                         SEQUENCE LISTING

<110>  Biomedizinische Forschung & Bio-Produkte AG
 
<120>  PROTECTIVE STAPHYLOCOCCAL EXOTOXIN VACCINE

<130>  BB101P

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  239
<212>  PRT
<213>  Staphylococcus aureus

<400>  1

Glu Ser Gln Pro Asp Pro Lys Pro Asp Glu Leu His Lys Ser Ser Lys 
1               5                   10                  15      


Phe Thr Gly Leu Met Glu Asn Met Lys Val Leu Tyr Asp Asp Asn His 
            20                  25                  30          


Val Ser Ala Ile Asn Val Lys Ser Ile Asp Gln Phe Leu Tyr Phe Asp 
        35                  40                  45              


Leu Ile Tyr Ser Ile Lys Asp Thr Lys Leu Gly Asn Tyr Asp Asn Val 
    50                  55                  60                  


Arg Val Glu Phe Lys Asn Lys Asp Leu Ala Asp Lys Tyr Lys Asp Lys 
65                  70                  75                  80  


Tyr Val Asp Val Phe Gly Ala Asn Tyr Tyr Tyr Gln Cys Tyr Phe Ser 
                85                  90                  95      


Lys Lys Thr Asn Asp Ile Asn Ser His Gln Thr Asp Lys Arg Lys Thr 
            100                 105                 110         


Cys Met Tyr Gly Gly Val Thr Glu His Asn Gly Asn Gln Leu Asp Lys 
        115                 120                 125             


Tyr Arg Ser Ile Thr Val Arg Val Phe Glu Asp Gly Lys Asn Leu Leu 
    130                 135                 140                 


Ser Phe Asp Val Gln Thr Asn Lys Lys Lys Val Thr Ala Gln Glu Leu 
145                 150                 155                 160 


Asp Tyr Leu Thr Arg His Tyr Leu Val Lys Asn Lys Lys Leu Tyr Glu 
                165                 170                 175     


Phe Asn Asn Ser Pro Tyr Glu Thr Gly Tyr Ile Lys Phe Ile Glu Asn 
            180                 185                 190         


Glu Asn Ser Phe Trp Tyr Asp Met Met Pro Ala Pro Gly Asp Lys Phe 
        195                 200                 205             


Asp Gln Ser Lys Tyr Leu Met Met Tyr Asn Asp Asn Lys Met Val Asp 
    210                 215                 220                 


Ser Lys Asp Val Lys Ile Glu Val Tyr Leu Thr Thr Lys Lys Lys 
225                 230                 235                 


<210>  2
<211>  717
<212>  DNA
<213>  Staphylococcus aureus

<400>  2
gagagtcaac cagatcctaa accagatgag ttgcacaaat cgagtaaatt cactggtttg       60

atggaaaata tgaaagtttt gtatgatgat aatcatgtat cagcaataaa cgttaaatct      120

atagatcaat ttctatactt tgacttaata tattctatta aggacactaa gttagggaat      180

tatgataatg ttcgagtcga atttaaaaac aaagatttag ctgataaata caaagataaa      240

tacgtagatg tgtttggagc taattattat tatcaatgtt atttttctaa aaaaacgaat      300

gatattaatt cgcatcaaac tgacaaacga aaaacttgta tgtatggtgg tgtaactgag      360

cataatggaa accaattaga taaatataga agtattactg ttcgggtatt tgaagatggt      420

aaaaatttat tatcttttga cgtacaaact aataagaaaa aggtgactgc tcaagaatta      480

gattacctaa ctcgtcacta tttggtgaaa aataaaaaac tctatgaatt taacaactcg      540

ccttatgaaa cgggatatat taaatttata gaaaatgaga atagcttttg gtatgacatg      600

atgcctgcac caggagataa atttgaccaa tctaaatatt taatgatgta caatgacaat      660

aaaatggttg attctaaaga tgtgaagatt gaagtttatc ttacgacaaa gaaaaag         717


<210>  3
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant SEB

<400>  3

Glu Ser Gln Pro Asp Pro Lys Pro Asp Glu Leu His Lys Ser Ser Lys 
1               5                   10                  15      


Phe Thr Gly Leu Met Lys Val Leu Tyr Asp Asp Asn His Val Ser Ala 
            20                  25                  30          


Ile Asn Val Lys Ser Ile Asp Gln Phe Leu Tyr Phe Asp Leu Ile Tyr 
        35                  40                  45              


Ser Ile Lys Asp Thr Lys Leu Gly Asn Tyr Asp Asn Val Arg Val Glu 
    50                  55                  60                  


Phe Lys Asn Lys Asp Leu Ala Asp Lys Tyr Lys Asp Lys Tyr Val Asp 
65                  70                  75                  80  


Val Phe Gly Ala Asn Tyr Tyr Tyr Gln Cys Tyr Phe Ser Lys Lys Thr 
                85                  90                  95      


Asn Asp Ile Asn Ser His Gln Thr Asp Lys Arg Lys Thr Cys Met Tyr 
            100                 105                 110         


Gly Gly Val Thr Glu His Asn Gly Asn Gln Leu Asp Lys Tyr Arg Ser 
        115                 120                 125             


Ile Thr Val Arg Val Phe Glu Asp Gly Lys Asn Leu Leu Ser Phe Asp 
    130                 135                 140                 


Val Gln Thr Asn Lys Lys Lys Val Thr Ala Gln Glu Leu Asp Tyr Leu 
145                 150                 155                 160 


Thr Arg His Tyr Leu Val Lys Asn Lys Lys Leu Tyr Glu Phe Asn Asn 
                165                 170                 175     


Ser Pro Tyr Glu Thr Gly Tyr Ile Lys Phe Ile Glu Asn Glu Asn Ser 
            180                 185                 190         


Phe Trp Tyr Asp Met Met Pro Ala Pro Gly Asp Lys Phe Asp Gln Ser 
        195                 200                 205             


Lys Tyr Leu Met Met Tyr Asn Asp Asn Lys Met Val Asp Ser Lys Asp 
    210                 215                 220                 


Val Lys Ile Glu Val Tyr Leu Thr Thr Lys Lys Lys 
225                 230                 235     


<210>  4
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutant SEB

<400>  4
gagagtcaac cagatcctaa accagatgag ttgcacaaat cgagtaaatt cactggtttg       60

atgaaagttt tgtatgatga taatcatgta tcagcaataa acgttaaatc tatagatcaa      120

tttctatact ttgacttaat atattctatt aaggacacta agttagggaa ttatgataat      180

gttcgagtcg aatttaaaaa caaagattta gctgataaat acaaagataa atacgtagat      240

gtgtttggag ctaattatta ttatcaatgt tatttttcta aaaaaacgaa tgatattaat      300

tcgcatcaaa ctgacaaacg aaaaacttgt atgtatggtg gtgtaactga gcataatgga      360

aaccaattag ataaatatag aagtattact gttcgggtat ttgaagatgg taaaaattta      420

ttatcttttg acgtacaaac taataagaaa aaggtgactg ctcaagaatt agattaccta      480

actcgtcact atttggtgaa aaataaaaaa ctctatgaat ttaacaactc gccttatgaa      540

acgggatata ttaaatttat agaaaatgag aatagctttt ggtatgacat gatgcctgca      600

ccaggagata aatttgacca atctaaatat ttaatgatgt acaatgacaa taaaatggtt      660

gattctaaag atgtgaagat tgaagtttat cttacgacaa agaaaaag                   708


<210>  5
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant SEB

<400>  5

Glu Ser Gln Pro Asp Pro Lys Pro Asp Glu Leu His Lys Ser Ser Lys 
1               5                   10                  15      


Phe Thr Gly Leu Met Lys Val Leu Tyr Asp Asp Asn His Val Ser Ala 
            20                  25                  30          


Ile Asn Val Lys Ser Ile Asp Gln Phe Arg Tyr Phe Asp Leu Ile Tyr 
        35                  40                  45              


Ser Ile Lys Asp Thr Lys Leu Gly Asn Tyr Asp Asn Val Arg Val Glu 
    50                  55                  60                  


Phe Lys Asn Lys Asp Leu Ala Asp Lys Tyr Lys Asp Lys Tyr Val Asp 
65                  70                  75                  80  


Val Phe Gly Ala Asn Tyr Tyr Tyr Gln Cys Tyr Phe Ser Lys Lys Thr 
                85                  90                  95      


Asn Asp Ile Asn Ser His Gln Thr Asp Lys Arg Lys Thr Cys Met Tyr 
            100                 105                 110         


Gly Gly Val Thr Glu His Asn Gly Asn Gln Leu Asp Lys Tyr Arg Ser 
        115                 120                 125             


Ile Thr Val Arg Val Phe Glu Asp Gly Lys Asn Leu Leu Ser Phe Asp 
    130                 135                 140                 


Val Gln Thr Asn Lys Lys Lys Val Thr Ala Gln Glu Leu Asp Tyr Leu 
145                 150                 155                 160 


Thr Arg His Tyr Leu Val Lys Asn Lys Lys Leu Tyr Glu Phe Asn Asn 
                165                 170                 175     


Ser Pro Tyr Glu Thr Gly Tyr Ile Lys Phe Ile Glu Asn Glu Asn Ser 
            180                 185                 190         


Phe Trp Tyr Asp Met Met Pro Ala Pro Gly Asp Lys Phe Asp Gln Ser 
        195                 200                 205             


Lys Tyr Leu Met Met Tyr Asn Asp Asn Lys Met Val Asp Ser Lys Asp 
    210                 215                 220                 


Val Lys Ile Glu Val Tyr Leu Thr Thr Lys Lys Lys 
225                 230                 235     


