                         SEQUENCE LISTING

<110>  PRESIDENT AND FELLOWS OF HARVARD COLLEGE
 
<120>  SCG2 NEUROPEPTIDES AND USES THEREOF

<130>  002806-099210WOPT

<150>  63/122,156
<151>  2020-12-07

<160>  68    

<170>  PatentIn version 3.5

<210>  1
<211>  5422
<212>  DNA
<213>  Homo sapiens

<400>  1
gaaacggccc gagaagctcg cccggagaac ggggaggaat atgctgtgga gctcctctgc       60

catataaaca aaaagaggta aggctgcttt tctctttgat ttattggaaa gttccaaatt      120

gcatgctctt cttttaattc ctagctgaga agaaaaagac tgtttggcaa gcttatgtcg      180

ataggataac tgaatagcaa cctgctgctc atcagccaat gtaaggacac tacatatgtg      240

tatatacatg atcgggtcta tgctttatac tacttgatgt tggatattta ctaaccagaa      300

tgttacttag ataatcatat aaaaaagagt gaaaaagtta aggattttag tgtcaataca      360

cagattaatg taaagttaac caagcccaat atcttgtttc tttccaaaat ttattatttc      420

tgccactaag agccagatac gaagccaggg gtataattta tatgtttaat attcttaaca      480

gtaggtttcc aatgatacaa aggctgtcaa gcatgttagt cataaaggca acccattttg      540

gaactaggtt ttttttcttt gatatttatc ttacaagagc tctgaattaa ctaaccacat      600

aaaattcttt tctgaacttg tatatttgaa agagcttaca ttattatctc ctaattttag      660

ttctaagatg ttaacttagg attttcctga acactggatt cttccttttt ccagggcaaa      720

atattatctt gggttgtaat ttggctgtga ccatgaatta cagagaaatg atcattttga      780

atacatgatg aaaatactca taactttgta aattgttatt gttattgcta taatttgatt      840

taaagaggat gttcaatatg ttgctaaaga ttttgtctgg gacaagtatt tcattttttc      900

tgtatcccaa ctagttgaat tgcttaaatt acatatagtc acctgcatgt gtcaatgctc      960

tagcctgaat tcaacagaaa agacatttta acttgagaga ttttaatgat agctatcagg     1020

ggaaaaataa tgttctaatt atttggattt cagaaaattc aattttaaat caaaccccat     1080

atagaatagt agagctgttg aaacatcttt actacttgaa agagctgcta cctgggaaaa     1140

gaatcctttg ggtctcactc aaaggcaata actatgtcat tcaaactgaa gctgaatagt     1200

taagcaaagg gtagcacttc ttaggctgtg gtttaaacaa ctgcaatgag tagtctgctt     1260

caactttaca gcaaagtgca gttccaagat aatgatttta aagatgagca tataatccac     1320

atgttaagac tatttcagta ttgtggcttc aaaaaaaata agttcagtaa ggtttttaag     1380

attattattt caaatgccaa tgttgaaagt tgattaccaa agctacatta atcctgaaat     1440

aatataaaca agagtgcata atgtattttt atttgaacct cattatttta tgaataaaat     1500

tacttatagt aaacatgtat ttataataaa tattttggaa gtatcctctc aaatgccttt     1560

caagatgttt ctttcaataa attaagtact ctggtaaacg tgaatcattt aaataggtat     1620

atacgtatgc taaaatgttt tcataactaa gccattattg ggctctaaaa aactggaaac     1680

aaaatcatca atatgatctt gtgaacaatg gtattttcta caattgatgt ctaagctaac     1740

agaaaattgt atacatataa cttagcttat ctatcacaaa accatgatct ggtaaagata     1800

tgaacaaact tgtaaactcc tcttacattc attttgttta caacaaaata gccaatatta     1860

aaatagtttt ttcaatgtta gcaatattaa atgtaaaaca cataaaaact aatcctcttc     1920

ctaattccta tgtaagattt taaggcatcg gaggaaataa tgaatggaga tttttaagta     1980

ggaagaattc agcacatcat ctgtgtttat ttgaattggg atttacatag tggttatttt     2040

aagatttttc taaacagtat gagtgattta agatttcaca ggtccatacc aaaatagaca     2100

cagacagaag acaaactgaa tctgaacact cacaagttca gaaatagact agctaaaaaa     2160

acttatgttc tctctgtagc atctgttatt atttactata cactctgaag ggctgatgaa     2220

aagtataacc acaattgcat tttgcaagac agtcataata taaattatta gaagaaatat     2280

gaagcaaaga gattttaaaa cactttattg gtttagcacg ttcacacaaa aagaaacttc     2340

attggtttag tctactggct ggaatctgag aagacccgtg ttctggaggt tatttatgga     2400

tcattggatt cggtatcaga ttgagaacaa gttatttctg aaaaatatat ctggatagga     2460

ctccccagaa ggtaattcgg tatgattgac atataaaagt attactttgt catatatggt     2520

catgtaactg cagctgtgtt tcagcaacaa aattagatgg acatttcagg aaataaacca     2580

catgtttttt gacacaactt taaggacata atttgtgggc gcgtatgtgt aaatgcatgt     2640

tttaaattaa gccaacacat tattttgcca atagacttca atatataaaa taattaaaac     2700

atcttgggaa gtatttgctg ctttattata gagaaacaac atgtactaaa catcaaacta     2760

caagttctgt aaatgaaaaa ataaaattta agaaatctca tatcagtgtt tttgctgttg     2820

ttttaactaa gagaatgcta tgcaagtttt tggtgaatga gtaataattt tgctaaagat     2880

tcctgtggtt tgcttgtggg aatcatgtgg aaaatattca tgaattttta aaaagagtta     2940

tcctaagctt aatgtgaaat aatatctact atgttttttc ctcacctcaa tgatcaatta     3000

tttcttttgc tatagtgtct tctagtttgt ttcatttgtg taactcatat tttttatgtt     3060

ttaaggaaat ctttcaaaca tggctgaagc aaagacccac tggcttggag cagccctgtc     3120

tcttatccct ttaattttcc tcatctctgg ggctgaagca gcttcatttc agagaaacca     3180

gctgcttcag aaagaaccag acctcaggtt ggaaaatgtc caaaagtttc ccagtcctga     3240

aatgatcagg gctttggagt acatagaaaa cctccgacaa caagctcata aggaagaaag     3300

cagcccagat tataatccct accaaggtgt ctctgtcccc cttcagcaaa aagaaaatgg     3360

cgatgaaagc cacttgcccg agagggattc actgagtgaa gaagactgga tgagaataat     3420

actcgaagct ttgagacagg ctgaaaatga gcctcagtct gcaccaaaag aaaataagcc     3480

ctatgccttg aattcagaaa agaactttcc aatggacatg agtgatgatt atgagacaca     3540

gcagtggcca gaaagaaagc ttaagcacat gcaattccct cctatgtatg aagagaattc     3600

cagggataac ccctttaaac gcacaaatga aatagtggag gaacaatata ctcctcaaag     3660

ccttgctaca ttggaatctg tcttccaaga gctggggaaa ctgacaggac caaacaacca     3720

gaaacgtgag aggatggatg aggagcaaaa actttatacg gatgatgaag atgatatcta     3780

caaggctaat aacattgcct atgaagatgt ggtcggggga gaagactgga acccagtaga     3840

ggagaaaata gagagtcaaa cccaggaaga ggtgagagac agcaaagaga atatagaaaa     3900

aaatgaacaa atcaacgatg agatgaaacg ctcagggcag cttggcatcc aggaagaaga     3960

tcttcggaaa gagagtaaag accaactctc agatgatgtc tccaaagtaa ttgcctattt     4020

gaaaaggtta gtaaatgctg caggaagtgg gaggttacag aatgggcaaa atggggaaag     4080

ggccaccagg ctttttgaga aacctcttga ttctcagtct atttatcagc tgattgaaat     4140

ctcaaggaat ttacagatac ccccagaaga cttaattgag atgctcaaaa ctggggagaa     4200

gccgaatgga tcagtggaac cggagcggga gcttgacctt cctgttgacc tagatgacat     4260

ctcagaggct gacttagacc atccagacct gttccaaaat aggatgctct ccaagagtgg     4320

ctaccctaaa acacctggtc gtgctgggac tgaggcccta ccagacgggc tcagtgttga     4380

ggatatttta aatcttttag ggatggagag tgcagcaaat cagaaaacgt cgtattttcc     4440

caatccatat aaccaggaga aagttctgcc aaggctccct tatggtgctg gaagatctag     4500

atcgaaccag cttcccaaag ctgcctggat tccacatgtt gaaaacagac agatggcata     4560

tgaaaacctg aacgacaagg atcaagaatt aggtgagtac ttggccagga tgctagttaa     4620

ataccctgag atcattaatt caaaccaagt gaagcgagtt cctggtcaag gctcatctga     4680

agatgacctg caggaagagg aacaaattga gcaggccatc aaagagcatt tgaatcaagg     4740

cagctctcag gagactgaca agctggcccc ggtgagcaaa aggttccctg tggggccccc     4800

gaagaatgat gataccccaa ataggcagta ctgggatgaa gatctgttaa tgaaagtgct     4860

ggaatacctc aaccaagaaa aggcagaaaa gggaagggag catattgcta agagagcaat     4920

ggaaaatatg taagctgctt tcattaatta ccctactttc attcctccca ccccaagcaa     4980

atcccaacat ttctcttcag tgtgttgact tctatcctgt taacactgta atatctttaa     5040

atgatgtaca ggcagatgaa accaggtcac tggggagtct gcttcatttc ctctgagctg     5100

ttatcttgtg tatggatatg tgtaaatgtt atgactcctt gataaaaaat ttattatgtc     5160

cattattcaa gaaagatatc tatgactgtg tttaatagta tatctaatgg ctgtggcatt     5220

gttgatgctc acatatgata aaaaagtgtc ctataattct attgaaagtt tttaatattt     5280

attgaattat tttgttactg tctgtagtgt tttgtggagt actggaccaa aaaaataaag     5340

cattataaat atatagtttt atttataagg ccttttctat tgtgtgtttt actgttgatt     5400

aataaatgtt atttctggac aa                                              5422


<210>  2
<211>  2434
<212>  DNA
<213>  Homo sapiens

<400>  2
gaaacggccc gagaagctcg cccggagaac ggggaggaat atgctgtgga gctcctctgc       60

