
                                SEQUENCE LISTING

<110> ViiV Healthcare Comapny

<120> COMBINATION THERAPY
  

<130> PU66989P

<140> Not Yet Assigned    
<141>     -  -    

<150> 63/122031           
<151> 2020-12-07  

<160> 22

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> An amino acid sequence of the VH of the N6 mAb

<400> 1
Arg Ala His Leu Val Gln Ser Gly Thr Ala Met Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Arg Val Ser Cys Gln Thr Ser Gly Tyr Thr Phe Thr Ala His
            20                  25                  30          
Ile Leu Phe Trp Phe Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val
        35                  40                  45              
Gly Trp Ile Lys Pro Gln Tyr Gly Ala Val Asn Phe Gly Gly Gly Phe
    50                  55                  60                  
Arg Asp Arg Val Thr Leu Thr Arg Asp Val Tyr Arg Glu Ile Ala Tyr
65                  70                  75                  80  
Met Asp Ile Arg Gly Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Arg Ser Tyr Gly Asp Ser Ser Trp Ala Leu Asp Ala Trp
            100                 105                 110         
Gly Gln Gly Thr Thr Val Val Val Ser Ala
        115                 120         


<210> 2
<211> 103
<212> PRT
<213> Artificial Sequence

<220> 
<223> An amino acid sequence of the VL of the N6 mAb

<400> 2
Tyr Ile His Val Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ile Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Asn Cys Gln Thr Ser Gln Gly Val Gly Ser Asp
            20                  25                  30          
Leu His Trp Tyr Gln His Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile
        35                  40                  45              
His His Thr Ser Ser Val Glu Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Phe His Thr Ser Phe Asn Leu Thr Ile Ser Asp Leu Gln Ala
65                  70                  75                  80  
Asp Asp Ile Ala Thr Tyr Tyr Cys Gln Val Leu Gln Phe Phe Gly Arg
                85                  90                  95      
Gly Ser Arg Leu His Ile Lys
            100             


<210> 3
<211> 366
<212> DNA
<213> Artificial Sequence

<220> 
<223> A nucleic acid sequence encoding the VH of the N6
      mAb

<400> 3
cgagcgcacc tggtacaatc agggactgcg atgaagaaac cgggggcctc agtaagagtc 60
tcctgccaga cctctggata cacctttacc gcccacatat tattttggtt ccgacaggcc 120
cccgggcgag gacttgagtg ggtggggtgg atcaagccac aatatggggc cgtgaatttt 180
ggtggtggtt ttcgggacag ggtcacattg actcgagacg tatatagaga gattgcgtac 240
atggacatca gaggccttaa acctgacgac acggccgtct attactgtgc gagagaccgt 300
tcctatggcg actcctcttg ggccttagat gcctggggac agggaacgac ggtcgtcgtc 360
tccgcg                                                            366

<210> 4
<211> 309
<212> DNA
<213> Artificial Sequence

<220> 
<223> A nucleic acid sequence encoding the VL of the N6
      mAb

<400> 4
tacatccacg tgacccagtc tccgtcctcc ctgtctgtgt ctattggaga cagagtcacc 60
atcaattgcc agacgagtca gggtgttggc agtgacctac attggtatca acacaaaccg 120
gggagagccc ctaaactctt gatccaccat acctcttctg tggaagacgg tgtcccctca 180
agattcagcg gctctggatt tcacacatct tttaatctga ccatcagcga cctacaggct 240
gacgacattg ccacatatta ctgtcaagtt ttacaatttt tcggccgagg gagtcgactc 300
catattaaa                                                         309