<210>  6
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutant SEB

<400>  6
gagagtcaac cagatcctaa accagatgag ttgcacaaat cgagtaaatt cactggtttg       60

atgaaagttt tgtatgatga taatcatgta tcagcaataa acgttaaatc tatagatcaa      120

tttagatact ttgacttaat atattctatt aaggacacta agttagggaa ttatgataat      180

gttcgagtcg aatttaaaaa caaagattta gctgataaat acaaagataa atacgtagat      240

gtgtttggag ctaattatta ttatcaatgt tatttttcta aaaaaacgaa tgatattaat      300

tcgcatcaaa ctgacaaacg aaaaacttgt atgtatggtg gtgtaactga gcataatgga      360

aaccaattag ataaatatag aagtattact gttcgggtat ttgaagatgg taaaaattta      420

ttatcttttg acgtacaaac taataagaaa aaggtgactg ctcaagaatt agattaccta      480

actcgtcact atttggtgaa aaataaaaaa ctctatgaat ttaacaactc gccttatgaa      540

acgggatata ttaaatttat agaaaatgag aatagctttt ggtatgacat gatgcctgca      600

ccaggagata aatttgacca atctaaatat ttaatgatgt acaatgacaa taaaatggtt      660

gattctaaag atgtgaagat tgaagtttat cttacgacaa agaaaaag                   708


<210>  7
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant SEB

<400>  7

Glu Ser Gln Pro Asp Pro Lys Pro Asp Glu Leu His Lys Ser Ser Lys 
1               5                   10                  15      


Phe Thr Gly Leu Met Lys Val Leu Tyr Asp Asp Asn His Val Ser Ala 
            20                  25                  30          


Ile Asn Val Lys Ser Ile Asp Pro Phe Leu Tyr Phe Asp Leu Ile Tyr 
        35                  40                  45              


Ser Ile Lys Asp Thr Lys Leu Gly Asn Tyr Asp Asn Val Arg Val Glu 
    50                  55                  60                  


Phe Lys Asn Lys Asp Leu Ala Asp Lys Tyr Lys Asp Lys Tyr Val Asp 
65                  70                  75                  80  


Val Phe Gly Ala Asn Tyr Tyr Tyr Gln Cys Tyr Phe Ser Lys Lys Thr 
                85                  90                  95      


Asn Asp Ile Asn Ser His Gln Thr Asp Lys Arg Lys Thr Cys Met Tyr 
            100                 105                 110         


Gly Gly Val Thr Glu His Asn Gly Asn Gln Leu Asp Lys Tyr Arg Ser 
        115                 120                 125             


Ile Thr Val Arg Val Phe Glu Asp Gly Lys Asn Leu Leu Ser Phe Asp 
    130                 135                 140                 


Val Gln Thr Asn Lys Lys Lys Val Thr Ala Gln Glu Leu Asp Tyr Leu 
145                 150                 155                 160 


Thr Arg His Tyr Leu Val Lys Asn Lys Lys Leu Tyr Glu Phe Asn Asn 
                165                 170                 175     


Ser Pro Tyr Glu Thr Gly Tyr Ile Lys Phe Ile Glu Asn Glu Asn Ser 
            180                 185                 190         


Phe Trp Tyr Asp Met Met Pro Ala Pro Gly Asp Lys Phe Asp Gln Ser 
        195                 200                 205             


Lys Tyr Leu Met Met Tyr Asn Asp Asn Lys Met Val Asp Ser Lys Asp 
    210                 215                 220                 


Val Lys Ile Glu Val Tyr Leu Thr Thr Lys Lys Lys 
225                 230                 235     


<210>  8
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutant SEB

<400>  8
gagagtcaac cagatcctaa accagatgag ttgcacaaat cgagtaaatt cactggtttg       60

atgaaagttt tgtatgatga taatcatgta tcagcaataa acgttaaatc tatagatccg      120

tttctatact ttgacttaat atattctatt aaggacacta agttagggaa ttatgataat      180

gttcgagtcg aatttaaaaa caaagattta gctgataaat acaaagataa atacgtagat      240

gtgtttggag ctaattatta ttatcaatgt tatttttcta aaaaaacgaa tgatattaat      300

tcgcatcaaa ctgacaaacg aaaaacttgt atgtatggtg gtgtaactga gcataatgga      360

aaccaattag ataaatatag aagtattact gttcgggtat ttgaagatgg taaaaattta      420

ttatcttttg acgtacaaac taataagaaa aaggtgactg ctcaagaatt agattaccta      480

actcgtcact atttggtgaa aaataaaaaa ctctatgaat ttaacaactc gccttatgaa      540

acgggatata ttaaatttat agaaaatgag aatagctttt ggtatgacat gatgcctgca      600

ccaggagata aatttgacca atctaaatat ttaatgatgt acaatgacaa taaaatggtt      660

gattctaaag atgtgaagat tgaagtttat cttacgacaa agaaaaag                   708


<210>  9
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant SEB

<400>  9

Glu Ser Gln Pro Asp Pro Lys Pro Asp Glu Leu His Lys Ser Ser Lys 
1               5                   10                  15      


Phe Thr Gly Leu Met Lys Val Leu Tyr Asp Asp Asn His Val Ser Ala 
            20                  25                  30          


Ile Asn Val Lys Ser Ile Asp Gln Pro Leu Tyr Phe Asp Leu Ile Tyr 
        35                  40                  45              


Ser Ile Lys Asp Thr Lys Leu Gly Asn Tyr Asp Asn Val Arg Val Glu 
    50                  55                  60                  


Phe Lys Asn Lys Asp Leu Ala Asp Lys Tyr Lys Asp Lys Tyr Val Asp 
65                  70                  75                  80  


Val Phe Gly Ala Asn Tyr Tyr Tyr Gln Cys Tyr Phe Ser Lys Lys Thr 
                85                  90                  95      


Asn Asp Ile Asn Ser His Gln Thr Asp Lys Arg Lys Thr Cys Met Tyr 
            100                 105                 110         


Gly Gly Val Thr Glu His Asn Gly Asn Gln Leu Asp Lys Tyr Arg Ser 
        115                 120                 125             


Ile Thr Val Arg Val Phe Glu Asp Gly Lys Asn Leu Leu Ser Phe Asp 
    130                 135                 140                 


Val Gln Thr Asn Lys Lys Lys Val Thr Ala Gln Glu Leu Asp Tyr Leu 
145                 150                 155                 160 


Thr Arg His Tyr Leu Val Lys Asn Lys Lys Leu Tyr Glu Phe Asn Asn 
                165                 170                 175     


Ser Pro Tyr Glu Thr Gly Tyr Ile Lys Phe Ile Glu Asn Glu Asn Ser 
            180                 185                 190         


Phe Trp Tyr Asp Met Met Pro Ala Pro Gly Asp Lys Phe Asp Gln Ser 
        195                 200                 205             


Lys Tyr Leu Met Met Tyr Asn Asp Asn Lys Met Val Asp Ser Lys Asp 
    210                 215                 220                 


Val Lys Ile Glu Val Tyr Leu Thr Thr Lys Lys Lys 
225                 230                 235     


<210>  10
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutant SEB

<400>  10
gagagtcaac cagatcctaa accagatgag ttgcacaaat cgagtaaatt cactggtttg       60

atgaaagttt tgtatgatga taatcatgta tcagcaataa acgttaaatc tatagatcaa      120

ccgctatact ttgacttaat atattctatt aaggacacta agttagggaa ttatgataat      180

gttcgagtcg aatttaaaaa caaagattta gctgataaat acaaagataa atacgtagat      240

gtgtttggag ctaattatta ttatcaatgt tatttttcta aaaaaacgaa tgatattaat      300

tcgcatcaaa ctgacaaacg aaaaacttgt atgtatggtg gtgtaactga gcataatgga      360

aaccaattag ataaatatag aagtattact gttcgggtat ttgaagatgg taaaaattta      420

ttatcttttg acgtacaaac taataagaaa aaggtgactg ctcaagaatt agattaccta      480

actcgtcact atttggtgaa aaataaaaaa ctctatgaat ttaacaactc gccttatgaa      540

acgggatata ttaaatttat agaaaatgag aatagctttt ggtatgacat gatgcctgca      600

ccaggagata aatttgacca atctaaatat ttaatgatgt acaatgacaa taaaatggtt      660

gattctaaag atgtgaagat tgaagtttat cttacgacaa agaaaaag                   708


<210>  11
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant SEB

<400>  11

Glu Ser Gln Pro Asp Pro Lys Pro Asp Glu Leu His Lys Ser Ser Lys 
1               5                   10                  15      


Phe Thr Gly Leu Met Lys Val Leu Tyr Asp Asp Asn His Val Ser Ala 
            20                  25                  30          


Ile Asn Val Lys Ser Ile Asp Gln Ser Leu Tyr Phe Asp Leu Ile Tyr 
        35                  40                  45              


Ser Ile Lys Asp Thr Lys Leu Gly Asn Tyr Asp Asn Val Arg Val Glu 
    50                  55                  60                  


Phe Lys Asn Lys Asp Leu Ala Asp Lys Tyr Lys Asp Lys Tyr Val Asp 
65                  70                  75                  80  


Val Phe Gly Ala Asn Tyr Tyr Tyr Gln Cys Tyr Phe Ser Lys Lys Thr 
                85                  90                  95      


Asn Asp Ile Asn Ser His Gln Thr Asp Lys Arg Lys Thr Cys Met Tyr 
            100                 105                 110         


Gly Gly Val Thr Glu His Asn Gly Asn Gln Leu Asp Lys Tyr Arg Ser 
        115                 120                 125             


Ile Thr Val Arg Val Phe Glu Asp Gly Lys Asn Leu Leu Ser Phe Asp 
    130                 135                 140                 


Val Gln Thr Asn Lys Lys Lys Val Thr Ala Gln Glu Leu Asp Tyr Leu 
145                 150                 155                 160 


Thr Arg His Tyr Leu Val Lys Asn Lys Lys Leu Tyr Glu Phe Asn Asn 
                165                 170                 175     


Ser Pro Tyr Glu Thr Gly Tyr Ile Lys Phe Ile Glu Asn Glu Asn Ser 
            180                 185                 190         


