                         SEQUENCE LISTING

<110>  Ƽ޹˾
 
<120>  ɱõCAR-iNKTӦ

<130>  aaaaa

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  267
<212>  PRT
<213>  IL15Rʰ

<400>  1

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                85                  90                  95      


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
            100                 105                 110         


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
        115                 120                 125             


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
    130                 135                 140                 


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
145                 150                 155                 160 


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
                165                 170                 175     


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
            180                 185                 190         


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
        195                 200                 205             


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
    210                 215                 220                 


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
225                 230                 235                 240 


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
                245                 250                 255     


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu 
            260                 265         


<210>  2
<211>  801
<212>  DNA
<213>  IL15R DNA

<400>  2
atggctccta gaagagctag aggatgtaga actttgggcc tccctgctct cttgctgctt       60

ctgctgttga ggccgcccgc tactagagga ataacctgtc cacccccaat gtccgtcgaa      120

cacgccgata tttgggtgaa gagttattca ctgtatagcc gggaacgcta catttgtaac      180

agcggattca aacgaaaagc cggcacttcc tctttgactg agtgcgttct gaacaaagcc      240

acgaatgtcg cacactggac cacgccttca ttgaagtgta ttcgcgatcc agcactggtt      300

caccaaaggc cggctcctcc atctactgtt acaacagctg gcgtgacacc acagcctgag      360

tccctgtctc cttctgggaa ggaacccgct gcctcaagcc cttcctctaa caacaccgca      420

gctacaacag ccgcgatcgt gccaggctca cagctgatgc ctagcaaaag cccatctact      480

ggcaccactg agatctcaag ccacgaatcc tcacacggaa ccccttcaca gactactgcc      540

aagaattggg agctgactgc ttcagcaagc caccaacctc ctggagtcta ccctcagggc      600

cacagtgaca ctaccgtggc catttctaca tccaccgtgc tgctgtgtgg tctttccgcc      660

gtctctctct tggcatgtta cctgaaatca agacaaactc caccactggc cagcgtggaa      720

atggaagcta tggaggcact cccagtgacc tgggggacct cttcaagaga tgaagacttg      780

gagaattgct cccaccacct g                                                801


<210>  3
<211>  135
<212>  PRT
<213>  IL-15ʰ

<400>  3

Met Val Leu Gly Thr Ile Asp Leu Cys Ser Cys Phe Ser Ala Gly Leu 
1               5                   10                  15      


Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
            20                  25                  30          


Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
        35                  40                  45              


Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
    50                  55                  60                  


Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
65                  70                  75                  80  


His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
                85                  90                  95      


Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
            100                 105                 110         


Glu Lys Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
        115                 120                 125             


Gln Met Phe Ile Asn Thr Ser 
    130                 135 


<210>  4
<211>  405
<212>  DNA
<213>  IL-15 DNA

<400>  4
atggtccttg gaacaatcga cctctgttca tgctttagcg ccggcctgcc aaaaactgaa       60

gctaactggg taaatgtgat ttccgacctc aaaaagatcg aagacctgat tcagtctatg      120

catattgacg ctacactgta tactgaaagc gacgttcacc caagctgtaa ggtgacagct      180

atgaagtgtt tccttctgga actccaggtg attagtcttg agagcggcga cgcctccatc      240

cacgacacag tagagaatct gattattctg gctaataatt ctctgtctag caacggaaac      300

gtgactgagt cagggtgtaa agagtgtgag gagctggaga aaaagaatat aaaggaattc      360

ttgcagtcct tcgtccacat tgtgcaaatg tttattaata ccagc                      405


<210>  5
<211>  20
<212>  PRT
<213>  IL-15IL-15R linkerİ

<400>  5

Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  6
<211>  60
<212>  DNA
<213>  IL-15IL-15RlinkerDNA

<400>  6
tctggcggat caggtggagg tggttctggt ggtggttcag gaggaggagg tagtggaggt       60


<210>  7
<211>  422
<212>  PRT
<213>  IL-15-IL-15Rںϵװ

<400>  7

Met Val Leu Gly Thr Ile Asp Leu Cys Ser Cys Phe Ser Ala Gly Leu 
1               5                   10                  15      


Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
            20                  25                  30          


Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
        35                  40                  45              


Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
    50                  55                  60                  


Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
65                  70                  75                  80  


His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
                85                  90                  95      


Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
            100                 105                 110         


