                         SEQUENCE LISTING

<110>  Spitfire Pharma
 
<120>  Therapeutic Regimens and Methods for Lowering Blood Glucose 
       and/or Body Weight using GLP-1R and GCGR Balanced Agonists

<130>  MED008.PCT

<150>  63/122,117
<151>  2021-12-07

<150>  63/211,157
<151>  2021-06-16

<150>  63/249,468
<151>  2021-09-28

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  30
<212>  PRT
<213>  Artificial squence

<220>
<223>  Synthetic Peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Glu side chain lactam linkage to Lys

<220>
<221>  SITE
<222>  (16)..(20)
<223>  cyclic

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Z17CO2H

<220>
<221>  SITE
<222>  (20)..(20)
<223>  Lys side chain lactam linkage to Glu

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  NH2

<400>  1

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Ala Ala Lys Glu Phe Ile Gln Trp Leu Leu Gln Thr Xaa 
            20                  25                  30  


<210>  2
<211>  30
<212>  PRT
<213>  Artificial squence

<220>
<223>  Synthetic Peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Glu side chain lactam linkage to Lys

<220>
<221>  SITE
<222>  (16)..(20)
<223>  cyclic

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Me15CO2H

<220>
<221>  SITE
<222>  (20)..(20)
<223>  Lys side chain lactam linkage to Glu

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  NH2

<400>  2

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Ala Ala Lys Glu Phe Ile Gln Trp Leu Leu Gln Thr Xaa 
            20                  25                  30  


<210>  3
<211>  30
<212>  PRT
<213>  Artificial squence

<220>
<223>  Synthetic Peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Glu side chain lactam linkage to Lys

<220>
<221>  SITE
<222>  (16)..(20)
<223>  cyclic

<220>
<221>  SITE
<222>  (20)..(20)
<223>  Lys side chain lactam linkage to Glu

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Z15CO2H

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  NH2

<400>  3

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Lys Trp Leu Leu Gln Thr Xaa 
            20                  25                  30  


<210>  4
<211>  30
<212>  PRT
<213>  Artificial squence

<220>
<223>  Synthetic Peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Glu side chain lactam linkage to Lys

<220>
<221>  SITE
<222>  (16)..(20)
<223>  cyclic

<220>
<221>  SITE
<222>  (20)..(20)
<223>  Lys side chain lactam linkage to Glu

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Z17CO2H

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  NH2

<400>  4

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Lys Trp Leu Leu Gln Thr Xaa 
            20                  25                  30  


<210>  5
<211>  30
<212>  PRT
<213>  Artificial squence

<220>
<223>  Synthetic Peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Glu side chain lactam linkage to Lys

<220>
<221>  SITE
<222>  (16)..(20)
<223>  cyclic

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Z17CO2H

<220>
<221>  SITE
<222>  (20)..(20)
<223>  Lys side chain lactam linkage to Glu

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  NH2

<400>  5

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Ala Ala Lys Glu Phe Ile Gln Trp Leu Leu Gln Thr Xaa 
            20                  25                  30  


<210>  6
<211>  29
<212>  PRT
<213>  Artificial squence

<220>
<223>  Synthetic Peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  SITE
<222>  (16)..(20)
<223>  cyclic

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Glu side chain lactam linkage to Lys

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Lys(N-omega(1-(17-carboxyl-heptadecyloxy)beta-D-glucuronyl)) or 
       Lys(Z17CO2H)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  Lys side chain lactam linkage to Glu

<400>  6

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Xaa Ala Ala Lys Glu Phe Ile Gln Trp Leu Leu Gln Thr 
            20                  25                  


<210>  7
<211>  29
<212>  PRT
<213>  Artificial squence

<220>
<223>  Synthetic Peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  SITE
<222>  (16)..(20)
<223>  cyclic

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Glu side chain lactam linkage to Lys

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Me17CO2H

<220>
<221>  SITE
<222>  (20)..(20)
<223>  Lys side chain lactam linkage to Glu

<400>  7

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Xaa Ala Ala Lys Glu Phe Ile Gln Trp Leu Leu Gln Thr 
            20                  25                  


<210>  8
<211>  29
<212>  PRT
<213>  Artificial squence

<220>
<223>  Synthetic Peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  SITE
<222>  (16)..(20)
<223>  cyclic

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Glu side chain lactam linkage to Lys

<220>
<221>  SITE
<222>  (20)..(20)
<223>  Lys side chain lactam linkage to Glu

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Lys(Z15CO2H)

<400>  8

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Xaa Trp Leu Leu Gln Thr 
            20                  25                  


<210>  9
<211>  29
<212>  PRT
<213>  Artificial squence

<220>
<223>  Synthetic Peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  SITE
<222>  (16)..(20)
<223>  cyclic

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Glu side chain lactam linkage to Lys

<220>
<221>  SITE
<222>  (20)..(20)
<223>  Lys side chain lactam linkage to Glu

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Lys(Z17CO2H)

<400>  9

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Xaa Trp Leu Leu Gln Thr 
            20                  25                  


<210>  10
<211>  29
<212>  PRT
<213>  Artificial squence

<220>
<223>  Synthetic Peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Arg

<220>
<221>  SITE
<222>  (16)..(20)
<223>  cyclic

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Glu side chain lactam linkage to Lys

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Lys(N-omega(1-(17-carboxyl-heptadecyloxy)beta-D-glucuronyl)) or 
       Lys(Z17CO2H)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  Lys side chain lactam linkage to Glu

<400>  10

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Tyr Leu Asp Glu 
1               5                   10                  15      


Xaa Ala Ala Lys Glu Phe Ile Gln Trp Leu Leu Gln Thr 
            20                  25                  


<210>  11
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Lys(yGlu-2xOEG)

<400>  11

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      

