                               SEQUENCE LISTING

<110> THE JOHNS HOPKINS UNIVERSITY
 
<120> METHODS OF NK CELL ENGINEERING TO ENHANCE TUMOR TARGETING

<130> 048317-616001WO

<140> PCT/US2021/062251
<141> 2021-12-07

<150> 63/122,442
<151> 2020-12-07

<160> 31    

<170> PatentIn version 3.5

<210> 1
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1
Gln Asp Cys Gln Asn Ala His Gln Glu Phe Arg Phe Trp Pro 
1               5                   10                  


<210> 2
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 2
Leu Gly Glu Pro Gln 
1               5   


<210> 3
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro Gly 
1               5                   10                  15      


Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro 
            20                  25                  30  


<210> 4
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Trp Arg Arg Lys Arg Lys Glu Lys Gln Ser Glu Thr Ser Pro Lys Glu 
1               5                   10                  15      


Phe Leu Thr Ile Tyr Glu Asp Val Lys Asp Leu Lys Thr Arg Arg Asn 
            20                  25                  30          


His Glu Gln Glu Gln Thr Phe Pro Gly Gly Gly Ser Thr Ile Tyr Ser 
        35                  40                  45              


Met Ile Gln Ser Gln Ser Ser Ala Pro Thr Ser Gln Glu Pro Ala Tyr 
    50                  55                  60                  


Thr Leu Tyr Ser Leu Ile Gln Pro Ser Arg Lys Ser Gly Ser Arg Lys 
65                  70                  75                  80  


Arg Asn His Ser Pro Ser Phe Asn Ser Thr Ile Tyr Glu Val Ile Gly 
                85                  90                  95      


Lys Ser Gln Pro Lys Ala Gln Asn Pro Ala Arg Leu Ser Arg Lys Glu 
            100                 105                 110         


Leu Glu Asn Phe Asp Val Tyr Ser 
        115                 120 


<210> 5
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Phe Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Phe Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Phe Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210> 6
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210> 7
<211> 44
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        35                  40                  


<210> 8
<211> 42
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Arg Leu Lys Ile Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys 
1               5                   10                  15      


Ser Asp Gly Val Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr 
            20                  25                  30          


Glu Thr Leu Lys His Glu Lys Pro Pro Gln 
        35                  40          


<210> 9
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys Val 
1               5                   10                  15      


Tyr Ile Asn Met Pro Gly Arg Gly 
            20                  


<210> 10
<211> 165
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Met Ala Thr Thr Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile 
1               5                   10                  15      


Gln Cys Tyr Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala 
            20                  25                  30          


Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys 
        35                  40                  45              


Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu 
    50                  55                  60                  


Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser 
65                  70                  75                  80  


Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu 
                85                  90                  95      


Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp 
            100                 105                 110         


Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn 
        115                 120                 125             


Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
    130                 135                 140                 


Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met 
145                 150                 155                 160 


Phe Ile Asn Thr Ser 
                165 


<210> 11
<211> 162
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Met Arg Ser Ser Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met 
1               5                   10                  15      


Val Ile Phe Leu Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln 
            20                  25                  30          


Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln 
        35                  40                  45              


Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro 
    50                  55                  60                  


Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln 
65                  70                  75                  80  


Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile 
                85                  90                  95      


Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala 
            100                 105                 110         


Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr 
        115                 120                 125             


Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu 
    130                 135                 140                 


Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu 
145                 150                 155                 160 


Asp Ser 
        


<210> 12
<211> 586
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 12
cccctctccc tccccccccc ctaacgttac tggccgaagc cgcttggaat aaggccggtg       60

tgcgtttgtc tatatgttat tttccaccat attgccgtct tttggcaatg tgagggcccg      120

gaaacctggc cctgtcttct tgacgagcat tcctaggggt ctttcccctc tcgccaaagg      180

aatgcaaggt ctgttgaatg tcgtgaagga agcagttcct ctggaagctt cttgaagaca      240

aacaacgtct gtagcgaccc tttgcaggca gcggaacccc ccacctggcg acaggtgcct      300

ctgcggccaa aagccacgtg tataagatac acctgcaaag gcggcacaac cccagtgcca      360

cgttgtgagt tggatagttg tggaaagagt caaatggctc tcctcaagcg tattcaacaa      420

ggggctgaag gatgcccaga aggtacccca ttgtatggga tctgatctgg ggcctcggtg      480

cacatgcttt acatgtgttt agtcgaggtt aaaaaacgtc taggcccccc gaaccacggg      540

gacgtggttt tcctttgaaa aacacgatga taatatggcc acaacc                     586


<210> 13
<211> 193
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 13
Met Ala Ala Glu Pro Val Glu Asp Asn Cys Ile Asn Phe Val Ala Met 
1               5                   10                  15      


