                         SEQUENCE LISTING

<110>  Novo Nordisk A/S
 
<120>  SAFE IMMUNO-STEALTH CELLS

<130>  200094WO01

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Ser His Ser Leu Lys Tyr Phe His Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Asn Asp Ala Ala Ser Pro Arg Met Val Pro Arg 
        35                  40                  45              


Ala Pro Trp Met Glu Gln Glu Gly Ser Glu Tyr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Arg Ser Ala Arg Asp Thr Ala Gln Ile Phe Arg Val Asn Leu Arg Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln 
                85                  90                  95      


Trp Met His Gly Cys Glu Leu Gly Pro Asp Arg Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr Glu Gln Phe Ala Tyr Asp Gly Lys Asp Tyr Leu Thr Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Val Asp Thr Ala Ala Gln Ile Ser Glu 
    130                 135                 140                 


Gln Lys Ser Asn Asp Ala Ser Glu Ala Glu His Gln Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Asp Thr Cys Val Glu Trp Leu His Lys Tyr Leu Glu Lys Gly Lys 
                165                 170                 175     


Glu Thr Leu Leu His Leu Glu Pro Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Gln Asp Gly Glu Gly His 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro Val Thr Leu 
            260                 265                 270         


Arg Trp Lys Pro Ala Ser Gln Pro Thr Ile Pro Ile Val Gly Ile Ile 
        275                 280                 285             


Ala Gly Leu Val Leu Leu Gly Ser Val Val Ser Gly Ala Val Val Ala 
    290                 295                 300                 


Ala Val Ile Trp Arg Lys Lys Ser Ser Gly Gly Lys Gly Gly Ser Tyr 
305                 310                 315                 320 


Ser Lys Ala Glu Trp Ser Asp Ser Ala Gln Gly Ser Glu Ser His Ser 
                325                 330                 335     


Leu 
    


<210>  2
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  2

Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu 
1               5                   10                  15      


Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro 
            20                  25                  30          


Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys 
        35                  40                  45              


Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu 
    50                  55                  60                  


Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys 
65                  70                  75                  80  


Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp 
                85                  90                  95      


Arg Asp Met 
            


<210>  3
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  3

Gly Ser His Ser Leu Lys Tyr Phe His Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Asn Asp Ala Ala Ser Pro Arg Met Val Pro Arg 
        35                  40                  45              


Ala Pro Trp Met Glu Gln Glu Gly Ser Glu Tyr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Arg Ser Ala Arg Asp Thr Ala Gln Ile Phe Arg Val Asn Leu Arg Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln 
                85                  90                  95      


Trp Met His Gly Cys Glu Leu Gly Pro Asp Gly Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr Glu Gln Phe Ala Tyr Asp Gly Lys Asp Tyr Leu Thr Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Val Asp Thr Ala Ala Gln Ile Ser Glu 
    130                 135                 140                 


Gln Lys Ser Asn Asp Ala Ser Glu Ala Glu His Gln Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Asp Thr Cys Val Glu Trp Leu His Lys Tyr Leu Glu Lys Gly Lys 
                165                 170                 175     


Glu Thr Leu Leu His Leu Glu Pro Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Gln Asp Gly Glu Gly His 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro Val Thr Leu 
            260                 265                 270         


Arg Trp Lys Pro Ala Ser Gln Pro Thr Ile Pro Ile Val Gly Ile Ile 
        275                 280                 285             


Ala Gly Leu Val Leu Leu Gly Ser Val Val Ser Gly Ala Val Val Ala 
    290                 295                 300                 


Ala Val Ile Trp Arg Lys Lys Ser Ser Gly Gly Lys Gly Gly Ser Tyr 
305                 310                 315                 320 


Ser Lys Ala Glu Trp Ser Asp Ser Ala Gln Gly Ser Glu Ser His Ser 
                325                 330                 335     


Leu 
    


<210>  4
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2M/HLA-E*0101 fusion protein

<400>  4

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser His Ser Leu 
    130                 135                 140                 


Lys Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg 
145                 150                 155                 160 


Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp 
                165                 170                 175     


Asn Asp Ala Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu 
            180                 185                 190         


Gln Glu Gly Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp 
        195                 200                 205             


Thr Ala Gln Ile Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr 
    210                 215                 220                 


Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys 
225                 230                 235                 240 


Glu Leu Gly Pro Asp Arg Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala 
                245                 250                 255     


Tyr Asp Gly Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp 
            260                 265                 270         


