                               SEQUENCE LISTING

<110> APTERNA LIMITED
 
<120> APTAMER-SIRNA FUSIONS

<130> 008124653

<140>
<141>

<150> GB 2019692.9
<151> 2020-12-14

<160> 50    

<170> PatentIn version 3.5

<210> 1
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1
uuuauucaca uuuuugaauu ga                                                22


<210> 2
<211> 87
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 2
gggagacaag aauaaacgcu caaugcguuc acguuuauuc acauuuuuga auugagcaug       60

agcuucgaca ggaggcucac aacaggc                                           87


<210> 3
<211> 43
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 3
ggggcucaau gcguucacgu uuauucacau uuuugaauug agc                         43


<210> 4
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 4
acauuuuu                                                                 8


<210> 5
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 5
auucacauuu uugaau                                                       16


<210> 6
<211> 760
<212> PRT
<213> Homo sapiens

<400> 6
Met Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu 
1               5                   10                  15      


Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp 
            20                  25                  30          


Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Ala 
        35                  40                  45              


Asp Asn Asn Thr Lys Ala Asn Val Thr Lys Pro Lys Arg Cys Ser Gly 
    50                  55                  60                  


Ser Ile Cys Tyr Gly Thr Ile Ala Val Ile Val Phe Phe Leu Ile Gly 
65                  70                  75                  80  


Phe Met Ile Gly Tyr Leu Gly Tyr Cys Lys Gly Val Glu Pro Lys Thr 
                85                  90                  95      


Glu Cys Glu Arg Leu Ala Gly Thr Glu Ser Pro Val Arg Glu Glu Pro 
            100                 105                 110         


Gly Glu Asp Phe Pro Ala Ala Arg Arg Leu Tyr Trp Asp Asp Leu Lys 
        115                 120                 125             


Arg Lys Leu Ser Glu Lys Leu Asp Ser Thr Asp Phe Thr Gly Thr Ile 
    130                 135                 140                 


Lys Leu Leu Asn Glu Asn Ser Tyr Val Pro Arg Glu Ala Gly Ser Gln 
145                 150                 155                 160 


Lys Asp Glu Asn Leu Ala Leu Tyr Val Glu Asn Gln Phe Arg Glu Phe 
                165                 170                 175     


Lys Leu Ser Lys Val Trp Arg Asp Gln His Phe Val Lys Ile Gln Val 
            180                 185                 190         


Lys Asp Ser Ala Gln Asn Ser Val Ile Ile Val Asp Lys Asn Gly Arg 
        195                 200                 205             


Leu Val Tyr Leu Val Glu Asn Pro Gly Gly Tyr Val Ala Tyr Ser Lys 
    210                 215                 220                 


Ala Ala Thr Val Thr Gly Lys Leu Val His Ala Asn Phe Gly Thr Lys 
225                 230                 235                 240 


Lys Asp Phe Glu Asp Leu Tyr Thr Pro Val Asn Gly Ser Ile Val Ile 
                245                 250                 255     


Val Arg Ala Gly Lys Ile Thr Phe Ala Glu Lys Val Ala Asn Ala Glu 
            260                 265                 270         


Ser Leu Asn Ala Ile Gly Val Leu Ile Tyr Met Asp Gln Thr Lys Phe 
        275                 280                 285             


Pro Ile Val Asn Ala Glu Leu Ser Phe Phe Gly His Ala His Leu Gly 
    290                 295                 300                 


Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn His Thr Gln 
305                 310                 315                 320 


Phe Pro Pro Ser Arg Ser Ser Gly Leu Pro Asn Ile Pro Val Gln Thr 
                325                 330                 335     


Ile Ser Arg Ala Ala Ala Glu Lys Leu Phe Gly Asn Met Glu Gly Asp 
            340                 345                 350         


Cys Pro Ser Asp Trp Lys Thr Asp Ser Thr Cys Arg Met Val Thr Ser 
        355                 360                 365             


