 б

<110>  ܿƣҽҩ޹˾ܿʵ޹˾ܿ⣨Ϻҽҩо޹˾

<120>  ԽSARS-CoV-2Ŀԭϵ

<130>  0093-PA-017

<160>  102

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1-2G1

<400>  1

Ser Asn Tyr Met Ser 
1               5   


<210>  2
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1-13H8

<400>  2

Ser His Ser Met Asn 
1               5   


<210>  3
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1-5H10

<400>  3

Ser Tyr Trp Ile Gly 
1               5   


<210>  4
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1-7G10

<400>  4

Ser Tyr Thr Met His 
1               5   


<210>  5
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1-8G4

<400>  5

Ser Tyr Gly Ile Ser 
1               5   


<210>  6
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1-6F12

<400>  6

Ser Ser Asn Trp Trp Ser 
1               5       


<210>  7
<211>  13
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1-8G9

<400>  7

Ser Gly Gly Ser Ile Ser Ser Gly Val Asn Tyr Trp Asn 
1               5                   10              


<210>  8
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2-13H8

<400>  8

Tyr Ile Ser Ser Arg Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2-2G1

<400>  9

Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  10
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2-5H10

<400>  10

Val Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  11
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2-7G10

<400>  11

Trp Ile Asn Ala Val Asn Gly Asn Thr Arg Tyr Ser Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2-8G4

<400>  12

Trp Ile Ser Ala Phe Asn Gly Asn Thr Asp Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  13
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2-6F12

<400>  13

Glu Ile Tyr His Phe Gly Thr Thr His Tyr Asn Pro Ser Leu Lys 
1               5                   10                  15  


<210>  14
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2-8G9

<400>  14

Tyr Ile Tyr Ser Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  15
<211>  13
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3-13H8

<400>  15

Gly His Glu Thr Ser Leu Phe Arg Ser Ser Phe Asp Asp 
1               5                   10              


<210>  16
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3-2G1

<400>  16

Gly Leu Ile Arg Gly Ile Ile Met Thr Gly Ala Phe Asp Ile 
1               5                   10                  


<210>  17
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3-5H10

<400>  17

Leu Phe Leu Trp Glu Ala Gly Pro Phe Asp Tyr 
1               5                   10      


<210>  18
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3-7G10

<400>  18

Val Lys Met Ile Pro Val Leu Gly Val Phe Thr Lys Gly Gly Trp Asp 
1               5                   10                  15      


Tyr 
    


<210>  19
<211>  22
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3-8G4

<400>  19

Asp Gly Ser Pro Phe Tyr Tyr Asp Arg Ser Gly His Tyr Thr Arg Asp 
1               5                   10                  15      


Tyr Tyr Ala Met Asp Val 
            20          


<210>  20
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3-6F12

<400>  20

Ala Arg Arg Gly Gly Asp Val Phe Glu Ile 
1               5                   10  


<210>  21
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3-8G9

<400>  21

Ser Arg Thr Val Tyr Tyr Phe Asp Asn 
1               5                   


<210>  22
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR1-13H8

<400>  22

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser 
            20                  25                  30  


<210>  23
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR1-2G1

<400>  23

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Gln Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ile 
            20                  25                  30  


<210>  24
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR1-5H10

<400>  24

Gln Val Gln Leu Gln Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 
            20                  25                  30  


<210>  25
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR1-7G10

<400>  25

Glu Val Gln Leu Leu Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  26
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR1-8G4

<400>  26

Gln Leu Gln Leu Gln Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  27
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR1-6F12

<400>  27

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser 
            20                  25                  30  


<210>  28
<211>  24
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR1-8G9

<400>  28

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val 
            20                  


<210>  29
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR2-13H82G1

<400>  29

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  30
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR2-5H10

<400>  30

Trp Val Arg Gln Met Pro Gly Arg Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  31
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR2-7G10

<400>  31

Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met Gly 
1               5                   10                  


<210>  32
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR2-8G4

<400>  32

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Ala 
1               5                   10                  


<210>  33
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR2-6F12

<400>  33

Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  34
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR2-8G9

<400>  34

Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  35
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR3-13H8

<400>  35

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Met Phe Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Val Arg 
            20                  25                  30          


<210>  36
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR3-2G1

<400>  36

Arg Phe Thr Ile Ser Arg Asp Lys Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Phe Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  37
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR3-5H10

<400>  37

Gln Val Thr Ile Ser Val Asp Lys Ser Ile Asn Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  38
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR3-7G10

<400>  38

Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Asn Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  39
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR3-8G4

<400>  39

Arg Leu Thr Met Thr Thr Asp Thr Pro Thr Thr Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  40
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR3-6F12

<400>  40

Leu Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Tyr Leu Lys 
1               5                   10                  15      


Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  41
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR3-8G9

