                         SEQUENCE LISTING

<110>  Elasmogen Ltd
 
<120>  Fast-track humanisation

<130>  P138078GB

<160>  101   

<170>  PatentIn version 3.5

<210>  1
<211>  28
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence - humanised FW1


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Where X is - or D

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Where X is A or I or T

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Where X is S or Q or R

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Where X is V or M

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Where X is N or T or D

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Where X is L or V

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Where X is T or R

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Where X is D or G

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Where X is T or A or S

<400>  1

Xaa Xaa Xaa Xaa Xaa Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Val Xaa Xaa Xaa Xaa 
            20                  25              


<210>  2
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence - FW2


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Where X is S or Y

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Where X is F or Y

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Where X is R or Q

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Where X is K or Q

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Where X is N or K

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Where X is P or S

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Where X is T or S

<400>  2

Thr Xaa Trp Xaa Xaa Xaa Xaa Xaa Gly Xaa 
1               5                   10  


<210>  3
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence - FW3a


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Where X is Y or F

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Where X is V or S

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Where X is E or G

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Where X is S or T

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Where X is V or G or I

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Where X is N or S

<400>  3

Gly Arg Xaa Xaa Xaa Xaa Xaa Xaa 
1               5               


<210>  4
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence - FW3b


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Where X is S or T

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Where X is R or T

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Where X is K or S or N

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Where X is D or S

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Where X is T or Q

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Where X is V or P

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Where X is A or E

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Where X is S or F

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Where X is A or G

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Where X is Y or R or I

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Where X is K or R or A

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Where X is A or S or L

<400>  4

Phe Xaa Leu Xaa Ile Xaa Xaa Leu Xaa Xaa Xaa Asp Xaa Xaa Thr Tyr 
1               5                   10                  15      


Xaa Cys Xaa Xaa 
            20  


<210>  5
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence - FW4


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Where X is D or Y or F

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Where X is A or G or Q

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Where X is K or V

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Where X is V or L

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Where X is E or T

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Where X is I or V

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Where X is K or N

<400>  5

Xaa Gly Xaa Gly Thr Xaa Xaa Xaa Xaa Xaa 
1               5                   10  


<210>  6
<211>  27
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence - V1 to V5 FW1


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Where X is A or T

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Where X is S or R

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Where X is N or D

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Where X is L or V

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Where X is D or G

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Where X is T or A

<400>  6

Xaa Xaa Val Xaa Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Xaa Thr Xaa Xaa 
            20                  25          


<210>  7
<211>  28
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence - V6 FW1


<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Where X is L or V

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Where X is D or G

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Where X is T or A

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Val Xaa Thr Xaa Xaa 
            20                  25              


<210>  8
<211>  27
<212>  PRT
<213>  artificial sequence

<220>
<223>  soloMER D1v2 / C4v1 QuadX - FW1

<400>  8

Ala Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Arg Asp Ser 
            20                  25          


<210>  9
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence - V1 to V3 FW2


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Where X is S or Y

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Where X is F or Y

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Where X is T or S

<400>  9

Thr Xaa Trp Xaa Arg Lys Asn Pro Gly Xaa 
1               5                   10  


<210>  10
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence - V4 to V6 FW2


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Where X is S or Y

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Where X is Y or F

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Where X is T or S

<400>  10

Thr Xaa Trp Xaa Gln Gln Lys Pro Gly Xaa 
1               5                   10  


<210>  11
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  soloMER D1v2 / C4v1 QuadX - FW2

<400>  11

Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser 
1               5                   10  


<210>  12
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  FW3a V1, V2, V3

<400>  12

Gly Arg Tyr Val Glu Ser Val Asn 
1               5               


<210>  13
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  FW3a V4, V5, V6

<400>  13

Gly Arg Phe Ser Gly Ser Gly Ser 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  soloMER D1v2 FW3a

<400>  14

Gly Arg Tyr Val Glu Thr Val Asn 
1               5               


<210>  15
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  soloMER C4v1 FW3a

<400>  15

Gly Arg Tyr Val Glu Thr Ile Asn 
1               5               


<210>  16
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence - FW3b


<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Where X is Y or I

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Where X is K or R

<400>  16

Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr Tyr 
1               5                   10                  15      


Xaa Cys Xaa Ala 
            20  


<210>  17
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence - FW3b


<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Where X is Y or I

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Where X is K or R

<400>  17

Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
1               5                   10                  15      


Xaa Cys Xaa Ala 
            20  


<210>  18
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  soloMER D1v2 FW3b

<400>  18

Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
1               5                   10                  15      


Tyr Cys Ala Ser 
            20  


<210>  19
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  soloMER C4v1 Fw3b

<400>  19

Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr Tyr 
1               5                   10                  15      


Arg Cys Lys Leu 
            20  


<210>  20
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence - FW4


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Where X is D or Y or F

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Where X is A or G or Q

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Where X is V or L

<400>  20

Xaa Gly Xaa Gly Thr Lys Xaa Glu Ile Lys 
1               5                   10  


<210>  21
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  soloMER D1v2 / C4v1 QuadX - FW4

