                         SEQUENCE LISTING

<110>  Novo Nordisk A/S
 
<120>  Co-agonists of the GLP-1 and Amylin Receptors

<130>  200062WO01

<150>  EP20215291.4
<151>  2020-12-18

<150>  EP21154668.4
<151>  2021-02-02

<150>  EP21179810.3
<151>  2021-06-16

<160>  256   

<170>  PatentIn version 3.5

<210>  1
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  1

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  2
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  2

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  3
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  3

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Gly 
            20                  25                  30      


<210>  4
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  4

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  5
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is Imp (imidazole propionyl)

<400>  5

Xaa Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Lys 
            20                  25                  30      


<210>  6
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist

<400>  6

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Glu Trp Leu Val Arg Gly Lys Gly 
            20                  25                  30      


<210>  7
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  7

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Lys 
            20                  25                  30      


<210>  8
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  8

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  9
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  9

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  10
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  10

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Gly 
            20                  25                  30      


<210>  11
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  11

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Ala Trp Leu Val Arg Gly Lys Gly 
            20                  25                  30      


<210>  12
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  12

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  13
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  13

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Lys 
            20                  25                  30      


<210>  14
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  14

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Glu Trp Leu Val Arg Gly Lys Gly 
            20                  25                  30      


<210>  15
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  15

His Trp Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Glu Trp Leu Val Arg Gly Lys Gly 
            20                  25                  30      


<210>  16
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  16

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly 
            20                  25                  


<210>  17
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  17

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Lys 
            20                  25                  30      


<210>  18
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  18

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Ala Trp Leu Val Arg Gly Arg Lys 
            20                  25                  30      


<210>  19
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is Imp (imidazole propionyl)

<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  19

Xaa Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Lys 
            20                  25                  30      


<210>  20
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  20

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Glu Trp Leu Val Arg Gly Arg Lys 
            20                  25                  30      


<210>  21
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  21

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Gly 
            20                  25                  30      


<210>  22
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  22

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  23
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  23

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  24
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  24

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Glu Trp Leu Val Arg Gly Lys Gly 
            20                  25                  30      


<210>  25
<211>  30
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  25

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Glu Trp Leu Val Arg Gly Lys 
            20                  25                  30  


<210>  26
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  26

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Glu Trp Leu Val Arg Gly Arg Lys 
            20                  25                  30      


<210>  27
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist

<400>  27

His Trp Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Glu Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  28
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist

<400>  28

His Trp Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Glu Trp Leu Val Arg Gly Lys Gly 
            20                  25                  30      


<210>  29
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  29

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Lys 
            20                  25                  30      


<210>  30
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  30

His Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  31
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  31

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Lys Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  32
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist

<400>  32

His Trp Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Lys 
            20                  25                  30      


<210>  33
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist

<400>  33

His Trp Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Glu Trp Leu Val Arg Gly Arg Lys 
            20                  25                  30      


<210>  34
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist

<400>  34

His Trp Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Lys Ala Ala Arg Glu Phe Ile Glu Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  35
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist

<400>  35

His Trp Glu Gly Thr Phe Thr Ser Asp Lys Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Glu Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  36
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  36

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Lys 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  37
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  37

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Lys Arg Gly 
            20                  25                  30      


<210>  38
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist

<400>  38

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Lys Ala Ala Arg Glu Phe Ile Glu Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  39
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  39

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Lys Ala Ala Arg Glu Phe Ile Glu Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  40
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist

<400>  40

His Ala Glu Gly Thr Phe Thr Ser Lys Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Glu Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  41
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  41

His Xaa Glu Gly Thr Phe Thr Ser Lys Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Glu Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  42
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist

<400>  42

His Ala Glu Gly Thr Phe Thr Ser Asp Lys Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Glu Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  43
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist

<400>  43

His Trp Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Glu Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  44
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  44

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Glu Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  45
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  45

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Glu Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  46
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  46

His Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Glu Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  47
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist

<400>  47

His Ala Glu Gly Thr Phe Thr Ser Asp Lys Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Lys Ala Ala Arg Glu Phe Ile Glu Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  48
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist

<400>  48

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Val Arg Glu Phe Ile Ala Lys Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  49
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  49

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Val Arg Glu Phe Ile Ala Lys Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  50
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  50

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Pro 
            20                  25                  30      


<210>  51
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  51

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Arg Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Glu Trp Leu Val Arg Gly Arg Lys 
            20                  25                  30      


<210>  52
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  52

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  53
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  53

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  54
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  54

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Lys 
            20                  25                  30      


<210>  55
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist

<400>  55

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  56
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  56

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Ala Trp Leu Val Arg Gly Arg Gln 
            20                  25                  30      


<210>  57
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  57

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Glu Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  58
<211>  30
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  58

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Ala Trp Leu Val Arg Gly Gly 
            20                  25                  30  


<210>  59
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  59

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Glu Trp Leu Val Arg Gly 
            20                  25                  


<210>  60
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  60

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Glu Trp Leu Val Arg Gly Ala Ala 
            20                  25                  30      


<210>  61
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  61

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Glu Trp Leu Val Arg Gly Ala Ala 
            20                  25                  30      


<210>  62
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  62

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Ala Trp Leu Val Arg Gly Arg Lys 
            20                  25                  30      


<210>  63
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  63

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Glu Trp Leu Val Arg Gly Arg Gln 
            20                  25                  30      


<210>  64
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  64

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Ile Phe Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  65
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  65

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Ile Phe Ala Trp Leu Val Arg Gly Arg Lys 
            20                  25                  30      


<210>  66
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  66

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Ile Phe Ala Trp Leu Val Arg Gly Arg Lys 
            20                  25                  30      


<210>  67
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist

<400>  67

His Trp Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Ile Phe Glu Trp Leu Val Arg Gly Lys Gly 
            20                  25                  30      


<210>  68
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  68

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Ile Phe Glu Trp Leu Val Arg Gly Lys Gly 
            20                  25                  30      


<210>  69
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  69

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Ile Phe Ala Trp Leu Val Arg Gly Lys Gly 
            20                  25                  30      


<210>  70
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  70

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Ile Phe Ala Trp Leu Val Arg Gly Arg Lys 
            20                  25                  30      


<210>  71
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  71

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Ile Phe Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  72
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist

<400>  72

His Ala Glu Gly Thr Phe Thr Ser Asp Lys Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Ile Phe Glu Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  73
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  73

His Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Ile Phe Glu Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  74
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist

<400>  74

His Trp Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Ile Phe Glu Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  75
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  75

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Arg Glu Ile Phe Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  76
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  76

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Ile Phe Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  77
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  77

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Ile Phe Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  78
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist

<400>  78

His Trp Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Ile Phe Ala Trp Leu Val Arg Gly Arg Lys 
            20                  25                  30      


<210>  79
<211>  32
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Amylin receptor agonist

<400>  79

Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu 
1               5                   10                  15      


