                               SEQUENCE LISTING

<110> REPAIR BIOTECHNOLOGIES, INC.
 
<120> ENHANCING MITOCHONDRIAL-BASED FLOW AND CATABOLISM OF CHOLESTEROL

<130> P289347.WO.01

<140>
<141>

<150> 63/122,886
<151> 2020-12-08

<160> 12    

<170> PatentIn version 3.5

<210> 1
<211> 1122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Met Leu Ala Lys Gly Leu Pro Pro Arg Ser Val Leu Val Lys Gly Cys 
1               5                   10                  15      


Gln Thr Phe Leu Ser Ala Pro Arg Glu Gly Leu Gly Arg Leu Arg Val 
            20                  25                  30          


Pro Thr Gly Glu Gly Ala Gly Ile Ser Thr Arg Ser Pro Arg Pro Phe 
        35                  40                  45              


Asn Glu Ile Pro Ser Pro Gly Asp Asn Gly Trp Leu Asn Leu Tyr His 
    50                  55                  60                  


Phe Trp Arg Glu Thr Gly Thr His Lys Val His Leu His His Val Gln 
65                  70                  75                  80  


Asn Phe Gln Lys Tyr Gly Pro Ile Tyr Arg Glu Lys Leu Gly Asn Val 
                85                  90                  95      


Glu Ser Val Tyr Val Ile Asp Pro Glu Asp Val Ala Leu Leu Phe Lys 
            100                 105                 110         


Ser Glu Gly Pro Asn Pro Glu Arg Phe Leu Ile Pro Pro Trp Val Ala 
        115                 120                 125             


Tyr His Gln Tyr Tyr Gln Arg Pro Ile Gly Val Leu Leu Lys Lys Ser 
    130                 135                 140                 


Ala Ala Trp Lys Lys Asp Arg Val Ala Leu Asn Gln Glu Val Met Ala 
145                 150                 155                 160 


Pro Glu Ala Thr Lys Asn Phe Leu Pro Leu Leu Asp Ala Val Ser Arg 
                165                 170                 175     


Asp Phe Val Ser Val Leu His Arg Arg Ile Lys Lys Ala Gly Ser Gly 
            180                 185                 190         


Asn Tyr Ser Gly Asp Ile Ser Asp Asp Leu Phe Arg Phe Ala Phe Glu 
        195                 200                 205             


Ser Ile Thr Asn Val Ile Phe Gly Glu Arg Gln Gly Met Leu Glu Glu 
    210                 215                 220                 


Val Val Asn Pro Glu Ala Gln Arg Phe Ile Asp Ala Ile Tyr Gln Met 
225                 230                 235                 240 


Phe His Thr Ser Val Pro Met Leu Asn Leu Pro Pro Asp Leu Phe Arg 
                245                 250                 255     


Leu Phe Arg Thr Lys Thr Trp Lys Asp His Val Ala Ala Trp Asp Val 
            260                 265                 270         


Ile Phe Ser Lys Ala Asp Ile Tyr Thr Gln Asn Phe Tyr Trp Glu Leu 
        275                 280                 285             


Arg Gln Lys Gly Ser Val His His Asp Tyr Arg Gly Ile Leu Tyr Arg 
    290                 295                 300                 


Leu Leu Gly Asp Ser Lys Met Ser Phe Glu Asp Ile Lys Ala Asn Val 
305                 310                 315                 320 


Thr Glu Met Leu Ala Gly Gly Val Asp Thr Thr Ser Met Thr Leu Gln 
                325                 330                 335     


Trp His Leu Tyr Glu Met Ala Arg Asn Leu Lys Val Gln Asp Met Leu 
            340                 345                 350         


Arg Ala Glu Val Leu Ala Ala Arg His Gln Ala Gln Gly Asp Met Ala 
        355                 360                 365             


Thr Met Leu Gln Leu Val Pro Leu Leu Lys Ala Ser Ile Lys Glu Thr 
    370                 375                 380                 


Leu Arg Leu His Pro Ile Ser Val Thr Leu Gln Arg Tyr Leu Val Asn 
385                 390                 395                 400 


Asp Leu Val Leu Arg Asp Tyr Met Ile Pro Ala Lys Thr Leu Val Gln 
                405                 410                 415     


Val Ala Ile Tyr Ala Leu Gly Arg Glu Pro Thr Phe Phe Phe Asp Pro 
            420                 425                 430         


Glu Asn Phe Asp Pro Thr Arg Trp Leu Ser Lys Asp Lys Asn Ile Thr 
        435                 440                 445             


Tyr Phe Arg Asn Leu Gly Phe Gly Trp Gly Val Arg Gln Cys Leu Gly 
    450                 455                 460                 


Arg Arg Ile Ala Glu Leu Glu Met Thr Ile Phe Leu Ile Asn Met Leu 
465                 470                 475                 480 


Glu Asn Phe Arg Val Glu Ile Gln His Leu Ser Asp Val Gly Thr Thr 
                485                 490                 495     


Phe Asn Leu Ile Leu Met Pro Glu Lys Pro Ile Ser Phe Thr Phe Trp 
            500                 505                 510         


Pro Phe Asn Gln Glu Ala Thr Gln Gln Thr Asp Gly Thr Ser Ser Thr 
        515                 520                 525             


Gln Glu Lys Thr Pro Gln Ile Cys Val Val Gly Ser Gly Pro Ala Gly 
    530                 535                 540                 


Phe Tyr Thr Ala Gln His Leu Leu Lys His Pro Gln Ala His Val Asp 
545                 550                 555                 560 


Ile Tyr Glu Lys Gln Pro Val Pro Phe Gly Leu Val Arg Phe Gly Val 
                565                 570                 575     


Ala Pro Asp His Pro Glu Val Lys Asn Val Ile Asn Thr Phe Thr Gln 
            580                 585                 590         


Thr Ala His Ser Gly Arg Cys Ala Phe Trp Gly Asn Val Glu Val Gly 
        595                 600                 605             


Arg Asp Val Thr Val Pro Glu Leu Arg Glu Ala Tyr His Ala Val Val 
    610                 615                 620                 


Leu Ser Tyr Gly Ala Glu Asp His Arg Ala Leu Glu Ile Pro Gly Glu 
625                 630                 635                 640 


Glu Leu Pro Gly Val Cys Ser Ala Arg Ala Phe Val Gly Trp Tyr Asn 
                645                 650                 655     


Gly Leu Pro Glu Asn Gln Glu Leu Glu Pro Asp Leu Ser Cys Asp Thr 
            660                 665                 670         


Ala Val Ile Leu Gly Gln Gly Asn Val Ala Leu Asp Val Ala Arg Ile 
        675                 680                 685             


Leu Leu Thr Pro Pro Glu His Leu Glu Arg Thr Asp Ile Thr Lys Ala 
    690                 695                 700                 


Ala Leu Gly Val Leu Arg Gln Ser Arg Val Lys Thr Val Trp Leu Val 
705                 710                 715                 720 


Gly Arg Arg Gly Pro Leu Gln Val Ala Phe Thr Ile Lys Glu Leu Arg 
                725                 730                 735     


Glu Met Ile Gln Leu Pro Gly Ala Arg Pro Ile Leu Asp Pro Val Asp 
            740                 745                 750         


Phe Leu Gly Leu Gln Asp Lys Ile Lys Glu Val Pro Arg Pro Arg Lys 
        755                 760                 765             