<400>  21

Tyr Gly Gly Gly Thr Val Val Thr Val Asn 
1               5                   10  


<210>  22
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence - FW2


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Where X is S or Y

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Where X is F or Y

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Where X is R or Q

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Where X is K or Q

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Where X is N or K

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Where X is P or S

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Where X is T or S

<400>  22

Thr Xaa Trp Xaa Xaa Xaa Xaa Xaa Gly Xaa 
1               5                   10  


<210>  23
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence - FW3a


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Where X is Y or F

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Where X is V or S

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Where X is E or G

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Where X is S or T

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Where X is V or G or I

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Where X is N or S

<400>  23

Gly Arg Xaa Xaa Xaa Xaa Xaa Xaa 
1               5               


<210>  24
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence - FW3b


<220>
<221>  msic_feature
<222>  (2)..(2)
<223>  Where X is S or T

<220>
<221>  msic_feature
<222>  (4)..(4)
<223>  Where X is R or T

<220>
<221>  msic_feature
<222>  (6)..(6)
<223>  Where X is K or S or N

<220>
<221>  msic_feature
<222>  (7)..(7)
<223>  Where X is D or S

<220>
<221>  msic_feature
<222>  (9)..(9)
<223>  Where X is T or Q

<220>
<221>  msic_feature
<222>  (10)..(10)
<223>  Where X is V or P

<220>
<221>  msic_feature
<222>  (11)..(11)
<223>  Where X is A or E

<220>
<221>  msic_feature
<222>  (13)..(13)
<223>  Where X is S or F

<220>
<221>  msic_feature
<222>  (14)..(14)
<223>  Where X is A or G

<220>
<221>  msic_feature
<222>  (17)..(17)
<223>  Where X is Y or R or I

<220>
<221>  msic_feature
<222>  (19)..(19)
<223>  Where X is K or R or A

<220>
<221>  msic_feature
<222>  (20)..(20)
<223>  Where X is A or S or L

<400>  24

Phe Xaa Leu Xaa Ile Xaa Xaa Leu Xaa Xaa Xaa Asp Xaa Xaa Thr Tyr 
1               5                   10                  15      


Xaa Cys Xaa Xaa 
            20  


<210>  25
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence - FW4


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Where X is D or Y

<400>  25

Xaa Gly Ala Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  26
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence - CDR1


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Where X is Y or T or R or I or K or N or S

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Where X is C or Y

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Where X is P or S or A or G

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Where X is W or L

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Where X is H or S or Y

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Where X is N or R or G or S

<400>  26

Xaa Xaa Xaa Xaa Xaa Xaa 
1               5       


<210>  27
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence - HV2


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Where X is S or T or P

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Where X is N or D

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Where X is Q or W

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Where X is I or M

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Where X is G or S

<400>  27

Xaa Xaa Xaa Glu Arg Xaa Ser Ile Xaa 
1               5                   


<210>  28
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence - HV4


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Where X is G or R

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Where X is T or P or S

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Where X is K or M

<400>  28

Lys Xaa Xaa Xaa Ser 
1               5   


<210>  29
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 of the first VNAR domain

<400>  29

His Cys Ala Thr Ser Ser 
1               5       


<210>  30
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 of the second VNAR domain

<400>  30

Asn Cys Gly Leu Ser Ser 
1               5       


<210>  31
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 of the VNAR domain

<400>  31

Asn Cys Ala Leu Ser Ser 
1               5       


<210>  32
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  HV2 of the first and second VNAR domain

<400>  32

Thr Asn Glu Glu Ser Ile Ser Lys Gly 
1               5                   


<210>  33
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  HV4 of the first VNAR domain

<400>  33

Ser Gly Ser Lys Ser 
1               5   


<210>  34
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  HV4 of the second VNAR domain

<400>  34

Glu Gly Ser Lys Ser 
1               5   


<210>  35
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 of the first VNAR domain

<400>  35

Glu Cys Gln Tyr Gly Leu Ala Glu Tyr Asp Val 
1               5                   10      


<210>  36
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 of the second VNAR domain

<400>  36

Ser Trp Trp Thr Gln Asn Trp Arg Cys Ser Asn Ser Asp Val 
1               5                   10                  


<210>  37
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 of a further VNAR domain

<400>  37

Tyr Ile Pro Cys Ile Asp Glu Leu Val Tyr Met Ile Ser Gly Gly Thr 
1               5                   10                  15      


Ser Gly Pro Ile His Asp Val 
            20              


<210>  38
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  soloMER D1 QuadX v2

<400>  38

Ala Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Arg Asp Ser His Cys Ala Thr Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Ala Ser Glu Cys Gln Tyr Gly Leu Ala Glu Tyr Asp Val 
                85                  90                  95      


Tyr Gly Gly Gly Thr Val Val Thr Val Asn 
            100                 105     


<210>  39
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  soloMER DC4 QuadX v2

<400>  39

Ala Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Arg Asp Ser Asn Cys Gly Leu Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Ile Asn Glu Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Lys Leu Ser Trp Trp Thr Gln Asn Trp Arg Cys Ser Asn 
                85                  90                  95      


Ser Asp Val Tyr Gly Gly Gly Thr Val Val Thr Val Asn 
            100                 105                 