Lys Phe Ile Asp Asn Thr Leu Tyr Phe Ile Ala Glu Asp Asp Glu Asn 
            20                  25                  30          


Leu Glu Ser Asp Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile 
        35                  40                  45              


Arg Asn Leu Asn Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro 
    50                  55                  60                  


Leu Phe Glu Asp Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg 
65                  70                  75                  80  


Thr Ile Phe Ile Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met 
                85                  90                  95      


Ala Val Thr Ile Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys 
            100                 105                 110         


Glu Asn Lys Ile Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile 
        115                 120                 125             


Lys Asp Thr Lys Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly 
    130                 135                 140                 


His Asp Asn Lys Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe 
145                 150                 155                 160 


Leu Ala Cys Glu Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys 
                165                 170                 175     


Glu Asp Glu Leu Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu 
            180                 185                 190         


Asp 
    


<210> 14
<211> 219
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val Leu Leu 
1               5                   10                  15      


Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            20                  25                  30          


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        35                  40                  45              


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    50                  55                  60                  


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
65                  70                  75                  80  


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                85                  90                  95      


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            100                 105                 110         


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        115                 120                 125             


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    130                 135                 140                 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
145                 150                 155                 160 


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                165                 170                 175     


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            180                 185                 190         


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        195                 200                 205             


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
    210                 215                 


<210> 15
<211> 153
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 15
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210> 16
<211> 45
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210> 17
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Asp Phe Leu Pro Thr Thr Ala Gln Pro Thr Lys Lys Ser Thr Leu Lys 
1               5                   10                  15      


Lys Arg Val Cys Arg Leu Pro Arg Pro Glu Thr Gln Lys Gly Pro Leu 
            20                  25                  30          


Cys Ser Pro 
        35  


<210> 18
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Pro Phe Phe Phe Cys Cys Phe Ile Ala Val Ala Met Gly Ile Arg Phe 
1               5                   10                  15      


Ile Ile Met Val Ala 
            20      


<210> 19
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210> 20
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Ile Thr Leu Gly Leu Leu Val Ala Gly Val Leu Val Leu Leu Val Ser 
1               5                   10                  15      


Leu Gly Val Ala Ile 
            20      


<210> 21
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Asp 
1               5                   10                  15      


<210> 22
<211> 464
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Asp Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Asn Trp Asp Asp Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu 
145                 150                 155                 160 


Ala Ala Ser Pro Gly Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys 
                165                 170                 175     


Ser Ile Ser Lys Asp Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr 
            180                 185                 190         


Asn Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro 
        195                 200                 205             


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
    210                 215                 220                 


Ser Ser Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His 
225                 230                 235                 240 


Asn Lys Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gln Asp Cys Gln Asn Ala His Gln Glu Phe 
            260                 265                 270         


Arg Phe Trp Pro Phe Leu Val Ile Ile Val Ile Leu Ser Ala Leu Phe 
        275                 280                 285             


Leu Gly Thr Leu Ala Cys Phe Cys Val Trp Arg Arg Lys Arg Lys Glu 
    290                 295                 300                 


Lys Gln Ser Glu Thr Ser Pro Lys Glu Phe Leu Thr Ile Tyr Glu Asp 
305                 310                 315                 320 


Val Lys Asp Leu Lys Thr Arg Arg Asn His Glu Gln Glu Gln Thr Phe 
                325                 330                 335     


Pro Gly Gly Gly Ser Thr Ile Tyr Ser Met Ile Gln Ser Gln Ser Ser 
            340                 345                 350         


Ala Pro Thr Ser Gln Glu Pro Ala Tyr Thr Leu Tyr Ser Leu Ile Gln 
        355                 360                 365             


Pro Ser Arg Lys Ser Gly Ser Arg Lys Arg Asn His Ser Pro Ser Phe 
    370                 375                 380                 


Asn Ser Thr Ile Tyr Glu Val Ile Gly Lys Ser Gln Pro Lys Ala Gln 
385                 390                 395                 400 


Asn Pro Ala Arg Leu Ser Arg Lys Glu Leu Glu Asn Phe Asp Val Tyr 
                405                 410                 415     


Ser Gly Ala Gly Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            420                 425                 430         


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        435                 440                 445             


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    450                 455                 460                 


<210> 23
<211> 533
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Asp Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Asn Trp Asp Asp Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu 
145                 150                 155                 160 


Ala Ala Ser Pro Gly Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys 
                165                 170                 175     


