                         SEQUENCE LISTING

<110>  CITY OF HOPE
       MORRIS, Kevin V.
       VILLAMIZAR BELTRAN, Olga Raquel
 
<120>  COMPOUNDS AND METHODS TO TREAT CYSTIC FIBROSIS

<130>  048440-789001WO

<150>  63/123,413
<151>  2020-12-09

<160>  33    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  1
gggatgggcc tggtgctggg c                                                 21


<210>  2
<211>  765
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  2

Met Asp Tyr Lys Asp Asp Asp Asp Lys Lys Arg Pro Ala Ala Thr Lys 
1               5                   10                  15      


Lys Ala Gly Gln Ala Lys Lys Lys Lys Leu Glu Pro Gly Glu Lys Pro 
            20                  25                  30          


Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Ser Lys Lys Ala Leu 
        35                  40                  45              


Thr Glu His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro 
    50                  55                  60                  


Glu Cys Gly Lys Ser Phe Ser Arg Ala Asp Asn Leu Thr Glu His Gln 
65                  70                  75                  80  


Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys 
                85                  90                  95      


Ser Phe Ser Arg Ser Asp His Leu Thr Asn His Gln Arg Thr His Thr 
            100                 105                 110         


Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Asp 
        115                 120                 125             


Lys Lys Asp Leu Thr Arg His Gln Arg Thr His Thr Gly Glu Lys Pro 
    130                 135                 140                 


Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Arg Ser Asp Lys Leu 
145                 150                 155                 160 


Thr Glu His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro 
                165                 170                 175     


Glu Cys Gly Lys Ser Phe Ser Asp Pro Gly His Leu Val Arg His Gln 
            180                 185                 190         


Arg Thr His Thr Gly Lys Lys Thr Ser Ser Ala Ala Asp Pro Lys Lys 
        195                 200                 205             


Lys Arg Lys Val Ser Pro Gly Ile Arg Arg Leu Asp Ala Leu Ile Ser 
    210                 215                 220                 


Thr Ser Leu Tyr Lys Lys Ala Gly Tyr Lys Glu Ala Ser Gly Ser Gly 
225                 230                 235                 240 


Arg Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp 
                245                 250                 255     


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp 
            260                 265                 270         


Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp 
        275                 280                 285             


Leu Asp Met Leu Ile Asn Ser Arg Ser Ser Gly Ser Pro Lys Lys Lys 
    290                 295                 300                 


Arg Lys Val Gly Ser Gln Tyr Leu Pro Asp Thr Asp Asp Arg His Arg 
305                 310                 315                 320 


Ile Glu Glu Lys Arg Lys Arg Thr Tyr Glu Thr Phe Lys Ser Ile Met 
                325                 330                 335     


Lys Lys Ser Pro Phe Ser Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg 
            340                 345                 350         


Arg Ile Ala Val Pro Ser Arg Ser Ser Ala Ser Val Pro Lys Pro Ala 
        355                 360                 365             


Pro Gln Pro Tyr Pro Phe Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp 
    370                 375                 380                 


Glu Phe Pro Thr Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser 
385                 390                 395                 400 


Ala Leu Ala Pro Ala Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro 
                405                 410                 415     


Ala Pro Ala Pro Ala Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro 
            420                 425                 430         


Val Pro Val Leu Ala Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala 
        435                 440                 445             


Pro Lys Pro Thr Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu 
    450                 455                 460                 


Gln Leu Gln Phe Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser 
465                 470                 475                 480 


Thr Asp Pro Ala Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu 
                485                 490                 495     


Phe Gln Gln Leu Leu Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr 
            500                 505                 510         


Glu Pro Met Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr 
        515                 520                 525             


Gly Ala Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro 
    530                 535                 540                 


Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe Ser Ser Ile 
545                 550                 555                 560 


Ala Asp Met Asp Phe Ser Ala Leu Leu Gly Ser Gly Ser Gly Ser Arg 
                565                 570                 575     


Asp Ser Arg Glu Gly Met Phe Leu Pro Lys Pro Glu Ala Gly Ser Ala 
            580                 585                 590         


Ile Ser Asp Val Phe Glu Gly Arg Glu Val Cys Gln Pro Lys Arg Ile 
        595                 600                 605             


Arg Pro Phe His Pro Pro Gly Ser Pro Trp Ala Asn Arg Pro Leu Pro 
    610                 615                 620                 


Ala Ser Leu Ala Pro Thr Pro Thr Gly Pro Val His Glu Pro Val Gly 
625                 630                 635                 640 


Ser Leu Thr Pro Ala Pro Val Pro Gln Pro Leu Asp Pro Ala Pro Ala 
                645                 650                 655     


Val Thr Pro Glu Ala Ser His Leu Leu Glu Asp Pro Asp Glu Glu Thr 
            660                 665                 670         


Ser Gln Ala Val Lys Ala Leu Arg Glu Met Ala Asp Thr Val Ile Pro 
        675                 680                 685             


Gln Lys Glu Glu Ala Ala Ile Cys Gly Gln Met Asp Leu Ser His Pro 
    690                 695                 700                 


Pro Pro Arg Gly His Leu Asp Glu Leu Thr Thr Thr Leu Glu Ser Met 
705                 710                 715                 720 


Thr Glu Asp Leu Asn Leu Asp Ser Pro Leu Thr Pro Glu Leu Asn Glu 
                725                 730                 735     


Ile Leu Asp Thr Phe Leu Asn Asp Glu Cys Leu Leu His Ala Met His 
            740                 745                 750         


Ile Ser Thr Gly Leu Ser Ile Phe Asp Thr Ser Leu Phe 
        755                 760                 765 


<210>  3
<211>  757
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  3

Met Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys 
1               5                   10                  15      


Lys Leu Glu Pro Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys 
            20                  25                  30          


Ser Phe Ser Ser Lys Lys Ala Leu Thr Glu His Gln Arg Thr His Thr 
        35                  40                  45              


Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Arg 
    50                  55                  60                  


Ala Asp Asn Leu Thr Glu His Gln Arg Thr His Thr Gly Glu Lys Pro 
65                  70                  75                  80  


Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Arg Ser Asp His Leu 
                85                  90                  95      


Thr Asn His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro 
            100                 105                 110         


Glu Cys Gly Lys Ser Phe Ser Asp Lys Lys Asp Leu Thr Arg His Gln 
        115                 120                 125             


Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys 
    130                 135                 140                 


Ser Phe Ser Arg Ser Asp Lys Leu Thr Glu His Gln Arg Thr His Thr 
145                 150                 155                 160 


Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Asp 
                165                 170                 175     


Pro Gly His Leu Val Arg His Gln Arg Thr His Thr Gly Lys Lys Thr 
            180                 185                 190         


Ser Ser Ala Ala Asp Pro Lys Lys Lys Arg Lys Val Ser Pro Gly Ile 
        195                 200                 205             


Arg Arg Leu Asp Ala Leu Ile Ser Thr Ser Leu Tyr Lys Lys Ala Gly 
    210                 215                 220                 


Tyr Lys Glu Ala Ser Gly Ser Gly Arg Ala Asp Ala Leu Asp Asp Phe 
225                 230                 235                 240 


Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp 
                245                 250                 255     


Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly 
            260                 265                 270         


Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Ile Asn Ser Arg 
        275                 280                 285             