Thr Ala Val Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp 
        275                 280                 285             


Ala Ser Glu Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val 
    290                 295                 300                 


Glu Trp Leu His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His 
305                 310                 315                 320 


Leu Glu Pro Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His 
                325                 330                 335     


Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile 
            340                 345                 350         


Thr Leu Thr Trp Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu 
        355                 360                 365             


Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala 
    370                 375                 380                 


Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val 
385                 390                 395                 400 


Gln His Glu Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala 
                405                 410                 415     


Ser Gln Pro Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu 
            420                 425                 430         


Leu Gly Ser Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg 
        435                 440                 445             


Lys Lys Ser Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp 
    450                 455                 460                 


Ser Asp Ser Ala Gln Gly Ser Glu Ser His Ser Leu 
465                 470                 475     


<210>  5
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2M/HLA-E*0103 fusion protein

<400>  5

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser His Ser Leu 
    130                 135                 140                 


Lys Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg 
145                 150                 155                 160 


Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp 
                165                 170                 175     


Asn Asp Ala Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu 
            180                 185                 190         


Gln Glu Gly Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp 
        195                 200                 205             


Thr Ala Gln Ile Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr 
    210                 215                 220                 


Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys 
225                 230                 235                 240 


Glu Leu Gly Pro Asp Gly Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala 
                245                 250                 255     


Tyr Asp Gly Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp 
            260                 265                 270         


Thr Ala Val Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp 
        275                 280                 285             


Ala Ser Glu Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val 
    290                 295                 300                 


Glu Trp Leu His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His 
305                 310                 315                 320 


Leu Glu Pro Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His 
                325                 330                 335     


Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile 
            340                 345                 350         


Thr Leu Thr Trp Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu 
        355                 360                 365             


Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala 
    370                 375                 380                 


Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val 
385                 390                 395                 400 


Gln His Glu Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala 
                405                 410                 415     


Ser Gln Pro Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu 
            420                 425                 430         


Leu Gly Ser Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg 
        435                 440                 445             


Lys Lys Ser Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp 
    450                 455                 460                 


Ser Asp Ser Ala Gln Gly Ser Glu Ser His Ser Leu 
465                 470                 475     


<210>  6
<211>  1428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M/HLA-E*0101 gene

<400>  6
atgtctcgct ccgtggcctt agctgtgctc gcgctactct ctctttctgg cctggaggct       60

atccagcgta ctccaaagat tcaggtttac tcacgtcatc cagcagagaa tggaaagtca      120

aatttcctga attgctatgt gtctgggttt catccatccg acattgaagt tgacttactg      180

aagaatggag agagaattga aaaagtggag cattcagact tgtctttcag caaggactgg      240

tctttctatc tcttgtacta cactgaattc acccccactg aaaaagatga gtatgcctgc      300

cgtgtgaacc atgtgacttt gtcacagccc aagatagtta agtgggatcg agacatgggt      360

ggtggcggtt ctggtggtgg cggtagtggc ggcggaggaa gcggtggtgg cggttccggt      420

tcccactcct tgaagtattt ccacacttcc gtgtcccggc ccggccgcgg ggagccccgc      480

ttcatctctg tgggctacgt ggacgacacc cagttcgtgc gcttcgacaa cgacgccgcg      540

agtccgagga tggtgccgcg ggcgccgtgg atggagcagg aggggtcaga gtattgggac      600

cgggagacac ggagcgccag ggacaccgca cagattttcc gagtgaacct gcggacgctg      660

cgcggctact acaatcagag cgaggccggt tctcacaccc tgcagtggat gcatggctgc      720

gagctggggc ccgacaggcg cttcctccgc gggtatgaac agttcgccta cgacggcaag      780

gattatctca ccctgaatga ggacctgcgc tcctggaccg cggtggacac ggcggctcag      840

atctccgagc aaaagtcaaa tgatgcctct gaggcggagc accagagagc ctacctggaa      900

gacacatgcg tggagtggct ccacaaatac ctggagaagg ggaaggagac gctgcttcac      960

ctggagcccc caaagacaca cgtgactcac caccccatct ctgaccatga ggccaccctg     1020

aggtgctggg ccctgggctt ctaccctgcg gagatcacac tgacctggca gcaggatggg     1080

gagggccata cccaggacac ggagctcgtg gagaccaggc ctgcagggga tggaaccttc     1140

cagaagtggg cagctgtggt ggtgccttct ggagaggagc agagatacac gtgccatgtg     1200

cagcatgagg ggctacccga gcccgtcacc ctgagatgga agccggcttc ccagcccacc     1260

atccccatcg tgggcatcat tgctggcctg gttctccttg gatctgtggt ctctggagct     1320

gtggttgctg ctgtgatatg gaggaagaag agctcaggtg ggaaaggagg gagctactct     1380

aaggctgagt ggagcgacag tgcccagggg tctgagtctc acagcttg                  1428


<210>  7
<211>  1428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M/HLA-E*0103 gene

