                         SEQUENCE LISTING

<110>  AC Immune SA
      
<120>  ANTIBODY DELIVERY

<130>  P218778WO00

<150>  EP 20215823.4
<151>  2020-12-18

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  588
<212>  DNA
<213>  Encephalomyocarditis virus

<400>  1
gcccctctcc ctcccccccc cctaacgtta ctggccgaag ccgcttggaa taaggccggt       60

gtgcgtttgt ctatatgtta ttttccacca tattgccgtc ttttggcaat gtgagggccc      120

ggaaacctgg ccctgtcttc ttgacgagca ttcctagggg tctttcccct ctcgccaaag      180

gaatgcaagg tctgttgaat gtcgtgaagg aagcagttcc tctggaagct tcttgaagac      240

aaacaacgtc tgtagcgacc ctttgcaggc agcggaaccc cccacctggc gacaggtgcc      300

tctgcggcca aaagccacgt gtataagata cacctgcaaa ggcggcacaa ccccagtgcc      360

acgttgtgag ttggatagtt gtggaaagag tcaaatggct ctcctcaagc gtattcaaca      420

aggggctgaa ggatgcccag aaggtacccc attgtatggg atctgatctg gggcctcggt      480

gcacatgctt tacatgtgtt tagtcgaggt taaaaaaacg tctaggcccc ccgaaccacg      540

gggacgtggt tttcctttga aaaacacgat gataatatgg ccacaacc                   588


<210>  2
<211>  4528
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse MAB2, promoter-LC-IRES-HC-WPRE

<400>  2
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc ttctagacaa ctttgtatag aaaagttgta gttattaata      180