Glu Lys Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
        115                 120                 125             


Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Met Ala Pro Arg Arg 
145                 150                 155                 160 


Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala Leu Leu Leu Leu Leu 
                165                 170                 175     


Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr Cys Pro Pro Pro Met 
            180                 185                 190         


Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser 
        195                 200                 205             


Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr 
    210                 215                 220                 


Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His 
225                 230                 235                 240 


Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Val His 
                245                 250                 255     


Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr Ala Gly Val Thr Pro 
            260                 265                 270         


Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu Pro Ala Ala Ser Ser 
        275                 280                 285             


Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala Ile Val Pro Gly 
    290                 295                 300                 


Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly Thr Thr Glu Ile 
305                 310                 315                 320 


Ser Ser His Glu Ser Ser His Gly Thr Pro Ser Gln Thr Thr Ala Lys 
                325                 330                 335     


Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro Pro Gly Val Tyr 
            340                 345                 350         


Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile Ser Thr Ser Thr Val 
        355                 360                 365             


Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu Ala Cys Tyr Leu Lys 
    370                 375                 380                 


Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu Met Glu Ala Met Glu 
385                 390                 395                 400 


Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg Asp Glu Asp Leu Glu 
                405                 410                 415     


Asn Cys Ser His His Leu 
            420         


<210>  8
<211>  1266
<212>  DNA
<213>  IL-15-IL-15RںϵDNA

<400>  8
atggtacttg ggacaattga cctttgttcc tgtttttcag ccggtctgcc taaaactgag       60

gcaaactggg tcaatgtgat atccgacctg aagaagatcg aagacttgat acagagcatg      120

catattgatg ctaccctcta caccgaatcc gacgtgcacc caagctgtaa ggttactgct      180

atgaaatgtt ttcttctgga acttcaggtc atctctcttg agtccggaga cgcctccatc      240

cacgatactg ttgagaatct gatcattttg gctaataatt cactgagcag caacggtaat      300

gtgaccgaaa gcgggtgtaa agagtgcgaa gagctggaaa agaagaatat caaagagttc      360

ctccagtctt ttgtacatat cgtacaaatg tttattaaca cttcttcagg tggatctgga      420

gggggtggaa gtggtggtgg aagtggaggt ggcggtagtg gaggaatggc tcctagaagg      480

gcacgagggt gcagaacact gggactgcct gccttgctcc tgttgctttt gttgcgcccg      540

ccagcgacaa ggggaatcac ttgccctccc cccatgtctg ttgagcatgc cgatatctgg      600

gtgaagtctt atagtctgta cagccgggaa cggtacattt gcaatagcgg cttcaaaaga      660

aaagccggaa ctagttctct gactgaatgt gtcctgaaca aggccacaaa cgtcgcacac      720

tggacaacgc ccagtctgaa atgtattcgc gatcctgcct tggttcacca gaggccagct      780

cctccctcaa ctgtcaccac tgctggcgtg actccacagc cagagtcact gtcacccagc      840

ggtaaagagc cagccgcatc cagtccatca tctaacaaca ccgctgctac aacagcagca      900

attgtgccag gatcacaact gatgccaagc aagtcaccat ccaccggaac gacggaaatt      960

tcaagtcatg agtcctccca cggcacgccg agtcaaacca ctgctaaaaa ttgggaactg     1020

actgcatctg cttcacacca gcctccgggt gtataccctc agggacactc cgacacaact     1080

gtcgcaatta gcacatctac agttctcttg tgcgggcttt ccgccgtgtc tctgctcgca     1140

tgttatctta aatctagaca gacaccaccc cttgcctcag tggaaatgga ggccatggaa     1200

gcactccccg ttacatgggg aacttccagc cgcgacgaag atctggagaa ctgctcccac     1260

cacctg                                                                1266


<210>  9
<211>  115
<212>  PRT
<213>  GC33 ʰ

<400>  9

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Lys Trp Ile 
        35                  40                  45              


Gly Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Phe Tyr Ser Tyr Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  10
<211>  345
<212>  DNA
<213>  GC33 DNA

