                         SEQUENCE LISTING

<110>  F. Hoffmann-La Roche AG
       Hoffmann-La Roche Inc.
 
<120>  ANTISENSE OLIGONUCLEOTIDES FOR TARGETING PROGRANULIN

<130>  P121460PCT

<150>  EP 20215791.3
<151>  2020-12-18

<160>  292   

<170>  PatentIn version 3.5

<210>  1
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  1
tgcgtccgac tccgcg                                                       16


<210>  2
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  2
gtccgactcc gcggtc                                                       16


<210>  3
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  3
cgactccgcg gtcctt                                                       16


<210>  4
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  4
ctccgcggtc cttggg                                                       16


<210>  5
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  5
cgcggtcctt gggcag                                                       16


<210>  6
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  6
ggtccttggg cagcag                                                       16


<210>  7
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  7
ccttgggcag cagcaa                                                       16


<210>  8
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  8
tgggcagcag caaccg                                                       16


<210>  9
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  9
gcagcagcaa ccgggt                                                       16


<210>  10
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  10
gcagcaaccg ggtagc                                                       16


<210>  11
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  11
gcaaccgggt agcgct                                                       16


<210>  12
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  12
accgggtagc gctcag                                                       16


<210>  13
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  13
gggtagcgct cagact                                                       16


<210>  14
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  14
tagcgctcag actaca                                                       16


<210>  15
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  15
cgctcagact acagac                                                       16


<210>  16
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  16
tcagactaca gacccc                                                       16


<210>  17
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  17
gactacagac cccagc                                                       16


<210>  18
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  18
tacagacccc agcgcg                                                       16


<210>  19
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  19
agtccctact accttc                                                       16


<210>  20
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  20
ccctactacc ttcgag                                                       16


<210>  21
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  21
tactaccttc gagaag                                                       16


<210>  22
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  22
taccttcgag aagcca                                                       16


<210>  23
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  23
cttcgagaag ccaagg                                                       16


<210>  24
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  24
cgagaagcca aggtct                                                       16


<210>  25
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  25
gaagccaagg tctcag                                                       16


<210>  26
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  26
gccaaggtct caggtc                                                       16


<210>  27
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  27
aaggtctcag gtctcg                                                       16


<210>  28
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  28
gtctcaggtc tcgttc                                                       16


<210>  29
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  29
tcaggtctcg ttccca                                                       16


<210>  30
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  30
ggtctcgttc ccaggc                                                       16


<210>  31
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  31
ctcgttccca ggccct                                                       16


<210>  32
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  32
gttcccaggc cctcgg                                                       16


<210>  33
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  33
cccaggccct cggagc                                                       16


<210>  34
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  34
aggccctcgg agctcc                                                       16


<210>  35
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  35
ccctcggagc tcccag                                                       16


<210>  36
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  36
tcggagctcc cagccc                                                       16


<210>  37
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  37
gagctcccag cccagg                                                       16


<210>  38
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  38
ctcccagccc agggtc                                                       16


<210>  39
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  39
ccagcccagg gtcgcg                                                       16


<210>  40
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  40
gcccagggtc gcgcgc                                                       16


<210>  41
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  41
cagggtcgcg cgcccc                                                       16


<210>  42
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  42
ggtcgcgcgc ccctcc                                                       16


<210>  43
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  43
cgcgcgcccc tccggc                                                       16


<210>  44
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  44
gcgcccctcc ggctcc                                                       16


<210>  45
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  45
cccctccggc tccagg                                                       16


<210>  46
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  46
ctccggctcc aggccg                                                       16


<210>  47
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  47
cggctccagg ccgccg                                                       16


<210>  48
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  48
ctccaggccg ccgcgg                                                       16


<210>  49
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  49
caggccgccg cgggaa                                                       16


<210>  50
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  50
gccgcgggaa ccaccc                                                       16


<210>  51
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  51
gcgggaacca cccacc                                                       16


<210>  52
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  52
ggaaccaccc accacc                                                       16


<210>  53
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  53
accacccacc accacc                                                       16


<210>  54
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  54
acccaccacc accagg                                                       16


<210>  55
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  55
caccaccacc aggaga                                                       16


<210>  56
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  56
caccaccagg agaggg                                                       16