gtaatcaatt acggggtcat tagttcatag cccatatatg gagttccgcg ttacataact      240

tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga cgtcaataat      300

gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggagta      360

tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa gtacgccccc      420

tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttatg      480

ggactttcct acttggcagt acatctacgt attagtcatc gctattacca tggtgatgcg      540

gttttggcag tacatcaatg ggcgtggata gcggtttgac tcacggggat ttccaagtct      600

ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg actttccaaa      660

atgtcgtaac aactccgccc cattgacgca aatgggcggt aggcgtgtac ggtgggaggt      720

ctatataagc agagctggtt tagtgaaccg tcagatccaa gtttgtacaa aaaagcaggc      780

tgccaccatg gagacagata cactgctgct gtgggtgctg ctcctctggg tgccaggatc      840

tacaggcgac atcgtgatga cccagagcca caagttcatg agcaccagcg tgggcgacag      900

agtgtccatc acatgcaagg ccagccagga cgtgaacaca gccgtggctt ggtatcagca      960

gaagcccggc cattctccta agctgctgat ctacagcgcc agcttcagat acaccggcgt     1020

gcccgataga ttcaccggca acagaagcgg caccgacttc accttcacca tcagctctgt     1080

gcaggccgag gatctggccg tgtactactg tcagcagcac tacaccacac ctccaacctt     1140

cggcggaggc accaaggtgg aaatcaagag agctgacgcc gctcctaccg tgtctatctt     1200

cccacctagc agcgagcagc tgacatctgg cggagcctct gtcgtgtgct tcctgaacaa     1260

cttctacccc aaggacatca acgtgaagtg gaagatcgac ggcagcgaga gacagaacgg     1320

cgtgctgaac tcttggaccg accaggacag caaggactcc acctacagca tgagcagcac     1380

cctgacactg accaaggacg agtacgagag acacaacagc tacacatgcg aggctaccca     1440

caagaccagc acaagcccca tcgtgaagtc cttcaacaga aacgagtgct gaacccagct     1500

ttcttgtaca aagtgggccc ctctccctcc ccccccccta acgttactgg ccgaagccgc     1560

ttggaataag gccggtgtgc gtttgtctat atgttatttt ccaccatatt gccgtctttt     1620

ggcaatgtga gggcccggaa acctggccct gtcttcttga cgagcattcc taggggtctt     1680

tcccctctcg ccaaaggaat gcaaggtctg ttgaatgtcg tgaaggaagc agttcctctg     1740

gaagcttctt gaagacaaac aacgtctgta gcgacccttt gcaggcagcg gaacccccca     1800

cctggcgaca ggtgcctctg cggccaaaag ccacgtgtat aagatacacc tgcaaaggcg     1860

gcacaacccc agtgccacgt tgtgagttgg atagttgtgg aaagagtcaa atggctctcc     1920

tcaagcgtat tcaacaaggg gctgaaggat gcccagaagg taccccattg tatgggatct     1980

gatctggggc ctcggtgcac atgctttaca tgtgtttagt cgaggttaaa aaaacgtcta     2040

ggccccccga accacgggga cgtggttttc ctttgaaaaa cacgatgata atatggccac     2100

aaccatggag acagatacac tgctgctgtg ggtgctgctc ctctgggtgc caggatctac     2160

aggccaggtt cagctgcagc agtctggacc tgagctggtt aagcctggcg cctctctgaa     2220

gctgagctgt accgcttccg gcttcaacat caaggacacc tacatccact gggtcaagca     2280

gaggcctgag cagggactcg agtggatcgg cagaatctac cccaccaacg gctacaccag     2340

atacgacccc aagttccagg acaaggccac catcacagcc gacaccagca gcaacacagc     2400

ctatctccag gtgtccaggc tgaccagcga ggacacagcc gtgtactact gctctagatg     2460

gggaggcgac ggcttctacg ccatggatta ttggggacag ggcgccagcg tgacagtgtc     2520

tagtgccaag acaacagccc ctagcgtgta ccctctggct cctgtgtgtg gcgacacaac     2580

aggcagctct gtgacactgg gctgtctggt caagggctac ttccccgaac cagtgacact     2640

gacctggaac agcggctctc tgtctagcgg cgtgcacaca tttccagccg tgctgcagag     2700

cgacctgtac acactgtcct ctagcgtgac cgtgaccagc tctacatggc ccagccagag     2760

catcacctgt aacgtggccc atcctgccag cagcaccaag gtggacaaga agatcgagcc     2820

tagaggccct accatcaagc cctgtcctcc atgcaagtgc cccgctccta atctgctcgg     2880

aggcccaagc gtgttcatct tcccacctaa gatcaaggac gtgctgatga tctctctgag     2940

ccccatcgtg acctgcgtgg tggtggatgt gtctgaggac gaccctgacg tgcagatcag     3000

ttggttcgtg aacaacgtgg aagtgcacac agcccagaca cagacccaca gagaggacta     3060

caacagcacc ctgagagtgg tgtctgccct gcctatccag caccaggatt ggatgagcgg     3120

caaagaattc aagtgcaaag tgaacaacaa ggacctgcct gctcctatcg agagaaccat     3180

cagcaagccc aagggctctg tcagggctcc tcaggtgtac gttctgccac ctcctgagga     3240

agagatgacc aagaaacaag tgaccctcac ctgtatggtc accgacttca tgcccgagga     3300

catctacgtg gaatggacca acaacggcaa gaccgagctg aactacaaga acaccgagcc     3360

tgtgctggac agcgacggca gctacttcat gtacagcaag ctgcgcgtcg agaagaagaa     3420

ctgggtcgag agaaacagct acagctgctc cgtggtgcac gagggactgc acaaccacca     3480

caccaccaag agcttcagca gaacccctgg caagtgacaa ctttattata catagttgga     3540

attccgataa tcaacctctg gattacaaaa tttgtgaaag attgactggt attcttaact     3600

atgttgctcc ttttacgcta tgtggatacg ctgctttaat gcctttgtat catgctattg     3660

cttcccgtat ggctttcatt ttctcctcct tgtataaatc ctggttgctg tctctttatg     3720

aggagttgtg gcccgttgtc aggcaacgtg gcgtggtgtg cactgtgttt gctgacgcaa     3780

cccccactgg ttggggcatt gccaccacct gtcagctcct ttccgggact ttcgctttcc     3840

ccctccctat tgccacggcg gaactcatcg ccgcctgcct tgcccgctgc tggacagggg     3900

ctcggctgtt gggcactgac aattccgtgg tgttgtcggg gaagctgacg tcctttccat     3960

ggctgctcgc ctgtgttgcc acctggattc tgcgcgggac gtccttctgc tacgtccctt     4020

cggccctcaa tccagcggac cttccttccc gcggcctgct gccggctctg cggcctcttc     4080

cgcgtcttcg ccttcgccct cagacgagtc ggatctccct ttgggccgcc tccccgcatc     4140

gggaattcct agagctcgct gatcagcctc gactgtgcct tctagttgcc agccatctgt     4200

tgtttgcccc tcccccgtgc cttccttgac cctggaaggt gccactccca ctgtcctttc     4260

ctaataaaat gaggaaattg catcgcattg tctgagtagg tgtcattcta ttctgggggg     4320

tggggtgggg caggacagca agggggagga ttgggaagag aatagcaggc atgctgggga     4380

gggccgcagg aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc     4440

actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg     4500

agcgagcgag cgcgcagctg cctgcagg                                        4528


<210>  3
<211>  4153
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse MAB2 - 2 promoters IgG, consisting of promoter 1 
       (CMV)-LC-polyA-promoter 2 (CMV)-HC-WPRE-poly A

<400>  3
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc ttctagacaa ctttgtatag aaaagttgta gttattaata      180

gtaatcaatt acggggtcat tagttcatag cccatatatg gagttccgcg ttacataact      240

tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga cgtcaataat      300

gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggagta      360

tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa gtacgccccc      420

tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttatg      480

ggactttcct acttggcagt acatctacgt attagtcatc gctattacca tggtgatgcg      540

gttttggcag tacatcaatg ggcgtggata gcggtttgac tcacggggat ttccaagtct      600

ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg actttccaaa      660

atgtcgtaac aactccgccc cattgacgca aatgggcggt aggcgtgtac ggtgggaggt      720

ctatataagc agagctggtt tagtgaaccg tcagatccaa gtttgtacaa aaaagcaggc      780

tgccaccatg gagacagata cactgctgct gtgggtgctg ctcctctggg tgccaggatc      840

tacaggcgac atcgtgatga cccagagcca caagttcatg agcaccagcg tgggcgacag      900

agtgtccatc acatgcaagg ccagccagga cgtgaacaca gccgtggctt ggtatcagca      960

gaagcccggc cattctccta agctgctgat ctacagcgcc agcttcagat acaccggcgt     1020

gcccgataga ttcaccggca acagaagcgg caccgacttc accttcacca tcagctctgt     1080

gcaggccgag gatctggccg tgtactactg tcagcagcac tacaccacac ctccaacctt     1140

cggcggaggc accaaggtgg aaatcaagag agctgacgcc gctcctaccg tgtctatctt     1200

cccacctagc agcgagcagc tgacatctgg cggagcctct gtcgtgtgct tcctgaacaa     1260

cttctacccc aaggacatca acgtgaagtg gaagatcgac ggcagcgaga gacagaacgg     1320

cgtgctgaac tcttggaccg accaggacag caaggactcc acctacagca tgagcagcac     1380

cctgacactg accaaggacg agtacgagag acacaacagc tacacatgcg aggctaccca     1440

caagaccagc acaagcccca tcgtgaagtc cttcaacaga aacgagtgct gacagacatg     1500

ataagataca ttgatgagtt tggacaaacc acaactagaa tgcagtgaaa aaaatgcttt     1560

atttgtgaaa tttgtgatgc tattgcttta tttgtaacca ttataagctg caataaacaa     1620

gttaacaaca acaattgcat tcattttatg tttcaggttc agggggaggt gtgggaggtt     1680

ttttaaagca agtaaaacct ctacaaatgt ggtatagtta ttaatagtaa tcaattacgg     1740

ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc     1800

cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca     1860

tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg     1920

cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt gacgtcaatg     1980

acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac tttcctactt     2040

ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt tggcagtaca     2100

tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac cccattgacg     2160

tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt cgtaacaact     2220

ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag     2280

ctggtttagt gaaccgtcag atcacccagc tttcttgtac aaagtgggcc accatggaga     2340

cagatacact gctgctgtgg gtgctgctcc tctgggtgcc aggatctaca ggccaggttc     2400

agctgcagca gtctggacct gagctggtta agcctggcgc ctctctgaag ctgagctgta     2460

ccgcttccgg cttcaacatc aaggacacct acatccactg ggtcaagcag aggcctgagc     2520

agggactcga gtggatcggc agaatctacc ccaccaacgg ctacaccaga tacgacccca     2580

agttccagga caaggccacc atcacagccg acaccagcag caacacagcc tatctccagg     2640

tgtccaggct gaccagcgag gacacagccg tgtactactg ctctagatgg ggaggcgacg     2700

gcttctacgc catggattat tggggacagg gcgccagcgt gacagtgtct agtgccaaga     2760

caacagcccc tagcgtgtac cctctggctc ctgtgtgtgg cgacacaaca ggcagctctg     2820

tgacactggg ctgtctggtc aagggctact tccccgaacc agtgacactg acctggaaca     2880

gcggctctct gtctagcggc gtgcacacat ttccagccgt gctgcagagc gacctgtaca     2940

cactgtcctc tagcgtgacc gtgaccagct ctacatggcc cagccagagc atcacctgta     3000

acgtggccca tcctgccagc agcaccaagg tggacaagaa gatcgagcct agaggcccta     3060

ccatcaagcc ctgtcctcca tgcaagtgcc ccgctcctaa tctgctcgga ggcccaagcg     3120

tgttcatctt cccacctaag atcaaggacg tgctgatgat ctctctgagc cccatcgtga     3180

cctgcgtggt ggtggatgtg tctgaggacg accctgacgt gcagatcagt tggttcgtga     3240

acaacgtgga agtgcacaca gcccagacac agacccacag agaggactac aacagcaccc     3300

tgagagtggt gtctgccctg cctatccagc accaggattg gatgagcggc aaagaattca     3360

agtgcaaagt gaacaacaag gacctgcctg ctcctatcga gagaaccatc agcaagccca     3420

agggctctgt cagggctcct caggtgtacg ttctgccacc tcctgaggaa gagatgacca     3480

agaaacaagt gaccctcacc tgtatggtca ccgacttcat gcccgaggac atctacgtgg     3540

aatggaccaa caacggcaag accgagctga actacaagaa caccgagcct gtgctggaca     3600

gcgacggcag ctacttcatg tacagcaagc tgcgcgtcga gaagaagaac tgggtcgaga     3660

gaaacagcta cagctgctcc gtggtgcacg agggactgca caaccaccac accaccaaga     3720

gcttcagcag aacccctggc aagtgacaac tttattatac atagttggaa ttcctagagc     3780

tcgctgatca gcctcgactg tgccttctag ttgccagcca tctgttgttt gcccctcccc     3840

cgtgccttcc ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga     3900

aattgcatcg cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga     3960

cagcaagggg gaggattggg aagagaatag caggcatgct ggggagggcc gcaggaaccc     4020

ctagtgatgg agttggccac tccctctctg cgcgctcgct cgctcactga ggccgggcga     4080

ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc     4140

agctgcctgc agg                                                        4153


<210>  4
<211>  4483
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse MAB1, promoter-LC-IRES shorter-HC-WPRE