<400>  10
caagtgcaac tgcaacaatc cggtgccgaa ttggtaaggc caggtgctag cgtgaagctg       60

agctgtaagg caagcggcta taccttcacg gactatgaaa tgcactgggt caagcagacg      120

ccagtccatg gcttgaagtg gatcggcgca ctcgacccaa agaccgggga taccgcatac      180

tcccaaaaat tcaaagggaa agccacactg accgctgata agagtagctc tactgcctat      240

atggagttga gatctctcac ctctgaggat tccgcggtgt attactgcac acggttttac      300

agctacactt actggggtca gggaactctc gttaccgtgt ctgcc                      345


<210>  11
<211>  114
<212>  PRT
<213>  GC33 ʰ

<400>  11

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gly Ile 
        35                  40                  45              


Asn Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly 
    50                  55                  60                  


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
65                  70                  75                  80  


Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser 
                85                  90                  95      


Gln Asn Thr His Val Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu 
            100                 105                 110         


Ile Lys 
        


<210>  12
<211>  342
<212>  DNA
<213>  GC33 DNA

<400>  12
gatgtcgtga tgacgcaaac ccctttgagc ctgcctgttt cccttgggga ccaggcttcc       60

atttcttgta ggtcttccca gtctctggtt cactctaatg gcaataccta cctccactgg      120

tatctccaga aacctggggg gattaattca ccaaaattgc tgatctacaa ggtgagcaat      180

cgcttctccg gtgtcccaga ccggttttca ggctctggtt cagggaccga cttcacactc      240

aagatttcac gggtagaggc agaggacctg ggagtctact tctgctctca gaacacacat      300

gtgcctccaa cattcggctc tgggaccaag ctggaaataa ag                         342


<210>  13
<211>  244
<212>  PRT
<213>  GC33 ScFv

<400>  13

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Lys Trp Ile 
        35                  40                  45              


Gly Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Phe Tyr Ser Tyr Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser 
    130                 135                 140                 


Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val 
145                 150                 155                 160 


His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly 
                165                 170                 175     


Gly Ile Asn Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 
            180                 185                 190         


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe 
    210                 215                 220                 


Cys Ser Gln Asn Thr His Val Pro Pro Thr Phe Gly Ser Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210>  14
<211>  732
<212>  DNA
<213>  GC33 ScFv DNA

<400>  14
caagtgcaac tgcaacaatc cggtgccgaa ttggtaaggc caggtgctag cgtgaagctg       60

agctgtaagg caagcggcta taccttcacg gactatgaaa tgcactgggt caagcagacg      120

ccagtccatg gcttgaagtg gatcggcgca ctcgacccaa agaccgggga taccgcatac      180

tcccaaaaat tcaaagggaa agccacactg accgctgata agagtagctc tactgcctat      240

atggagttga gatctctcac ctctgaggat tccgcggtgt attactgcac acggttttac      300

agctacactt actggggtca gggaactctc gttaccgtgt ctgccggcgg gggcggatca      360

ggcggcgggg gatccggagg cggaggatcc gatgtcgtga tgacgcaaac ccctttgagc      420

ctgcctgttt cccttgggga ccaggcttcc atttcttgta ggtcttccca gtctctggtt      480

cactctaatg gcaataccta cctccactgg tatctccaga aacctggggg gattaattca      540

ccaaaattgc tgatctacaa ggtgagcaat cgcttctccg gtgtcccaga ccggttttca      600

ggctctggtt cagggaccga cttcacactc aagatttcac gggtagaggc agaggacctg      660

ggagtctact tctgctctca gaacacacat gtgcctccaa cattcggctc tgggaccaag      720

ctggaaataa ag                                                          732


<210>  15
<211>  21
<212>  PRT
<213>  CD8źİ

<400>  15

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  16
<211>  63
<212>  DNA
<213>  CD8źDNA

<400>  16
atggcgcttc ctgtcactgc acttttgctg ccactggctt tgcttcttca tgccgcaaga       60

ccc                                                                     63


<210>  17
<211>  21
<212>  PRT
<213>  ICOSĤ

<400>  17

Phe Trp Leu Pro Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu 
1               5                   10                  15      


Gly Cys Ile Leu Ile 
            20      


<210>  18
<211>  63
<212>  DNA
<213>  ICOSĤDNA

<400>  18
ttctggcttc cgattggctg cgctgccttt gtggtagtgt gcattctcgg gtgcatactg       60

atc                                                                     63


<210>  19
<211>  21
<212>  PRT
<213>  CD8Ĥ

<400>  19

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210>  20
<211>  63
<212>  DNA
<213>  CD8ĤDNA