Arg Leu Thr Glu Leu Leu Leu Arg Thr Ala Thr Glu Lys Pro Gly Pro 
    770                 775                 780                 


Ala Glu Ala Ala Arg Gln Ala Ser Ala Ser Arg Ala Trp Gly Leu Arg 
785                 790                 795                 800 


Phe Phe Arg Ser Pro Gln Gln Val Leu Pro Ser Pro Asp Gly Arg Arg 
                805                 810                 815     


Ala Ala Gly Val Arg Leu Ala Val Thr Arg Leu Glu Gly Val Asp Glu 
            820                 825                 830         


Ala Thr Arg Ala Val Pro Thr Gly Asp Met Glu Asp Leu Pro Cys Gly 
        835                 840                 845             


Leu Val Leu Ser Ser Ile Gly Tyr Lys Ser Arg Pro Val Asp Pro Ser 
    850                 855                 860                 


Val Pro Phe Asp Ser Lys Leu Gly Val Ile Pro Asn Val Glu Gly Arg 
865                 870                 875                 880 


Val Met Asp Val Pro Gly Leu Tyr Cys Ser Gly Trp Val Lys Arg Gly 
                885                 890                 895     


Pro Thr Gly Val Ile Ala Thr Thr Met Thr Asp Ser Phe Leu Thr Gly 
            900                 905                 910         


Gln Met Leu Leu Gln Asp Leu Lys Ala Gly Leu Leu Pro Ser Gly Pro 
        915                 920                 925             


Arg Pro Gly Tyr Ala Ala Ile Gln Ala Leu Leu Ser Ser Arg Gly Val 
    930                 935                 940                 


Arg Pro Val Ser Phe Ser Asp Trp Glu Lys Leu Asp Ala Glu Glu Val 
945                 950                 955                 960 


Ala Arg Gly Gln Gly Thr Gly Lys Pro Arg Glu Lys Leu Val Asp Pro 
                965                 970                 975     


Gln Glu Met Leu Arg Leu Leu Gly His Thr Asp Gly Ala Ser Ser Ser 
            980                 985                 990         


Ser Glu Asp Lys Ile Thr Val His  Phe Ile Asn Arg Asp  Gly Glu Thr 
        995                 1000                 1005             


Leu Thr  Thr Lys Gly Lys Val  Gly Asp Ser Leu Leu  Asp Val Val 
    1010                 1015                 1020             


Val Glu  Asn Asn Leu Asp Ile  Asp Gly Phe Gly Ala  Cys Glu Gly 
    1025                 1030                 1035             


Thr Leu  Ala Cys Ser Thr Cys  His Leu Ile Phe Glu  Asp His Ile 
    1040                 1045                 1050             


Tyr Glu  Lys Leu Asp Ala Ile  Thr Asp Glu Glu Asn  Asp Met Leu 
    1055                 1060                 1065             


Asp Leu  Ala Tyr Gly Leu Thr  Asp Arg Ser Arg Leu  Gly Cys Gln 
    1070                 1075                 1080             


Ile Cys  Leu Thr Lys Ser Met  Asp Asn Met Thr Val  Arg Val Pro 
    1085                 1090                 1095             


Glu Thr  Val Ala Asp Ala Arg  Gln Ser Ile Asp Val  Gly Lys Thr 
    1100                 1105                 1110             


Ser Asp  Tyr Lys Asp Asp Asp  Asp Lys 
    1115                 1120         


<210> 2
<211> 427
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Cholesterol dehydrogenase sequence

<400> 2
Met Pro Thr Leu Tyr Lys Lys Ala Gly Phe Gln Leu Gly Ser Leu Glu 
1               5                   10                  15      


Asn Leu Tyr Phe Gln Gly His His His His His His Gly Thr Met Ala 
            20                  25                  30          


Gly Phe Leu Asn Cys Cys Pro Gly Cys Cys Met Glu Pro Gly Ala Ser 
        35                  40                  45              


Asp Tyr Lys Asp Asp Asp Asp Lys Met Leu Arg Arg Met Gly Asp Ala 
    50                  55                  60                  


Ser Leu Thr Thr Glu Leu Gly Arg Val Leu Val Thr Gly Gly Ala Gly 
65                  70                  75                  80  


Phe Val Gly Ala Asn Leu Val Thr Thr Leu Leu Asp Arg Gly His Trp 
                85                  90                  95      


Val Arg Ser Phe Asp Arg Ala Pro Ser Leu Leu Pro Ala His Pro Gln 
            100                 105                 110         


Leu Glu Val Leu Gln Gly Asp Ile Thr Asp Ala Asp Val Cys Ala Ala 
        115                 120                 125             


Ala Val Asp Gly Ile Asp Thr Ile Phe His Thr Ala Ala Ile Ile Glu 
    130                 135                 140                 


Leu Met Gly Gly Ala Ser Val Thr Asp Glu Tyr Arg Gln Arg Ser Phe 
145                 150                 155                 160 


Ala Val Asn Val Gly Gly Thr Glu Asn Leu Leu His Ala Gly Gln Arg 
                165                 170                 175     


Ala Gly Val Gln Arg Phe Val Tyr Thr Ser Ser Asn Ser Val Val Met 
            180                 185                 190         


Gly Gly Gln Asn Ile Ala Gly Gly Asp Glu Thr Leu Pro Tyr Thr Asp 
        195                 200                 205             


Arg Phe Asn Asp Leu Tyr Thr Glu Thr Lys Val Val Ala Glu Arg Phe 
    210                 215                 220                 


Val Leu Ala Gln Asn Gly Val Asp Gly Met Leu Thr Cys Ala Ile Arg 
225                 230                 235                 240 


Pro Ser Gly Ile Trp Gly Asn Gly Asp Gln Thr Met Phe Arg Lys Leu 
                245                 250                 255     


Phe Glu Ser Val Leu Lys Gly His Val Lys Val Leu Val Gly Arg Lys 
            260                 265                 270         


Ser Ala Arg Leu Asp Asn Ser Tyr Val His Asn Leu Ile His Gly Phe 
        275                 280                 285             


Ile Leu Ala Ala Ala His Leu Val Pro Asp Gly Thr Ala Pro Gly Gln 
    290                 295                 300                 


Ala Tyr Phe Ile Asn Asp Ala Glu Pro Ile Asn Met Phe Glu Phe Ala 
305                 310                 315                 320 


Arg Pro Val Leu Glu Ala Cys Gly Gln Arg Trp Pro Lys Met Arg Ile 
                325                 330                 335     


Ser Gly Pro Ala Val Arg Trp Val Met Thr Gly Trp Gln Arg Leu His 
            340                 345                 350         


Phe Arg Phe Gly Phe Pro Ala Pro Leu Leu Glu Pro Leu Ala Val Glu 
        355                 360                 365             


Arg Leu Tyr Leu Asp Asn Tyr Phe Ser Ile Ala Lys Ala Arg Arg Asp 
    370                 375                 380                 


Leu Gly Tyr Glu Pro Leu Phe Thr Thr Gln Gln Ala Leu Thr Glu Cys 
385                 390                 395                 400 


Leu Pro Tyr Tyr Val Ser Leu Phe Glu Gln Met Lys Asn Glu Ala Arg 
                405                 410                 415     