<400>  4
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc ttctagacaa ctttgtatag aaaagttgta gttattaata      180

gtaatcaatt acggggtcat tagttcatag cccatatatg gagttccgcg ttacataact      240

tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga cgtcaataat      300

gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggagta      360

tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa gtacgccccc      420

tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttatg      480

ggactttcct acttggcagt acatctacgt attagtcatc gctattacca tggtgatgcg      540

gttttggcag tacatcaatg ggcgtggata gcggtttgac tcacggggat ttccaagtct      600

ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg actttccaaa      660

atgtcgtaac aactccgccc cattgacgca aatgggcggt aggcgtgtac ggtgggaggt      720

ctatataagc agagctggtt tagtgaaccg tcagatccaa gtttgtacaa aaaagcaggc      780

tgccaccatg gagacagata cactgctgct gtgggtgctg ctcctctggg tgccaggatc      840

tacaggcgac gtggtcatga cacagacccc tctgacactg agcgtgacca tcggacagcc      900

tgccagcatc agctgcaaga gcagtcagag cctgctgcac agcgacggca agacctacct      960

gaactggctg ctgcaaagac ccggccagtc tcctaagagg ctgatctacc tggtgtccaa     1020

gctggacagc agaatccccg acagattcac aggcagcggc tctggcacag acttcaccct     1080

gaagatcagc agagtggaag ccgaggacct gggcgtgtac tactgttggc agggcacaca     1140

cttccctcac acattcggcg ctggcacaaa gctggaactg aagagagctg acgccgctcc     1200

taccgtgtct atcttcccac ctagcagcga gcagctgaca tctggcggag cctctgtcgt     1260

gtgcttcctg aacaacttct accccaagga catcaacgtg aagtggaaga tcgacggcag     1320

cgagagacag aacggcgtgc tgaactcttg gaccgaccag gacagcaagg actccaccta     1380

cagcatgagc agcaccctga cactgaccaa ggacgagtac gagagacaca acagctacac     1440

atgcgaggct acccacaaga ccagcacaag ccccatcgtg aagtccttca acagaaacga     1500

gtgctgagcc cctctccctc ccccccccct aacgttactg gccgaagccg cttggaataa     1560

ggccggtgtg cgtttgtcta tatgttattt tccaccatat tgccgtcttt tggcaatgtg     1620

agggcccgga aacctggccc tgtcttcttg acgagcattc ctaggggtct ttcccctctc     1680

gccaaaggaa tgcaaggtct gttgaatgtc gtgaaggaag cagttcctct ggaagcttct     1740

tgaagacaaa caacgtctgt agcgaccctt tgcaggcagc ggaacccccc acctggcgac     1800

aggtgcctct gcggccaaaa gccacgtgta taagatacac ctgcaaaggc ggcacaaccc     1860

cagtgccacg ttgtgagttg gatagttgtg gaaagagtca aatggctctc ctcaagcgta     1920

ttcaacaagg ggctgaagga tgcccagaag gtaccccatt gtatgggatc tgatctgggg     1980

cctcggtgca catgctttac atgtgtttag tcgaggttaa aaaaacgtct aggccccccg     2040

aaccacgggg acgtggtttt cctttgaaaa acacgatgat aatatggaga cagatacact     2100

gctgctgtgg gtgctgctcc tctgggtgcc aggatctaca ggcgaggttc agctgcagca     2160

gtctggacct gagctggtta agcctggcgc ctccgtgaag atcagctgca agacaagcgg     2220

cttcaccttc accgagtaca gcatgcactg ggtcaagcag agccacggca agagcctgga     2280

atggatcggc ggcatcaacc ctaacaacgg cggcaccagc tacaaccaga agttcaaggg     2340

caaagccaca ctgaccgtgg acaagagcag cagcaccgcc tacatggaac tgagaagcct     2400

gaccagcgag gacagcgccg tgtactactg tgccagagag tcttggggcc agggcacaac     2460

cctgacagtc tcttctgcca agacaacagc ccctagcgtg taccctctgg ctcctgtgtg     2520

tggcgacaca acaggcagct ctgtgacact gggctgtctg gtcaagggct acttccccga     2580

accagtgaca ctgacctgga acagcggctc tctgtctagc ggcgtgcaca catttccagc     2640

cgtgctgcag agcgacctgt acacactgtc ctctagcgtg accgtgacca gctctacatg     2700

gcccagccag agcatcacct gtaacgtggc ccatcctgcc agcagcacca aggtggacaa     2760

gaagatcgag cctagaggcc ctaccatcaa gccctgtcct ccatgcaagt gccccgctcc     2820

taatctgctc ggaggcccaa gcgtgttcat cttcccacct aagatcaagg acgtgctgat     2880

gatctctctg agccccatcg tgacctgcgt ggtggtggat gtgtctgagg acgaccctga     2940

cgtgcagatc agttggttcg tgaacaacgt ggaagtgcac acagcccaga cacagaccca     3000

cagagaggac tacaacagca ccctgagagt ggtgtctgcc ctgcctatcc agcaccagga     3060

ttggatgagc ggcaaagaat tcaagtgcaa agtgaacaac aaggacctgc ctgctcctat     3120

cgagagaacc atcagcaagc ccaagggctc tgtcagggct cctcaggtgt acgttctgcc     3180

acctcctgag gaagagatga ccaagaaaca agtgaccctc acctgtatgg tcaccgactt     3240

catgcccgag gacatctacg tggaatggac caacaacggc aagaccgagc tgaactacaa     3300

gaacaccgag cctgtgctgg acagcgacgg cagctacttc atgtacagca agctgcgcgt     3360

cgagaagaag aactgggtcg agagaaacag ctacagctgc tccgtggtgc acgagggact     3420

gcacaaccac cacaccacca agagcttcag cagaacccct ggcaagtgaa cccagctttc     3480

ttgtacaaag tgggaattcc gataatcaac ctctggatta caaaatttgt gaaagattga     3540

ctggtattct taactatgtt gctcctttta cgctatgtgg atacgctgct ttaatgcctt     3600

tgtatcatgc tattgcttcc cgtatggctt tcattttctc ctccttgtat aaatcctggt     3660

tgctgtctct ttatgaggag ttgtggcccg ttgtcaggca acgtggcgtg gtgtgcactg     3720

tgtttgctga cgcaaccccc actggttggg gcattgccac cacctgtcag ctcctttccg     3780

ggactttcgc tttccccctc cctattgcca cggcggaact catcgccgcc tgccttgccc     3840

gctgctggac aggggctcgg ctgttgggca ctgacaattc cgtggtgttg tcggggaagc     3900

tgacgtcctt tccatggctg ctcgcctgtg ttgccacctg gattctgcgc gggacgtcct     3960

tctgctacgt cccttcggcc ctcaatccag cggaccttcc ttcccgcggc ctgctgccgg     4020

ctctgcggcc tcttccgcgt cttcgccttc gccctcagac gagtcggatc tccctttggg     4080

ccgcctcccc gcatcgggaa ttcctagagc tcgctgatca gcctcgactg tgccttctag     4140

ttgccagcca tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac     4200

tcccactgtc ctttcctaat aaaatgagga aattgcatcg cattgtctga gtaggtgtca     4260

ttctattctg gggggtgggg tggggcagga cagcaagggg gaggattggg aagagaatag     4320

caggcatgct ggggagggcc gcaggaaccc ctagtgatgg agttggccac tccctctctg     4380

cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc     4440

cgggcggcct cagtgagcga gcgagcgcgc agctgcctgc agg                       4483


<210>  5
<211>  4516
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MAB1 promoter-LC-IRES-HC-WPRE-PolyA

<400>  5
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc ttctagacaa ctttgtatag aaaagttgta gttattaata      180