<400>  41

Gln Val Thr Ile Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  42
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR4-13H85H107G108G9

<400>  42

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  43
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR4-8G46F12

<400>  43

Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  44
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR4-2G1

<400>  44

Trp Asp Glu Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      


<210>  45
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1-13H8

<400>  45

Thr Gly Ser Ser Ser Asp Val Gly Ser Tyr Asp Leu Val Ser 
1               5                   10                  


<210>  46
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1-2G1

<400>  46

Thr Gly Thr Ser Ser Asp Val Gly Gly Ser Asn Tyr Val Ser 
1               5                   10                  


<210>  47
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1-5H10

<400>  47

Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  48
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1-7G108G4

<400>  48

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  49
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1-8G9

<400>  49

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Phe Asp Val His 
1               5                   10                  


<210>  50
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1-6F12

<400>  50

Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr Asn Leu Val Ser 
1               5                   10                  


<210>  51
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR2-13H82G16F12

<400>  51

Glu Val Ser Lys Arg Pro Ser 
1               5           


<210>  52
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR2-5H10

<400>  52

Asp Val Ser Asp Arg Pro Ser 
1               5           


<210>  53
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR2-7G108G4

<400>  53

Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210>  54
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR2-8G9

<400>  54

Gly Asp Ser Asn Arg Pro Ser 
1               5           


<210>  55
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3-13H8

<400>  55

Cys Ser Tyr Val Gly Ser Phe Trp Leu 
1               5                   


<210>  56
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3-2G1

<400>  56

Ser Ser Tyr Ala Gly Ser Asn Asn Trp Val 
1               5                   10  


<210>  57
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3-5H10

<400>  57

Ser Ser Tyr Thr Ser Ser Asn Thr Arg Val Val 
1               5                   10      


<210>  58
<211>  13
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3-7G10

<400>  58

Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Pro Tyr Val 
1               5                   10              


<210>  59
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3-8G4

<400>  59

Gln Ser Tyr Asp Ser Ser Leu Ser Gly Tyr Val 
1               5                   10      


<210>  60
<211>  12
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3-8G9

<400>  60

Gln Ser Tyr Asp Asn Ser Leu Ser Ala Pro Tyr Val 
1               5                   10          


<210>  61
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3-6F12

<400>  61

Cys Ser Tyr Ala Gly Ser Ser Thr Pro Tyr Val 
1               5                   10      


<210>  62
<211>  22
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LFR1-13H85H107G106F12

<400>  62

Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys 
            20          


<210>  63
<211>  22
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LFR1-2G1

<400>  63

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys 
            20          


<210>  64
<211>  22
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LFR1-8G48G9

<400>  64

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys 
            20          


<210>  65
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LFR2-13H8

<400>  65

Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Phe Met Ile Tyr 
1               5                   10                  15  


<210>  66
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LFR2-2G1

<400>  66

Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Ser 
1               5                   10                  15  


<210>  67
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LFR2-5H10

<400>  67

Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr 
1               5                   10                  15  


<210>  68
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LFR2-7G10

<400>  68

Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Pro Leu Ile Tyr 
1               5                   10                  15  


<210>  69
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LFR2-8G4

<400>  69

Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Val Leu Ile Tyr 
1               5                   10                  15  


<210>  70
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LFR2-8G9

<400>  70

Trp Tyr Gln Gln Leu Pro Glu Thr Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  71
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LFR2-6F12

<400>  71

Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Ile Ile Ser 
1               5                   10                  15  


<210>  72
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LFR3-13H8

<400>  72

Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser 
1               5                   10                  15      


Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  73
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LFR3-2G1

<400>  73

Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser 
1               5                   10                  15      


Leu Thr Val Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  74
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LFR3-5H10

<400>  74

Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser 
1               5                   10                  15      


Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asn Tyr Tyr Cys 
            20                  25                  30          


<210>  75
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LFR3-7G10

<400>  75

Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser 
1               5                   10                  15      


Leu Ala Ile Ala Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  76
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LFR3-8G4

<400>  76

Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser 
1               5                   10                  15      


Leu Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu Thr Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  77
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LFR3-8G9

<400>  77

Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser 
1               5                   10                  15      


Leu Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  78
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LFR3-6F12

<400>  78

Gly Val Ser Thr Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser 
1               5                   10                  15      


Leu Thr Ile Ser Gly Leu Gln Ala Gly Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  79
<211>  13
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LFR4-13H82G17G108G48G95H10

<400>  79

Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
1               5                   10              


<210>  80
<211>  13
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LFR4-6F12

<400>  80

Phe Gly Ser Gly Thr Lys Val Thr Val Leu Gly Gln Pro 
1               5                   10              