<210> 5
<211> 452
<212> PRT
<213> Artificial Sequence

<220> 
<223> A heavy chain sequence including the N6 VH

<400> 5
Arg Ala His Leu Val Gln Ser Gly Thr Ala Met Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Arg Val Ser Cys Gln Thr Ser Gly Tyr Thr Phe Thr Ala His
            20                  25                  30          
Ile Leu Phe Trp Phe Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val
        35                  40                  45              
Gly Trp Ile Lys Pro Gln Tyr Gly Ala Val Asn Phe Gly Gly Gly Phe
    50                  55                  60                  
Arg Asp Arg Val Thr Leu Thr Arg Asp Val Tyr Arg Glu Ile Ala Tyr
65                  70                  75                  80  
Met Asp Ile Arg Gly Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Arg Ser Tyr Gly Asp Ser Ser Trp Ala Leu Asp Ala Trp
            100                 105                 110         
Gly Gln Gly Thr Thr Val Val Val Ser Ala Ala Ser Thr Lys Gly Pro
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser
    210                 215                 220                 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu
225                 230                 235                 240 
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
                245                 250                 255     
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
            260                 265                 270         
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
        275                 280                 285             
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
    290                 295                 300                 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
305                 310                 315                 320 
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
                325                 330                 335     
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
            340                 345                 350         
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val
        355                 360                 365             
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
    370                 375                 380                 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
385                 390                 395                 400 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
                405                 410                 415     
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
            420                 425                 430         
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
        435                 440                 445             
Ser Pro Gly Lys
    450         


<210> 6
<211> 1356
<212> DNA
<213> Artificial Sequence

<220> 
<223> A nucleic acid sequence encoding a heavy chain
      including the N6 VH

<400> 6
cgagcgcacc tggtacaatc agggactgcg atgaagaaac cgggggcctc agtaagagtc 60
tcctgccaga cctctggata cacctttacc gcccacatat tattttggtt ccgacaggcc 120
cccgggcgag gacttgagtg ggtggggtgg atcaagccac aatatggggc cgtgaatttt 180
ggtggtggtt ttcgggacag ggtcacattg actcgagacg tatatagaga gattgcgtac 240
atggacatca gaggccttaa acctgacgac acggccgtct attactgtgc gagagaccgt 300
tcctatggcg actcctcttg ggccttagat gcctggggac agggaacgac ggtcgtcgtc 360
tccgcggcgt cgaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc 420
tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg 480
gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag 540
tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc 600
cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt 660
gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg 720
gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg 780
acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc 840
aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag 900
tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat 960
ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc 1020
atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg 1080
gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc 1140
gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct 1200
cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc 1260
aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac 1320
tacacgcaga agagcctctc cctgtctccg ggtaaa                           1356

<210> 7
<211> 210
<212> PRT
<213> Artificial Sequence

<220> 
<223> A light chain sequence including the N6 VL

<400> 7
Tyr Ile His Val Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ile Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Asn Cys Gln Thr Ser Gln Gly Val Gly Ser Asp
            20                  25                  30          
Leu His Trp Tyr Gln His Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile
        35                  40                  45              
His His Thr Ser Ser Val Glu Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Phe His Thr Ser Phe Asn Leu Thr Ile Ser Asp Leu Gln Ala
65                  70                  75                  80  
Asp Asp Ile Ala Thr Tyr Tyr Cys Gln Val Leu Gln Phe Phe Gly Arg
                85                  90                  95      
Gly Ser Arg Leu His Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe
            100                 105                 110         
Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val
        115                 120                 125             
Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp
    130                 135                 140                 
Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr
145                 150                 155                 160 
Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr
                165                 170                 175     
Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val
            180                 185                 190         
Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly
        195                 200                 205             
Glu Cys
    210 


<210> 8
<211> 630
<212> DNA
<213> Artificial Sequence

<220> 
<223> A nucleic acid sequence encoding a light chain
      including the N6 VH