<210>  57
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  57
caccaggaga ggggaa                                                       16


<210>  58
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  58
caggagaggg gaagaa                                                       16


<210>  59
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  59
gagaggggaa gaagcc                                                       16


<210>  60
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  60
aggggaagaa gccagc                                                       16


<210>  61
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  61
ggaagaagcc agcacc                                                       16


<210>  62
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  62
agaagccagc acctac                                                       16


<210>  63
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  63
agccagcacc taccga                                                       16


<210>  64
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  64
cagcacctac cgacag                                                       16


<210>  65
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  65
cacctaccga cagggg                                                       16


<210>  66
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  66
ctaccgacag gggtgg                                                       16


<210>  67
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  67
ccgacagggg tggagc                                                       16


<210>  68
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  68
acaggggtgg agctgg                                                       16


<210>  69
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  69
ggggtggagc tgggtc                                                       16


<210>  70
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  70
gtggagctgg gtcaag                                                       16


<210>  71
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  71
gagctgggtc aagaat                                                       16


<210>  72
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  72
ctgggtcaag aatggt                                                       16


<210>  73
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  73
ggtcaagaat ggtgtg                                                       16


<210>  74
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  74
caagaatggt gtggtc                                                       16


<210>  75
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  75
gaatggtgtg gtccct                                                       16


<210>  76
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  76
tggtgtggtc cctgct                                                       16


<210>  77
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  77
tgtggtccct gctttg                                                       16


<210>  78
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  78
ggtccctgct ttgggg                                                       16


<210>  79
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  79
ccctgctttg ggggaa                                                       16


<210>  80
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  80
tgctttgggg gaatgc                                                       16


<210>  81
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  81
tttgggggaa tgctgg                                                       16


<210>  82
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  82
gggggaatgc tgggga                                                       16


<210>  83
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  83
ggaatgctgg ggaggt                                                       16


<210>  84
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  84
atgctgggga ggtaga                                                       16


<210>  85
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  85
ctggggaggt agaaag                                                       16


<210>  86
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  86
gggaggtaga aagccc                                                       16


<210>  87
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  87
aggtagaaag cccctt                                                       16


<210>  88
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  88
tagaaagccc cttcta                                                       16


<210>  89
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  89
aaagcccctt ctaacg                                                       16


<210>  90
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  90
gccccttcta acgggg                                                       16


<210>  91
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  91
ccttctaacg gggcgt                                                       16


<210>  92
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  92
tctaacgggg cgtcac                                                       16


<210>  93
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  93
aacggggcgt cactgc                                                       16


<210>  94
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  94
ggggcgtcac tgcaat                                                       16


<210>  95
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  95
gcgtcactgc aattac                                                       16


<210>  96
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  96
tcactgcaat tactgc                                                       16


<210>  97
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  97
ctgcaattac tgcttc                                                       16


<210>  98
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  98
caattactgc ttcctc                                                       16


<210>  99
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  99
ttactgcttc ctcttt                                                       16


<210>  100
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  100
ctgcttcctc tttccc                                                       16


<210>  101
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  101
cttcctcttt cccata                                                       16


<210>  102
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  102
cctctttccc ataaaa                                                       16


<210>  103
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  103
ctttcccata aaactc                                                       16


<210>  104
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  104
tcccataaaa ctcccc                                                       16


<210>  105
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  105
cataaaactc ccccta                                                       16


<210>  106
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  106
aaaactcccc ctagtg                                                       16


<210>  107
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  107
actcccccta gtgtat                                                       16


<210>  108
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  108
ccccctagtg tatcag                                                       16


<210>  109
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  109
cctagtgtat cagaac                                                       16


<210>  110
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  110
agtgtatcag aacccc                                                       16


<210>  111
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  111
gtatcagaac ccccaa                                                       16


<210>  112
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  112
tcagaacccc caagga                                                       16


<210>  113
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  113
gaacccccaa ggagtt                                                       16


<210>  114
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  114
cccccaagga gtttca                                                       16


<210>  115
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  115
ccaaggagtt tcagta                                                       16


<210>  116
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  116
aggagtttca gtaagc                                                       16


<210>  117
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  117
agtttcagta agcggt                                                       16