<210>  81
<211>  122
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH-13H8

<400>  81

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Ser His 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Arg Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Met Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly His Glu Thr Ser Leu Phe Arg Ser Ser Phe Asp Asp Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  82
<211>  122
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH-2G1

<400>  82

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Gln Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ile Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Lys Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Phe Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Leu Ile Arg Gly Ile Ile Met Thr Gly Ala Phe Asp Ile Trp 
            100                 105                 110         


Asp Glu Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  83
<211>  120
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH-5H10

<400>  83

Gln Val Gln Leu Gln Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Arg Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Val Asp Lys Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Phe Leu Trp Glu Ala Gly Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  84
<211>  126
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH-7G10

<400>  84

Glu Val Gln Leu Leu Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Val Asn Gly Asn Thr Arg Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Asn Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Lys Met Ile Pro Val Leu Gly Val Phe Thr Lys Gly Gly 
            100                 105                 110         


Trp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  85
<211>  131
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH-8G4

<400>  85

Gln Leu Gln Leu Gln Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Trp Ile Ser Ala Phe Asn Gly Asn Thr Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Thr Met Thr Thr Asp Thr Pro Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ser Pro Phe Tyr Tyr Asp Arg Ser Gly His Tyr Thr 
            100                 105                 110         


Arg Asp Tyr Tyr Ala Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  86
<211>  119
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH-6F12

<400>  86

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Phe Gly Thr Thr His Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Leu Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Tyr 
65                  70                  75                  80  


Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Arg Arg Gly Gly Asp Val Phe Glu Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  87
<211>  119
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH-8G9

<400>  87

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Val Asn Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Ser Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Gln Val Thr Ile Ser Leu Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Arg Thr Val Tyr Tyr Phe Asp Asn Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  88
<211>  112
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL-13H8

<400>  88

Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Ser Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asp Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Phe 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Val Gly Ser 
                85                  90                  95      


Phe Trp Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


<210>  89
<211>  113
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL-2G1

<400>  89

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Ser 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Ser Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro 
    


<210>  90
<211>  114
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL-5H10

<400>  90

Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asn Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Asn Thr Arg Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro 
        


<210>  91
<211>  116
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL-7G10

<400>  91

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Pro 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ala Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Ser Pro Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val 
            100                 105                 110         


Leu Gly Gln Pro 
        115     


<210>  92
<211>  114
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL-8G4

<400>  92

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Val 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Thr Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro 
        


<210>  93
<211>  115
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL-8G9

<400>  93

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Phe Asp Val His Trp Tyr Gln Gln Leu Pro Glu Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asp Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Ser 
                85                  90                  95      


Leu Ser Ala Pro Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110         


Gly Gln Pro 
        115 


<210>  94
<211>  114
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL-6F12

<400>  94

Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Ser Glu Val Ser Lys Arg Pro Ser Gly Val Ser Thr Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Ser Thr Pro Tyr Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro 
        


<210>  95
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1ͨʽ

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = AspAsn

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = IleVal

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = AlaGlySer

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = GlySerTyr

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = AspPheAsnTyr

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = AspLeuTyr

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = HisSer

<400>  95

Thr Gly Xaa Ser Ser Xaa Xaa Gly Xaa Xaa Xaa Xaa Val Xaa 
1               5                   10                  


<210>  96
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1ͨʽ2

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = GlySer

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = SerTyr

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = AspAsn

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = LeuTyr

<400>  96

Thr Gly Xaa Ser Ser Asp Val Gly Xaa Xaa Xaa Xaa Val Ser 
1               5                   10                  


<210>  97
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1ͨʽ3

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = GlySer

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = SerTyr

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = LeuTyr

<400>  97

Thr Gly Thr Ser Ser Asp Val Gly Xaa Xaa Asn Xaa Val Ser 
1               5                   10                  


<210>  98
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1ͨʽ4

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = SerTyr

<400>  98

Thr Gly Thr Ser Ser Asp Val Gly Gly Xaa Asn Tyr Val Ser 
1               5                   10                  


<210>  99
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1ͨʽ5

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = PheTyr

<400>  99

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Xaa Asp Val His 
1               5                   10       



<210>  100
<211>  846
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ACE2-Fc

<400>  100

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Glu Pro Lys Ser Ser Asp Lys Thr His 
    610                 615                 620                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
625                 630                 635                 640 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                645                 650                 655     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            660                 665                 670         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        675                 680                 685             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    690                 695                 700                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
705                 710                 715                 720 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                725                 730                 735     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            740                 745                 750         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        755                 760                 765             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    770                 775                 780                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
785                 790                 795                 800 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                805                 810                 815     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            820                 825                 830         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        835                 840                 845     


<210>  101
<211>  16
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>   RBD-qF1

<400>  101
caatggttaa ggcagg                                                       16


<210>  102
<211>  18
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  RBD-qR1

<400>  102
ctcaaggtct ggatcacg                                                     18

           





