                         SEQUENCE LISTING

<110>  Trianni, Inc.
 
<120>  HEAVY CHAIN-ONLY ANTIBODIES

<130>  TI108EP

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  2182
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide

<400>  1
agtcagcttc tgatggaatt agaacttggc aaaacaatac tgagaatgaa gtgtatgtgg       60

aacagaggct gctgatctcg ttcttcaggc tatgaaactg acacatttgg aaaccacagt      120

acttagaacc acaaagtggg aatcaagaga aaaacaatga tcccacgaga gatctataga      180

tctatagatc atgagtggga ggaatgagct ggcccttaat ttggttttgc ttgtttaaat      240

tatgatatcc aactatgaaa cattatcata aagcaatagt aaagagcctt cagtaaagag      300

caggcattta tctaatccca ccccaccccc acccccgtag ctccaatcct tccattcaaa      360

atgtaggtac tctgttctca cccttcttaa caaagtatga caggaaaaac ttccatttta      420

gtggacatct ttattgttta atagatcatc aatttctgca gacttacagg acggatcgat      480

cccctcagtt agcctccccc atctcccggg caaacgtgcg cgccaggtcg catatcgtcg      540

gtatggagcc gggggtggtg acgtgggtct ggaccatccc ggaggtaagt tgcagcaggg      600

cgtcccggca gccggcgggc gattggtcgt aatccaggat aaagacgtgc atggaacgga      660

ggcgtttggc caagacgtcc aaggcccagg caaacacgtt atacaggtcg ccgttggggg      720

ccagcaactc gggggcccga aacagggtaa ataacgtgtc cccgatatgg ggtcgtgggc      780

ccgcgttgct ctggggctcg gcaccctggg gcggcacggc cgtccccgaa agctgtcccc      840

agtcctcccg ccacgacccg ccgcactgca gataccgcac cgtattggca agtagcccgt      900

aaacgcggcg aatcgcagcc agcatagcca ggtccagccg ctcgccgggg cgctggcgtt      960

tggccaggcg gtcgatgtgt ctgtcctccg gaagggcccc aagcacgatg ttggtgccgg     1020

gcaaggtcgg cgggatgagg gccacgaacg ccagcacggc ctggggggtc atgctgccca     1080

taaggtaccg cgcggccggg tagcacagga gggcggcgat gggatggcgg tcgaagatga     1140

gggtgagggc cgggggcggg gcatgtgagc tcccagcctc ccccccgata tgaggagcca     1200

gaacggcgtc ggtcacggca taaggcatgc ccattgttat ctgggcgctt gtcattacca     1260

ccgccgcgtc cccggccgat atctcaccct ggtcgaggcg gtgttgtgtg gtgtagatgt     1320

tcgcgattgt ctcggaagcc cccagcaccc gccagtaagt catcggctcg ggtacgtaga     1380

cgatatcgtc gcgcgaaccc agggccacca gcagttgcgt ggtggtggtt ttccccatcc     1440

cgtggggacc gtctatataa acccgcagta gcgtgggcat tttctgctcc gggcggactt     1500

ccgtggcttc ttgctgccgg cgagggcgca acgccgtacg tcggttgcta tggccgcgag     1560

aacgcgcagc ctggtcgaac gcagacgcgt gttgatggcc ggggtacgag gccatgatgg     1620

caaggacggt gcattggctg caggtcgaaa ggcccggaga tgaggaagag gagaacagcg     1680

cggcagacgt gcgcttttga agcgtgcaga atgccgggcc tccggaggac cttcgggcgc     1740

ccgccccgcc cctgagcccg cccctgagcc cgcccccgga cccacccctt cccagcctct     1800

gagcccagaa agcgaaggag caaagctgct attggccgct gccccaaagg cctacccgct     1860

tccattgctc agcggtgctg tccatctgca cgagactagt gagacgtgct acttccattt     1920

gtcacgtcct gcacgacgcg agctgcgggg cgggggggaa cttcctgact aggggaggag     1980

tagaaggtgg cgcgaagggg ccaccaaaga acggagccgg ttggcgccta ccggtggatg     2040

tggaatgtgt gcgaggccag aggccacttg tgtagcgcca agtgcccagc ggggctgcta     2100

aagcgcatgc tccagactgc cttgggaaaa gcgcctcccc tacccggtag aattgacctg     2160

ccggggccct cgaatcctgc ag                                              2182


<210>  2
<211>  2369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide

<400>  2
aggtgctcag caaaggaggt cggcaggagg gcggagggtg tgtttttgta tgggagaagc       60