Glu Ser Lys Asn Val Lys Leu Thr Val Ser Asn Val Leu Lys Glu Ile 
    370                 375                 380                 


Lys Ile Leu Asn Ile Phe Gly Val Ile Lys Gly Phe Val Glu Pro Asp 
385                 390                 395                 400 


His Tyr Val Val Val Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly Ala 
                405                 410                 415     


Ala Lys Ser Gly Val Gly Thr Ala Leu Leu Leu Lys Leu Ala Gln Met 
            420                 425                 430         


Phe Ser Asp Met Val Leu Lys Asp Gly Phe Gln Pro Ser Arg Ser Ile 
        435                 440                 445             


Ile Phe Ala Ser Trp Ser Ala Gly Asp Phe Gly Ser Val Gly Ala Thr 
    450                 455                 460                 


Glu Trp Leu Glu Gly Tyr Leu Ser Ser Leu His Leu Lys Ala Phe Thr 
465                 470                 475                 480 


Tyr Ile Asn Leu Asp Lys Ala Val Leu Gly Thr Ser Asn Phe Lys Val 
                485                 490                 495     


Ser Ala Ser Pro Leu Leu Tyr Thr Leu Ile Glu Lys Thr Met Gln Asn 
            500                 505                 510         


Val Lys His Pro Val Thr Gly Gln Phe Leu Tyr Gln Asp Ser Asn Trp 
        515                 520                 525             


Ala Ser Lys Val Glu Lys Leu Thr Leu Asp Asn Ala Ala Phe Pro Phe 
    530                 535                 540                 


Leu Ala Tyr Ser Gly Ile Pro Ala Val Ser Phe Cys Phe Cys Glu Asp 
545                 550                 555                 560 


Thr Asp Tyr Pro Tyr Leu Gly Thr Thr Met Asp Thr Tyr Lys Glu Leu 
                565                 570                 575     


Ile Glu Arg Ile Pro Glu Leu Asn Lys Val Ala Arg Ala Ala Ala Glu 
            580                 585                 590         


Val Ala Gly Gln Phe Val Ile Lys Leu Thr His Asp Val Glu Leu Asn 
        595                 600                 605             


Leu Asp Tyr Glu Arg Tyr Asn Ser Gln Leu Leu Ser Phe Val Arg Asp 
    610                 615                 620                 


Leu Asn Gln Tyr Arg Ala Asp Ile Lys Glu Met Gly Leu Ser Leu Gln 
625                 630                 635                 640 


Trp Leu Tyr Ser Ala Arg Gly Asp Phe Phe Arg Ala Thr Ser Arg Leu 
                645                 650                 655     


Thr Thr Asp Phe Gly Asn Ala Glu Lys Thr Asp Arg Phe Val Met Lys 
            660                 665                 670         


Lys Leu Asn Asp Arg Val Met Arg Val Glu Tyr His Phe Leu Ser Pro 
        675                 680                 685             


Tyr Val Ser Pro Lys Glu Ser Pro Phe Arg His Val Phe Trp Gly Ser 
    690                 695                 700                 


Gly Ser His Thr Leu Pro Ala Leu Leu Glu Asn Leu Lys Leu Arg Lys 
705                 710                 715                 720 


Gln Asn Asn Gly Ala Phe Asn Glu Thr Leu Phe Arg Asn Gln Leu Ala 
                725                 730                 735     


Leu Ala Thr Trp Thr Ile Gln Gly Ala Ala Asn Ala Leu Ser Gly Asp 
            740                 745                 750         


Val Trp Asp Ile Asp Asn Glu Phe 
        755                 760 


<210> 7
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 7
cugaguaauc acuuaaagau u                                                 21


<210> 8
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 8
ucuuuaagug auuacucagu u                                                 21


<210> 9
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 9
cugaguaauc gcuuaaagau u                                                 21


<210> 10
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 10
ucuuuaagcg auuacucagu u                                                 21