<400>  7
atgtctcgct ccgtggcctt agctgtgctc gcgctactct ctctttctgg cctggaggct       60

atccagcgta ctccaaagat tcaggtttac tcacgtcatc cagcagagaa tggaaagtca      120

aatttcctga attgctatgt gtctgggttt catccatccg acattgaagt tgacttactg      180

aagaatggag agagaattga aaaagtggag cattcagact tgtctttcag caaggactgg      240

tctttctatc tcttgtacta cactgaattc acccccactg aaaaagatga gtatgcctgc      300

cgtgtgaacc atgtgacttt gtcacagccc aagatagtta agtgggatcg agacatgggt      360

ggtggcggtt ctggtggtgg cggtagtggc ggcggaggaa gcggtggtgg cggttccggt      420

tcccactcct tgaagtattt ccacacttcc gtgtcccggc ccggccgcgg ggagccccgc      480

ttcatctctg tgggctacgt ggacgacacc cagttcgtgc gcttcgacaa cgacgccgcg      540

agtccgagga tggtgccgcg ggcgccgtgg atggagcagg aggggtcaga gtattgggac      600

cgggagacac ggagcgccag ggacaccgca cagattttcc gagtgaacct gcggacgctg      660

cgcggctact acaatcagag cgaggccggt tctcacaccc tgcagtggat gcatggctgc      720

gagctggggc ccgacgggcg cttcctccgc gggtatgaac agttcgccta cgacggcaag      780

gattatctca ccctgaatga ggacctgcgc tcctggaccg cggtggacac ggcggctcag      840

atctccgagc aaaagtcaaa tgatgcctct gaggcggagc accagagagc ctacctggaa      900

gacacatgcg tggagtggct ccacaaatac ctggagaagg ggaaggagac gctgcttcac      960

ctggagcccc caaagacaca cgtgactcac caccccatct ctgaccatga ggccaccctg     1020

aggtgctggg ccctgggctt ctaccctgcg gagatcacac tgacctggca gcaggatggg     1080

gagggccata cccaggacac ggagctcgtg gagaccaggc ctgcagggga tggaaccttc     1140

cagaagtggg cagctgtggt ggtgccttct ggagaggagc agagatacac gtgccatgtg     1200

cagcatgagg ggctacccga gcccgtcacc ctgagatgga agccggcttc ccagcccacc     1260

atccccatcg tgggcatcat tgctggcctg gttctccttg gatctgtggt ctctggagct     1320

gtggttgctg ctgtgatatg gaggaagaag agctcaggtg ggaaaggagg gagctactct     1380

aaggctgagt ggagcgacag tgcccagggg tctgagtctc acagcttg                  1428


<210>  8
<211>  376
<212>  PRT
<213>  herpes simplex virus

<400>  8

Met Ala Ser Tyr Pro Gly His Gln His Ala Ser Ala Phe Asp Gln Ala 
1               5                   10                  15      


Ala Arg Ser Arg Gly His Ser Asn Arg Arg Thr Ala Leu Arg Pro Arg 
            20                  25                  30          


Arg Gln Gln Glu Ala Thr Glu Val Arg Pro Glu Gln Lys Met Pro Thr 
        35                  40                  45              


Leu Leu Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr 
    50                  55                  60                  


Thr Thr Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr 
65                  70                  75                  80  


Val Pro Glu Pro Met Thr Tyr Trp Arg Val Leu Gly Ala Ser Glu Thr 
                85                  90                  95      


Ile Ala Asn Ile Tyr Thr Thr Gln His Arg Leu Asp Gln Gly Glu Ile 
            100                 105                 110         


Ser Ala Gly Asp Ala Ala Val Val Met Thr Ser Ala Gln Ile Thr Met 
        115                 120                 125             


Gly Met Pro Tyr Ala Val Thr Asp Ala Val Leu Ala Pro His Ile Gly 
    130                 135                 140                 