Ser Ile Ser Lys Asp Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr 
            180                 185                 190         


Asn Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro 
        195                 200                 205             


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
    210                 215                 220                 


Ser Ser Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His 
225                 230                 235                 240 


Asn Lys Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gln Asp Cys Gln Asn Ala His Gln Glu Phe 
            260                 265                 270         


Arg Phe Trp Pro Phe Leu Val Ile Ile Val Ile Leu Ser Ala Leu Phe 
        275                 280                 285             


Leu Gly Thr Leu Ala Cys Phe Cys Val Trp Arg Arg Lys Arg Lys Glu 
    290                 295                 300                 


Lys Gln Ser Glu Thr Ser Pro Lys Glu Phe Leu Thr Ile Tyr Glu Asp 
305                 310                 315                 320 


Val Lys Asp Leu Lys Thr Arg Arg Asn His Glu Gln Glu Gln Thr Phe 
                325                 330                 335     


Pro Gly Gly Gly Ser Thr Ile Tyr Ser Met Ile Gln Ser Gln Ser Ser 
            340                 345                 350         


Ala Pro Thr Ser Gln Glu Pro Ala Tyr Thr Leu Tyr Ser Leu Ile Gln 
        355                 360                 365             


Pro Ser Arg Lys Ser Gly Ser Arg Lys Arg Asn His Ser Pro Ser Phe 
    370                 375                 380                 


Asn Ser Thr Ile Tyr Glu Val Ile Gly Lys Ser Gln Pro Lys Ala Gln 
385                 390                 395                 400 


Asn Pro Ala Arg Leu Ser Arg Lys Glu Leu Glu Asn Phe Asp Val Tyr 
                405                 410                 415     


Ser Gly Ala Gly Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            420                 425                 430         


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        435                 440                 445             


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    450                 455                 460                 


Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Phe 
465                 470                 475                 480 


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Phe Ser Glu Ile Gly 
                485                 490                 495     


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln 
            500                 505                 510         


Gly Leu Ser Thr Ala Thr Lys Asp Thr Phe Asp Ala Leu His Met Gln 
        515                 520                 525             


Ala Leu Pro Pro Arg 
    530             


<210> 24
<211> 533
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Asp Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Asn Trp Asp Asp Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu 
145                 150                 155                 160 


Ala Ala Ser Pro Gly Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys 
                165                 170                 175     


Ser Ile Ser Lys Asp Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr 
            180                 185                 190         


Asn Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro 
        195                 200                 205             


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
    210                 215                 220                 


Ser Ser Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His 
225                 230                 235                 240 


Asn Lys Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gln Asp Cys Gln Asn Ala His Gln Glu Phe 
            260                 265                 270         


Arg Phe Trp Pro Phe Leu Val Ile Ile Val Ile Leu Ser Ala Leu Phe 
        275                 280                 285             


Leu Gly Thr Leu Ala Cys Phe Cys Val Trp Arg Arg Lys Arg Lys Glu 
    290                 295                 300                 


Lys Gln Ser Glu Thr Ser Pro Lys Glu Phe Leu Thr Ile Tyr Glu Asp 
305                 310                 315                 320 


Val Lys Asp Leu Lys Thr Arg Arg Asn His Glu Gln Glu Gln Thr Phe 
                325                 330                 335     


Pro Gly Gly Gly Ser Thr Ile Tyr Ser Met Ile Gln Ser Gln Ser Ser 
            340                 345                 350         


Ala Pro Thr Ser Gln Glu Pro Ala Tyr Thr Leu Tyr Ser Leu Ile Gln 
        355                 360                 365             


Pro Ser Arg Lys Ser Gly Ser Arg Lys Arg Asn His Ser Pro Ser Phe 
    370                 375                 380                 


Asn Ser Thr Ile Tyr Glu Val Ile Gly Lys Ser Gln Pro Lys Ala Gln 
385                 390                 395                 400 


Asn Pro Ala Arg Leu Ser Arg Lys Glu Leu Glu Asn Phe Asp Val Tyr 
                405                 410                 415     


Ser Gly Ala Gly Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            420                 425                 430         


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        435                 440                 445             


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    450                 455                 460                 


Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
465                 470                 475                 480 


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
                485                 490                 495     


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
            500                 505                 510         


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
        515                 520                 525             


Ala Leu Pro Pro Arg 
    530             


<210> 25
<211> 42
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210> 26
<211> 237
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Asp Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Trp Asp Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser 
    130                 135                 140                 


Pro Gly Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser 
145                 150                 155                 160 


Lys Asp Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu 
                165                 170                 175     


Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe 
            180                 185                 190         


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
        195                 200                 205             


Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn Lys Tyr 
    210                 215                 220                 


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
225                 230                 235         


<210> 27
<211> 2702
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 27
atggactgga tctggcgcat cctgtttctc gtgggagccg ccacaggcgc ccattctcag       60

gtgcagctgc agcagcctgg cgctgaactc gtgcggccag gcgcttctgt gaagctgagc      120

tgtaaagcca gcggctacac cttcaccagc tactggatga actgggtcaa gcagcggccc      180

gaccagggcc tggaatggat cggaagaatc gacccctacg acagcgagac acactacaac      240

cagaagttca aggacaaggc catcctgacc gtggacaaga gcagcagcac cgcctacatg      300

cagctgtcca gcctgaccag cgaggacagc gccgtgtact actgcgccag aggcaactgg      360

gacgactact ggggccaggg cacaaccctg acagtgtcta gcggaggcgg aggaagtggc      420

ggcggaggat ctgggggagg cggatctgat gtgcagatca cccagagccc cagctacctg      480

gctgcctctc ctggcgagac aatcaccatc aactgccggg ccagcaagag catctccaag      540

gacctggcct ggtatcagga aaagcccggc aagaccaaca agctgctgat ctacagcggc      600

agcaccctgc agagcggcat ccccagcaga ttttccggca gcggctccgg caccgacttc      660

accctgacaa tcagctccct ggaacccgag gactttgcca tgtactattg ccagcagcac      720

aacaagtacc cttacacctt cggcggaggc accaagctgg aaatcaagag cggagggggc      780

ggatcccagg attgccagaa tgcccaccaa gagttccggt tctggccctt cctggtcatc      840

atcgtgatcc tgagcgccct gttcctgggc accctggcct gtttttgcgt gtggcgcaga      900

aagcgcaaag agaagcagag cgagacaagc cccaaagagt tcctgaccat ctacgaggac      960

gtgaaggacc tgaaaacccg gcggaaccac gagcaagagc agacctttcc tggcggcgga     1020

agcaccatct acagcatgat ccagagccag agcagcgccc ctacaagcca agagcctgcc     1080

tacacactgt actccctgat ccagcctagc agaaagagcg gcagccggaa gagaaatcac     1140

agccccagct tcaacagcac gatctacgaa gtgatcggca agagccagcc aaaggctcag     1200

aaccctgcca gactgagccg gaaagagctg gaaaacttcg acgtgtactc tggggccggc     1260

agagtgaagt tcagcagatc agccgatgct cccgcctatc agcagggcca gaaccagctg     1320

tacaacgagc tgaacctggg gagaagagaa gagtacgacg tgctggacaa gcggagaggc     1380

agagatcctg agatgggcgg aaagccccag cggagaaaga atcctcaaga gggcctgtat     1440

aatgagctgc agaaagacaa gatggccgag gcctacagcg agatcggaat gaagggcgag     1500

cgcagaagag gcaagggaca cgatggactg taccagggcc tgagcaccgc caccaaggat     1560

acctatgatg ccctgcacat gcaggccctg cctccaagat gagcggccgc cgcatgctac     1620

gtaaattccg cccctctccc tccccccccc ctaacgttac tggccgaagc cgcttggaat     1680

aaggccggtg tgcgtttgtc tatatgttat tttccaccat attgccgtct tttggcaatg     1740

tgagggcccg gaaacctggc cctgtcttct tgacgagcat tcctaggggt ctttcccctc     1800

tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga agcagttcct ctggaagctt     1860

cttgaagaca aacaacgtct gtagcgaccc tttgcaggca gcggaacccc ccacctggcg     1920

acaggtgcct ctgcggccaa aagccacgtg tataagatac acctgcaaag gcggcacaac     1980

cccagtgcca cgttgtgagt tggatagttg tggaaagagt caaatggctc tcctcaagcg     2040

tattcaacaa ggggctgaag gatgcccaga aggtacccca ttgtatggga tctgatctgg     2100

ggcctcggtg cacatgcttt acatgtgttt agtcgaggtt aaaaaacgtc taggcccccc     2160

gaaccacggg gacgtggttt tcctttgaaa aacacgatga taatatggcc acaaccagga     2220

tcagcaagcc ccacctgaga tccatcagca tccagtgcta cctgtgcctg ctgctgaaca     2280

gccacttcct gacagaggcc ggaatccatg tgttcatcct gggctgcttt agcgccggac     2340

tgcctaagac cgaagccaac tgggtcaacg tgatcagcga cctgaagaag atcgaggacc     2400

tgatccagag catgcacatc gacgccacac tgtacaccga gtccgatgtg caccccagct     2460

gtaaagtgac cgccatgaag tgctttctgc tggaactgca agtgatcagc ctggaaagcg     2520

gcgacgccag catccacgac accgtggaaa acctgatcat cctggccaac aacagcctga     2580

gcagcaacgg caatgtgacc gagagcggct gcaaagagtg cgaggaactg gaagagaaga     2640

atatcaaaga gttcctgcag agcttcgtcc acatcgtgca gatgttcatc aacaccagct     2700

ga                                                                    2702


<210> 28
<211> 1809
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 28
atgaggatca gcaagcccca cctgagatcc atcagcatcc agtgctacct gtgcctgctg       60