<210> 11
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> variation
<222> (20)..(21)
<223> /replace="u"

<220>
<221> misc_feature
<222> (1)..(21)
<223> /note="Variant nucleotides given in the sequence have no
      preference with respect to those in the annotations
      for variant positions"

<220>
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 11
gcacccugcg gaacuuguut t                                                 21


<210> 12
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> variation
<222> (20)..(20)
<223> /replace="u"

<220>
<221> misc_feature
<222> (21)..(21)
<223> Can be DNA or RNA

<220>
<221> misc_feature
<222> (1)..(21)
<223> /note="Variant nucleotides given in the sequence have no
      preference with respect to those in the annotations
      for variant positions"

<220>
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 12
aacaaguucc gcagggugct g                                                 21


<210> 13
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 13
aacugcuggc cucggcgggu c                                                 21


<210> 14
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 14
gacccgccga ggccagcagu u                                                 21


<210> 15
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-fluoro cytosine

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-fluoro guanine

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methyl adenine

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-fluoro guanine

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-fluoro adenine

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluoro adenine

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-methyl cytosine

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluoro adenine

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-methyl cytosine

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-fluoro adenine

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyl adenine

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-fluoro adenine

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methyl guanine

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-fluoro adenine

<220>
<221> misc_feature
<222> (19)..(20)
<223> /note="phosphorothioate linkage"

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyl uracil

<220>
<221> misc_feature
<222> (20)..(21)
<223> /note="phosphorothioate linkage"

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyl uracil

<400> 15
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210> 16
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyl uracil

<220>
<221> misc_feature
<222> (1)..(2)
<223> /note="phosphorothioate linkage"

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluoro cytosine

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyl uracil

<220>
<221> misc_feature
<222> (3)..(4)
<223> /note="phosphorothioate linkage"

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluoro adenine

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyl adenine

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluoro guanine

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluoro guanine

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methyl adenine

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluoro adenine

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyl cytosine

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyl cytosine

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluoro adenine

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyl guanine

<220>
<221> misc_feature
<222> (19)..(20)
<223> /note="phosphorothioate linkage"

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyl uracil

<220>
<221> misc_feature
<222> (20)..(21)
<223> /note="phosphorothioate linkage"

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyl uracil

<400> 16
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210> 17
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-fluoro guanine

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methyl cytosine

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-fluoro adenine

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methyl cytosine

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-fluoro cytosine

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methyl cytosine

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluoro guanine

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-fluoro cytosine

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-methyl guanine

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluoro guanine

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-methyl adenine

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-fluoro adenine

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methyl cytosine

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-fluoro guanine

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-fluoro uracil

<220>
<221> misc_feature
<222> (19)..(20)
<223> /note="phosphorothioate linkage"

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyl uracil

<220>
<221> misc_feature
<222> (20)..(21)
<223> /note="phosphorothioate linkage"

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyl uracil

<400> 17
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210> 18
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyl adenine

<220>
<221> misc_feature
<222> (1)..(2)
<223> /note="phosphorothioate linkage"

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluoro adenine

<220>
<221> misc_feature
<222> (2)..(3)
<223> /note="phosphorothioate linkage"

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyl cytosine

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluoro adenine

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyl adenine

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluoro guanine

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyl cytosine

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluoro cytosine

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methyl guanine

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-methyl cytosine

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyl adenine

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluoro guanine

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyl guanine

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluoro guanine

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluoro guanine

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyl cytosine

<220>
<221> misc_feature
<222> (19)..(20)
<223> /note="phosphorothioate linkage"

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyl uracil

<220>
<221> misc_feature
<222> (20)..(21)
<223> /note="phosphorothioate linkage"

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyl guanine

<400> 18
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210> 19
<211> 40
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 19
gcucaaugcg uucacguuua uucacauuuu ugaauugagc                             40


<210> 20
<211> 32
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 20
aaugcguuca cguuuauuca cauuuuugaa uu                                     32