Ser Ser Gly Ser Pro Lys Lys Lys Arg Lys Val Gly Ser Gln Tyr Leu 
    290                 295                 300                 


Pro Asp Thr Asp Asp Arg His Arg Ile Glu Glu Lys Arg Lys Arg Thr 
305                 310                 315                 320 


Tyr Glu Thr Phe Lys Ser Ile Met Lys Lys Ser Pro Phe Ser Gly Pro 
                325                 330                 335     


Thr Asp Pro Arg Pro Pro Pro Arg Arg Ile Ala Val Pro Ser Arg Ser 
            340                 345                 350         


Ser Ala Ser Val Pro Lys Pro Ala Pro Gln Pro Tyr Pro Phe Thr Ser 
        355                 360                 365             


Ser Leu Ser Thr Ile Asn Tyr Asp Glu Phe Pro Thr Met Val Phe Pro 
    370                 375                 380                 


Ser Gly Gln Ile Ser Gln Ala Ser Ala Leu Ala Pro Ala Pro Pro Gln 
385                 390                 395                 400 


Val Leu Pro Gln Ala Pro Ala Pro Ala Pro Ala Pro Ala Met Val Ser 
                405                 410                 415     


Ala Leu Ala Gln Ala Pro Ala Pro Val Pro Val Leu Ala Pro Gly Pro 
            420                 425                 430         


Pro Gln Ala Val Ala Pro Pro Ala Pro Lys Pro Thr Gln Ala Gly Glu 
        435                 440                 445             


Gly Thr Leu Ser Glu Ala Leu Leu Gln Leu Gln Phe Asp Asp Glu Asp 
    450                 455                 460                 


Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro Ala Val Phe Thr Asp 
465                 470                 475                 480 


Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly 
                485                 490                 495     


Ile Pro Val Ala Pro His Thr Thr Glu Pro Met Leu Met Glu Tyr Pro 
            500                 505                 510         


Glu Ala Ile Thr Arg Leu Val Thr Gly Ala Gln Arg Pro Pro Asp Pro 
        515                 520                 525             


Ala Pro Ala Pro Leu Gly Ala Pro Gly Leu Pro Asn Gly Leu Leu Ser 
    530                 535                 540                 


Gly Asp Glu Asp Phe Ser Ser Ile Ala Asp Met Asp Phe Ser Ala Leu 
545                 550                 555                 560 


Leu Gly Ser Gly Ser Gly Ser Arg Asp Ser Arg Glu Gly Met Phe Leu 
                565                 570                 575     


Pro Lys Pro Glu Ala Gly Ser Ala Ile Ser Asp Val Phe Glu Gly Arg 
            580                 585                 590         


Glu Val Cys Gln Pro Lys Arg Ile Arg Pro Phe His Pro Pro Gly Ser 
        595                 600                 605             


Pro Trp Ala Asn Arg Pro Leu Pro Ala Ser Leu Ala Pro Thr Pro Thr 
    610                 615                 620                 


Gly Pro Val His Glu Pro Val Gly Ser Leu Thr Pro Ala Pro Val Pro 
625                 630                 635                 640 


Gln Pro Leu Asp Pro Ala Pro Ala Val Thr Pro Glu Ala Ser His Leu 
                645                 650                 655     


Leu Glu Asp Pro Asp Glu Glu Thr Ser Gln Ala Val Lys Ala Leu Arg 
            660                 665                 670         


Glu Met Ala Asp Thr Val Ile Pro Gln Lys Glu Glu Ala Ala Ile Cys 
        675                 680                 685             


Gly Gln Met Asp Leu Ser His Pro Pro Pro Arg Gly His Leu Asp Glu 
    690                 695                 700                 


Leu Thr Thr Thr Leu Glu Ser Met Thr Glu Asp Leu Asn Leu Asp Ser 
705                 710                 715                 720 


Pro Leu Thr Pro Glu Leu Asn Glu Ile Leu Asp Thr Phe Leu Asn Asp 
                725                 730                 735     


Glu Cys Leu Leu His Ala Met His Ile Ser Thr Gly Leu Ser Ile Phe 
            740                 745                 750         


Asp Thr Ser Leu Phe 
        755         


<210>  4
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  4

Met Leu Glu Pro Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys 
1               5                   10                  15      


Ser Phe Ser Ser Lys Lys Ala Leu Thr Glu His Gln Arg Thr His Thr 
            20                  25                  30          


Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Arg 
        35                  40                  45              


Ala Asp Asn Leu Thr Glu His Gln Arg Thr His Thr Gly Glu Lys Pro 
    50                  55                  60                  


Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Arg Ser Asp His Leu 
65                  70                  75                  80  


Thr Asn His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro 
                85                  90                  95      


Glu Cys Gly Lys Ser Phe Ser Asp Lys Lys Asp Leu Thr Arg His Gln 
            100                 105                 110         


Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys 
        115                 120                 125             


Ser Phe Ser Arg Ser Asp Lys Leu Thr Glu His Gln Arg Thr His Thr 
    130                 135                 140                 


Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Asp 
145                 150                 155                 160 


Pro Gly His Leu Val Arg His Gln Arg Thr His Thr Gly Lys Lys Thr 
                165                 170                 175     


Ser Ser Ala Ala Asp Pro Lys Lys Lys Arg Lys Val Ser Pro Gly Ile 
            180                 185                 190         


Arg Arg Leu Asp Ala Leu Ile Ser Thr Ser Leu Tyr Lys Lys Ala Gly 
        195                 200                 205             


Tyr Lys Glu Ala Ser Gly Ser Gly Arg Ala Asp Ala Leu Asp Asp Phe 
    210                 215                 220                 


Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp 
225                 230                 235                 240 


Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly 
                245                 250                 255     


Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Ile Asn Ser Arg 
            260                 265                 270         


Ser Ser Gly Ser Pro Lys Lys Lys Arg Lys Val Gly Ser Gln Tyr Leu 
        275                 280                 285             


Pro Asp Thr Asp Asp Arg His Arg Ile Glu Glu Lys Arg Lys Arg Thr 
    290                 295                 300                 


Tyr Glu Thr Phe Lys Ser Ile Met Lys Lys Ser Pro Phe Ser Gly Pro 
305                 310                 315                 320 


Thr Asp Pro Arg Pro Pro Pro Arg Arg Ile Ala Val Pro Ser Arg Ser 
                325                 330                 335     


Ser Ala Ser Val Pro Lys Pro Ala Pro Gln Pro Tyr Pro Phe Thr Ser 
            340                 345                 350         


Ser Leu Ser Thr Ile Asn Tyr Asp Glu Phe Pro Thr Met Val Phe Pro 
        355                 360                 365             


Ser Gly Gln Ile Ser Gln Ala Ser Ala Leu Ala Pro Ala Pro Pro Gln 
    370                 375                 380                 


Val Leu Pro Gln Ala Pro Ala Pro Ala Pro Ala Pro Ala Met Val Ser 
385                 390                 395                 400 


Ala Leu Ala Gln Ala Pro Ala Pro Val Pro Val Leu Ala Pro Gly Pro 
                405                 410                 415     


Pro Gln Ala Val Ala Pro Pro Ala Pro Lys Pro Thr Gln Ala Gly Glu 
            420                 425                 430         