<400>  20
atttatattt gggctccctt ggccggcaca tgcggagttc ttctgctgag cctggtcatt       60

acc                                                                     63


<210>  21
<211>  45
<212>  PRT
<213>  CD8

<400>  21

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  22
<211>  135
<212>  DNA
<213>  CD8DNA

<400>  22
acaactacac ctgcccctag acctcccaca ccagcaccaa caattgcatc tcagccgctg       60

tcactgcgac cagaggcatg cagaccagcc gctggtggcg ctgttcatac cagaggattg      120

gacttcgcat gcgat                                                       135


<210>  23
<211>  41
<212>  PRT
<213>  CD28̼򰱻

<400>  23

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  24
<211>  123
<212>  DNA
<213>  CD28̼DNA

<400>  24
cgcagcaaac ggtctcgact gttgcactct gattatatga atatgacacc ccgaagacct       60

ggccccacaa gaaagcacta tcagccatac gctcccccaa gagactttgc cgcttatagg      120

tcc                                                                    123


<210>  25
<211>  15
<212>  PRT
<213>  linker

<400>  25

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  26
<211>  45
<212>  DNA
<213>  linker DNA

<400>  26
ggcgggggcg gatcaggcgg cgggggatcc ggaggcggag gatcc                       45


<210>  27
<211>  42
<212>  PRT
<213>  4-1BB̼򰱻

<400>  27

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  28
<211>  126
<212>  DNA
<213>  4-1BB̼DNA

<400>  28
aaacgaggca gaaagaaact cctgtatatc ttcaagcagc cctttatgag accagtccaa       60

accacccagg aggaagacgg ctgctcttgt aggttcccgg aggaagaaga gggtggatgc      120

gaactg                                                                 126


<210>  29
<211>  8
<212>  PRT
<213>  ICD1

<400>  29

Val Gln Pro Glu Glu Glu Glu Asp 
1               5               


<210>  30
<211>  24
<212>  DNA
<213>  ICD1 DNA

<400>  30
gttcaacctg aggaagaaga agat                                              24


<210>  31
<211>  8
<212>  PRT
<213>  ICD2

<400>  31

Arg Phe Thr Thr Gln Glu Glu Gly 
1               5               


<210>  32
<211>  24
<212>  DNA
<213>  ICD2 DNA

<400>  32
agattcacaa cccaggagga ggga                                              24


<210>  33
<211>  8
<212>  PRT
<213>  ICD3

<400>  33

Arg Thr Pro Glu Glu Glu Glu Gln 
1               5               


<210>  34
<211>  24
<212>  DNA
<213>  ICD3 DNA

<400>  34
cgaacccccg aagaggagga gcag                                              24


<210>  35
<211>  113
<212>  PRT
<213>  CD3ưź򰱻

<400>  35

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  36
<211>  339
<212>  DNA
<213>  CD3ưźDNA

<400>  36
agggtaaaat tctccagaag tgcagatgcc cccgcttatc agcagggcca aaatcagctc       60

tataatgaac tgaatcttgg gcgccgcgag gaatacgatg tgctcgacaa acgacggggt      120

cgcgatccag aaatgggagg caagcctcag aggcgcaaga acccgcagga aggactctac      180

aatgagttgc agaaggacaa gatggcagaa gcatacagtg agattgggat gaaaggcgaa      240

aggaggaggg gaaaggggca tgatgggttg tatcagggct tgtctactgc tacaaaggac      300

acgtatgacg cactccacat gcaggctctg cccccaaga                             339


<210>  37
<211>  323
<212>  DNA
<213>  pGK300 DNA

<400>  37
acccctctcc agccactaag ccagttgctc cctcggctga cggctgcacg cgaggcctcc       60

gaacgtctta cgccttgtgg cgcgcccgtc cttgtcccgg ggtgtgatgg cggggtgtgg      120

ggcggagggc gtggcgggga agggccggcg acgagagccg cgcgggacga ctcgtcggcg      180

ataaccggtg tcgggtagcg ccagccgcgc gacggtaacg agggaccgcg acaggcagac      240

gctcccatga tcactctgca cgccgaaggc aaatagtgca ggccgtgcgg cgcttggcgt      300

tccttggaag ggctgaatcc ccg                                              323


<210>  38
<211>  18
<212>  PRT
<213>  T2A

<400>  38

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  39
<211>  54
<212>  DNA
<213>  T2A DNA