aggagggcag aggctgtggg tttttgttat aggaacagag gcagaacaga cactgtgcta      120

ctggtacttc gatctctggg gccgtggcac cctggtcact gtctcctcag gtaagctggc      180

ttttttcttt ctgcacattc cattctgaaa cgggaaaaga tattctcaga tctccccatg      240

tcaggccatc tgccacactg tgagtcctgc atctggggac tgtggggttc aggtggccta      300

aggcaggatg tggagaggtt tttgttcggg gaacagaggg gtatccaaca ctgtgtgatg      360

cttttgatat ctggggccaa gggacaatgg tcaccgtctc ttcaggtaag atggctttcc      420

ttctgcctcc tttctctggg cccagcgtcc tctgtcctgg agctgggaga taatgtccgg      480

gggctccttg gtctgcgctg ggccatgtgg ggccctccgg ggctccttct ccggctgtct      540

gcatgctgca gaagcttttc tgtaaggata gggtcttcac tcccaggaaa agaggcagtc      600

agaggctagc tgcctgtgga acagtgacaa tcatggaaaa taggcattta cattgttagg      660

ctacatgggt agatgggttt ttgtacaccc actaaagggg tctatgacac tgtgactact      720

ttgactactg gggccaggga accctggtca ccgtctcctc aggtgagtcc ttacaacctc      780

tctcttctat tcagcttaaa tagattttac tgcatttgtt gggggggaaa tgtgtgtatc      840

tgaatttcag gtcatgaagg actagggaca ccttgggagt cagaaagggt cattgggagc      900

cctggctgac gcagacagac atcctcagct cccatacttc atggccagag atttataggg      960

atcctggcca gcattgccgc taggtccctc tcttctatgc tttctttgtc cctcactggc     1020

ctccatctga gatcatcctg gagccctagc caaggatcgg tttttgtcag gggtctaatc     1080

attgttgtca cactgtgaca actggttcga cccctggggc cagggaaccc tggtcaccgt     1140

ctcctcaggt gagtcctaac ttctcccatt ctaaatgcat gttgggggga ttctgggcct     1200

tcaggaccaa gattctctgc aaacgggaat caagattcaa cccctttgtc ccaaagttga     1260

gacatgggtc tgggtcaggg actctctgcc tgctggtctg tggtgacatt agaactgaag     1320

tatgatgaag gatctgccag aactgaagct tgaagtctga ggcagaatct tgtccagggt     1380

ctatcggact cttgtgagaa ttaggggctg acagttgatg gtgacaattt cagggtcagt     1440

gactgtctgg tttctctgag gtgaggctgg aatataggtc accttgaaga ctaaagaggg     1500

gtccaggggc ttctgcacag gcagggaaca gaatgtggaa caatgacttg aatggttgat     1560

tcttgtgtga caccaggaat tggcataatg tctgagttgc ccaggggtga ttctagtcag     1620

actctgggtt tttgttcggg tatagaggaa aaatccacca ctgtgattac tactactact     1680

actacatgga cgtctggggc aaagggacca cggtcaccgt ctcctcaggt aagaatggcc     1740

tctccaggtc tttattttta acctttgtta tggagttttc tgagcattgc agactaatct     1800

tggatatttg tccctgaggg agccggctga gagaagttgg gaaataaact gtctagggat     1860

ctcagagcct ttaggacaaa cggtggctgc cgtcctgaca ggggcttagg gaggctccag     1920

gacctcagtg ccttgaagct ggtttccaag agaaaaggat tgtttatctt aggaggcatg     1980

cttactgtta aaagacagga tatgtttgaa gtggcttctg agaaaaatgg ttaagaaaat     2040

tatgacttaa aaatgtgaga gattttcaag tatattaatt tttttaactg tccaagtatt     2100

tgaaattctt atcatttgat taacacccat gagtgatatg tgtctggaat tgaggccaaa     2160

gcaagctcag ctaagaaata ctagcacagt gctgtcggcc ccgatgcggg actgcgtttt     2220

gaccatcata aatcaagttt atttttttaa ttaattgagc gaagctggaa gcagatgatg     2280

aattagagtc aagatggctg catgggggtc tccggcaccc acagcaggtg gcaggaagca     2340

ggtcaccgcg agagtctatt ttaggaagc                                       2369


<210>  3
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide

<400>  3
cctttagtga gggttaatt                                                    19


<210>  4
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide

<400>  4
gaagttccta ttccgaagtt cctattcttc aaaaggtata ggaacttc                    48


<210>  5
<211>  2711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide

<400>  5
tcattctggc ctccccctcc cccaaggtca ttctggcctc cccctccccc aaggtcattc       60

