                               SEQUENCE LISTING

<110> MEMORIAL SLOAN KETTERING CANCER CENTER
      TRI-INSTITUTIONAL THERAPEUTICS DISCOVERY INSTITUTE, INC.
 
<120> ANTIBODIES TO GALECTIN-3 AND METHODS OF USE THEREOF

<130> 115872-2370

<140> PCT/US2021/062099
<141> 2021-12-07

<150> 63/122,714
<151> 2020-12-08

<160> 58    

<170> PatentIn version 3.5

<210> 1
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 2
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 2
Gln Ser Leu Val Tyr Ser Asp Gly Asn Thr Tyr 
1               5                   10      


<210> 3
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Lys Val Ser 
1           


<210> 4
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Met Gln Gly Thr His Trp Pro Leu Thr 
1               5                   


<210> 5
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5
gatgtggtga tgactcagag tccgctcagc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca ggtctagtca aagcctcgta tacagtgatg gaaacaccta cttgaattgg      120

tttcagcaga ggccaggcca atctccaagg cgcctaattt ataaggtttc taaccgggac      180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggggtt tattactgca tgcaaggtac acactggcct      300

ctcactttcg gcggagggac caaggtggag atcaaa                                336


<210> 6
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro His Ser Gly Gly Thr Asn Ser Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Gly Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Asn Pro Ile Thr Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210> 7
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Gly Tyr Thr Phe Thr Gly Tyr Ser 
1               5               


<210> 8
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Ile Asn Pro His Ser Gly Gly Thr 
1               5               


<210> 9
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Val Arg Asp Asn Pro Ile Thr Gly Phe Asp Tyr 
1               5                   10      


<210> 10
<211> 355
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 10
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc ggctattcta tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaaccctc acagtggtgg cacaaattct      180

gcacagaagt ttcagggcag ggtcaccatg accagggaca cgtccatcgg cacagcctac      240

atggagctga acaggctgag atctgacgac acggccgtgt attactgtgt gagagataac      300

cctataactg ggtttgacta ctggggccag ggaaccctgg tcaccgtctc ctcag           355


<210> 11
<211> 958
<212> DNA
<213> Homo sapiens

<400> 11
gcccgcagca cctcctcgcc agcagccgtc cggagccagc caacgagcgg aaaatggcag       60

acaatttttc gctccatgat gcgttatctg ggtctggaaa cccaaaccct caaggatggc      120

ctggcgcatg ggggaaccag cctgctgggg cagggggcta cccaggggct tcctatcctg      180

gggcctaccc cgggcaggca cccccagggg cttatcctgg acaggcacct ccaggcgcct      240

accctggagc acctggagct tatcccggag cacctgcacc tggagtctac ccagggccac      300

ccagcggccc tggggcctac ccatcttctg gacagccaag tgccaccgga gcctaccctg      360

ccactggccc ctatggcgcc cctgctgggc cactgattgt gccttataac ctgcctttgc      420

ctgggggagt ggtgcctcgc atgctgataa caattctggg cacggtgaag cccaatgcaa      480

acagaattgc tttagatttc caaagaggga atgatgttgc cttccacttt aacccacgct      540

tcaatgagaa caacaggaga gtcattgttt gcaatacaaa gctggataat aactggggaa      600

gggaagaaag acagtcggtt ttcccatttg aaagtgggaa accattcaaa atacaagtac      660

tggttgaacc tgaccacttc aaggttgcag tgaatgatgc tcacttgttg cagtacaatc      720

atcgggttaa aaaactcaat gaaatcagca aactgggaat ttctggtgac atagacctca      780

ccagtgcttc atataccatg atataatctg aaaggggcag attaaaaaaa aaaaaagaat      840

ctaaacctta catgtgtaaa ggtttcatgt tcactgtgag tgaaaatttt tacattcatc      900

aatatccctc ttgtaagtca tctacttaat aaatattaca gtgaattacc tgtctcaa        958


<210> 12
<211> 250
<212> PRT
<213> Homo sapiens

<400> 12
Met Ala Asp Asn Phe Ser Leu His Asp Ala Leu Ser Gly Ser Gly Asn 
1               5                   10                  15      