catataaaca aaaagaggaa atctttcaaa catggctgaa gcaaagaccc actggcttgg      120

agcagccctg tctcttatcc ctttaatttt cctcatctct ggggctgaag cagcttcatt      180

tcagagaaac cagctgcttc agaaagaacc agacctcagg ttggaaaatg tccaaaagtt      240

tcccagtcct gaaatgatca gggctttgga gtacatagaa aacctccgac aacaagctca      300

taaggaagaa agcagcccag attataatcc ctaccaaggt gtctctgtcc cccttcagca      360

aaaagaaaat ggcgatgaaa gccacttgcc cgagagggat tcactgagtg aagaagactg      420

gatgagaata atactcgaag ctttgagaca ggctgaaaat gagcctcagt ctgcaccaaa      480

agaaaataag ccctatgcct tgaattcaga aaagaacttt ccaatggaca tgagtgatga      540

ttatgagaca cagcagtggc cagaaagaaa gcttaagcac atgcaattcc ctcctatgta      600

tgaagagaat tccagggata acccctttaa acgcacaaat gaaatagtgg aggaacaata      660

tactcctcaa agccttgcta cattggaatc tgtcttccaa gagctgggga aactgacagg      720

accaaacaac cagaaacgtg agaggatgga tgaggagcaa aaactttata cggatgatga      780

agatgatatc tacaaggcta ataacattgc ctatgaagat gtggtcgggg gagaagactg      840

gaacccagta gaggagaaaa tagagagtca aacccaggaa gaggtgagag acagcaaaga      900

gaatatagaa aaaaatgaac aaatcaacga tgagatgaaa cgctcagggc agcttggcat      960

ccaggaagaa gatcttcgga aagagagtaa agaccaactc tcagatgatg tctccaaagt     1020

aattgcctat ttgaaaaggt tagtaaatgc tgcaggaagt gggaggttac agaatgggca     1080

aaatggggaa agggccacca ggctttttga gaaacctctt gattctcagt ctatttatca     1140

gctgattgaa atctcaagga atttacagat acccccagaa gacttaattg agatgctcaa     1200

aactggggag aagccgaatg gatcagtgga accggagcgg gagcttgacc ttcctgttga     1260

cctagatgac atctcagagg ctgacttaga ccatccagac ctgttccaaa ataggatgct     1320

ctccaagagt ggctacccta aaacacctgg tcgtgctggg actgaggccc taccagacgg     1380

gctcagtgtt gaggatattt taaatctttt agggatggag agtgcagcaa atcagaaaac     1440

gtcgtatttt cccaatccat ataaccagga gaaagttctg ccaaggctcc cttatggtgc     1500

tggaagatct agatcgaacc agcttcccaa agctgcctgg attccacatg ttgaaaacag     1560

acagatggca tatgaaaacc tgaacgacaa ggatcaagaa ttaggtgagt acttggccag     1620

gatgctagtt aaataccctg agatcattaa ttcaaaccaa gtgaagcgag ttcctggtca     1680

aggctcatct gaagatgacc tgcaggaaga ggaacaaatt gagcaggcca tcaaagagca     1740

tttgaatcaa ggcagctctc aggagactga caagctggcc ccggtgagca aaaggttccc     1800

tgtggggccc ccgaagaatg atgatacccc aaataggcag tactgggatg aagatctgtt     1860

aatgaaagtg ctggaatacc tcaaccaaga aaaggcagaa aagggaaggg agcatattgc     1920

taagagagca atggaaaata tgtaagctgc tttcattaat taccctactt tcattcctcc     1980

caccccaagc aaatcccaac atttctcttc agtgtgttga cttctatcct gttaacactg     2040

taatatcttt aaatgatgta caggcagatg aaaccaggtc actggggagt ctgcttcatt     2100

tcctctgagc tgttatcttg tgtatggata tgtgtaaatg ttatgactcc ttgataaaaa     2160

atttattatg tccattattc aagaaagata tctatgactg tgtttaatag tatatctaat     2220

ggctgtggca ttgttgatgc tcacatatga taaaaaagtg tcctataatt ctattgaaag     2280

tttttaatat ttattgaatt attttgttac tgtctgtagt gttttgtgga gtactggacc     2340

aaaaaaataa agcattataa atatatagtt ttatttataa ggccttttct attgtgtgtt     2400

ttactgttga ttaataaatg ttatttctgg acaa                                 2434


<210>  3
<211>  1854
<212>  DNA
<213>  Homo sapiens

<400>  3
atggctgaag caaagaccca ctggcttgga gcagccctgt ctcttatccc tttaattttc       60

ctcatctctg gggctgaagc agcttcattt cagagaaacc agctgcttca gaaagaacca      120

gacctcaggt tggaaaatgt ccaaaagttt cccagtcctg aaatgatcag ggctttggag      180

tacatagaaa acctccgaca acaagctcat aaggaagaaa gcagcccaga ttataatccc      240

taccaaggtg tctctgtccc ccttcagcaa aaagaaaatg gcgatgaaag ccacttgccc      300

gagagggatt cactgagtga agaagactgg atgagaataa tactcgaagc tttgagacag      360

gctgaaaatg agcctcagtc tgcaccaaaa gaaaataagc cctatgcctt gaattcagaa      420

aagaactttc caatggacat gagtgatgat tatgagacac agcagtggcc agaaagaaag      480

cttaagcaca tgcaattccc tcctatgtat gaagagaatt ccagggataa cccctttaaa      540

cgcacaaatg aaatagtgga ggaacaatat actcctcaaa gccttgctac attggaatct      600

gtcttccaag agctggggaa actgacagga ccaaacaacc agaaacgtga gaggatggat      660

gaggagcaaa aactttatac ggatgatgaa gatgatatct acaaggctaa taacattgcc      720

tatgaagatg tggtcggggg agaagactgg aacccagtag aggagaaaat agagagtcaa      780

acccaggaag aggtgagaga cagcaaagag aatatagaaa aaaatgaaca aatcaacgat      840

gagatgaaac gctcagggca gcttggcatc caggaagaag atcttcggaa agagagtaaa      900

gaccaactct cagatgatgt ctccaaagta attgcctatt tgaaaaggtt agtaaatgct      960

gcaggaagtg ggaggttaca gaatgggcaa aatggggaaa gggccaccag gctttttgag     1020

aaacctcttg attctcagtc tatttatcag ctgattgaaa tctcaaggaa tttacagata     1080

cccccagaag acttaattga gatgctcaaa actggggaga agccgaatgg atcagtggaa     1140

ccggagcggg agcttgacct tcctgttgac ctagatgaca tctcagaggc tgacttagac     1200

catccagacc tgttccaaaa taggatgctc tccaagagtg gctaccctaa aacacctggt     1260

cgtgctggga ctgaggccct accagacggg ctcagtgttg aggatatttt aaatctttta     1320

gggatggaga gtgcagcaaa tcagaaaacg tcgtattttc ccaatccata taaccaggag     1380

aaagttctgc caaggctccc ttatggtgct ggaagatcta gatcgaacca gcttcccaaa     1440

gctgcctgga ttccacatgt tgaaaacaga cagatggcat atgaaaacct gaacgacaag     1500

gatcaagaat taggtgagta cttggccagg atgctagtta aataccctga gatcattaat     1560

tcaaaccaag tgaagcgagt tcctggtcaa ggctcatctg aagatgacct gcaggaagag     1620

gaacaaattg agcaggccat caaagagcat ttgaatcaag gcagctctca ggagactgac     1680

aagctggccc cggtgagcaa aaggttccct gtggggcccc cgaagaatga tgatacccca     1740

aataggcagt actgggatga agatctgtta atgaaagtgc tggaatacct caaccaagaa     1800

aaggcagaaa agggaaggga gcatattgct aagagagcaa tggaaaatat gtaa           1854


<210>  4
<211>  617
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Glu Ala Lys Thr His Trp Leu Gly Ala Ala Leu Ser Leu Ile 
1               5                   10                  15      


Pro Leu Ile Phe Leu Ile Ser Gly Ala Glu Ala Ala Ser Phe Gln Arg 
            20                  25                  30          


Asn Gln Leu Leu Gln Lys Glu Pro Asp Leu Arg Leu Glu Asn Val Gln 
        35                  40                  45              


Lys Phe Pro Ser Pro Glu Met Ile Arg Ala Leu Glu Tyr Ile Glu Asn 
    50                  55                  60                  


Leu Arg Gln Gln Ala His Lys Glu Glu Ser Ser Pro Asp Tyr Asn Pro 
65                  70                  75                  80  


Tyr Gln Gly Val Ser Val Pro Leu Gln Gln Lys Glu Asn Gly Asp Glu 
                85                  90                  95      


Ser His Leu Pro Glu Arg Asp Ser Leu Ser Glu Glu Asp Trp Met Arg 
            100                 105                 110         


Ile Ile Leu Glu Ala Leu Arg Gln Ala Glu Asn Glu Pro Gln Ser Ala 
        115                 120                 125             


Pro Lys Glu Asn Lys Pro Tyr Ala Leu Asn Ser Glu Lys Asn Phe Pro 
    130                 135                 140                 


Met Asp Met Ser Asp Asp Tyr Glu Thr Gln Gln Trp Pro Glu Arg Lys 
145                 150                 155                 160 


Leu Lys His Met Gln Phe Pro Pro Met Tyr Glu Glu Asn Ser Arg Asp 
                165                 170                 175     


Asn Pro Phe Lys Arg Thr Asn Glu Ile Val Glu Glu Gln Tyr Thr Pro 
            180                 185                 190         


Gln Ser Leu Ala Thr Leu Glu Ser Val Phe Gln Glu Leu Gly Lys Leu 
        195                 200                 205             


Thr Gly Pro Asn Asn Gln Lys Arg Glu Arg Met Asp Glu Glu Gln Lys 
    210                 215                 220                 


Leu Tyr Thr Asp Asp Glu Asp Asp Ile Tyr Lys Ala Asn Asn Ile Ala 
225                 230                 235                 240 


Tyr Glu Asp Val Val Gly Gly Glu Asp Trp Asn Pro Val Glu Glu Lys 
                245                 250                 255     


Ile Glu Ser Gln Thr Gln Glu Glu Val Arg Asp Ser Lys Glu Asn Ile 
            260                 265                 270         


Glu Lys Asn Glu Gln Ile Asn Asp Glu Met Lys Arg Ser Gly Gln Leu 
        275                 280                 285             


Gly Ile Gln Glu Glu Asp Leu Arg Lys Glu Ser Lys Asp Gln Leu Ser 
    290                 295                 300                 


Asp Asp Val Ser Lys Val Ile Ala Tyr Leu Lys Arg Leu Val Asn Ala 
305                 310                 315                 320 


Ala Gly Ser Gly Arg Leu Gln Asn Gly Gln Asn Gly Glu Arg Ala Thr 
                325                 330                 335     


Arg Leu Phe Glu Lys Pro Leu Asp Ser Gln Ser Ile Tyr Gln Leu Ile 
            340                 345                 350         


Glu Ile Ser Arg Asn Leu Gln Ile Pro Pro Glu Asp Leu Ile Glu Met 
        355                 360                 365             


Leu Lys Thr Gly Glu Lys Pro Asn Gly Ser Val Glu Pro Glu Arg Glu 
    370                 375                 380                 


Leu Asp Leu Pro Val Asp Leu Asp Asp Ile Ser Glu Ala Asp Leu Asp 
385                 390                 395                 400 


His Pro Asp Leu Phe Gln Asn Arg Met Leu Ser Lys Ser Gly Tyr Pro 
                405                 410                 415     


Lys Thr Pro Gly Arg Ala Gly Thr Glu Ala Leu Pro Asp Gly Leu Ser 
            420                 425                 430         


Val Glu Asp Ile Leu Asn Leu Leu Gly Met Glu Ser Ala Ala Asn Gln 
        435                 440                 445             


Lys Thr Ser Tyr Phe Pro Asn Pro Tyr Asn Gln Glu Lys Val Leu Pro 
    450                 455                 460                 


Arg Leu Pro Tyr Gly Ala Gly Arg Ser Arg Ser Asn Gln Leu Pro Lys 
465                 470                 475                 480 


Ala Ala Trp Ile Pro His Val Glu Asn Arg Gln Met Ala Tyr Glu Asn 
                485                 490                 495     


Leu Asn Asp Lys Asp Gln Glu Leu Gly Glu Tyr Leu Ala Arg Met Leu 
            500                 505                 510         


Val Lys Tyr Pro Glu Ile Ile Asn Ser Asn Gln Val Lys Arg Val Pro 
        515                 520                 525             