gtaatcaatt acggggtcat tagttcatag cccatatatg gagttccgcg ttacataact      240

tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga cgtcaataat      300

gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggagta      360

tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa gtacgccccc      420

tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttatg      480

ggactttcct acttggcagt acatctacgt attagtcatc gctattacca tggtgatgcg      540

gttttggcag tacatcaatg ggcgtggata gcggtttgac tcacggggat ttccaagtct      600

ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg actttccaaa      660

atgtcgtaac aactccgccc cattgacgca aatgggcggt aggcgtgtac ggtgggaggt      720

ctatataagc agagctggtt tagtgaaccg tcagatccaa gtttgtacaa aaaagcaggc      780

tgccaccatg gagacagata cactgctgct gtgggtgctg ctcctctggg tgccaggatc      840

tacaggcgac gtggtcatga cacagacccc tctgacactg tccgtgacca tcggacagcc      900

tgcctccatc tcctgcaagt cctctcagtc cctgctgcac tctgacggca agacctacct      960

gaactggctg ctgcagaggc ctggccagag tcctaagaga ctgatctacc tggtgtccaa     1020

gctggactct cggatccctg acagattcac cggctctggc tctggcaccg acttcaccct     1080

gaagatctcc agagtggaag ccgaggacct gggcgtgtac tactgttggc agggcaccca     1140

ctttccacac acctttggcg ctggcacaaa gctggaactg aagcggacag tggccgctcc     1200

ttccgtgttc atcttcccac cttccgacga gcagctgaag tccggcacag cttctgtcgt     1260

gtgcctgctg aacaacttct accctcggga agccaaggtg cagtggaagg tggacaatgc     1320

cctgcagtcc ggcaactccc aagagtctgt gaccgagcag gactccaagg acagcaccta     1380

cagcctgtcc tccacactga ccctgtccaa ggccgactac gagaagcaca aggtgtacgc     1440

ctgcgaagtg acccatcagg gcctgtctag ccctgtgacc aagtctttca accggggcga     1500

gtgttgaacc cagctttctt gtacaaagtg ggcccctctc cctccccccc ccctaacgtt     1560

actggccgaa gccgcttgga ataaggccgg tgtgcgtttg tctatatgtt attttccacc     1620

atattgccgt cttttggcaa tgtgagggcc cggaaacctg gccctgtctt cttgacgagc     1680

attcctaggg gtctttcccc tctcgccaaa ggaatgcaag gtctgttgaa tgtcgtgaag     1740

gaagcagttc ctctggaagc ttcttgaaga caaacaacgt ctgtagcgac cctttgcagg     1800

cagcggaacc ccccacctgg cgacaggtgc ctctgcggcc aaaagccacg tgtataagat     1860

acacctgcaa aggcggcaca accccagtgc cacgttgtga gttggatagt tgtggaaaga     1920

gtcaaatggc tctcctcaag cgtattcaac aaggggctga aggatgccca gaaggtaccc     1980

cattgtatgg gatctgatct ggggcctcgg tgcacatgct ttacatgtgt ttagtcgagg     2040

ttaaaaaaac gtctaggccc cccgaaccac ggggacgtgg ttttcctttg aaaaacacga     2100

tgataatatg gccacaacca tggagacaga tacactgctg ctgtgggtgc tgctcctctg     2160

ggtgccagga tctacaggcg aggttcagct gcagcagtct ggacctgagc tggttaagcc     2220

tggcgcctcc gtgaagatct cctgcaagac ctctggcttc accttcaccg agtactccat     2280

gcactgggtc aagcagtccc acggcaagtc cctggaatgg atcggcggca tcaaccctaa     2340

caacggcggc acctcctaca accagaagtt caagggcaaa gctaccctga ccgtggacaa     2400

gtcctcctcc accgcctaca tggaactgcg gtccctgacc tctgaggact ccgccgtgta     2460

ctactgcgct agagagtctt ggggccaggg caccacactg acagtctctt ctgcttctac     2520

caagggaccc agcgtgttcc ctctggctcc ttccagcaag tctacctctg gcggaacagc     2580

tgctctgggc tgcctggtca aggactactt tcctgagcct gtgaccgtgt cttggaactc     2640

tggcgctctg acatccggcg tgcacacctt tccagctgtg ctgcaatcca gcggcctgta     2700

ctctctgtcc tccgtcgtga ccgtgccttc tagctctctg ggcacacaga cctacatctg     2760

caatgtgaac cacaagcctt ccaacaccaa ggtggacaag aaggtggaac ccaagtcctg     2820

cgacaagacc cacacctgtc ctccatgtcc tgctccagaa ctgctcggcg gaccttccgt     2880

gttcctgttt cctccaaagc ctaaggacac cctgatgatc tctcggaccc ctgaagtgac     2940

ctgcgtggtg gtggatgtgt ctcacgagga tcccgaagtg aagttcaatt ggtacgtgga     3000

cggcgtggaa gtgcacaacg ccaagaccaa gcctagagag gaacagtaca actccaccta     3060

cagagtggtg tccgtgctga ccgtgctgca ccaggattgg ctgaacggca aagagtacaa     3120

gtgcaaggtg tccaacaagg ccctgcctgc tcctatcgaa aagaccatct ccaaggccaa     3180

gggccagcct agggaacccc aggtttacac cttgcctcca tctcgggaag agatgaccaa     3240

gaaccaggtg tccctgacct gtctcgtgaa gggcttctac ccctccgata tcgccgtgga     3300

atgggagtct aatggccagc ctgagaacaa ctacaagaca acccctcctg tgctggactc     3360

cgacggctca ttcttcctgt actccaagct gacagtggac aagtccagat ggcagcaggg     3420

caacgtgttc tcctgctccg tgatgcacga ggccctgcac aatcactaca cccagaagtc     3480

cctgtctctg agccccggca agtagcaact ttattataca tagttggaat tccgataatc     3540

aacctctgga ttacaaaatt tgtgaaagat tgactggtat tcttaactat gttgctcctt     3600

ttacgctatg tggatacgct gctttaatgc ctttgtatca tgctattgct tcccgtatgg     3660

ctttcatttt ctcctccttg tataaatcct ggttgctgtc tctttatgag gagttgtggc     3720

ccgttgtcag gcaacgtggc gtggtgtgca ctgtgtttgc tgacgcaacc cccactggtt     3780

ggggcattgc caccacctgt cagctccttt ccgggacttt cgctttcccc ctccctattg     3840

ccacggcgga actcatcgcc gcctgccttg cccgctgctg gacaggggct cggctgttgg     3900

gcactgacaa ttccgtggtg ttgtcgggga agctgacgtc ctttccatgg ctgctcgcct     3960

gtgttgccac ctggattctg cgcgggacgt ccttctgcta cgtcccttcg gccctcaatc     4020

cagcggacct tccttcccgc ggcctgctgc cggctctgcg gcctcttccg cgtcttcgcc     4080

ttcgccctca gacgagtcgg atctcccttt gggccgcctc cccgcatcgg gaattcctag     4140

agctcgctga tcagcctcga ctgtgccttc tagttgccag ccatctgttg tttgcccctc     4200

ccccgtgcct tccttgaccc tggaaggtgc cactcccact gtcctttcct aataaaatga     4260

ggaaattgca tcgcattgtc tgagtaggtg tcattctatt ctggggggtg gggtggggca     4320

ggacagcaag ggggaggatt gggaagagaa tagcaggcat gctggggagg gccgcaggaa     4380

cccctagtga tggagttggc cactccctct ctgcgcgctc gctcgctcac tgaggccggg     4440

cgaccaaagg tcgcccgacg cccgggcttt gcccgggcgg cctcagtgag cgagcgagcg     4500