Phe Trp Tyr Asp Met Met Pro Ala Pro Gly Asp Lys Phe Asp Gln Ser 
        195                 200                 205             


Lys Tyr Leu Met Met Tyr Asn Asp Asn Lys Met Val Asp Ser Lys Asp 
    210                 215                 220                 


Val Lys Ile Glu Val Tyr Leu Thr Thr Lys Lys Lys 
225                 230                 235     


<210>  12
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutant SEB

<400>  12
gagagtcaac cagatcctaa accagatgag ttgcacaaat cgagtaaatt cactggtttg       60

atgaaagttt tgtatgatga taatcatgta tcagcaataa acgttaaatc tatagatcaa      120

agcctatact ttgacttaat atattctatt aaggacacta agttagggaa ttatgataat      180

gttcgagtcg aatttaaaaa caaagattta gctgataaat acaaagataa atacgtagat      240

gtgtttggag ctaattatta ttatcaatgt tatttttcta aaaaaacgaa tgatattaat      300

tcgcatcaaa ctgacaaacg aaaaacttgt atgtatggtg gtgtaactga gcataatgga      360

aaccaattag ataaatatag aagtattact gttcgggtat ttgaagatgg taaaaattta      420

ttatcttttg acgtacaaac taataagaaa aaggtgactg ctcaagaatt agattaccta      480

actcgtcact atttggtgaa aaataaaaaa ctctatgaat ttaacaactc gccttatgaa      540

acgggatata ttaaatttat agaaaatgag aatagctttt ggtatgacat gatgcctgca      600

ccaggagata aatttgacca atctaaatat ttaatgatgt acaatgacaa taaaatggtt      660

gattctaaag atgtgaagat tgaagtttat cttacgacaa agaaaaag                   708


<210>  13
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant SEB

<400>  13

Glu Ser Gln Pro Asp Pro Lys Pro Asp Glu Leu His Lys Ser Ser Lys 
1               5                   10                  15      


Phe Thr Gly Leu Met Lys Val Leu Tyr Asp Asp Asn His Val Ser Ala 
            20                  25                  30          


Ile Asn Val Lys Ser Ile Asp Gln Phe Arg Tyr Phe Asp Leu Ile Tyr 
        35                  40                  45              


Ser Ile Lys Asp Thr Lys Leu Gly Asn Tyr Asp Asn Val Arg Val Glu 
    50                  55                  60                  


Phe Lys Asn Lys Asp Leu Ala Asp Lys Tyr Lys Asp Lys Tyr Val Asp 
65                  70                  75                  80  


Val Phe Gly Ala Asn Tyr Tyr Tyr Gln Cys Tyr Phe Ser Lys Lys Thr 
                85                  90                  95      


Asn Asp Ile Asn Ser His Gln Thr Asp Lys Arg Lys Thr Cys Met Tyr 
            100                 105                 110         


Gly Gly Val Thr Glu His Asn Gly Asn Gln Leu Asp Lys Tyr Arg Ser 
        115                 120                 125             


Ile Thr Val Arg Val Phe Glu Asp Gly Lys Asn Leu Leu Ser Phe Asp 
    130                 135                 140                 


Val Gln Thr Asn Lys Lys Lys Val Thr Ala Gln Glu Leu Asp Tyr Leu 
145                 150                 155                 160 


Thr Arg His Tyr Leu Val Lys Asn Lys Lys Leu Tyr Glu Phe Asn Asn 
                165                 170                 175     


Ser Pro Tyr Glu Thr Gly Tyr Ile Lys Phe Ile Glu Asn Glu Asn Ser 
            180                 185                 190         


Phe Trp Tyr Asp Met Met Pro Ala Pro Gly Asp Lys Phe Asp Gln Ser 
        195                 200                 205             


Lys Tyr Leu Met Met Tyr Asn Asp Asn Lys Met Val Asp Ser Lys Asp 
    210                 215                 220                 


Val Lys Ile Glu Val Tyr Leu Thr Thr Lys Lys Lys Lys Leu Glu Ser 
225                 230                 235                 240 


Gln Pro Asp Pro Lys Pro Asp Glu Leu His Lys Ser Ser Lys Phe Thr 
                245                 250                 255     


Gly Leu Met Lys Val Leu Tyr Asp Asp Asn His Val Ser Ala Ile Asn 
            260                 265                 270         


Val Lys Ser Ile Asp Gln Phe Arg Tyr Phe Asp Leu Ile Tyr Ser Ile 
        275                 280                 285             


Lys Asp Thr Lys Leu Gly Asn Tyr Asp Asn Val Arg Val Glu Phe Lys 
    290                 295                 300                 


Asn Lys Asp Leu Ala Asp Lys Tyr Lys Asp Lys Tyr Val Asp Val Phe 
305                 310                 315                 320 


Gly Ala Asn Tyr Tyr Tyr Gln Cys Tyr Phe Ser Lys Lys Thr Asn Asp 
                325                 330                 335     


Ile Asn Ser His Gln Thr Asp Lys Arg Lys Thr Cys Met Tyr Gly Gly 
            340                 345                 350         


Val Thr Glu His Asn Gly Asn Gln Leu Asp Lys Tyr Arg Ser Ile Thr 
        355                 360                 365             


Val Arg Val Phe Glu Asp Gly Lys Asn Leu Leu Ser Phe Asp Val Gln 
    370                 375                 380                 


Thr Asn Lys Lys Lys Val Thr Ala Gln Glu Leu Asp Tyr Leu Thr Arg 
385                 390                 395                 400 


His Tyr Leu Val Lys Asn Lys Lys Leu Tyr Glu Phe Asn Asn Ser Pro 
                405                 410                 415     


Tyr Glu Thr Gly Tyr Ile Lys Phe Ile Glu Asn Glu Asn Ser Phe Trp 
            420                 425                 430         


Tyr Asp Met Met Pro Ala Pro Gly Asp Lys Phe Asp Gln Ser Lys Tyr 
        435                 440                 445             


Leu Met Met Tyr Asn Asp Asn Lys Met Val Asp Ser Lys Asp Val Lys 
    450                 455                 460                 


Ile Glu Val Tyr Leu Thr Thr Lys Lys Lys 
465                 470                 


<210>  14
<211>  1422
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutant SEB

<400>  14
gagagtcaac cagatcctaa accagatgag ttgcacaaat cgagtaaatt cactggtttg       60

atgaaagttt tgtatgatga taatcatgta tcagcaataa acgttaaatc tatagatcaa      120

tttagatact ttgacttaat atattctatt aaggacacta agttagggaa ttatgataat      180

gttcgagtcg aatttaaaaa caaagattta gctgataaat acaaagataa atacgtagat      240

gtgtttggag ctaattatta ttatcaatgt tatttttcta aaaaaacgaa tgatattaat      300

tcgcatcaaa ctgacaaacg aaaaacttgt atgtatggtg gtgtaactga gcataatgga      360

aaccaattag ataaatatag aagtattact gttcgggtat ttgaagatgg taaaaattta      420

ttatcttttg acgtacaaac taataagaaa aaggtgactg ctcaagaatt agattaccta      480

actcgtcact atttggtgaa aaataaaaaa ctctatgaat ttaacaactc gccttatgaa      540

acgggatata ttaaatttat agaaaatgag aatagctttt ggtatgacat gatgcctgca      600

ccaggagata aatttgacca atctaaatat ttaatgatgt acaatgacaa taaaatggtt      660

gattctaaag atgtgaagat tgaagtttat cttacgacaa agaaaaagaa gcttgagagt      720

caaccagatc ctaaaccaga tgagttgcac aaatcgagta aattcactgg tttgatgaaa      780

gttttgtatg atgataatca tgtatcagca ataaacgtta aatctataga tcaatttaga      840

tactttgact taatatattc tattaaggac actaagttag ggaattatga taatgttcga      900

gtcgaattta aaaacaaaga tttagctgat aaatacaaag ataaatacgt agatgtgttt      960

ggagctaatt attattatca atgttatttt tctaaaaaaa cgaatgatat taattcgcat     1020

caaactgaca aacgaaaaac ttgtatgtat ggtggtgtaa ctgagcataa tggaaaccaa     1080

ttagataaat atagaagtat tactgttcgg gtatttgaag atggtaaaaa tttattatct     1140

tttgacgtac aaactaataa gaaaaaggtg actgctcaag aattagatta cctaactcgt     1200

cactatttgg tgaaaaataa aaaactctat gaatttaaca actcgcctta tgaaacggga     1260

tatattaaat ttatagaaaa tgagaatagc ttttggtatg acatgatgcc tgcaccagga     1320

gataaatttg accaatctaa atatttaatg atgtacaatg acaataaaat ggttgattct     1380

aaagatgtga agattgaagt ttatcttacg acaaagaaaa ag                        1422


<210>  15
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant SEB

<400>  15

Glu Ser Gln Pro Asp Pro Lys Pro Asp Glu Leu His Lys Ser Ser Lys 
1               5                   10                  15      


Phe Thr Gly Leu Met Glu Asn Met Lys Val Leu Tyr Asp Asp Asn His 
            20                  25                  30          


Val Ser Ala Ile Asn Val Lys Ser Ile Asp Gln Phe Arg Tyr Phe Asp 
        35                  40                  45              


Leu Ile Tyr Ser Ile Lys Asp Thr Lys Leu Gly Asn Tyr Asp Asn Val 
    50                  55                  60                  


Arg Val Glu Phe Lys Asn Lys Asp Leu Ala Asp Lys Tyr Lys Asp Lys 
65                  70                  75                  80  


Tyr Val Asp Val Phe Gly Ala Asn Tyr Tyr Tyr Gln Cys Tyr Phe Ser 
                85                  90                  95      


Lys Lys Thr Asn Asp Ile Asn Ser His Gln Thr Asp Lys Arg Lys Thr 
            100                 105                 110         