Gly Gln Gly Ser Ser Glu Asp Asp Leu Gln Glu Glu Glu Gln Ile Glu 
    530                 535                 540                 


Gln Ala Ile Lys Glu His Leu Asn Gln Gly Ser Ser Gln Glu Thr Asp 
545                 550                 555                 560 


Lys Leu Ala Pro Val Ser Lys Arg Phe Pro Val Gly Pro Pro Lys Asn 
                565                 570                 575     


Asp Asp Thr Pro Asn Arg Gln Tyr Trp Asp Glu Asp Leu Leu Met Lys 
            580                 585                 590         


Val Leu Glu Tyr Leu Asn Gln Glu Lys Ala Glu Lys Gly Arg Glu His 
        595                 600                 605             


Ile Ala Lys Arg Ala Met Glu Asn Met 
    610                 615         


<210>  5
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  5

Thr Asn Glu Ile Val Glu Glu Gln Tyr Thr Pro Gln Ser Leu Ala Thr 
1               5                   10                  15      


Leu Glu Ser Val Phe Gln Glu Leu Gly Lys Leu Thr Gly Pro Asn Asn 
            20                  25                  30          


Gln 
    


<210>  6
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  6

Glu Arg Met Asp Glu Glu Gln Lys Leu Tyr Thr Asp Asp Glu Asp Asp 
1               5                   10                  15      


Ile Tyr Lys Ala Asn Asn Ile Ala Tyr Glu Asp Val Val Gly Gly Glu 
            20                  25                  30          


Asp Trp Asn Pro Val Glu Glu Lys Ile Glu Ser Gln Thr Gln Glu Glu 
        35                  40                  45              


Val Arg Asp Ser Lys Glu Asn Ile Glu Lys Asn Glu Gln Ile Asn Asp 
    50                  55                  60                  


Glu Met 
65      


<210>  7
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  7

Val Pro Gly Gln Gly Ser Ser Glu Asp Asp Leu Gln Glu Glu Glu Gln 
1               5                   10                  15      


Ile Glu Gln Ala Ile Lys Glu His Leu Asn Gln Gly Ser Ser Gln Glu 
            20                  25                  30          


Thr Asp Lys Leu Ala Pro Val Ser 
        35                  40  


<210>  8
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  8

Phe Pro Val Gly Pro Pro Lys Asn Asp Asp Thr Pro Asn Arg Gln Tyr 
1               5                   10                  15      


Trp Asp Glu Asp Leu Leu Met Lys Val Leu Glu Tyr Leu Asn Gln Glu 
            20                  25                  30          


Lys Ala Glu Lys Gly Arg Glu His Ile Ala 
        35                  40          


<210>  9
<211>  99
<212>  DNA
<213>  Homo sapiens

<400>  9
acaaatgaaa tagtggagga acaatatact cctcaaagcc ttgctacatt ggaatctgtc       60

ttccaagagc tggggaaact gacaggacca aacaaccag                              99


<210>  10
<211>  198
<212>  DNA
<213>  Homo sapiens

<400>  10
gagaggatgg atgaggagca aaaactttat acggatgatg aagatgatat ctacaaggct       60

aataacattg cctatgaaga tgtggtcggg ggagaagact ggaacccagt agaggagaaa      120

atagagagtc aaacccagga agaggtgaga gacagcaaag agaatataga aaaaaatgaa      180

caaatcaacg atgagatg                                                    198


<210>  11
<211>  120
<212>  DNA
<213>  Homo sapiens

<400>  11
gttcctggtc aaggctcatc tgaagatgac ctgcaggaag aggaacaaat tgagcaggcc       60

atcaaagagc atttgaatca aggcagctct caggagactg acaagctggc cccggtgagc      120


<210>  12
<211>  126
<212>  DNA
<213>  Homo sapiens

<400>  12
ttccctgtgg ggcccccgaa gaatgatgat accccaaata ggcagtactg ggatgaagat       60

ctgttaatga aagtgctgga atacctcaac caagaaaagg cagaaaaggg aagggagcat      120

attgct                                                                 126


<210>  13
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  13
acttacgctg agtacttcg                                                    19


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  14
ccttccactc aacagtcatt                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  15
gaattggctg gcgattcata                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  16
gataatgatc atgatccatt                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  17
gaagacattg cctgagctgt                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  18
gcagacaagc accttatgaa                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  19
cccttgattc tcagtctatt                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  20
gctcccaaag agataaacat                                                   20


<210>  21
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is a, c, g, or t

<400>  21
ntgantca                                                                 8


<210>  22
<211>  5
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  r is G or A

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  r is G or A

<400>  22
rgraa                                                                    5


<210>  23
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is a, c, g, or t

<400>  23
cncccac                                                                  7


<210>  24
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Met Phe Ser Gly Phe Asn Ala Asp Tyr Glu Ala Ser Ser Ser Arg 
1               5                   10                  15      


Cys Ser Ser Ala Ser Pro Ala Gly Asp Ser Leu Ser Tyr Tyr His Ser 
            20                  25                  30          


Pro Ala Asp Ser Phe Ser Ser Met Gly Ser Pro Val Asn Ala Gln Asp 
        35                  40                  45              


Phe Cys Thr Asp Leu Ala Val Ser Ser Ala Asn Phe Ile Pro Thr Val 
    50                  55                  60                  


Thr Ala Ile Ser Thr Ser Pro Asp Leu Gln Trp Leu Val Gln Pro Ala 
65                  70                  75                  80  


Leu Val Ser Ser Val Ala Pro Ser Gln Thr Arg Ala Pro His Pro Phe 
                85                  90                  95      


Gly Val Pro Ala Pro Ser Ala Gly Ala Tyr Ser Arg Ala Gly Val Val 
            100                 105                 110         


Lys Thr Met Thr Gly Gly Arg Ala Gln Ser Ile Gly Arg Arg Gly Lys 
        115                 120                 125             


Val Glu Gln Leu Ser Pro Glu Glu Glu Glu Lys Arg Arg Ile Arg Arg 
    130                 135                 140                 


Glu Arg Asn Lys Met Ala Ala Ala Lys Cys Arg Asn Arg Arg Arg Glu 
145                 150                 155                 160 


Leu Thr Asp Thr Leu Gln Ala Glu Thr Asp Gln Leu Glu Asp Glu Lys 
                165                 170                 175     


Ser Ala Leu Gln Thr Glu Ile Ala Asn Leu Leu Lys Glu Lys Glu Lys 
            180                 185                 190         


Leu Glu Phe Ile Leu Ala Ala His Arg Pro Ala Cys Lys Ile Pro Asp 
        195                 200                 205             


Asp Leu Gly Phe Pro Glu Glu Met Ser Val Ala Ser Leu Asp Leu Thr 
    210                 215                 220                 


Gly Gly Leu Pro Glu Val Ala Thr Pro Glu Ser Glu Glu Ala Phe Thr 
225                 230                 235                 240 


Leu Pro Leu Leu Asn Asp Pro Glu Pro Lys Pro Ser Val Glu Pro Val 
                245                 250                 255     


Lys Ser Ile Ser Ser Met Glu Leu Lys Thr Glu Pro Phe Asp Asp Phe 
            260                 265                 270         


Leu Phe Pro Ala Ser Ser Arg Pro Ser Gly Ser Glu Thr Ala Arg Ser 
        275                 280                 285             


Val Pro Asp Met Asp Leu Ser Gly Ser Phe Tyr Ala Ala Asp Trp Glu 
    290                 295                 300                 


Pro Leu His Ser Gly Ser Leu Gly Met Gly Pro Met Ala Thr Glu Leu 
305                 310                 315                 320 


Glu Pro Leu Cys Thr Pro Val Val Thr Cys Thr Pro Ser Cys Thr Ala 
                325                 330                 335     


Tyr Thr Ser Ser Phe Val Phe Thr Tyr Pro Glu Ala Asp Ser Phe Pro 
            340                 345                 350         


Ser Cys Ala Ala Ala His Arg Lys Gly Ser Ser Ser Asn Glu Pro Ser 
        355                 360                 365             


Ser Asp Ser Leu Ser Ser Pro Thr Leu Leu Ala Leu 
    370                 375                 380 


<210>  25
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Phe Gln Ala Phe Pro Gly Asp Tyr Asp Ser Gly Ser Arg Cys Ser 
1               5                   10                  15      


Ser Ser Pro Ser Ala Glu Ser Gln Tyr Leu Ser Ser Val Asp Ser Phe 
            20                  25                  30          


Gly Ser Pro Pro Thr Ala Ala Ala Ser Gln Glu Cys Ala Gly Leu Gly 
        35                  40                  45              


Glu Met Pro Gly Ser Phe Val Pro Thr Val Thr Ala Ile Thr Thr Ser 
    50                  55                  60                  


Gln Asp Leu Gln Trp Leu Val Gln Pro Thr Leu Ile Ser Ser Met Ala 
65                  70                  75                  80  


Gln Ser Gln Gly Gln Pro Leu Ala Ser Gln Pro Pro Val Val Asp Pro 
                85                  90                  95      


Tyr Asp Met Pro Gly Thr Ser Tyr Ser Thr Pro Gly Met Ser Gly Tyr 
            100                 105                 110         


Ser Ser Gly Gly Ala Ser Gly Ser Gly Gly Pro Ser Thr Ser Gly Thr 
        115                 120                 125             


Thr Ser Gly Pro Gly Pro Ala Arg Pro Ala Arg Ala Arg Pro Arg Arg 
    130                 135                 140                 


Pro Arg Glu Glu Thr Glu Thr Asp Gln Leu Glu Glu Glu Lys Ala Glu 
145                 150                 155                 160 


Leu Glu Ser Glu Ile Ala Glu Leu Gln Lys Glu Lys Glu Arg Leu Glu 
                165                 170                 175     


Phe Val Leu Val Ala His Lys Pro Gly Cys Lys Ile Pro Tyr Glu Glu 
            180                 185                 190         


Gly Pro Gly Pro Gly Pro Leu Ala Glu Val Arg Asp Leu Pro Gly Ser 
        195                 200                 205             


Ala Pro Ala Lys Glu Asp Gly Phe Ser Trp Leu Leu Pro Pro Pro Pro 
    210                 215                 220                 


Pro Pro Pro Leu Pro Phe Gln Thr Ser Gln Asp Ala Pro Pro Asn Leu 
225                 230                 235                 240 


Thr Ala Ser Leu Phe Thr His Ser Glu Val Gln Val Leu Gly Asp Pro 
                245                 250                 255     


Phe Pro Val Val Asn Pro Ser Tyr Thr Ser Ser Phe Val Leu Thr Cys 
            260                 265                 270         


Pro Glu Val Ser Ala Phe Ala Gly Ala Gln Arg Thr Ser Gly Ser Asp 
        275                 280                 285             


Gln Pro Ser Asp Pro Leu Asn Ser Pro Ser Leu Leu Ala Leu 
    290                 295                 300         


<210>  26
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Cys Thr Lys Met Glu Gln Pro Phe Tyr His Asp Asp Ser Tyr Thr 
1               5                   10                  15      


Ala Thr Gly Tyr Gly Arg Ala Pro Gly Gly Leu Ser Leu His Asp Tyr 
            20                  25                  30          


Lys Leu Leu Lys Pro Ser Leu Ala Val Asn Leu Ala Asp Pro Tyr Arg 
        35                  40                  45              


Ser Leu Lys Ala Pro Gly Ala Arg Gly Pro Gly Pro Glu Gly Gly Gly 
    50                  55                  60                  


Gly Gly Ser Tyr Phe Ser Gly Gln Gly Ser Asp Thr Gly Ala Ser Leu 
65                  70                  75                  80  