Ala Glu Lys Thr Ala Ala Thr Val Lys Pro Gly 
            420                 425         


<210> 3
<211> 510
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      3-ketosteroid delta1-dehydrogenase sequence

<400> 3
Met Gln Asp Trp Thr Ser Glu Cys Asp Val Leu Val Val Gly Ser Gly 
1               5                   10                  15      


Gly Gly Ala Leu Thr Gly Ala Tyr Thr Ala Ala Ala Gln Gly Leu Thr 
            20                  25                  30          


Thr Ile Val Leu Glu Lys Thr Asp Arg Phe Gly Gly Thr Ser Ala Tyr 
        35                  40                  45              


Ser Gly Ala Ser Ile Trp Leu Pro Gly Thr Gln Val Gln Glu Arg Ala 
    50                  55                  60                  


Gly Leu Pro Asp Ser Thr Glu Asn Ala Arg Thr Tyr Leu Arg Ala Leu 
65                  70                  75                  80  


Leu Gly Asp Ala Glu Ser Glu Arg Gln Asp Ala Tyr Val Glu Thr Ala 
                85                  90                  95      


Pro Ala Val Val Ala Leu Leu Glu Gln Asn Pro Asn Ile Glu Phe Glu 
            100                 105                 110         


Phe Arg Ala Phe Pro Asp Tyr Tyr Lys Ala Glu Gly Arg Met Asp Thr 
        115                 120                 125             


Gly Arg Ser Ile Asn Pro Leu Asp Leu Asp Pro Ala Asp Ile Gly Asp 
    130                 135                 140                 


Leu Ala Gly Lys Val Arg Pro Glu Leu Asp Gln Asp Arg Thr Gly Gln 
145                 150                 155                 160 


Asp His Ala Pro Gly Pro Met Ile Gly Gly Arg Ala Leu Ile Gly Arg 
                165                 170                 175     


Leu Leu Ala Ala Val Gln Ser Thr Gly Lys Ala Glu Leu Arg Thr Glu 
            180                 185                 190         


Ser Val Leu Thr Ser Leu Ile Val Glu Asp Gly Arg Val Val Gly Ala 
        195                 200                 205             


Glu Val Glu Ser Gly Gly Glu Thr Gln Arg Ile Lys Ala Asn Arg Gly 
    210                 215                 220                 


Val Leu Met Ala Ala Gly Gly Ile Glu Gly Asn Ala Glu Met Arg Glu 
225                 230                 235                 240 


Gln Ala Gly Thr Pro Gly Lys Ala Ile Trp Ser Met Gly Pro Phe Gly 
                245                 250                 255     


Ala Asn Thr Gly Asp Ala Ile Ser Ala Gly Ile Ala Val Gly Gly Ala 
            260                 265                 270         


Thr Ala Leu Leu Asp Gln Ala Trp Phe Cys Pro Gly Val Glu Gln Pro 
        275                 280                 285             


Asp Gly Ser Ala Ala Phe Met Val Gly Val Arg Gly Gly Leu Val Val 
    290                 295                 300                 


Asp Ser Ala Gly Glu Arg Tyr Leu Asn Glu Ser Leu Pro Tyr Asp Gln 
305                 310                 315                 320 


Phe Gly Arg Ala Met Asp Ala His Asp Asp Asn Gly Ser Ala Val Pro 
                325                 330                 335     


Ser Phe Met Ile Phe Asp Ser Arg Glu Gly Gly Gly Leu Pro Ala Ile 
            340                 345                 350         


Cys Ile Pro Asn Thr Ala Pro Ala Lys His Leu Glu Ala Gly Thr Trp 
        355                 360                 365             


Val Gly Ala Asp Thr Leu Glu Glu Leu Ala Ala Lys Thr Gly Leu Pro 
    370                 375                 380                 


Ala Asp Ala Leu Arg Ser Thr Val Glu Lys Phe Asn Asp Ala Ala Lys 
385                 390                 395                 400 


Leu Gly Val Asp Glu Glu Phe His Arg Gly Glu Asp Pro Tyr Asp Ala 
                405                 410                 415     


Phe Phe Cys Pro Pro Asn Gly Gly Ala Asn Ala Ala Leu Thr Ala Ile 
            420                 425                 430         


Glu Asn Gly Pro Phe Tyr Ala Ala Arg Ile Val Leu Ser Asp Leu Gly 
        435                 440                 445             


Thr Lys Gly Gly Leu Val Thr Asp Val Asn Gly Arg Val Leu Arg Ala 
    450                 455                 460                 


Asp Gly Ser Ala Ile Asp Gly Leu Tyr Ala Ala Gly Asn Thr Ser Ala 
465                 470                 475                 480 


Ser Leu Ser Gly Arg Phe Tyr Pro Gly Pro Gly Val Pro Leu Gly Thr 
                485                 490                 495     


Ala Met Val Phe Ser Tyr Arg Ala Ala Gln Asp Met Ala Lys 
            500                 505                 510 


<210> 4
<211> 595
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Anoxic cholesterol metabolism beta enzyme sequence

<400> 4
Met Pro Thr Leu Tyr Lys Lys Ala Gly Phe Gln Leu Gly Ser Gly Thr 
1               5                   10                  15      


Glu Asn Leu Tyr Phe Gln Gly Thr Met Ser Ile Glu Thr Asn Thr Tyr 
            20                  25                  30          


Asp Val Ile Val Val Gly Ser Gly Ala Gly Ala Met Leu Ala Ala Ala 
        35                  40                  45              


Arg Ala His Asp Leu Gly Leu Ser Val Leu Val Val Glu Lys Ser Asp 
    50                  55                  60                  


Lys Tyr Gly Gly Thr Ser Ala Val Ser Gly Gly Ala Val Trp Ile Pro 
65                  70                  75                  80  


Asn Asn Ser Gln Met Gln Ile Lys Asp Ser Phe Asp Glu Ala Leu Thr 
                85                  90                  95      


Tyr Leu Lys Ala Ala Thr Gln Gly Leu Val Ala Glu Asp Arg Leu Leu 
            100                 105                 110         


Ala Tyr Leu Glu Ser Ala Pro Gln Met Val Glu Tyr Ile Asn Ala Asn 
        115                 120                 125             


Met Thr Leu Gln Tyr Phe Pro Cys His Arg Tyr Pro Asp Tyr Tyr Gln 
    130                 135                 140                 


His Leu Pro Gly Ala Lys Pro Gly Gly Arg Thr Met Glu Pro Met Leu 
145                 150                 155                 160 


Phe Asp Ala Ala Leu Leu Gly Asp Glu Phe Ala Asn Leu Arg Met Ala 
                165                 170                 175     


Tyr Thr Gly Thr Leu Leu Met Gly Lys Ala Ser Met Thr Ala Thr Glu 
            180                 185                 190         


Ala His Val Met Leu Ala Lys Glu Pro Gly Trp Met Leu Gln Val Ile 
        195                 200                 205             


Lys Ser Leu Gly Arg Tyr Tyr Leu Asp Leu Pro Trp Arg Leu Lys Ser 
    210                 215                 220                 


Arg His Asp Arg Lys Arg Gly Leu Gly Asn Ala Met Ala Ala Gly Leu 
225                 230                 235                 240 


Arg His Ala Leu Leu Glu Arg Lys Val Pro Leu Trp Leu Asn Thr Pro 
                245                 250                 255     