Gly Glu Ala Gly Ser Ser His Ala Pro Pro Pro Ala Leu Thr Leu Ile 
145                 150                 155                 160 


Phe Asp Arg His Pro Ile Ala Ala Leu Leu Cys Tyr Pro Ala Ala Arg 
                165                 170                 175     


Tyr Leu Met Gly Ser Met Thr Pro Gln Ala Val Leu Ala Phe Val Ala 
            180                 185                 190         


Leu Ile Pro Pro Thr Leu Pro Gly Thr Asn Ile Val Leu Gly Ala Leu 
        195                 200                 205             


Pro Glu Asp Arg His Ile Asp Arg Leu Ala Lys Arg Gln Arg Pro Gly 
    210                 215                 220                 


Glu Arg Leu Asp Leu Ala Met Leu Ala Ala Ile Arg Arg Val Tyr Gly 
225                 230                 235                 240 


Leu Leu Ala Asn Thr Val Arg Tyr Leu Gln Cys Gly Gly Ser Trp Arg 
                245                 250                 255     


Glu Asp Trp Gly Gln Leu Ser Gly Thr Ala Val Pro Pro Gln Gly Ala 
            260                 265                 270         


Glu Pro Gln Ser Asn Ala Gly Pro Arg Pro His Ile Gly Asp Thr Leu 
        275                 280                 285             


Phe Thr Leu Phe Arg Ala Pro Glu Leu Leu Ala Pro Asn Gly Asp Leu 
    290                 295                 300                 


Tyr Asn Val Phe Ala Trp Ala Leu Asp Val Leu Ala Lys Arg Leu Arg 
305                 310                 315                 320 


Ser Met His Val Phe Ile Leu Asp Tyr Asp Gln Ser Pro Ala Gly Cys 
                325                 330                 335     


Arg Asp Ala Leu Leu Gln Leu Thr Ser Gly Met Val Gln Thr His Val 
            340                 345                 350         


Thr Thr Pro Gly Ser Ile Pro Thr Ile Cys Asp Leu Ala Arg Thr Phe 
        355                 360                 365             


Ala Arg Glu Met Gly Glu Ala Asn 
    370                 375     


<210>  9
<211>  1128
<212>  DNA
<213>  herpes simplex virus

<400>  9
atggcttctt accctggaca ccagcatgct tctgcctttg accaggctgc cagatccagg       60

ggccactcca acaggagaac tgccctaaga cccagaagac agcaggaagc cactgaggtg      120

aggcctgagc agaagatgcc aaccctgctg agggtgtaca ttgatggacc tcatggcatg      180

ggcaagacca ccaccactca actgctggtg gcactgggct ccagggatga cattgtgtat      240

gtgcctgagc caatgaccta ctggagagtg ctaggagcct ctgagaccat tgccaacatc      300

tacaccaccc agcacaggct ggaccaggga gaaatctctg ctggagatgc tgctgtggtg      360

atgacctctg cccagatcac aatgggaatg ccctatgctg tgactgatgc tgttctggct      420

cctcacattg gaggagaggc tggctcttct catgcccctc cacctgccct gaccctgatc      480

tttgacagac accccattgc agccctgctg tgctacccag cagcaaggta cctcatgggc      540

tccatgaccc cacaggctgt gctggctttt gtggccctga tccctccaac cctccctggc      600

accaacattg ttctgggagc actgcctgaa gacagacaca ttgacaggct ggcaaagagg      660

cagagacctg gagagagact ggacctggcc atgctggctg caatcagaag ggtgtatgga      720

ctgctggcaa acactgtgag atacctccag tgtggaggct cttggagaga ggactgggga      780

cagctctctg gaacagcagt gccccctcaa ggagctgagc cccagtccaa tgctggtcca      840

agaccccaca ttggggacac cctgttcacc ctgttcagag cccctgagct gctggctccc      900

aatggagacc tgtacaatgt gtttgcctgg gctctggatg ttctagccaa gaggctgagg      960

tccatgcatg tgttcatcct ggactatgac cagtcccctg ctggatgcag agatgctctg     1020

ctgcaactaa cctctggcat ggtgcagacc catgtgacca cccctggcag catccccacc     1080

atctgtgacc tagccagaac ctttgccagg gagatgggag aggccaac                  1128


<210>  10
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TK-sr39 enzyme

<400>  10

Met Ala Ser Tyr Pro Gly His Gln His Ala Ser Ala Phe Asp Gln Ala 
1               5                   10                  15      