tggcctcccc ctcccccttg gccgcgcctc attctggcct ccccctcccc caaggcacac      120

aaaaaaccaa cacacagatc tattgaaaat aatgatcttt tattgatccg cgcctggatc      180

tcgaaccggt tcaggcaccg ggcttgcggg tcatgcacca ggtgcgcggt ccttcgggca      240

cctcgacgtc ggcggtgacg gtgaagccga gccgctcgta gaaggggagg ttgcggggcg      300

cggaggtctc caggaaggcg ggcaccccgg cgcgctcggc cgcctccact ccggggagca      360

cgacggcgct gcccagaccc ttgccctggt ggtcgggcga gacgccgacg gtggccagga      420

accacgcggg ctccttgggc cggtgcggcg ccaggaggcc ttccatctgt tgctgcgcgg      480

ccagccggga accgctcaac tcggccatgc gcgggccgat ctcggcgaac accgcccccg      540

cttcgacgct ctccggcgtg gtccagaccg ccaccgcggc gccgtcgtcc gcgacccaca      600

ccttgccgat gtcgagcccg acgcgcgtga ggaagagttc ttgcagctcg gtgacccgct      660

cgatgtggcg gtccgggtcg acggtgtggc gcgtggcggg gtagtcggcg aacgcggcgg      720

cgagggtgcg tacggcccgg gggacgtcgt cgcgggtggc gaggcgcacc gtgggcttgt      780

actcggtcat ggaaggctag gcggatcggc gatcgctccg gaggccgccc tgggagtgga      840

cacctgtgga gagaaaggca aagtggatgt caatgtcact caagtgtatg gccagatctc      900

aagcctgcca cacctcaagc ttgacaacaa aaagattgtc ttttctgacc agatggacgc      960

ggccaccctc aaaggcatca ccgcgggcca ggtgaatatc aaatcctcct cgtttttgga     1020

aactgacaat cttagcgcag aagtcatgcc cgcttttgag agggagtact caccccaacg     1080

cttctagagc cgccggtcac acgccagaag ccgaaccccg ccctgccccg tcccccccga     1140

aggcagccgt ccccccgcgg acagccccga ggctggagag ggagaagggg acggcggcgc     1200

ggcgacgcac gaaggccctc cccgcccatt tccttcctgc cggcgccgca ccgcttcgcc     1260

ccgcgcccgc tagagggggt gcggcggcgc ctcccagatt tcggctccgc acagatttgg     1320

gacaaaggaa gtccctgcgc cctctcgcac gattaccata aaaggcaatg gctgcggctc     1380

gccgcgcctc gacagccgcc ggcgctccgg gggccgccgc gcccctcccc cgagccctcc     1440

ccggcccgag gcggccccgc cccgcccggc acccccacct gccgccaccc cccgcccggc     1500

acggcgagcc ccgcgccacg ccccgtacgg agccccgcac ccgaagccgg gccgtgctca     1560

gcaactcggg gaggggggtg cagggggggt tgcagcccga ccgacgcgcc cacaccccct     1620

gctcaccccc ccacgcacac accccgcacg cagcctttgt tcccctcgca gccccccccg     1680

caccgcgggg caccgccccc ggccgcgctc ccctcgcgca cactgcggag cgcacaaagc     1740

cccgcgccgc gcccgcagcg ctcacagccg ccgggcagcg cggagccgca cgcggcgctc     1800

cccacgcaca cacacacgca cgcacccccc gagccgctcc ccccgcacaa agggccctcc     1860

cggagcccct caaggctttc acgcagccac agaaaagaaa caagccgtca ttaaaccaag     1920

cgctaattac agcccggagg agaagggccg tcccgcccgc tcacctgtgg gagtaacgcg     1980

gtcagtcaga gccggggcgg gcggcgcgag gcggcggcgg agcggggcac ggggcgaagg     2040

cagcgcgcag cgactcccgc ccgccgcgcg cttcgctttt tatagggccg ccgccgccgc     2100

cgcctcgcca taaaaggaaa ctttcggagc gcgccgctct gattggctgc cgccgcacct     2160

ctccgcctcg ccccgccccg cccctcgccc cgccccgccc cgcctggcgc gcgccccccc     2220

cccccccgcc cccatcgctg cacaaaataa ttaaaaaata aataaataca aaattggggg     2280

tggggagggg ggggagatgg ggagagtgaa gcagaacgtg gggctcacct cgaccatggt     2340

aatagcgatg actaatacgt agatgtactg ccaagtagga aagtcccata aggtcatgta     2400

ctgggcataa tgccaggcgg gccatttacc gtcattgacg tcaatagggg gcgtacttgg     2460

catatgatac acttgatgta ctgccaagtg ggcagtttac cgtaaatact ccacccattg     2520

acgtcaatgg aaagtcccta ttggcgttac tatgggaaca tacgtcatta ttgacgtcaa     2580

tgggcggggg tcgttgggcg gtcagccagg cgggccattt accgtaagtt atgtaacgcg     2640

gaactccata tatgggctat gaactaatga ccccgtaatt gattactatt aataactagt     2700

caataatcaa t                                                          2711


<210>  6
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide

<400>  6
gaagttccta ttccgaagtt cctattcttc aaaaggtata ggaacttc                    48


<210>  7
<211>  313
<212>  DNA
<213>  Mus musculus

<400>  7
ctgcagcagc tggcaggaag caggtcatgt ggcaaggcta tttggggaag ggaaaataaa       60

accactaggt aaacttgtag ctgtggtttg aagaagtggt tttgaaacac tctgtccagc      120

cccaccaaac cgaaagtcca ggctgagcaa aacaccacct gggtaatttg catttctaaa      180

ataagttgag gattcagccg aaactggaga ggtcctcttt taacttattg agttcaacct      240

tttaatttta gcttgagtag ttctagtttc cccaaactta agtttatcga cttctaaaat      300

gtatttagaa ttc                                                         313


<210>  8
<211>  1000
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide

<400>  8
ttaaaaaaaa aaaaaaagga aagggacttc tctgtgtttg gcaacacaag tgcgatgcac       60

aggcaggaag atcaaatctg tcccaacaat acaggggaca gagggtcaac ctacaaaagg      120

aaagaacctg gggcagtgtg aagacaacac tgtagaagcc aaggctgagt tcactgagct      180

ctcgttagtg agactacaca gcaaggaggt ggcgggcact gagcagtgag gccccgggaa      240

gtgggggtga tggtggtgac ggtggtaact gttaagaact gggggaaaga attgtggaga      300

accaagctaa atagttatgt caaaccacat gtttaggagc ctgggttgac ttcataggga      360

gtaggcatgg aggctaatct agaggtttgt gtataggcaa gaagtgaatc ctgacccaag      420

aatagagagt gctaaacgga cttagttcaa agacaactga aaaagacaat gcctgcaaaa      480

caaagctaag gccagagctc ttggactatg aagagttcag ggaacctaag aacagggacc      540

atctgtgtac aggccaaggc cggtagaagc agcctaggaa gtgtcaagag ccaacgtggc      600

tgggtgggca aagacaggaa gggactgtta ggctgcaggg atgtgccgac ttcaatgtgc      660

ttcagtattg tccagattgt gtgcagccat atggcccagg tataagaggt ttaacagtgg      720

aacacagatg cccacatcag acagctgggg ggcgggggtg aacacagata cccatactgg      780

aaagcaggtg gggcattttc ctaggaacgg gactgggctc aatggcctca ggtctcatct      840

ggtctggtga tcctgacatt gataggccca aatgttggat atcacctact ccatgtagag      900

agtcggggac atgggaaggg tgcaaaagag cggccttcta gaaggtttgg tcctgtcctg      960

tcctgtctga cagtgtaatc acatatactt tttcttgtag                           1000


<210>  9
<211>  243
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide

<400>  9
aagatcaaaa gttgttcttc tcccttctgg agatttctat gtcctttaca actcaattgg       60