Pro Asn Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly 
            20                  25                  30          


Ala Gly Gly Tyr Pro Gly Ala Ser Tyr Pro Gly Ala Tyr Pro Gly Gln 
        35                  40                  45              


Ala Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr Pro 
    50                  55                  60                  


Gly Ala Pro Gly Ala Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro 
65                  70                  75                  80  


Gly Pro Pro Ser Gly Pro Gly Ala Tyr Pro Ser Ser Gly Gln Pro Ser 
                85                  90                  95      


Ala Thr Gly Ala Tyr Pro Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly 
            100                 105                 110         


Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro 
        115                 120                 125             


Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg 
    130                 135                 140                 


Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn 
145                 150                 155                 160 


Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys 
                165                 170                 175     


Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe 
            180                 185                 190         


Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp His 
        195                 200                 205             


Phe Lys Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg 
    210                 215                 220                 


Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile 
225                 230                 235                 240 


Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile 
                245                 250 


<210> 13
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 13
Glu Thr Thr Val Thr Gln Ser Pro Ala Ser Leu Ser Met Ala Ile Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Arg Cys Ile Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Glu Gly Asn Ile Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Ser 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Val Phe Ala Ile Glu Asn Met Leu Ser 
65                  70                  75                  80  


Glu Asp Val Ala Asp Tyr Tyr Cys Leu Gln Ser Asp Asn Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210> 14
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Thr Asp Ile Asp Asp Asp 
1               5       


<210> 15
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Glu Gly Asn 
1           


<210> 16
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Leu Gln Ser Asp Asn Leu Pro Tyr Thr 
1               5                   


<210> 17
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 17
gaaacaactg tgacccagtc tccagcatcc ctgtccatgg ctataggaga aaaagtcacc       60

atcagatgca taaccagcac tgatattgat gatgatatga actggtacca gcagaagcca      120

ggggaacctc ctaagctcct tatttcagaa ggcaatattc ttcgtcctgg agtcccatcc      180

cgattctcca gcagtggcta cggtacagat tttgtttttg caattgaaaa catgctctca      240

gaagatgttg cagattacta ctgtttgcaa agtgataact tgccgtacac gttcggaggg      300

gggaccaagc tggaactaaa a                                                321


<210> 18
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr 
            20                  25                  30          


Asn Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Cys Val Ser Arg Ser Asn Tyr Thr Tyr Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Cys Gly Thr Tyr Gly Val Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210> 19
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Gly Phe Ile Phe Ser Asn Tyr Asn 
1               5               


<210> 20
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Cys Val Ser Arg Ser Asn Tyr Thr 
1               5               


<210> 21
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Ala Arg Asp Cys Gly Thr Tyr Gly Val Phe Asp Tyr 
1               5                   10          


<210> 22
<211> 355
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 22
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt tatattcagt aattataata taaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatgt gttagtagga gtaattacac atactacaca      180

gactcagtga agggccgatt caccatctcc agagacaacg ccaagaagtc actgtatctg      240

caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag agactgtggg      300

acctatgggg tctttgacta ttggggccag ggaaccctgg tcaccgtctc ctcag           355


<210> 23
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Glu Thr Thr Val Thr Gln Ser Pro Ala Ser Leu Ser Met Ala Ile Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Arg Cys Ile Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Glu Gly Asn Ile Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Ser 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Val Phe Ala Ile Glu Asn Met Leu Ser 
65                  70                  75                  80  


Glu Asp Val Ala Asp Tyr Tyr Cys Leu Gln Ser Asp Asn Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210> 24
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Thr Asp Ile Asp Asp Asp 
1               5       


<210> 25
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Glu Gly Asn 
1           


<210> 26
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 26
Leu Gln Ser Asp Asn Leu Pro Tyr Thr 
1               5                   