<210>  118
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  118
ttcagtaagc ggttct                                                       16


<210>  119
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  119
agtaagcggt tcttct                                                       16


<210>  120
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  120
aagcggttct tctgtt                                                       16


<210>  121
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  121
cggttcttct gttgtc                                                       16


<210>  122
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  122
ttcttctgtt gtctcc                                                       16


<210>  123
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  123
ttctgttgtc tccggc                                                       16


<210>  124
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  124
tgttgtctcc ggctga                                                       16


<210>  125
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  125
tgtctccggc tgagac                                                       16


<210>  126
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  126
ctccggctga gactcc                                                       16


<210>  127
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  127
cggctgagac tccagg                                                       16


<210>  128
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  128
ctgagactcc agggga                                                       16


<210>  129
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  129
agactccagg ggaacc                                                       16


<210>  130
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  130
ctccagggga acctca                                                       16


<210>  131
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  131
caggggaacc tcaagc                                                       16


<210>  132
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  132
gggaacctca agctca                                                       16


<210>  133
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  133
aacctcaagc tcacat                                                       16


<210>  134
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  134
ctcaagctca catggc                                                       16


<210>  135
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  135
aagctcacat ggccct                                                       16


<210>  136
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  136
ctcacatggc cctggc                                                       16


<210>  137
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  137
acatggccct ggcggg                                                       16


<210>  138
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  138
tggccctggc gggccc                                                       16


<210>  139
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  139
ccctggcggg cccctg                                                       16


<210>  140
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  140
tggcgggccc ctgggc                                                       16


<210>  141
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  141
cgggcccctg ggcagg                                                       16


<210>  142
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  142
gcccctgggc aggagc                                                       16


<210>  143
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  143
cctgggcagg agcagg                                                       16


<210>  144
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  144
gggcaggagc aggcga                                                       16


<210>  145
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  145
caggagcagg cgagag                                                       16


<210>  146
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  146
gagcaggcga gaggtc                                                       16


<210>  147
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  147
caggcgagag gtctgc                                                       16


<210>  148
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  148
gcgagaggtc tgcgcg                                                       16


<210>  149
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  149
agaggtctgc gcggcc                                                       16


<210>  150
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  150
ggtctgcgcg gccgct                                                       16


<210>  151
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  151
ctgcgcggcc gctctc                                                       16


<210>  152
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  152
cgcggccgct ctccta                                                       16


<210>  153
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  153
ggccgctctc ctacct                                                       16


<210>  154
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  154
cgctctccta cctgcg                                                       16


<210>  155
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  155
tctcctacct gcgtcc                                                       16


<210>  156
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  156
cctacctgcg tccgac                                                       16


<210>  157
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  157
acctgcgtcc gactcc                                                       16


<210>  158
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  158
ggggaagaag ccagca                                                       16


<210>  159
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  159
gggaagaagc cagcac                                                       16


<210>  160
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  160
gaagaagcca gcacct                                                       16


<210>  161
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  161
aagaagccag caccta                                                       16


<210>  162
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  162
gaagccagca cctacc                                                       16


<210>  163
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  163
aagccagcac ctaccg                                                       16


<210>  164
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  164
gccagcacct accgac                                                       16


<210>  165
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  165
ccagcaccta ccgaca                                                       16


<210>  166
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  166
agcacctacc gacagg                                                       16


<210>  167
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  167
gcacctaccg acaggg                                                       16


<210>  168
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  168
acctaccgac aggggt                                                       16


<210>  169
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  169
cctaccgaca ggggtg                                                       16


<210>  170
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  170
taccgacagg ggtgga                                                       16


<210>  171
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  171
accgacaggg gtggag                                                       16


<210>  172
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  172
cgacaggggt ggagct                                                       16


<210>  173
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  173
gacaggggtg gagctg                                                       16


<210>  174
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  174
caggggtgga gctggg                                                       16


<210>  175
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  175
aggggtggag ctgggt                                                       16


<210>  176
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  176
gggtggagct gggtca                                                       16


<210>  177
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  177
ggtggagctg ggtcaa                                                       16


<210>  178
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  178
tggagctggg tcaaga                                                       16


<210>  179
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  179
ggagctgggt caagaa                                                       16