Lys Leu Ala Ser Ser Glu Leu Glu Arg Leu Ile Val Pro Asn Ser Asn 
                85                  90                  95      


Gly Val Ile Thr Thr Thr Pro Thr Pro Pro Gly Gln Tyr Phe Tyr Pro 
            100                 105                 110         


Arg Gly Gly Gly Ser Gly Gly Gly Ala Gly Gly Ala Gly Gly Gly Val 
        115                 120                 125             


Thr Glu Glu Gln Glu Gly Phe Ala Asp Gly Phe Val Lys Ala Leu Asp 
    130                 135                 140                 


Asp Leu His Lys Met Asn His Val Thr Pro Pro Asn Val Ser Leu Gly 
145                 150                 155                 160 


Ala Thr Gly Gly Pro Pro Ala Gly Pro Gly Gly Val Tyr Ala Gly Pro 
                165                 170                 175     


Glu Pro Pro Pro Val Tyr Thr Asn Leu Ser Ser Tyr Ser Pro Ala Ser 
            180                 185                 190         


Ala Ser Ser Gly Gly Ala Gly Ala Ala Val Gly Thr Gly Ser Ser Tyr 
        195                 200                 205             


Pro Thr Thr Thr Ile Ser Tyr Leu Pro His Ala Pro Pro Phe Ala Gly 
    210                 215                 220                 


Gly His Pro Ala Gln Leu Gly Leu Gly Arg Gly Ala Ser Thr Phe Lys 
225                 230                 235                 240 


Glu Glu Pro Gln Thr Val Pro Glu Ala Arg Ser Arg Asp Ala Thr Pro 
                245                 250                 255     


Pro Val Ser Pro Ile Asn Met Glu Asp Gln Glu Arg Ile Lys Val Glu 
            260                 265                 270         


Arg Lys Arg Leu Arg Asn Arg Leu Ala Ala Thr Lys Cys Arg Lys Arg 
        275                 280                 285             


Lys Leu Glu Arg Ile Ala Arg Leu Glu Asp Lys Val Lys Thr Leu Lys 
    290                 295                 300                 


Ala Glu Asn Ala Gly Leu Ser Ser Thr Ala Gly Leu Leu Arg Glu Gln 
305                 310                 315                 320 


Val Ala Gln Leu Lys Gln Lys Val Met Thr His Val Ser Asn Gly Cys 
                325                 330                 335     


Gln Leu Leu Leu Gly Val Lys Gly His Ala Phe 
            340                 345         


<210>  27
<211>  2104
<212>  DNA
<213>  Homo sapiens

<400>  27
aaccgcatct gcagcgagca tctgagaagc caagactgag ccggcggccg cggcgcagcg       60

aacgagcagt gaccgtgctc ctacccagct ctgctccaca gcgcccacct gtctccgccc      120

ctcggcccct cgcccggctt tgcctaaccg ccacgatgat gttctcgggc ttcaacgcag      180

actacgaggc gtcatcctcc cgctgcagca gcgcgtcccc ggccggggat agcctctctt      240

actaccactc acccgcagac tccttctcca gcatgggctc gcctgtcaac gcgcaggact      300

tctgcacgga cctggccgtc tccagtgcca acttcattcc cacggtcact gccatctcga      360

ccagtccgga cctgcagtgg ctggtgcagc ccgccctcgt ctcctccgtg gccccatcgc      420

agaccagagc ccctcaccct ttcggagtcc ccgccccctc cgctggggct tactccaggg      480

ctggcgttgt gaagaccatg acaggaggcc gagcgcagag cattggcagg aggggcaagg      540

tggaacagtt atctccagaa gaagaagaga aaaggagaat ccgaagggaa aggaataaga      600

tggctgcagc caaatgccgc aaccggagga gggagctgac tgatacactc caagcggaga      660

cagaccaact agaagatgag aagtctgctt tgcagaccga gattgccaac ctgctgaagg      720

agaaggaaaa actagagttc atcctggcag ctcaccgacc tgcctgcaag atccctgatg      780

acctgggctt cccagaagag atgtctgtgg cttcccttga tctgactggg ggcctgccag      840

aggttgccac cccggagtct gaggaggcct tcaccctgcc tctcctcaat gaccctgagc      900

ccaagccctc agtggaacct gtcaagagca tcagcagcat ggagctgaag accgagccct      960

ttgatgactt cctgttccca gcatcatcca ggcccagtgg ctctgagaca gcccgctccg     1020

tgccagacat ggacctatct gggtccttct atgcagcaga ctgggagcct ctgcacagtg     1080

gctccctggg gatggggccc atggccacag agctggagcc cctgtgcact ccggtggtca     1140

cctgtactcc cagctgcact gcttacacgt cttccttcgt cttcacctac cccgaggctg     1200

actccttccc cagctgtgca gctgcccacc gcaagggcag cagcagcaat gagccttcct     1260

ctgactcgct cagctcaccc acgctgctgg ccctgtgagg gggcagggaa ggggaggcag     1320

ccggcaccca caagtgccac tgcccgagct ggtgcattac agagaggaga aacacatctt     1380

ccctagaggg ttcctgtaga cctagggagg accttatctg tgcgtgaaac acaccaggct     1440

gtgggcctca aggacttgaa agcatccatg tgtggactca agtccttacc tcttccggag     1500

atgtagcaaa acgcatggag tgtgtattgt tcccagtgac acttcagaga gctggtagtt     1560

agtagcatgt tgagccaggc ctgggtctgt gtctcttttc tctttctcct tagtcttctc     1620

atagcattaa ctaatctatt gggttcatta ttggaattaa cctggtgctg gatattttca     1680

aattgtatct agtgcagctg attttaacaa taactactgt gttcctggca atagtgtgtt     1740

ctgattagaa atgaccaata ttatactaag aaaagatacg actttatttt ctggtagata     1800

gaaataaata gctatatcca tgtactgtag tttttcttca acatcaatgt tcattgtaat     1860

gttactgatc atgcattgtt gaggtggtct gaatgttctg acattaacag ttttccatga     1920

aaacgtttta ttgtgttttt aatttattta ttaagatgga ttctcagata tttatatttt     1980

tattttattt ttttctacct tgaggtcttt tgacatgtgg aaagtgaatt tgaatgaaaa     2040

atttaagcat tgtttgctta ttgttccaag acattgtcaa taaaagcatt taagttgaat     2100

gcga                                                                  2104


<210>  28
<211>  1143
<212>  DNA
<213>  Homo sapiens

<400>  28
atgatgttct cgggcttcaa cgcagactac gaggcgtcat cctcccgctg cagcagcgcg       60

tccccggccg gggatagcct ctcttactac cactcacccg cagactcctt ctccagcatg      120

ggctcgcctg tcaacgcgca ggacttctgc acggacctgg ccgtctccag tgccaacttc      180

attcccacgg tcactgccat ctcgaccagt ccggacctgc agtggctggt gcagcccgcc      240

ctcgtctcct ccgtggcccc atcgcagacc agagcccctc accctttcgg agtccccgcc      300

ccctccgctg gggcttactc cagggctggc gttgtgaaga ccatgacagg aggccgagcg      360

cagagcattg gcaggagggg caaggtggaa cagttatctc cagaagaaga agagaaaagg      420

agaatccgaa gggaaaggaa taagatggct gcagccaaat gccgcaaccg gaggagggag      480

ctgactgata cactccaagc ggagacagac caactagaag atgagaagtc tgctttgcag      540

accgagattg ccaacctgct gaaggagaag gaaaaactag agttcatcct ggcagctcac      600

cgacctgcct gcaagatccc tgatgacctg ggcttcccag aagagatgtc tgtggcttcc      660

cttgatctga ctgggggcct gccagaggtt gccaccccgg agtctgagga ggccttcacc      720

ctgcctctcc tcaatgaccc tgagcccaag ccctcagtgg aacctgtcaa gagcatcagc      780

agcatggagc tgaagaccga gccctttgat gacttcctgt tcccagcatc atccaggccc      840

agtggctctg agacagcccg ctccgtgcca gacatggacc tatctgggtc cttctatgca      900

gcagactggg agcctctgca cagtggctcc ctggggatgg ggcccatggc cacagagctg      960

gagcccctgt gcactccggt ggtcacctgt actcccagct gcactgctta cacgtcttcc     1020

ttcgtcttca cctaccccga ggctgactcc ttccccagct gtgcagctgc ccaccgcaag     1080

ggcagcagca gcaatgagcc ttcctctgac tcgctcagct cacccacgct gctggccctg     1140

tga                                                                   1143


<210>  29
<211>  3667
<212>  DNA
<213>  Homo sapiens

<400>  29
attcataaga ctcagagcta cggccacggc agggacacgc ggaaccaaga cttggaaact       60

