                         SEQUENCE LISTING

<110>  Erber Aktiengesellschaft
 
<120>  MEANS AND METHODS FOR DETOXIFYING OCHRATOXIN A

<130>  ERB17210PCT

<150>  EP20215495
<151>  2020-12-18

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OTA hydrolyzing polypeptide 1

<400>  1

Met Ser Asp His Leu Pro Ala Asp Val Arg Asp Leu Ile Arg Gln Thr 
1               5                   10                  15      


Met Ser Arg Leu Glu Asn Leu Val Pro Pro Ser Ala Ala Phe Asp Asp 
            20                  25                  30          


Glu Thr Gln Asp Ala Val Phe Glu Ala Ile Asp Ser Ile Asp Gly Asp 
        35                  40                  45              


Met Leu Ala Leu Asn Lys Ala Ile His Asp Asn Pro Glu Leu Gly Phe 
    50                  55                  60                  


His Glu Val Lys Ala His His His Leu Val Gln Ala Leu Ile Lys Leu 
65                  70                  75                  80  


Gly Phe Ala Val Thr Asn Pro Thr Ser Leu Pro Thr Ala Phe Val Ala 
                85                  90                  95      


Thr Trp Ser His Gly Ser Gly Gly Arg Thr Phe Gly Phe Asn Ala Glu 
            100                 105                 110         


Tyr Asp Ala Leu Pro Gly Val Gly His Ala Cys Gly His Asn Leu Ile 
        115                 120                 125             


Ala Ile Val Ala Val Ala Ser Ala Ala Gly Leu Lys Ala Ala Leu Lys 
    130                 135                 140                 


Ala Arg Asn Ile Pro Gly Thr Ile Lys Val Ile Gly Ser Pro Ala Glu 
145                 150                 155                 160 


Glu Gly Gly Gly Gly Lys Val Ile Leu Leu Asn Glu Gly Ala Tyr Asp 
                165                 170                 175     


Gly Ile Asp Ala Cys Val Met Ala His Pro Glu Gly Gly Val Pro Gly 
            180                 185                 190         


Ile Asp Asp Asp Gly Ser Ala Tyr Thr Ser Gly Pro Ala Thr Leu Ala 
        195                 200                 205             


Arg Ala Gly Phe Ser Val Glu Leu Phe Gly Lys Ala Ala His Ala Gly 
    210                 215                 220                 


Ala Ala Pro Trp Leu Gly Val Asn Ala Leu Asp Ala Ala Val Gln Gly 
225                 230                 235                 240 


Tyr Thr Ala Val Ser Met Leu Arg Gln Gln Ile Glu Pro Thr Met Arg 
                245                 250                 255     


Val His Gly Val Phe Asp Tyr Gly Lys Glu Lys Trp Val Gln Asn Ile 
            260                 265                 270         


Ile Pro Ala Tyr Ala Lys Val Glu Tyr Ser Thr Arg Ala Leu Asp Val 
        275                 280                 285             


Lys Ser Thr Leu Glu Leu Arg Lys Lys Val Ile Ser Cys Phe Glu Ser 
    290                 295                 300                 


Ala Ala Thr Ala Thr Gly Cys Thr His Lys Val Ser Ala Pro Glu Thr 
305                 310                 315                 320 


Glu Val Tyr Ala Glu Leu Arg Asn Asn Val Thr Leu Ala Asp Ala Tyr 
                325                 330                 335     


Ala Asp Phe Met Thr Thr Ala Phe Gly Gln Lys Ile Gly Arg Val Gly 
            340                 345                 350         


Ile Thr Thr Ala Ser Thr Asp Phe Gly Asn Val Thr Tyr Lys Met Pro 
        355                 360                 365             


Ala Ile His Pro Gly Phe His Leu Ile Ser Lys Gly Val Asn His Thr 
    370                 375                 380                 


Pro Glu Phe Ala Asp Ala Ala Gly Thr Leu Asp Ala His Glu Arg Ala 
385                 390                 395                 400 


Ile Lys Val Ala Lys Gly Leu Ala Met Leu Gly Ala Lys Phe Leu Gln 
                405                 410                 415     