Phe Glu Ser Leu Ile Thr Glu Gly Ala Glu Asn Lys Arg Val Thr Gly 
            260                 265                 270         


Ile Val Val Lys Arg Asn Gly Gln Thr Leu Gln Leu Thr Ala Arg Arg 
        275                 280                 285             


Gly Val Val Leu Gly Ala Gly Gly Phe Glu Arg Asn Gln Gln Met Arg 
    290                 295                 300                 


Glu Gln Tyr Leu Pro Lys Pro Thr Asn Ala Ala Trp Ser Ala Thr Pro 
305                 310                 315                 320 


Pro His Asn Thr Gly Asp Thr Ile Arg Ala Ala Met Asp Ile Gly Ala 
                325                 330                 335     


Arg Ala Glu Leu Met Asp Trp Ala Trp Trp Val Pro Ser Ile His Val 
            340                 345                 350         


Pro Gly Glu Ala Ala Gln Thr Gly Leu Phe Ala Glu Arg Asn Leu Pro 
        355                 360                 365             


Gly Cys Ile Val Val Asn Gly Lys Gly Gln Arg Phe Ile Asn Glu Ala 
    370                 375                 380                 


Ser Pro Tyr Leu Glu Phe Gly Ala Ala Met Tyr Glu Asn His Ala Arg 
385                 390                 395                 400 


Ser Gly Ser Ala Val Pro Ala Trp Leu Ile Phe Asp Gly Lys Phe Arg 
                405                 410                 415     


Tyr Asn Tyr Pro Met Gly Pro Leu Met Pro Gly Gln Ile Gln Pro Asp 
            420                 425                 430         


Arg Lys Ala Trp Leu Gly Lys Val Tyr Trp Arg Asp Asp Thr Leu Glu 
        435                 440                 445             


Gly Leu Ala Lys Gln Ile Gly Val Asp Ala Ala Gly Leu Lys Gln Ser 
    450                 455                 460                 


Val Glu Leu Asn Asn Gln Tyr Ala Gln Asp Gly Lys Asp Arg Glu Phe 
465                 470                 475                 480 


Asp Lys Gly Gly Asn Val Phe Asp Arg Tyr Tyr Gly Asp Tyr Asn Val 
                485                 490                 495     


Lys Pro Asn Pro Cys Leu Ala Pro Ile Gly Lys Pro Pro Tyr Tyr Ala 
            500                 505                 510         


Met Arg Val Asp Ala Gly Asp Ile Gly Thr Lys Gly Gly Leu Leu Thr 
        515                 520                 525             


Asp Lys Asp Ala Arg Val Leu Asp Glu Ser Asp Arg Pro Ile Glu Gly 
    530                 535                 540                 


Leu Tyr Cys Ile Gly Asn Asn Ser Ala Ser Val Met Gly Lys Ala Tyr 
545                 550                 555                 560 


Pro Gly Ala Gly Gly Thr Leu Gly Pro Ala Met Thr Phe Gly Phe Arg 
                565                 570                 575     


Ala Ala Asn His Ile Ala Ala Ser Lys Tyr Pro Tyr Asp Val Pro Asp 
            580                 585                 590         


Tyr Ala Gly 
        595 


<210> 5
<211> 860
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      3-ketosteroid 9alpha-hydroxylase sequence

<400> 5
Met Ala Pro Tyr Ser Leu Leu Val Thr Arg Leu Gln Lys Ala Leu Gly 
1               5                   10                  15      


Val Arg Gln Tyr His Val Ala Ser Val Leu Cys Gln Arg Ala Lys Val 
            20                  25                  30          


Ala Met Ser Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly Gly Ser 
        35                  40                  45              


Met Ser Ile Asp Thr Ala Arg Ser Gly Ser Asp Asp Asp Val Glu Ile 
    50                  55                  60                  


Arg Glu Ile Gln Ala Ala Ala Ala Pro Thr Arg Phe Ala Arg Gly Trp 
65                  70                  75                  80  


His Cys Leu Gly Leu Leu Arg Asp Phe Gln Asp Gly Lys Pro His Ser 
                85                  90                  95      


Ile Glu Ala Phe Gly Thr Lys Leu Val Val Phe Ala Asp Ser Lys Gly 
            100                 105                 110         


Gln Leu Asn Val Leu Asp Ala Tyr Cys Arg His Met Gly Gly Asp Leu 
        115                 120                 125             


Ser Arg Gly Glu Val Lys Gly Asp Ser Ile Ala Cys Pro Phe His Asp 
    130                 135                 140                 


Trp Arg Trp Asn Gly Lys Gly Lys Cys Thr Asp Ile Pro Tyr Ala Arg 
145                 150                 155                 160 


Arg Val Pro Pro Ile Ala Lys Thr Arg Ala Trp Thr Thr Leu Glu Arg 
                165                 170                 175     


Asn Gly Gln Leu Tyr Val Trp Asn Asp Pro Gln Gly Asn Pro Pro Pro 
            180                 185                 190         


Glu Asp Val Thr Ile Pro Glu Ile Ala Gly Tyr Gly Thr Asp Glu Trp 
        195                 200                 205             


Thr Asp Trp Ser Trp Lys Ser Leu Arg Ile Lys Gly Ser His Cys Arg 
    210                 215                 220                 


Glu Ile Val Asp Asn Val Val Asp Met Ala His Phe Phe Tyr Ile His 
225                 230                 235                 240 


Tyr Ser Phe Pro Arg Tyr Phe Lys Asn Val Phe Glu Gly His Thr Ala 
                245                 250                 255     


Thr Gln Tyr Met His Ser Thr Gly Arg Glu Asp Val Ile Ser Gly Thr 
            260                 265                 270         


Asn Tyr Asp Asp Pro Asn Ala Glu Leu Arg Ser Glu Ala Thr Tyr Phe 
        275                 280                 285             


Gly Pro Ser Tyr Met Ile Asp Trp Leu Glu Ser Asp Ala Asn Gly Gln 
    290                 295                 300                 


Thr Ile Glu Thr Ile Leu Ile Asn Cys His Tyr Pro Val Ser Asn Asn 
305                 310                 315                 320 


Glu Phe Val Leu Gln Tyr Gly Ala Ile Val Lys Lys Leu Pro Gly Val 
                325                 330                 335     


Ser Asp Glu Ile Ala Ala Gly Met Ala Glu Gln Phe Ala Glu Gly Val 
            340                 345                 350         


Gln Leu Gly Phe Glu Gln Asp Val Glu Ile Trp Lys Asn Lys Ala Pro 
        355                 360                 365             


Ile Asp Asn Pro Leu Leu Ser Glu Glu Asp Gly Pro Val Tyr Gln Leu 
    370                 375                 380                 


Arg Arg Trp Tyr Gln Gln Phe Tyr Val Asp Val Glu Asp Ile Thr Glu 
385                 390                 395                 400 


Asp Met Thr Lys Arg Phe Glu Phe Glu Ile Asp Thr Thr Arg Ala Val 
                405                 410                 415     


Ala Ser Trp Gln Lys Glu Val Ala Glu Asn Leu Ala Lys Gln Ala Glu 
            420                 425                 430         


Gly Ser Thr Ala Thr Pro Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
        435                 440                 445             


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Pro Tyr 
    450                 455                 460                 


Ser Leu Leu Val Thr Arg Leu Gln Lys Ala Leu Gly Val Arg Gln Tyr 
465                 470                 475                 480 