<210>  40
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  DPK-9

<400>  40

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Asn 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  41
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer D3_FOR_NCoI

<400>  41
agccggccat ggccgcttc                                                    19


<210>  42
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer D3_REV_NotI

<400>  42
atgtgcggcc gcccctgagg cctg                                              24


<210>  43
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  D1

<400>  43

Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Ser His Cys Ala Thr Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Ala Ser Glu Cys Gln Tyr Gly Leu Ala Glu Tyr Asp Val 
                85                  90                  95      


Tyr Gly Gly Gly Thr Val Val Thr Val Asn 
            100                 105     


<210>  44
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  D1-V1

<400>  44

Ala Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Arg Asp Ser His Cys Ala Thr Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Ala Ser Glu Cys Gln Tyr Gly Leu Ala Glu Tyr Asp Val 
                85                  90                  95      


Tyr Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  45
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  D1-V2

<400>  45

Ala Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Arg Asp Ser His Cys Ala Thr Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Ala Ser Glu Cys Gln Tyr Gly Leu Ala Glu Tyr Asp Val 
                85                  90                  95      


Tyr Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  46
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  D1-V3

<400>  46

Ala Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Arg Asp Ser His Cys Ala Thr Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Pro Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Phe Ser Gly Ser Gly Ser Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Ala Ser Glu Cys Gln Tyr Gly Leu Ala Glu Tyr Asp Val 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  47
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  D1-V4

<400>  47

Ala Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Arg Asp Ser His Cys Ala Thr Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Pro Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Phe Ser Gly Ser Gly Ser Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Ala Ser Glu Cys Gln Tyr Gly Leu Ala Glu Tyr Asp Val 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  48
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  D1-V5

<400>  48

Ala Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Arg Asp Ser His Cys Ala Thr Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Phe Ser Gly Ser Gly Ser Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Ala Ser Glu Cys Gln Tyr Gly Leu Ala Glu Tyr Asp Val 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  49
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  D1-V6

<400>  49

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Val Leu Arg Asp Ser His Cys Ala Thr 
            20                  25                  30          


Ser Ser Thr Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Thr Asn Glu Glu 
        35                  40                  45              


Ser Ile Ser Lys Gly Gly Arg Phe Ser Gly Ser Gly Ser Ser Gly Ser 
    50                  55                  60                  


Lys Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
65                  70                  75                  80  


Thr Tyr Tyr Cys Ala Ser Glu Cys Gln Tyr Gly Leu Ala Glu Tyr Asp 
                85                  90                  95      


Val Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  50
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  C4

<400>  50

Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Ser Asn Cys Gly Leu Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Ile Asn Glu Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Lys Leu Ser Trp Trp Thr Gln Asn Trp Arg Cys Ser Asn 
                85                  90                  95      


Ser Asp Val Tyr Gly Gly Gly Thr Val Val Thr Val Asn 
            100                 105                 


<210>  51
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  C4-V1

<400>  51

Ala Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Arg Asp Ser Asn Cys Gly Leu Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Ile Asn Glu Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Lys Leu Ser Trp Trp Thr Gln Asn Trp Arg Cys Ser Asn 
                85                  90                  95      


Ser Asp Val Tyr Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  52
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  C4-V2

<400>  52

Ala Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Arg Asp Ser Asn Cys Gly Leu Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Ile Asn Glu Gly Ser Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Leu Ser Trp Trp Thr Gln Asn Trp Arg Cys Ser Asn 
                85                  90                  95      


Ser Asp Val Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  53
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  C4-V3

<400>  53

Ala Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Arg Asp Ser Asn Cys Gly Leu Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Ile Asn Glu Gly Ser Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Leu Ser Trp Trp Thr Gln Asn Trp Arg Cys Ser Asn 
                85                  90                  95      


Ser Asp Val Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  54
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  C4-V4

<400>  54

Ala Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Arg Asp Ser Asn Cys Gly Leu Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Phe Ser Gly Ser Gly Ser Glu Gly Ser Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Leu Ser Trp Trp Thr Gln Asn Trp Arg Cys Ser Asn 
                85                  90                  95      


Ser Asp Val Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  55
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  C4-V5

<400>  55

Ala Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Arg Asp Ser Asn Cys Gly Leu Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Phe Ser Gly Ser Gly Ser Glu Gly Ser Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Leu Ser Trp Trp Thr Gln Asn Trp Arg Cys Ser Asn 
                85                  90                  95      


Ser Asp Val Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  56
<211>  110
<212>  PRT
<213>  artificial sequence

<220>
<223>  C4-V6

<400>  56

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Val Leu Arg Asp Ser Asn Cys Gly Leu 
            20                  25                  30          


Ser Ser Thr Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Thr Asn Glu Glu 
        35                  40                  45              


Ser Ile Ser Lys Gly Gly Arg Phe Ser Gly Ser Gly Ser Glu Gly Ser 
    50                  55                  60                  


Lys Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
65                  70                  75                  80  


Thr Tyr Tyr Cys Lys Leu Ser Trp Trp Thr Gln Asn Trp Arg Cys Ser 
                85                  90                  95      


Asn Ser Asp Val Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  57
<211>  140
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus

<400>  57

Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Ser His Cys Ala Thr Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Ala Ser Glu Cys Gln Tyr Gly Leu Ala Glu Tyr Asp Val 
                85                  90                  95      