cgcagctgcc tgcagg                                                     4516


<210>  6
<211>  4141
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MAB1 - 2 promoters IgG, consisting of promoter 1 
       (CMV)-LC-polyA-promoter 2 (CMV)-HC-WPRE-poly A

<400>  6
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc ttctagacaa ctttgtatag aaaagttgta gttattaata      180

gtaatcaatt acggggtcat tagttcatag cccatatatg gagttccgcg ttacataact      240

tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga cgtcaataat      300

gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggagta      360

tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa gtacgccccc      420

tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttatg      480

ggactttcct acttggcagt acatctacgt attagtcatc gctattacca tggtgatgcg      540

gttttggcag tacatcaatg ggcgtggata gcggtttgac tcacggggat ttccaagtct      600

ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg actttccaaa      660

atgtcgtaac aactccgccc cattgacgca aatgggcggt aggcgtgtac ggtgggaggt      720

ctatataagc agagctggtt tagtgaaccg tcagatccaa gtttgtacaa aaaagcaggc      780

tgccaccatg gagacagata cactgctgct gtgggtgctg ctcctctggg tgccaggatc      840

tacaggcgac gtggtcatga cacagacccc tctgacactg tccgtgacca tcggacagcc      900

tgcctccatc tcctgcaagt cctctcagtc cctgctgcac tctgacggca agacctacct      960

gaactggctg ctgcagaggc ctggccagag tcctaagaga ctgatctacc tggtgtccaa     1020

gctggactct cggatccctg acagattcac cggctctggc tctggcaccg acttcaccct     1080

gaagatctcc agagtggaag ccgaggacct gggcgtgtac tactgttggc agggcaccca     1140

ctttccacac acctttggcg ctggcacaaa gctggaactg aagcggacag tggccgctcc     1200

ttccgtgttc atcttcccac cttccgacga gcagctgaag tccggcacag cttctgtcgt     1260

gtgcctgctg aacaacttct accctcggga agccaaggtg cagtggaagg tggacaatgc     1320

cctgcagtcc ggcaactccc aagagtctgt gaccgagcag gactccaagg acagcaccta     1380

cagcctgtcc tccacactga ccctgtccaa ggccgactac gagaagcaca aggtgtacgc     1440

ctgcgaagtg acccatcagg gcctgtctag ccctgtgacc aagtctttca accggggcga     1500

gtgttgacag acatgataag atacattgat gagtttggac aaaccacaac tagaatgcag     1560

tgaaaaaaat gctttatttg tgaaatttgt gatgctattg ctttatttgt aaccattata     1620

agctgcaata aacaagttaa caacaacaat tgcattcatt ttatgtttca ggttcagggg     1680

gaggtgtggg aggtttttta aagcaagtaa aacctctaca aatgtggtat agttattaat     1740

agtaatcaat tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac     1800

ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa     1860

tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt     1920

atttacggta aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc     1980

ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat     2040

gggactttcc tacttggcag tacatctacg tattagtcat cgctattacc atggtgatgc     2100

ggttttggca gtacatcaat gggcgtggat agcggtttga ctcacgggga tttccaagtc     2160

tccaccccat tgacgtcaat gggagtttgt tttggcacca aaatcaacgg gactttccaa     2220

aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg taggcgtgta cggtgggagg     2280

tctatataag cagagctggt ttagtgaacc gtcagatcac ccagctttct tgtacaaagt     2340

gggccaccat ggagacagat acactgctgc tgtgggtgct gctcctctgg gtgccaggat     2400

ctacaggcga ggttcagctg cagcagtctg gacctgagct ggttaagcct ggcgcctccg     2460

tgaagatctc ctgcaagacc tctggcttca ccttcaccga gtactccatg cactgggtca     2520

agcagtccca cggcaagtcc ctggaatgga tcggcggcat caaccctaac aacggcggca     2580

cctcctacaa ccagaagttc aagggcaaag ctaccctgac cgtggacaag tcctcctcca     2640

ccgcctacat ggaactgcgg tccctgacct ctgaggactc cgccgtgtac tactgcgcta     2700

gagagtcttg gggccagggc accacactga cagtctcttc tgcttctacc aagggaccca     2760

gcgtgttccc tctggctcct tccagcaagt ctacctctgg cggaacagct gctctgggct     2820

gcctggtcaa ggactacttt cctgagcctg tgaccgtgtc ttggaactct ggcgctctga     2880

catccggcgt gcacaccttt ccagctgtgc tgcaatccag cggcctgtac tctctgtcct     2940

ccgtcgtgac cgtgccttct agctctctgg gcacacagac ctacatctgc aatgtgaacc     3000

acaagccttc caacaccaag gtggacaaga aggtggaacc caagtcctgc gacaagaccc     3060

acacctgtcc tccatgtcct gctccagaac tgctcggcgg accttccgtg ttcctgtttc     3120

ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc tgcgtggtgg     3180

tggatgtgtc tcacgaggat cccgaagtga agttcaattg gtacgtggac ggcgtggaag     3240

tgcacaacgc caagaccaag cctagagagg aacagtacaa ctccacctac agagtggtgt     3300

ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag tgcaaggtgt     3360

ccaacaaggc cctgcctgct cctatcgaaa agaccatctc caaggccaag ggccagccta     3420

gggaacccca ggtttacacc ttgcctccat ctcgggaaga gatgaccaag aaccaggtgt     3480

ccctgacctg tctcgtgaag ggcttctacc cctccgatat cgccgtggaa tgggagtcta     3540

atggccagcc tgagaacaac tacaagacaa cccctcctgt gctggactcc gacggctcat     3600

tcttcctgta ctccaagctg acagtggaca agtccagatg gcagcagggc aacgtgttct     3660

cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc ctgtctctga     3720

gccccggcaa gtagcaactt tattatacat agttggaatt cctagagctc gctgatcagc     3780

ctcgactgtg ccttctagtt gccagccatc tgttgtttgc ccctcccccg tgccttcctt     3840

gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca     3900

ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga     3960

ggattgggaa gagaatagca ggcatgctgg ggagggccgc aggaacccct agtgatggag     4020

ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc     4080

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag ctgcctgcag     4140

g                                                                     4141


<210>  7
<211>  3274
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MAB1, promoter-scFv-Fc-WPRE