<210>  180
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  180
cagaagggga cggcag                                                       16


<210>  181
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  181
aaggggacgg cagcag                                                       16


<210>  182
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  182
gggacggcag cagctg                                                       16


<210>  183
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  183
acggcagcag ctgtag                                                       16


<210>  184
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  184
gcagcagctg tagctg                                                       16


<210>  185
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  185
gcagctgtag ctggct                                                       16


<210>  186
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  186
gctgtagctg gctcct                                                       16


<210>  187
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  187
gtagctggct cctccg                                                       16


<210>  188
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  188
gctggctcct ccgggg                                                       16


<210>  189
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  189
ggctcctccg gggtcc                                                       16


<210>  190
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  190
tcctccgggg tccagg                                                       16


<210>  191
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  191
tccggggtcc aggcag                                                       16


<210>  192
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  192
ggggtccagg cagcag                                                       16


<210>  193
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  193
gtccaggcag caggcc                                                       16


<210>  194
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  194
caggcagcag gccaca                                                       16


<210>  195
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  195
gcagcaggcc acaggg                                                       16


<210>  196
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  196
gcaggccaca gggcag                                                       16


<210>  197
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  197
ggccacaggg cagaac                                                       16


<210>  198
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  198
cacagggcag aactga                                                       16


<210>  199
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  199
agggcagaac tgacca                                                       16


<210>  200
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  200
gcagaactga ccatct                                                       16


<210>  201
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  201
gaactgacca tctggg                                                       16


<210>  202
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  202
ctgaccatct gggcac                                                       16


<210>  203
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  203
accatctggg caccgc                                                       16


<210>  204
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  204
atctgggcac cgcgtt                                                       16


<210>  205
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  205
tgggcaccgc gttcca                                                       16


<210>  206
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  206
gcaccgcgtt ccagcc                                                       16


<210>  207
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  207
ccgcgttcca gccacc                                                       16


<210>  208
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  208
cgttccagcc accagc                                                       16


<210>  209
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  209
tccagccacc agccct                                                       16


<210>  210
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  210
agccaccagc cctgct                                                       16


<210>  211
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  211
caccagccct gctgtt                                                       16


<210>  212
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  212
cagccctgct gttaag                                                       16


<210>  213
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  213
ccctgctgtt aaggcc                                                       16


<210>  214
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  214
tgctgttaag gccacc                                                       16


<210>  215
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  215
tgttaaggcc acccag                                                       16


<210>  216
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  216
taaggccacc cagctc                                                       16


<210>  217
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  217
ggccacccag ctcacc                                                       16


<210>  218
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  218
cacccagctc accagg                                                       16


<210>  219
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  219
ccagctcacc agggtc                                                       16


<210>  220
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  220
gctcaccagg gtccac                                                       16


<210>  221
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  221
caccagggtc cacatg                                                       16


<210>  222
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  222
cagggtccac atggtc                                                       16


<210>  223
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  223
ggtccacatg gtctgc                                                       16


<210>  224
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  224
ccacatggtc tgcctg                                                       16


<210>  225
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  225
catggtctgc ctgcaa                                                       16


<210>  226
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  226
ggtctgcctg caaagt                                                       16


<210>  227
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  227
ctgcctgcaa agtacc                                                       16


<210>  228
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  228
cctgcaaagt accaag                                                       16


<210>  229
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  229
gcaaagtacc aaggaa                                                       16


<210>  230
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  230
aagtaccaag gaacgt                                                       16


<210>  231
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  231
taccaaggaa cgtctg                                                       16


<210>  232
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  232
caaggaacgt ctggca                                                       16


<210>  233
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  233
ggaacgtctg gcaact                                                       16


<210>  234
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  234
acgtctggca actgct                                                       16


<210>  235
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  235
tctggcaact gcttaa                                                       16


<210>  236
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  236
ggcaactgct taagcc                                                       16


<210>  237
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  237
aactgcttaa gcccac                                                       16


<210>  238
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  238
tgcttaagcc cacgcc                                                       16


<210>  239
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  239
ttaagcccac gccacc                                                       16


<210>  240
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  240
agcccacgcc accctt                                                       16


<210>  241
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  241
ccacgccacc cttgat                                                       16