Gly Thr Leu Ser Glu Ala Leu Leu Gln Leu Gln Phe Asp Asp Glu Asp 
        435                 440                 445             


Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro Ala Val Phe Thr Asp 
    450                 455                 460                 


Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly 
465                 470                 475                 480 


Ile Pro Val Ala Pro His Thr Thr Glu Pro Met Leu Met Glu Tyr Pro 
                485                 490                 495     


Glu Ala Ile Thr Arg Leu Val Thr Gly Ala Gln Arg Pro Pro Asp Pro 
            500                 505                 510         


Ala Pro Ala Pro Leu Gly Ala Pro Gly Leu Pro Asn Gly Leu Leu Ser 
        515                 520                 525             


Gly Asp Glu Asp Phe Ser Ser Ile Ala Asp Met Asp Phe Ser Ala Leu 
    530                 535                 540                 


Leu Gly Ser Gly Ser Gly Ser Arg Asp Ser Arg Glu Gly Met Phe Leu 
545                 550                 555                 560 


Pro Lys Pro Glu Ala Gly Ser Ala Ile Ser Asp Val Phe Glu Gly Arg 
                565                 570                 575     


Glu Val Cys Gln Pro Lys Arg Ile Arg Pro Phe His Pro Pro Gly Ser 
            580                 585                 590         


Pro Trp Ala Asn Arg Pro Leu Pro Ala Ser Leu Ala Pro Thr Pro Thr 
        595                 600                 605             


Gly Pro Val His Glu Pro Val Gly Ser Leu Thr Pro Ala Pro Val Pro 
    610                 615                 620                 


Gln Pro Leu Asp Pro Ala Pro Ala Val Thr Pro Glu Ala Ser His Leu 
625                 630                 635                 640 


Leu Glu Asp Pro Asp Glu Glu Thr Ser Gln Ala Val Lys Ala Leu Arg 
                645                 650                 655     


Glu Met Ala Asp Thr Val Ile Pro Gln Lys Glu Glu Ala Ala Ile Cys 
            660                 665                 670         


Gly Gln Met Asp Leu Ser His Pro Pro Pro Arg Gly His Leu Asp Glu 
        675                 680                 685             


Leu Thr Thr Thr Leu Glu Ser Met Thr Glu Asp Leu Asn Leu Asp Ser 
    690                 695                 700                 


Pro Leu Thr Pro Glu Leu Asn Glu Ile Leu Asp Thr Phe Leu Asn Asp 
705                 710                 715                 720 


Glu Cys Leu Leu His Ala Met His Ile Ser Thr Gly Leu Ser Ile Phe 
                725                 730                 735     


Asp Thr Ser Leu Phe 
            740     


<210>  5
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  5

Met Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys 
1               5                   10                  15      


Lys Leu Glu Pro Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys 
            20                  25                  30          


Ser Phe Ser Ser Lys Lys Ala Leu Thr Glu His Gln Arg Thr His Thr 
        35                  40                  45              


Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Arg 
    50                  55                  60                  


Ala Asp Asn Leu Thr Glu His Gln Arg Thr His Thr Gly Glu Lys Pro 
65                  70                  75                  80  


Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Arg Ser Asp His Leu 
                85                  90                  95      


Thr Asn His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro 
            100                 105                 110         


Glu Cys Gly Lys Ser Phe Ser Asp Lys Lys Asp Leu Thr Arg His Gln 
        115                 120                 125             


Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys 
    130                 135                 140                 


Ser Phe Ser Arg Ser Asp Lys Leu Thr Glu His Gln Arg Thr His Thr 
145                 150                 155                 160 


Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Asp 
                165                 170                 175     


Pro Gly His Leu Val Arg His Gln Arg Thr His Thr Gly Lys Lys Thr 
            180                 185                 190         


Ser Ser Pro Lys Lys Lys Arg Lys Val Ser Gly Ser Gly Asp Ala Leu 
        195                 200                 205             


Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe 
    210                 215                 220                 


Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp 
225                 230                 235                 240 


Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Ser 
                245                 250                 255     


Ser Gly Ser Pro Lys Lys Lys Arg Lys Val Gly Ser Gln Tyr Leu Pro 
            260                 265                 270         


Asp Thr Asp Asp Arg His Arg Ile Glu Glu Lys Arg Lys Arg Thr Tyr 
        275                 280                 285             


Glu Thr Phe Lys Ser Ile Met Lys Lys Ser Pro Phe Ser Gly Pro Thr 
    290                 295                 300                 


Asp Pro Arg Pro Pro Pro Arg Arg Ile Ala Val Pro Ser Arg Ser Ser 
305                 310                 315                 320 


Ala Ser Val Pro Lys Pro Ala Pro Gln Pro Tyr Pro Phe Thr Ser Ser 
                325                 330                 335     


Leu Ser Thr Ile Asn Tyr Asp Glu Phe Pro Thr Met Val Phe Pro Ser 
            340                 345                 350         


Gly Gln Ile Ser Gln Ala Ser Ala Leu Ala Pro Ala Pro Pro Gln Val 
        355                 360                 365             


Leu Pro Gln Ala Pro Ala Pro Ala Pro Ala Pro Ala Met Val Ser Ala 
    370                 375                 380                 


Leu Ala Gln Ala Pro Ala Pro Val Pro Val Leu Ala Pro Gly Pro Pro 
385                 390                 395                 400 


Gln Ala Val Ala Pro Pro Ala Pro Lys Pro Thr Gln Ala Gly Glu Gly 
                405                 410                 415     


Thr Leu Ser Glu Ala Leu Leu Gln Leu Gln Phe Asp Asp Glu Asp Leu 
            420                 425                 430         


Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro Ala Val Phe Thr Asp Leu 
        435                 440                 445             


Ala Ser Val Asp Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly Ile 
    450                 455                 460                 


Pro Val Ala Pro His Thr Thr Glu Pro Met Leu Met Glu Tyr Pro Glu 
465                 470                 475                 480 


Ala Ile Thr Arg Leu Val Thr Gly Ala Gln Arg Pro Pro Asp Pro Ala 
                485                 490                 495     


Pro Ala Pro Leu Gly Ala Pro Gly Leu Pro Asn Gly Leu Leu Ser Gly 
            500                 505                 510         


Asp Glu Asp Phe Ser Ser Ile Ala Asp Met Asp Phe Ser Ala Leu Leu 
        515                 520                 525             


Gly Ser Gly Ser Gly Ser Arg Asp Ser Arg Glu Gly Met Phe Leu Pro 
    530                 535                 540                 


Lys Pro Glu Ala Gly Ser Ala Ile Ser Asp Val Phe Glu Gly Arg Glu 
545                 550                 555                 560 


Val Cys Gln Pro Lys Arg Ile Arg Pro Phe His Pro Pro Gly Ser Pro 
                565                 570                 575     


Trp Ala Asn Arg Pro Leu Pro Ala Ser Leu Ala Pro Thr Pro Thr Gly 
            580                 585                 590         


Pro Val His Glu Pro Val Gly Ser Leu Thr Pro Ala Pro Val Pro Gln 
        595                 600                 605             


Pro Leu Asp Pro Ala Pro Ala Val Thr Pro Glu Ala Ser His Leu Leu 
    610                 615                 620                 