His Val Ala Ser Val Leu Cys Gln Arg Ala Lys Val Ala Met Ser Gly 
                485                 490                 495     


Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly Gly Gly Gly Ser Met Thr 
            500                 505                 510         


Ala Val Gln Ala Pro Val Thr Ser Arg Ala Thr Val Leu Thr Val Ser 
        515                 520                 525             


Ala Val Val Gln Glu Thr Ala Asp Ala Val Ser Leu Val Phe Asp Val 
    530                 535                 540                 


Pro Asp Asp Arg Arg Glu Asp Phe Thr Tyr Arg Pro Gly Gln Phe Leu 
545                 550                 555                 560 


Thr Leu Arg Ile Pro Ser Asp Arg Thr Gly Ser Val Ala Arg Cys Tyr 
                565                 570                 575     


Ser Leu Ala Ser Ser Pro Phe Thr Gly Glu Pro Pro Lys Val Thr Val 
            580                 585                 590         


Lys Arg Thr Ala Gly Gly Tyr Gly Ser Asn Trp Leu Cys Asp Asn Ile 
        595                 600                 605             


Val Ala Gly Arg Ser Ile Glu Val Leu Pro Pro Ala Gly Val Phe Thr 
    610                 615                 620                 


Pro Ala Asp Leu Thr Glu Lys Leu Val Leu Phe Ala Gly Gly Ser Gly 
625                 630                 635                 640 


Ile Thr Pro Val Met Ser Ile Leu Glu Ser Ala Leu His Ser Gly Asn 
                645                 650                 655     


Arg Asp Val Val Leu Ile Tyr Gly Asn Arg Asp Glu Lys Ser Val Ile 
            660                 665                 670         


Phe Ala Glu Lys Leu Arg Glu Leu Ala Ala Arg His Ala Gly Ala Leu 
        675                 680                 685             


Thr Val Val His Trp Leu Glu Ser Val Gln Gly Leu Pro Ser Pro Gln 
    690                 695                 700                 


Gln Leu Ala Thr Leu Ile Ser Pro Phe Ala Asp His Arg Ala Tyr Met 
705                 710                 715                 720 


Cys Gly Pro Gly Pro Phe Met Asp Thr Val Arg Glu Gly Leu Leu Leu 
                725                 730                 735     


Ala Gly Val Pro Lys Asp Arg Ile His Ala Glu Val Phe Thr Ser Leu 
            740                 745                 750         


Ser Gly Asp Pro Phe Ala Asp Val Pro Leu Val Glu Ile Asp Glu Ser 
        755                 760                 765             


Asp Ala Asp Ala Thr Ser Ala Thr Val Gln Leu Asp Gly Glu Glu His 
    770                 775                 780                 


Asp Leu Val Trp Pro Arg Ser Ala Thr Leu Val Asp Val Met Leu Ser 
785                 790                 795                 800 


Lys Gly Leu Asp Val Pro Tyr Ser Cys Arg Glu Gly Glu Cys Gly Ser 
                805                 810                 815     


Cys Ala Cys Thr Val Val Glu Gly Asp Val Asp Ser Leu Pro Ser Ala 
            820                 825                 830         


Ile Leu Asp Glu Glu Asp Ile Ala Asn Gly Tyr Val Leu Ala Cys Gln 
        835                 840                 845             


Ala Arg Pro Lys Ser Asp His Val Arg Ile Glu Phe 
    850                 855                 860 


<210> 6
<211> 372
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      3beta-hydroxysteroid dehydrogenase sequence

<400> 6
Met Gly Trp Ser Cys Leu Val Thr Gly Ala Gly Gly Leu Leu Gly Gln 
1               5                   10                  15      


Arg Ile Val Arg Leu Leu Val Glu Glu Lys Glu Leu Lys Glu Ile Arg 
            20                  25                  30          


Ala Leu Asp Lys Ala Phe Arg Pro Glu Leu Arg Glu Glu Phe Ser Lys 
        35                  40                  45              


Leu Gln Asn Arg Thr Lys Leu Thr Val Leu Glu Gly Asp Ile Leu Asp 
    50                  55                  60                  


Glu Pro Phe Leu Lys Arg Ala Cys Gln Asp Val Ser Val Val Ile His 
65                  70                  75                  80  


Thr Ala Cys Ile Ile Asp Val Phe Gly Val Thr His Arg Glu Ser Ile 
                85                  90                  95      


Met Asn Val Asn Val Lys Gly Thr Gln Leu Leu Leu Glu Ala Cys Val 
            100                 105                 110         


Gln Ala Ser Val Pro Val Phe Ile Tyr Thr Ser Ser Ile Glu Val Ala 
        115                 120                 125             


Gly Pro Asn Ser Tyr Lys Glu Ile Ile Gln Asn Gly His Glu Glu Glu 
    130                 135                 140                 


Pro Leu Glu Asn Thr Trp Pro Thr Pro Tyr Pro Tyr Ser Lys Lys Leu 
145                 150                 155                 160 


Ala Glu Lys Ala Val Leu Ala Ala Asn Gly Trp Asn Leu Lys Asn Gly 
                165                 170                 175     


Asp Thr Leu Tyr Thr Cys Ala Leu Arg Pro Thr Tyr Ile Tyr Gly Glu 
            180                 185                 190         


Gly Gly Pro Phe Leu Ser Ala Ser Ile Asn Glu Ala Leu Asn Asn Asn 
        195                 200                 205             


Gly Ile Leu Ser Ser Val Gly Lys Phe Ser Thr Val Asn Pro Val Tyr 
    210                 215                 220                 


Val Gly Asn Val Ala Trp Ala His Ile Leu Ala Leu Arg Ala Leu Arg 
225                 230                 235                 240 


Asp Pro Lys Lys Ala Pro Ser Val Arg Gly Gln Phe Tyr Tyr Ile Ser 
                245                 250                 255     


Asp Asp Thr Pro His Gln Ser Tyr Asp Asn Leu Asn Tyr Ile Leu Ser 
            260                 265                 270         


Lys Glu Phe Gly Leu Arg Leu Asp Ser Arg Trp Ser Leu Pro Leu Thr 
        275                 280                 285             


Leu Met Tyr Trp Ile Gly Phe Leu Leu Glu Val Val Ser Phe Leu Leu 
    290                 295                 300                 


Ser Pro Ile Tyr Ser Tyr Gln Pro Pro Phe Asn Arg His Thr Val Thr 
305                 310                 315                 320 


Leu Ser Asn Ser Val Phe Thr Phe Ser Tyr Lys Lys Ala Gln Arg Asp 
                325                 330                 335     


Leu Ala Tyr Lys Pro Leu Tyr Ser Trp Glu Glu Ala Lys Gln Lys Thr 
            340                 345                 350         


Val Glu Trp Val Gly Ser Leu Val Asp Arg His Lys Glu Thr Leu Lys 
        355                 360                 365             


Ser Lys Thr Gln 
    370         


<210> 7
<211> 285
<212> PRT
<213> Homo sapiens

<400> 7
Met Leu Leu Ala Thr Phe Lys Leu Cys Ala Gly Ser Ser Tyr Arg His 
1               5                   10                  15      


Met Arg Asn Met Lys Gly Leu Arg Gln Gln Ala Val Met Ala Ile Ser 
            20                  25                  30          