His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
            20                  25                  30          


<210>  80
<211>  32
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Amylin receptor agonist

<400>  80

Arg Lys Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu 
1               5                   10                  15      


His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
            20                  25                  30          


<210>  81
<211>  32
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Amylin receptor agonist

<400>  81

Ala Ser Arg Leu Ser Thr Glu Ala Leu Gly Arg Leu Ser Ala Glu Leu 
1               5                   10                  15      


His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
            20                  25                  30          


<210>  82
<211>  32
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Amylin receptor agonist

<400>  82

Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Lys Glu Leu 
1               5                   10                  15      


His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
            20                  25                  30          


<210>  83
<211>  32
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Amylin receptor agonist

<400>  83

Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu 
1               5                   10                  15      


His Glu Leu Lys Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
            20                  25                  30          


<210>  84
<211>  32
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Amylin receptor agonist

<400>  84

Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu 
1               5                   10                  15      


His Lys Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
            20                  25                  30          


<210>  85
<211>  32
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Amylin receptor agonist

<400>  85

Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu 
1               5                   10                  15      


His Glu Leu Ala Thr Leu Lys Arg Thr Glu Thr Gly Ser Gly Ser Pro 
            20                  25                  30          


<210>  86
<211>  32
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Amylin receptor agonist

<400>  86

Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu 
1               5                   10                  15      


His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Lys Gly Ser Pro 
            20                  25                  30          


<210>  87
<211>  32
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Amylin receptor agonist

<400>  87

Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu 
1               5                   10                  15      


His Gln Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
            20                  25                  30          


<210>  88
<211>  32
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Amylin receptor agonist

<400>  88

Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Pro Ser Ala Glu Leu 
1               5                   10                  15      


His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
            20                  25                  30          


<210>  89
<211>  4
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Optional peptide linker

<400>  89

Glu Gly Gly Glu 
1               


<210>  90
<211>  4
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Optional peptide linker

<400>  90

Gly Gly Gly Glu 
1               


<210>  91
<211>  4
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Optional peptide linker

<400>  91

Gly Gly Gly Gly 
1               


<210>  92
<211>  4
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Optional peptide linker

<400>  92

Lys Gly Gly Gly 
1               


<210>  93
<211>  5
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Optional peptide linker

<400>  93

Glu Ala Glu Ala Glu 
1               5   


<210>  94
<211>  5
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Optional peptide linker

<400>  94

Gly Gly Gly Gly Glu 
1               5   


<210>  95
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Optional peptide linker

<400>  95

Glu Gly Glu Gly Glu Glu 
1               5       


<210>  96
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Optional peptide linker

<400>  96

Glu Gly Gly Gly Gly Gly 
1               5       


<210>  97
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Optional peptide linker

<400>  97

Lys Gly Gly Gly Gly Glu 
1               5       


<210>  98
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Optional peptide linker

<400>  98

Glu Gly Glu Gly Glu Lys Glu 
1               5           


<210>  99
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Optional peptide linker

<400>  99

Glu Gly Gly Gly Gly Gly Glu 
1               5           


<210>  100
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Optional peptide linker

<400>  100

Glu Gly Gln Glu Pro Gly Gly 
1               5           


<210>  101
<211>  8
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Optional peptide linker

<400>  101

Gln Glu Pro Gly Gln Ala Pro Glu 
1               5               


<210>  102
<211>  8
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Optional peptide linker

<400>  102

Gln Ala Pro Gly Gln Glu Pro Glu 
1               5               


<210>  103
<211>  8
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Optional peptide linker

<400>  103

Gln Glu Pro Lys Gly Gln Ala Pro 
1               5               


<210>  104
<211>  8
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Optional peptide linker

<400>  104

Gly Gly Gly Gly Gly Gly Gly Lys 
1               5               


<210>  105
<211>  9
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Optional peptide linker

<400>  105

Gly Gly Gly Gly Ser Gly Gly Gly Glu 
1               5                   


<210>  106
<211>  9
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Optional peptide linker

<400>  106

Gly Gln Glu Pro Gly Gln Glu Pro Glu 
1               5                   


<210>  107
<211>  9
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Optional peptide linker

<400>  107

Lys Gln Glu Pro Gly Gln Glu Pro Glu 
1               5                   


<210>  108
<211>  9
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Optional peptide linker

<400>  108

Gly Gln Glu Lys Gly Gln Glu Pro Glu 
1               5                   


<210>  109
<211>  9
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Optional peptide linker

<400>  109

Gln Glu Pro Gly Gln Ala Pro Lys Glu 
1               5                   


<210>  110
<211>  9
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Optional peptide linker

<400>  110

Gln Glu Pro Lys Gly Gln Ala Pro Glu 
1               5                   


<210>  111
<211>  9
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist

<400>  111

Gly Gly Gly Gly Gly Gly Gly Gly Glu 
1               5                   


<210>  112
<211>  10
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Optional peptide linker

<400>  112

Gly Gln Glu Pro Gly Gln Glu Pro Lys Glu 
1               5                   10  


<210>  113
<211>  10
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Optional peptide linker

<400>  113

Lys Gly Gln Glu Pro Gly Gln Ala Pro Glu 
1               5                   10  


<210>  114
<211>  11
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Optional peptide linker

<400>  114

Glu Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu 
1               5                   10      


<210>  115
<211>  13
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Optional peptide linker

<400>  115

Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu 
1               5                   10              


<210>  116
<211>  17
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Optional peptide linker

<400>  116

Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Glu 
    


<210>  117
<211>  66
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  117

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala 
        35                  40                  45              


Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly 
    50                  55                  60                  


Ser Pro 
65      


<210>  118
<211>  69
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  118

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Gly Glu 
            20                  25                  30          


Gly Glu Gly Glu Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg 
        35                  40                  45              


Leu Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr 
    50                  55                  60                  


Gly Ser Gly Ser Pro 
65                  


<210>  119
<211>  70
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  119

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Glu 
            20                  25                  30          


Gly Glu Gly Glu Lys Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly 
        35                  40                  45              


Arg Leu Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu 
    50                  55                  60                  


Thr Gly Ser Gly Ser Pro 
65                  70  


<210>  120
<211>  72
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  120

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Gln Glu Pro Gly Gln Glu Pro Glu Ala Ser Glu Leu Ser Thr Ala Ala 
        35                  40                  45              


Leu Gly Arg Leu Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg 
    50                  55                  60                  


Thr Glu Thr Gly Ser Gly Ser Pro 
65                  70          


<210>  121
<211>  71
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  121

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gln 
            20                  25                  30          


Glu Pro Gly Gln Ala Pro Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu 
        35                  40                  45              


Gly Arg Leu Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr 
    50                  55                  60                  


Glu Thr Gly Ser Gly Ser Pro 
65                  70      


<210>  122
<211>  64
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is Imp (imidazole propionyl)