<400>  7
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc ttctagacaa ctttgtatag aaaagttgta gttattaata      180

gtaatcaatt acggggtcat tagttcatag cccatatatg gagttccgcg ttacataact      240

tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga cgtcaataat      300

gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggagta      360

tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa gtacgccccc      420

tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttatg      480

ggactttcct acttggcagt acatctacgt attagtcatc gctattacca tggtgatgcg      540

gttttggcag tacatcaatg ggcgtggata gcggtttgac tcacggggat ttccaagtct      600

ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg actttccaaa      660

atgtcgtaac aactccgccc cattgacgca aatgggcggt aggcgtgtac ggtgggaggt      720

ctatataagc agagctggtt tagtgaaccg tcagatccaa gtttgtacaa aaaagcaggc      780

tgccaccatg gagacagata cactgctgct gtgggtgctg ctcctctggg tgccaggatc      840

tacaggcgag gttcagctgc agcagtctgg acctgagctg gttaagcctg gcgcctccgt      900

gaagatctcc tgcaagacct ctggcttcac cttcaccgag tactccatgc actgggtcaa      960

gcagtcccac ggcaagtccc tggaatggat cggcggcatc aaccctaaca acggcggcac     1020

ctcctacaac cagaagttca agggcaaagc taccctgacc gtggacaagt cctcctccac     1080

cgcctacatg gaactgcggt ccctgacctc tgaggactcc gccgtgtact actgcgctag     1140

agagtcttgg ggccagggca ccacactgac agtctcttct ggaggcggag gatctggcgg     1200

aggtggaagt ggcggaggcg gatctgacgt ggtcatgaca cagacccctc tgacactgtc     1260

cgtgaccatc ggacagcctg cctccatctc ctgcaagtcc tctcagtccc tgctgcactc     1320

tgacggcaag acctacctga actggctgct gcagaggcct ggccagagtc ctaagagact     1380

gatctacctg gtgtccaagc tggactctcg gatccctgac agattcaccg gctctggctc     1440

tggcaccgac ttcaccctga agatctccag agtggaagcc gaggacctgg gcgtgtacta     1500

ctgttggcag ggcacccact ttccacacac ctttggcgct ggcacaaagc tggaactgaa     1560

gggaggcgga ggatctgaca agacccacac ctgtcctcca tgtcctgctc cagaactgct     1620

cggcggacct tccgtgttcc tgtttcctcc aaagcctaag gacaccctga tgatctctcg     1680

gacccctgaa gtgacctgcg tggtggtgga tgtgtctcac gaggatcccg aagtgaagtt     1740

caattggtac gtggacggcg tggaagtgca caacgccaag accaagccta gagaggaaca     1800

gtacaactcc acctacagag tggtgtccgt gctgaccgtg ctgcaccagg attggctgaa     1860

cggcaaagag tacaagtgca aggtgtccaa caaggccctg cctgctccta tcgaaaagac     1920

catctccaag gccaagggcc agcctaggga accccaggtt tacaccttgc ctccatctcg     1980

ggaagagatg accaagaacc aggtgtccct gacctgtctc gtgaagggct tctacccctc     2040

cgatatcgcc gtggaatggg agtctaatgg ccagcctgag aacaactaca agacaacccc     2100

tcctgtgctg gactccgacg gctcattctt cctgtactcc aagctgacag tggacaagtc     2160

cagatggcag cagggcaacg tgttctcctg ctccgtgatg cacgaggccc tgcacaatca     2220

ctacacccag aagtccctgt ctctgagccc cggcaagtag acccagcttt cttgtacaaa     2280

gtgggaattc cgataatcaa cctctggatt acaaaatttg tgaaagattg actggtattc     2340

ttaactatgt tgctcctttt acgctatgtg gatacgctgc tttaatgcct ttgtatcatg     2400

ctattgcttc ccgtatggct ttcattttct cctccttgta taaatcctgg ttgctgtctc     2460

tttatgagga gttgtggccc gttgtcaggc aacgtggcgt ggtgtgcact gtgtttgctg     2520

acgcaacccc cactggttgg ggcattgcca ccacctgtca gctcctttcc gggactttcg     2580

ctttccccct ccctattgcc acggcggaac tcatcgccgc ctgccttgcc cgctgctgga     2640

caggggctcg gctgttgggc actgacaatt ccgtggtgtt gtcggggaag ctgacgtcct     2700

ttccatggct gctcgcctgt gttgccacct ggattctgcg cgggacgtcc ttctgctacg     2760

tcccttcggc cctcaatcca gcggaccttc cttcccgcgg cctgctgccg gctctgcggc     2820

ctcttccgcg tcttcgcctt cgccctcaga cgagtcggat ctccctttgg gccgcctccc     2880

cgcatcggga attcctagag ctcgctgatc agcctcgact gtgccttcta gttgccagcc     2940

atctgttgtt tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt     3000

cctttcctaa taaaatgagg aaattgcatc gcattgtctg agtaggtgtc attctattct     3060

ggggggtggg gtggggcagg acagcaaggg ggaggattgg gaagagaata gcaggcatgc     3120

tggggagggc cgcaggaacc cctagtgatg gagttggcca ctccctctct gcgcgctcgc     3180

tcgctcactg aggccgggcg accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc     3240

tcagtgagcg agcgagcgcg cagctgcctg cagg                                 3274


<210>  8
<211>  576
<212>  DNA
<213>  Encephalomyocarditis virus

<400>  8
gcccctctcc ctcccccccc cctaacgtta ctggccgaag ccgcttggaa taaggccggt       60

gtgcgtttgt ctatatgtta ttttccacca tattgccgtc ttttggcaat gtgagggccc      120

ggaaacctgg ccctgtcttc ttgacgagca ttcctagggg tctttcccct ctcgccaaag      180

gaatgcaagg tctgttgaat gtcgtgaagg aagcagttcc tctggaagct tcttgaagac      240

aaacaacgtc tgtagcgacc ctttgcaggc agcggaaccc cccacctggc gacaggtgcc      300

tctgcggcca aaagccacgt gtataagata cacctgcaaa ggcggcacaa ccccagtgcc      360

acgttgtgag ttggatagtt gtggaaagag tcaaatggct ctcctcaagc gtattcaaca      420

aggggctgaa ggatgcccag aaggtacccc attgtatggg atctgatctg gggcctcggt      480

gcacatgctt tacatgtgtt tagtcgaggt taaaaaaacg tctaggcccc ccgaaccacg      540

gggacgtggt tttcctttga aaaacacgat gataat                                576


<210>  9
<211>  3859
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MAB1 FAB promoter-LC-IRES-HC-WPRE-PolyA