ttaatatcct gggttggagt cccacacatc ttgacaaaca gagacaaatt tgagtatcac      120

cagccaaaag tcatacccaa aaacagcctg gcatgaccac acaccagact caaacttacc      180

ctacctttat cctggtggct tctcatctcc agaccccagt aacacatagc tttctctcca      240

cag                                                                    243


<210>  10
<211>  4252
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide

<400>  10
tgcccaggga ttgtggttgt aagccttgca tatgtacagg taagtcagtg gccttcacct       60

gacccagatg caacaagtgg caatgttgga gggtggccag gtattgacct atttccacct      120

ttcttcttca tccttagtcc cagaagtatc atctgtcttc atcttccccc caaagcccaa      180

ggatgtgctc accattactc tgactcctaa ggtcacgtgt gttgtggtag acatcagcaa      240

ggatgatccc gaggtccagt tcagctggtt tgtagatgat gtggaggtgc acacagctca      300

gacgcaaccc cgggaggagc agttcaacag cactttccgc tcagtcagtg aacttcccat      360

catgcaccag gactggctca atggcaagga gttcaaatgc agggtcaaca gtgcagcttt      420

ccctgccccc atcgagaaaa ccatctccaa aaccaaaggt gagagctgca gtgtgtgaca      480

tagaagctgc aatagtcagt ccatagacag agcttggcat aacagacccc tgccctgttc      540

gtgacctctg tgctgaccaa tctctttacc cacccacagg cagaccgaag gctccacagg      600

tgtacaccat tccacctccc aaggagcaga tggccaagga taaagtcagt ctgacctgca      660

tgataacaga cttcttccct gaagacatta ctgtggagtg gcagtggaat gggcagccag      720

cggagaacta caagaacact cagcccatca tgaacacgaa tggctcttac ttcgtctaca      780

gcaagctcaa tgtgcagaag agcaactggg aggcaggaaa tactttcacc tgctctgtgt      840

tacatgaggg cctgcacaac caccatactg agaagagcct ctcccactct cctggtaaat      900

gatcccagtg tccttggagc cctctggtcc tacaggactc tgacacctac ctccacccct      960

ccctgtataa ataaagcacc cagcactgcc ttgggaccct gcaataacgt cctggtgatt     1020

tctgagatgt agagtctagc taggtcatgg aatgaggggt ctccatggtt tgagccctga     1080

gttgtgacta aggaaaaact cataggccta cactgccaca cccagcactt ttgaatttgc     1140

ctgacatgaa aagaatttac ctctccctgg aaagtggagc cttatcccta ggcagttccc     1200

ttaccagacc ttcctctagc ttgcactatg ttctgggcac agaatgtgtc taacccccca     1260

aagtaaggaa gacacaacct ctacttccct cactctgtcc ttaccccttt tcctggctaa     1320

gcatctcact gagtgcgctg aatagatgca tgtggccaca gcttgcagac agacctttgc     1380

catctctccg ctcagctttc cagaggctaa gtctagcccg tatggtgatg atgcagggag     1440

ctctatgcta tctcagtgtt atcagactcc taagtggagg atcaacatgg tcccattaaa     1500

accaacctgc tcagcaacac cctgccaata aggcccgtat gtgaaaatgt gcacacatct     1560

acacatgcac aggcacacac acacacacat gcatgggcac acacacatac agagagagag     1620

aatcacagaa actcccatga gcatcctata cagtactcaa agataaaaag gtaccaggtc     1680

tacccacatg atcatcctcg gcatttacaa gtgggccaac tgatacagat aaaacttttc     1740

tatgccaagg acgccaacaa ccttcctcat atacacaagt ccgctcatga caaatctgtc     1800

cctgaacctc agactggcgc ccgtgactca cacagtggac actcctccaa agctgtatag     1860

cttcctttac ttccctgtgt gtactttctc tgaagtacac tcatcacaca gaagaggccc     1920

tgtgattact ctggccctct gttcttggtc atcagagaat agacagaaga tcaggcaaac     1980

tacacagaca cttcccacaa tcatcacagg ccctgactct gctctccagt ctcaaaactg     2040

aaggctggag cacacagaaa taagctccta cacagcccag accagtatcg ggtccagtgt     2100

gtctgaatga gcccagggac aaaatggcag cactttgggg aactgagatt tctggtccaa     2160

gaaggagaga tggaggccca gggagggtct gctgacccag cccagcccag cccagctgca     2220

gctttctcct gggcctccat gcagcttcct gccacacagg gaatggccct agccccacct     2280

tattgggaca aacactgacc gccctctctg tccagggctg caactggacg agacctgtgc     2340

tgaggcccag gacggggagc tggacgggct ctggacgacc atcaccatct tcatcagcct     2400