Gln Glu Leu Asn Arg Arg Ala Leu Gly Gly Pro Thr Pro Ser Thr Trp 
        35                  40                  45              


Ile Asn Gln Val Arg Arg Arg Ser Ser Leu Leu Gly Ser Arg Leu Glu 
    50                  55                  60                  


Glu Thr Leu Tyr Ser Asp Gln Glu Leu Ala Tyr Leu Gln Gln Gly Glu 
65                  70                  75                  80  


Glu Ala Met Gln Lys Ala Leu Gly Ile Leu Ser Asn Gln Glu Gly Trp 
                85                  90                  95      


Lys Lys Glu Ser Gln Gln Asp Asn Gly Asp Lys Val Met Ser Lys Val 
            100                 105                 110         


Val Pro Asp Val Gly Lys Val Phe Arg Leu Glu Val Val Val Asp Gln 
        115                 120                 125             


Pro Met Glu Arg Leu Tyr Glu Glu Leu Val Glu Arg Met Glu Ala Met 
    130                 135                 140                 


Gly Glu Trp Asn Pro Asn Val Lys Glu Ile Lys Val Leu Gln Lys Ile 
145                 150                 155                 160 


Gly Lys Asp Thr Phe Ile Thr His Glu Leu Ala Ala Glu Ala Ala Gly 
                165                 170                 175     


Asn Leu Val Gly Pro Arg Asp Phe Val Ser Val Arg Cys Ala Lys Arg 
            180                 185                 190         


Arg Gly Ser Thr Cys Val Leu Ala Gly Met Ala Thr Asp Phe Gly Asn 
        195                 200                 205             


Met Pro Glu Gln Lys Gly Val Ile Arg Ala Glu His Gly Pro Thr Cys 
    210                 215                 220                 


Met Val Leu His Pro Leu Ala Gly Ser Pro Ser Lys Thr Lys Leu Thr 
225                 230                 235                 240 


Trp Leu Leu Ser Ile Asp Leu Lys Gly Trp Leu Pro Lys Ser Ile Ile 
                245                 250                 255     


Asn Gln Val Leu Ser Gln Thr Gln Val Asp Phe Ala Asn His Leu Arg 
            260                 265                 270         


Lys Arg Leu Glu Ser His Pro Ala Ser Glu Ala Arg Cys 
        275                 280                 285 


<210> 8
<211> 145
<212> PRT
<213> Homo sapiens

<400> 8
Met Val Gly Arg Asn Ser Ala Ile Ala Ala Gly Val Cys Gly Ala Leu 
1               5                   10                  15      


Phe Ile Gly Tyr Cys Ile Tyr Phe Asp Arg Lys Arg Arg Ser Asp Pro 
            20                  25                  30          


Asn Phe Lys Asn Arg Leu Arg Glu Arg Arg Lys Lys Gln Lys Leu Ala 
        35                  40                  45              


Lys Glu Arg Ala Gly Leu Ser Lys Leu Pro Asp Leu Lys Asp Ala Glu 
    50                  55                  60                  


Ala Val Gln Lys Phe Phe Leu Glu Glu Ile Gln Leu Gly Glu Glu Leu 
65                  70                  75                  80  


Leu Ala Gln Gly Glu Tyr Glu Lys Gly Val Asp His Leu Thr Asn Ala 
                85                  90                  95      


Ile Ala Val Cys Gly Gln Pro Gln Gln Leu Leu Gln Val Leu Gln Gln 
            100                 105                 110         


Thr Leu Pro Pro Pro Val Phe Gln Met Leu Leu Thr Lys Leu Pro Thr 
        115                 120                 125             


Ile Ser Gln Arg Ile Val Ser Ala Gln Ser Leu Ala Glu Asp Asp Val 
    130                 135                 140                 


Glu 
145 


<210> 9
<211> 375
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Met Val Gly Arg Asn Ser Ala Ile Ala Ala Gly Val Cys Gly Ala Leu 
1               5                   10                  15      


Phe Ile Gly Tyr Cys Ile Tyr Phe Asp Arg Lys Arg Arg Ser Asp Pro 
            20                  25                  30          


Asn Phe Lys Asn Arg Leu Arg Glu Arg Arg Lys Lys Gln Lys Leu Ala 
        35                  40                  45              


Lys Glu Arg Ala Gly Leu Ser Lys Leu Pro Asp Leu Lys Asp Ala Glu 
    50                  55                  60                  


Ala Val Gln Lys Phe Phe Leu Glu Glu Ile Gln Leu Gly Glu Glu Leu 
65                  70                  75                  80  


Leu Ala Gln Gly Glu Tyr Glu Lys Gly Val Asp His Leu Thr Asn Ala 
                85                  90                  95      


Ile Ala Val Cys Gly Gln Pro Gln Gln Leu Leu Gln Val Leu Gln Gln 
            100                 105                 110         


Thr Leu Pro Pro Pro Val Phe Gln Met Leu Leu Thr Lys Leu Pro Thr 
        115                 120                 125             


Ile Ser Gln Arg Ile Val Ser Ala Gln Ser Leu Ala Glu Asp Asp Val 
    130                 135                 140                 


Glu Gly Ser Asp Asp Asp Asp Lys Leu Glu Glu Thr Leu Tyr Ser Asp 
145                 150                 155                 160 


Gln Glu Leu Ala Tyr Leu Gln Gln Gly Glu Glu Ala Met Gln Lys Ala 
                165                 170                 175     


Leu Gly Ile Leu Ser Asn Gln Glu Gly Trp Lys Lys Glu Ser Gln Gln 
            180                 185                 190         


Asp Asn Gly Asp Lys Val Met Ser Lys Val Val Pro Asp Val Gly Lys 
        195                 200                 205             


Val Phe Arg Leu Glu Val Val Val Asp Gln Pro Met Glu Arg Leu Tyr 
    210                 215                 220                 


Glu Glu Leu Val Glu Arg Met Glu Ala Met Gly Glu Trp Asn Pro Asn 
225                 230                 235                 240 


Val Lys Glu Ile Lys Val Leu Gln Lys Ile Gly Lys Asp Thr Phe Ile 
                245                 250                 255     


Thr His Glu Leu Ala Ala Glu Ala Ala Gly Asn Leu Val Gly Pro Arg 
            260                 265                 270         


Asp Phe Val Ser Val Arg Cys Ala Lys Arg Arg Gly Ser Thr Cys Val 
        275                 280                 285             


Leu Ala Gly Met Ala Thr Asp Phe Gly Asn Met Pro Glu Gln Lys Gly 
    290                 295                 300                 


Val Ile Arg Ala Glu His Gly Pro Thr Cys Met Val Leu His Pro Leu 
305                 310                 315                 320 


Ala Gly Ser Pro Ser Lys Thr Lys Leu Thr Trp Leu Leu Ser Ile Asp 
                325                 330                 335     


Leu Lys Gly Trp Leu Pro Lys Ser Ile Ile Asn Gln Val Leu Ser Gln 
            340                 345                 350         


Thr Gln Val Asp Phe Ala Asn His Leu Arg Lys Arg Leu Glu Ser His 
        355                 360                 365             


Pro Ala Ser Glu Ala Arg Cys 
    370                 375 


<210> 10
<211> 418
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Met Leu Leu Ala Thr Phe Lys Leu Cys Ala Gly Ser Ser Tyr Arg His 
1               5                   10                  15      