<400>  122

Xaa Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Lys Glu 
            20                  25                  30          


Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu 
        35                  40                  45              


His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
    50                  55                  60                  


<210>  123
<211>  64
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist

<400>  123

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Glu Trp Leu Val Arg Gly Lys Gly Glu 
            20                  25                  30          


Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu 
        35                  40                  45              


His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
    50                  55                  60                  


<210>  124
<211>  67
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  124

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser 
        35                  40                  45              


Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser 
    50                  55                  60                  


Gly Ser Pro 
65          


<210>  125
<211>  66
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  125

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Lys Gly 
            20                  25                  30          


Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala 
        35                  40                  45              


Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly 
    50                  55                  60                  


Ser Pro 
65      


<210>  126
<211>  72
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  126

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala 
        35                  40                  45              


Leu Gly Arg Leu Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg 
    50                  55                  60                  


Thr Glu Thr Gly Ser Gly Ser Pro 
65                  70          


<210>  127
<211>  72
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  127

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Lys 
            20                  25                  30          


Gln Glu Pro Gly Gln Glu Pro Glu Ala Ser Glu Leu Ser Thr Ala Ala 
        35                  40                  45              


Leu Gly Arg Leu Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg 
    50                  55                  60                  


Thr Glu Thr Gly Ser Gly Ser Pro 
65                  70          


<210>  128
<211>  72
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  128

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Gln Glu Lys Gly Gln Glu Pro Glu Ala Ser Glu Leu Ser Thr Ala Ala 
        35                  40                  45              


Leu Gly Arg Leu Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg 
    50                  55                  60                  


Thr Glu Thr Gly Ser Gly Ser Pro 
65                  70          


<210>  129
<211>  73
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  129

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Gln Glu Pro Gly Gln Glu Pro Lys Glu Ala Ser Glu Leu Ser Thr Ala 
        35                  40                  45              


Ala Leu Gly Arg Leu Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro 
    50                  55                  60                  


Arg Thr Glu Thr Gly Ser Gly Ser Pro 
65                  70              


<210>  130
<211>  66
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  130

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Lys Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala 
        35                  40                  45              


Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly 
    50                  55                  60                  


Ser Pro 
65      


<210>  131
<211>  66
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  131

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Lys Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala 
        35                  40                  45              


Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly 
    50                  55                  60                  


Ser Pro 
65      


<210>  132
<211>  66
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  132

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Lys Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala 
        35                  40                  45              


Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly 
    50                  55                  60                  


Ser Pro 
65      


<210>  133
<211>  66
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  133

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Gly Gly 
            20                  25                  30          


Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala 
        35                  40                  45              


Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly 
    50                  55                  60                  


Ser Pro 
65      


<210>  134
<211>  66
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  134

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Ala Trp Leu Val Arg Gly Lys Gly Gly 
            20                  25                  30          


Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala 
        35                  40                  45              


Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly 
    50                  55                  60                  


Ser Pro 
65      


<210>  135
<211>  66
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  135

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Gly 
            20                  25                  30          


Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala 
        35                  40                  45              


Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly 
    50                  55                  60                  


Ser Pro 
65      


<210>  136
<211>  72
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  136

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Lys Gly 
            20                  25                  30          


Gln Glu Pro Gly Gln Ala Pro Glu Ala Ser Glu Leu Ser Thr Ala Ala 
        35                  40                  45              


Leu Gly Arg Leu Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg 
    50                  55                  60                  


Thr Glu Thr Gly Ser Gly Ser Pro 
65                  70          


<210>  137
<211>  72
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  137

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gln 
            20                  25                  30          


Glu Pro Lys Gly Gln Ala Pro Glu Ala Ser Glu Leu Ser Thr Ala Ala 
        35                  40                  45              


Leu Gly Arg Leu Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg 
    50                  55                  60                  


Thr Glu Thr Gly Ser Gly Ser Pro 
65                  70          


<210>  138
<211>  72
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  138

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gln 
            20                  25                  30          


Glu Pro Gly Gln Ala Pro Lys Glu Ala Ser Glu Leu Ser Thr Ala Ala 
        35                  40                  45              


Leu Gly Arg Leu Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg 
    50                  55                  60                  


Thr Glu Thr Gly Ser Gly Ser Pro 
65                  70          


<210>  139
<211>  67
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  139

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Glu Trp Leu Val Arg Gly Lys Gly Glu 
            20                  25                  30          


Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser 
        35                  40                  45              


Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser 
    50                  55                  60                  


Gly Ser Pro 
65          


<210>  140
<211>  67
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist

<400>  140

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Glu Trp Leu Val Arg Gly Lys Gly Glu 
            20                  25                  30          


Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser 
        35                  40                  45              


Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser 
    50                  55                  60                  


Gly Ser Pro 
65          


<210>  141
<211>  76
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  141

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Ala Ser Glu Leu 
        35                  40                  45              


Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu His Glu Leu Ala 
    50                  55                  60                  


Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
65                  70                  75      


<210>  142
<211>  80
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  142

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu 
        35                  40                  45              


Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu 
    50                  55                  60                  


His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
65                  70                  75                  80  


<210>  143
<211>  66
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist

<400>  143

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Glu Trp Leu Val Arg Gly Lys Gly Glu 
            20                  25                  30          


Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala 
        35                  40                  45              


Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly 
    50                  55                  60                  


Ser Pro 
65      


<210>  144
<211>  70
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist

<400>  144

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Glu Trp Leu Val Arg Gly Lys Gly Glu 
            20                  25                  30          


Gly Gly Gly Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly 
        35                  40                  45              


Arg Leu Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu 
    50                  55                  60                  


Thr Gly Ser Gly Ser Pro 
65                  70  


<210>  145
<211>  74
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist

<400>  145

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Glu Trp Leu Val Arg Gly Lys Gly Glu 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Ala Ser Glu Leu Ser Thr 
        35                  40                  45              


Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu His Glu Leu Ala Thr Leu 
    50                  55                  60                  


Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
65                  70                  


<210>  146
<211>  66
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist

<400>  146

His Trp Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Glu Trp Leu Val Arg Gly Lys Gly Glu 
            20                  25                  30          


Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala 
        35                  40                  45              


Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly 
    50                  55                  60                  


Ser Pro 
65      


<210>  147
<211>  70
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist

<400>  147

His Trp Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Glu Trp Leu Val Arg Gly Lys Gly Glu 
            20                  25                  30          


Gly Gly Gly Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly 
        35                  40                  45              


Arg Leu Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu 
    50                  55                  60                  


Thr Gly Ser Gly Ser Pro 
65                  70  


<210>  148
<211>  74
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist

<400>  148

His Trp Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Glu Trp Leu Val Arg Gly Lys Gly Glu 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Ala Ser Glu Leu Ser Thr 
        35                  40                  45              


Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu His Glu Leu Ala Thr Leu 
    50                  55                  60                  


Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
65                  70                  


<210>  149
<211>  61
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  149

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Lys Glu 
            20                  25                  30          


Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu His Glu Leu 
        35                  40                  45              


Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
    50                  55                  60      


<210>  150
<211>  64
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  150

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Lys Glu 
            20                  25                  30          


Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu 
        35                  40                  45              


His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
    50                  55                  60                  


<210>  151
<211>  70
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  151

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Glu Trp Leu Val Arg Gly Lys Gly Glu 
            20                  25                  30          


Gly Gln Glu Pro Gly Gly Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly 
        35                  40                  45              


Arg Leu Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu 
    50                  55                  60                  


Thr Gly Ser Gly Ser Pro 
65                  70  


<210>  152
<211>  72
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  152

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Ala Trp Leu Val Arg Gly Lys Gly Gly 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala 
        35                  40                  45              


Leu Gly Arg Leu Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg 
    50                  55                  60                  


Thr Glu Thr Gly Ser Gly Ser Pro 
65                  70          


<210>  153
<211>  68
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  153

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Lys Gly 
            20                  25                  30          


Gly Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu 
        35                  40                  45              


Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly 
    50                  55                  60                  


Ser Gly Ser Pro 
65              


<210>  154
<211>  66
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  154

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Lys Gly 
            20                  25                  30          


Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala 
        35                  40                  45              


Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly 
    50                  55                  60                  


Ser Pro 
65      


<210>  155
<211>  66
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  155

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Ala Trp Leu Val Arg Gly Arg Lys Gly 
            20                  25                  30          


Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala 
        35                  40                  45              


Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly 
    50                  55                  60                  


Ser Pro 
65      


<210>  156
<211>  64
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is Imp (imidazole propionyl)

<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  156

Xaa Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Lys Glu 
            20                  25                  30          


Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu 
        35                  40                  45              


His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
    50                  55                  60                  


<210>  157
<211>  64
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  157

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Glu 
            20                  25                  30          


Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu 
        35                  40                  45              


His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
    50                  55                  60                  


<210>  158
<211>  65
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  158

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Ala Trp Leu Val Arg Gly Lys Gly Gly 
            20                  25                  30          


Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu 
        35                  40                  45              


Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser 
    50                  55                  60                  


Pro 
65  


<210>  159
<211>  65
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  159

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Glu Trp Leu Val Arg Gly Lys Gly Gly 
            20                  25                  30          


Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu 
        35                  40                  45              


Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser 
    50                  55                  60                  


Pro 
65  


<210>  160
<211>  66
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  160

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Glu Trp Leu Val Arg Gly Arg Lys Gly 
            20                  25                  30          


Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala 
        35                  40                  45              


Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly 
    50                  55                  60                  


Ser Pro 
65      


<210>  161
<211>  64
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  161

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Ala Trp Leu Val Arg Gly Arg Lys Glu 
            20                  25                  30          


Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu 
        35                  40                  45              


His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
    50                  55                  60                  


<210>  162
<211>  65
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  162

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Gly Gly 
            20                  25                  30          


Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu 
        35                  40                  45              


Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser 
    50                  55                  60                  


Pro 
65  


<210>  163
<211>  68
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  163

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Gly 
            20                  25                  30          


Gly Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu 
        35                  40                  45              


Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly 
    50                  55                  60                  


Ser Gly Ser Pro 
65              


<210>  164
<211>  67
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  164

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Lys 
            20                  25                  30          


Gly Gly Gly Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser 
        35                  40                  45              


Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser 
    50                  55                  60                  


Gly Ser Pro 
65          


<210>  165
<211>  65
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  165

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Glu Trp Leu Val Arg Gly Lys Gly Gly 
            20                  25                  30          


Gly Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu 
        35                  40                  45              


Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser 
    50                  55                  60                  


Pro 
65  


<210>  166
<211>  62
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  166

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Glu Trp Leu Val Arg Gly Lys Ala Ser 
            20                  25                  30          


Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu His Glu 
        35                  40                  45              


Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
    50                  55                  60          


<210>  167
<211>  68
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  167

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Lys Gly 
            20                  25                  30          


Gly Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu 
        35                  40                  45              


Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly 
    50                  55                  60                  


Ser Gly Ser Pro 
65              


<210>  168
<211>  71
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  168

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gln 
            20                  25                  30          


Ala Pro Gly Gln Glu Pro Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu 
        35                  40                  45              


Gly Arg Leu Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr 
    50                  55                  60                  


Glu Thr Gly Ser Gly Ser Pro 
65                  70      


<210>  169
<211>  72
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  169

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Lys Glu Ala Ser Glu Leu Ser Thr Ala Ala 
        35                  40                  45              


Leu Gly Arg Leu Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg 
    50                  55                  60                  


Thr Glu Thr Gly Ser Gly Ser Pro 
65                  70          


<210>  170
<211>  68
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  170

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Glu Trp Leu Val Arg Gly Arg Lys Glu 
            20                  25                  30          


Ala Glu Ala Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu 
        35                  40                  45              


Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly 
    50                  55                  60                  


Ser Gly Ser Pro 
65              


<210>  171
<211>  71
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  171

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gln 
            20                  25                  30          


Glu Pro Lys Gly Gln Ala Pro Ala Ser Arg Leu Ser Thr Glu Ala Leu 
        35                  40                  45              


Gly Arg Leu Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr 
    50                  55                  60                  


Glu Thr Gly Ser Gly Ser Pro 
65                  70      


<210>  172
<211>  69
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist

<400>  172

His Trp Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Glu Trp Leu Val Arg Gly Arg Gly Glu 
            20                  25                  30          


Gly Gly Gly Gly Gly Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg 
        35                  40                  45              


Leu Ser Lys Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr 
    50                  55                  60                  


Gly Ser Gly Ser Pro 
65                  


<210>  173
<211>  69
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist

<400>  173

His Trp Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Glu Trp Leu Val Arg Gly Arg Gly Glu 
            20                  25                  30          


Gly Gly Gly Gly Gly Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg 
        35                  40                  45              


Leu Ser Ala Glu Leu His Glu Leu Lys Thr Leu Pro Arg Thr Glu Thr 
    50                  55                  60                  


Gly Ser Gly Ser Pro 
65                  


<210>  174
<211>  69
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist

<400>  174

His Trp Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Glu Trp Leu Val Arg Gly Lys Gly Glu 
            20                  25                  30          


Gly Gly Gly Gly Gly Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg 
        35                  40                  45              


Leu Ser Lys Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr 
    50                  55                  60                  


Gly Ser Gly Ser Pro 
65                  


<210>  175
<211>  69
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist

<400>  175

His Trp Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Glu Trp Leu Val Arg Gly Lys Gly Glu 
            20                  25                  30          


Gly Gly Gly Gly Gly Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg 
        35                  40                  45              


Leu Ser Ala Glu Leu His Glu Leu Lys Thr Leu Pro Arg Thr Glu Thr 
    50                  55                  60                  


