﻿                         LISTADO DE SECUENCIAS

<110>  Instituto Politécnico Nacional
 
<120>  Composición de péptidos para inmunoterapia

<130>  PCT20/1205

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu 
    50                  55                  60                  


Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly 
65                  70                  75      


<210>  2
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu 
    50                  55                  60                  


Ser Thr Leu His Leu Val Leu Arg Leu Arg 
65                  70                  


<210>  3
<211>  1881
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Pro Tyr Ser Val Gly Phe Arg Glu Ala Asp Ala Ala Thr Ser Phe 
1               5                   10                  15      


Leu Arg Ala Ala Arg Ser Gly Asn Leu Asp Lys Ala Leu Asp His Leu 
            20                  25                  30          


Arg Asn Gly Val Asp Ile Asn Thr Cys Asn Gln Asn Gly Leu Asn Gly 
        35                  40                  45              


Leu His Leu Ala Ser Lys Glu Gly His Val Lys Met Val Val Glu Leu 
    50                  55                  60                  


Leu His Lys Glu Ile Ile Leu Glu Thr Thr Thr Lys Lys Gly Asn Thr 
65                  70                  75                  80  


Ala Leu His Ile Ala Ala Leu Ala Gly Gln Asp Glu Val Val Arg Glu 
                85                  90                  95      


Leu Val Asn Tyr Gly Ala Asn Val Asn Ala Gln Ser Gln Lys Gly Phe 
            100                 105                 110         


Thr Pro Leu Tyr Met Ala Ala Gln Glu Asn His Leu Glu Val Val Lys 
        115                 120                 125             


Phe Leu Leu Glu Asn Gly Ala Asn Gln Asn Val Ala Thr Glu Asp Gly 
    130                 135                 140                 


Phe Thr Pro Leu Ala Val Ala Leu Gln Gln Gly His Glu Asn Val Val 
145                 150                 155                 160 


Ala His Leu Ile Asn Tyr Gly Thr Lys Gly Lys Val Arg Leu Pro Ala 
                165                 170                 175     


Leu His Ile Ala Ala Arg Asn Asp Asp Thr Arg Thr Ala Ala Val Leu 
            180                 185                 190         


Leu Gln Asn Asp Pro Asn Pro Asp Val Leu Ser Lys Thr Gly Phe Thr 
        195                 200                 205             


Pro Leu His Ile Ala Ala His Tyr Glu Asn Leu Asn Val Ala Gln Leu 
    210                 215                 220                 


Leu Leu Asn Arg Gly Ala Ser Val Asn Phe Thr Pro Gln Asn Gly Ile 
225                 230                 235                 240 


Thr Pro Leu His Ile Ala Ser Arg Arg Gly Asn Val Ile Met Val Arg 
                245                 250                 255     


Leu Leu Leu Asp Arg Gly Ala Gln Ile Glu Thr Lys Thr Lys Asp Glu 
            260                 265                 270         


Leu Thr Pro Leu His Cys Ala Ala Arg Asn Gly His Val Arg Ile Ser 
        275                 280                 285             


Glu Ile Leu Leu Asp His Gly Ala Pro Ile Gln Ala Lys Thr Lys Asn 
    290                 295                 300                 


Gly Leu Ser Pro Ile His Met Ala Ala Gln Gly Asp His Leu Asp Cys 
305                 310                 315                 320 


Val Arg Leu Leu Leu Gln Tyr Asp Ala Glu Ile Asp Asp Ile Thr Leu 
                325                 330                 335     


Asp His Leu Thr Pro Leu His Val Ala Ala His Cys Gly His His Arg 
            340                 345                 350         


Val Ala Lys Val Leu Leu Asp Lys Gly Ala Lys Pro Asn Ser Arg Ala 
        355                 360                 365             


Leu Asn Gly Phe Thr Pro Leu His Ile Ala Cys Lys Lys Asn His Val 
    370                 375                 380                 


Arg Val Met Glu Leu Leu Leu Lys Thr Gly Ala Ser Ile Asp Ala Val 
385                 390                 395                 400 


Thr Glu Ser Gly Leu Thr Pro Leu His Val Ala Ser Phe Met Gly His 
                405                 410                 415     


Leu Pro Ile Val Lys Asn Leu Leu Gln Arg Gly Ala Ser Pro Asn Val 
            420                 425                 430         


Ser Asn Val Lys Val Glu Thr Pro Leu His Met Ala Ala Arg Ala Gly 
        435                 440                 445             


His Thr Glu Val Ala Lys Tyr Leu Leu Gln Asn Lys Ala Lys Val Asn 
    450                 455                 460                 