Tyr Gly Gly Gly Thr Val Val Thr Val Asn Gly Ser Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
        115                 120                 125             


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    130                 135                 140 


<210>  58
<211>  484
<212>  PRT
<213>  artificial sequence

<220>
<223>  soloMER D1-Fc-C4 Quad-X (NAR FW1)

<400>  58

Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Ser His Cys Ala Thr Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Ala Ser Glu Cys Gln Tyr Gly Leu Ala Glu Tyr Asp Val 
                85                  90                  95      


Tyr Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Ser Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
        115                 120                 125             


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
    130                 135                 140                 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
145                 150                 155                 160 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                165                 170                 175     


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            180                 185                 190         


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        195                 200                 205             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    210                 215                 220                 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
225                 230                 235                 240 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                245                 250                 255     


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            260                 265                 270         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        275                 280                 285             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    290                 295                 300                 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
305                 310                 315                 320 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                325                 330                 335     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly 
            340                 345                 350         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Gly Ser Ala Arg Val Asp Gln Thr Pro Gln Thr 
    370                 375                 380                 


Ile Thr Lys Glu Thr Gly Glu Ser Leu Thr Ile Asn Cys Val Leu Arg 
385                 390                 395                 400 


Asp Ser Asn Cys Gly Leu Ser Ser Thr Tyr Trp Tyr Arg Lys Lys Ser 
                405                 410                 415     


Gly Ser Thr Asn Glu Glu Ser Ile Ser Lys Gly Gly Arg Tyr Val Glu 
            420                 425                 430         


Thr Ile Asn Glu Gly Ser Lys Ser Phe Ser Leu Arg Ile Asn Asp Leu 
        435                 440                 445             


Thr Val Glu Asp Ser Gly Thr Tyr Arg Cys Lys Leu Ser Trp Trp Thr 
    450                 455                 460                 


Gln Asn Trp Arg Cys Ser Asn Ser Asp Val Tyr Gly Gly Gly Thr Lys 
465                 470                 475                 480 


Val Glu Ile Lys 
                


<210>  59
<211>  484
<212>  PRT
<213>  artificial sequence

<220>
<223>  soloMER D1-Fc-C4 Quad-X (NAR FW4)-Lead

<400>  59

Ala Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Arg Asp Ser His Cys Ala Thr Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Ala Ser Glu Cys Gln Tyr Gly Leu Ala Glu Tyr Asp Val 
                85                  90                  95      


Tyr Gly Gly Gly Thr Val Val Thr Val Asn Gly Ser Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
        115                 120                 125             


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
    130                 135                 140                 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
145                 150                 155                 160 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                165                 170                 175     


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            180                 185                 190         


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        195                 200                 205             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    210                 215                 220                 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
225                 230                 235                 240 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                245                 250                 255     


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            260                 265                 270         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        275                 280                 285             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    290                 295                 300                 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
305                 310                 315                 320 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                325                 330                 335     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly 
            340                 345                 350         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Gly Ser Ala Arg Val Asp Gln Ser Pro Ser Ser 
    370                 375                 380                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Val Leu Arg 
385                 390                 395                 400 


Asp Ser Asn Cys Gly Leu Ser Ser Thr Tyr Trp Tyr Arg Lys Lys Ser 
                405                 410                 415     


Gly Ser Thr Asn Glu Glu Ser Ile Ser Lys Gly Gly Arg Tyr Val Glu 
            420                 425                 430         


Thr Ile Asn Glu Gly Ser Lys Ser Phe Ser Leu Arg Ile Asn Asp Leu 
        435                 440                 445             


Thr Val Glu Asp Ser Gly Thr Tyr Arg Cys Lys Leu Ser Trp Trp Thr 
    450                 455                 460                 


Gln Asn Trp Arg Cys Ser Asn Ser Asp Val Tyr Gly Gly Gly Thr Val 
465                 470                 475                 480 


Val Thr Val Asn 
                


<210>  60
<211>  483
<212>  PRT
<213>  artificial sequence

<220>
<223>  WT D1-Fc-C4 Quad-X

<400>  60

Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Ser His Cys Ala Thr Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Ala Ser Glu Cys Gln Tyr Gly Leu Ala Glu Tyr Asp Val 
                85                  90                  95      


Tyr Gly Gly Gly Thr Val Val Thr Val Asn Gly Ser Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
        115                 120                 125             


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
    130                 135                 140                 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
145                 150                 155                 160 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                165                 170                 175     


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            180                 185                 190         


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        195                 200                 205             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    210                 215                 220                 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
225                 230                 235                 240 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                245                 250                 255     


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            260                 265                 270         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        275                 280                 285             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    290                 295                 300                 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
305                 310                 315                 320 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                325                 330                 335     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly 
            340                 345                 350         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Ala His Ser Ala Arg Val Asp Gln Thr Pro Gln Thr Ile 
    370                 375                 380                 


Thr Lys Glu Thr Gly Glu Ser Leu Thr Ile Asn Cys Val Leu Arg Asp 
385                 390                 395                 400 


Ser Asn Cys Gly Leu Ser Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly 
                405                 410                 415     