Glu Asp Pro Asp Glu Glu Thr Ser Gln Ala Val Lys Ala Leu Arg Glu 
625                 630                 635                 640 


Met Ala Asp Thr Val Ile Pro Gln Lys Glu Glu Ala Ala Ile Cys Gly 
                645                 650                 655     


Gln Met Asp Leu Ser His Pro Pro Pro Arg Gly His Leu Asp Glu Leu 
            660                 665                 670         


Thr Thr Thr Leu Glu Ser Met Thr Glu Asp Leu Asn Leu Asp Ser Pro 
        675                 680                 685             


Leu Thr Pro Glu Leu Asn Glu Ile Leu Asp Thr Phe Leu Asn Asp Glu 
    690                 695                 700                 


Cys Leu Leu His Ala Met His Ile Ser Thr Gly Leu Ser Ile Phe Asp 
705                 710                 715                 720 


Thr Ser Leu Phe 
                


<210>  6
<211>  708
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  6

Met Leu Glu Pro Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys 
1               5                   10                  15      


Ser Phe Ser Ser Lys Lys Ala Leu Thr Glu His Gln Arg Thr His Thr 
            20                  25                  30          


Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Arg 
        35                  40                  45              


Ala Asp Asn Leu Thr Glu His Gln Arg Thr His Thr Gly Glu Lys Pro 
    50                  55                  60                  


Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Arg Ser Asp His Leu 
65                  70                  75                  80  


Thr Asn His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro 
                85                  90                  95      


Glu Cys Gly Lys Ser Phe Ser Asp Lys Lys Asp Leu Thr Arg His Gln 
            100                 105                 110         


Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys 
        115                 120                 125             


Ser Phe Ser Arg Ser Asp Lys Leu Thr Glu His Gln Arg Thr His Thr 
    130                 135                 140                 


Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Asp 
145                 150                 155                 160 


Pro Gly His Leu Val Arg His Gln Arg Thr His Thr Gly Lys Lys Thr 
                165                 170                 175     


Ser Ser Pro Lys Lys Lys Arg Lys Val Ser Gly Ser Gly Asp Ala Leu 
            180                 185                 190         


Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe 
        195                 200                 205             


Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp 
    210                 215                 220                 


Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Ser 
225                 230                 235                 240 


Ser Gly Ser Pro Lys Lys Lys Arg Lys Val Gly Ser Gln Tyr Leu Pro 
                245                 250                 255     


Asp Thr Asp Asp Arg His Arg Ile Glu Glu Lys Arg Lys Arg Thr Tyr 
            260                 265                 270         


Glu Thr Phe Lys Ser Ile Met Lys Lys Ser Pro Phe Ser Gly Pro Thr 
        275                 280                 285             


Asp Pro Arg Pro Pro Pro Arg Arg Ile Ala Val Pro Ser Arg Ser Ser 
    290                 295                 300                 


Ala Ser Val Pro Lys Pro Ala Pro Gln Pro Tyr Pro Phe Thr Ser Ser 
305                 310                 315                 320 


Leu Ser Thr Ile Asn Tyr Asp Glu Phe Pro Thr Met Val Phe Pro Ser 
                325                 330                 335     


Gly Gln Ile Ser Gln Ala Ser Ala Leu Ala Pro Ala Pro Pro Gln Val 
            340                 345                 350         


Leu Pro Gln Ala Pro Ala Pro Ala Pro Ala Pro Ala Met Val Ser Ala 
        355                 360                 365             


Leu Ala Gln Ala Pro Ala Pro Val Pro Val Leu Ala Pro Gly Pro Pro 
    370                 375                 380                 


Gln Ala Val Ala Pro Pro Ala Pro Lys Pro Thr Gln Ala Gly Glu Gly 
385                 390                 395                 400 


Thr Leu Ser Glu Ala Leu Leu Gln Leu Gln Phe Asp Asp Glu Asp Leu 
                405                 410                 415     


Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro Ala Val Phe Thr Asp Leu 
            420                 425                 430         


Ala Ser Val Asp Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly Ile 
        435                 440                 445             


Pro Val Ala Pro His Thr Thr Glu Pro Met Leu Met Glu Tyr Pro Glu 
    450                 455                 460                 


Ala Ile Thr Arg Leu Val Thr Gly Ala Gln Arg Pro Pro Asp Pro Ala 
465                 470                 475                 480 


Pro Ala Pro Leu Gly Ala Pro Gly Leu Pro Asn Gly Leu Leu Ser Gly 
                485                 490                 495     


Asp Glu Asp Phe Ser Ser Ile Ala Asp Met Asp Phe Ser Ala Leu Leu 
            500                 505                 510         


Gly Ser Gly Ser Gly Ser Arg Asp Ser Arg Glu Gly Met Phe Leu Pro 
        515                 520                 525             


Lys Pro Glu Ala Gly Ser Ala Ile Ser Asp Val Phe Glu Gly Arg Glu 
    530                 535                 540                 


Val Cys Gln Pro Lys Arg Ile Arg Pro Phe His Pro Pro Gly Ser Pro 
545                 550                 555                 560 


Trp Ala Asn Arg Pro Leu Pro Ala Ser Leu Ala Pro Thr Pro Thr Gly 
                565                 570                 575     


Pro Val His Glu Pro Val Gly Ser Leu Thr Pro Ala Pro Val Pro Gln 
            580                 585                 590         


Pro Leu Asp Pro Ala Pro Ala Val Thr Pro Glu Ala Ser His Leu Leu 
        595                 600                 605             


Glu Asp Pro Asp Glu Glu Thr Ser Gln Ala Val Lys Ala Leu Arg Glu 
    610                 615                 620                 


Met Ala Asp Thr Val Ile Pro Gln Lys Glu Glu Ala Ala Ile Cys Gly 
625                 630                 635                 640 


Gln Met Asp Leu Ser His Pro Pro Pro Arg Gly His Leu Asp Glu Leu 
                645                 650                 655     


Thr Thr Thr Leu Glu Ser Met Thr Glu Asp Leu Asn Leu Asp Ser Pro 
            660                 665                 670         


Leu Thr Pro Glu Leu Asn Glu Ile Leu Asp Thr Phe Leu Asn Asp Glu 
        675                 680                 685             


Cys Leu Leu His Ala Met His Ile Ser Thr Gly Leu Ser Ile Phe Asp 
    690                 695                 700                 


Thr Ser Leu Phe 
705             


<210>  7
<211>  677
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  7

Leu Glu Pro Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser 
1               5                   10                  15      


Phe Ser Ser Lys Lys Ala Leu Thr Glu His Gln Arg Thr His Thr Gly 
            20                  25                  30          


Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Arg Ala 
        35                  40                  45              


Asp Asn Leu Thr Glu His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr 
    50                  55                  60                  


Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Arg Ser Asp His Leu Thr 
65                  70                  75                  80  


Asn His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu 
                85                  90                  95      


Cys Gly Lys Ser Phe Ser Asp Lys Lys Asp Leu Thr Arg His Gln Arg 
            100                 105                 110         


Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser 
        115                 120                 125             


Phe Ser Arg Ser Asp Lys Leu Thr Glu His Gln Arg Thr His Thr Gly 
    130                 135                 140                 


Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Asp Pro 
145                 150                 155                 160 