Asp Asp Lys Phe Ala Lys Glu Val Lys Arg Lys Phe Asp Glu Phe Lys 
            420                 425                 430         


Lys Glu Val Gly Glu Leu Lys Leu Thr Asp Asn Glu Asn Glu Val Gln 
        435                 440                 445             


Glu Val Asn Gly Val Met Lys Gln Glu His Ile Ala Glu Gln Val Asp 
    450                 455                 460                 


Glu Ile Trp Leu 
465             


<210>  2
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OTA hydrolyzing polypeptide 2

<400>  2

Met Ala Arg Asp Glu Ile Pro Ala Asp Val Lys Ala Leu Ile Ala Gln 
1               5                   10                  15      


Thr Val Thr Ala Leu His Gly Leu Ala Pro Pro Ser Ala Glu Phe Asp 
            20                  25                  30          


Asp Glu Thr Gln Asp Ala Val Phe Glu Ala Ile Asp Ala Ile Asp Gly 
        35                  40                  45              


Ala Met Trp Asp Leu Asn Lys Lys Ile His Asp His Pro Glu Leu Gly 
    50                  55                  60                  


Phe Lys Glu His Lys Ala Arg Ala Asn Leu Val Ala Ala Leu Cys Lys 
65                  70                  75                  80  


Leu Gly Phe Thr Val Thr Asn Pro Ser Ser Leu Pro Thr Ala Phe Val 
                85                  90                  95      


Ala Thr Tyr Thr Gln Gly His Gly Gly Arg Thr Phe Gly Val Asp Ala 
            100                 105                 110         


Glu Tyr Asp Ala Leu Pro Glu Val Gly His Ala Cys Gly His Asn Leu 
        115                 120                 125             


Ile Ala Val Ala Ala Val Ala Ala Ala Ala Gly Leu Lys Ala Ala Leu 
    130                 135                 140                 


Lys Ala Arg Asn Ile Ala Gly Thr Ile Lys Leu Ile Gly Ser Pro Ala 
145                 150                 155                 160 


Glu Glu Gly Gly Gly Gly Lys Val Ile Leu Leu Asn Glu Gly Val Tyr 
                165                 170                 175     


Asp Cys Leu Asp Ala Cys Val Met Ala His Pro Glu Gly Gly Met Ile 
            180                 185                 190         


Gly Asn Asp Tyr Asp Gly Ser Ala Tyr Val Gly Gly Pro Ala Ser Leu 
        195                 200                 205             


Ala Arg Ala Gly Phe Glu Ile Glu Phe His Gly Arg Gly Ala His Ala 
    210                 215                 220                 


Gly Ala Ala Pro Trp Leu Gly Ile Asn Ala Leu Asp Ala Ala Val Gln 
225                 230                 235                 240 


Gly Tyr Thr Ala Val Ser Met Leu Arg Gln Gln Leu Glu Pro Thr Met 
                245                 250                 255     


Arg Val His Gly Ile Ile Gln Gly Ser Glu Lys Trp Ala Gln Asn Ile 
            260                 265                 270         


Ile Pro Ser Tyr Ala Lys Val Ser Tyr Ser Thr Arg Ala Leu Asp Val 
        275                 280                 285             


Lys Lys Thr Leu Glu Leu Arg Asp Lys Thr Val Asp Cys Phe Ala Ser 
    290                 295                 300                 


Ala Ala Lys Ala Thr Gly Cys Thr Tyr Glu Leu Thr Ala Pro Glu Thr 
305                 310                 315                 320 


Glu Val Tyr Ala Glu Leu Arg Asn Asn Glu Pro Leu Ala Asp Ala Tyr 
                325                 330                 335     


Ala Asp Leu Met Thr His Ala Phe Gly Gln Lys Ile Glu Arg Arg Gly 
            340                 345                 350         


Met Thr Thr Ala Ser Thr Asp Phe Gly Asn Val Thr Tyr His Val Pro 
        355                 360                 365             


Ala Ile His Pro Gly Phe Thr Ile Glu Ser Asp Thr Val Asn His Thr 
    370                 375                 380                 


Ala Gly Phe Thr Glu Ala Ala Gly Lys Lys Gly Ala His Glu Arg Thr 
385                 390                 395                 400 