Gly Ser Gly Ser Pro 
65                  


<210>  176
<211>  67
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  176

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Lys Gly 
            20                  25                  30          


Gly Gly Gly Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser 
        35                  40                  45              


Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser 
    50                  55                  60                  


Gly Ser Pro 
65          


<210>  177
<211>  69
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist

<400>  177

His Trp Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Glu Trp Leu Val Arg Gly Arg Gly Glu 
            20                  25                  30          


Gly Gly Gly Gly Gly Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg 
        35                  40                  45              


Leu Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr 
    50                  55                  60                  


Gly Ser Gly Ser Pro 
65                  


<210>  178
<211>  68
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  178

His Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Gly Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu 
        35                  40                  45              


Ser Ala Glu Leu His Lys Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly 
    50                  55                  60                  


Ser Gly Ser Pro 
65              


<210>  179
<211>  68
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  179

His Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Gly Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu 
        35                  40                  45              


Ser Ala Glu Leu His Glu Leu Lys Thr Leu Pro Arg Thr Glu Thr Gly 
    50                  55                  60                  


Ser Gly Ser Pro 
65              


<210>  180
<211>  68
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  180

His Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Gly Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu 
        35                  40                  45              


Ser Ala Glu Leu His Glu Leu Ala Thr Leu Lys Arg Thr Glu Thr Gly 
    50                  55                  60                  


Ser Gly Ser Pro 
65              


<210>  181
<211>  67
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  181

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Gly Gly 
            20                  25                  30          


Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser 
        35                  40                  45              


Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser 
    50                  55                  60                  


Gly Ser Pro 
65          


<210>  182
<211>  67
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  182

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Lys Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser 
        35                  40                  45              


Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser 
    50                  55                  60                  


Gly Ser Pro 
65          


<210>  183
<211>  67
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  183

His Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser 
        35                  40                  45              


Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser 
    50                  55                  60                  


Gly Ser Pro 
65          


<210>  184
<211>  64
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist

<400>  184

His Trp Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Glu Trp Leu Val Arg Gly Lys Gly Glu 
            20                  25                  30          


Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu 
        35                  40                  45              


His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
    50                  55                  60                  


<210>  185
<211>  68
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist

<400>  185

His Trp Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Lys Gly 
            20                  25                  30          


Gly Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu 
        35                  40                  45              


Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly 
    50                  55                  60                  


Ser Gly Ser Pro 
65              


<210>  186
<211>  68
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist

<400>  186

His Trp Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Glu Trp Leu Val Arg Gly Arg Lys Gly 
            20                  25                  30          


Gly Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu 
        35                  40                  45              


Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly 
    50                  55                  60                  


Ser Gly Ser Pro 
65              


<210>  187
<211>  64
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist

<400>  187

His Trp Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Lys Ala Ala Arg Glu Phe Ile Glu Trp Leu Val Arg Gly Arg Gly Glu 
            20                  25                  30          


Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu 
        35                  40                  45              


His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
    50                  55                  60                  


<210>  188
<211>  64
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist

<400>  188

His Trp Glu Gly Thr Phe Thr Ser Asp Lys Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Glu Trp Leu Val Arg Gly Arg Gly Glu 
            20                  25                  30          


Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu 
        35                  40                  45              


His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
    50                  55                  60                  


<210>  189
<211>  68
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  189

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Gly Gly 
            20                  25                  30          


Gly Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu 
        35                  40                  45              


Ser Ala Glu Leu His Lys Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly 
    50                  55                  60                  


Ser Gly Ser Pro 
65              


<210>  190
<211>  68
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  190

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Gly Gly 
            20                  25                  30          


Gly Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu 
        35                  40                  45              


Ser Ala Glu Leu His Glu Leu Lys Thr Leu Pro Arg Thr Glu Thr Gly 
    50                  55                  60                  


Ser Gly Ser Pro 
65              


<210>  191
<211>  68
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  191

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Gly Gly 
            20                  25                  30          


Gly Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu 
        35                  40                  45              


Ser Ala Glu Leu His Glu Leu Ala Thr Leu Lys Arg Thr Glu Thr Gly 
    50                  55                  60                  


Ser Gly Ser Pro 
65              


<210>  192
<211>  68
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  192

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Gly Gly 
            20                  25                  30          


Gly Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu 
        35                  40                  45              


Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly 
    50                  55                  60                  


Lys Gly Ser Pro 
65              


<210>  193
<211>  67
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  193

His Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser 
        35                  40                  45              


Lys Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser 
    50                  55                  60                  


Gly Ser Pro 
65          


<210>  194
<211>  67
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  194

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Lys 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser 
        35                  40                  45              


Lys Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser 
    50                  55                  60                  


Gly Ser Pro 
65          


<210>  195
<211>  67
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  195

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Lys Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser 
        35                  40                  45              


Lys Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser 
    50                  55                  60                  


Gly Ser Pro 
65          


<210>  196
<211>  67
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  196

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser 
        35                  40                  45              


Lys Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser 
    50                  55                  60                  


Gly Ser Pro 
65          


<210>  197
<211>  67
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  197

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Lys Arg Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser 
        35                  40                  45              


Lys Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser 
    50                  55                  60                  


Gly Ser Pro 
65          


<210>  198
<211>  68
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  198

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Lys Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Gly Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu 
        35                  40                  45              


Ser Ala Glu Leu His Lys Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly 
    50                  55                  60                  


Ser Gly Ser Pro 
65              


<210>  199
<211>  68
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  199

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Lys Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Gly Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu 
        35                  40                  45              


Ser Ala Glu Leu His Glu Leu Lys Thr Leu Pro Arg Thr Glu Thr Gly 
    50                  55                  60                  


Ser Gly Ser Pro 
65              


<210>  200
<211>  68
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  200

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Lys Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Gly Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu 
        35                  40                  45              


Ser Ala Glu Leu His Glu Leu Ala Thr Leu Lys Arg Thr Glu Thr Gly 
    50                  55                  60                  


Ser Gly Ser Pro 
65              


<210>  201
<211>  68
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  201

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Lys Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Gly Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu 
        35                  40                  45              


Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly 
    50                  55                  60                  


Lys Gly Ser Pro 
65              


<210>  202
<211>  64
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist

<400>  202

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Lys Ala Ala Arg Glu Phe Ile Glu Trp Leu Val Arg Gly Arg Gly Glu 
            20                  25                  30          


Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu 
        35                  40                  45              


His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
    50                  55                  60                  


<210>  203
<211>  64
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  203

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Lys Ala Ala Arg Glu Phe Ile Glu Trp Leu Val Arg Gly Arg Gly Glu 
            20                  25                  30          


Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu 
        35                  40                  45              


His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
    50                  55                  60                  