cttcctgctc agcgtgtgct acagcgctgc tgtcacactc ttcaaggtca gccatactgt     2460

ccccacagtg tctacaatgt cctcatactc ttccccatac tgtccctgtg gtgacctata     2520

ccccacactg tcccatgcta atgaccacag tcttacatgc tatgtaatgc tgtctaccct     2580

tctgtatgca cagtctcaca atgtcccatg cagtctccac gatgctccat gctgcccctt     2640

gttccacgct atgctgtccc atgctattgt ctgtattttc atgctctttt cacactgtcc     2700

ctagtgtcac attctgccca tgttgtccac cacattgtcc ccactctgca cacagcctca     2760

cactgtaccc tgctacccga taatgttccc tgttgtcccc aactctctcc ctgcatcatt     2820

tgtcaactgt cccctgaatt cccatgttgt tcccacactg ttagtgtgta atgtgctctg     2880

tcccaggtgt accttgttcc gtgctgtctc acttcatcgc ccattctgtc cttttactaa     2940

ccccactcta tcaccacact gtccctatgc actgcccaca ttgtcctcat actgtcccat     3000

tttgtatctt catcctgtcc ccatagtgtc caatgatcta ccccacacta ttcccacttc     3060

atgcccctac aatttcccta ttccatccct ctctggtcac catgccatcc ttcccactcc     3120

tgcacagctg gagagggact cccgggatga gtccttgccc agatgagcta cctatctaga     3180

ggagtcttca ggtgggaagg gaatgcagtc ttgatcttgg tcttattcac cctgtctcac     3240

aggtaaagtg gatcttctcc tcggtggtgg agctgaagca gacactggtt cctgaataca     3300

agaacatgat tgggcaagcg ccctaggcca cctcttgtaa tggcagggga tttcccaggc     3360

cccaaaggac cctgtccaat atgccaagca gcacaactga gatcacactg tctgctcatc     3420

tcgctttcct ccgaccccga gactcagcta ctctcaaatt ttccctctct gaaggaccat     3480

gtggacatta cattgctcca ggccacagcc accaggacct aaaacaccat cacagcagca     3540

ccaaagacac tggatagacc cacaagagca atagcttcct caacagtata tccaaactgt     3600

tgggacaaac gagcaatcac tgaagaagtg acaagttccc acaatgtcag tgtccagctg     3660

agaaggggca aaaagtggta ccagccctgt ccacaccacc ttctaattca caggaatccg     3720

tgatagaaga ggcaggttgt agatccgaaa gatgagacag attttatcaa ctccagaaag     3780

agctgggccc aactgaatct aactgaatta ttctagcgac cttggcattg ccatgacctg     3840

ccatgacctt cctccttagc acttcgatga accctgggat atggaaaatg cctgtgtttc     3900

tcagggtttg ggaagaacca tccatgttgg gattcttgtg tagatcctcc tcctggtcac     3960

agatgcaata cactggattt tcaggcaaag gagcaaattc acagacaact ctggccctac     4020

agtcctcaga cctagacacc accatctcct tggaattatc aaatctaaca cccggcacac     4080

aacaaagaag gactgggact ttgaggcctt tgtgtagccc tagagggggc agaggccact     4140

gagcagggat tgggtgatca gcaaggacct cctggagagg gacctgagga gcaggttcca     4200

attgggccaa agaaagaaga agaacaatag aggtgaagga tgctggaaag ag             4252


<210>  11
<211>  623
<212>  DNA
<213>  Homo sapiens

<400>  11
gggtggcatc cctgtgaccc ctccccagtg cctctcctgg ccctggaagt tgccactcca       60

gtgcccacca gccttgtcct aataaaatta agttgcatca ttttgtctga ctaggtgtcc      120

ttctataata ttatggggtg gaggggggtg gtatggagca aggggcaagt tgggaagaca      180

acctgtaggg cctgcggggt ctattgggaa ccaagctgga gtgcagtggc acaatcttgg      240

ctcactgcaa tctccgcctc ctgggttcaa gcgattctcc tgcctcagcc tcccgagttg      300

ttgggattcc aggcatgcat gaccaggctc agctaatttt tgtttttttg gtagagacgg      360

ggtttcacca tattggccag gctggtctcc aactcctaat ctcaggtgat ctacccacct      420

tggcctccca aattgctggg attacaggcg tgaaccactg ctcccttccc tgtccttctg      480

attttaaaat aactatacca gcaggaggac gtccagacac agcataggct acctggccat      540

gcccaaccgg tgggacattt gagttgcttg cttggcactg tcctctcatg cgttgggtcc      600

actcagtaga tgcctgttga att                                              623


<210>  12
<211>  4565
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide

<400>  12
gtgttcatgc ccctagagtt ggctgaaggg ccagatccac ctactctaga ggcatctctc       60