<210>  242
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  242
cgccaccctt gattct                                                       16


<210>  243
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  243
cacccttgat tctagg                                                       16


<210>  244
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  244
ccttgattct agggtc                                                       16


<210>  245
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  245
tgattctagg gtcact                                                       16


<210>  246
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  246
ttctagggtc actcag                                                       16


<210>  247
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  247
tagggtcact cagtac                                                       16


<210>  248
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  248
ggtcactcag taccct                                                       16


<210>  249
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  249
cactcagtac cctagc                                                       16


<210>  250
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  250
tcagtaccct agcccc                                                       16


<210>  251
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  251
gtaccctagc cccagg                                                       16


<210>  252
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  252
ccctagcccc aggcca                                                       16


<210>  253
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  253
tagccccagg ccaagg                                                       16


<210>  254
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  254
ccccaggcca aggtcc                                                       16


<210>  255
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  255
caggccaagg tcctgg                                                       16


<210>  256
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  256
gccaaggtcc tggccc                                                       16


<210>  257
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  257
aaggtcctgg cccagg                                                       16


<210>  258
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  258
gtcctggccc aggact                                                       16


<210>  259
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  259
ctggcccagg actgcc                                                       16


<210>  260
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  260
gcccaggact gcctga                                                       16


<210>  261
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  261
caggactgcc tgagcc                                                       16


<210>  262
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  262
gactgcctga gccttc                                                       16


<210>  263
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  263
tgcctgagcc ttctca                                                       16


<210>  264
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  264
ctgagccttc tcaaca                                                       16


<210>  265
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  265
agccttctca acacct                                                       16


<210>  266
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  266
cttctcaaca cctccc                                                       16


<210>  267
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  267
ctcaacacct ccctgt                                                       16


<210>  268
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  268
aacacctccc tgtcca                                                       16


<210>  269
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  269
acctccctgt ccaggc                                                       16


<210>  270
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  270
tccctgtcca ggcagg                                                       16


<210>  271
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  271
ctgtccaggc aggcag                                                       16


<210>  272
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  272
tccaggcagg cagaaa                                                       16


<210>  273
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  273
aggcaggcag aaatct                                                       16


<210>  274
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  274
caggcagaaa tctgca                                                       16


<210>  275
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  275
gcagaaatct gcaggg                                                       16


<210>  276
<211>  4180
<212>  DNA
<213>  Homo sapiens

<400>  276
ggcgagagga agcagggagg agagtgattt gagtagaaaa gaaacacagc attccaggct       60