<210>  204
<211>  64
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist

<400>  204

His Ala Glu Gly Thr Phe Thr Ser Lys Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Glu Trp Leu Val Arg Gly Arg Gly Glu 
            20                  25                  30          


Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu 
        35                  40                  45              


His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
    50                  55                  60                  


<210>  205
<211>  64
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  205

His Xaa Glu Gly Thr Phe Thr Ser Lys Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Glu Trp Leu Val Arg Gly Arg Gly Glu 
            20                  25                  30          


Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu 
        35                  40                  45              


His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
    50                  55                  60                  


<210>  206
<211>  64
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist

<400>  206

His Ala Glu Gly Thr Phe Thr Ser Asp Lys Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Glu Trp Leu Val Arg Gly Arg Gly Glu 
            20                  25                  30          


Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu 
        35                  40                  45              


His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
    50                  55                  60                  


<210>  207
<211>  64
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist

<400>  207

His Trp Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Glu Trp Leu Val Arg Gly Arg Gly Glu 
            20                  25                  30          


Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu 
        35                  40                  45              


His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
    50                  55                  60                  


<210>  208
<211>  64
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  208

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Glu Trp Leu Val Arg Gly Arg Gly Glu 
            20                  25                  30          


Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu 
        35                  40                  45              


His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
    50                  55                  60                  


<210>  209
<211>  64
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist

<400>  209

His Trp Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Glu Trp Leu Val Arg Gly Arg Gly Glu 
            20                  25                  30          


Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu 
        35                  40                  45              


His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
    50                  55                  60                  


<210>  210
<211>  64
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  210

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Glu Trp Leu Val Arg Gly Arg Lys Glu 
            20                  25                  30          


Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu 
        35                  40                  45              


His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
    50                  55                  60                  


<210>  211
<211>  64
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  211

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Glu Trp Leu Val Arg Gly Arg Gly Glu 
            20                  25                  30          


Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu 
        35                  40                  45              


His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
    50                  55                  60                  


<210>  212
<211>  64
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  212

His Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Glu Trp Leu Val Arg Gly Arg Gly Glu 
            20                  25                  30          


Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu 
        35                  40                  45              


His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
    50                  55                  60                  


<210>  213
<211>  64
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist

<400>  213

His Ala Glu Gly Thr Phe Thr Ser Asp Lys Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Lys Ala Ala Arg Glu Phe Ile Glu Trp Leu Val Arg Gly Arg Gly Glu 
            20                  25                  30          


Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu 
        35                  40                  45              


His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
    50                  55                  60                  


<210>  214
<211>  66
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist

<400>  214

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Val Arg Glu Phe Ile Ala Lys Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala 
        35                  40                  45              


Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly 
    50                  55                  60                  


Ser Pro 
65      


<210>  215
<211>  66
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  215

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Val Arg Glu Phe Ile Ala Lys Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala 
        35                  40                  45              


Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly 
    50                  55                  60                  


Ser Pro 
65      


<210>  216
<211>  68
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  216

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Glu Trp Leu Val Arg Gly Arg Lys Gly 
            20                  25                  30          


Gly Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu 
        35                  40                  45              


Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly 
    50                  55                  60                  


Ser Gly Ser Pro 
65              


<210>  217
<211>  69
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  217

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Pro Lys 
            20                  25                  30          


Gly Gly Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg 
        35                  40                  45              


Leu Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr 
    50                  55                  60                  


Gly Ser Gly Ser Pro 
65                  


<210>  218
<211>  68
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  218

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Gly Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu 
        35                  40                  45              


Ser Ala Glu Leu His Lys Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly 
    50                  55                  60                  


Ser Gly Ser Pro 
65              


<210>  219
<211>  68
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  219

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Arg Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Glu Trp Leu Val Arg Gly Arg Lys Gly 
            20                  25                  30          


Gly Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu 
        35                  40                  45              


Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly 
    50                  55                  60                  


Ser Gly Ser Pro 
65              


<210>  220
<211>  68
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  220

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Gly Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu 
        35                  40                  45              


Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly 
    50                  55                  60                  


Ser Gly Ser Pro 
65              


<210>  221
<211>  68
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  221

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Gly Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu 
        35                  40                  45              


Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly 
    50                  55                  60                  


Ser Gly Ser Pro 
65              


<210>  222
<211>  68
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  222

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Lys Gly 
            20                  25                  30          


Gly Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu 
        35                  40                  45              


Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly 
    50                  55                  60                  


Ser Gly Ser Pro 
65              


<210>  223
<211>  64
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist

<400>  223

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Glu 
            20                  25                  30          


Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu 
        35                  40                  45              


His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
    50                  55                  60                  


<210>  224
<211>  68
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  224

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Gly Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu 
        35                  40                  45              


Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly 
    50                  55                  60                  


Ser Gly Ser Pro 
65              


<210>  225
<211>  69
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  225

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Ala Trp Leu Val Arg Gly Arg Gln Glu 
            20                  25                  30          


Gly Gly Gly Gly Gly Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg 
        35                  40                  45              


Leu Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr 
    50                  55                  60                  


Gly Ser Gly Ser Pro 
65                  


<210>  226
<211>  69
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  226

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Glu Trp Leu Val Arg Gly Arg Gly Glu 
            20                  25                  30          


Gly Gly Gly Gly Gly Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg 
        35                  40                  45              


Leu Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr 
    50                  55                  60                  


Gly Ser Gly Ser Pro 
65                  


<210>  227
<211>  64
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  227

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Glu Trp Leu Val Arg Gly Arg Gly Glu 
            20                  25                  30          


Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu 
        35                  40                  45              


His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
    50                  55                  60                  


<210>  228
<211>  64
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  228

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Ala Trp Leu Val Arg Gly Arg Gln Glu 
            20                  25                  30          


Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu 
        35                  40                  45              


His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
    50                  55                  60                  


<210>  229
<211>  62
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  229

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Ala Trp Leu Val Arg Gly Gly Ala Ser 
            20                  25                  30          


Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu His Glu 
        35                  40                  45              


Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
    50                  55                  60          


<210>  230
<211>  61
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  230

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Glu Trp Leu Val Arg Gly Ala Ser Glu 
            20                  25                  30          


Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu His Glu Leu 
        35                  40                  45              


Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
    50                  55                  60      


<210>  231
<211>  64
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  231

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Glu Trp Leu Val Arg Gly Ala Ala Glu 
            20                  25                  30          


Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu 
        35                  40                  45              


His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
    50                  55                  60                  


<210>  232
<211>  64
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  232

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Glu Trp Leu Val Arg Gly Ala Ala Glu 
            20                  25                  30          


Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu 
        35                  40                  45              


His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
    50                  55                  60                  


<210>  233
<211>  64
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  233

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Glu 
            20                  25                  30          


Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu Leu 
        35                  40                  45              


His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser Pro 
    50                  55                  60                  


<210>  234
<211>  66
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  234

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Ala Trp Leu Val Arg Gly Arg Lys Gly 
            20                  25                  30          


Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala 
        35                  40                  45              


Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly 
    50                  55                  60                  


Ser Pro 
65      


<210>  235
<211>  65
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  235

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Glu Trp Leu Val Arg Gly Arg Gln Glu 
            20                  25                  30          


Ala Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu 
        35                  40                  45              


Leu His Gln Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser 
    50                  55                  60                  


Pro 
65  


<210>  236
<211>  72
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1-amylin receptor co-agonist


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  236

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Lys Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala 
        35                  40                  45              


Leu Gly Arg Leu Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg 
    50                  55                  60                  


Thr Glu Thr Gly Ser Gly Ser Pro 
65                  70          


<210>  237
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  237

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  238
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist peptide (Z1)


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa can be His (H) or Imp

<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa can be Aib, Ala (A), Gly (G) or Trp (W)

<220>
<221>  Xaa
<222>  (9)..(9)
<223>  Xaa can be Cys (C), Asp (D) or Lys (K)

<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa can be Cys (C), Lys (K) or Val (V)

<220>
<221>  Xaa
<222>  (12)..(12)
<223>  Xaa can be Cys (C), Lys (K), Arg (R) or Ser (S)

<220>
<221>  Xaa
<222>  (16)..(16)
<223>  Xaa can be Cys (C), Glu (E), Gly (G) or Lys (K)

<220>
<221>  Xaa
<222>  (17)..(17)
<223>  Xaa can be Cys (C), Gln (Q) or Lys (K)

<220>
<221>  Xaa
<222>  (19)..(19)
<223>  Xaa can be Ala (A) or Val (V)

<220>
<221>  Xaa
<222>  (20)..(20)
<223>  Xaa can be Cys (C), Lys (K) or Arg (R)

<220>
<221>  Xaa
<222>  (21)..(21)
<223>  Xaa can be Cys (C), Glu (E) or Lys (K)

<220>
<221>  Xaa
<222>  (22)..(22)
<223>  Xaa can be Phe (F), Trp (W) or Tyr (Y)

<220>
<221>  Xaa
<222>  (23)..(23)
<223>  Xaa can be Ile (I), Leu (L) or Val (V)

<220>
<221>  Xaa
<222>  (24)..(24)
<223>  Xaa can be Ala (A), Cys (C), Glu (E) or Leu (L)

<220>
<221>  Xaa
<222>  (25)..(25)
<223>  Xaa can be Cys (C), Lys (K) or Trp (W)

<220>
<221>  Xaa
<222>  (28)..(28)
<223>  Xaa can be Cys (C), Lys (K) or Arg (R)

<220>
<221>  Xaa
<222>  (29)..(29)
<223>  Xaa can be Cys (C), Lys (K) or Gly (G)

<220>
<221>  Xaa
<222>  (30)..(30)
<223>  Xaa can be Ala (A), Cys (C), Gly (G), Lys (K), Arg (R) or absent

<220>
<221>  Xaa
<222>  (31)..(31)
<223>  Xaa can be Ala (A), Cys (C), Lys (K), Gly (G), Gln (Q) or absent

<400>  238

Xaa Xaa Glu Gly Thr Phe Thr Ser Xaa Xaa Ser Xaa Tyr Leu Glu Xaa 
1               5                   10                  15      


Xaa Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Val Xaa Xaa Xaa Xaa 
            20                  25                  30      


<210>  239
<211>  30
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Optional peptide linker (Z2)


<220>
<221>  Xaa
<222>  (1)..(30)
<223>  Xaa is absent or is any canonical amino acid

<400>  239

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30  


<210>  240
<211>  32
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Amylin receptor agonist peptide (Z3)


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa can be Ala (A), Cys (C), Lys (K) or absent

<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa can be Cys (C), Lys (K) or Ser (S)

<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa can be Cys (C), Glu (E), Lys (K) or Arg (R)

<220>
<221>  Xaa
<222>  (7)..(7)
<223>  Xaa can be Ala (A), Cys (C), Glu (E) or Lys (K)

<220>
<221>  Xaa
<222>  (14)..(14)
<223>  Xaa can be Ala (A), Cys (C) or Lys (K)

<220>
<221>  Xaa
<222>  (18)..(18)
<223>  Xaa can be Cys (C), Glu (E), Lys (K) or Gln (Q)

<220>
<221>  Xaa
<222>  (20)..(20)
<223>  Xaa can be Ala (A), Cys (C) or Lys (K)

<220>
<221>  Xaa
<222>  (23)..(23)
<223>  Xaa can be Cys (C),  Lys (K) or Pro (P)

<220>
<221>  Xaa
<222>  (29)..(29)
<223>  Xaa can be Cys (C), Ser (S) or Lys (K)

<220>
<221>  Xaa
<222>  (32)..(32)
<223>  Xaa can be Pro (P) or Tyr (Y)

<400>  240

Xaa Xaa Xaa Leu Ser Thr Xaa Ala Leu Gly Arg Leu Ser Xaa Glu Leu 
1               5                   10                  15      


His Xaa Leu Xaa Thr Leu Xaa Arg Thr Glu Thr Gly Xaa Gly Ser Xaa 
            20                  25                  30          


<210>  241
<211>  66
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Peptide backbone in comparator compound


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  241

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Ile Phe Ala Trp Leu Val Arg Gly Arg Lys Gly 
            20                  25                  30          


Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala 
        35                  40                  45              


Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly 
    50                  55                  60                  


Ser Pro 
65      


<210>  242
<211>  66
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Peptide backbone in comparator compound


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  242

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Lys Gly 
            20                  25                  30          


Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Pro Ser Ala 
        35                  40                  45              


Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly 
    50                  55                  60                  


Ser Pro 
65      


<210>  243
<211>  75
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Peptide backbone in comparator compound


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  243

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Gln Glu Pro Gly Gln Glu Pro Cys Asn Thr Ala Thr Cys Ala Thr Gln 
        35                  40                  45              


Arg Leu Ala Glu Phe Leu Arg His Ser Ser Asn Asn Phe Gly Pro Ile 
    50                  55                  60                  


Leu Pro Pro Thr Asn Val Gly Ser Asn Thr Pro 
65                  70                  75  


<210>  244
<211>  76
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Peptide backbone in comparator compound


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  244

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Gln Glu Pro Gly Gln Glu Pro Lys Cys Asn Thr Ala Thr Cys Ala Thr 
        35                  40                  45              


Gln Arg Leu Ala Glu Phe Leu Arg His Ser Ser Asn Asn Phe Gly Pro 
    50                  55                  60                  


Ile Leu Pro Pro Thr Asn Val Gly Ser Asn Thr Pro 
65                  70                  75      


<210>  245
<211>  76
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Peptide backbone in comparator compound


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  245

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Gln Glu Pro Gly Gln Glu Pro Lys Cys Asn Thr Ala Thr Cys Ala Thr 
        35                  40                  45              