<400>  9
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc ttctagacaa ctttgtatag aaaagttgta gttattaata      180

gtaatcaatt acggggtcat tagttcatag cccatatatg gagttccgcg ttacataact      240

tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga cgtcaataat      300

gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggagta      360

tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa gtacgccccc      420

tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttatg      480

ggactttcct acttggcagt acatctacgt attagtcatc gctattacca tggtgatgcg      540

gttttggcag tacatcaatg ggcgtggata gcggtttgac tcacggggat ttccaagtct      600

ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg actttccaaa      660

atgtcgtaac aactccgccc cattgacgca aatgggcggt aggcgtgtac ggtgggaggt      720

ctatataagc agagctggtt tagtgaaccg tcagatccaa gtttgtacaa aaaagcaggc      780

tgccaccatg gagacagata cactgctgct gtgggtgctg ctcctctggg tgccaggatc      840

tacaggcgac gtggtcatga cacagacccc tctgacactg tccgtgacca tcggacagcc      900

tgcctccatc tcctgcaagt cctctcagtc cctgctgcac tctgacggca agacctacct      960

gaactggctg ctgcagaggc ctggccagag tcctaagaga ctgatctacc tggtgtccaa     1020

gctggactct cggatccctg acagattcac cggctctggc tctggcaccg acttcaccct     1080

gaagatctcc agagtggaag ccgaggacct gggcgtgtac tactgttggc agggcaccca     1140

ctttccacac acctttggcg ctggcacaaa gctggaactg aagcggacag tggccgctcc     1200

ttccgtgttc atcttcccac cttccgacga gcagctgaag tccggcacag cttctgtcgt     1260

gtgcctgctg aacaacttct accctcggga agccaaggtg cagtggaagg tggacaatgc     1320

cctgcagtcc ggcaactccc aagagtctgt gaccgagcag gactccaagg acagcaccta     1380

cagcctgtcc tccacactga ccctgtccaa ggccgactac gagaagcaca aggtgtacgc     1440

ctgcgaagtg acccatcagg gcctgtctag ccctgtgacc aagtctttca accggggcga     1500

gtgttgaacc cagctttctt gtacaaagtg ggcccctctc cctccccccc ccctaacgtt     1560

actggccgaa gccgcttgga ataaggccgg tgtgcgtttg tctatatgtt attttccacc     1620

atattgccgt cttttggcaa tgtgagggcc cggaaacctg gccctgtctt cttgacgagc     1680

attcctaggg gtctttcccc tctcgccaaa ggaatgcaag gtctgttgaa tgtcgtgaag     1740

gaagcagttc ctctggaagc ttcttgaaga caaacaacgt ctgtagcgac cctttgcagg     1800

cagcggaacc ccccacctgg cgacaggtgc ctctgcggcc aaaagccacg tgtataagat     1860

acacctgcaa aggcggcaca accccagtgc cacgttgtga gttggatagt tgtggaaaga     1920

gtcaaatggc tctcctcaag cgtattcaac aaggggctga aggatgccca gaaggtaccc     1980

cattgtatgg gatctgatct ggggcctcgg tgcacatgct ttacatgtgt ttagtcgagg     2040

ttaaaaaaac gtctaggccc cccgaaccac ggggacgtgg ttttcctttg aaaaacacga     2100

tgataatatg gccacaacca tggagacaga tacactgctg ctgtgggtgc tgctcctctg     2160

ggtgccagga tctacaggcg aggttcagct gcagcagtct ggacctgagc tggttaagcc     2220

tggcgcctcc gtgaagatct cctgcaagac ctctggcttc accttcaccg agtactccat     2280

gcactgggtc aagcagtccc acggcaagtc cctggaatgg atcggcggca tcaaccctaa     2340

caacggcggc acctcctaca accagaagtt caagggcaaa gctaccctga ccgtggacaa     2400

gtcctcctcc accgcctaca tggaactgcg gtccctgacc tctgaggact ccgccgtgta     2460

ctactgcgct agagagtctt ggggccaggg caccacactg acagtctctt ctgcttctac     2520

caagggaccc agcgtgttcc ctctggctcc ttccagcaag tctacctctg gcggaacagc     2580

tgctctgggc tgcctggtca aggactactt tcctgagcct gtgaccgtgt cttggaactc     2640

tggcgctctg acatccggcg tgcacacctt tccagctgtg ctgcaatcca gcggcctgta     2700

ctctctgtcc tccgtcgtga ccgtgccttc tagctctctg ggcacacaga cctacatctg     2760

caatgtgaac cacaagcctt ccaacaccaa ggtggacaag aaggtggaac ccaagtcctg     2820

cggctcccac caccatcacc atcattagca actttattat acatagttgg aattccgata     2880

atcaacctct ggattacaaa atttgtgaaa gattgactgg tattcttaac tatgttgctc     2940

cttttacgct atgtggatac gctgctttaa tgcctttgta tcatgctatt gcttcccgta     3000

tggctttcat tttctcctcc ttgtataaat cctggttgct gtctctttat gaggagttgt     3060

ggcccgttgt caggcaacgt ggcgtggtgt gcactgtgtt tgctgacgca acccccactg     3120

gttggggcat tgccaccacc tgtcagctcc tttccgggac tttcgctttc cccctcccta     3180

ttgccacggc ggaactcatc gccgcctgcc ttgcccgctg ctggacaggg gctcggctgt     3240

tgggcactga caattccgtg gtgttgtcgg ggaagctgac gtcctttcca tggctgctcg     3300

cctgtgttgc cacctggatt ctgcgcggga cgtccttctg ctacgtccct tcggccctca     3360

atccagcgga ccttccttcc cgcggcctgc tgccggctct gcggcctctt ccgcgtcttc     3420

gccttcgccc tcagacgagt cggatctccc tttgggccgc ctccccgcat cgggaattcc     3480

tagagctcgc tgatcagcct cgactgtgcc ttctagttgc cagccatctg ttgtttgccc     3540

ctcccccgtg ccttccttga ccctggaagg tgccactccc actgtccttt cctaataaaa     3600

tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct attctggggg gtggggtggg     3660

gcaggacagc aagggggagg attgggaaga gaatagcagg catgctgggg agggccgcag     3720

gaacccctag tgatggagtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc     3780

gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga     3840

gcgcgcagct gcctgcagg                                                  3859


<210>  10
<211>  4088
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MAB1 Fab - 2 promoters IgG, consisting of promoter 1 
       (CMV)-HC-polyA-promoter 2 (CMV)-LC-WPRE-poly A