<210> 21
<211> 87
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 21
gggagacaag aauaaacgcu caaugcguuu acguuuauuc acauuuuuga auugagcaug       60

agcuucgaca ggaggcucac aacaggc                                           87


<210> 22
<211> 46
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 22
ggggcucaau gcguucacgu uuauucacau uuuugaauug agcaug                      46


<210> 23
<211> 2113
<212> DNA
<213> Homo sapiens

<400> 23
tcccaatccc ggggcggccg ggcgggggtg ggcagggggc gtgaggccgc ccctgcgtcc       60

cgggggcccc ccgaaaacgc gctccgggtg cccggtccct ccgctgcgcc ctgccgccgt      120

cctcccgggg gtctcgggcg gccgcggccg tgtccttcgc gtcccggcgg cgcggcggga      180

ggggccggcg tgacgcagcg gttgctacgg gccgccctta taaataaccg ggctcaggag      240

aaactttagc gagtcagagc cgcgcacggg actgggaagg ggacccaccc gagggtccag      300

ccaccagccc cctcactaat agcggccacc ccggcagcgg cggcagcagc agcagcgacg      360

cagcggcgac agctcagagc agggaggccg cgccacctgc gggccggccg gagcgggcag      420

ccccaggccc cctccccggg cacccgcgtt catgcaacgc ctggtggcct gggacccagc      480

atgtctcccc ctgccgccgc cgccgcctgc ctttaaatcc atggaagtgg ccaacttcta      540

ctacgaggcg gactgcttgg ctgctgcgta cggcggcaag gcggcccccg cggcgccccc      600

cgcggccaga cccgggccgc gcccccccgc cggcgagctg ggcagcatcg gcgaccacga      660

gcgcgccatc gacttcagcc cgtacctgga gccgctgggc gcgccgcagg ccccggcgcc      720

cgccacggcc acggacacct tcgaggcggc tccgcccgcg cccgcccccg cgcccgcctc      780

ctccgggcag caccacgact tcctctccga cctcttctcc gacgactacg ggggcaagaa      840

ctgcaagaag ccggccgagt acggctacgt gagcctgggg cgcctggggg ccgccaaggg      900

cgcgctgcac cccggctgct tcgcgcccct gcacccaccg cccccgccgc cgccgccgcc      960

cgccgagctc aaggcggagc cgggcttcga gcccgcggac tgcaagcgga aggaggaggc     1020

cggggcgccg ggcggcggcg caggcatggc ggcgggcttc ccgtacgcgc tgcgcgctta     1080

cctcggctac caggcggtgc cgagcggcag cagcgggagc ctctccacgt cctcctcgtc     1140

cagcccgccc ggcacgccga gccccgctga cgccaaggcg cccccgaccg cctgctacgc     1200

gggggccgcg ccggcgccct cgcaggtcaa gagcaaggcc aagaagaccg tggacaagca     1260

cagcgacgag tacaagatcc ggcgcgagcg caacaacatc gccgtgcgca agagccgcga     1320

caaggccaag atgcgcaacc tggagacgca gcacaaggtc ctggagctca cggccgagaa     1380

cgagcggctg cagaagaagg tggagcagct gtcgcgcgag ctcagcaccc tgcggaactt     1440

gttcaagcag ctgcccgagc ccctgctcgc ctcctccggc cactgctagc gcggcccccg     1500

cgcgcgtccc cctgccggcc ggggctgaga ctccggggag cgcccgcgcc cgcgccctcg     1560

cccccgcccc cggcggcgcc ggcaaaactt tggcactggg gcacttggca gcgcggggag     1620

cccgtcggta attttaatat tttattatat atatatatct atatttttgt ccaaaccaac     1680

cgcacatgca gatggggctc ccgcccgtgg tgttatttaa agaagaaacg tctatgtgta     1740

cagatgaatg ataaactctc tgcttctccc tctgcccctc tccaggcgcc ggcgggcggg     1800

ccggtttcga agttgatgca atcggtttaa acatggctga acgcgtgtgt acacgggact     1860

gacgcaaccc acgtgtaact gtcagccggg ccctgagtaa tcgcttaaag atgttcctac     1920

gggcttgttg ctgttgatgt tttgttttgt tttgtttttt ggtctttttt tgtattataa     1980

aaaataatct atttctatga gaaaagaggc gtctgtatat tttgggaatc ttttccgttt     2040

caagcattaa gaacactttt aataaacttt tttttgagaa tggttacaaa gccttttggg     2100

ggcagtaaaa aaa                                                        2113


<210> 24
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 24
gaccagugac aaugaccgcu u                                                 21


<210> 25
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 25
aagcggucau ugucacuggu c                                                 21


<210> 26
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-fluoro cytosine

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-fluoro guanine

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methyl adenine

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-fluoro guanine

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-fluoro adenine

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluoro adenine

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-methyl cytosine

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluoro guanine

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-methyl cytosine

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-fluoro adenine

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyl adenine

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-fluoro adenine

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methyl guanine

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-fluoro adenine

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyl uracil

<400> 26
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210> 27
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluoro cytosine

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluoro adenine

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyl adenine

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluoro guanine

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyl cytosine