ggccccacct ctatattgat aagtagccaa tgggagcggg tagccctgat ccctggccaa      120

tggaaactga ggtaggcggg tcatcgcgct ggggtctgta gtctgagcgc tacccggttg      180

ctgctgccca aggaccgcgg agtcggacgc aggtaggaga gcggccgcgc agacctctcg      240

cctgctcctg cccaggggcc cgccagggcc atgtgagctt gaggttcccc tggagtctca      300

gccggagaca acagaagaac cgcttactga aactccttgg gggttctgat acactagggg      360

gagttttatg ggaaagagga agcagtaatt gcagtgacgc cccgttagaa ggggctttct      420

acctccccag cattccccca aagcagggac cacaccattc ttgacccagc tccacccctg      480

tcggtaggtg ctggcttctt cccctctcct ggtggtggtg ggtggttccc gcggcggcct      540

ggagccggag gggcgcgcga ccctgggctg ggagctccga gggcctggga acgagacctg      600

agaccttggc ttctcgaagg tagtagggac ttgggagtgg tgactgaacc tggtctggct      660

cctccttact tcctcttgtt gcgggtggga cgagctagct tccgcctctc ccagccactt      720

tttcctgctc atttgcagct aggttggctc cccttttggg aatttcctct ccccttggca      780

ctcggagttg gggggtgcca cctagtggaa gataacggag ctagggtctt gaagaggctg      840

ctgtcccctc tggctgtttt ggcggtgtag ggtggcatga gagactgcga ctcgcctcct      900

catccctgtt tctgtatgcg agtgcttgta ttcagtagaa gcatacacta tactccctca      960

atttagggta aacaggaggg gccacatgca caggtaattc accagggagc cgaacactcc     1020

tgtgcagaca gactcccctt cccagcaagc catggcagcg gacagcctgc tgagaacacc     1080

caggaagcag gcggtgccag ctgcaggtgc tttgcctggg agctgtgggg ctgaggagag     1140

ggtccactgt ccaggaccag tgaacttcat ccttatctgt ccaggaggtg gcctcttggg     1200

gatgctgagt taggggaggg gcacttgagg aaagccaggt ggagcagaga ggatgtgagt     1260

gactgggtgg gtgagatttc ctgcccctcc ccccgcagtg gtatccacac ctagactcgt     1320

ggggtaactg aggcacagac agagagcaac ttctcaggcc ctcacagttg gcaattctag     1380

gattaggacc caagtgcgat tttcaggcag tccctgtacc ctgtttctgt tgtacctgtt     1440

gcaccattcc caggcactgc ccatcgtgcc actagtgata tgaacccagg tccaatacgc     1500

tctggggcca tcaaagcctg acgtcaccat gacctgatgt gtgacgtgtt ataggtgtcc     1560

cttggtatct tcacggaact ggttccagga ccccaaaatc tgtgggtgct caagcccctg     1620

agataaaatg gtgtaatatt tgcatataac ctatacatac tttaaatcat ttctagatta     1680

cttataccta atacaatgga aatgacatgt cggctgggcg tggtggctca tgcctgtaat     1740

cccaccactt tgggaggccg tggcaggtgg atcacctgag gtctggagtt tgagaccagc     1800

ctgaccaaca tggtgaaacc cccatctcta ctaaaaatac aaaaattagc caggtgtggt     1860

agcgcacacc tataatccca cctacttggg aggctgaggc aggagaattg cttgaacctg     1920

ggaggcggag ttcgcagtaa gctgagatcg cgccactgta ctacagcctg ggtgacagag     1980

caggactcca tctcaaaaaa aaaagagaaa aagaaaaaga aatgccatgt aaatagttgt     2040

gatcctgaat tgtttaggga ataataagaa agaactatct gtagatgttc agtatagatg     2100

cacccatcgt aagcctaact acattgtata actcagcaac gatgtaacat tttcaggggt     2160

ttttttgttt tgttttttga gacagaatct cagtctcact ctgtcaccca ggctggagta     2220

tgttggcgtg atctctgctc actgcaacct ccacctcctg ggctcaagcg attctcctgc     2280

ctcagcctct tgagtagctg ggattgcagg tgtgcgctac cacgcatggc taatttttgt     2340

atttttaata gagatggggt tttaccacgt tggtcaggct ggtcttgaac tcctgacctt     2400

gggatccgcc cacctgggcc tcccaaagtg ctgggattac aggcgttagc caccgcgccc     2460

aatatatttt gatccctggt tggatatgga gggctgactg tacttaacat ctctaagctt     2520

cagtttcctc ctttaaaata aaggtgtggc tgggtgtggt ggttcaagcc tgtaatccca     2580

gcacttaggg aggctgaggt gggtggatca gctgaggtca ggagttcaag accagcctga     2640

ccaatatggt gaaaccccct ctctgctaaa aatacaaaaa ttagccaggc gtggtggcga     2700

gcgcctgtag tcccagctac ttgcttgaac ttgggaggca gaggttgcag tgagctgaga     2760

tcgtgccact gaactcgagc atgggcaaca gagcaagact gtctcaaaaa aaaaaaaaaa     2820

aagggggtga gcagacgtgg tggcacgctc ccacagtccc agctacttag taggaggcca     2880

aggttggagg attgcttgat cccaggagtc tgagtccagc ctgggcaaca tggcaatacc     2940

tcatctctaa aaataaaata aaagtaaagg tattaattac tactttggat ggttgttgca     3000

aagaaatata tataaaataa tggagagtct tgtaactggc tcccaagagg ctcaacagac     3060

attactgttt ttgcttcttc attatgagtt acctctctgg ccaccccact gaactagctg     3120

ggctagctga gcctgggaga agagttgttt aggaagtgag aggctgctct ccacagagac     3180

tcaaggctca gttcctcctg gtgactcaga tgggcagccc agtgggcaca cgtggtctct     3240

ctccacatgt ggctgagttt cacttccaga atagatggag aggcaagggc agggtttagc     3300

atgcttgagg aatctcagag ggccctggtg gtgtggggga ccctcagaac acaggtgtct     3360

caagggctga cccagcttct gtgtcctttt ctctgggtga ggaggggaca ttcatgggca     3420