cctgtctgtg aaggcttcca aagtcacgtt cctgtggcta gaaggcagct ccatagccct      120

gctgcagttt cgtcctgtat accaggttca cctactacca tatctagccc tgcctgcctt      180

aagagtagca acaaggaaat agcagggtgt agagggatct cctgtctgac aggaggcaag      240

aagacagatt cttacccctc catttctctt ttatccctct ctggtcctca gagagtcagt      300

ccttcccaaa tgtcttcccc ctcgtctcct gcgagagccc cctgtctgat aagaatctgg      360

tggccatggg ctgcctggcc cgggacttcc tgcccagcac catttccttc acctgaaact      420

accagaacaa cactgaagtc atccagggta tcagaacctt cccaacactg aggacagggg      480

gcaagtacct agccacctcg caggtgttgc tgtctcccaa gagcatcctt gaaggttcag      540

atgaatacct ggtatgcaaa atccactacg gaggcaaaaa caaagatctg catgtgccca      600

ttccaggtaa gaaccaaacc ctcccagcag gggtgcccag gcccaggcat ggcccagagg      660

gagcagcggg gtggggctta ggccaagctg agctcacacc ttgacctttc attccagctg      720

tcgcagagat gaaccccaat gtaaatgtgt tcgtcccacc acgggatggc ttctctggcc      780

ctgcaccacg caagtctaaa ctcatctgcg aggccacgaa cttcactcca aaaccgatca      840

cagtatcctg actaaaggat gggaagctcg tggaatctgg cttcaccaca gatccggtga      900

ccatcgagaa caaaggatcc acaccccaaa cctacaaggt cataagcaca cttaccatct      960

ctgaaatcga ctggctgaac ctgaatgtgt acacctgccg tgtggatcac aggggtctca     1020

ccttcttgaa gaacgtgtcc tccacatgtg ctgccagtga gtggcctggg ctaagcccaa     1080

tgcctagccc tcccagatta gggaagtcct cctacaatta tggccaatgc cacccagaca     1140

tggtcatttg ctccttgaac tttggctccc cagagtggcc aaggacaaga atgagcaata     1200

ggcagtagag gggtgagaat cagctggaag gaccagcatc ttcccttaag taggtttggg     1260

ggatggagac taagcttttt tccaacttca caactagata tgtcataacc tgacacagtg     1320

ttctcttgac tgcaggtccc tccacagaca tcctaacctt caccatcccc ccctcctttg     1380

ccgacatctt cctcagcaag tccgctaacc tgacctgtct ggtctcaaac ctggcaacct     1440

atgaaaccct gaatatctcc tgagcttctc aaagtggtga accactggaa accaaaatta     1500

aaatcatgga aagccatccc aatggcacct tcagtgctaa gggtgtggct agtgtttgtg     1560

tggaagactg gaataacagg aaggaatttg tgtgtactgt gactcacagg gatctgcctt     1620

caccacagaa gaaattcatc tcaaaaccca atggtaggta tccccccttc ccttcccctc     1680

caattgcagg acccttcctg tacctcatag ggagggcagg tcctcttcca ccctatcctc     1740

actactgtct tcatttacag aggtgcacaa acatccacct gctgtgtacc tgctgccacc     1800

agctcgtgag caactgaacc tgagggagtc agccacagtc acctgcctgg tgaagggctt     1860

ctctcctgca gacatcagtg tgcagtggct tcagagaggg caactcttgc cccaagagaa     1920

gtatgtgacc agtgccccga tgccagagcc tggggcccca ggcttctact ttacccacag     1980

catcctgact gtgacagagg aggaatggaa ctccggagag acctatacct gtgttgtagg     2040

ccacgaggcc ctgccacacc tggtgaccga gaggaccgtg gacaagtcca ctggtaaacc     2100

cacactgtac aatgtctccc tgatcatgtc tgacacaggc ggcacctgct attgaccatg     2160

ctagcgctca accaggcagg ccctgggtgt ccagttgctc tgtgtatgca aactaaccat     2220

gtcagagtga gatgttgcat tttataaaaa ttagaaataa aaaaaatcca ttcaaacgtc     2280

actggttttg attatacaat gctcatgcct gctgagacag ttgtgttttg cttgctctgc     2340

acacaccctg catacttgcc tccaccctgg cccttcctct accttgccag tttcctcctt     2400

gtgtgtgaac tcagtcaggc ttacaacaga cagagtatga acatgcgatt cctccagcta     2460

cttctagata tatggctgaa agcttgccta acctggtgca ggcagcattc aggcacatat     2520

atagacacac atgcatttat acatagatat ataggtacac atgtgtagac acatacatga     2580