Gly His Leu Val Arg His Gln Arg Thr His Thr Gly Lys Lys Thr Ser 
                165                 170                 175     


Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala 
            180                 185                 190         


Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp 
        195                 200                 205             


Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu 
    210                 215                 220                 


Asp Met Leu Gln Tyr Leu Pro Asp Thr Asp Asp Arg His Arg Ile Glu 
225                 230                 235                 240 


Glu Lys Arg Lys Arg Thr Tyr Glu Thr Phe Lys Ser Ile Met Lys Lys 
                245                 250                 255     


Ser Pro Phe Ser Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg Arg Ile 
            260                 265                 270         


Ala Val Pro Ser Arg Ser Ser Ala Ser Val Pro Lys Pro Ala Pro Gln 
        275                 280                 285             


Pro Tyr Pro Phe Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp Glu Phe 
    290                 295                 300                 


Pro Thr Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser Ala Leu 
305                 310                 315                 320 


Ala Pro Ala Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro Ala Pro 
                325                 330                 335     


Ala Pro Ala Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro Val Pro 
            340                 345                 350         


Val Leu Ala Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala Pro Lys 
        355                 360                 365             


Pro Thr Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu Gln Leu 
    370                 375                 380                 


Gln Phe Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp 
385                 390                 395                 400 


Pro Ala Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu Phe Gln 
                405                 410                 415     


Gln Leu Leu Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr Glu Pro 
            420                 425                 430         


Met Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr Gly Ala 
        435                 440                 445             


Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro Gly Leu 
    450                 455                 460                 


Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe Ser Ser Ile Ala Asp 
465                 470                 475                 480 


Met Asp Phe Ser Ala Leu Leu Arg Asp Ser Arg Glu Gly Met Phe Leu 
                485                 490                 495     


Pro Lys Pro Glu Ala Gly Ser Ala Ile Ser Asp Val Phe Glu Gly Arg 
            500                 505                 510         


Glu Val Cys Gln Pro Lys Arg Ile Arg Pro Phe His Pro Pro Gly Ser 
        515                 520                 525             


Pro Trp Ala Asn Arg Pro Leu Pro Ala Ser Leu Ala Pro Thr Pro Thr 
    530                 535                 540                 


Gly Pro Val His Glu Pro Val Gly Ser Leu Thr Pro Ala Pro Val Pro 
545                 550                 555                 560 


Gln Pro Leu Asp Pro Ala Pro Ala Val Thr Pro Glu Ala Ser His Leu 
                565                 570                 575     


Leu Glu Asp Pro Asp Glu Glu Thr Ser Gln Ala Val Lys Ala Leu Arg 
            580                 585                 590         


Glu Met Ala Asp Thr Val Ile Pro Gln Lys Glu Glu Ala Ala Ile Cys 
        595                 600                 605             


Gly Gln Met Asp Leu Ser His Pro Pro Pro Arg Gly His Leu Asp Glu 
    610                 615                 620                 


Leu Thr Thr Thr Leu Glu Ser Met Thr Glu Asp Leu Asn Leu Asp Ser 
625                 630                 635                 640 


Pro Leu Thr Pro Glu Leu Asn Glu Ile Leu Asp Thr Phe Leu Asn Asp 
                645                 650                 655     


Glu Cys Leu Leu His Ala Met His Ile Ser Thr Gly Leu Ser Ile Phe 
            660                 665                 670         


Asp Thr Ser Leu Phe 
        675         


<210>  8
<211>  177
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  8

Leu Glu Pro Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser 
1               5                   10                  15      


Phe Ser Ser Lys Lys Ala Leu Thr Glu His Gln Arg Thr His Thr Gly 
            20                  25                  30          


Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Arg Ala 
        35                  40                  45              


Asp Asn Leu Thr Glu His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr 
    50                  55                  60                  


Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Arg Ser Asp His Leu Thr 
65                  70                  75                  80  


Asn His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu 
                85                  90                  95      


Cys Gly Lys Ser Phe Ser Asp Lys Lys Asp Leu Thr Arg His Gln Arg 
            100                 105                 110         


Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser 
        115                 120                 125             


Phe Ser Arg Ser Asp Lys Leu Thr Glu His Gln Arg Thr His Thr Gly 
    130                 135                 140                 


Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Asp Pro 
145                 150                 155                 160 


Gly His Leu Val Arg His Gln Arg Thr His Thr Gly Lys Lys Thr Ser 
                165                 170                 175     


Ser 
    


<210>  9
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  9

Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu 
1               5                   10                  15      


Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe 
            20                  25                  30          


Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp 
        35                  40                  45              


Met Leu 
    50  


<210>  10
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  10

Gln Tyr Leu Pro Asp Thr Asp Asp Arg His Arg Ile Glu Glu Lys Arg 
1               5                   10                  15      


Lys Arg Thr Tyr Glu Thr Phe Lys Ser Ile Met Lys Lys Ser Pro Phe 
            20                  25                  30          


Ser Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg Arg Ile Ala Val Pro 
        35                  40                  45              


Ser Arg Ser Ser Ala Ser Val Pro Lys Pro Ala Pro Gln Pro Tyr Pro 
    50                  55                  60                  


Phe Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp Glu Phe Pro Thr Met 
65                  70                  75                  80  


Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser Ala Leu Ala Pro Ala 
                85                  90                  95      


Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro Ala Pro Ala Pro Ala 
            100                 105                 110         


Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro Val Pro Val Leu Ala 
        115                 120                 125             


Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala Pro Lys Pro Thr Gln 
    130                 135                 140                 


Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu Gln Leu Gln Phe Asp 
145                 150                 155                 160 


Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro Ala Val 
                165                 170                 175     


Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln Leu Leu 
            180                 185                 190         


Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr Glu Pro Met Leu Met 
        195                 200                 205             


Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr Gly Ala Gln Arg Pro 
    210                 215                 220                 


Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro Gly Leu Pro Asn Gly 
225                 230                 235                 240 


Leu Leu Ser Gly Asp Glu Asp Phe Ser Ser Ile Ala Asp Met Asp Phe 
                245                 250                 255     


Ser Ala Leu Leu 
            260 


<210>  11
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  11

Arg Asp Ser Arg Glu Gly Met Phe Leu Pro Lys Pro Glu Ala Gly Ser 
1               5                   10                  15      


Ala Ile Ser Asp Val Phe Glu Gly Arg Glu Val Cys Gln Pro Lys Arg 
            20                  25                  30          


Ile Arg Pro Phe His Pro Pro Gly Ser Pro Trp Ala Asn Arg Pro Leu 
        35                  40                  45              


Pro Ala Ser Leu Ala Pro Thr Pro Thr Gly Pro Val His Glu Pro Val 
    50                  55                  60                  


Gly Ser Leu Thr Pro Ala Pro Val Pro Gln Pro Leu Asp Pro Ala Pro 
65                  70                  75                  80  


Ala Val Thr Pro Glu Ala Ser His Leu Leu Glu Asp Pro Asp Glu Glu 
                85                  90                  95      


Thr Ser Gln Ala Val Lys Ala Leu Arg Glu Met Ala Asp Thr Val Ile 
            100                 105                 110         


Pro Gln Lys Glu Glu Ala Ala Ile Cys Gly Gln Met Asp Leu Ser His 
        115                 120                 125             