<400> 8
tacatccacg tgacccagtc tccgtcctcc ctgtctgtgt ctattggaga cagagtcacc 60
atcaattgcc agacgagtca gggtgttggc agtgacctac attggtatca acacaaaccg 120
gggagagccc ctaaactctt gatccaccat acctcttctg tggaagacgg tgtcccctca 180
agattcagcg gctctggatt tcacacatct tttaatctga ccatcagcga cctacaggct 240
gacgacattg ccacatatta ctgtcaagtt ttacaatttt tcggccgagg gagtcgactc 300
catattaaac gtacggtggc tgcaccatct gtcttcatct tcccgccatc tgatgagcag 360
ttgaaatctg gaactgcctc tgttgtgtgc ctgctgaata acttctaccc cagagaagcc 420
aaagtgcagt ggaaggtgga caacgccctg cagagcggaa acagccagga aagcgtgaca 480
gagcaggatt ccaaggattc cacatacagc ctgagcagca cactgacact gtccaaggcc 540
gactacgaga agcacaaggt gtacgcctgc gaagtgacac accagggact gtcctcccct 600
gtgacaaaga gcttcaacag aggagaatgc                                  630

<210> 9
<211> 452
<212> PRT
<213> Artificial Sequence

<220> 
<223> A heavy chain sequence including the N6 VH as
      isolated from a human donor, which include
      polymorphism compared to SEQ ID NO: 5

<400> 9
Arg Ala His Leu Val Gln Ser Gly Thr Ala Met Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Arg Val Ser Cys Gln Thr Ser Gly Tyr Thr Phe Thr Ala His
            20                  25                  30          
Ile Leu Phe Trp Phe Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val
        35                  40                  45              
Gly Trp Ile Lys Pro Gln Tyr Gly Ala Val Asn Phe Gly Gly Gly Phe
    50                  55                  60                  
Arg Asp Arg Val Thr Leu Thr Arg Asp Val Tyr Arg Glu Ile Ala Tyr
65                  70                  75                  80  
Met Asp Ile Arg Gly Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Arg Ser Tyr Gly Asp Ser Ser Trp Ala Leu Asp Ala Trp
            100                 105                 110         
Gly Gln Gly Thr Thr Val Val Val Ser Ala Ala Ser Thr Lys Gly Pro
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser
    210                 215                 220                 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu
225                 230                 235                 240 
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
                245                 250                 255     
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
            260                 265                 270         
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
        275                 280                 285             
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
    290                 295                 300                 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
305                 310                 315                 320 
Gly Glu Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
                325                 330                 335     
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
            340                 345                 350         
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val
        355                 360                 365             
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
    370                 375                 380                 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
385                 390                 395                 400 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
                405                 410                 415     
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
            420                 425                 430         
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
        435                 440                 445             
Ser Pro Gly Lys
    450         


<210> 10
<211> 1356
<212> DNA
<213> Artificial Sequence

<220> 
<223> A sequence of the nucleic acid molecule encoding
      the N6 VH as isolated from a human donor

<400> 10
cgagcgcacc tggtacaatc agggactgcg atgaagaaac cgggggcctc agtaagagtc 60
tcctgccaga cctctggata cacctttacc gcccacatat tattttggtt ccgacaggcc 120
cccgggcgag gacttgagtg ggtggggtgg atcaagccac aatatggggc cgtgaatttt 180
ggtggtggtt ttcgggacag ggtcacattg actcgagacg tatatagaga gattgcgtac 240
atggacatca gaggccttaa acctgacgac acggccgtct attactgtgc gagagaccgt 300
tcctatggcg actcctcttg ggccttagat gcctggggac agggaacgac ggtcgtcgtc 360
tccgcggcct ccaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc 420
tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg 480
gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag 540
tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc 600
cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagagagtt 660
gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg 720
gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg 780
acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc 840
aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag 900
tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat 960
ggcgaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc 1020
atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg 1080
gaggagatga ccaagaacca ggtcagcctg acctgccttg tcaaaggctt ctatcccagc 1140
gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct 1200
cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc 1260
aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac 1320
tacacgcaga agagcctctc cctgtctccg ggtaaa                           1356