ctgaacagcc acttcctgac agaggccgga atccatgtgt tcatcctggg ctgctttagc      120

gccggactgc ctaagaccga agccaactgg gtcaacgtga tcagcgacct gaagaagatc      180

gaggacctga tccagagcat gcacatcgac gccacactgt acaccgagtc cgatgtgcac      240

cccagctgta aagtgaccgc catgaagtgc tttctgctgg aactgcaagt gatcagcctg      300

gaaagcggcg acgccagcat ccacgacacc gtggaaaacc tgatcatcct ggccaacaac      360

agcctgagca gcaacggcaa tgtgaccgag agcggctgca aagagtgcga ggaactggaa      420

gagaagaata tcaaagagtt cctgcagagc ttcgtccaca tcgtgcagat gttcatcaac      480

accagctgag cggccgccgc atgctacgta aattccgccc ctctccctcc ccccccccta      540

acgttactgg ccgaagccgc ttggaataag gccggtgtgc gtttgtctat atgttatttt      600

ccaccatatt gccgtctttt ggcaatgtga gggcccggaa acctggccct gtcttcttga      660

cgagcattcc taggggtctt tcccctctcg ccaaaggaat gcaaggtctg ttgaatgtcg      720

tgaaggaagc agttcctctg gaagcttctt gaagacaaac aacgtctgta gcgacccttt      780

gcaggcagcg gaacccccca cctggcgaca ggtgcctctg cggccaaaag ccacgtgtat      840

aagatacacc tgcaaaggcg gcacaacccc agtgccacgt tgtgagttgg atagttgtgg      900

aaagagtcaa atggctctcc tcaagcgtat tcaacaaggg gctgaaggat gcccagaagg      960

taccccattg tatgggatct gatctggggc ctcggtgcac atgctttaca tgtgtttagt     1020

cgaggttaaa aaacgtctag gccccccgaa ccacggggac gtggttttcc tttgaaaaac     1080

acgatgataa tatggccaca agttagcaag ggtgaggaga ataacatggc gatcattaag     1140

gaatttatgc gctttaaggt ccggatggag ggatcagtga atggtcacga gttcgagatc     1200

gagggcgagg gagaaggaag accttacgag ggcttccaga ccgcaaaact gaaagttact     1260

aaaggcggcc cactcccctt cgcctgggat attctcagtc cgcaattcac atacggctct     1320

aaggcgtatg taaaacaccc tgccgacatc cctgactact tcaagctcag ctttcccgag     1380

ggctttaagt gggaacgggt catgaatttt gaagatggag gagtcgttac agtgacccaa     1440

gattcttcat tgcaggatgg cgagttcatt tataaggtga agctcagggg caccaacttc     1500

ccctcagatg ggccagtgat gcagaaaaag actatgggct gggaagctag ctccgagcgc     1560

atgtacccag aggatggcgc gctcaaaggg gagattaaga tgagactgaa actgaaggac     1620

ggaggacact atactagtga ggtaaagact acgtacaaag caaagaaacc cgtccagctt     1680

cctggagcgt acatcgtggg cattaaactc gatattactt cacacaacga ggactacacc     1740

atcgtggagc aatatgagcg agccgagggt agacacagta caggcggaat ggacgagctt     1800

tacaagtga                                                             1809


<210> 29
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 29
Phe Leu Val Ile Ile Val Ile Leu Ser Ala Leu Phe Leu Gly Thr Leu 
1               5                   10                  15      


Ala Cys Phe Cys Val 
            20      


<210> 30
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Leu Cys Tyr Ile Leu Asp Ala Ile Leu Phe Leu Tyr Gly Ile Val Leu 
1               5                   10                  15      


Thr Leu Leu Tyr Cys 
            20      


<210> 31
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 31
Leu Leu Ala Gly Leu Val Ala Ala Asp Ala Val Ala Ser Leu Leu Ile 
1               5                   10                  15      


Val Gly Ala Val Phe 
            20      