Cys Met Tyr Gly Gly Val Thr Glu His Asn Gly Asn Gln Leu Asp Lys 
        115                 120                 125             


Tyr Arg Ser Ile Thr Val Arg Val Phe Glu Asp Gly Lys Asn Leu Leu 
    130                 135                 140                 


Ser Phe Asp Val Gln Thr Asn Lys Lys Lys Val Thr Ala Gln Glu Leu 
145                 150                 155                 160 


Asp Tyr Leu Thr Arg His Tyr Leu Val Lys Asn Lys Lys Leu Tyr Glu 
                165                 170                 175     


Phe Asn Asn Ser Pro Tyr Glu Thr Gly Tyr Ile Lys Phe Ile Glu Asn 
            180                 185                 190         


Glu Asn Ser Phe Trp Tyr Asp Met Met Pro Ala Pro Gly Asp Lys Phe 
        195                 200                 205             


Asp Gln Ser Lys Tyr Leu Met Met Tyr Asn Asp Asn Lys Met Val Asp 
    210                 215                 220                 


Ser Lys Asp Val Lys Ile Glu Val Tyr Leu Thr Thr Lys Lys Lys 
225                 230                 235                 


<210>  16
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutant SEB

<400>  16
gagagtcaac cagatcctaa accagatgag ttgcacaaat cgagtaaatt cactggtttg       60

atggaaaata tgaaagtttt gtatgatgat aatcatgtat cagcaataaa cgttaaatct      120

atagatcaat ttagatactt tgacttaata tattctatta aggacactaa gttagggaat      180

tatgataatg ttcgagtcga atttaaaaac aaagatttag ctgataaata caaagataaa      240

tacgtagatg tgtttggagc taattattat tatcaatgtt atttttctaa aaaaacgaat      300

gatattaatt cgcatcaaac tgacaaacga aaaacttgta tgtatggtgg tgtaactgag      360

cataatggaa accaattaga taaatataga agtattactg ttcgggtatt tgaagatggt      420

aaaaatttat tatcttttga cgtacaaact aataagaaaa aggtgactgc tcaagaatta      480

gattacctaa ctcgtcacta tttggtgaaa aataaaaaac tctatgaatt taacaactcg      540

ccttatgaaa cgggatatat taaatttata gaaaatgaga atagcttttg gtatgacatg      600

atgcctgcac caggagataa atttgaccaa tctaaatatt taatgatgta caatgacaat      660

aaaatggttg attctaaaga tgtgaagatt gaagtttatc ttacgacaaa gaaaaag         717


<210>  17
<211>  239
<212>  PRT
<213>  Staphylococcus aureus

<400>  17

Glu Ser Gln Pro Asp Pro Lys Pro Asp Glu Leu His Lys Ala Ser Lys 
1               5                   10                  15      


Phe Thr Gly Leu Met Glu Asn Met Lys Val Leu Tyr Asp Asp Asn His 
            20                  25                  30          


Val Ser Ala Ile Asn Val Lys Ser Ile Asp Gln Phe Leu Tyr Phe Asp 
        35                  40                  45              


Leu Ile Tyr Ser Ile Lys Asp Thr Lys Leu Gly Asn Tyr Asp Asn Val 
    50                  55                  60                  


Arg Val Glu Phe Lys Asn Lys Asp Leu Ala Asp Lys Tyr Lys Asp Lys 
65                  70                  75                  80  


Tyr Val Asp Val Phe Gly Ala Asn Tyr Tyr Tyr Gln Cys Tyr Phe Ser 
                85                  90                  95      


Lys Lys Thr Asn Asp Ile Asn Ser His Gln Thr Asp Lys Arg Lys Thr 
            100                 105                 110         


Cys Met Tyr Gly Gly Val Thr Glu His Asn Gly Asn Gln Leu Asp Lys 
        115                 120                 125             


Tyr Arg Ser Ile Thr Val Arg Val Phe Glu Asp Gly Lys Asn Leu Leu 
    130                 135                 140                 


Ser Phe Asp Val Gln Thr Asn Lys Lys Lys Val Thr Ala Gln Glu Leu 
145                 150                 155                 160 


Asp Tyr Leu Thr Arg His Tyr Leu Val Lys Asn Lys Lys Leu Tyr Glu 
                165                 170                 175     


Phe Asn Asn Ser Pro Tyr Glu Thr Gly Tyr Ile Lys Phe Ile Glu Asn 
            180                 185                 190         


Glu Asn Ser Phe Trp Tyr Asp Met Met Pro Ala Pro Gly Asp Lys Phe 
        195                 200                 205             


Asp Gln Ser Lys Tyr Leu Met Met Tyr Asn Asp Asn Lys Met Val Asp 
    210                 215                 220                 


Ser Lys Asp Val Lys Ile Glu Val Tyr Leu Thr Thr Lys Lys Lys 
225                 230                 235                 


<210>  18
<211>  717
<212>  DNA
<213>  Staphylococcus aureus

<400>  18
gagagtcaac cagatcctaa accagatgag ttgcacaaag cgagtaaatt cactggtttg       60

atggaaaata tgaaagtttt gtatgatgat aatcatgtat cagcaataaa cgttaaatct      120

atagatcaat ttctatactt tgacttaata tattctatta aggacactaa gttagggaat      180

tatgataatg ttcgagtcga atttaaaaac aaagatttag ctgataaata caaagataaa      240

tacgtagatg tgtttggagc taattattac tatcaatgtt atttttctaa aaaaacgaat      300

gatattaatt cacatcaaac tgacaaacga aaaacttgta tgtatggtgg tgtaactgag      360

cataatggaa accaattaga taaatataga agtattactg ttcgggtatt tgaagatggt      420

aaaaatttat tatcttttga cgtacaaact aataagaaaa aagtgactgc tcaagaatta      480

gattacctaa ctcgtcacta tttggtgaaa aataaaaaac tctatgaatt taacaactcg      540

ccttatgaaa cgggatatat taaatttata gaaaatgaga atagcttttg gtatgacatg      600

atgcctgcac caggagataa atttgaccaa tctaaatatt taatgatgta caatgacaat      660

aaaatggttg attctaaaga tgtgaagatt gaagtttatc ttacgacaaa gaaaaag         717


<210>  19
<211>  239
<212>  PRT
<213>  Staphylococcus aureus

<400>  19

Glu Ser Gln Pro Asp Pro Lys Pro Asp Glu Leu His Lys Ser Ser Lys 
1               5                   10                  15      


Phe Thr Gly Leu Met Glu Asn Met Lys Val Leu Tyr Asp Asp Asn His 
            20                  25                  30          


Val Ser Ala Ile Asn Val Lys Ser Ile Asp Gln Phe Leu Tyr Phe Asp 
        35                  40                  45              


Leu Ile Tyr Ser Ile Lys Asp Thr Lys Leu Gly Asn Tyr Asp Asn Val 
    50                  55                  60                  


Arg Val Glu Phe Lys Asn Lys Asp Leu Ala Asp Lys Tyr Lys Asp Lys 
65                  70                  75                  80  


Tyr Val Asp Val Phe Gly Ala Asn Tyr Tyr Tyr Gln Cys Tyr Phe Ser 
                85                  90                  95      


Lys Lys Thr Asn Asp Ile Asn Ser His Gln Thr Asp Lys Arg Lys Thr 
            100                 105                 110         


Cys Met Tyr Gly Gly Val Thr Glu His Asn Gly Asn Gln Leu Asp Lys 
        115                 120                 125             


Tyr Arg Ser Ile Ser Val Arg Val Phe Glu Asp Gly Lys Asn Leu Leu 
    130                 135                 140                 


Ser Phe Asp Val Gln Thr Asn Lys Lys Lys Val Thr Ala Gln Glu Leu 
145                 150                 155                 160 


Asp Tyr Leu Thr Arg His Tyr Leu Val Lys Asn Lys Lys Leu Tyr Glu 
                165                 170                 175     


Phe Asn Asn Ser Pro Tyr Glu Thr Gly Tyr Ile Lys Phe Ile Glu Asn 
            180                 185                 190         


Glu Asn Ser Phe Trp Tyr Asp Met Met Pro Ala Pro Gly Asp Lys Phe 
        195                 200                 205             


Asp Gln Ser Lys Tyr Leu Met Met Tyr Asn Asp Asn Lys Met Val Asp 
    210                 215                 220                 


Ser Lys Asp Val Lys Ile Glu Val Tyr Leu Thr Thr Lys Lys Lys 
225                 230                 235                 


<210>  20
<211>  717
<212>  DNA
<213>  Staphylococcus aureus

<400>  20
gagagtcaac cagatcctaa accagatgag ttgcacaaat cgagtaaatt cactggtttg       60

atggaaaata tgaaagtttt gtatgatgat aatcatgtat cagcaataaa cgttaaatct      120

atagatcaat ttctatactt tgacttaata tattctatta aggacactaa gttagggaat      180

tatgataatg ttcgagtcga atttaaaaac aaagatttag ctgataaata caaagataaa      240

tacgtagatg tgtttggagc taattattat tatcaatgtt atttttctaa aaaaacgaat      300

gatattaatt cgcatcaaac tgacaaacga aaaacttgta tgtatggtgg tgtaactgag      360

cataatggaa accaattaga taaatataga agtatttctg ttcgggtatt tgaagatggt      420

aaaaatttat tatcttttga cgtacaaact aataagaaaa aggtgactgc tcaagaatta      480

gattacctaa ctcgtcacta tttggtgaaa aataaaaaac tctatgaatt taacaactcg      540

ccttatgaaa cgggatatat taaatttata gaaaatgaga atagcttttg gtatgacatg      600

atgcctgcac caggagataa atttgaccaa tctaaatatt taatgatgta caatgacaat      660

aaaatggttg attctaaaga tgtgaagatt gaagtttatc ttacgacaaa gaaaaag         717


<210>  21
<211>  239
<212>  PRT
<213>  Staphylococcus aureus

<400>  21

Glu Ser Gln Pro Asp Pro Lys Pro Asp Glu Leu His Lys Ser Ser Lys 
1               5                   10                  15      