atgtgtattc atggacacac agacaaaggt acacatatat acacatgagt tcatgcgcac     2640

acacatgcat ggacacttac aaacgccttc agagacaaat aggcatagac acacaaccac     2700

tcacagaaac agataccaat atgcatggtc ctgtgtacac agaaacagac tataggcaaa     2760

tatacacaaa taaactatat agatacaaag atatgcatat acacacatgt acagaaacat     2820

cttcacatgt gtacactaac atgtgaacag gtatagcaca cagatacacc tggactctga     2880

ccagggctgt aatctccaag gctcacggct cagagagcct acactaggct gggtcactga     2940

tactcctcag gagcccactc tatgattggg agagataacc ccaggtacaa agtatgccta     3000

tctgtctcaa caccatgggg cagaagatac tccactaacc acccatgaca gaaagttagc     3060

cttggctgtg tctccattaa tagaacacct cagaagacca atgtgaaatt gcctaaccca     3120

ctcacaccca ccctgatctc cagttcaaaa tgcagaaaac ataatgcagt tgtccaaaag     3180

atgccccaac cacacacaca cacacacaca cacacacaca cacacacaca cacacacaca     3240

cacacacaca ccatcaagga gcctctgtaa ggagtcacca cccaataaca ctgcctcttt     3300

gggctcatat cctggacatt cttcatattc atatccattt ggggcctagg ctttagatat     3360

ccccaagggc tcatctttac agggatcaga gatcccaata aatgccctgg tcccacagcc     3420

tccctcaggt atctgtctgt ttatctcttg gtaccaagac ccaacattgc tggcaggggt     3480

aggacaagca acgcacggga actctgatca aagaaagtca tgagatgcct gagtccttca     3540

ggaagtaagg agggacaacc tctggtatcc ctgttcttat tgctaaagcc caagagacag     3600

ggagacctgc tctaaattct cagtctaaac agcaccgatg gcaccacctg ctcagggaaa     3660

gtccagagca caccaatatc attttgccac agttcctgag tctgccttta cccaggtcca     3720

tacattgcat ctgtcttgct tgctctgctg ccccagggct cctggaacaa aggctccaaa     3780

ttagtgtgtc ctacagcttg gcctgttctg tgcctccgtc tagcttgagc tattagggga     3840

ccagtcaata ctcgctaaga ttctccagaa ccatcagggc accccaaccc ttatgcaaat     3900

gctcagtcac cccaagactt ggcttgaccc tccctctctg tgtcccttca tagaggggga     3960

ggtgaatgct gaggaggaag gctttgagaa cctgtggacc actgcctcca ccttcatcgt     4020

cctcttcctc ctgagcctct tctacagcac caccgtcacc ctgttcaagg tagtgtggtt     4080

gtggggctga ggacacaggg ctgggacagg gagtcaccag tcctcactgc ctctacctct     4140

actccctaca agtggacagc aattcacact gtctctgtca cctgcaggtg aaatgactct     4200

cagcatggaa ggacagcaga gaccaagaga tcctcccaca gggacactac ctctgggcct     4260

gggatacctg actgtatgac tagtaaactt attcttacgt ctttcctgtg ttgccctcca     4320

gcttttatct ctgagatggt cttctttcta gactgaccaa agactttttg tcaacttgta     4380

caatctgaag caatgtctgg cccacagaca gctgagctgt aaacaaatgt cacatggaaa     4440

taaatacttt atcttgtgaa ctcactttat tgtgaaggaa tttgttttgt ttttcaaacc     4500

tttcctgcgg tgttgacagc ccaaggatta tctgaataga gcttaggaac tggaaatgga     4560

acagt                                                                 4565


<210>  13
<211>  291
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide

<400>  13
gtgttcatgc ccctagagtt ggctgaaggg ccagatccac ctactctaga ggcatctctc       60

cctgtctgtg aaggcttcca aagtcacgtt cctgtggcta gaaggcagct ccatagccct      120

gctgcagttt cgtcctgtat accaggttca cctactacca tatctagccc tgcctgcctt      180

aagagtagca acaaggaaat agcagggtgt agagggatct cctgtctgac aggaggcaag      240

aagacagatt cttacccctc catttctctt ttatccctct ctggtcctca g               291


<210>  14
<211>  4227
<212>  DNA
<213>  Mus musculus

<400>  14
agagtcagtc cttcccaaat gtcttccccc tcgtctcctg cgagagcccc ctgtctgata       60