Ser Thr Asn Glu Glu Ser Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr 
            420                 425                 430         


Ile Asn Glu Gly Ser Lys Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr 
        435                 440                 445             


Val Glu Asp Ser Gly Thr Tyr Arg Cys Lys Leu Ser Trp Trp Thr Gln 
    450                 455                 460                 


Asn Trp Arg Cys Ser Asn Ser Asp Val Tyr Gly Gly Gly Thr Val Val 
465                 470                 475                 480 


Thr Val Asn 
            


<210>  61
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  P3A1

<400>  61

Thr Arg Val Asp Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Thr Asp Thr Ser Tyr Gly Leu Tyr 
            20                  25                  30          


Ser Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Thr Asp Trp Glu Arg 
        35                  40                  45              


Met Ser Ile Gly Gly Arg Tyr Val Glu Ser Val Asn Lys Gly Ala Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln Trp 
                85                  90                  95      


Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn 
            100                 105         


<210>  62
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  P3A1 V1

<400>  62

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Ser Tyr Gly Leu Tyr 
            20                  25                  30          


Ser Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Thr Asp Trp Glu Arg 
        35                  40                  45              


Met Ser Ile Gly Gly Arg Tyr Val Glu Ser Val Asn Lys Gly Ala Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln Trp 
                85                  90                  95      


Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  63
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  P3A1 V4

<400>  63

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Ser Tyr Gly Leu Tyr 
            20                  25                  30          


Ser Thr Ser Trp Phe Gln Gln Lys Pro Gly Thr Thr Asp Trp Glu Arg 
        35                  40                  45              


Met Ser Ile Gly Gly Arg Tyr Ser Gly Ser Gly Ser Lys Gly Ala Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Arg Glu Ala Arg His Pro Trp Leu Arg Gln Trp 
                85                  90                  95      


Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  64
<211>  105
<212>  PRT
<213>  artificial sequence

<220>
<223>  E4WT

<400>  64

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Thr Asp Thr Lys Tyr Leu Tyr Ser 
            20                  25                  30          


Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Thr Asp Trp Glu Arg Met 
        35                  40                  45              


Ser Ile Gly Gly Arg Tyr Val Glu Ser Val Asn Lys Gly Ala Lys Ser 
    50                  55                  60                  


Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr Tyr 
65                  70                  75                  80  


Ile Cys Arg Ala Trp Thr Ser Phe Glu Glu Gln Val Lys Asp Val Tyr 
                85                  90                  95      


Gly Ala Gly Thr Val Leu Thr Val Asn 
            100                 105 


<210>  65
<211>  105
<212>  PRT
<213>  artificial sequence

<220>
<223>  E4V1

<400>  65

Ala Ser Val Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Lys Tyr Leu Tyr Ser 
            20                  25                  30          


Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Thr Asp Trp Glu Arg Met 
        35                  40                  45              


Ser Ile Gly Gly Arg Tyr Val Glu Ser Val Asn Lys Gly Ala Lys Ser 
    50                  55                  60                  


Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr Tyr 
65                  70                  75                  80  


Ile Cys Arg Ala Trp Thr Ser Phe Glu Glu Gln Val Lys Asp Val Tyr 
                85                  90                  95      


Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105 


<210>  66
<211>  105
<212>  PRT
<213>  artificial sequence

<220>
<223>  E4V2

<400>  66

Ala Ser Val Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Lys Tyr Leu Tyr Ser 
            20                  25                  30          


Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Thr Asp Trp Glu Arg Met 
        35                  40                  45              


Ser Ile Gly Gly Arg Tyr Val Glu Ser Val Asn Lys Gly Ala Lys Ser 
    50                  55                  60                  


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
65                  70                  75                  80  


Tyr Cys Arg Ala Trp Thr Ser Phe Glu Glu Gln Val Lys Asp Val Tyr 
                85                  90                  95      


Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105 


<210>  67
<211>  105
<212>  PRT
<213>  artificial sequence

<220>
<223>  E4V3

<400>  67

Ala Ser Val Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Lys Tyr Leu Tyr Ser 
            20                  25                  30          


Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Thr Asp Trp Glu Arg Met 
        35                  40                  45              


Ser Ile Gly Gly Arg Phe Ser Gly Ser Gly Ser Lys Gly Ala Lys Ser 
    50                  55                  60                  


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
65                  70                  75                  80  


Tyr Cys Arg Ala Trp Thr Ser Phe Glu Glu Gln Val Lys Asp Val Tyr 
                85                  90                  95      


Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105 


<210>  68
<211>  105
<212>  PRT
<213>  artificial sequence

<220>
<223>  E4V4

<400>  68

Ala Ser Val Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Lys Tyr Leu Tyr Ser 
            20                  25                  30          


Thr Ser Trp Tyr Gln Gln Lys Pro Gly Thr Thr Asp Trp Glu Arg Met 
        35                  40                  45              


Ser Ile Gly Gly Arg Tyr Val Glu Ser Val Asn Lys Gly Ala Lys Ser 
    50                  55                  60                  


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
65                  70                  75                  80  


Tyr Cys Arg Ala Trp Thr Ser Phe Glu Glu Gln Val Lys Asp Val Tyr 
                85                  90                  95      


Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105 


<210>  69
<211>  105
<212>  PRT
<213>  artificial sequence

<220>
<223>  E4V5

<400>  69

Ala Ser Val Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Lys Tyr Leu Tyr Ser 
            20                  25                  30          


Thr Ser Trp Tyr Gln Gln Lys Pro Gly Thr Thr Asp Trp Glu Arg Met 
        35                  40                  45              


Ser Ile Gly Gly Arg Phe Ser Gly Ser Gly Ser Lys Gly Ala Lys Ser 
    50                  55                  60                  


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
65                  70                  75                  80  


Tyr Cys Arg Ala Trp Thr Ser Phe Glu Glu Gln Val Lys Asp Val Tyr 
                85                  90                  95      


Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105 


<210>  70
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  78WT

<400>  70

Thr Arg Val Asp Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Thr Asp Thr Asn Tyr Ser Leu Tyr 
            20                  25                  30          


Ala Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Thr Asp Trp Glu Arg 
        35                  40                  45              


Met Ser Ile Gly Gly Arg Tyr Val Glu Ser Val Asn Lys Gly Ala Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Ile Cys Arg Ala Val Trp Phe Pro Tyr Phe Ile Ser Asp Met Trp 
                85                  90                  95      


Asp Val Tyr Gly Ala Gly Thr Val Leu Thr Val Asn 
            100                 105             


<210>  71
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  78V1

<400>  71

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Asn Tyr Ser Leu Tyr 
            20                  25                  30          


Ala Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Thr Asp Trp Glu Arg 
        35                  40                  45              


Met Ser Ile Gly Gly Arg Tyr Val Glu Ser Val Asn Lys Gly Ala Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Ile Cys Arg Ala Val Trp Phe Pro Tyr Phe Ile Ser His Met Trp 
                85                  90                  95      


Asp Val Tyr Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  72
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  78V2

<400>  72

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Asn Tyr Ser Leu Tyr 
            20                  25                  30          


Ala Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Thr Asp Trp Glu Arg 
        35                  40                  45              


Met Ser Ile Gly Gly Arg Tyr Val Glu Ser Val Asn Lys Gly Ala Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Val Trp Phe Pro Tyr Phe Ile Ser Asp Met Trp 
                85                  90                  95      


Asp Val Tyr Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  73
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  78V3

<400>  73

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Asn Tyr Ser Leu Tyr 
            20                  25                  30          


Ala Thr Ser Trp Tyr Gln Gln Lys Pro Gly Lys Thr Asp Trp Glu Arg 
        35                  40                  45              


Met Ser Ile Gly Gly Arg Tyr Val Glu Ser Val Asn Lys Gly Ala Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Val Trp Phe Pro Tyr Phe Ile Ser Asp Met Trp 
                85                  90                  95      


Asp Val Tyr Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  74
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  78V4

<400>  74

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Asn Tyr Ser Leu Tyr 
            20                  25                  30          


Ala Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Thr Asp Trp Glu Arg 
        35                  40                  45              


Met Ser Ile Gly Gly Arg Phe Ser Gly Ser Gly Ser Lys Gly Ala Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Val Trp Phe Pro Tyr Phe Ile Ser Asp Met Trp 
                85                  90                  95      


Asp Val Tyr Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  75
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  78V5

<400>  75

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Asn Tyr Ser Leu Tyr 
            20                  25                  30          


Ala Thr Ser Trp Tyr Gln Gln Lys Pro Gly Lys Thr Asp Trp Glu Arg 
        35                  40                  45              


Met Ser Ile Gly Gly Arg Phe Ser Gly Ser Gly Ser Lys Gly Ala Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Val Trp Phe Pro Tyr Phe Ile Ser Asp Met Trp 
                85                  90                  95      


Asp Val Tyr Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  76
<211>  105
<212>  PRT
<213>  artificial sequence

<220>
<223>  E4V2B09

<400>  76

Ala Ser Val Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Gly Thr Gly Tyr Trp Tyr Ser 
            20                  25                  30          


Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Ser Asn Glu Asp Arg Ile 
        35                  40                  45              


Ile Ile Gly Gly Arg Tyr Val Glu Ser Val Asn Lys Gly Thr Lys Ser 
    50                  55                  60                  


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
65                  70                  75                  80  


Tyr Cys Arg Ala Trp Thr Ser Phe Glu Glu Gln Val Lys Asp Val Tyr 
                85                  90                  95      


Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105 


<210>  77
<211>  105
<212>  PRT
<213>  artificial sequence

<220>
<223>  E4V2D10

<400>  77

Ala Ser Val Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Gly Ala Gly Tyr Trp Phe Ala 
            20                  25                  30          


Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Ser Asp Lys Glu Ser Ile 
        35                  40                  45              


Ser Asn Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Ser Met Ser 
    50                  55                  60                  


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
65                  70                  75                  80  


Tyr Cys Arg Ala Trp Thr Ser Phe Glu Glu Gln Val Lys Asp Val Tyr 
                85                  90                  95      


Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105 


<210>  78
<211>  105
<212>  PRT
<213>  artificial sequence

<220>
<223>  E4V2F3

<400>  78

Ala Ser Val Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Asn Tyr Trp Tyr Ser 
            20                  25                  30          


Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Thr Asn Glu Asp Arg Ile 
        35                  40                  45              


Ile Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Asn Gly Pro Lys Ser 
    50                  55                  60                  


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
65                  70                  75                  80  


Tyr Cys Arg Ala Trp Thr Ser Phe Glu Glu Gln Val Lys Asp Val Tyr 
                85                  90                  95      


Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105 


<210>  79
<211>  105
<212>  PRT
<213>  artificial sequence

<220>
<223>  E4V2Cc8

<400>  79

Ala Ser Val Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Ser Ala Gly Tyr Leu Tyr Ala 
            20                  25                  30          


Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Ser Asp Lys Glu Ser Met 
        35                  40                  45              


Ile Ile Gly Arg Arg Tyr Val Glu Ser Val Asn Asn Arg Ser Met Ser 
    50                  55                  60                  


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
65                  70                  75                  80  


Tyr Cys Arg Ala Trp Thr Ser Phe Glu Glu Gln Val Lys Asp Val Tyr 
                85                  90                  95      


Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105 


<210>  80
<211>  105
<212>  PRT
<213>  artificial sequence

<220>
<223>  E4V2Cc9

<400>  80

Ala Ser Val Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Gly Thr Glu Tyr Leu Tyr Ser 
            20                  25                  30          


Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Pro Asn Glu Asp Arg Met 
        35                  40                  45              


Ile Asn Gly Gly Arg Tyr Val Glu Ser Val Asn Lys Gly Thr Met Ser 
    50                  55                  60                  


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
65                  70                  75                  80  


Tyr Cys Arg Ala Trp Thr Ser Phe Glu Glu Gln Val Lys Asp Val Tyr 
                85                  90                  95      


Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105 


<210>  81
<211>  105
<212>  PRT
<213>  artificial sequence

<220>
<223>  E4V2Ee6

<400>  81

Ala Ser Val Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Arg Tyr Leu Tyr Ala 
            20                  25                  30          


Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Thr Asn Lys Glu Ser Ile 
        35                  40                  45              


Ser Asn Gly Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Ser Met Ser 
    50                  55                  60                  


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
65                  70                  75                  80  


Tyr Cys Arg Ala Trp Thr Ser Phe Glu Glu Gln Val Lys Asp Val Tyr 
                85                  90                  95      


Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105 


<210>  82
<211>  105
<212>  PRT
<213>  artificial sequence

<220>
<223>  E4V2Ee8

<400>  82

Ala Ser Val Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Gly Ala Ser Tyr Trp Tyr Ser 
            20                  25                  30          


Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Thr Asp Glu Glu Ser Met 
        35                  40                  45              


Ser Asn Gly Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Pro Met Ser 
    50                  55                  60                  


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
65                  70                  75                  80  


Tyr Cys Arg Ala Trp Thr Ser Phe Glu Glu Gln Val Lys Asp Val Tyr 
                85                  90                  95      


Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105 


<210>  83
<211>  105
<212>  PRT
<213>  artificial sequence

<220>
<223>  E4V2Gg11

<400>  83

Ala Ser Val Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Gly Thr Arg Tyr Trp Phe Ser 
            20                  25                  30          


Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Thr Asp Glu Asp Ser Ile 
        35                  40                  45              


Ser Asn Gly Gly Arg Tyr Val Glu Ser Val Asn Asn Gly Ser Met Ser 
    50                  55                  60                  


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
65                  70                  75                  80  


Tyr Cys Arg Ala Trp Thr Ser Phe Glu Glu Gln Val Lys Asp Val Tyr 
                85                  90                  95      


Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105 


<210>  84
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  D3WT

<400>  84

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Thr Asp Thr Ser Tyr Gly Leu Tyr 
            20                  25                  30          


Ser Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Thr Asp Trp Glu Arg 
        35                  40                  45              


Met Ser Ile Gly Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Ala Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Gln Ser Gly Met Ala Ile Ser Thr Gly Ser Gly 
                85                  90                  95      


His Gly Tyr Asn Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn 
            100                 105                 110         


<210>  85
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  D3WT V1

<400>  85

Ala Ser Val Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Ser Tyr Gly Leu Tyr 
            20                  25                  30          


Ser Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Thr Asp Trp Glu Arg 
        35                  40                  45              


Met Ser Ile Gly Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Ala Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Gln Ser Gly Met Ala Ile Ser Thr Gly Ser Gly 
                85                  90                  95      


His Gly Tyr Asn Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  86
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  D3WT V2

<400>  86

Ala Ser Val Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Ser Tyr Gly Leu Tyr 
            20                  25                  30          


Ser Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Thr Asp Trp Glu Arg 
        35                  40                  45              


Met Ser Ile Gly Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Ala Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Gln Ser Gly Met Ala Ile Ser Thr Gly Ser Gly 
                85                  90                  95      


His Gly Tyr Asn Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  87
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  D3WT V4

<400>  87

Ala Ser Val Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Ser Tyr Gly Leu Tyr 
            20                  25                  30          


Ser Thr Ser Trp Tyr Gln Gln Lys Pro Gly Thr Thr Asp Trp Glu Arg 
        35                  40                  45              


Met Ser Ile Gly Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Ala Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Gln Ser Gly Met Ala Ile Ser Thr Gly Ser Gly 
                85                  90                  95      