Phe Thr Gly Leu Met Glu Asn Met Lys Val Leu Tyr Asp Asp Asn His 
            20                  25                  30          


Val Ser Ala Ile Asn Val Lys Ser Ile Asp Gln Phe Leu Tyr Phe Asp 
        35                  40                  45              


Leu Ile Tyr Ser Ile Lys Asp Thr Lys Leu Gly Asn Tyr Asp Asn Val 
    50                  55                  60                  


Arg Val Glu Phe Lys Asn Lys Asp Leu Ala Asp Lys Tyr Lys Asp Lys 
65                  70                  75                  80  


Tyr Leu Asp Val Phe Gly Ala Asn Tyr Tyr Tyr Gln Cys Tyr Phe Ser 
                85                  90                  95      


Lys Lys Thr Asn Asp Ile Asn Ser His Gln Thr Asp Lys Arg Lys Thr 
            100                 105                 110         


Cys Met Tyr Gly Gly Val Thr Glu His Asn Gly Asn Gln Leu Asp Lys 
        115                 120                 125             


Tyr Arg Ser Ile Thr Val Arg Val Phe Glu Asp Gly Lys Asn Leu Leu 
    130                 135                 140                 


Ser Phe Asp Val Gln Thr Asn Lys Lys Lys Val Thr Ala Gln Glu Leu 
145                 150                 155                 160 


Asp Tyr Leu Thr Arg His Tyr Leu Val Lys Asn Lys Lys Leu Tyr Glu 
                165                 170                 175     


Phe Asn Asn Ser Pro Tyr Glu Thr Gly Tyr Ile Lys Phe Ile Glu Asn 
            180                 185                 190         


Glu Asn Ser Phe Trp Tyr Asp Met Met Pro Ala Pro Gly Asp Lys Phe 
        195                 200                 205             


Asp Gln Ser Lys Tyr Leu Met Met Tyr Asn Asp Asn Lys Met Val Asp 
    210                 215                 220                 


Ser Lys Asp Val Lys Ile Glu Val Tyr Leu Thr Thr Lys Lys Lys 
225                 230                 235                 


<210>  22
<211>  717
<212>  DNA
<213>  Staphylococcus aureus

<400>  22
gagagtcaac cagatcctaa accagatgag ttgcacaaat cgagtaaatt cactggtttg       60

atggaaaata tgaaagtttt gtatgatgat aatcatgtat cagcaataaa cgttaaatct      120

atagatcaat ttctatactt tgacttaata tattctatta aggacactaa gttagggaat      180

tatgataatg ttcgagtcga atttaaaaac aaagatttag ctgataaata caaagataaa      240

tacttagatg tgtttggagc taattattat tatcaatgtt atttttctaa aaaaacgaat      300

gatattaatt cgcatcaaac tgacaaacga aaaacttgta tgtatggtgg tgtaactgag      360

cataatggaa accaattaga taaatataga agtattactg ttcgggtatt tgaagatggt      420

aaaaatttat tatcttttga cgtacaaact aataagaaaa aggtgactgc tcaagaatta      480

gattacctaa ctcgtcacta tttggtgaaa aataaaaaac tctatgaatt taacaactcg      540

ccttatgaaa cgggatatat taaatttata gaaaatgaga atagcttttg gtatgacatg      600

atgcctgcac caggagataa atttgaccaa tctaaatatt taatgatgta caatgacaat      660

aaaatggttg attctaaaga tgtgaagatt gaagtttatc ttacgacaaa gaaaaag         717


<210>  23
<211>  239
<212>  PRT
<213>  Staphylococcus aureus

<400>  23

Glu Ser Gln Pro Asp Pro Lys Pro Asp Glu Leu His Lys Ser Ser Lys 
1               5                   10                  15      


Phe Thr Gly Leu Met Glu Asn Met Lys Val Leu Tyr Asp Asp Asn His 
            20                  25                  30          


Val Ser Ala Ile Asn Val Lys Ser Ile Asp Gln Phe Leu Tyr Phe Asp 
        35                  40                  45              


Leu Ile Tyr Ser Ile Lys Asp Thr Lys Leu Gly Asn Tyr Asp Asn Val 
    50                  55                  60                  


Arg Val Glu Phe Lys Asn Lys Asp Leu Ala Asp Lys Tyr Lys Asp Lys 
65                  70                  75                  80  


Tyr Val Asp Val Phe Gly Ala Asn Tyr Tyr Tyr Gln Cys Tyr Phe Ser 
                85                  90                  95      


Lys Lys Thr Asn Asp Ile Asn Ser His Gln Thr Asp Lys Arg Lys Thr 
            100                 105                 110         


Cys Met Tyr Gly Gly Val Thr Glu His Asn Gly Asn Gln Leu Asp Lys 
        115                 120                 125             


Tyr Arg Ser Ile Thr Val Arg Val Phe Glu Asp Gly Glu Asn Leu Leu 
    130                 135                 140                 


Ser Phe Asp Val Gln Thr Asn Lys Lys Lys Val Thr Ala Gln Glu Leu 
145                 150                 155                 160 


Asp Tyr Leu Thr Arg His Tyr Leu Val Lys Asn Lys Lys Leu Tyr Glu 
                165                 170                 175     


Phe Asn Asn Ser Pro Tyr Glu Thr Gly Tyr Ile Lys Phe Ile Glu Asn 
            180                 185                 190         


Glu Asn Ser Phe Trp Tyr Asp Met Met Pro Ala Pro Gly Asp Lys Phe 
        195                 200                 205             


Asp Gln Ser Lys Tyr Leu Met Met Tyr Asn Asp Asn Lys Met Val Asp 
    210                 215                 220                 


Ser Lys Asp Val Lys Ile Glu Val Tyr Leu Thr Thr Lys Lys Lys 
225                 230                 235                 


<210>  24
<211>  717
<212>  DNA
<213>  Staphylococcus aureus

<400>  24
gagagtcaac cagatcctaa accagatgag ttgcacaaat cgagtaaatt cactggtttg       60

atggaaaata tgaaagtttt gtatgatgat aatcatgtat cagcaataaa cgttaaatct      120

atagatcaat ttctatactt tgacttaata tattctatta aggacactaa gttagggaat      180

tatgataatg ttcgagtcga atttaaaaac aaagatttag ctgataaata caaagataaa      240

tacgtagatg tgtttggagc taattattat tatcaatgtt atttttctaa aaaaacgaat      300

gatattaatt cgcatcaaac tgacaaacga aaaacttgta tgtatggtgg tgtaactgag      360

cataatggaa accaattaga taaatataga agtattactg ttcgggtatt tgaagatggt      420

gaaaatttat tatcttttga cgtacaaact aataagaaaa aggtgactgc tcaagaatta      480

gattacctaa ctcgtcacta tttggtgaaa aataaaaaac tctatgaatt taacaactcg      540

ccttatgaaa cgggatatat taaatttata gaaaatgaga atagcttttg gtatgacatg      600

atgcctgcac caggagataa atttgaccaa tctaaatatt taatgatgta caatgacaat      660

aaaatggttg attctaaaga tgtgaagatt gaagtttatc ttacgacaaa gaaaaag         717


<210>  25
<211>  239
<212>  PRT
<213>  Staphylococcus aureus

<400>  25

Glu Ser Gln Pro Asp Pro Lys Pro Asp Glu Leu His Lys Ser Ser Lys 
1               5                   10                  15      


Phe Thr Gly Leu Met Glu Asn Met Lys Val Leu Tyr Asp Asp Asn His 
            20                  25                  30          


Val Ser Ala Ile Asn Val Lys Ser Ile Asp Gln Phe Leu Tyr Phe Asp 
        35                  40                  45              


Leu Ile Tyr Ser Ile Lys Asp Thr Lys Leu Gly Asn Tyr Asp Asn Val 
    50                  55                  60                  


Arg Val Glu Phe Lys Asn Lys Asp Leu Ala Asp Lys Tyr Lys Asp Lys 
65                  70                  75                  80  


Tyr Val Asp Val Phe Gly Ala Asn Tyr Tyr Tyr Gln Cys Tyr Phe Ser 
                85                  90                  95      


Lys Lys Thr Asn Asp Ile Asn Ser His Gln Thr Asp Lys Arg Lys Thr 
            100                 105                 110         


Cys Met Tyr Gly Gly Val Thr Glu His Asn Gly Asn Gln Leu Asp Lys 
        115                 120                 125             


Tyr Arg Ser Ile Thr Val Arg Val Phe Glu Asp Gly Lys Asn Leu Leu 
    130                 135                 140                 


Ser Phe Asp Val Gln Ile Asn Lys Lys Lys Val Thr Ala Gln Glu Leu 
145                 150                 155                 160 


Asp Tyr Leu Thr Arg His Tyr Leu Val Lys Asn Lys Lys Leu Tyr Glu 
                165                 170                 175     


Phe Asn Asn Ser Pro Tyr Glu Thr Gly Tyr Ile Lys Phe Ile Glu Asn 
            180                 185                 190         


Glu Asn Ser Phe Trp Tyr Asp Met Met Pro Ala Pro Gly Asp Lys Phe 
        195                 200                 205             


Asp Gln Ser Lys Tyr Leu Met Met Tyr Asn Asp Asn Lys Met Val Asp 
    210                 215                 220                 


Ser Lys Asp Val Lys Ile Glu Val Tyr Leu Thr Thr Lys Lys Lys 
225                 230                 235                 