Gln Arg Leu Ala Asp Phe Leu Arg His Ser Ser Pro Asn Phe Gly Ala 
    50                  55                  60                  


Ile Pro Ser Ser Thr Asn Val Gly Ser Arg Thr Tyr 
65                  70                  75      


<210>  246
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Peptide backbone in semaglutide


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  246

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  247
<211>  37
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Peptide backbone in pramlintide

<400>  247

Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val His Ser Ser Asn Asn Phe Gly Pro Ile Leu Pro Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  248
<211>  37
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Peptide backbone in cagrilintide

<400>  248

Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Glu Phe Leu 
1               5                   10                  15      


Arg His Ser Ser Asn Asn Phe Gly Pro Ile Leu Pro Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Pro 
        35          


<210>  249
<211>  32
<212>  PRT
<213>  Salmo salar

<400>  249

Cys Ser Asn Leu Ser Thr Cys Val Leu Gly Lys Leu Ser Gln Glu Leu 
1               5                   10                  15      


His Lys Leu Gln Thr Tyr Pro Arg Thr Asn Thr Gly Ser Gly Thr Pro 
            20                  25                  30          


<210>  250
<211>  33
<212>  PRT
<213>  Artificial

<220>
<223>  Compound 1806

<400>  250

Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu 
1               5                   10                  15      


Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Ser Gly Ser 
            20                  25                  30          


Pro 
    


<210>  251
<211>  73
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Peptide backbone in comparator compound 0671


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  251

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Lys Gly 
            20                  25                  30          


Gly Gly Gly Glu Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu 
        35                  40                  45              


Ala Asn Phe Leu Val His Ser Ser Asn Asn Phe Gly Pro Ile Leu Pro 
    50                  55                  60                  


Pro Thr Asn Val Gly Ser Asn Thr Tyr 
65                  70              


<210>  252
<211>  73
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Peptide backbone in comparator compound 0672


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  252

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Lys Gly 
            20                  25                  30          


Gly Gly Gly Glu Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu 
        35                  40                  45              


Ala Glu Phe Leu Arg His Ser Ser Asn Asn Phe Gly Pro Ile Leu Pro 
    50                  55                  60                  


Pro Thr Asn Val Gly Ser Asn Thr Pro 
65                  70              


<210>  253
<211>  68
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Peptide backbone in comparator compound 0167


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  253

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Ile Phe Ala Trp Leu Val Arg Gly Arg Lys Gly 
            20                  25                  30          


Gly Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu 
        35                  40                  45              


Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly 
    50                  55                  60                  


Ser Gly Ser Pro 
65              


<210>  254
<211>  68
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Peptide backbone in comparator compound 0192


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyryl)

<400>  254

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Lys Gly 
            20                  25                  30          


Gly Gly Gly Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Pro 
        35                  40                  45              


Ser Ala Glu Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly 
    50                  55                  60                  


Ser Gly Ser Pro 
65              


<210>  255
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 receptor agonist peptide (Z1)


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa can be His (H) or Imp

<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa can be Aib, Ala (A), Gly (G) or Trp (W)

<220>
<221>  Xaa
<222>  (9)..(9)
<223>  Xaa can be Asp (D) or Lys (K)

<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa can be Lys (K) or Val (V)

<220>
<221>  Xaa
<222>  (12)..(12)
<223>  Xaa can be Lys (K), Arg (R) or Ser (S)

<220>
<221>  Xaa
<222>  (16)..(16)
<223>  Xaa can be Glu (E), Gly (G) or Lys (K)

<220>
<221>  Xaa
<222>  (17)..(17)
<223>  Xaa can be Gln (Q) or Lys (K)

<220>
<221>  Xaa
<222>  (19)..(19)
<223>  Xaa can be Ala (A) or Val (V)

<220>
<221>  Xaa
<222>  (20)..(20)
<223>  Xaa can be Lys (K) or Arg (R)

<220>
<221>  Xaa
<222>  (21)..(21)
<223>  Xaa can be Glu (E) or Lys (K)

<220>
<221>  Xaa
<222>  (22)..(22)
<223>  Xaa can be Phe (F), Trp (W) or Tyr (Y)

<220>
<221>  Xaa
<222>  (23)..(23)
<223>  Xaa can be Ile (I), Leu (L) or Val (V)

<220>
<221>  Xaa
<222>  (24)..(24)
<223>  Xaa can be Ala (A), Glu (E) or Leu (L)

<220>
<221>  Xaa
<222>  (25)..(25)
<223>  Xaa can be Lys (K) or Trp (W)

<220>
<221>  Xaa
<222>  (28)..(28)
<223>  Xaa can be Lys (K) or Arg (R)

<220>
<221>  Xaa
<222>  (29)..(29)
<223>  Xaa can be Lys (K) or Gly (G)

<220>
<221>  Xaa
<222>  (30)..(30)
<223>  Xaa can be Ala (A), Gly (G), Lys (K), Arg (R) or absent

<220>
<221>  Xaa
<222>  (31)..(31)
<223>  Xaa can be Ala (A), Lys (K), Gly (G), Gln (Q) or absent

<400>  255

Xaa Xaa Glu Gly Thr Phe Thr Ser Xaa Xaa Ser Xaa Tyr Leu Glu Xaa 
1               5                   10                  15      


Xaa Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Val Xaa Xaa Xaa Xaa 
            20                  25                  30      


<210>  256
<211>  32
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Amylin receptor agonist peptide (Z3)


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa can be Ala (A), Lys (K) or absent

<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa can be Lys (K) or Ser (S)

<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa can be Glu (E), Lys (K) or Arg (R)

<220>
<221>  Xaa
<222>  (7)..(7)
<223>  Xaa can be Ala (A), Glu (E) or Lys (K)

<220>
<221>  Xaa
<222>  (14)..(14)
<223>  Xaa can be Ala (A) or Lys (K)

<220>
<221>  Xaa
<222>  (18)..(18)
<223>  Xaa can be Glu (E), Lys (K) or Gln (Q)

<220>
<221>  Xaa
<222>  (20)..(20)
<223>  Xaa can be Ala (A) or Lys (K)

<220>
<221>  Xaa
<222>  (23)..(23)
<223>  Xaa can be Lys (K) or Pro (P)

<220>
<221>  Xaa
<222>  (29)..(29)
<223>  Xaa can be Ser (S) or Lys (K)

<220>
<221>  Xaa
<222>  (32)..(32)
<223>  Xaa can be Pro (P) or Tyr (Y)

<400>  256

Xaa Xaa Xaa Leu Ser Thr Xaa Ala Leu Gly Arg Leu Ser Xaa Glu Leu 
1               5                   10                  15      


His Xaa Leu Xaa Thr Leu Xaa Arg Thr Glu Thr Gly Xaa Gly Ser Xaa 
            20                  25                  30          