<400>  10
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc ttctagacaa ctttgtatag aaaagttgta gttattaata      180

gtaatcaatt acggggtcat tagttcatag cccatatatg gagttccgcg ttacataact      240

tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga cgtcaataat      300

gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggagta      360

tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa gtacgccccc      420

tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttatg      480

ggactttcct acttggcagt acatctacgt attagtcatc gctattacca tggtgatgcg      540

gttttggcag tacatcaatg ggcgtggata gcggtttgac tcacggggat ttccaagtct      600

ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg actttccaaa      660

atgtcgtaac aactccgccc cattgacgca aatgggcggt aggcgtgtac ggtgggaggt      720

ctatataagc agagctggtt tagtgaaccg tcagatccaa gtttgtacaa aaaagcaggc      780

tgccaccatg gagacagata cactgctgct gtgggtgctg ctcctctggg tgccaggatc      840

tacaggcgag gttcagctgc agcagtctgg acctgagctg gttaagcctg gcgcctccgt      900

gaagatctcc tgcaagacct ctggcttcac cttcaccgag tactccatgc actgggtcaa      960

gcagtcccac ggcaagtccc tggaatggat cggcggcatc aaccctaaca acggcggcac     1020

ctcctacaac cagaagttca agggcaaagc taccctgacc gtggacaagt cctcctccac     1080

cgcctacatg gaactgcggt ccctgacctc tgaggactcc gccgtgtact actgcgctag     1140

agagtcttgg ggccagggca ccacactgac agtctcttct gcttctacca agggacccag     1200

cgtgttccct ctggctcctt ccagcaagtc tacctctggc ggaacagctg ctctgggctg     1260

cctggtcaag gactactttc ctgagcctgt gaccgtgtct tggaactctg gcgctctgac     1320

atccggcgtg cacacctttc cagctgtgct gcaatccagc ggcctgtact ctctgtcctc     1380

cgtcgtgacc gtgccttcta gctctctggg cacacagacc tacatctgca atgtgaacca     1440

caagccttcc aacaccaagg tggacaagaa ggtggaaccc aagtcctgcg gctcccacca     1500

ccatcaccat cattagcaga catgataaga tacattgatg agtttggaca aaccacaact     1560

agaatgcagt gaaaaaaatg ctttatttgt gaaatttgtg atgctattgc tttatttgta     1620

accattataa gctgcaataa acaagttaac aacaacaatt gcattcattt tatgtttcag     1680

gttcaggggg aggtgtggga ggttttttaa agcaagtaaa acctctacaa atgtggtata     1740

gttattaata gtaatcaatt acggggtcat tagttcatag cccatatatg gagttccgcg     1800

ttacataact tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga     1860

cgtcaataat gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat     1920

gggtggagta tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa     1980

gtacgccccc tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca     2040

tgaccttatg ggactttcct acttggcagt acatctacgt attagtcatc gctattacca     2100

tggtgatgcg gttttggcag tacatcaatg ggcgtggata gcggtttgac tcacggggat     2160

ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg     2220

actttccaaa atgtcgtaac aactccgccc cattgacgca aatgggcggt aggcgtgtac     2280

ggtgggaggt ctatataagc agagctggtt tagtgaaccg tcagatcacc cagctttctt     2340

gtacaaagtg ggccaccatg gagacagata cactgctgct gtgggtgctg ctcctctggg     2400

tgccaggatc tacaggcgac gtggtcatga cacagacccc tctgacactg tccgtgacca     2460

tcggacagcc tgcctccatc tcctgcaagt cctctcagtc cctgctgcac tctgacggca     2520

agacctacct gaactggctg ctgcagaggc ctggccagag tcctaagaga ctgatctacc     2580

tggtgtccaa gctggactct cggatccctg acagattcac cggctctggc tctggcaccg     2640

acttcaccct gaagatctcc agagtggaag ccgaggacct gggcgtgtac tactgttggc     2700

agggcaccca ctttccacac acctttggcg ctggcacaaa gctggaactg aagcggacag     2760

tggccgctcc ttccgtgttc atcttcccac cttccgacga gcagctgaag tccggcacag     2820

cttctgtcgt gtgcctgctg aacaacttct accctcggga agccaaggtg cagtggaagg     2880

tggacaatgc cctgcagtcc ggcaactccc aagagtctgt gaccgagcag gactccaagg     2940

acagcaccta cagcctgtcc tccacactga ccctgtccaa ggccgactac gagaagcaca     3000

aggtgtacgc ctgcgaagtg acccatcagg gcctgtctag ccctgtgacc aagtctttca     3060

accggggcga gtgttgacaa ctttattata catagttgga attccgataa tcaacctctg     3120

gattacaaaa tttgtgaaag attgactggt attcttaact atgttgctcc ttttacgcta     3180

tgtggatacg ctgctttaat gcctttgtat catgctattg cttcccgtat ggctttcatt     3240

ttctcctcct tgtataaatc ctggttgctg tctctttatg aggagttgtg gcccgttgtc     3300

aggcaacgtg gcgtggtgtg cactgtgttt gctgacgcaa cccccactgg ttggggcatt     3360

gccaccacct gtcagctcct ttccgggact ttcgctttcc ccctccctat tgccacggcg     3420

gaactcatcg ccgcctgcct tgcccgctgc tggacagggg ctcggctgtt gggcactgac     3480

aattccgtgg tgttgtcggg gaagctgacg tcctttccat ggctgctcgc ctgtgttgcc     3540

acctggattc tgcgcgggac gtccttctgc tacgtccctt cggccctcaa tccagcggac     3600

cttccttccc gcggcctgct gccggctctg cggcctcttc cgcgtcttcg ccttcgccct     3660

cagacgagtc ggatctccct ttgggccgcc tccccgcatc gggaattcct agagctcgct     3720

gatcagcctc gactgtgcct tctagttgcc agccatctgt tgtttgcccc tcccccgtgc     3780

cttccttgac cctggaaggt gccactccca ctgtcctttc ctaataaaat gaggaaattg     3840

catcgcattg tctgagtagg tgtcattcta ttctgggggg tggggtgggg caggacagca     3900

agggggagga ttgggaagag aatagcaggc atgctgggga gggccgcagg aacccctagt     3960

gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa     4020

ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag cgcgcagctg     4080

cctgcagg                                                              4088


<210>  11
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Expected LC C-terminal sequence

<400>  11

Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
1               5                   10                  15      


Lys Ser Phe Asn Arg Gly Glu Cys 
            20                  


<210>  12
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analyzed LC C-terminal sequence

<400>  12

Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
1               5                   10                  15      


Lys Ser Phe Asn Arg Gly Glu Cys Arg Lys Arg Arg Ser Gly Ser Gly 
            20                  25                  30          


Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
        35                  40                  45              


Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr Asp Thr Leu Leu Leu 
    50                  55                  60                  


<210>  13
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Expected HC C-terminal sequence

<400>  13

Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
1               5                   10                  15      


Ser Pro Gly Lys 
            20  


<210>  14
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analyzed HC C-terminal sequence

<400>  14

Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
1               5                   10                  15      


Ser Pro Gly Lys Arg Lys Arg Arg Ser Gly Ser Gly Ala Pro Val Lys 
            20                  25                  30          


Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
        35                  40                  45              


Asn Pro Gly Pro Met Glu Thr Asp Thr Leu Leu 
    50                  55                  


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BBB targeting peptide

<400>  15

Asn Arg Gly Thr Glu Trp Asp 
1               5           


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  core sequence motif of self-cleavage peptides is the 2A peptide 
       family


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  16

Asp Xaa Glu Xaa Asn Pro Gly Pro 
1               5               