<210> 27
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 27
gaaacaactg tgacccagtc tccagcatcc ctgtccatgg ctataggaga aaaagtcacc       60

atcagatgca taaccagcac tgatattgat gatgatatga actggtacca gcagaagcca      120

ggggaacctc ctaagctcct tatttcagaa ggcaatattc ttcgtcctgg agtcccatcc      180

cgattctcca gcagtggcta cggtacagat tttgtttttg caattgaaaa catgctctca      240

gaagatgttg cagattacta ctgtttgcaa agtgataact tgccgtacac gttcggaggg      300

gggaccaagc tggaactaaa a                                                321


<210> 28
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 28
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr 
            20                  25                  30          


Asn Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Cys Val Ser Arg Ser Asn Tyr Thr Tyr Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Cys Gly Thr Tyr Gly Val Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210> 29
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 29
Gly Phe Ile Phe Ser Asn Tyr Asn 
1               5               


<210> 30
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Cys Val Ser Arg Ser Asn Tyr Thr 
1               5               


<210> 31
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 31
Ala Arg Asp Cys Gly Thr Tyr Gly Val Phe Asp Tyr 
1               5                   10          


<210> 32
<211> 355
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 32
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt tatattcagt aattataata taaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatgt gttagtagga gtaattacac atactacaca      180

gactcagtga agggccgatt caccatctcc agagacaacg ccaagaagtc actgtatctg      240

caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag agactgtggg      300

acctatgggg tctttgacta ttggggccag ggaaccctgg tcaccgtctc ctcag           355


<210> 33
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Leu Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Gly 
            20                  25                  30          


Asp Asp Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Leu Tyr Trp Ala Ser Thr Trp Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Ala Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210> 34
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 34
Gln Ser Leu Leu Tyr Gly Asp Asp Gln Lys Asn Tyr 
1               5                   10          


<210> 35
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 35
Trp Ala Ser 
1           


<210> 36
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 36
Gln Gln Tyr Tyr Ser Tyr Pro Trp Thr 
1               5                   


<210> 37
<211> 339
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 37
gacattgtga tgtcacagtc tccatcctcc ctagctgtgt cagttggaga gaaggttact       60

ctgagctgca agtccagtca gagcctttta tatggtgacg atcaaaagaa ctacttggcc      120

tggtaccaac agaaaccagg acagtctcct aaactgcttc tttactgggc atccacttgg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgaaggctgc agacctggca gtttattact gtcagcaata ttatagctat      300

ccgtggacgt tcggtggagg caccaagctg gaaatcaaa                             339


<210> 38
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Gly Thr Tyr Asn Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Ala Trp Ile Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210> 39
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 39
Gly Phe Thr Leu Ser Asn Tyr Ala 
1               5               


<210> 40
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 40
Ile Ser Gly Ser Gly Gly Gly Thr 
1               5               


<210> 41
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 41
Ala Lys Glu Ala Trp Ile Ser Tyr Phe Asp Tyr 
1               5                   10      


<210> 42
<211> 355
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 42
gaagtacagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacccttagt aactatgcca tgagctgggt ccgccaggcg      120

ccagggaagg ggctggagtg ggtctcagct atcagtggta gtggtggtgg cacatacaac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gaaagaggcg      300

tggatctcgt actttgacta ctggggccag gggaccctgg tcaccgtctc ctcag           355


<210> 43
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 43
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Leu Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Gly 
            20                  25                  30          


Asp Asp Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Leu Tyr Trp Ala Ser Thr Trp Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Ala Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210> 44
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 44
Gln Ser Leu Leu Tyr Gly Asp Asp Gln Lys Asn Tyr 
1               5                   10          


<210> 45
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 45
Trp Ala Ser 
1           


<210> 46
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 46
Gln Gln Tyr Tyr Ser Tyr Pro Trp Thr 
1               5                   


<210> 47
<211> 339
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 47
gacattgtga tgtcacagtc tccatcctcc ctagctgtgt cagttggaga gaaggttact       60

ctgagctgca agtccagtca gagcctttta tatggtgacg atcaaaagaa ctacttggcc      120

tggtaccaac agaaaccagg acagtctcct aaactgcttc tttactgggc atccacttgg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgaaggctgc agacctggca gtttattact gtcagcaata ttatagctat      300

ccgtggacgt tcggtggagg caccaagctg gaaatcaaa                             339


<210> 48
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 48
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Gly Thr Tyr Asn Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Ala Trp Ile Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210> 49
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 49
Gly Phe Thr Leu Ser Asn Tyr Ala 
1               5               