tgattgttgt ggttcttctt gggggttatg aaatttcatt aatctttttt tttccgggga      120

gaaagttttt ggaaagattc ttccagatat ttcttcattt tcttttggag gaccgactta      180

ctttttttgg tcttctttat tactcccctc cccccgtggg acccgccgga cgcgtggagg      240

agaccgtagc tgaagctgat tctgtacagc gggacagcgc tttctgcccc tgggggagca      300

acccctccct cgcccctggg tcctacggag cctgcacttt caagaggtac agcggcatcc      360

tgtgggggcc tgggcaccgc aggaagactg cacagaaact ttgccattgt tggaacggga      420

cgttgctcct tccccgagct tccccggaca gcgtactttg aggactcgct cagctcaccg      480

gggactccca cggctcaccc cggacttgca ccttacttcc ccaacccggc catagccttg      540

gcttcccggc gacctcagcg tggtcacagg ggcccccctg tgcccaggga aatgtttcag      600

gctttccccg gagactacga ctccggctcc cggtgcagct cctcaccctc tgccgagtct      660

caatatctgt cttcggtgga ctccttcggc agtccaccca ccgccgccgc ctcccaggag      720

tgcgccggtc tcggggaaat gcccggttcc ttcgtgccca cggtcaccgc gatcacaacc      780

agccaggacc tccagtggct tgtgcaaccc accctcatct cttccatggc ccagtcccag      840

gggcagccac tggcctccca gcccccggtc gtcgacccct acgacatgcc gggaaccagc      900

tactccacac caggcatgag tggctacagc agtggcggag cgagtggcag tggtgggcct      960

tccaccagcg gaactaccag tgggcctggg cctgcccgcc cagcccgagc ccggcctagg     1020

agaccccgag aggagacgga gacagatcag ttggaggaag aaaaagcaga gctggagtcg     1080

gagatcgccg agctccaaaa ggagaaggaa cgtctggagt ttgtgctggt ggcccacaaa     1140

ccgggctgca agatccccta cgaagagggg cccgggccgg gcccgctggc ggaggtgaga     1200

gatttgccgg gctcagcacc ggctaaggaa gatggcttca gctggctgct gccgcccccg     1260

ccaccaccgc ccctgccctt ccagaccagc caagacgcac cccccaacct gacggcttct     1320

ctctttacac acagtgaagt tcaagtcctc ggcgacccct tccccgttgt taacccttcg     1380

tacacttctt cgtttgtcct cacctgcccg gaggtctccg cgttcgccgg cgcccaacgc     1440

accagcggca gtgaccagcc ttccgatccc ctgaactcgc cctccctcct cgctctgtga     1500

actctttaga cacacaaaac aaacaaacac atgggggaga gagacttgga agaggaggag     1560

gaggaggaga aggaggagag agaggggaag agacaaagtg ggtgtgtggc ctccctggct     1620

cctccgtctg accctctgcg gccactgcgc cactgccatc ggacaggagg attccttgtg     1680

ttttgtcctg cctcttgttt ctgtgccccg gcgaggccgg agagctggtg actttgggga     1740

cagggggtgg gaaggggatg gacaccccca gctgactgtt ggctctctga cgtcaaccca     1800

agctctgggg atgggtgggg aggggggcgg gtgacgccca ccttcgggca gtcctgtgtg     1860

aggattaagg gacgggggtg ggaggtaggc tgtggggtgg gctggagtcc tctccagaga     1920

ggctcaacaa ggaaaaatgc cactccctac ccaatgtctc ccacacccac cctttttttg     1980

gggtgcctag gttggtttcc cctgcactcc cgaccttagc ttattgatcc cacatttcca     2040

tggtgtgaga tcctctttac tctgggcaga agtgagcccc ccccttaaag ggaattcgat     2100

gcccccctag aataatctca tccccccacc cgacttcttt tgaaatgtga acgtccttcc     2160

ttgactgtct agccactccc tcccagaaaa actggctctg attggaattt ctggcctcct     2220

aaggctcccc accccgaaat cagcccccag ccttgtttct gatgacagtg ttatcccaag     2280

accctgcccc ctgccagccg accctcctgg ccttcctcgt tgggccgctc tgatttcagg     2340

cagcaggggc tgctgtgatg ccgtcctgct ggagtgattt atactgtgaa atgagttggc     2400

cagattgtgg ggtgcagctg ggtggggcag cacacctctg gggggataat gtccccactc     2460

ccgaaagcct ttcctcggtc tcccttccgt ccatccccct tcttcctccc ctcaacagtg     2520

agttagactc aagggggtga cagaaccgag aagggggtga cagtcctcca tccacgtggc     2580

ctctctctct ctcctcagga ccctcagccc tggccttttt ctttaaggtc ccccgaccaa     2640

tccccagcct aggacgccaa cttctcccac cccttggccc ctcacatcct ctccaggaag     2700

ggagtgaggg gctgtgacat ttttccggag aagatttcag agctgaggct ttggtacccc     2760

caaaccccca atatttttgg actggcagac tcaaggggct ggaatctcat gattccatgc     2820

ccgagtccgc ccatccctga ccatggtttt ggctctccca ccccgccgtt ccctgcgctt     2880

catctcatga ggatttcttt atgaggcaaa tttatatttt ttaatatcgg ggggtggacc     2940

acgccgccct ccatccgtgc tgcatgaaaa acattccacg tgccccttgt cgcgcgtctc     3000

ccatcctgat cccagaccca ttccttagct atttatccct ttcctggttt ccgaaaggca     3060

attatatcta ttatgtataa gtaaatatat tatatatgga tgtgtgtgtg tgcgtgcgcg     3120

tgagtgtgtg agcgcttctg cagcctcggc ctaggtcacg ttggccctca aagcgagccg     3180

ttgaattgga aactgcttct agaaactctg gctcagcctg tctcgggctg acccttttct     3240

gatcgtctcg gcccctctga ttgttcccga tggtctctct ccctctgtct tttctcctcc     3300

gcctgtgtcc atctgaccgt tttcacttgt ctcctttctg actgtccctg ccaatgctcc     3360

agctgtcgtc tgactctggg ttcgttgggg acatgagatt ttattttttg tgagtgagac     3420

tgagggatcg tagattttta caatctgtat ctttgacaat tctgggtgcg agtgtgagag     3480

tgtgagcagg gcttgctcct gccaaccaca attcaatgaa tccccgaccc ccctacccca     3540

tgctgtactt gtggttctct ttttgtattt tgcatctgac cccggggggc tgggacagat     3600

tggcaatggg ccgtcccctc tccccttggt tctgcactgt tgccaataaa aagctcttaa     3660

aaacgca                                                               3667


<210>  30
<211>  909
<212>  DNA
<213>  Homo sapiens

<400>  30
atgtttcagg ctttccccgg agactacgac tccggctccc ggtgcagctc ctcaccctct       60

gccgagtctc aatatctgtc ttcggtggac tccttcggca gtccacccac cgccgccgcc      120

tcccaggagt gcgccggtct cggggaaatg cccggttcct tcgtgcccac ggtcaccgcg      180

atcacaacca gccaggacct ccagtggctt gtgcaaccca ccctcatctc ttccatggcc      240

cagtcccagg ggcagccact ggcctcccag cccccggtcg tcgaccccta cgacatgccg      300

ggaaccagct actccacacc aggcatgagt ggctacagca gtggcggagc gagtggcagt      360

ggtgggcctt ccaccagcgg aactaccagt gggcctgggc ctgcccgccc agcccgagcc      420

cggcctagga gaccccgaga ggagacggag acagatcagt tggaggaaga aaaagcagag      480

ctggagtcgg agatcgccga gctccaaaag gagaaggaac gtctggagtt tgtgctggtg      540

gcccacaaac cgggctgcaa gatcccctac gaagaggggc ccgggccggg cccgctggcg      600

gaggtgagag atttgccggg ctcagcaccg gctaaggaag atggcttcag ctggctgctg      660

ccgcccccgc caccaccgcc cctgcccttc cagaccagcc aagacgcacc ccccaacctg      720

acggcttctc tctttacaca cagtgaagtt caagtcctcg gcgacccctt ccccgttgtt      780

aacccttcgt acacttcttc gtttgtcctc acctgcccgg aggtctccgc gttcgccggc      840

gcccaacgca ccagcggcag tgaccagcct tccgatcccc tgaactcgcc ctccctcctc      900

gctctgtga                                                              909


<210>  31
<211>  1830
<212>  DNA
<213>  Homo sapiens

<400>  31
gggaccttga gagcggccag gccagcctcg gagccagcag ggagctggga gctgggggaa       60

acgacgccag gaaagctatc gcgccagaga gggcgacggg ggctcgggaa gcctgacagg      120

gcttttgcgc acagctgccg gctggctgct acccgcccgc gccagccccc gagaacgcgc      180

gaccaggcac ccagtccggt caccgcagcg gagagctcgc cgctcgctgc agcgaggccc      240

ggagcggccc cgcagggacc ctccccagac cgcctgggcc gcccggatgt gcactaaaat      300

ggaacagccc ttctaccacg acgactcata cacagctacg ggatacggcc gggcccctgg      360

tggcctctct ctacacgact acaaactcct gaaaccgagc ctggcggtca acctggccga      420

cccctaccgg agtctcaaag cgcctggggc tcgcggaccc ggcccagagg gcggcggtgg      480

cggcagctac ttttctggtc agggctcgga caccggcgcg tctctcaagc tcgcctcttc      540

ggagctggaa cgcctgattg tccccaacag caacggcgtg atcacgacga cgcctacacc      600

cccgggacag tacttttacc cccgcggggg tggcagcggt ggaggtgcag ggggcgcagg      660

gggcggcgtc accgaggagc aggagggctt cgccgacggc tttgtcaaag ccctggacga      720

tctgcacaag atgaaccacg tgacaccccc caacgtgtcc ctgggcgcta ccggggggcc      780

cccggctggg cccgggggcg tctacgccgg cccggagcca cctcccgttt acaccaacct      840

cagcagctac tccccagcct ctgcgtcctc gggaggcgcc ggggctgccg tcgggaccgg      900

gagctcgtac ccgacgacca ccatcagcta cctcccacac gcgccgccct tcgccggtgg      960

ccacccggcg cagctgggct tgggccgcgg cgcctccacc ttcaaggagg aaccgcagac     1020

cgtgccggag gcgcgcagcc gggacgccac gccgccggtg tcccccatca acatggaaga     1080

ccaagagcgc atcaaagtgg agcgcaagcg gctgcggaac cggctggcgg ccaccaagtg     1140

ccggaagcgg aagctggagc gcatcgcgcg cctggaggac aaggtgaaga cgctcaaggc     1200

cgagaacgcg gggctgtcga gtaccgccgg cctcctccgg gagcaggtgg cccagctcaa     1260

acagaaggtc atgacccacg tcagcaacgg ctgtcagctg ctgcttgggg tcaagggaca     1320

cgccttctga acgtcccctg cccctttacg gacaccccct cgcttggacg gctgggcaca     1380

cgcctcccac tggggtccag ggagcaggcg gtgggcaccc accctgggac ctaggggcgc     1440

cgcaaaccac actggactcc ggccctccta ccctgcgccc agtccttcca cctcgacgtt     1500

tacaagcccc cccttccact tttttttgta tgtttttttt ctgctggaaa cagactcgat     1560

tcatattgaa tataatatat ttgtgtattt aacagggagg ggaagagggg gcgatcgcgg     1620

cggagctggc cccgccgcct ggtactcaag cccgcgggga cattgggaag gggacccccg     1680

ccccctgccc tcccctctct gcaccgtact gtggaaaaga aacacgcact tagtctctaa     1740

agagtttatt ttaagacgtg tttgtgtttg tgtgtgtttg ttctttttat tgaatctatt     1800

taagtaaaaa aaaaattggt tctttattaa                                      1830


<210>  32
<211>  1044
<212>  DNA
<213>  Homo sapiens

<400>  32
atgtgcacta aaatggaaca gcccttctac cacgacgact catacacagc tacgggatac       60

ggccgggccc ctggtggcct ctctctacac gactacaaac tcctgaaacc gagcctggcg      120

gtcaacctgg ccgaccccta ccggagtctc aaagcgcctg gggctcgcgg acccggccca      180

gagggcggcg gtggcggcag ctacttttct ggtcagggct cggacaccgg cgcgtctctc      240

aagctcgcct cttcggagct ggaacgcctg attgtcccca acagcaacgg cgtgatcacg      300

acgacgccta cacccccggg acagtacttt tacccccgcg ggggtggcag cggtggaggt      360

gcagggggcg cagggggcgg cgtcaccgag gagcaggagg gcttcgccga cggctttgtc      420

aaagccctgg acgatctgca caagatgaac cacgtgacac cccccaacgt gtccctgggc      480

gctaccgggg ggcccccggc tgggcccggg ggcgtctacg ccggcccgga gccacctccc      540

gtttacacca acctcagcag ctactcccca gcctctgcgt cctcgggagg cgccggggct      600

gccgtcggga ccgggagctc gtacccgacg accaccatca gctacctccc acacgcgccg      660

cccttcgccg gtggccaccc ggcgcagctg ggcttgggcc gcggcgcctc caccttcaag      720

gaggaaccgc agaccgtgcc ggaggcgcgc agccgggacg ccacgccgcc ggtgtccccc      780

atcaacatgg aagaccaaga gcgcatcaaa gtggagcgca agcggctgcg gaaccggctg      840

gcggccacca agtgccggaa gcggaagctg gagcgcatcg cgcgcctgga ggacaaggtg      900

aagacgctca aggccgagaa cgcggggctg tcgagtaccg ccggcctcct ccgggagcag      960

gtggcccagc tcaaacagaa ggtcatgacc cacgtcagca acggctgtca gctgctgctt     1020

ggggtcaagg gacacgcctt ctga                                            1044


<210>  33
<211>  577
<212>  PRT
<213>  Mus musculus

<400>  33

Met Ala Gly Ala Lys Ala Tyr Arg Leu Gly Ala Val Leu Leu Leu Ile 
1               5                   10                  15      


His Leu Ile Phe Leu Ile Ser Gly Ala Glu Ala Ala Ser Phe Gln Arg 
            20                  25                  30          