Pro Pro Pro Arg Gly His Leu Asp Glu Leu Thr Thr Thr Leu Glu Ser 
    130                 135                 140                 


Met Thr Glu Asp Leu Asn Leu Asp Ser Pro Leu Thr Pro Glu Leu Asn 
145                 150                 155                 160 


Glu Ile Leu Asp Thr Phe Leu Asn Asp Glu Cys Leu Leu His Ala Met 
                165                 170                 175     


His Ile Ser Thr Gly Leu Ser Ile Phe Asp Thr Ser Leu Phe 
            180                 185                 190 


<210>  12
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  12

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  13

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  14

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10  


<210>  15
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  15

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Val Asp Leu 
1               5                   10              


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  16

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu 
1               5                   10      


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  17

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  18
<211>  382
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  18

Met Gly Asp Trp Ser Ala Leu Gly Lys Leu Leu Asp Lys Val Gln Ala 
1               5                   10                  15      


Tyr Ser Thr Ala Gly Gly Lys Val Trp Leu Ser Val Leu Phe Ile Phe 
            20                  25                  30          


Arg Ile Leu Leu Leu Gly Thr Ala Val Glu Ser Ala Trp Gly Asp Glu 
        35                  40                  45              


Gln Ser Ala Phe Arg Cys Asn Thr Gln Gln Pro Gly Cys Glu Asn Val 
    50                  55                  60                  


Cys Tyr Asp Lys Ser Phe Pro Ile Ser His Val Arg Phe Trp Val Leu 
65                  70                  75                  80  


Gln Ile Ile Phe Val Ser Val Pro Thr Leu Leu Tyr Leu Ala His Val 
                85                  90                  95      


Phe Tyr Val Met Arg Lys Glu Glu Lys Leu Asn Lys Lys Glu Glu Glu 
            100                 105                 110         


Leu Lys Val Ala Gln Thr Asp Gly Val Asn Val Asp Met His Leu Lys 
        115                 120                 125             


Gln Ile Glu Ile Lys Lys Phe Lys Tyr Gly Ile Glu Glu His Gly Lys 
    130                 135                 140                 


Val Lys Met Arg Gly Gly Leu Leu Arg Thr Tyr Ile Ile Ser Ile Leu 
145                 150                 155                 160 


Phe Lys Ser Ile Phe Glu Val Ala Phe Leu Leu Ile Gln Trp Tyr Ile 
                165                 170                 175     


Tyr Gly Phe Ser Leu Ser Ala Val Tyr Thr Cys Lys Arg Asp Pro Cys 
            180                 185                 190         


Pro His Gln Val Asp Cys Phe Leu Ser Arg Pro Thr Glu Lys Thr Ile 
        195                 200                 205             


Phe Ile Ile Phe Met Leu Val Val Ser Leu Val Ser Leu Ala Leu Asn 
    210                 215                 220                 


Ile Ile Glu Leu Phe Tyr Val Phe Phe Lys Gly Val Lys Asp Arg Val 
225                 230                 235                 240 


Lys Gly Lys Ser Asp Pro Tyr His Ala Thr Ser Gly Ala Leu Ser Pro 
                245                 250                 255     


Ala Lys Asp Cys Gly Ser Gln Lys Tyr Ala Tyr Phe Asn Gly Cys Ser 
            260                 265                 270         


Ser Pro Thr Ala Pro Leu Ser Pro Met Ser Pro Pro Gly Tyr Lys Leu 
        275                 280                 285             


Val Thr Gly Asp Arg Asn Asn Ser Ser Cys Arg Asn Tyr Asn Lys Gln 
    290                 295                 300                 


Ala Ser Glu Gln Asn Trp Ala Asn Tyr Ser Ala Glu Gln Asn Arg Met 
305                 310                 315                 320 


Gly Gln Ala Gly Ser Thr Ile Ser Asn Ser His Ala Gln Pro Phe Asp 
                325                 330                 335     


Phe Pro Asp Asp Asn Gln Asn Ser Lys Lys Leu Ala Ala Gly His Glu 
            340                 345                 350         


Leu Gln Pro Leu Ala Ile Val Asp Gln Arg Pro Ser Ser Arg Ala Ser 
        355                 360                 365             


Ser Arg Ala Ser Ser Arg Pro Arg Pro Asp Asp Leu Glu Ile 
    370                 375                 380         


<210>  19
<211>  382
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  19

Met Gly Asp Trp Ser Ala Leu Gly Lys Leu Leu Asp Lys Val Gln Ala 
1               5                   10                  15      


Tyr Ser Thr Ala Gly Gly Lys Val Trp Leu Ser Val Leu Phe Ile Phe 
            20                  25                  30          


Arg Ile Leu Leu Leu Gly Thr Ala Val Glu Ser Ala Trp Gly Asp Glu 
        35                  40                  45              


Gln Ser Ala Phe Arg Cys Asn Thr Gln Gln Pro Gly Cys Glu Asn Val 
    50                  55                  60                  


Cys Tyr Asp Lys Ser Phe Pro Ile Ser His Val Arg Phe Trp Val Leu 
65                  70                  75                  80  


Gln Ile Ile Phe Val Ser Val Pro Thr Leu Leu Tyr Leu Ala His Val 
                85                  90                  95      


Phe Tyr Val Met Arg Lys Glu Glu Lys Leu Asn Lys Lys Glu Glu Glu 
            100                 105                 110         


Leu Lys Val Ala Gln Thr Asp Gly Val Asn Val Asp Met His Leu Lys 
        115                 120                 125             


Gln Ile Glu Ile Lys Lys Phe Lys Tyr Gly Ile Glu Glu His Gly Lys 
    130                 135                 140                 


Val Lys Met Arg Gly Gly Leu Leu Arg Thr Tyr Ile Ile Ser Ile Leu 
145                 150                 155                 160 


Phe Lys Ser Ile Phe Glu Val Ala Phe Leu Leu Ile Gln Trp Tyr Ile 
                165                 170                 175     


Tyr Gly Phe Ser Leu Ser Ala Val Tyr Thr Cys Lys Arg Asp Pro Cys 
            180                 185                 190         


Pro His Gln Val Asp Cys Phe Leu Ser Arg Pro Thr Glu Lys Thr Ile 
        195                 200                 205             


Phe Ile Ile Phe Met Leu Val Val Ser Leu Val Ser Leu Ala Leu Asn 
    210                 215                 220                 


Ile Ile Glu Leu Phe Tyr Val Phe Phe Lys Gly Val Lys Asp Arg Val 
225                 230                 235                 240 


Lys Gly Lys Ser Asp Pro Tyr His Ala Thr Ser Gly Ala Leu Ser Pro 
                245                 250                 255     


Ala Lys Asp Cys Gly Ser Gln Lys Tyr Ala Tyr Phe Asn Gly Cys Ser 
            260                 265                 270         


Ser Pro Thr Ala Pro Leu Ser Pro Met Ser Pro Pro Gly Tyr Lys Leu 
        275                 280                 285             


Val Thr Gly Asp Arg Asn Asn Ser Ser Cys Arg Asn Tyr Asn Lys Gln 
    290                 295                 300                 


Ala Ser Glu Gln Asn Trp Ala Asn Tyr Ser Ala Glu Gln Asn Arg Met 
305                 310                 315                 320 