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluoro guanine

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methyl adenine

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluoro adenine

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyl cytosine

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyl cytosine

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluoro adenine

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyl guanine

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyl uracil

<400> 27
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210> 28
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 28
aacaguguuc uugcucuaua a                                                 21


<210> 29
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 29
uuauagagca agaacacugu u                                                 21


<210> 30
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 30
gggcuucucu uaacauuuau u                                                 21


<210> 31
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 31
uaaauguuaa gagaagcccu u                                                 21


<210> 32
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 32
cuuacgcuga guacuucgau u                                                 21


<210> 33
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 33
ucgaaguacu cagcguaagu u                                                 21


<210> 34
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-fluoro cytosine

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-fluoro cytosine

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluoro uracil

<400> 34
nnnannnana nnnnngaann ga                                                22


<210> 35
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> misc_feature
<222> (1)..(3)
<223> /note="phosphorothioate linkage"

<220>
<221> misc_feature
<222> (19)..(20)
<223> /note="phosphorothioate linkage"

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyl uracil

<220>
<221> misc_feature
<222> (20)..(21)
<223> /note="phosphorothioate linkage"

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyl uracil

<400> 35
ucuuuaagcg auuacucagn n                                                 21


<210> 36
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-fluoro cytosine

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-fluoro cytosine

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluoro uracil

<400> 36
nnnannnana nnnnngaann ga                                                22


<210> 37
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluoro cytosine

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluoro adenine

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyl adenine

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluoro guanine

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyl cytosine

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluoro guanine

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methyl adenine

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluoro adenine

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyl cytosine

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyl cytosine

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluoro adenine

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyl guanine

<220>
<221> misc_feature
<222> (19)..(20)
<223> /note="phosphorothioate linkage"

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyl uracil

<220>
<221> misc_feature
<222> (20)..(21)
<223> /note="phosphorothioate linkage"

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyl uracil

<400> 37
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210> 38
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 38
uuuauucaca uuuuugaauu ga                                                22


<210> 39
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 39
gcggucauug ucacuggucu u                                                 21


<210> 40
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-fluoro cytosine

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-fluoro cytosine

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluoro uracil

<400> 40
nnnannnana nnnnngaann ga                                                22


<210> 41
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-fluoro cytosine

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-fluoro cytosine

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluoro uracil

<400> 41
nnnannnana nnnnngaann ga                                                22


<210> 42
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> misc_feature
<222> (1)..(2)
<223> /note="phosphorothioate linkage"

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluoro adenine

<220>
<221> misc_feature
<222> (2)..(3)
<223> /note="phosphorothioate linkage"