Asn Gln Leu Leu Gln Lys Glu Pro Asp Leu Arg Leu Glu Asn Val Gln 
        35                  40                  45              


Lys Phe Pro Ser Pro Glu Met Ile Arg Ala Leu Glu Tyr Ile Glu Lys 
    50                  55                  60                  


Leu Arg Gln Gln Ala His Arg Glu Glu Ser Ser Pro Asp Tyr Asn Pro 
65                  70                  75                  80  


Tyr Gln Gly Val Ser Val Pro Leu Gln Leu Lys Glu Asn Gly Glu Glu 
                85                  90                  95      


Ser His Leu Ala Glu Ser Ser Arg Asp Ala Leu Ser Glu Asp Glu Trp 
            100                 105                 110         


Met Arg Ile Ile Leu Glu Ala Leu Arg Gln Ala Glu Asn Glu Pro Pro 
        115                 120                 125             


Ser Ala Pro Lys Glu Asn Lys Pro Tyr Ala Leu Asn Leu Glu Lys Asn 
    130                 135                 140                 


Phe Pro Val Asp Thr Pro Asp Asp Tyr Glu Thr Gln Gln Trp Pro Glu 
145                 150                 155                 160 


Arg Lys Leu Lys His Met Arg Phe Pro Leu Met Tyr Glu Glu Asn Ser 
                165                 170                 175     


Arg Glu Asn Pro Phe Lys Arg Thr Asn Glu Ile Val Glu Glu Gln Tyr 
            180                 185                 190         


Thr Pro Gln Ser Leu Ala Thr Leu Glu Ser Val Phe Gln Glu Leu Gly 
        195                 200                 205             


Lys Leu Thr Gly Pro Ser Asn Gln Lys Arg Glu Arg Val Asp Glu Glu 
    210                 215                 220                 


Gln Lys Leu Tyr Thr Asp Asp Glu Asp Asp Val Tyr Lys Thr Asn Asn 
225                 230                 235                 240 


Ile Ala Tyr Glu Asp Val Val Gly Gly Glu Asp Trp Ser Pro Ile Glu 
                245                 250                 255     


Glu Lys Ile Glu Thr Gln Thr Gln Glu Glu Val Arg Asp Ser Lys Glu 
            260                 265                 270         


Asn Thr Glu Lys Asn Glu Gln Ile Asn Glu Glu Met Lys Arg Ser Gly 
        275                 280                 285             


Gln Leu Gly Leu Pro Asp Glu Glu Asn Arg Arg Glu Ser Lys Asp Gln 
    290                 295                 300                 


Leu Ser Glu Asp Ala Ser Lys Val Ile Thr Tyr Leu Arg Arg Asn Leu 
305                 310                 315                 320 


Gln Ile Pro Pro Glu Asp Leu Ile Glu Met Leu Lys Ala Gly Glu Lys 
                325                 330                 335     


Pro Asn Gly Leu Val Glu Pro Glu Gln Asp Leu Glu Leu Ala Val Asp 
            340                 345                 350         


Leu Asp Asp Ile Pro Glu Ala Asp Leu Asp Arg Pro Asp Met Phe Gln 
        355                 360                 365             


Ser Lys Met Leu Ser Lys Gly Gly Tyr Pro Lys Ala Pro Gly Arg Gly 
    370                 375                 380                 


Met Val Glu Ala Leu Pro Asp Gly Leu Ser Val Glu Asp Ile Leu Asn 
385                 390                 395                 400 


Val Leu Gly Met Glu Asn Val Val Asn Gln Lys Ser Pro Tyr Phe Pro 
                405                 410                 415     


Asn Gln Tyr Ser Gln Asp Lys Ala Leu Met Arg Leu Pro Tyr Gly Pro 
            420                 425                 430         


Gly Lys Ser Arg Ala Asn Gln Ile Pro Lys Val Ala Trp Ile Pro Asp 
        435                 440                 445             


Val Glu Ser Arg Gln Ala Pro Tyr Glu Asn Leu Asn Asp Gln Glu Leu 
    450                 455                 460                 


Gly Glu Tyr Leu Ala Arg Met Leu Val Lys Tyr Pro Glu Leu Leu Asn 
465                 470                 475                 480 


Thr Asn Gln Leu Lys Arg Val Pro Ser Pro Val Ser Ser Glu Asp Asp 
                485                 490                 495     


Leu Gln Glu Glu Glu Gln Leu Glu Gln Ala Ile Lys Glu His Leu Gly 
            500                 505                 510         


Pro Gly Ser Ser Gln Glu Met Glu Arg Leu Ala Lys Val Ser Lys Arg 
        515                 520                 525             


Ile Pro Val Gly Ser Leu Lys Asn Glu Asp Thr Pro Asn Arg Gln Tyr 
    530                 535                 540                 


Leu Asp Glu Asp Met Leu Leu Lys Val Leu Glu Tyr Leu Asn Gln Glu 
545                 550                 555                 560 


Gln Ala Glu Gln Gly Arg Glu His Leu Ala Lys Arg Ala Met Glu Asn 
                565                 570                 575     


Met 
    


<210>  34
<211>  619
<212>  PRT
<213>  Rattus norvegicus

<400>  34

Met Ala Glu Ser Lys Ala Tyr Arg Phe Gly Ala Val Leu Leu Leu Ile 
1               5                   10                  15      


His Leu Ile Phe Leu Val Pro Gly Thr Glu Ala Ala Ser Phe Gln Arg 
            20                  25                  30          


Asn Gln Leu Leu Gln Lys Glu Pro Asp Leu Arg Leu Glu Asn Val Gln 
        35                  40                  45              


Lys Phe Pro Ser Pro Glu Met Ile Arg Ala Leu Glu Tyr Ile Glu Lys 
    50                  55                  60                  


Leu Arg Gln Gln Ala His Arg Glu Glu Ser Ser Pro Asp Tyr Asn Pro 
65                  70                  75                  80  


Tyr Gln Gly Ile Ser Val Pro Leu Gln Leu Lys Glu Asn Gly Glu Glu 
                85                  90                  95      


Ser His Leu Ala Glu Ser Ser Arg Asp Val Leu Ser Glu Asp Glu Trp 
            100                 105                 110         


Met Arg Ile Ile Leu Glu Ala Leu Arg Gln Ala Glu Asn Glu Pro Pro 
        115                 120                 125             


Ser Ala Leu Lys Glu Asn Lys Pro Tyr Ala Leu Asn Leu Glu Lys Asn 
    130                 135                 140                 


Phe Pro Val Asp Thr Pro Asp Asp Tyr Glu Thr Gln Gln Trp Pro Glu 
145                 150                 155                 160 


Arg Lys Leu Lys His Met Arg Phe Pro Leu Met Tyr Glu Glu Asn Ser 
                165                 170                 175     


Arg Glu Asn Pro Phe Lys Arg Thr Asn Glu Ile Val Glu Glu Gln Tyr 
            180                 185                 190         


Thr Pro Gln Ser Leu Ala Thr Leu Glu Ser Val Phe Gln Glu Leu Gly 
        195                 200                 205             


Lys Leu Thr Gly Pro Ser Asn Gln Lys Arg Glu Arg Val Asp Glu Glu 
    210                 215                 220                 


Gln Lys Leu Tyr Thr Asp Asp Glu Asp Asp Val Tyr Lys Thr Asn Asn 
225                 230                 235                 240 


Ile Ala Tyr Glu Asp Val Val Gly Gly Glu Asp Trp Ser Pro Met Glu 
                245                 250                 255     


Glu Lys Ile Glu Thr Gln Thr Gln Glu Glu Val Arg Asp Ser Lys Glu 
            260                 265                 270         


Asn Thr Glu Lys Asn Glu Gln Ile Asn Glu Glu Met Lys Arg Ser Gly 
        275                 280                 285             


His Leu Gly Leu Pro Asp Glu Gly Asn Arg Lys Glu Ser Lys Asp Gln 
    290                 295                 300                 


Leu Ser Glu Asp Ala Ser Lys Val Ile Thr Tyr Leu Arg Arg Leu Val 
305                 310                 315                 320 


Asn Ala Val Gly Ser Gly Arg Ser Gln Ser Gly Gln Asn Gly Asp Arg 
                325                 330                 335     


Ala Ala Arg Leu Leu Glu Arg Pro Leu Asp Ser Gln Ser Ile Tyr Gln 
            340                 345                 350         


Leu Ile Glu Ile Ser Arg Asn Leu Gln Ile Pro Pro Glu Asp Leu Ile 
        355                 360                 365             


Glu Met Leu Lys Ala Gly Glu Lys Pro Asn Gly Leu Val Glu Pro Glu 
    370                 375                 380                 


Gln Asp Leu Glu Leu Ala Val Asp Leu Asp Asp Ile Pro Glu Ala Asp 
385                 390                 395                 400 


Ile Asp Arg Pro Asp Met Phe Gln Ser Lys Thr Leu Ser Lys Gly Gly 
                405                 410                 415     


Tyr Pro Lys Ala Pro Gly Arg Gly Met Met Glu Ala Leu Pro Asp Gly 
            420                 425                 430         


Leu Ser Val Glu Asp Ile Leu Asn Val Leu Gly Met Glu Asn Val Ala 
        435                 440                 445             


Asn Gln Lys Ser Pro Tyr Phe Pro Asn Gln Tyr Ser Arg Asp Lys Ala 
    450                 455                 460                 


Leu Leu Arg Leu Pro Tyr Gly Pro Gly Lys Ser Arg Ala Asn Gln Ile 
465                 470                 475                 480 


Pro Lys Val Ala Trp Ile Pro Asp Val Glu Ser Arg Gln Ala Pro Tyr 
                485                 490                 495     


Asp Asn Leu Asn Asp Lys Asp Gln Glu Leu Gly Glu Tyr Leu Ala Arg 
            500                 505                 510         


Met Leu Val Lys Tyr Pro Glu Leu Met Asn Thr Asn Gln Leu Lys Arg 
        515                 520                 525             


Val Pro Ser Pro Gly Ser Ser Glu Asp Asp Leu Gln Glu Glu Glu Gln 
    530                 535                 540                 


Leu Glu Gln Ala Ile Lys Glu His Leu Gly Gln Gly Ser Ser Gln Glu 
545                 550                 555                 560 


Met Glu Lys Leu Ala Lys Val Ser Lys Arg Ile Pro Ala Gly Ser Leu 
                565                 570                 575     


Lys Asn Glu Asp Thr Pro Asn Arg Gln Tyr Leu Asp Glu Asp Met Leu 
            580                 585                 590         


Leu Lys Val Leu Glu Tyr Leu Asn Gln Glu Gln Ala Glu Gln Gly Arg 
        595                 600                 605             


Glu His Leu Ala Lys Arg Ala Met Glu Asn Met 
    610                 615                 


<210>  35
<211>  616
<212>  PRT
<213>  Pan troglodytes

<400>  35

Met Ala Glu Ala Lys Thr His Trp Leu Gly Ala Ala Leu Ser Leu Ile 
1               5                   10                  15      


Pro Leu Ile Phe Leu Ile Ser Gly Ala Glu Ala Ala Ser Phe Gln Arg 
            20                  25                  30          


Asn Gln Leu Leu Gln Lys Glu Pro Asp Leu Arg Leu Glu Asn Val Gln 
        35                  40                  45              


Lys Phe Pro Ser Pro Glu Met Ile Arg Ala Leu Glu Tyr Ile Glu Lys 
    50                  55                  60                  


Leu Arg Gln Gln Ala His Lys Glu Glu Ser Ser Pro Asp Tyr Asn Pro 
65                  70                  75                  80  