Ala Arg Ser Arg Gly His Ser Asn Arg Arg Thr Ala Leu Arg Pro Arg 
            20                  25                  30          


Arg Gln Gln Glu Ala Thr Glu Val Arg Pro Glu Gln Lys Met Pro Thr 
        35                  40                  45              


Leu Leu Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr 
    50                  55                  60                  


Thr Thr Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr 
65                  70                  75                  80  


Val Pro Glu Pro Met Thr Tyr Trp Arg Val Leu Gly Ala Ser Glu Thr 
                85                  90                  95      


Ile Ala Asn Ile Tyr Thr Thr Gln His Arg Leu Asp Gln Gly Glu Ile 
            100                 105                 110         


Ser Ala Gly Asp Ala Ala Val Val Met Thr Ser Ala Gln Ile Thr Met 
        115                 120                 125             


Gly Met Pro Tyr Ala Val Thr Asp Ala Val Leu Ala Pro His Ile Gly 
    130                 135                 140                 


Gly Glu Ala Gly Ser Ser His Ala Pro Pro Pro Ala Leu Thr Ile Phe 
145                 150                 155                 160 


Leu Asp Arg His Pro Ile Ala Phe Met Leu Cys Tyr Pro Ala Ala Arg 
                165                 170                 175     


Tyr Leu Met Gly Ser Met Thr Pro Gln Ala Val Leu Ala Phe Val Ala 
            180                 185                 190         


Leu Ile Pro Pro Thr Leu Pro Gly Thr Asn Ile Val Leu Gly Ala Leu 
        195                 200                 205             


Pro Glu Asp Arg His Ile Asp Arg Leu Ala Lys Arg Gln Arg Pro Gly 
    210                 215                 220                 


Glu Arg Leu Asp Leu Ala Met Leu Ala Ala Ile Arg Arg Val Tyr Gly 
225                 230                 235                 240 


Leu Leu Ala Asn Thr Val Arg Tyr Leu Gln Cys Gly Gly Ser Trp Arg 
                245                 250                 255     


Glu Asp Trp Gly Gln Leu Ser Gly Thr Ala Val Pro Pro Gln Gly Ala 
            260                 265                 270         


Glu Pro Gln Ser Asn Ala Gly Pro Arg Pro His Ile Gly Asp Thr Leu 
        275                 280                 285             


Phe Thr Leu Phe Arg Ala Pro Glu Leu Leu Ala Pro Asn Gly Asp Leu 
    290                 295                 300                 


Tyr Asn Val Phe Ala Trp Ala Leu Asp Val Leu Ala Lys Arg Leu Arg 
305                 310                 315                 320 


Ser Met His Val Phe Ile Leu Asp Tyr Asp Gln Ser Pro Ala Gly Cys 
                325                 330                 335     


Arg Asp Ala Leu Leu Gln Leu Thr Ser Gly Met Val Gln Thr His Val 
            340                 345                 350         


Thr Thr Pro Gly Ser Ile Pro Thr Ile Cys Asp Leu Ala Arg Thr Phe 
        355                 360                 365             


Ala Arg Glu Met Gly Glu Ala Asn 
    370                 375     


<210>  11
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward target sequence

<400>  11
ctgtcccctc caccccac                                                     18


<210>  12
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse target sequence

<400>  12
ttctgtcacc aatcctgt                                                     18


<210>  13
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward target sequence

<400>  13
ctcaagtagg tctctttc                                                     18


<210>  14
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse target sequence

<400>  14
gaaagtcttc tcctccaa                                                     18


<210>  15
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward taregt sequence

<400>  15
tctcgctccg tggcctt                                                      17


<210>  16
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse target sequence

<400>  16
agcctccagg ccagaaag                                                     18


<210>  17
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward target sequence

<400>  17
ctgtcccctc caccccac                                                     18


<210>  18
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse target sequence

<400>  18
ttctgtcacc aatcctgt                                                     18


<210>  19
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward target sequence

<400>  19
ctcaagtagg tctctttc                                                     18


<210>  20
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse target sequence

<400>  20
gaaagtcttc tcctccaa                                                     18


<210>  21
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward target sequence

<400>  21
tctcgctccg tggcctt                                                      17


<210>  22
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse target sequence

<400>  22
agcctccagg ccagaaag                                                     18