Met Arg Asn Met Lys Gly Leu Arg Gln Gln Ala Val Met Ala Ile Ser 
            20                  25                  30          


Gln Glu Leu Asn Arg Arg Ala Leu Gly Gly Pro Thr Pro Ser Thr Trp 
        35                  40                  45              


Ile Asn Gln Val Arg Arg Arg Ser Ser Leu Leu Gly Ser Arg Leu Glu 
    50                  55                  60                  


Glu Thr Leu Tyr Ser Asp Gln Glu Leu Ala Tyr Leu Gln Gln Gly Glu 
65                  70                  75                  80  


Glu Ala Met Gln Lys Ala Leu Gly Ile Leu Ser Asn Gln Glu Gly Trp 
                85                  90                  95      


Lys Lys Glu Ser Gln Gln Asp Asn Gly Asp Lys Val Met Ser Lys Val 
            100                 105                 110         


Val Pro Asp Val Gly Lys Val Phe Arg Leu Glu Val Val Val Asp Gln 
        115                 120                 125             


Pro Met Glu Arg Leu Tyr Glu Glu Leu Val Glu Arg Met Glu Ala Met 
    130                 135                 140                 


Gly Glu Trp Asn Pro Asn Val Lys Glu Ile Lys Val Leu Gln Lys Ile 
145                 150                 155                 160 


Gly Lys Asp Thr Phe Ile Thr His Glu Leu Ala Ala Glu Ala Ala Gly 
                165                 170                 175     


Asn Leu Val Gly Pro Arg Asp Phe Val Ser Val Arg Gly Ser Asp Asp 
            180                 185                 190         


Asp Asp Lys Leu Glu Glu Thr Leu Tyr Ser Asp Gln Glu Leu Ala Tyr 
        195                 200                 205             


Leu Gln Gln Gly Glu Glu Ala Met Gln Lys Ala Leu Gly Ile Leu Ser 
    210                 215                 220                 


Asn Gln Glu Gly Trp Lys Lys Glu Ser Gln Gln Asp Asn Gly Asp Lys 
225                 230                 235                 240 


Val Met Ser Lys Val Val Pro Asp Val Gly Lys Val Phe Arg Leu Glu 
                245                 250                 255     


Val Val Val Asp Gln Pro Met Glu Arg Leu Tyr Glu Glu Leu Val Glu 
            260                 265                 270         


Arg Met Glu Ala Met Gly Glu Trp Asn Pro Asn Val Lys Glu Ile Lys 
        275                 280                 285             


Val Leu Gln Lys Ile Gly Lys Asp Thr Phe Ile Thr His Glu Leu Ala 
    290                 295                 300                 


Ala Glu Ala Ala Gly Asn Leu Val Gly Pro Arg Asp Phe Val Ser Val 
305                 310                 315                 320 


Arg Cys Ala Lys Arg Arg Gly Ser Thr Cys Val Leu Ala Gly Met Ala 
                325                 330                 335     


Thr Asp Phe Gly Asn Met Pro Glu Gln Lys Gly Val Ile Arg Ala Glu 
            340                 345                 350         


His Gly Pro Thr Cys Met Val Leu His Pro Leu Ala Gly Ser Pro Ser 
        355                 360                 365             


Lys Thr Lys Leu Thr Trp Leu Leu Ser Ile Asp Leu Lys Gly Trp Leu 
    370                 375                 380                 


Pro Lys Ser Ile Ile Asn Gln Val Leu Ser Gln Thr Gln Val Asp Phe 
385                 390                 395                 400 


Ala Asn His Leu Arg Lys Arg Leu Glu Ser His Pro Ala Ser Glu Ala 
                405                 410                 415     


Arg Cys 
        


<210> 11
<211> 2565
<212> DNA
<213> Homo sapiens

<400> 11
gcagctgcgg gactcagagg cgaagcttga ggggctcagg aaggacgaag aaccaccctt       60