agaatctggt ggccatgggc tgcctggccc gggacttcct gcccagcacc atttccttca      120

cctgaaacta ccagaacaac actgaagtca tccagggtat cagaaccttc ccaacactga      180

ggacaggggg caagtaccta gccacctcgc aggtgttgct gtctcccaag agcatccttg      240

aaggttcaga tgaatacctg gtatgcaaaa tccactacgg aggcaaaaac aaagatctgc      300

atgtgcccat tccaggtaag aaccaaaccc tcccagcagg ggtgcccagg cccaggcatg      360

gcccagaggg agcagcgggg tggggcttag gccaagctga gctcacacct tgacctttca      420

ttccagctgt cgcagagatg aaccccaatg taaatgtgtt cgtcccacca cgggatggct      480

tctctggccc tgcaccacgc aagtctaaac tcatctgcga ggccacgaac ttcactccaa      540

aaccgatcac agtatcctga ctaaaggatg ggaagctcgt ggaatctggc ttcaccacag      600

atccggtgac catcgagaac aaaggatcca caccccaaac ctacaaggtc ataagcacac      660

ttaccatctc tgaaatcgac tggctgaacc tgaatgtgta cacctgccgt gtggatcaca      720

ggggtctcac cttcttgaag aacgtgtcct ccacatgtgc tgccagtgag tggcctgggc      780

taagcccaat gcctagccct cccagattag ggaagtcctc ctacaattat ggccaatgcc      840

acccagacat ggtcatttgc tccttgaact ttggctcccc agagtggcca aggacaagaa      900

tgagcaatag gcagtagagg ggtgagaatc agctggaagg accagcatct tcccttaagt      960

aggtttgggg gatggagact aagctttttt ccaacttcac aactagatat gtcataacct     1020

gacacagtgt tctcttgact gcaggtccct ccacagacat cctaaccttc accatccccc     1080

cctcctttgc cgacatcttc ctcagcaagt ccgctaacct gacctgtctg gtctcaaacc     1140

tggcaaccta tgaaaccctg aatatctcct gagcttctca aagtggtgaa ccactggaaa     1200

ccaaaattaa aatcatggaa agccatccca atggcacctt cagtgctaag ggtgtggcta     1260

gtgtttgtgt ggaagactgg aataacagga aggaatttgt gtgtactgtg actcacaggg     1320

atctgccttc accacagaag aaattcatct caaaacccaa tggtaggtat ccccccttcc     1380

cttcccctcc aattgcagga cccttcctgt acctcatagg gagggcaggt cctcttccac     1440

cctatcctca ctactgtctt catttacaga ggtgcacaaa catccacctg ctgtgtacct     1500

gctgccacca gctcgtgagc aactgaacct gagggagtca gccacagtca cctgcctggt     1560

gaagggcttc tctcctgcag acatcagtgt gcagtggctt cagagagggc aactcttgcc     1620

ccaagagaag tatgtgacca gtgccccgat gccagagcct ggggccccag gcttctactt     1680

tacccacagc atcctgactg tgacagagga ggaatggaac tccggagaga cctatacctg     1740

tgttgtaggc cacgaggccc tgccacacct ggtgaccgag aggaccgtgg acaagtccac     1800

tggtaaaccc acactgtaca atgtctccct gatcatgtct gacacaggcg gcacctgcta     1860

ttgaccatgc tagcgctcaa ccaggcaggc cctgggtgtc cagttgctct gtgtatgcaa     1920

actaaccatg tcagagtgag atgttgcatt ttataaaaat tagaaataaa aaaaatccat     1980

tcaaacgtca ctggttttga ttatacaatg ctcatgcctg ctgagacagt tgtgttttgc     2040

ttgctctgca cacaccctgc atacttgcct ccaccctggc ccttcctcta ccttgccagt     2100

ttcctccttg tgtgtgaact cagtcaggct tacaacagac agagtatgaa catgcgattc     2160

ctccagctac ttctagatat atggctgaaa gcttgcctaa cctggtgcag gcagcattca     2220

ggcacatata tagacacaca tgcatttata catagatata taggtacaca tgtgtagaca     2280

catacatgaa tgtgtattca tggacacaca gacaaaggta cacatatata cacatgagtt     2340

catgcgcaca cacatgcatg gacacttaca aacgccttca gagacaaata ggcatagaca     2400

cacaaccact cacagaaaca gataccaata tgcatggtcc tgtgtacaca gaaacagact     2460

ataggcaaat atacacaaat aaactatata gatacaaaga tatgcatata cacacatgta     2520

cagaaacatc ttcacatgtg tacactaaca tgtgaacagg tatagcacac agatacacct     2580

ggactctgac cagggctgta atctccaagg ctcacggctc agagagccta cactaggctg     2640

ggtcactgat actcctcagg agcccactct atgattggga gagataaccc caggtacaaa     2700

gtatgcctat ctgtctcaac accatggggc agaagatact ccactaacca cccatgacag     2760

aaagttagcc ttggctgtgt ctccattaat agaacacctc agaagaccaa tgtgaaattg     2820

cctaacccac tcacacccac cctgatctcc agttcaaaat gcagaaaaca taatgcagtt     2880

gtccaaaaga tgccccaacc acacacacac acacacacac acacacacac acacacacac     2940

acacacacac acacacacac catcaaggag cctctgtaag gagtcaccac ccaataacac     3000

tgcctctttg ggctcatatc ctggacattc ttcatattca tatccatttg gggcctaggc     3060

tttagatatc cccaagggct catctttaca gggatcagag atcccaataa atgccctggt     3120

cccacagcct ccctcaggta tctgtctgtt tatctcttgg taccaagacc caacattgct     3180

ggcaggggta ggacaagcaa cgcacgggaa ctctgatcaa agaaagtcat gagatgcctg     3240

agtccttcag gaagtaagga gggacaacct ctggtatccc tgttcttatt gctaaagccc     3300

aagagacagg gagacctgct ctaaattctc agtctaaaca gcaccgatgg caccacctgc     3360

tcagggaaag tccagagcac accaatatca ttttgccaca gttcctgagt ctgcctttac     3420

ccaggtccat acattgcatc tgtcttgctt gctctgctgc cccagggctc ctggaacaaa     3480

ggctccaaat tagtgtgtcc tacagcttgg cctgttctgt gcctccgtct agcttgagct     3540

attaggggac cagtcaatac tcgctaagat tctccagaac catcagggca ccccaaccct     3600

tatgcaaatg ctcagtcacc ccaagacttg gcttgaccct ccctctctgt gtcccttcat     3660

agagggggag gtgaatgctg aggaggaagg ctttgagaac ctgtggacca ctgcctccac     3720

cttcatcgtc ctcttcctcc tgagcctctt ctacagcacc accgtcaccc tgttcaaggt     3780

agtgtggttg tggggctgag gacacagggc tgggacaggg agtcaccagt cctcactgcc     3840

tctacctcta ctccctacaa gtggacagca attcacactg tctctgtcac ctgcaggtga     3900

aatgactctc agcatggaag gacagcagag accaagagat cctcccacag ggacactacc     3960

tctgggcctg ggatacctga ctgtatgact agtaaactta ttcttacgtc tttcctgtgt     4020

tgccctccag cttttatctc tgagatggtc ttctttctag actgaccaaa gactttttgt     4080

caacttgtac aatctgaagc aatgtctggc ccacagacag ctgagctgta aacaaatgtc     4140

acatggaaat aaatacttta tcttgtgaac tcactttatt gtgaaggaat ttgttttgtt     4200

tttcaaacct ttcctgcggt gttgaca                                         4227


<210>  15
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide

<400>  15
gcccaaggat tatctgaata gagcttagga actggaaatg gaacag                      46


<210>  16
<211>  294
<212>  DNA
<213>  Homo sapiens

<400>  16
cctccaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc acctctgggg       60

gcacagcagc cctgggctgc ctggtcaagg actacttccc cgaaccggtg acggtgtcgt      120

ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta cagtcctcag      180

gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc acccagacct      240

acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa gttg            294


<210>  17
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  17
cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc       60

tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc      120

ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc aagacaaagc      180

cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc      240

aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc ctcccagccc      300

ccatcgagaa aaccatctcc aaagccaaag                                       330


<210>  18
<211>  320
<212>  DNA
<213>  Homo sapiens

<400>  18
ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga       60

accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc gccgtggagt      120

gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg ctggactccg      180

acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg cagcagggga      240

acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacaca cagaagagcc      300

tctccctgtc tccgggtaaa                                                  320