<210>  26
<211>  717
<212>  DNA
<213>  Staphylococcus aureus

<400>  26
gagagtcaac cagatcctaa accagatgag ttgcacaaat cgagtaaatt cactggtttg       60

atggaaaata tgaaagtttt gtatgatgat aatcatgtat cagcaataaa cgttaaatct      120

atagatcaat ttctatactt tgacttaata tattctatta aggacactaa gttagggaat      180

tatgataatg ttcgagtcga atttaaaaac aaagatttag ctgataaata caaagataaa      240

tacgtagatg tgtttggagc taattattat tatcaatgtt atttttctaa aaaaacgaat      300

gatattaatt cgcatcaaac tgacaaacga aaaacttgta tgtatggtgg tgtaactgag      360

cataatggaa accaattaga taaatataga agtattactg ttcgggtatt tgaagatggt      420

aaaaatttat tatcttttga cgtacaaatt aataagaaaa aggtgactgc tcaagaatta      480

gattacctaa ctcgtcacta tttggtgaaa aataaaaaac tctatgaatt taacaactcg      540

ccttatgaaa cgggatatat taaatttata gaaaatgaga atagcttttg gtatgacatg      600

atgcctgcac caggagataa atttgaccaa tctaaatatt taatgatgta caatgacaat      660

aaaatggttg attctaaaga tgtgaagatt gaagtttatc ttacgacaaa gaaaaag         717


<210>  27
<211>  239
<212>  PRT
<213>  Staphylococcus aureus

<400>  27

Glu Ser Gln Pro Asp Pro Asn Pro Asp Glu Leu His Lys Ser Ser Lys 
1               5                   10                  15      


Phe Thr Gly Leu Met Glu Asn Met Lys Val Leu Tyr Asp Asp Asn His 
            20                  25                  30          


Val Ser Ala Ile Asn Val Lys Ser Ile Asp Gln Phe Leu Tyr Phe Asp 
        35                  40                  45              


Leu Ile Tyr Ser Ile Lys Asp Thr Lys Leu Gly Asn Tyr Asp Asn Val 
    50                  55                  60                  


Arg Val Glu Phe Lys Asn Lys Asp Leu Ala Asp Lys Tyr Lys Asp Lys 
65                  70                  75                  80  


Tyr Val Asp Val Phe Gly Ala Asn Tyr Tyr Tyr Gln Cys Tyr Phe Ser 
                85                  90                  95      


Lys Lys Thr Asn Asp Ile Asn Ser His Gln Thr Asp Lys Arg Lys Thr 
            100                 105                 110         


Cys Met Tyr Gly Gly Val Thr Glu His Asn Gly Asn Gln Leu Asp Lys 
        115                 120                 125             


Tyr Arg Ser Ile Thr Val Arg Val Phe Glu Asp Gly Lys Asn Leu Leu 
    130                 135                 140                 


Ser Phe Asp Val Gln Thr Asn Lys Lys Lys Val Thr Ala Gln Glu Leu 
145                 150                 155                 160 


Asp Tyr Leu Thr Arg His Tyr Leu Val Lys Asn Lys Lys Leu Tyr Glu 
                165                 170                 175     


Phe Asn Asn Ser Pro Tyr Glu Thr Gly Tyr Ile Lys Phe Ile Glu Asn 
            180                 185                 190         


Glu Asn Ser Phe Trp Tyr Asp Met Met Pro Ala Pro Gly Asp Lys Phe 
        195                 200                 205             


Asp Gln Ser Lys Tyr Leu Met Met Tyr Asn Asp Asn Lys Met Val Asp 
    210                 215                 220                 


Ser Lys Asp Val Lys Ile Glu Val Tyr Leu Thr Thr Lys Lys Lys 
225                 230                 235                 


<210>  28
<211>  717
<212>  DNA
<213>  Staphylococcus aureus

<400>  28
gagagtcaac cagatcctaa tccagatgag ttgcacaaat cgagtaaatt cactggtttg       60

atggaaaata tgaaagtttt gtatgatgat aatcatgtat cagcaataaa cgttaaatct      120

atagatcaat ttctatactt tgacttaata tattctatta aggacactaa gttagggaat      180

tatgataatg ttcgagtcga atttaaaaac aaagatttag ctgataaata caaagataaa      240

tacgtagatg tgtttggagc taattattat tatcaatgtt atttttctaa aaaaacgaat      300

gatattaatt cgcatcaaac tgacaaacga aaaacttgta tgtatggtgg tgtaactgag      360

cataatggaa accaattaga taaatataga agtattactg ttcgggtatt tgaagatggt      420

aaaaatttat tatcttttga tgtacaaact aataagaaaa aggtgactgc tcaagaatta      480

gattacctaa ctcgtcacta tttggtgaaa aataaaaaac tctatgaatt taacaactcg      540

ccttatgaaa cgggatatat taaatttata gaaaatgaga atagcttttg gtatgacatg      600

atgcctgcac caggagataa atttgaccaa tctaaatatt taatgatgta caatgacaat      660

aaaatggttg attctaaaga tgtgaagatt gaagtttatc ttacgacaaa gaaaaag         717


<210>  29
<211>  239
<212>  PRT
<213>  Staphylococcus aureus

<400>  29

Glu Ser Gln Pro Asp Pro Lys Pro Asp Glu Leu His Lys Ser Ser Lys 
1               5                   10                  15      


Phe Thr Gly Leu Met Glu Asn Met Lys Val Leu Tyr Asp Asp Asn His 
            20                  25                  30          


Val Ser Ala Ile Asn Val Lys Ser Ile Asp Gln Phe Leu Tyr Phe Asp 
        35                  40                  45              


Leu Ile Tyr Ser Ile Lys Asp Thr Lys Leu Gly Asn Tyr Asp Asn Val 
    50                  55                  60                  


Arg Val Glu Phe Lys Asn Lys Asp Leu Ala Asp Lys Tyr Lys Asp Lys 
65                  70                  75                  80  


Tyr Val Asp Val Phe Gly Ala Asn Tyr Tyr Tyr Gln Cys Tyr Phe Ser 
                85                  90                  95      


Lys Lys Thr Asn Asp Ile Asn Ser His Gln Thr Asp Lys Arg Lys Thr 
            100                 105                 110         


Cys Met Tyr Gly Gly Val Thr Glu His Asn Gly Asn Gln Leu Asp Lys 
        115                 120                 125             


Tyr Arg Ser Ile Thr Val Arg Val Phe Glu Asp Gly Lys Asn Leu Leu 
    130                 135                 140                 


Ser Phe Asp Val Gln Thr Asn Lys Lys Lys Val Thr Ala Gln Glu Leu 
145                 150                 155                 160 


Asp Tyr Leu Thr Arg His Tyr Leu Val Lys Asn Lys Lys Leu Tyr Glu 
                165                 170                 175     


Phe Asn Asn Ser Pro Tyr Glu Thr Gly Tyr Ile Lys Phe Ile Glu Asn 
            180                 185                 190         


Glu Asn Ser Phe Trp Tyr Asp Met Met Pro Ala Pro Gly Asp Lys Phe 
        195                 200                 205             


Asp Gln Ser Lys Tyr Leu Met Met Tyr Asn Asp Asn Lys Met Val Asp 
    210                 215                 220                 


Phe Lys Asp Val Lys Ile Glu Val Tyr Leu Thr Thr Lys Lys Lys 
225                 230                 235                 


<210>  30
<211>  717
<212>  DNA
<213>  Staphylococcus aureus

<400>  30
gagagtcaac cagatcctaa accagatgag ttgcacaaat cgagtaaatt cactggtttg       60

atggaaaata tgaaagtttt gtatgatgat aatcatgtat cagcaataaa cgttaaatct      120

atagatcaat ttctatactt tgacttaata tattctatta aggacactaa gttagggaat      180

tatgataatg ttcgagtcga atttaaaaac aaagatttag ctgataaata caaagataaa      240

tacgtagatg tgtttggagc taattattat tatcaatgtt atttttctaa aaaaacgaat      300

gatattaatt cgcatcaaac tgacaaacga aaaacttgta tgtatggtgg tgtaactgag      360

cataatggaa accaattaga taaatataga agtattactg ttcgggtatt tgaagatggt      420

aaaaatttat tatcttttga cgtacaaact aataagaaaa aggtgactgc tcaagaatta      480

gattacctaa ctcgtcacta tttggtgaaa aataaaaaac tctatgaatt taacaactcg      540

ccttatgaaa cgggatatat taaatttata gaaaatgaga atagcttttg gtatgacatg      600

atgcctgcac caggagataa atttgaccaa tctaaatatt taatgatgta caatgacaat      660

aaaatggttg attttaaaga tgtgaagatt gaagtttatc ttacgacaaa gaaaaag         717


<210>  31
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant SEB

<400>  31

Glu Ser Gln Pro Asp Pro Lys Pro Asp Glu Leu His Lys Ser Ser Lys 
1               5                   10                  15      


Phe Thr Gly Leu Met Lys Val Leu Tyr Asp Asp Asn His Val Ser Ala 
            20                  25                  30          


Ile Asn Val Lys Ser Ile Asp Gln Phe Arg Tyr Phe Asp Leu Ile Tyr 
        35                  40                  45              


Ser Ile Lys Asp Thr Lys Leu Gly Asn Tyr Asp Asn Val Arg Val Glu 
    50                  55                  60                  


Phe Lys Asn Lys Asp Leu Ala Asp Lys Tyr Lys Asp Lys Tyr Val Asp 
65                  70                  75                  80  


Val Phe Gly Ala Asn Tyr Tyr Tyr Gln Cys Tyr Phe Ser Lys Lys Thr 
                85                  90                  95      


Asn Asp Ile Asn Ser His Gln Thr Asp Lys Arg Lys Thr Cys Met Tyr 
            100                 105                 110         


Gly Gly Val Thr Glu His Asn Gly Asn Gln Leu Asp Lys Tyr Arg Ser 
        115                 120                 125             


Ile Thr Val Arg Val Phe Glu Asp Gly Lys Asn Leu Leu Ser Phe Asp 
    130                 135                 140                 


Val Gln Thr Asn Lys Lys Lys Val Thr Ala Gln Glu Leu Asp Tyr Leu 
145                 150                 155                 160 