Ala Lys Ala Lys Asp Asp Gln Thr Pro Leu His Cys Ala Ala Arg Ile 
465                 470                 475                 480 


Gly His Thr Asn Met Val Lys Leu Leu Leu Glu Asn Asn Ala Asn Pro 
                485                 490                 495     


Asn Leu Ala Thr Thr Ala Gly His Thr Pro Leu His Ile Ala Ala Arg 
            500                 505                 510         


Glu Gly His Val Glu Thr Val Leu Ala Leu Leu Glu Lys Glu Ala Ser 
        515                 520                 525             


Gln Ala Cys Met Thr Lys Lys Gly Phe Thr Pro Leu His Val Ala Ala 
    530                 535                 540                 


Lys Tyr Gly Lys Val Arg Val Ala Glu Leu Leu Leu Glu Arg Asp Ala 
545                 550                 555                 560 


His Pro Asn Ala Ala Gly Lys Asn Gly Leu Thr Pro Leu His Val Ala 
                565                 570                 575     


Val His His Asn Asn Leu Asp Ile Val Lys Leu Leu Leu Pro Arg Gly 
            580                 585                 590         


Gly Ser Pro His Ser Pro Ala Trp Asn Gly Tyr Thr Pro Leu His Ile 
        595                 600                 605             


Ala Ala Lys Gln Asn Gln Val Glu Val Ala Arg Ser Leu Leu Gln Tyr 
    610                 615                 620                 


Gly Gly Ser Ala Asn Ala Glu Ser Val Gln Gly Val Thr Pro Leu His 
625                 630                 635                 640 


Leu Ala Ala Gln Glu Gly His Ala Glu Met Val Ala Leu Leu Leu Ser 
                645                 650                 655     


Lys Gln Ala Asn Gly Asn Leu Gly Asn Lys Ser Gly Leu Thr Pro Leu 
            660                 665                 670         


His Leu Val Ala Gln Glu Gly His Val Pro Val Ala Asp Val Leu Ile 
        675                 680                 685             


Lys His Gly Val Met Val Asp Ala Thr Thr Arg Met Gly Tyr Thr Pro 
    690                 695                 700                 


Leu His Val Ala Ser His Tyr Gly Asn Ile Lys Leu Val Lys Phe Leu 
705                 710                 715                 720 


Leu Gln His Gln Ala Asp Val Asn Ala Lys Thr Lys Leu Gly Tyr Ser 
                725                 730                 735     


Pro Leu His Gln Ala Ala Gln Gln Gly His Thr Asp Ile Val Thr Leu 
            740                 745                 750         


Leu Leu Lys Asn Gly Ala Ser Pro Asn Glu Val Ser Ser Asp Gly Thr 
        755                 760                 765             


Thr Pro Leu Ala Ile Ala Lys Arg Leu Gly Tyr Ile Ser Val Thr Asp 
    770                 775                 780                 


Val Leu Lys Val Val Thr Asp Glu Thr Ser Phe Val Leu Val Ser Asp 
785                 790                 795                 800 


Lys His Arg Met Ser Phe Pro Glu Thr Val Asp Glu Ile Leu Asp Val 
                805                 810                 815     


Ser Glu Asp Glu Gly Glu Glu Leu Ile Ser Phe Lys Ala Glu Arg Arg 
            820                 825                 830         


Asp Ser Arg Asp Val Asp Glu Glu Lys Glu Leu Leu Asp Phe Val Pro 
        835                 840                 845             


Lys Leu Asp Gln Val Val Glu Ser Pro Ala Ile Pro Arg Ile Pro Cys 
    850                 855                 860                 


Ala Met Pro Glu Thr Val Val Ile Arg Ser Glu Glu Gln Glu Gln Ala 
865                 870                 875                 880 


Ser Lys Glu Tyr Asp Glu Asp Ser Leu Ile Pro Ser Ser Pro Ala Thr 
                885                 890                 895     


Glu Thr Ser Asp Asn Ile Ser Pro Val Ala Ser Pro Val His Thr Gly 
            900                 905                 910         


Phe Leu Val Ser Phe Met Val Asp Ala Arg Gly Gly Ser Met Arg Gly 
        915                 920                 925             


Ser Arg His Asn Gly Leu Arg Val Val Ile Pro Pro Arg Thr Cys Ala 
    930                 935                 940                 


Ala Pro Thr Arg Ile Thr Cys Arg Leu Val Lys Pro Gln Lys Leu Ser 
945                 950                 955                 960 


Thr Pro Pro Pro Leu Ala Glu Glu Glu Gly Leu Ala Ser Arg Ile Ile 
                965                 970                 975     


