<110>    Medicinal Bioconvergence Research Center

<120>    Novel fragmented cysteinyl-tRNA synthetase peptide with
         immune-enhancing activity and use thereof

<130>    OP21-0144/PCT

<150>    KR 10-2020-0172565
<151>    2020-12-10

<160>    4

<170>    KoPatentIn 3.0

<210>    1
<211>    748
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Full-length CRS


<400>    1
Met Ala Asp Ser Ser Gly Gln Gln Gly Lys Gly Arg Arg Val Gln Pro
  1               5                  10                  15 

Gln Trp Ser Pro Pro Ala Gly Thr Gln Pro Cys Arg Leu His Leu Tyr
             20                  25                  30 

Asn Ser Leu Thr Arg Asn Lys Glu Val Phe Ile Pro Gln Asp Gly Lys
         35                  40                  45 

Lys Val Thr Trp Tyr Cys Cys Gly Pro Thr Val Tyr Asp Ala Ser His
     50                  55                  60 

Met Gly His Ala Arg Ser Tyr Ile Ser Phe Asp Ile Leu Arg Arg Val
 65                  70                  75                  80 

Leu Lys Asp Tyr Phe Lys Phe Asp Val Phe Tyr Cys Met Asn Ile Thr
                 85                  90                  95 

Asp Ile Asp Asp Lys Ile Ile Lys Arg Ala Arg Gln Asn His Leu Phe
            100                 105                 110 

Glu Gln Tyr Arg Glu Lys Arg Pro Glu Ala Ala Gln Leu Leu Glu Asp
        115                 120                 125 

Val Gln Ala Ala Leu Lys Pro Phe Ser Val Lys Leu Asn Glu Thr Thr
    130                 135                 140 

Asp Pro Asp Lys Lys Gln Met Leu Glu Arg Ile Gln His Ala Val Gln
145                 150                 155                 160 

Leu Ala Thr Glu Pro Leu Glu Lys Ala Val Gln Ser Arg Leu Thr Gly
                165                 170                 175 

Glu Glu Val Asn Ser Cys Val Glu Val Leu Leu Glu Glu Ala Lys Asp
            180                 185                 190 

Leu Leu Ser Asp Trp Leu Asp Ser Thr Leu Gly Cys Asp Val Thr Asp
        195                 200                 205 

Asn Ser Ile Phe Ser Lys Leu Pro Lys Phe Trp Glu Gly Asp Phe His
    210                 215                 220 

Arg Asp Met Glu Ala Leu Asn Val Leu Pro Pro Asp Val Leu Thr Arg
225                 230                 235                 240 

Val Ser Glu Tyr Val Pro Glu Ile Val Asn Phe Val Gln Lys Ile Val
                245                 250                 255 

Asp Asn Gly Tyr Gly Tyr Val Ser Asn Gly Ser Val Tyr Phe Asp Thr
            260                 265                 270 

Ala Lys Phe Ala Ser Ser Glu Lys His Ser Tyr Gly Lys Leu Val Pro
        275                 280                 285 

Glu Ala Val Gly Asp Gln Lys Ala Leu Gln Glu Gly Glu Gly Asp Leu
    290                 295                 300 

Ser Ile Ser Ala Asp Arg Leu Ser Glu Lys Arg Ser Pro Asn Asp Phe
305                 310                 315                 320 

Ala Leu Trp Lys Ala Ser Lys Pro Gly Glu Pro Ser Trp Pro Cys Pro
                325                 330                 335 

Trp Gly Lys Gly Arg Pro Gly Trp His Ile Glu Cys Ser Ala Met Ala
            340                 345                 350 

Gly Thr Leu Leu Gly Ala Ser Met Asp Ile His Gly Gly Gly Phe Asp
        355                 360                 365 

Leu Arg Phe Pro His His Asp Asn Glu Leu Ala Gln Ser Glu Ala Tyr
    370                 375                 380 

Phe Glu Asn Asp Cys Trp Val Arg Tyr Phe Leu His Thr Gly His Leu
385                 390                 395                 400 

Thr Ile Ala Gly Cys Lys Met Ser Lys Ser Leu Lys Asn Phe Ile Thr
                405                 410                 415 

Ile Lys Asp Ala Leu Lys Lys His Ser Ala Arg Gln Leu Arg Leu Ala
            420                 425                 430 

Phe Leu Met His Ser Trp Lys Asp Thr Leu Asp Tyr Ser Ser Asn Thr
        435                 440                 445 

Met Glu Ser Ala Leu Gln Tyr Glu Lys Phe Leu Asn Glu Phe Phe Leu
    450                 455                 460 

Asn Val Lys Asp Ile Leu Arg Ala Pro Val Asp Ile Thr Gly Gln Phe
465                 470                 475                 480 

Glu Lys Trp Gly Glu Glu Glu Ala Glu Leu Asn Lys Asn Phe Tyr Asp
                485                 490                 495 

Lys Lys Thr Ala Ile His Lys Ala Leu Cys Asp Asn Val Asp Thr Arg
            500                 505                 510 