Thr Arg His Tyr Leu Val Lys Asn Lys Lys Leu Tyr Glu Phe Asn Asn 
                165                 170                 175     


Ser Pro Tyr Glu Thr Gly Tyr Ile Lys Phe Ile Glu Asn Glu Asn Ser 
            180                 185                 190         


Phe Trp Tyr Asp Met Met Pro Ala Pro Gly Asp Lys Phe Asp Gln Ser 
        195                 200                 205             


Lys Tyr Leu Met Met Tyr Asn Asp Asn Lys Met Val Asp Ser Lys Asp 
    210                 215                 220                 


Val Lys Ile Glu Val Tyr Leu Thr Thr Lys Lys Lys His Met Glu Ser 
225                 230                 235                 240 


Gln Pro Asp Pro Lys Pro Asp Glu Leu His Lys Ser Ser Lys Phe Thr 
                245                 250                 255     


Gly Leu Met Lys Val Leu Tyr Asp Asp Asn His Val Ser Ala Ile Asn 
            260                 265                 270         


Val Lys Ser Ile Asp Gln Phe Arg Tyr Phe Asp Leu Ile Tyr Ser Ile 
        275                 280                 285             


Lys Asp Thr Lys Leu Gly Asn Tyr Asp Asn Val Arg Val Glu Phe Lys 
    290                 295                 300                 


Asn Lys Asp Leu Ala Asp Lys Tyr Lys Asp Lys Tyr Val Asp Val Phe 
305                 310                 315                 320 


Gly Ala Asn Tyr Tyr Tyr Gln Cys Tyr Phe Ser Lys Lys Thr Asn Asp 
                325                 330                 335     


Ile Asn Ser His Gln Thr Asp Lys Arg Lys Thr Cys Met Tyr Gly Gly 
            340                 345                 350         


Val Thr Glu His Asn Gly Asn Gln Leu Asp Lys Tyr Arg Ser Ile Thr 
        355                 360                 365             


Val Arg Val Phe Glu Asp Gly Lys Asn Leu Leu Ser Phe Asp Val Gln 
    370                 375                 380                 


Thr Asn Lys Lys Lys Val Thr Ala Gln Glu Leu Asp Tyr Leu Thr Arg 
385                 390                 395                 400 


His Tyr Leu Val Lys Asn Lys Lys Leu Tyr Glu Phe Asn Asn Ser Pro 
                405                 410                 415     


Tyr Glu Thr Gly Tyr Ile Lys Phe Ile Glu Asn Glu Asn Ser Phe Trp 
            420                 425                 430         


Tyr Asp Met Met Pro Ala Pro Gly Asp Lys Phe Asp Gln Ser Lys Tyr 
        435                 440                 445             


Leu Met Met Tyr Asn Asp Asn Lys Met Val Asp Ser Lys Asp Val Lys 
    450                 455                 460                 


Ile Glu Val Tyr Leu Thr Thr Lys Lys Lys 
465                 470                 


<210>  32
<211>  1422
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutant SEB

<400>  32
atgatgataa tcatgtatca gcaataaacg ttaaatctat agatcaattt agatactttg       60

acttaatata ttctagagag tcaaccagat cctaaaccag atgagttgca caaatcgagt      120

aaattcactg gtttgatgaa agttttgttt aaggacacta agttagggaa ttatgataat      180

gttcgagtcg aatttaaaaa caaagattta gctgataaat acaaagataa atacgtagat      240

gtgtttggag ctaattatta ttatcaatgt tatttttcta aaaaaacgaa tgatattaat      300

tcgcatcaaa ctgacaaacg aaaaacttgt atgtatggtg gtgtaactga gcataatgga      360

aaccaattag ataaatatag aagtattact gttcgggtat ttgaagatgg taaaaattta      420

ttatcttttg acgtacaaac taataagaaa aaggtgactg ctcaagaatt agattaccta      480

actcgtcact atttggtgaa aaataaaaaa ctctatgaat ttaacaactc gccttatgaa      540

acgggatata ttaaatttat agaaaatgag aatagctttt ggtatgacat gatgcctgca      600

ccaggagata aatttgacca atctaaatat ttaatgatgt acaatgacaa taaaatggtt      660

gattctaaag atgtgaagat tgaagtttat cttacgacaa agaaaaagca tatggagagt      720

caaccagatc ctaaaccaga tgagttgcac aaatcgagta aattcactgg tttgatgaaa      780

gttttgtatg atgataatca tgtatcagca ataaacgtta aatctataga tcaatttaga      840

tactttgact taatatattc tattaaggac actaagttag ggaattatga taatgttcga      900

gtcgaattta aaaacaaaga tttagctgat aaatacaaag ataaatacgt agatgtgttt      960

ggagctaatt attattatca atgttatttt tctaaaaaaa cgaatgatat taattcgcat     1020

caaactgaca aacgaaaaac ttgtatgtat ggtggtgtaa ctgagcataa tggaaaccaa     1080

ttagataaat atagaagtat tactgttcgg gtatttgaag atggtaaaaa tttattatct     1140

tttgacgtac aaactaataa gaaaaaggtg actgctcaag aattagatta cctaactcgt     1200

cactatttgg tgaaaaataa aaaactctat gaatttaaca actcgcctta tgaaacggga     1260

tatattaaat ttatagaaaa tgagaatagc ttttggtatg acatgatgcc tgcaccagga     1320

gataaatttg accaatctaa atatttaatg atgtacaatg acaataaaat ggttgattct     1380

aaagatgtga agattgaagt ttatcttacg acaaagaaaa ag                        1422


<210>  33
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant SEB

<400>  33

Glu Ser Gln Pro Asp Pro Lys Pro Asp Glu Leu His Lys Ser Ser Lys 
1               5                   10                  15      


Phe Thr Gly Leu Met Lys Val Leu Tyr Asp Asp Asn His Val Ser Ala 
            20                  25                  30          


Ile Asn Val Lys Ser Ile Asp Gln Phe Arg Tyr Phe Asp Leu Ile Tyr 
        35                  40                  45              


Ser Ile Lys Asp Thr Lys Leu Gly Asn Tyr Asp Asn Val Arg Val Glu 
    50                  55                  60                  


Phe Lys Asn Lys Asp Leu Ala Asp Lys Tyr Lys Asp Lys Tyr Val Asp 
65                  70                  75                  80  


Val Phe Gly Ala Asn Tyr Tyr Tyr Gln Cys Tyr Phe Ser Lys Lys Thr 
                85                  90                  95      


Asn Asp Ile Asn Ser His Gln Thr Asp Lys Arg Lys Thr Cys Met Tyr 
            100                 105                 110         


Gly Gly Val Thr Glu His Asn Gly Asn Gln Leu Asp Lys Tyr Arg Ser 
        115                 120                 125             


Ile Thr Val Arg Val Phe Glu Asp Gly Lys Asn Leu Leu Ser Phe Asp 
    130                 135                 140                 


Val Gln Thr Asn Lys Lys Lys Val Thr Ala Gln Glu Leu Asp Tyr Leu 
145                 150                 155                 160 


Thr Arg His Tyr Leu Val Lys Asn Lys Lys Leu Tyr Glu Phe Asn Asn 
                165                 170                 175     


Ser Pro Tyr Glu Thr Gly Tyr Ile Lys Phe Ile Glu Asn Glu Asn Ser 
            180                 185                 190         


Phe Trp Tyr Asp Met Met Pro Ala Pro Gly Asp Lys Phe Asp Gln Ser 
        195                 200                 205             


Lys Tyr Leu Met Met Tyr Asn Asp Asn Lys Met Val Asp Ser Lys Asp 
    210                 215                 220                 


Val Lys Ile Glu Val Tyr Leu Thr Thr Lys Lys Lys Gly Thr Glu Ser 
225                 230                 235                 240 


Gln Pro Asp Pro Lys Pro Asp Glu Leu His Lys Ser Ser Lys Phe Thr 
                245                 250                 255     


Gly Leu Met Lys Val Leu Tyr Asp Asp Asn His Val Ser Ala Ile Asn 
            260                 265                 270         


Val Lys Ser Ile Asp Gln Phe Arg Tyr Phe Asp Leu Ile Tyr Ser Ile 
        275                 280                 285             


Lys Asp Thr Lys Leu Gly Asn Tyr Asp Asn Val Arg Val Glu Phe Lys 
    290                 295                 300                 


Asn Lys Asp Leu Ala Asp Lys Tyr Lys Asp Lys Tyr Val Asp Val Phe 
305                 310                 315                 320 


Gly Ala Asn Tyr Tyr Tyr Gln Cys Tyr Phe Ser Lys Lys Thr Asn Asp 
                325                 330                 335     


Ile Asn Ser His Gln Thr Asp Lys Arg Lys Thr Cys Met Tyr Gly Gly 
            340                 345                 350         


Val Thr Glu His Asn Gly Asn Gln Leu Asp Lys Tyr Arg Ser Ile Thr 
        355                 360                 365             


Val Arg Val Phe Glu Asp Gly Lys Asn Leu Leu Ser Phe Asp Val Gln 
    370                 375                 380                 


Thr Asn Lys Lys Lys Val Thr Ala Gln Glu Leu Asp Tyr Leu Thr Arg 
385                 390                 395                 400 


His Tyr Leu Val Lys Asn Lys Lys Leu Tyr Glu Phe Asn Asn Ser Pro 
                405                 410                 415     


Tyr Glu Thr Gly Tyr Ile Lys Phe Ile Glu Asn Glu Asn Ser Phe Trp 
            420                 425                 430         


Tyr Asp Met Met Pro Ala Pro Gly Asp Lys Phe Asp Gln Ser Lys Tyr 
        435                 440                 445             


Leu Met Met Tyr Asn Asp Asn Lys Met Val Asp Ser Lys Asp Val Lys 
    450                 455                 460                 


Ile Glu Val Tyr Leu Thr Thr Lys Lys Lys 
465                 470                 


<210>  34
<211>  1422
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutant SEB