Met Lys Val Ala Lys Gly Leu Ala Met Val Gly Ala Lys Phe Leu Ala 
                405                 410                 415     


Asp Asp Lys Phe Ala Lys Asp Val Arg Lys Ala Phe Glu Lys Phe Lys 
            420                 425                 430         


Lys Gly Ala Gln 
        435     


<210>  3
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OTA hydrolyzing polypeptide 3

<400>  3

Met Ala Arg Asp Glu Ile Pro Ala Asp Val Lys Ala Leu Ile Ala Gln 
1               5                   10                  15      


Thr Val Thr Ala Leu His Gly Leu Ala Pro Pro Ser Ala Glu Phe Asp 
            20                  25                  30          


Asp Glu Thr Gln Asp Ala Val Phe Glu Ala Ile Asp Ala Ile Asp Asp 
        35                  40                  45              


Ala Met Trp Asp Leu Asn Lys Lys Ile His Asp His Pro Glu Leu Gly 
    50                  55                  60                  


Phe Glu Glu His Lys Ala Arg Ala Asn Leu Val Ala Ala Leu Cys Lys 
65                  70                  75                  80  


Leu Gly Phe Thr Val Thr Asn Pro Ser Ser Leu Pro Thr Ala Phe Val 
                85                  90                  95      


Ala Thr Tyr Thr His Gly His Gly Gly Arg Thr Phe Gly Val Asp Ala 
            100                 105                 110         


Glu Tyr Asp Ala Leu Arg Asp Val Gly His Ala Cys Gly His Asn Leu 
        115                 120                 125             


Ile Ala Val Ala Ala Val Ala Ala Ala Ala Gly Leu Lys Ala Ala Leu 
    130                 135                 140                 


Lys Ala Arg Asn Ile Ser Gly Thr Val Lys Leu Ile Gly Ser Pro Ala 
145                 150                 155                 160 


Glu Glu Gly Gly Gly Gly Lys Val Ile Leu Leu Asn Glu Gly Val Tyr 
                165                 170                 175     


Asp Cys Leu Asp Ala Cys Val Met Ala His Pro Glu Gly Gly Met Ile 
            180                 185                 190         


Gly Asp Asp Tyr Asp Gly Ser Ala Tyr Val Gly Gly Pro Ala Ser Leu 
        195                 200                 205             


Ala Arg Ala Gly Phe Glu Ile Glu Phe His Gly Arg Gly Ala His Ala 
    210                 215                 220                 


Gly Ala Ala Pro Trp Leu Gly Ile Asn Ala Leu Asp Ala Ala Val Gln 
225                 230                 235                 240 


Gly Tyr Thr Ala Val Ser Met Leu Arg Gln Gln Leu Glu Pro Thr Met 
                245                 250                 255     


Arg Val His Gly Ile Ile Gln Gly Ser Glu Lys Trp Ala Gln Asn Ile 
            260                 265                 270         


Ile Pro Ser Tyr Ala Lys Val Ser Tyr Ser Thr Arg Ala Leu Asp Val 
        275                 280                 285             


Lys Lys Thr Leu Glu Leu Arg Asp Lys Thr Val Asp Cys Phe Ala Ser 
    290                 295                 300                 


Ala Ala Lys Ala Thr Gly Cys Thr Tyr Asp Val Thr Ala Pro Glu Thr 
305                 310                 315                 320 


Glu Val Tyr Ala Glu Leu Arg Asn Asn Gln Pro Leu Ala Asp Ala Tyr 
                325                 330                 335     


Ala Asp Leu Met Thr Lys Ala Phe Gly Gln Lys Ile Glu Arg Arg Gly 
            340                 345                 350         


Met Thr Thr Ala Ser Thr Asp Phe Gly Asn Val Thr Tyr His Leu Pro 
        355                 360                 365             


Ala Ile His Pro Gly Phe Thr Ile Glu Ser Glu Thr Val Asn His Thr 
    370                 375                 380                 


Lys Gly Phe Thr Glu Ala Ala Gly Lys Lys Asp Ala His Glu Arg Thr 
385                 390                 395                 400 