His Gly Tyr Asn Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  88
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  D3WT V5

<400>  88

Ala Ser Val Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Ser Tyr Gly Leu Tyr 
            20                  25                  30          


Ser Thr Ser Trp Tyr Gln Gln Lys Pro Gly Thr Thr Asp Trp Glu Arg 
        35                  40                  45              


Met Ser Ile Gly Gly Arg Phe Ser Gly Ser Gly Ser Lys Arg Ala Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Gln Ser Gly Met Ala Ile Ser Thr Gly Ser Gly 
                85                  90                  95      


His Gly Tyr Asn Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  89
<211>  25
<212>  PRT
<213>  artificial sequence

<220>
<223>  D3V2 FW1

<400>  89

Ala Ser Val Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr 
            20                  25  


<210>  90
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  D3V2 CDR1

<400>  90

Asp Thr Ser Tyr Gly Leu Tyr Ser 
1               5               


<210>  91
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  D3V2 FW2

<400>  91

Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr 
1               5                   10  


<210>  92
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  D3V2 HV2

<400>  92

Thr Asp Trp Glu Arg Met Ser Ile Gly 
1               5                   


<210>  93
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  D3V2 FW3a

<400>  93

Gly Arg Tyr Val Glu Ser Val Asn 
1               5               


<210>  94
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  D3V2 HV4

<400>  94

Lys Arg Ala Lys Ser 
1               5   


<210>  95
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  D3V2 FW3b

<400>  95

Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
1               5                   10                  15      


Tyr Cys Lys Ala 
            20  


<210>  96
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  D3V2 CDR3

<400>  96

Gln Ser Gly Met Ala Ile Ser Thr Gly Ser Gly His Gly Tyr Asn Trp 
1               5                   10                  15      


Tyr 
    


<210>  97
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  D3V2 FW4

<400>  97

Asp Gly Ala Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  98
<211>  228
<212>  PRT
<213>  artificial sequence

<220>
<223>  D3 V2 PAN3 F11

<400>  98

Ala Ser Val Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Asn Tyr Gly Leu Tyr 
            20                  25                  30          


Ala Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Ser Asn Glu Asp Arg 
        35                  40                  45              


Ile Ile Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Gln Ser Gly Met Ala Ile Ser Thr Gly Ser Gly 
                85                  90                  95      


His Gly Tyr Asn Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Gln Ala Ser Gly Ala Ala Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
        115                 120                 125             


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
    130                 135                 140                 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
145                 150                 155                 160 


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
                165                 170                 175     


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
            180                 185                 190         


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
        195                 200                 205             


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Ser His His 
    210                 215                 220                 


His His His His 
225             


<210>  99
<211>  228
<212>  PRT
<213>  artificial sequence

<220>
<223>  D3 V2 PAN3 E08

<400>  99

Ala Ser Val Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Arg Tyr Gly Leu Tyr 
            20                  25                  30          


Ser Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Thr Asp Lys Glu Arg 
        35                  40                  45              


Ile Ser Ile Gly Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Gln Ser Gly Met Ala Ile Ser Thr Gly Ser Gly 
                85                  90                  95      


His Gly Tyr Asn Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Gln Ala Ser Gly Ala Ala Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
        115                 120                 125             


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
    130                 135                 140                 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
145                 150                 155                 160 


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
                165                 170                 175     


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
            180                 185                 190         


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
        195                 200                 205             


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Ser His His 
    210                 215                 220                 


His His His His 
225             


<210>  100
<211>  228
<212>  PRT
<213>  artificial sequence

<220>
<223>  D3 V2 PAN F01

<400>  100

Ala Ser Val Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Lys Tyr Gly Leu Tyr 
            20                  25                  30          


Ser Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Thr Asp Lys Glu Arg 
        35                  40                  45              


Ile Ser Ile Gly Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Thr Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Gln Ser Gly Met Ala Ile Ser Thr Gly Ser Gly 
                85                  90                  95      


His Gly Tyr Asn Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Gln Ala Ser Gly Ala Ala Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
        115                 120                 125             


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
    130                 135                 140                 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
145                 150                 155                 160 


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
                165                 170                 175     


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
            180                 185                 190         


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
        195                 200                 205             


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Ser His His 
    210                 215                 220                 


His His His His 
225             


<210>  101
<211>  228
<212>  PRT
<213>  artificial sequence

<220>
<223>  D3 V2 PAN G02

<400>  101

Ala Ser Val Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Asn Tyr Gly Leu Tyr 
            20                  25                  30          


Ala Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Thr Asp Glu Glu Arg 
        35                  40                  45              


Met Ser Ile Gly Gly Arg Tyr Val Glu Ser Val Asn Lys Arg Ser Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Gln Ser Gly Met Ala Ile Ser Thr Gly Ser Gly 
                85                  90                  95      


His Gly Tyr Asn Trp Tyr Asp Gly Ala Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Gln Ala Ser Gly Ala Ala Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
        115                 120                 125             


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
    130                 135                 140                 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
145                 150                 155                 160 


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
                165                 170                 175     


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
            180                 185                 190         


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
        195                 200                 205             


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Ser His His 
    210                 215                 220                 


His His His His 
225             