<400>  39
gagggcagag gaagtctgct aacatgcggt gacgtcgagg agaatcctgg ccca             54


<210>  40
<211>  6217
<212>  DNA
<213>  pLV300DNA

<400>  40
acgcgtgtag tcttatgcaa tactcttgta gtcttgcaac atggtaacga tgagttagca       60

acatgcctta caaggagaga aaaagcaccg tgcatgccga ttggtggaag taaggtggta      120

cgatcgtgcc ttattaggaa ggcaacagac gggtctgaca tggattggac gaaccactga      180

attgccgcat tgcagagata ttgtatttaa gtgcctagct cgatacaata aacgggtctc      240

tctggttaga ccagatctga gcctgggagc tctctggcta actagggaac ccactgctta      300

agcctcaata aagcttgcct tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact      360

ctggtaacta gagatccctc agaccctttt agtcagtgtg gaaaatctct agcagtggcg      420

cccgaacagg gacctgaaag cgaaagggaa accagagctc tctcgacgca ggactcggct      480

tgctgaagcg cgcacggcaa gaggcgaggg gcggcgactg gtgagtacgc caaaaatttt      540

gactagcgga ggctagaagg agagagatgg gtgcgagagc gtcagtatta agcgggggag      600

aattagatcg cgatgggaaa aaattcggtt aaggccaggg ggaaagaaaa aatataaatt      660

aaaacatata gtatgggcaa gcagggagct agaacgattc gcagttaatc ctggcctgtt      720

agaaacatca gaaggctgta gacaaatact gggacagcta caaccatccc ttcagacagg      780

atcagaagaa cttagatcat tatataatac agtagcaacc ctctattgtg tgcatcaaag      840

gatagagata aaagacacca aggaagcttt agacaagata gaggaagagc aaaacaaaag      900

taagaccacc gcacagcaag cggccactga tcttcagacc tggaggagga gatatgaggg      960

acaattggag aagtgaatta tataaatata aagtagtaaa aattgaacca ttaggagtag     1020

cacccaccaa ggcaaagaga agagtggtgc agagagaaaa aagagcagtg ggaataggag     1080

ctttgttcct tgggttcttg ggagcagcag gaagcactat gggcgcagcc tcaatgacgc     1140

tgacggtaca ggccagacaa ttattgtctg gtatagtgca gcagcagaac aatttgctga     1200

gggctattga ggcgcaacag catctgttgc aactcacagt ctggggcatc aagcagctcc     1260

aggcaagaat cctggctgtg gaaagatacc taaaggatca acagctcctg gggatttggg     1320

gttgctctgg aaaactcatt tgcaccactg ctgtgccttg gaatgctagt tggagtaata     1380

aatctctgga acagattgga atcacacgac ctggatggag tgggacagag aaattaacaa     1440

ttacacaagc ttaatacact ccttaattga agaatcgcaa aaccagcaag aaaagaatga     1500

acaagaatta ttggaattag ataaatgggc aagtttgtgg aattggttta acataacaaa     1560

ttggctgtgg tatataaaat tattcataat gatagtagga ggcttggtag gtttaagaat     1620

agtttttgct gtactttcta tagtgaatag agttaggcag ggatattcac cattatcgtt     1680

tcagacccac ctcccaaccc cgaggggacc cgacaggccc gaaggaatag aagaagaagg     1740

tggagagaga gacagagaca gatccattcg attagtgaac ggatctcgac ggtatcggtt     1800

aacttttaaa agaaaagggg ggattggggg gtacagtgca ggggaaagaa tagtagacat     1860

aatagcaaca gacatacaaa ctaaagaatt acaaaaacaa attacaaaat tcaaaatttt     1920

atcgatagat acgaattaat tctaccaccc ctctccagcc actaagccag ttgctccctc     1980

ggctgacggc tgcacgcgag gcctccgaac gtcttacgcc ttgtggcgcg cccgtccttg     2040

tcccggggtg tgatggcggg gtgtggggcg gagggcgtgg cggggaaggg ccggcgacga     2100

gagccgcgcg ggacgactcg tcggcgataa ccggtgtcgg gtagcgccag ccgcgcgacg     2160

gtaacgaggg accgcgacag gcagacgctc ccatgatcac tctgcacgcc gaaggcaaat     2220

agtgcaggcc gtgcggcgct tggcgttcct tggaagggct gaatccccga cggatccgct     2280

agcgtttaaa cgcggccgcg aattcgtcga caatcaacct ctggattaca aaatttgtga     2340

aagattgact ggtattctta actatgttgc tccttttacg ctatgtggat acgctgcttt     2400

aatgcctttg tatcatgcta ttgcttcccg tatggctttc attttctcct ccttgtataa     2460

atcctggttg ctgtctcttt atgaggagtt gtggcccgtt gtcaggcaac gtggcgtggt     2520

gtgcactgtg tttgctgacg caacccccac tggttggggc attgccacca cctgtcagct     2580

cctttccggg actttcgctt tccccctccc tattgccacg gcggaactca tcgccgcctg     2640

ccttgcccgc tgctggacag gggctcggct gttgggcact gacaattccg tggtgttgtc     2700

ggggaaatca tcgtcctttc cttggctgct cgcctgtgtt gccacctgga ttctgcgcgg     2760

gacgtccttc tgctacgtcc cttcggccct caatccagcg gaccttcctt cccgcggcct     2820

gctgccggct ctgcggcctc ttccgcgtct tcgccttcgc cctcagacga gtcggatctc     2880

cctttgggcc gcctccccgc ctggtacctt taagaccaat gacttacaag gcagctgtag     2940