Gly Gln Ala Gly Ser Thr Ile Ser Asn Ser His Ala Gln Pro Phe Asp 
                325                 330                 335     


Phe Pro Asp Asp Asn Gln Asn Ser Lys Lys Leu Ala Ala Gly His Glu 
            340                 345                 350         


Leu Gln Pro Leu Ala Ile Val Asp Gln Arg Pro Ser Ser Arg Ala Ala 
        355                 360                 365             


Ser Arg Ala Ser Ser Arg Pro Arg Pro Asp Asp Leu Glu Ile 
    370                 375                 380         


<210>  20
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  20

Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Ile 
1               5                   10                  15      


Asn Ser Arg Ser Ser Gly Ser Pro Lys Lys Lys Arg Lys Val Gly Ser 
            20                  25                  30          


Gln Tyr Leu Pro Asp Thr Asp Asp Arg His Arg Ile Glu Glu Lys Arg 
        35                  40                  45              


Lys Arg Thr Tyr Glu Thr Phe Lys Ser Ile Met Lys Lys Ser Pro Phe 
    50                  55                  60                  


Ser Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg Arg Ile Ala Val Pro 
65                  70                  75                  80  


Ser Arg Ser Ser Ala Ser Val Pro Lys Pro Ala Pro Gln Pro Tyr Pro 
                85                  90                  95      


Phe Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp Glu Phe Pro Thr Met 
            100                 105                 110         


Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser Ala Leu Ala Pro Ala 
        115                 120                 125             


Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro Ala Pro Ala Pro Ala 
    130                 135                 140                 


Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro Val Pro Val Leu Ala 
145                 150                 155                 160 


Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala Pro Lys Pro Thr Gln 
                165                 170                 175     


Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu Gln Leu Gln Phe Asp 
            180                 185                 190         


Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro Ala Val 
        195                 200                 205             


Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln Leu Leu 
    210                 215                 220                 


Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr Glu Pro Met Leu Met 
225                 230                 235                 240 


Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr Gly Ala Gln Arg Pro 
                245                 250                 255     


Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro Gly Leu Pro Asn Gly 
            260                 265                 270         


Leu Leu Ser Gly Asp Glu Asp Phe Ser Ser Ile Ala Asp Met Asp Phe 
        275                 280                 285             


Ser Ala Leu Leu Gly Ser Gly Ser Gly Ser Arg Asp Ser Arg Glu Gly 
    290                 295                 300                 


Met Phe Leu Pro Lys Pro Glu Ala Gly Ser Ala Ile Ser Asp Val Phe 
305                 310                 315                 320 


Glu Gly Arg Glu Val Cys Gln Pro Lys Arg Ile Arg Pro Phe His Pro 
                325                 330                 335     


Pro Gly Ser Pro Trp Ala Asn Arg Pro Leu Pro Ala Ser Leu Ala Pro 
            340                 345                 350         


Thr Pro Thr Gly Pro Val His Glu Pro Val Gly Ser Leu Thr Pro Ala 
        355                 360                 365             


Pro Val Pro Gln Pro Leu Asp Pro Ala Pro Ala Val Thr Pro Glu Ala 
    370                 375                 380                 


Ser His Leu Leu Glu Asp Pro Asp Glu Glu Thr Ser Gln Ala Val Lys 
385                 390                 395                 400 


Ala Leu Arg Glu Met Ala Asp Thr Val Ile Pro Gln Lys Glu Glu Ala 
                405                 410                 415     


Ala Ile Cys Gly Gln Met Asp Leu Ser His Pro Pro Pro Arg Gly His 
            420                 425                 430         


Leu Asp Glu Leu Thr Thr Thr Leu Glu Ser Met Thr Glu Asp Leu Asn 
        435                 440                 445             


Leu Asp Ser Pro Leu Thr Pro Glu Leu Asn Glu Ile Leu Asp Thr Phe 
    450                 455                 460                 


Leu Asn Asp Glu Cys Leu Leu His Ala Met His Ile Ser Thr Gly Leu 
465                 470                 475                 480 


Ser Ile Phe Asp Thr Ser Leu Phe 
                485             


<210>  21
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  21
ctcatgggat gtgattcttt cgacc                                             25


<210>  22
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  22
tttctgtcca ggagacagga gcat                                              24


<210>  23
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  23
caccaactgg gacgacat                                                     18


<210>  24
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  24
acagcctgga tagcaacg                                                     18


<210>  25
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  25
ggactataag gacgacgatg acaaga                                            26


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  26
gtatgggtcc tctgatggcg                                                   20


<210>  27
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  27
tgtcccgaat gcggca                                                       16


<210>  28
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  28
agggcgtcac tgccg                                                        15


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  29
ctgggtctgg cggaccctga                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  30
tcgcgcgcgc tccttccagg                                                   20


<210>  31
<211>  2298
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  31
atggactata aggacgacga tgacaagaag aggccagcgg ctactaaaaa ggctggacag       60