Met Lys Val Ala Lys Gly Leu Ala Met Val Gly Ala Lys Phe Leu Ala 
                405                 410                 415     


Asp Asp Lys Phe Ala Lys Asp Val Arg Lys Ala Phe Glu Lys Phe Lys 
            420                 425                 430         


Arg Glu Val Glu 
        435     


<210>  4
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OTA hydrolyzing polypeptide 4

<400>  4

Met Ala Arg Asp Pro Leu Pro Ala Asp Val Arg Leu Leu Ile Arg Asn 
1               5                   10                  15      


Asn Met Ala Ser Ala His Pro Gln Val Pro Thr Ile Asp Gly Leu Asp 
            20                  25                  30          


Ser Lys Thr Gln Asn Asp Val Phe Thr Ala Ile Asp Ala Ile Asn Asn 
        35                  40                  45              


Asp Met Arg Asp Leu Ser Leu Ala Ile His Glu Asn Pro Glu Leu Gly 
    50                  55                  60                  


Phe Lys Glu Val Lys Ala His Ala Asn Leu Val Lys Ala Leu Ser Lys 
65                  70                  75                  80  


Leu Gly Phe Thr Ile Thr Asn Pro Thr Ser Leu Glu Thr Ala Phe Val 
                85                  90                  95      


Ala Thr Trp Ser Asn Gly Ser Gly Gly Arg Thr Phe Gly Phe Asn Ala 
            100                 105                 110         


Glu Tyr Asp Ala Leu Pro Gly Ile Gly His Ala Cys Gly His Asn Leu 
        115                 120                 125             


Ile Ala Ile Val Ala Val Ala Ser Ala Val Gly Cys Lys Ala Ala Met 
    130                 135                 140                 


Glu Lys Gln Gly Ile Ser Gly Thr Ile Lys Val Ile Gly Ser Pro Ala 
145                 150                 155                 160 


Glu Glu Gly Gly Gly Gly Lys Ile Ile Leu Phe Asn Glu Gly Val Tyr 
                165                 170                 175     


Asp Gly Leu Asp Ala Cys Ala Met Ala His Pro Gly Gly Gly Met Pro 
            180                 185                 190         


Ala Asp Gly Tyr Asp Gly Gln Ala Pro Ala Glu Gly Lys Pro Ala Ser 
        195                 200                 205             


Leu Ala Arg Ala Gly Phe Ile Val Asp Phe Val Gly Lys Pro Ala His 
    210                 215                 220                 


Ala Gly Ala Ala Pro Trp Met Gly Val Asn Ala Val Asp Ala Ala Val 
225                 230                 235                 240 


Leu Gly Tyr Asn Gly Val Ser Met Leu Arg Gln Gln Leu Glu Pro Thr 
                245                 250                 255     


Val Arg Val His Gly Val Ile Arg Gly Pro Asn Asp Trp Val Asn Asn 
            260                 265                 270         


Ile Ile Pro Ala Ser Ser His Val Glu Tyr Asp Val Arg Ala Pro Asp 
        275                 280                 285             


Val Lys Gln Ala Met Ala Val Arg Asn Lys Ala Ile Ala Cys Phe Glu 
    290                 295                 300                 


Ser Ala Ala His Ala Thr Gly Cys Ser His Thr Thr Gln Ser Lys Asp 
305                 310                 315                 320 


Lys Asp Ile Tyr Ala Glu Leu Arg Asn Ser Ile Arg Met Ala Gly Val 
                325                 330                 335     


Tyr Ala Asp Ile Met Glu Glu Val Phe Asp Gln His Ile Gln Arg Asp 
            340                 345                 350         


Gly Met Thr Thr Ala Ser Thr Asp Phe Gly Asn Ile Thr Ile Ser Ala 
        355                 360                 365             


Cys Pro Ala Val His Pro Met Tyr Leu Ile Glu Thr Asp Gly Val Asn 
    370                 375                 380                 


His Thr Pro Glu Phe Thr Ala Gly Ala Ala Thr Met Asp Ser His Glu 
385                 390                 395                 400 


Arg Ser Ile Lys Val Ala Lys Gly Leu Ala Leu Leu Gly Phe Lys Val 
                405                 410                 415     