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyl cytosine

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluoro adenine

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyl adenine

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluoro guanine

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyl cytosine

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluoro cytosine

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methyl guanine

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-methyl cytosine

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyl adenine

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluoro guanine

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyl guanine

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluoro guanine

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluoro guanine

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyl cytosine

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyl guanine

<400> 42
annnnnnnnn nnnnnnnnnn n                                                 21


<210> 43
<211> 43
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-fluoro cytosine

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-fluoro cytosine

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoro cytosine

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluoro cytosine

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluoro cytosine

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (24)..(24)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (25)..(25)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (26)..(26)
<223> 2'-fluoro cytosine

<220>
<221> modified_base
<222> (28)..(28)
<223> 2'-fluoro cytosine

<220>
<221> modified_base
<222> (30)..(30)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (31)..(31)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (32)..(32)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (33)..(33)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (34)..(34)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (38)..(38)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (39)..(39)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (43)..(43)
<223> 2'-fluoro cytosine

<400> 43
ggggnnnaan gngnnnangn nnannnanan nnnngaanng agn                         43


<210> 44
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-fluoro cytosine

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-fluoro guanine

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methyl adenine

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-fluoro guanine

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-fluoro adenine

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluoro adenine

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-methyl cytosine

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluoro adenine

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-methyl cytosine

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-fluoro adenine

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyl adenine

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-fluoro adenine

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methyl guanine

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-fluoro adenine

<220>
<221> misc_feature
<222> (19)..(20)
<223> /note="phosphorothioate linkage"

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyl uracil

<220>
<221> misc_feature
<222> (20)..(21)
<223> /note="phosphorothioate linkage"

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyl uracil

<400> 44
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210> 45
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-fluoro cytosine

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methyl adenine

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-fluoro cytosine

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methyl guanine

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-fluoro cytosine

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-fluoro guanine

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-methyl adenine

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluoro guanine

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-fluoro adenine

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methyl cytosine

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-fluoro cytosine

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methyl guanine

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-fluoro adenine

<220>
<221> misc_feature
<222> (19)..(20)
<223> /note="phosphorothioate linkage"

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyl uracil

<220>
<221> misc_feature
<222> (20)..(21)
<223> /note="phosphorothioate linkage"

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyl uracil

<400> 45
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210> 46
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-fluoro cytosine

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-fluoro guanine

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methyl adenine

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-fluoro guanine

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-fluoro adenine

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluoro adenine

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-methyl cytosine

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluoro guanine

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-methyl cytosine

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-fluoro adenine

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyl adenine

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-fluoro adenine

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methyl guanine

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-fluoro adenine

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyl uracil

<400> 46
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210> 47
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyl cytosine

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyl guanine

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methyl adenine

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyl guanine

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyl adenine

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methyl adenine

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyl adenine

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyl adenine

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methyl guanine

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyl adenine

<220>
<221> misc_feature
<222> (19)..(20)
<223> /note="phosphorothioate linkage"

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyl uracil

<220>
<221> misc_feature
<222> (20)..(21)
<223> /note="phosphorothioate linkage"

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyl uracil

<400> 47
nnnnnnnnuc gcuuannnnn n                                                 21


<210> 48
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyl cytosine

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyl guanine

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methyl adenine

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyl guanine

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyl adenine

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methyl adenine

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyl adenine

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyl adenine

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methyl guanine

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyl adenine

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyl uracil

<400> 48
nnnnnnnnuc gcuuannnnn n                                                 21


<210> 49
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 49
gaccagugac aaugaccgcu u                                                 21


<210> 50
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-fluoro guanine

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methyl cytosine

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-fluoro adenine

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methyl cytosine

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-fluoro cytosine

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methyl cytosine

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluoro guanine

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-fluoro cytosine

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-methyl guanine

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluoro guanine

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-methyl adenine

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-fluoro adenine

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methyl cytosine

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-fluoro guanine

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-fluoro uracil

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyl uracil

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyl uracil

<400> 50
nnnnnnnnnn nnnnnnnnnn n                                                 21