<210> 50
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 50
Ile Ser Gly Ser Gly Gly Gly Thr 
1               5               


<210> 51
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 51
Ala Lys Glu Ala Trp Ile Ser Tyr Phe Asp Tyr 
1               5                   10      


<210> 52
<211> 355
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 52
gaagtacagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacccttagt aactatgcca tgagctgggt ccgccaggcg      120

ccagggaagg ggctggagtg ggtctcagct atcagtggta gtggtggtgg cacatacaac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gaaagaggcg      300

tggatctcgt actttgacta ctggggccag gggaccctgg tcaccgtctc ctcag           355


<210> 53
<211> 249
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      GAL-3 immunogen sequnce

<400> 53
Ala Asp Asn Phe Ser Leu His Asp Ala Leu Ser Gly Ser Gly Asn Pro 
1               5                   10                  15      


Asn Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly Ala 
            20                  25                  30          


Gly Gly Tyr Pro Gly Ala Ser Tyr Pro Gly Ala Tyr Pro Gly Gln Ala 
        35                  40                  45              


Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr Pro Gly 
    50                  55                  60                  


Ala Pro Gly Ala Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro Gly 
65                  70                  75                  80  


Pro Pro Ser Gly Pro Gly Ala Tyr Pro Ser Ser Gly Gln Pro Ser Ala 
                85                  90                  95      


Thr Gly Ala Tyr Pro Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly Pro 
            100                 105                 110         


Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro Arg 
        115                 120                 125             


Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg Ile 
    130                 135                 140                 


Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn Pro 
145                 150                 155                 160 


Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys Leu 
                165                 170                 175     


Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe Glu 
            180                 185                 190         


Ser Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp His Phe 
        195                 200                 205             


Lys Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg Val 
    210                 215                 220                 


Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile Asp 
225                 230                 235                 240 


Leu Thr Ser Ala Ser Tyr Thr Met Ile 
                245                 


<210> 54
<211> 128
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      LGALS3 sequence

<400> 54
Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro Arg Met Leu Ile 
1               5                   10                  15      


Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg Ile Ala Leu Asp 
            20                  25                  30          


Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn Pro Arg Phe Asn 
        35                  40                  45              


Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys Leu Asp Asn Asn 
    50                  55                  60                  


Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe Glu Ser Gly Lys 
65                  70                  75                  80  


Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp His Phe Lys Val Ala 
                85                  90                  95      


Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg Val Lys Lys Leu 
            100                 105                 110         


Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile Asp Leu Thr Ser 
        115                 120                 125             


<210> 55
<211> 384
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      LGALS3 sequence

<400> 55
ccttataacc tgcctttgcc tgggggagtg gtgcctcgca tgctgataac aattctgggc       60

acggtgaagc ccaatgcaaa cagaattgct ttagatttcc aaagagggaa tgatgttgcc      120

ttccacttta acccacgctt caatgagaac aacaggagag tcattgtttg caatacaaag      180

ctggataata actggggaag ggaagaaaga cagtcggttt tcccatttga aagtgggaaa      240

ccattcaaaa tacaagtact ggttgaacct gaccacttca aggttgcagt gaatgatgct      300

cacttgttgc agtacaatca tcgggttaaa aaactcaatg aaatcagcaa actgggaatt      360

tctggtgaca tagacctcac cagt                                             384


<210> 56
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 56
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 57
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 57
His His His His His His 
1               5       


<210> 58
<211> 44
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      LGALS3 sequence

<400> 58
Gly Asn Asp Val Ala Phe His Phe Asn Pro Arg Phe Asn Glu Asn Asn 
1               5                   10                  15      


Arg Arg Val Ile Val Cys Asn Thr Lys Leu Asp Asn Asn Trp Gly Arg 
            20                  25                  30          


Glu Glu Arg Gln Ser Val Phe Pro Phe Glu Ser Gly 
        35                  40                  