gagagaagag gcagcagcag cggcggcagc agcagcggca gcgaccccac cactgccaca      120

tttgccagga aacaatgctg ctagcgacat tcaagctgtg cgctgggagc tcctacagac      180

acatgcgcaa catgaagggg ctgaggcaac aggctgtgat ggccatcagc caggagctga      240

accggagggc cctggggggc cccaccccta gcacgtggat taaccaggtt cggcggcgga      300

gctctctact cggttctcgg ctggaagaga ctctctacag tgaccaggag ctggcctatc      360

tccagcaggg ggaggaggcc atgcagaagg ccttgggcat ccttagcaac caagagggct      420

ggaagaagga gagtcagcag gacaatgggg acaaagtgat gagtaaagtg gtcccagatg      480

tgggcaaggt gttccggctg gaggtcgtgg tggaccagcc catggagagg ctctatgaag      540

agctcgtgga gcgcatggaa gcaatggggg agtggaaccc caatgtcaag gagatcaagg      600

tcctgcagaa gatcggaaaa gatacattca ttactcacga gctggctgcc gaggcagcag      660

gaaacctggt ggggccccgt gactttgtga gcgtgcgctg tgccaagcgc cgaggctcca      720

cctgtgtgct ggctggcatg gccacagact tcgggaacat gcctgagcag aagggtgtca      780

tcagggcgga gcacggtccc acttgcatgg tgcttcaccc gttggctgga agtccctcta      840

agaccaaact tacgtggcta ctcagcatcg acctcaaggg gtggctgccc aagagcatca      900

tcaaccaggt cctgtcccag acccaggtgg attttgccaa ccacctgcgc aagcgcctgg      960

agtcccaccc tgcctctgaa gccaggtgtt gaagaccagc ctgctgttcc caactgtgcc     1020

cagctgcact ggtacacacg ctcatcagga gaatccctac tggaagcctg caagtctaag     1080

atctccatct ggtgacagtg ggatgggtgg ggttcgtgtt tagagtatga cactaggatt     1140

cagattggtg aaagttttta gtaccaagaa aacagggatg aggctcttgg attaaaaggt     1200

aacttcattc actgattagc tatgacatga gggttcaggc ccctaaaata attgtaaaac     1260

tttttttctg ggcccttatg tacccaccta aaaccatctt taaaatgcta gtggctgata     1320

tgggtgtggg ggatgctaac cacagggcct gagaagtctt gctttatggg ctcaagaatg     1380

ccatgcgctg gcagtacatg tgcacaaagc agaatctcag agggtctcct gcagccctct     1440

gctcctcccg gccgctgcac agcaacacca cagaacaagc agcaccccac agtgggtgcc     1500

ttccagaaat atagtccaag ctttctctgt ggaaaaagac aaaactcatt agtagacatg     1560

tttccctatt gctttcatag gcaccagtca gaataaagaa tcataattca cacaaacatc     1620

agtctttgtt ttaatattgt actgttaaaa aaatctatgc agctgggtgc agtggctcac     1680

gcctgtaatc ccagcatttt gggaggctga ggtaggcgga tcacaaggtc aggagatcga     1740

gaccatcctg gccaacatgg tgaaaccccg tctctactaa aatacaaaaa attagctggg     1800

tgtggtggcg caaacctgta gtcgtagcta cttgggaggc tgaggcaggg gaatcacttg     1860

aaccccggag gcggaggttg tagtgggccg agattgtgcc actgcgctcc agcgtgggcg     1920

acagagtgag actccatctc aaaaaaaaaa aaaaaaaaat ctatgctagt agattacaac     1980

ttcacactag aggagttctg gacaaagctt ttaattagtc aaactaaatt aaggctcatt     2040

aaaaggaaag gaactactgg gaaattatgc aattcaataa tttagactct gttaccagga     2100

tctttcataa aaatttaatt tccataatca taacctaaat gagttcttaa agaattctat     2160

aagcaatagc tgattaatgg gccctggaag atgaagatta taactgttta tttacctaat     2220

taaaaggaaa ggcagtgcca aatatgagag gataaacaat attagttaac atttctgtta     2280

tttatgatgc caattagtag taagataatt ccacagctgt caactttgtt tggggctggc     2340

aacttctctg cttaaacagg ctaaaagttt agtattctgg gagaagtggc tggaagaagg     2400

ggtaatatgg tgaaagcaaa ttccctttcc caggagtcaa gagaatttat gtgaggtggc     2460

tcccgcctgt aatctcagca ctttgggagg ccaaggcagg caatcacctg agggcaggag     2520

accagcctga ctaacatgga gaaaccccat ctctactaaa aatac                     2565


<210> 12
<211> 3283
<212> DNA
<213> Homo sapiens

<400> 12
ctttctgtgt tcctggcccg cggccgtcgg gtgtgagctg cgccgaccgc tctgagggtt       60

cgtggcccac cgctccttcg cggtccctgc cgccaccgtc cacgctcagc gttgtagaga      120

agatggtggg tcggaacagc gccatcgccg ccggtgtatg cggggccctt ttcattgggt      180

actgcatcta cttcgaccgc aaaagacgaa gtgaccccaa cttcaagaac aggcttcgag      240

aacgaagaaa gaaacagaag cttgccaagg agagagctgg gctttccaag ttacctgacc      300

ttaaagatgc tgaagctgtt cagaagttct tccttgaaga aatacagctt ggtgaagagt      360

tactagctca aggtgaatat gagaagggcg tagaccatct gacaaatgca attgctgtgt      420

gtggacagcc acagcagtta ctgcaggtct tacagcaaac tcttccacca ccagtgttcc      480

agatgcttct gactaagctc ccaacaatta gtcagagaat tgtaagtgct cagagcttgg      540

ctgaagatga tgtggaatga gaaacaaatg tcaacataat aaaatctcag ttaaaaatat      600

tttaaaaatt cttggtagtt gagcagctct gggggaataa gggcaaatat gcttgttatg      660

aactacactg aaatctacca aagttaatgt ttactttgtg tagatccatt tgtctatttt      720

atttattttt cccagtgaaa agtgtatttt gatagagaac ttttcattct ataaatacac      780

tatgagttac taaaatatca tggattttgt ttattcctga aacatagtta catagttaaa      840

ctgtacatat gacatggctt atgttaaaaa tacccagtgc tcagttttga aagataggca      900

aaaaaaaaaa agtataggag aaactgaaga atgtacactt ttttagaggg cacattttgc      960

tgtaaatctg gaaatttgat agacttgact gtgtttgtga aaactgagca ttaaaggttt     1020

tgattgatcc tttctttcca tttaatctct gagacgtaaa tatgtgaggt gtgctgctgt     1080

gctgggttaa cagcttcctt ccctttctgt gtagcagtct tgaaatgttc tgtttaaatc     1140

agtaggctta atgtgttctg ggtatttatc tccttgtatt ttaaatatat gtagttgcaa     1200

atagcaccag gaattagatt tctgtacacc cctaatctag ccttgtgagc ttcgctagtt     1260

aatgtgtgct cactttccct ccatttgtta cgtgagagaa tgcgtctgct gatcactgaa     1320

gtgtcccttt tagcttctga ttcattgggt tctgttgggc atctttaaat ccaccttaac     1380

ctgaggaatg tatgtgggca accaggccct gcattttttt atattctgaa ttttgcatgc     1440

ttgcctgact tagtatttct gaattgatgt tttttttaat ggtataacta tcttgatttt     1500

cactgaaatt atatggttct gtcactactc tgtaaattaa tccgaaactt ttaaggtaac     1560

tgggatgatc tgcttgtaaa aatgcttgtt gccttttgct ttatcttcag tgtacctcct     1620

taatcctgct tcaacttgat tatcttgtga aacgatgaga gtaagttgca accttgtgac     1680

tgaaaacttg aaaagagtgg agcaggtggg acctcttatt ctcaaatagt gacatattct     1740

ccgtagtcac agtttcagaa ctgagtaagg atccttggta cttggtggca tctgttgaac     1800

tgaggagcat ttctcattgt aaagattgcc tttgttctgt ctaaaagtct ggagaaatcc     1860

caaagacttt tcctatgtac taggcatttt attttgattg acttacaaac tcttcttaat     1920

cattatcaat ctcggttttt ttgtggtgca gtggaaggag aaataggtct agtttctgcc     1980

tctgattagc cgcacagcct tgaacaaatc acatttcatc tttgaactta cctctactgt     2040

tagactaggc gactcacatt tgaggacttt tctcgggtat cttgagggtt tgtgatcctg     2100

aacccttaaa cagtgctttt ttgttacaca ggagggcttt tttgggggga tgaccagtac     2160

agacatgcca gttagtttta ctagtgggat cccaaatcca aagcagtgta gtggtgattg     2220

gtcagtgact aaccaggcag ctaagaagtc ttaggcagca gcccagacat gtatagaggg     2280

gcagttagag ggagaacagg ggtgggaaag ggagcaaggg gcagatagct cagcaaggaa     2340

agaatgggct cagaaaaagg agggctggct ggaggagtga ggggcagctt aagtttgggg     2400

agggtagaaa cgccgtttcc ttgggaactg gagtgcagta tgagctgggt gtcacttggc     2460

tctgaacata ctggctttgc tgtaatgctt gaaaaggcgt tggtatcttc attttacagt     2520

tcattaaccc aagtacgttt tcttatttaa atgacaactt tggtgcttta aaatgaggta     2580

ccacttttta aagctagctg tgtcgagtta aagaaaaaat cagcagtttt ttctcccaga     2640

aatgtaattg ccaaacacta ttcatcccca tcttaagttt tacaaggtga tgtaatcagc     2700

ttgttgtagt gatgctggcc aaatggtgct cagcaggtga gaacaaaaaa accccagatc     2760

tcagtgaact aatacacagc ttgagcgttt ccatgtgcta atgttgcaca cttactaaaa     2820

aactttggaa atggaaaata atgtattagt gcaacagttg atgtgcttct ttgggcaaag     2880

atatagtttt gttccacaat ttgtacttaa aagcgaaaga acattgaaaa catagactta     2940

ctggctgtag caatgctggc ctgttaactg ataactagaa cttaggttca cgtttatgta     3000

aagtgtgtaa aacctagtag agcttgcata gtcggcactc agtaaatgtt tggttccttt     3060

tgccccttgg taagtttatt ttaccatcct cccacctgcc attctgactt tattaaatca     3120

acatgtggac cagagtgtta atgagatgtt attgcagaag agattgagaa aattggtata     3180

tcatgcagat aacatacaaa atctttttgt aacgtaaaaa atgcagtttt attattgctt     3240

gtgcctcaac tgtttaagtg aatattaaag ggcttggaga aaa                       3283