<400>  34
gagagtcaac cagatcctaa accagatgag ttgcacaaat cgagtaaatt cactggtttg       60

atgaaagttt tgtatgatga taatcatgta tcagcaataa acgttaaatc tatagatcaa      120

tttagatact ttgacttaat atattctatt aaggacacta agttagggaa ttatgataat      180

gttcgagtcg aatttaaaaa caaagattta gctgataaat acaaagataa atacgtagat      240

gtgtttggag ctaattatta ttatcaatgt tatttttcta aaaaaacgaa tgatattaat      300

tcgcatcaaa ctgacaaacg aaaaacttgt atgtatggtg gtgtaactga gcataatgga      360

aaccaattag ataaatatag aagtattact gttcgggtat ttgaagatgg taaaaattta      420

ttatcttttg acgtacaaac taataagaaa aaggtgactg ctcaagaatt agattaccta      480

actcgtcact atttggtgaa aaataaaaaa ctctatgaat ttaacaactc gccttatgaa      540

acgggatata ttaaatttat agaaaatgag aatagctttt ggtatgacat gatgcctgca      600

ccaggagata aatttgacca atctaaatat ttaatgatgt acaatgacaa taaaatggtt      660

gattctaaag atgtgaagat tgaagtttat cttacgacaa agaaaaaggg taccgagagt      720

caaccagatc ctaaaccaga tgagttgcac aaatcgagta aattcactgg tttgatgaaa      780

gttttgtatg atgataatca tgtatcagca ataaacgtta aatctataga tcaatttaga      840

tactttgact taatatattc tattaaggac actaagttag ggaattatga taatgttcga      900

gtcgaattta aaaacaaaga tttagctgat aaatacaaag ataaatacgt agatgtgttt      960

ggagctaatt attattatca atgttatttt tctaaaaaaa cgaatgatat taattcgcat     1020

caaactgaca aacgaaaaac ttgtatgtat ggtggtgtaa ctgagcataa tggaaaccaa     1080

ttagataaat atagaagtat tactgttcgg gtatttgaag atggtaaaaa tttattatct     1140

tttgacgtac aaactaataa gaaaaaggtg actgctcaag aattagatta cctaactcgt     1200

cactatttgg tgaaaaataa aaaactctat gaatttaaca actcgcctta tgaaacggga     1260

tatattaaat ttatagaaaa tgagaatagc ttttggtatg acatgatgcc tgcaccagga     1320

gataaatttg accaatctaa atatttaatg atgtacaatg acaataaaat ggttgattct     1380

aaagatgtga agattgaagt ttatcttacg acaaagaaaa ag                        1422


<210>  35
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant SEB

<400>  35

Glu Ser Gln Pro Asp Pro Lys Pro Asp Glu Leu His Lys Ser Ser Lys 
1               5                   10                  15      


Phe Thr Gly Leu Met Lys Val Leu Tyr Asp Asp Asn His Val Ser Ala 
            20                  25                  30          


Ile Asn Val Lys Ser Ile Asp Gln Phe Arg Tyr Phe Asp Leu Ile Tyr 
        35                  40                  45              


Ser Ile Lys Asp Thr Lys Leu Gly Asn Tyr Asp Asn Val Arg Val Glu 
    50                  55                  60                  


Phe Lys Asn Lys Asp Leu Ala Asp Lys Tyr Lys Asp Lys Tyr Val Asp 
65                  70                  75                  80  


Val Phe Gly Ala Asn Tyr Tyr Tyr Gln Cys Tyr Phe Ser Lys Lys Thr 
                85                  90                  95      


Asn Asp Ile Asn Ser His Gln Thr Asp Lys Arg Lys Thr Cys Met Tyr 
            100                 105                 110         


Gly Gly Val Thr Glu His Asn Gly Asn Gln Leu Asp Lys Tyr Arg Ser 
        115                 120                 125             


Ile Thr Val Arg Val Phe Glu Asp Gly Lys Asn Leu Leu Ser Phe Asp 
    130                 135                 140                 


Val Gln Thr Asn Lys Lys Lys Val Thr Ala Gln Glu Leu Asp Tyr Leu 
145                 150                 155                 160 


Thr Arg His Tyr Leu Val Lys Asn Lys Lys Leu Tyr Glu Phe Asn Asn 
                165                 170                 175     


Ser Pro Tyr Glu Thr Gly Tyr Ile Lys Phe Ile Glu Asn Glu Asn Ser 
            180                 185                 190         


Phe Trp Tyr Asp Met Met Pro Ala Pro Gly Asp Lys Phe Asp Gln Ser 
        195                 200                 205             


Lys Tyr Leu Met Met Tyr Asn Asp Asn Lys Met Val Asp Ser Lys Asp 
    210                 215                 220                 


Val Lys Ile Glu Val Tyr Leu Thr Thr Lys Lys Lys Gly Gly Gly Ser 
225                 230                 235                 240 


Glu Ser Gln Pro Asp Pro Lys Pro Asp Glu Leu His Lys Ser Ser Lys 
                245                 250                 255     


Phe Thr Gly Leu Met Lys Val Leu Tyr Asp Asp Asn His Val Ser Ala 
            260                 265                 270         


Ile Asn Val Lys Ser Ile Asp Gln Phe Arg Tyr Phe Asp Leu Ile Tyr 
        275                 280                 285             


Ser Ile Lys Asp Thr Lys Leu Gly Asn Tyr Asp Asn Val Arg Val Glu 
    290                 295                 300                 


Phe Lys Asn Lys Asp Leu Ala Asp Lys Tyr Lys Asp Lys Tyr Val Asp 
305                 310                 315                 320 


Val Phe Gly Ala Asn Tyr Tyr Tyr Gln Cys Tyr Phe Ser Lys Lys Thr 
                325                 330                 335     


Asn Asp Ile Asn Ser His Gln Thr Asp Lys Arg Lys Thr Cys Met Tyr 
            340                 345                 350         


Gly Gly Val Thr Glu His Asn Gly Asn Gln Leu Asp Lys Tyr Arg Ser 
        355                 360                 365             


Ile Thr Val Arg Val Phe Glu Asp Gly Lys Asn Leu Leu Ser Phe Asp 
    370                 375                 380                 


Val Gln Thr Asn Lys Lys Lys Val Thr Ala Gln Glu Leu Asp Tyr Leu 
385                 390                 395                 400 


Thr Arg His Tyr Leu Val Lys Asn Lys Lys Leu Tyr Glu Phe Asn Asn 
                405                 410                 415     


Ser Pro Tyr Glu Thr Gly Tyr Ile Lys Phe Ile Glu Asn Glu Asn Ser 
            420                 425                 430         


Phe Trp Tyr Asp Met Met Pro Ala Pro Gly Asp Lys Phe Asp Gln Ser 
        435                 440                 445             


Lys Tyr Leu Met Met Tyr Asn Asp Asn Lys Met Val Asp Ser Lys Asp 
    450                 455                 460                 


Val Lys Ile Glu Val Tyr Leu Thr Thr Lys Lys Lys 
465                 470                 475     


<210>  36
<211>  1428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutant SEB

<400>  36
gagagtcaac cagatcctaa accagatgag ttgcacaaat cgagtaaatt caccggtttg       60

atgaaagttt tgtatgatga taatcatgta tcagcaataa acgttaaatc tatagatcaa      120

tttagatact ttgacttaat atattctatt aaggacacta agttagggaa ttatgataat      180

gttcgagtcg aatttaaaaa caaagattta gctgataaat acaaagataa atacgtagat      240

gtgtttggag ctaattatta ttatcaatgt tatttttcta aaaaaacgaa tgatattaat      300

tcgcatcaaa ctgacaaacg aaaaacttgt atgtatggtg gtgtaactga gcataatgga      360

aaccaattag ataaatatag aagtattact gttcgggtat ttgaagatgg taaaaattta      420

ttatcttttg acgtacaaac taataagaaa aaggtgactg ctcaagaatt agattaccta      480

actcgtcact atttggtgaa aaataaaaaa ctctatgaat ttaacaactc gccttatgaa      540

acgggatata ttaaatttat agaaaatgag aatagctttt ggtatgacat gatgcctgca      600

ccaggagata aatttgacca atctaaatat ttaatgatgt acaatgacaa taaaatggtt      660

gattctaaag atgtgaagat tgaagtttat cttacgacaa agaaaaaggg cggtggatcc      720

gagagtcaac cagatcctaa accagatgag ttgcacaaat cgagtaaatt cactggtttg      780

atgaaagttt tgtatgatga taatcatgta tcagcaataa acgttaaatc tatagatcaa      840

tttagatact ttgacttaat atattctatt aaggacacta agttagggaa ttatgataat      900

gttcgagtcg aatttaaaaa caaagattta gctgataaat acaaagataa atacgtagat      960

gtgtttggag ctaattatta ttatcaatgt tatttttcta aaaaaacgaa tgatattaat     1020

tcgcatcaaa ctgacaaacg aaaaacttgt atgtatggtg gtgtaactga gcataatgga     1080

aaccaattag ataaatatag aagtattact gttcgggtat ttgaagatgg taaaaattta     1140

ttatcttttg acgtacaaac taataagaaa aaggtgactg ctcaagaatt agattaccta     1200

actcgtcact atttggtgaa aaataaaaaa ctctatgaat ttaacaactc gccttatgaa     1260

acgggatata ttaaatttat agaaaatgag aatagctttt ggtatgacat gatgcctgca     1320

ccaggagata aatttgacca atctaaatat ttaatgatgt acaatgacaa taaaatggtt     1380

gattctaaag atgtgaagat tgaagtttat cttacgacaa agaaaaag                  1428


<210>  37
<211>  5
<212>  PRT
<213>  Binding region

<400>  37

Met Glu Asn Met Lys 
1               5   


<210>  38
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  binding region

<400>  38

Asp Gln Phe Leu Tyr Phe 
1               5       