atcttagcca ctttttaaaa gaaaaggggg gactggaagg gctaattcac tcccaacgaa     3000

aataagatct gctttttgct tgtactgggt ctctctggtt agaccagatc tgagcctggg     3060

agctctctgg ctaactaggg aacccactgc ttaagcctca ataaagcttg ccttgagtgc     3120

ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc ctcagaccct     3180

tttagtcagt gtggaaaatc tctagcagta gtagttcatg tcatcttatt attcagtatt     3240

tataacttgc aaagaaatga atatcagaga gtgagaggaa cttgtttatt gcagcttata     3300

atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc     3360

attctagttg tggtttgtcc aaactcatca atgtatctta tcatgtctgg ctctagctat     3420

cccgccccta actccgccca gttccgccca ttctccgccc catggctgac taattttttt     3480

tatttatgca gaggccgagg ccgcctcggc ctctgagcta ttccagaagt agtgaggagg     3540

cttttttgga ggcctagact tttgcagaga cggcccaaat tcgtaatcat ggtcatagct     3600

gtttcctgtg tgaaattgtt atccgctcac aattccacac aacatacgag ccggaagcat     3660

aaagtgtaaa gcctggggtg cctaatgagt gagctaactc acattaattg cgttgcgctc     3720

actgcccgct ttccagtcgg gaaacctgtc gtgccagctg cattaatgaa tcggccaacg     3780

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     3840

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     3900

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc     3960

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     4020

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     4080

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     4140

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     4200

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     4260

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     4320

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     4380

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaaggacagt     4440

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     4500

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     4560

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     4620

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     4680

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     4740

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     4800

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt     4860

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     4920

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     4980

cgcctccatc cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     5040

tagtttgcgc aacgttgttg ccattgctac aggcatcgtg gtgtcacgct cgtcgtttgg     5100

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     5160

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     5220

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     5280

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     5340

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat accgcgccac atagcagaac     5400

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     5460

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     5520

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     5580

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat attattgaag     5640

catttatcag ggttattgtc tcatgagcgg atacatattt gaatgtattt agaaaaataa     5700

acaaataggg gttccgcgca catttccccg aaaagtgcca cctgacgtct aagaaaccat     5760

tattatcatg acattaacct ataaaaatag gcgtatcacg aggccctttc gtctcgcgcg     5820

tttcggtgat gacggtgaaa acctctgaca catgcagctc ccggagacgg tcacagcttg     5880

tctgtaagcg gatgccggga gcagacaagc ccgtcagggc gcgtcagcgg gtgttggcgg     5940

gtgtcggggc tggcttaact atgcggcatc agagcagatt gtactgagag tgcaccatat     6000

gcggtgtgaa ataccgcaca gatgcgtaag gagaaaatac cgcatcaggc gccattcgcc     6060

attcaggctg cgcaactgtt gggaagggcg atcggtgcgg gcctcttcgc tattacgcca     6120

gctggcgaaa gggggatgtg ctgcaaggcg attaagttgg gtaacgccag ggttttccca     6180

gtcacgacgt tgtaaaacga cggccagtgc caagctg                              6217