Thr Val Met Glu Glu Met Arg Ala Leu Val Ser Gln Cys Asn Leu Tyr
        515                 520                 525 

Met Ala Ala Arg Lys Ala Val Arg Lys Arg Pro Asn Gln Ala Leu Leu
    530                 535                 540 

Glu Asn Ile Ala Leu Tyr Leu Thr His Met Leu Lys Ile Phe Gly Ala
545                 550                 555                 560 

Val Glu Glu Asp Ser Ser Leu Gly Phe Pro Val Gly Gly Pro Gly Thr
                565                 570                 575 

Ser Leu Ser Leu Glu Ala Thr Val Met Pro Tyr Leu Gln Val Leu Ser
            580                 585                 590 

Glu Phe Arg Glu Gly Val Arg Lys Ile Ala Arg Glu Gln Lys Val Pro
        595                 600                 605 

Glu Ile Leu Gln Leu Ser Asp Ala Leu Arg Asp Asn Ile Leu Pro Glu
    610                 615                 620 

Leu Gly Val Arg Phe Glu Asp His Glu Gly Leu Pro Thr Val Val Lys
625                 630                 635                 640 

Leu Val Asp Arg Asn Thr Leu Leu Lys Glu Arg Glu Glu Lys Arg Arg
                645                 650                 655 

Val Glu Glu Glu Lys Arg Lys Lys Lys Glu Glu Ala Ala Arg Arg Lys
            660                 665                 670 

Gln Glu Gln Glu Ala Ala Lys Leu Ala Lys Met Lys Ile Pro Pro Ser
        675                 680                 685 

Glu Met Phe Leu Ser Glu Thr Asp Lys Tyr Ser Lys Phe Asp Glu Asn
    690                 695                 700 

Gly Leu Pro Thr His Asp Met Glu Gly Lys Glu Leu Ser Lys Gly Gln
705                 710                 715                 720 

Ala Lys Lys Leu Lys Lys Leu Phe Glu Ala Gln Glu Lys Leu Tyr Lys
                725                 730                 735 

Glu Tyr Leu Gln Met Ala Gln Asn Gly Ser Phe Gln
            740                 745            


<210>    2
<211>    105
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    CRS (99-200): C-VAX


<400>    2
Gly Ala Met Asp Asp Lys Ile Ile Lys Arg Ala Arg Gln Asn His Leu
  1               5                  10                  15 

Phe Glu Gln Tyr Arg Glu Lys Arg Pro Glu Ala Ala Gln Leu Leu Glu
             20                  25                  30 

Asp Val Gln Ala Ala Leu Lys Pro Phe Ser Val Lys Leu Asn Glu Thr
         35                  40                  45 

Thr Asp Pro Asp Lys Lys Gln Met Leu Glu Arg Ile Gln His Ala Val
     50                  55                  60 

Gln Leu Ala Thr Glu Pro Leu Glu Lys Ala Val Gln Ser Arg Leu Thr
 65                  70                  75                  80 

Gly Glu Glu Val Asn Ser Ser Val Glu Val Leu Leu Glu Glu Ala Lys
                 85                  90                  95 

Asp Leu Leu Ser Asp Trp Leu Asp Ser
            100                 105


<210>    3
<211>    105
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    CRS (99-200): UNE-C1-4H


<400>    3
Gly Ala Met Asp Asp Lys Ile Ile Lys Arg Ala Arg Gln Asn His Leu
  1               5                  10                  15 

Phe Glu Gln Tyr Arg Glu Lys Arg Pro Glu Ala Ala Gln Leu Leu Glu
             20                  25                  30 

Asp Val Gln Ala Ala Leu Lys Pro Phe Ser Val Lys Leu Asn Glu Thr
         35                  40                  45 

Thr Asp Pro Asp Lys Lys Gln Met Leu Glu Arg Ile Gln His Ala Val
     50                  55                  60 

Gln Leu Ala Thr Glu Pro Leu Glu Lys Ala Val Gln Ser Arg Leu Thr
 65                  70                  75                  80 

Gly Glu Glu Val Asn Ser Cys Val Glu Val Leu Leu Glu Glu Ala Lys
                 85                  90                  95 

Asp Leu Leu Ser Asp Trp Leu Asp Ser
            100                 105


<210>    4
<211>    315
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Polynucleotide encoding CRS (99-200, C-VAX)


<400>    4
ggcgccatgg atgacaagat catcaagagg gcccggcaga accacctgtt cgagcagtat         60

cgggagaaga ggcctgaagc ggcacagctc ttggaggatg ttcaggccgc cctgaagcca        120

ttttcagtaa aattaaatga gaccacggat cccgataaaa agcagatgct cgaacggatt        180

cagcacgcag tgcagcttgc cacagagcca cttgagaaag ctgtgcagtc cagactcacg        240

ggagaggaag tcaacagcag tgtggaggtg ttgctggaag aagccaagga tttgctctct        300

gactggctgg attct                                                         315