Tyr Gln Gly Val Ser Val Pro Leu Gln Gln Lys Glu Asn Gly Asp Glu 
                85                  90                  95      


Ser His Leu Pro Glu Arg Asp Ser Leu Ser Glu Glu Asp Trp Met Arg 
            100                 105                 110         


Ile Ile Leu Glu Ala Leu Arg Gln Ala Glu Asn Glu Pro Gln Ser Ala 
        115                 120                 125             


Pro Lys Glu Asn Lys Pro Tyr Ala Leu Asn Ser Glu Lys Asn Phe Pro 
    130                 135                 140                 


Met Asp Met Ser Asp Asp Tyr Glu Thr Gln Gln Trp Pro Glu Arg Lys 
145                 150                 155                 160 


Leu Lys His Met Gln Phe Pro Pro Met Tyr Glu Glu Asn Ser Arg Asp 
                165                 170                 175     


Asn Pro Phe Lys Arg Thr Asn Glu Ile Val Glu Glu Gln Tyr Thr Pro 
            180                 185                 190         


Gln Ser Leu Ala Thr Leu Glu Ser Val Phe Gln Glu Leu Gly Lys Leu 
        195                 200                 205             


Thr Gly Pro Asn Asn Gln Lys Arg Glu Arg Met Asp Glu Glu Gln Lys 
    210                 215                 220                 


Leu Tyr Thr Asp Asp Asp Asp Ile Tyr Lys Ala Asn Asn Ile Ala Tyr 
225                 230                 235                 240 


Glu Asp Val Val Gly Gly Glu Asp Trp Asn Pro Val Glu Glu Lys Ile 
                245                 250                 255     


Glu Ser Gln Thr Gln Glu Glu Val Arg Asp Ser Lys Glu Asn Ile Glu 
            260                 265                 270         


Lys Asn Glu Gln Ile Asn Asp Glu Met Lys Arg Ser Gly Gln Leu Gly 
        275                 280                 285             


Ile Gln Glu Glu Asp Leu Arg Lys Glu Ser Lys Asp Gln Leu Ser Asp 
    290                 295                 300                 


Asp Val Ser Lys Val Ile Ala Tyr Leu Lys Arg Leu Val Asn Ala Ala 
305                 310                 315                 320 


Gly Ser Gly Arg Leu Gln Asn Gly Gln Asn Gly Glu Arg Ala Thr Arg 
                325                 330                 335     


Leu Phe Glu Lys Pro Leu Asp Ser Gln Ser Ile Tyr Gln Leu Ile Glu 
            340                 345                 350         


Ile Ser Arg Asn Leu Gln Ile Pro Pro Glu Asp Leu Ile Glu Met Leu 
        355                 360                 365             


Lys Thr Gly Glu Lys Pro Asn Gly Ser Val Glu Pro Glu Arg Glu Leu 
    370                 375                 380                 


Asp Leu Pro Val Asp Leu Asp Asp Ile Ser Glu Ala Asp Leu Asp His 
385                 390                 395                 400 


Pro Asp Leu Phe Gln Asn Lys Met Leu Ser Lys Ser Gly Tyr Pro Lys 
                405                 410                 415     


Thr Pro Gly Arg Ala Gly Thr Glu Ala Leu Pro Asp Gly Leu Ser Val 
            420                 425                 430         


Glu Asp Ile Leu Asn Leu Leu Gly Met Glu Ser Ala Ala Asn Gln Lys 
        435                 440                 445             


Thr Ser Tyr Phe Pro Asn Pro Tyr Asn Gln Glu Lys Val Leu Pro Arg 
    450                 455                 460                 


Leu Pro Tyr Gly Pro Gly Arg Ser Arg Ser Asn Gln Leu Pro Lys Ala 
465                 470                 475                 480 


Ala Trp Ile Pro Tyr Val Glu Asn Arg Gln Met Ala Tyr Glu Asn Leu 
                485                 490                 495     


Asn Asp Lys Asp Gln Glu Leu Gly Glu Tyr Leu Ala Arg Met Leu Val 
            500                 505                 510         


Lys Tyr Pro Glu Ile Ile Asn Ser Asn Gln Val Lys Arg Val Pro Gly 
        515                 520                 525             


Gln Gly Ser Ser Glu Asp Asp Leu Gln Glu Glu Glu Gln Ile Glu Gln 
    530                 535                 540                 


Ala Ile Lys Glu His Leu Asn Gln Gly Ser Ser Gln Glu Thr Asp Lys 
545                 550                 555                 560 


Leu Ala Pro Val Ser Lys Arg Phe Pro Val Gly Pro Pro Lys Asn Asp 
                565                 570                 575     


Asp Thr Pro Asn Arg Gln Tyr Leu Asp Glu Asp Leu Leu Met Lys Val 
            580                 585                 590         


Leu Glu Tyr Leu Asn Gln Glu Lys Ala Glu Lys Gly Arg Glu His Ile 
        595                 600                 605             


Ala Lys Arg Ala Met Glu Asn Met 
    610                 615     


<210>  36
<211>  2604
<212>  DNA
<213>  Mus musculus

<400>  36
aaacggcccg agccctcact cagcggcaga gaggagcatg cttggagcct tccacataat       60

ataagacaga ggaaatcttt aagacatggc tggagctaag gcgtaccgac ttggagcagt      120

tctgcttctt atccacttaa ttttcctcat ctctggagcc gaagcagctt ccttccagcg      180

aaaccagctg cttcagaaag aaccagacct cagattggag aatgtccaaa agtttcctag      240

tccagaaatg atcagggctt tggagtacat agaaaagctc aggcagcaag ctcacagaga      300

agaaagcagc ccagactaca atccctacca aggcgtctct gttcctcttc aactcaaaga      360

aaacggagaa gaaagccact tggcagagag ctcaagggat gcactgagtg aagacgagtg      420

gatgcggata atactcgagg ctctgaggca ggctgaaaat gagccgccat ctgcccccaa      480

agagaacaag ccctatgcct tgaatctgga gaagaacttc ccagtggaca cgcctgatga      540

ctatgagact caacagtggc ctgagaggaa actcaagcac atgcggttcc ctctcatgta      600

tgaagagaat tccagagaaa accccttcaa acgcacaaat gaaatagtcg aggaacaata      660

cacaccccaa agtcttgcta ccctggagtc tgtgttccaa gagcttggga aactgacagg      720

gccaagcaac cagaagcgtg agagggttga cgaggaacaa aagctgtaca cagatgatga      780

agacgacgtg tacaagacca acaacattgc ctatgaagat gtcgtggggg gagaagactg      840

gagccccata gaggagaaaa tagagactca aacccaggaa gaggtgagag acagcaaaga      900

gaacacagaa aaaaatgaac aaatcaatga agagatgaaa cgttcagggc agttggggct      960

cccagatgaa gaaaaccgga gagagagtaa agaccaactc tcagaggatg cctccaaagt     1020

tatcacctac ctgagaagga atttgcagat accccctgaa gatttaattg agatgctcaa     1080

agctggagag aagccaaatg ggttggtgga gccagagcag gatctggagc ttgctgttga     1140

cctagatgac atcccagagg ctgacctaga ccgtccagac atgtttcaaa gtaagatgct     1200

ctccaagggt gggtatccca aggcacctgg tcgtggtatg gtagaggcct tgcctgatgg     1260

gctgagtgtc gaggacattt taaatgtttt agggatggag aatgtagtaa atcagaagtc     1320

cccatatttt cccaaccaat atagccaaga caaggctctg atgaggctcc cttatggtcc     1380

tgggaaatct agagccaacc agattcccaa agtagcctgg atccctgatg ttgaaagcag     1440

acaagcacct tatgaaaatc tgaatgacca agaattggga gagtacttag ccaggatgct     1500

agttaagtac cctgagctcc tgaataccaa ccagctgaag agagtgccca gtccagtctc     1560

ctcagaggat gacctccaag aagaagagca gctcgagcag gccatcaagg aacatctggg     1620

gccaggaagc tcccaggaaa tggagagact ggccaaggtg agcaaaagga tccccgtagg     1680

atccctgaag aatgaggaca ccccaaacag acagtacctg gatgaagata tgctcctgaa     1740

agtgctggag tacctcaacc aagagcaggc agagcagggg agggagcatc ttgccaagcg     1800

ggccatggaa aacatgtaaa cagctttaat gcccaatttc ccttctttcc cccaagtaag     1860

ccccctacat ttctcttaag tgtgttgatc tctatcctgt tgacagtgta atatctttaa     1920

agtgatgtat aggcagatga ctccaggtca ttttggggga tctgcttcac ttattctgag     1980

ctgttacgtt gtgtgtggat gtgtgtaaat gttatgattc ccagattgaa aaaaaatgtt     2040

ctttattcaa gaaagatatc tatgatagtg ttggctaatg tatctaatgg tcatggaatt     2100

gatgatgctc acatatgata aagagtatcc tataattatc ttggaagttt ttaacattta     2160

ttgaattatt ttgttactgt ctgtagtgtt ttgtggagtt ctggagcaaa accaataaag     2220

cattataaat atatagtttt acttataagg ccttttctat tgtgtgtttt attgttgatt     2280

aataaatgtt atttctggat acctttggac tttttattct ggaaaccaga gacaactggt     2340

atggatcaag cagcatggag ccagaggaga aaattattac tgtccacagg caacccaggt     2400

aagagatgaa tcttatatgt gatcatattt tctgcctaca ggatgttgtg aacattcccg     2460

aacagcctta catcttttca tgttttccat atacctcatt aacaaaacga gactttgggt     2520

ataattctta cacttcacat tgattcatat aagtaaaaga tattaaactt tccccactca     2580

tcacaatttg aaaatgaaag aaaa                                            2604


<210>  37
<211>  2291
<212>  DNA
<213>  Rattus norvegicus

<400>  37
acaatataag acagaggaaa attttaagac atggctgaat cgaaggctta ccgatttgga       60