<210> 11
<211> 366
<212> DNA
<213> Artificial Sequence

<220> 
<223> A nucleotide sequence encoding the N6 I1 VH
      intermediate

<400> 11
cgagggcact tggtgcagtc agggactgag gtgaagaaac cgggggcctc agtgagagtc 60
tcctgcgaga cttctggata caccttcacc gcctacattt tacattggtt ccgacaggcc 120
cccggacgag ggcttgagtg gatggggtgg atcaagccaa aatatggagc cgtcaattat 180
gctcatgcat ttcagggcag ggtcaccctg accagagaca tatatagaga cactgcatac 240
atggacttga gtggcctaag attcgacgac acggccgtct attactgtgc gagagatcgc 300
gtttatgacg attcgtcttg gcaattggat ccctggggcc agggaacttc ggtcatcgtc 360
tcctca                                                            366

<210> 12
<211> 366
<212> DNA
<213> Artificial Sequence

<220> 
<223> A nucleotide sequence encoding the N6 I2 VH
      intermediate

<400> 12
cgagggcact tggtgcagtc agggactgag gtgaagaaac cgggggcctc agtgagagtc 60
tcctgcgaga cttctggata caccttcacc gcccacattt tacattggtt ccgacaggcc 120
cccggacgag ggcttgagtg gatggggtgg atcaagccaa aatatggagc cgtcaattat 180
gctcatgcat ttcagggcag ggtcaccctg accagagaca tatatagaga cactgcatac 240
atggacttga gtggcctaag attcgacgac acggccgtct attactgtgc gagagatcgc 300
gtttatgacg attcgtcttg gcaattggat ccctggggcc agggaacttc ggtcatcgtc 360
tcctca                                                            366

<210> 13
<211> 366
<212> DNA
<213> Artificial Sequence

<220> 
<223> A nucleotide sequence encoding the N6 I3 VH
      intermediate.

<400> 13
cgagcgcact tggtgcagtc agggactgcg gtgaagaaac cgggggcctc agtgagagtc 60
tcctgcgaga cttctggata caccttcacc gcccacattt tatattggtt ccgacaggcc 120
cccggacgag ggcttgagtg ggtggggtgg atcaagccac aatatggggc cgtgaatttt 180
ggtggtggtt ttcggggcag ggtcaccctg accagagaca tatatagaga cactgcatac 240
atggacatca gtggcctaag attcgacgac acggccgtct attactgtgc gagagatcgc 300
tcctatgacg actcctcttg ggccttagat gcctggggac agggaacgac ggtcgtcgtc 360
tccgcg                                                            366

<210> 14
<211> 366
<212> DNA
<213> Artificial Sequence

<220> 
<223> A nucleotide sequence encoding the N6 I4 VH
      intermediate.

<400> 14
cgagcgcacc tggtacaatc agggactgcg atgaagaaac cgggggcctc agtaagagtc 60
tcctgccaga cctctggata cacctttacc gcccacatat tattttggtt ccgacaggcc 120
cccgggcgag gacttgagtg ggtggggtgg atcaagccac aatatggggc cgtgaatttt 180
ggtggtggtt ttcgggacag ggtcacattg actcgagaca tatatagaga gattgcgtac 240
atggacatca gaggccttaa acttgacgac acggccgtct attactgtgc gagagaccgt 300
tcctatggcg actcctcttg ggccttagat gcctggggac agggaacgac ggtcgtcgtc 360
tccgcg                                                            366

<210> 15
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> An amino acid sequence of N6 CDRH1

<400> 15
Ala His Ile Leu Phe
 1               5  


<210> 16
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> An amino acid sequence of N6 CDRH2

<400> 16
Trp Ile Lys Pro Gln Tyr Gly Ala Val Asn Phe Gly Gly Gly Phe Arg
 1               5                  10                  15      
Asp
    


<210> 17
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> An amino acid sequence of N6 CDRH3

<400> 17
Asp Arg Ser Tyr Gly Asp Ser Ser Trp Ala Leu Asp Ala
 1               5                  10              


<210> 18
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> An amino acid sequence of N6 CDRL1