Leu Thr Asp Asp Val Phe Ala Lys Lys Ile Lys Asp Glu Phe Glu Glu 
            420                 425                 430         


Gln Lys Lys Arg Leu Gly Ala 
        435                 


<210>  5
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conservative motif

<400>  5

Gly His Ala Cys Gly His Asn Leu Ile Ala 
1               5                   10  


<210>  6
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conservative motif

<400>  6

Ile Gly Ser Pro Ala Glu Glu Gly Gly Gly Gly Lys 
1               5                   10          


<210>  7
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conservative motif

<400>  7

Met Ala His Pro 
1               


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conservative motif

<400>  8

Ala His Ala Gly Ala Ala Pro Trp 
1               5               


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conservative motif

<400>  9

Lys Val Ala Lys Gly Leu Ala 
1               5           


<210>  10
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conservative motif

<400>  10

Ile Gly Ser Pro Ala Glu Glu Gly Gly Gly Gly Lys Val Ile Leu 
1               5                   10                  15  


<210>  11
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conservative motif

<400>  11

Ile Gly Ser Pro Ala Glu Glu Gly Gly Gly Gly Lys Val Ile Leu 
1               5                   10                  15  


<210>  12
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conservative motif

<400>  12

Pro Glu Leu Gly Phe His Glu Val Lys Ala 
1               5                   10  


<210>  13
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conservative motif

<400>  13

Thr Asn Pro Thr Ser Leu Pro Thr Ala Phe Val Ala Thr 
1               5                   10              


<210>  14
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conservative motif

<400>  14

Gly Gly Arg Thr Phe Gly Phe Asn Ala Glu Tyr Asp Ala Leu 
1               5                   10                  


<210>  15
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conservative motif

<400>  15

Gly His Ala Cys Gly His Asn Leu Ile Ala Ile Val Ala Val Ala Ser 
1               5                   10                  15      


Ala 
    


<210>  16
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conservative motif

<400>  16

Ile Pro Gly Thr Ile Lys Val Ile Gly Ser Pro Ala Glu Glu Gly Gly 
1               5                   10                  15      


Gly Gly Lys Val Ile Leu Leu Asn Glu Gly 
            20                  25      


<210>  17
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conservative motif

<400>  17

Asp Ala Cys Val Met Ala His Pro Glu Gly Gly 
1               5                   10      


<210>  18
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conservative motif

<400>  18

Ala His Ala Gly Ala Ala Pro Trp Leu Gly Val Asn Ala Leu Asp Ala 
1               5                   10                  15      


Ala Val Gln Gly Tyr 
            20      


<210>  19
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conservative motif


<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (24)..(28)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (58)..(59)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (68)..(68)
<223>  Xaa can be any naturally occurring amino acid

<400>  19

Gly His Ala Cys Gly His Asn Leu Ile Ala Xaa Xaa Ala Val Ala Xaa 
1               5                   10                  15      


Ala Xaa Gly Xaa Lys Ala Ala Xaa Xaa Xaa Xaa Xaa Ile Xaa Gly Thr 
            20                  25                  30          


Xaa Lys Xaa Ile Gly Ser Pro Ala Glu Glu Gly Gly Gly Gly Lys Xaa 
        35                  40                  45              


Ile Leu Xaa Asn Glu Gly Xaa Tyr Asp Xaa Xaa Asp Ala Cys Xaa Met 
    50                  55                  60                  


Ala His Pro Xaa Gly Gly 
65                  70  


<210>  20
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M20 peptidase aminoacylase 1-like protein 2-like amidohydrolase 
       subfamily conservative motif


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be Lys or His

<400>  20

Cys His Glu His Xaa 
1               5   


<210>  21
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M20 peptidase aminoacylase 1-like protein 2-like amidohydrolase 
       subfamily conservative motif


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(37)
<223>  Xaa can be any naturally occurring amino acid

<400>  21

Cys Xaa His Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Glu 
        35              


<210>  22
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M20 peptidase aminoacylase 1-like protein 2-like amidohydrolase 
       subfamily conservative motif


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be Lys or His

<400>  22

Cys His Glu Glu His Xaa 
1               5       


<210>  23
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conservative motif

<400>  23

Val Asn His Thr 
1               