gcagttctgc ttcttatcca cttaattttc cttgtccctg gaaccgaagc agcttccttc      120

cagcgaaacc agctgcttca gaaagaacca gacctcagat tggagaatgt ccagaagttt      180

cctagtccag aaatgatcag ggctttggag tacatagaaa agctcaggca gcaggcccac      240

agagaagaaa gcagcccaga ctacaatccc taccaaggca tctctgttcc ccttcaactc      300

aaagaaaacg gagaagaaag tcacttggca gagagctcaa gggatgtctt gagtgaagac      360

gagtggatgc ggataatact tgaggctttg aggcaggctg aaaatgagcc gccatctgcc      420

ctcaaggaga acaagcccta tgccttgaat ctggagaaga acttccctgt ggacacgcct      480

gatgactatg agactcaaca atggcctgag aggaaactca agcacatgcg gttccctctc      540

atgtatgaag agaattccag ggaaaacccc ttcaaacgca caaacgaaat agtagaagaa      600

cagtacacac cccaaagtct tgctaccctg gagtctgtgt tccaagagct tgggaaactg      660

acagggccaa gcaaccagaa gcgtgagagg gttgacgagg aacagaagct ctacacggac      720

gatgaagatg acgtgtacaa gaccaacaac attgcctatg aagatgtggt cgggggagaa      780

gactggagtc ctatggagga gaaaatagag actcaaaccc aggaagaggt gagagacagc      840

aaagagaaca cagaaaaaaa cgaacaaatc aatgaagaga tgaaacggtc agggcacttg      900

gggctcccag atgaaggtaa ccggaaagag agcaaagacc agctctcaga ggacgcctcc      960

aaggtcatca cctacttgag aaggttagtg aatgctgtgg gcagtgggag gtcccagagt     1020

gggcaaaacg gggacagggc agccaggctt cttgagaggc cccttgattc tcagtctatt     1080

tatcagctga ttgaaatctc caggaatttg cagatacccc ctgaagactt aattgagatg     1140

ctcaaagctg gggagaaacc aaatgggttg gtggagcccg agcaggatct ggagcttgct     1200

gttgacctag atgacatccc ggaagctgac atagaccgcc cagacatgtt tcaaagtaag     1260

acgctctcca agggtgggta tcccaaggca cctggtcgag gtatgatgga ggccttgcca     1320

gatggcctca gtgttgaaga cattttaaat gttttaggga tggagaatgt agcaaatcag     1380

aagtccccat atttccccaa ccaatacagc cgagacaagg ctctgctgag gcttccttat     1440

ggtcctggga aatctagagc caaccagatt cccaaagtag cctggatccc agacgttgaa     1500

agcagacaag ccccctatga caatctgaat gataaggacc aagaattggg agagtactta     1560

gccaggatgc tagttaagta ccctgagctc atgaatacca accagctgaa gagagtgccc     1620

agcccaggct cctcagaaga tgacctccaa gaagaagagc agctcgagca ggccatcaag     1680

gagcatctgg gtcaaggaag ctcccaggaa atggagaaac tggccaaggt gagcaaaagg     1740

atccctgcag gatccctgaa gaatgaggat accccaaata gacagtacct ggatgaagat     1800

atgctcctga aagtgctaga gtatctcaat caagaacagg cagagcaggg aagggaacat     1860

cttgccaaac gggccatgga aaacatgtaa acagctttaa tgcccaattt cccttctttt     1920

ccccaagtga atcccctccc tttctcttaa gtgtgttaat ctctatcctg ttaacactgt     1980

aatatcttta agtgatgtac aagcagatga ctccagatag ttttggggat ctgctttact     2040

tattctgagc tgttatgttg tgtatggatg tgtataaatg ttatgactct cagatttaaa     2100

aaatatgtcc tttattcaag aaagatatct atgatagtgt tgactaatgt atccaatggt     2160

catggtattg acaatgctca catatgatga agagtatcct ataattatct tggaagtttt     2220

taacatttat tgaattattt tgttactgtc tgtagtgttt tgtggagttc tggagcaaaa     2280

tcaataaagc a                                                          2291


<210>  38
<211>  2568
<212>  DNA
<213>  Pan troglodytes

<400>  38
ataaagtgat tattttctct tggttctttg aaaaacctcg cttgtgctgg ggtttgtggc       60

tgaacccggt gacgtcagtg tggcagtgcg gagtcaggcg cagcggctcc ctataagcag      120

aggagctgtc cgtgtgctga aacggcccga gaagctcgcc cggagaacgg ggaggaatat      180

gctgtggagc tcctctgcca tataaacaaa aagaggaaat ctttcagaca tggctgaagc      240

aaagacccac tggcttggag cagccctgtc tcttatccct ttaattttcc tcatctctgg      300

ggctgaagca gcttcatttc agagaaacca gctgcttcag aaagaaccag acctcaggtt      360

ggaaaatgtc caaaagtttc ccagtcctga aatgatcagg gctttggagt acatagaaaa      420

gctccgacaa caggctcata aggaagaaag cagcccagat tataatccct accaaggtgt      480

ctctgtcccc cttcagcaaa aagaaaatgg cgatgaaagt cacttgcccg agagggattc      540

actgagtgaa gaagactgga tgagaataat actcgaagct ttgagacagg ctgaaaatga      600

gcctcagtct gcaccaaaag aaaataagcc ctatgccttg aattcagaaa agaactttcc      660

aatggacatg agtgatgatt atgagacaca gcagtggcca gaaagaaagc ttaagcacat      720

gcaattccct cctatgtatg aagagaattc cagggataac ccctttaaac gcacaaatga      780

aatagtggag gaacaatata ctcctcaaag ccttgctaca ttggaatctg tcttccaaga      840

gctggggaaa ctgacaggac caaacaacca gaaacgtgag aggatggatg aggagcaaaa      900

actttatacg gatgatgatg atatctacaa ggctaataac attgcctatg aagatgtggt      960

ggggggagaa gattggaacc cagtagagga gaaaatagag agtcaaaccc aggaagaggt     1020

gagagacagc aaagagaata tagaaaaaaa tgaacaaatc aatgatgaga tgaaacgctc     1080

agggcagctt ggcatccagg aagaagatct tcggaaagag agtaaagacc aactctcaga     1140

tgatgtctcc aaagtaattg cctatttgaa aaggttagta aatgctgcag gaagtgggag     1200

gttacagaat gggcaaaatg gggaaagggc caccaggctt tttgagaaac ctcttgattc     1260

tcagtctatt tatcagctga ttgaaatctc aaggaattta cagatacccc cagaagactt     1320

aattgagatg ctcaaaactg gggagaagcc gaatggatca gtggaaccgg agcgggagct     1380

tgaccttcct gttgacctag atgacatctc agaggctgac ttagaccatc cagacctgtt     1440

ccaaaataag atgctctcca agagtggcta ccctaaaaca cctggtcgtg ctgggactga     1500

ggccctacca gacgggctca gtgttgagga tattttaaat cttttaggga tggagagtgc     1560

agcaaatcag aaaacttcgt attttcccaa tccatataac caggagaaag ttctgccaag     1620

gctcccttat ggtcctggaa gatctagatc gaaccagctt cccaaagctg cctggattcc     1680

atatgttgaa aacagacaga tggcatatga aaacctgaac gacaaggatc aagaattagg     1740

tgagtacttg gccaggatgc tagttaaata ccctgagatc attaattcaa accaagtgaa     1800

gcgagttcct ggtcaaggct catctgaaga tgacctacag gaagaggaac aaattgagca     1860

ggccatcaaa gagcatttga atcaaggcag ctctcaggag actgacaagc tggccccggt     1920

gagcaaaagg ttccctgtgg ggcccccgaa gaatgatgat accccaaata ggcagtactt     1980

ggatgaagat ctgttaatga aagtgctgga atacctcaac caagaaaagg cagaaaaggg     2040

aagggagcat attgctaaga gagcaatgga aaatatgtaa gctgctttca ttaattaccc     2100

tactttcatt cctcccaccc caagcaaatc ccaacatttc tctttagtgt gttgacttct     2160

atcctgttaa cactgtaata tctttaaatg atgtacaggc agatgaaacc aggtcactgg     2220

ggagtctgct tcatttcctc tgagctgtta tcttgtgtat ggatacgtgt aaatgttatg     2280

actccttgat aaaaaattta ttatgtccat tattcaagaa agatatctat gactgtgttt     2340

aatagtgtat ctaatggctg tggcattgtt gatgctcaca tatgataaaa agtgtcctat     2400

aattctattg aaagttttta atatttattg aattattttg ttactgtctg tagtgttttg     2460

tggagtactg gaccaaaaaa ataaagcatt ataaatatat agttttattt ataaggcctt     2520

ttctattgtg tgttttactg ttgattaata aatgttattt ctggacaa                  2568


<210>  39
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  39

Leu Leu Ile Ile Leu Arg Arg Arg Ile Arg Lys Gln Ala His Ala His 
1               5                   10                  15      


Ser Lys 
        


<210>  40
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  40

Arg Arg Leu Ser Tyr Ser Arg Arg Arg Phe 
1               5                   10  


<210>  41
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  41

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  42
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  42

Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  43
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  43

Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Pro Gly Thr Pro Cys Asp 
1               5                   10                  15      


Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Asn Gly 
            20                  25                  


<210>  44
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  44

Thr Phe Phe Tyr Gly Gly Ser Arg Gly Lys Arg Asn Asn Phe Lys Thr 
1               5                   10                  15      


Glu Glu Tyr 
            


<210>  45
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  45

Tyr Glu Glu Thr Lys Phe Asn Asn Arg Lys Gly Arg Ser Gly Gly Tyr 
1               5                   10                  15      


Phe Phe Thr 
            


<210>  46
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  46

Leu Arg Lys Leu Arg Lys Arg Leu Leu Arg 
1               5                   10  


<210>  47
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  47

Cys Gly His Lys Ala Lys Gly Pro Arg Lys 
1               5                   10  


<210>  48
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  cyclic peptide

<400>  48

Arg Gly Asp Phe Lys 
1               5   


<210>  49
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  49

Phe Lys Glu Ser Trp Arg Glu Ala Arg Gly Thr Arg Ile Glu Arg Gly 
1               5                   10                  15      


<210>  50
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  50

Gly Arg Glu Ile Arg Thr Gly Arg Ala Glu Arg Trp Ser Glu Lys Phe 
1               5                   10                  15      


<210>  51
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide


<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  O-beta-glucoside

<400>  51

Tyr Gly Gly Phe Leu Gly Gly Tyr Thr Gly Phe Leu Ser 
1               5                   10              


<210>  52
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  monosaccharide

<400>  52

Gly Phe Thr Gly Phe Leu Ser 
1               5           


<210>  53
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  53

His Gly Leu Ala Ser Thr Leu Thr Arg Trp Ala His Tyr Asn Ala Leu 
1               5                   10                  15      


Ile Arg Ala Phe Gly Gly Gly 
            20              


<210>  54
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  54

Gly Ser His 
1           


<210>  55
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  55

Leu Pro Phe Phe Asp 
1               5   


<210>  56
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  cyclized peptide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  diaminopropionic acid

<400>  56

Lys Ala Pro Glu Thr Ala Leu Asp 
1               5               


<210>  57
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  57

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  58
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  58

Lys Ser Val Arg Thr Trp Asn Glu Ile Ile Pro Ser Lys Gly Cys Leu 
1               5                   10                  15      


Arg Val Gly Gly Arg Cys His Pro His Val Asn Gly Gly Gly Arg Arg 
            20                  25                  30          


Arg Arg Arg Arg Arg Arg Arg 
        35                  


<210>  59
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  59

Tyr Thr Trp Met Pro Glu Asn Pro Arg Pro Gly Thr Pro Cys Asp Ile 
1               5                   10                  15      


Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Asn Gly Gly Gly Gly Gly 
            20                  25                  30          


Gly Cys 
        


<210>  60
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  60

Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Met Ala Arg Lys Cys 
1               5                   10                  15      


Asp Asp Cys Cys Gly Gly Lys Gly Arg Gly Lys Cys Tyr Gly Pro Gln 
            20                  25                  30          


Cys Leu Cys Arg 
        35      


<210>  61
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  61

His Ala Ile Tyr Pro Arg His 
1               5           


<210>  62
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  62

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln Gly Trp Cys 
1               5                   10                  15      


<210>  63
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  63

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  64
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  64

Arg Arg Arg Gln Arg Arg Lys Lys Arg Gly Tyr 
1               5                   10      


<210>  65
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  65

Thr Gly Asn Tyr Lys Ala Leu His Pro His Asn Gly 
1               5                   10          


<210>  66
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  66

Thr His Arg Pro Pro Met Trp Ser Pro Val Trp Pro 
1               5                   10          


<210>  67
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  67

Pro Trp Val Pro Ser Trp Met Pro Pro Arg His Thr 
1               5                   10          


<210>  68
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide


<220>
<221>  misc_feature
<222>  (2)..(8)
<223>  cyclized peptide

<400>  68

Cys Met Pro Arg Leu Arg Gly Cys 
1               5               