<400> 18
Gln Thr Ser Gln Gly Val Gly Ser Asp Leu His
 1               5                  10      


<210> 19
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> An amino acid sequence of N6 CDRL2

<400> 19
His Thr Ser Ser Val Glu Asp
 1               5          


<210> 20
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> An amino acid sequence of N6 CDRL3

<400> 20
Gln Val Leu Gln Phe
 1               5  


<210> 21
<211> 471
<212> PRT
<213> Artificial Sequence

<220> 
<223> An amino acid sequence of the N6-LS heavy chain

<400> 21
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly
 1               5                  10                  15      
Val His Ser Arg Ala His Leu Val Gln Ser Gly Thr Ala Met Lys Lys
            20                  25                  30          
Pro Gly Ala Ser Val Arg Val Ser Cys Gln Thr Ser Gly Tyr Thr Phe
        35                  40                  45              
Thr Ala His Ile Leu Phe Trp Phe Arg Gln Ala Pro Gly Arg Gly Leu
    50                  55                  60                  
Glu Trp Val Gly Trp Ile Lys Pro Gln Tyr Gly Ala Val Asn Phe Gly
65                  70                  75                  80  
Gly Gly Phe Arg Asp Arg Val Thr Leu Thr Arg Asp Val Tyr Arg Glu
                85                  90                  95      
Ile Ala Tyr Met Asp Ile Arg Gly Leu Lys Pro Asp Asp Thr Ala Val
            100                 105                 110         
Tyr Tyr Cys Ala Arg Asp Arg Ser Tyr Gly Asp Ser Ser Trp Ala Leu
        115                 120                 125             
Asp Ala Trp Gly Gln Gly Thr Thr Val Val Val Ser Ala Ala Ser Thr
    130                 135                 140                 
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
145                 150                 155                 160 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
                165                 170                 175     
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
            180                 185                 190         
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
        195                 200                 205             
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
    210                 215                 220                 
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
225                 230                 235                 240 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
                245                 250                 255     
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
            260                 265                 270         
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
        275                 280                 285             
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
    290                 295                 300                 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
305                 310                 315                 320 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
                325                 330                 335     
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
            340                 345                 350         
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
        355                 360                 365             
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
    370                 375                 380                 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
385                 390                 395                 400 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
                405                 410                 415     
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
            420                 425                 430         
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
        435                 440                 445             
Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser
    450                 455                 460                 
Leu Ser Leu Ser Pro Gly Lys
465                 470     


<210> 22
<211> 229
<212> PRT
<213> Artificial Sequence

<220> 
<223> An amino acid sequence of the N6-LS light chain

<400> 22
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly
 1               5                  10                  15      
Val His Ser Tyr Ile His Val Thr Gln Ser Pro Ser Ser Leu Ser Val
            20                  25                  30          
Ser Ile Gly Asp Arg Val Thr Ile Asn Cys Gln Thr Ser Gln Gly Val
        35                  40                  45              
Gly Ser Asp Leu His Trp Tyr Gln His Lys Pro Gly Arg Ala Pro Lys
    50                  55                  60                  
Leu Leu Ile His His Thr Ser Ser Val Glu Asp Gly Val Pro Ser Arg
65                  70                  75                  80  
Phe Ser Gly Ser Gly Phe His Thr Ser Phe Asn Leu Thr Ile Ser Asp
                85                  90                  95      
Leu Gln Ala Asp Asp Ile Ala Thr Tyr Tyr Cys Gln Val Leu Gln Phe
            100                 105                 110         
Phe Gly Arg Gly Ser Arg Leu His Ile Lys Arg Thr Val Ala Ala Pro
        115                 120                 125             
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr
    130                 135                 140                 
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys
145                 150                 155                 160 
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
                165                 170                 175     
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser
            180                 185                 190         
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala
        195                 200                 205             
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe
    210                 215                 220                 
Asn Arg Gly Glu Cys
225                 