gccaaaaaga aaaaactgga gcccggcgaa aagccgtata agtgcccaga atgtgggaag      120

agtttttcta gtaagaaagc attgacggag caccagagaa cacacacagg tgaaaagcct      180

tacaaatgcc ctgaatgcgg taaaagcttc agtcgagcgg ataatctcac ggagcatcaa      240

cggacacaca ctggtgaaaa accttataaa tgtcccgaat gcggcaaatc tttcagtaga      300

agtgatcatc ttactaacca ccagcgcacc cacacaggcg agaaaccgta taaatgcccc      360

gagtgtggta agtccttttc cgataaaaaa gatcttactc gccaccaacg cacccacacg      420

ggagaaaaac catataagtg tcctgagtgt ggcaaatctt tttctaggag tgataaactt      480

acggaacacc agaggactca tactggagag aagccatata aatgtccgga atgcgggaaa      540

agtttttcag atccaggtca cttggtgcgc catcagagga cccatacggg aaaaaagacg      600

agcagcgctg ctgaccccaa gaagaagagg aaggtgtcgc cagggatccg tcgacttgac      660

gcgttgatat caacaagttt gtacaaaaaa gcaggctaca aagaggccag cggttccgga      720

cgggctgacg cattggacga ttttgatctg gatatgctgg gaagtgacgc cctcgatgat      780

tttgaccttg acatgcttgg ttcggatgcc cttgatgact ttgacctcga catgctcggc      840

agtgacgccc ttgatgattt cgacctggac atgctgatta actctagaag ttccggatct      900

ccgaaaaaga aacgcaaagt tggtagccag tacctgcccg acaccgacga ccggcaccgg      960

atcgaggaaa agcggaagcg gacctacgag acattcaaga gcatcatgaa gaagtccccc     1020

ttcagcggcc ccaccgaccc tagacctcca cctagaagaa tcgccgtgcc cagcagatcc     1080

agcgccagcg tgccaaaacc tgccccccag ccttacccct tcaccagcag cctgagcacc     1140

atcaactacg acgagttccc taccatggtg ttccccagcg gccagatctc tcaggcctct     1200

gctctggctc cagcccctcc tcaggtgctg cctcaggctc ctgctcctgc accagctcca     1260

gccatggtgt ctgcactggc tcaggcacca gcacccgtgc ctgtgctggc tcctggacct     1320

ccacaggctg tggctccacc agcccctaaa cctacacagg ccggcgaggg cacactgtct     1380

gaagctctgc tgcagctgca gttcgacgac gaggatctgg gagccctgct gggaaacagc     1440

accgatcctg ccgtgttcac cgacctggcc agcgtggaca acagcgagtt ccagcagctg     1500

ctgaaccagg gcatccctgt ggcccctcac accaccgagc ccatgctgat ggaatacccc     1560

gaggccatca cccggctcgt gacaggcgct cagaggcctc ctgatccagc tcctgcccct     1620

ctgggagcac caggcctgcc taatggactg ctgtctggcg acgaggactt cagctctatc     1680

gccgatatgg atttctcagc cttgctgggc tctggcagcg gcagccggga ttccagggaa     1740

gggatgtttt tgccgaagcc tgaggccggc tccgctatta gtgacgtgtt tgagggccgc     1800

gaggtgtgcc agccaaaacg aatccggcca tttcatcctc caggaagtcc atgggccaac     1860

cgcccactcc ccgccagcct cgcaccaaca ccaaccggtc cagtacatga gccagtcggg     1920

tcactgaccc cggcaccagt ccctcagcca ctggatccag cgcccgcagt gactcccgag     1980

gccagtcacc tgttggagga tcccgatgaa gagacgagcc aggctgtcaa agcccttcgg     2040

gagatggccg atactgtgat tccccagaag gaagaggctg caatctgtgg ccaaatggac     2100

ctttcccatc cgcccccaag gggccatctg gatgagctga caaccacact tgagtccatg     2160

accgaggatc tgaacctgga ctcacccctg accccggaat tgaacgagat tctggatacc     2220

ttcctgaacg acgagtgcct cttgcatgcc atgcatatca gcacaggact gtccatcttc     2280

gacacatctc tgttttga                                                   2298


<210>  32
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  32

Leu Glu Pro Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser 
1               5                   10                  15      


Phe Ser Asp Pro Gly His Leu Val Arg His Gln Arg Thr His Thr Gly 
            20                  25                  30          


Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Arg Asn 
        35                  40                  45              


Asp Ala Leu Thr Glu His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr 
    50                  55                  60                  


Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Arg Ser Asp Glu Leu Val 
65                  70                  75                  80  


Arg His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu 
                85                  90                  95      


Cys Gly Lys Ser Phe Ser Arg Asn Asp Ala Leu Thr Glu His Gln Arg 
            100                 105                 110         


Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser 
        115                 120                 125             


Phe Ser Asp Pro Gly His Leu Val Arg His Gln Arg Thr His Thr Gly 
    130                 135                 140                 


Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Arg Arg 
145                 150                 155                 160 


Asp Glu Leu Asn Val His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr 
                165                 170                 175     


Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Arg Ser Asp Lys Leu Val 
            180                 185                 190         


Arg His Gln Arg Thr His Thr Gly Lys Lys Thr Ser 
        195                 200                 


<210>  33
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  33

Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly 
1               5                   10                  15      


Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala 
            20                  25                  30          


Leu Asp Asp Phe Asp Leu Asp Met Leu Ile Asn Ser Arg Ser Ser Gly 
        35                  40                  45              


Ser Pro Lys Lys Lys Arg Lys Val Gly Ser Gln Tyr Leu Pro Asp Thr 
    50                  55                  60                  


Asp Asp Arg His Arg Ile Glu Glu Lys Arg Lys Arg Thr Tyr Glu Thr 
65                  70                  75                  80  


Phe Lys Ser Ile Met Lys Lys Ser Pro Phe Ser Gly Pro Thr Asp Pro 
                85                  90                  95      


Arg Pro Pro Pro Arg Arg Ile Ala Val Pro Ser Arg Ser Ser Ala Ser 
            100                 105                 110         


Val Pro Lys Pro Ala Pro Gln Pro Tyr Pro Phe Thr Ser Ser Leu Ser 
        115                 120                 125             


Thr Ile Asn Tyr Asp Glu Phe Pro Thr Met Val Phe Pro Ser Gly Gln 
    130                 135                 140                 


Ile Ser Gln Ala Ser Ala Leu Ala Pro Ala Pro Pro Gln Val Leu Pro 
145                 150                 155                 160 


Gln Ala Pro Ala Pro Ala Pro Ala Pro Ala Met Val Ser Ala Leu Ala 
                165                 170                 175     


Gln Ala Pro Ala Pro Val Pro Val Leu Ala Pro Gly Pro Pro Gln Ala 
            180                 185                 190         


Val Ala Pro Pro Ala Pro Lys Pro Thr Gln Ala Gly Glu Gly Thr Leu 
        195                 200                 205             


Ser Glu Ala Leu Leu Gln Leu Gln Phe Asp Asp Glu Asp Leu Gly Ala 
    210                 215                 220                 


Leu Leu Gly Asn Ser Thr Asp Pro Ala Val Phe Thr Asp Leu Ala Ser 
225                 230                 235                 240 


Val Asp Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly Ile Pro Val 
                245                 250                 255     


Ala Pro His Thr Thr Glu Pro Met Leu Met Glu Tyr Pro Glu Ala Ile 
            260                 265                 270         


Thr Arg Leu Val Thr Gly Ala Gln Arg Pro Pro Asp Pro Ala Pro Ala 
        275                 280                 285             


Pro Leu Gly Ala Pro Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp Glu 
    290                 295                 300                 


Asp Phe Ser Ser Ile Ala Asp Met Asp Phe Ser Ala Leu Leu Gly Ser 
305                 310                 315                 320 


Gly Ser Gly Ser Arg Asp Ser Arg Glu Gly Met Phe Leu Pro Lys Pro 
                325                 330                 335     


Glu Ala Gly Ser Ala Ile Ser Asp Val Phe Glu Gly Arg Glu Val Cys 
            340                 345                 350         


Gln Pro Lys Arg Ile Arg Pro Phe His Pro Pro Gly Ser Pro Trp Ala 
        355                 360                 365             


Asn Arg Pro Leu Pro Ala Ser Leu Ala Pro Thr Pro Thr Gly Pro Val 
    370                 375                 380                 


His Glu Pro Val Gly Ser Leu Thr Pro Ala Pro Val Pro Gln Pro Leu 
385                 390                 395                 400 


Asp Pro Ala Pro Ala Val Thr Pro Glu Ala Ser His Leu Leu Glu Asp 
                405                 410                 415     


Pro Asp Glu Glu Thr Ser Gln Ala Val Lys Ala Leu Arg Glu Met Ala 
            420                 425                 430         


Asp Thr Val Ile Pro Gln Lys Glu Glu Ala Ala Ile Cys Gly Gln Met 
        435                 440                 445             


Asp Leu Ser His Pro Pro Pro Arg Gly His Leu Asp Glu Leu Thr Thr 
    450                 455                 460                 


Thr Leu Glu Ser Met Thr Glu Asp Leu Asn Leu Asp Ser Pro Leu Thr 
465                 470                 475                 480 


Pro Glu Leu Asn Glu Ile Leu Asp Thr Phe Leu Asn Asp Glu Cys Leu 
                485                 490                 495     


Leu His Ala Met His Ile Ser Thr Gly Leu Ser Ile Phe Asp Thr Ser 
            500                 505                 510         


Leu Phe 
        