gatggtgacc tctggggaag gcagcccaga ctccactggc caccatattt cctttttcac     3480

aactttctca cccctgtggt ttcccatgtc atcatgtggc cgcttcccgc aaggccttag     3540

cggggtgcag gtatgaacat agtgtcaggc aaggaggcat ctggagggga accctggctt     3600

ttcctggggg gactccctcc ctgcacccta gccctgtcct ctcccatggc tactgatgcc     3660

ttcccctcac cccagaggtg gcccacatct gcacagatca gacccacaaa aatcacgtct     3720

tcctgactct cataagcctg cccagtgagg cccaggcatt aggccatgtg ctggggactc     3780

agacccacac atatacgcat gtcagcattc atgcttacag gtccgcacat gctggggcaa     3840

gtgtcacaca cggggcgctg taggaagctg actctcagcc cctgcagatt tctgcctgcc     3900

tggacaggga ggtgttgaga aggctcaggc agtcctgggc caggaccttg gcctggggct     3960

agggtactga gtgaccctag aatcaagggt ggcgtgggct taagcagttg ccagacgttc     4020

cttggtactt tgcaggcaga ccatgtggac cctggtgagc tgggtggcct taacagcagg     4080

gctggtggct ggaacgcggt gcccagatgg tcagttctgc cctgtggcct gctgcctgga     4140

ccccggagga gccagctaca gctgctgccg tccccttctg                           4180


<210>  277
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target site for SEQ ID NO: 71

<400>  277
attcttgacc cagctc                                                       16


<210>  278
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target site for SEQ ID NO: 73

<400>  278
cacaccattc ttgacc                                                       16


<210>  279
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target site for SEQ ID NO: 74

<400>  279
gaccacacca ttcttg                                                       16


<210>  280
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target site for SEQ ID NO: 75

<400>  280
agggaccaca ccattc                                                       16


<210>  281
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target site for SEQ ID NO: 134

<400>  281
gccatgtgag cttgag                                                       16


<210>  282
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GRN Exon1-Exon2 (FAM) Primer 1

<400>  282
gctgctgccc aaggaccgcg ga                                                22


<210>  283
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GRN Exon1-Exon2 (FAM) Primer 2

<400>  283
gccctgctgt taaggccacc ca                                                22


<210>  284
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GRN Exon1-Exon2 (FAM) Probe


<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  internal ZEN quencher between nucleotides 9 and 10

<400>  284
ggacgcaggc agaccatgtg gaccctg                                           27


<210>  285
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GRN Intron1-Exon2 (HEX) Primer 1

<400>  285
ccaaagcagg gaccacacca ttctt                                             25


<210>  286
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GRN Intron1-Exon2 (HEX) Primer 2

<400>  286
gccctgctgt taaggccacc ca                                                22


<210>  287
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GRN Intron1-Exon2 (HEX) Probe


<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  internal ZEN quencher between nucleotides 9 and 10

<400>  287
cccagctcca cccctgtcgg cagaccatg                                         29


<210>  288
<211>  274
<212>  DNA
<213>  Homo sapiens

<400>  288
gtaggagagc ggccgcgcag acctctcgcc tgctcctgcc caggggcccg ccagggccat       60

gtgagcttga ggttcccctg gagtctcagc cggagacaac agaagaaccg cttactgaaa      120

ctccttgggg gttctgatac actaggggga gttttatggg aaagaggaag cagtaattgc      180

agtgacgccc cgttagagct ttctacctcc ccagcattcc cccaaagcag ggaccacacc      240

attcttgacc cagctccacc cctgtcggta ggtg                                  274


<210>  289
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  289
tcaagaatgg tgtggtcc                                                     18


<210>  290
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  290
ggtcaagaat ggtgtggt                                                     18


<210>  291
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  291
ggaccacacc attcttga                                                     18


<210>  292
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  292
accacaccat tcttgacc                                                     18


