
<212>  PRT
<213>  artificial sequence

<220>
<223>  G3CPG4 hFc (S239C+T366Y)

<400>  192

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Met 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Tyr Pro Trp Gly Ala Gly Ala Pro Tyr Asn Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
        115                 120                 125             


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Cys Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Tyr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Lys 
        355     


<210>  193
<211>  354
<212>  PRT
<213>  artificial sequence

<220>
<223>  P3A1 hFc (S239C+Y407T)

<400>  193

Thr Arg Val Asp Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Thr Asp Thr Ser Tyr Gly Leu Tyr 
            20                  25                  30          


Ser Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Thr Asp Trp Glu Arg 
        35                  40                  45              


Met Ser Ile Gly Gly Arg Tyr Val Glu Ser Val Asn Lys Gly Ala Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln Trp 
                85                  90                  95      


Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp 
        115                 120                 125             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    130                 135                 140                 


Pro Cys Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
145                 150                 155                 160 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                165                 170                 175     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            180                 185                 190         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        195                 200                 205             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    210                 215                 220                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
225                 230                 235                 240 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                245                 250                 255     


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
            260                 265                 270         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        275                 280                 285             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    290                 295                 300                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr Val Asp 
305                 310                 315                 320 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                325                 330                 335     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            340                 345                 350         


Gly Lys 
        


<210>  194
<211>  356
<212>  PRT
<213>  artificial sequence

<220>
<223>  1H8 hFc (S239C+Y407T)

<400>  194

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Val Thr Gly Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Ser Ser Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
        115                 120                 125             


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Cys Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Lys 
        355     


<210>  195
<211>  356
<212>  PRT
<213>  artificial sequence

<220>
<223>  1H8 G4 hFc (S239C+Y407T)

<400>  195

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Met 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Tyr Pro Trp Gly Ala Gly Ala Pro Ser Ser Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
        115                 120                 125             


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Cys Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Lys 
        355     


<210>  196
<211>  356
<212>  PRT
<213>  artificial sequence

<220>
<223>  1H8 v15 hFc (S239C+Y407T)

<400>  196

Ala Ser Val Thr Gln Ser Pro Arg Ser Ala Ser Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Thr Cys Arg Val Thr Gly Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Ser Ser Leu Thr Val Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Ser Ser Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Gln Gly Thr Lys Leu Glu Val Lys Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
        115                 120                 125             


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Cys Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Lys 
        355     


<210>  197
<211>  356
<212>  PRT
<213>  artificial sequence

<220>
<223>  1H8 hFc (S239C+T366Y)

<400>  197

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Val Thr Gly Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Ser Ser Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
        115                 120                 125             


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Cys Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Tyr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Lys 
        355     


<210>  198
<211>  356
<212>  PRT
<213>  artificial sequence

<220>
<223>  1H8 G4 hFc (S239C+T366Y)

<400>  198

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Met 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Tyr Pro Trp Gly Ala Gly Ala Pro Ser Ser Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
        115                 120                 125             


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Cys Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Tyr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Lys 
        355     


<210>  199
<211>  356
<212>  PRT
<213>  artificial sequence

<220>
<223>  1H8 v15 hFc (S239C+T366Y)

<400>  199

Ala Ser Val Thr Gln Ser Pro Arg Ser Ala Ser Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Thr Cys Arg Val Thr Gly Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Ser Ser Leu Thr Val Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Ser Ser Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Gln Gly Thr Lys Leu Glu Val Lys Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
        115                 120                 125             


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Cys Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Tyr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Lys 
        355     


<210>  200
<211>  356
<212>  PRT
<213>  artificial sequence

<220>
<223>  1H8 hFc (Y407T)

<400>  200

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Val Thr Gly Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Ser Ser Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
        115                 120                 125             


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Lys 
        355     


<210>  201
<211>  356
<212>  PRT
<213>  artificial sequence

<220>
<223>  1H8 G4 hFc (Y407T)

<400>  201

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Met 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Tyr Pro Trp Gly Ala Gly Ala Pro Ser Ser Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
        115                 120                 125             


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Lys 
        355     


<210>  202
<211>  356
<212>  PRT
<213>  artificial sequence

<220>
<223>  1H8 v15 hFc (Y407T)

<400>  202

Ala Ser Val Thr Gln Ser Pro Arg Ser Ala Ser Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Thr Cys Arg Val Thr Gly Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Ser Ser Leu Thr Val Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Ser Ser Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Gln Gly Thr Lys Leu Glu Val Lys Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
        115                 120                 125             


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Lys 
        355     


<210>  203
<211>  356
<212>  PRT
<213>  artificial sequence

<220>
<223>  1H8 hFc (T366Y)

<400>  203

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Val Thr Gly Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Ser Ser Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
        115                 120                 125             


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Tyr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Lys 
        355     


<210>  204
<211>  356
<212>  PRT
<213>  Artificial sequence

<220>
<223>  1H8 G4 hFc (T366Y)

<400>  204

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Met 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Tyr Pro Trp Gly Ala Gly Ala Pro Ser Ser Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
        115                 120                 125             


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Tyr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Lys 
        355     


<210>  205
<211>  356
<212>  PRT
<213>  1H8 v15 hFc (T366Y)

<400>  205

Ala Ser Val Thr Gln Ser Pro Arg Ser Ala Ser Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Thr Cys Arg Val Thr Gly Ala Asn Tyr Gly Leu Ala 
            20                  25                  30          


Ala Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Gln Glu Arg 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Arg Thr Met 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Ser Ser Leu Thr Val Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Tyr Pro Trp Gly Ala Gly Ala Pro Ser Ser Val 
                85                  90                  95      


Gln Trp Tyr Asp Gly Gln Gly Thr Lys Leu Glu Val Lys Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
        115                 120                 125             


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Tyr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Lys 
        355     