Ala Leu Gly Pro Thr Gly Ala Gln Phe Leu Ser Pro Val Ile Val Glu 
            980                 985                 990         


Ile Pro His Phe Ala Ser His Gly  Arg Gly Asp Arg Glu  Leu Val Val 
        995                 1000                 1005             


Leu Arg  Ser Glu Asn Gly Ser  Val Trp Lys Glu His  Arg Ser Arg 
    1010                 1015                 1020             


Tyr Gly  Glu Ser Tyr Leu Asp  Gln Ile Leu Asn Gly  Met Asp Glu 
    1025                 1030                 1035             


Glu Leu  Gly Ser Leu Glu Glu  Leu Glu Lys Lys Arg  Val Cys Arg 
    1040                 1045                 1050             


Ile Ile  Thr Thr Asp Phe Pro  Leu Tyr Phe Val Ile  Met Ser Arg 
    1055                 1060                 1065             


Leu Cys  Gln Asp Tyr Asp Thr  Ile Gly Pro Glu Gly  Gly Ser Leu 
    1070                 1075                 1080             


Lys Ser  Lys Leu Val Pro Leu  Val Gln Ala Thr Phe  Pro Glu Asn 
    1085                 1090                 1095             


Ala Val  Thr Lys Arg Val Lys  Leu Ala Leu Gln Ala  Gln Pro Val 
    1100                 1105                 1110             


Pro Asp  Glu Leu Val Thr Lys  Leu Leu Gly Asn Gln  Ala Thr Phe 
    1115                 1120                 1125             


Ser Pro  Ile Val Thr Val Glu  Pro Arg Arg Arg Lys  Phe His Arg 
    1130                 1135                 1140             


Pro Ile  Gly Leu Arg Ile Pro  Leu Pro Pro Ser Trp  Thr Asp Asn 
    1145                 1150                 1155             


Pro Arg  Asp Ser Gly Glu Gly  Asp Thr Thr Ser Leu  Arg Leu Leu 
    1160                 1165                 1170             


Cys Ser  Val Ile Gly Gly Thr  Asp Gln Ala Gln Trp  Glu Asp Ile 
    1175                 1180                 1185             


Thr Gly  Thr Thr Lys Leu Val  Tyr Ala Asn Glu Cys  Ala Asn Phe 
    1190                 1195                 1200             


Thr Thr  Asn Val Ser Ala Arg  Phe Trp Leu Ser Asp  Cys Pro Arg 
    1205                 1210                 1215             


Thr Ala  Glu Ala Val Asn Phe  Ala Thr Leu Leu Tyr  Lys Glu Leu 
    1220                 1225                 1230             


Thr Ala  Val Pro Tyr Met Ala  Lys Phe Val Ile Phe  Ala Lys Met 
    1235                 1240                 1245             


Asn Asp  Pro Arg Glu Gly Arg  Leu Arg Cys Tyr Cys  Met Thr Asp 
    1250                 1255                 1260             


Asp Lys  Val Asp Lys Thr Leu  Glu Gln His Glu Asn  Phe Val Glu 
    1265                 1270                 1275             


Val Ala  Arg Ser Arg Asp Ile  Glu Val Leu Glu Gly  Met Ser Leu 
    1280                 1285                 1290             


Phe Ala  Glu Leu Ser Gly Asn  Leu Val Pro Val Lys  Lys Ala Ala 
    1295                 1300                 1305             


Gln Gln  Arg Ser Phe His Phe  Gln Ser Phe Arg Glu  Asn Arg Leu 
    1310                 1315                 1320             


Ala Met  Pro Val Lys Val Arg  Asp Ser Ser Arg Glu  Pro Gly Gly 
    1325                 1330                 1335             


Ser Leu  Ser Phe Leu Arg Lys  Ala Met Lys Tyr Glu  Asp Thr Gln 
    1340                 1345                 1350             


His Ile  Leu Cys His Leu Asn  Ile Thr Met Pro Pro  Cys Ala Lys 
    1355                 1360                 1365             


Gly Ser  Gly Ala Glu Asp Arg  Arg Arg Thr Pro Thr  Pro Leu Ala 
    1370                 1375                 1380             


Leu Arg  Tyr Ser Ile Leu Ser  Glu Ser Thr Pro Gly  Ser Leu Ser 
    1385                 1390                 1395             


Gly Thr  Glu Gln Ala Glu Met  Lys Met Ala Val Ile  Ser Glu His 
    1400                 1405                 1410             


Leu Gly  Leu Ser Trp Ala Glu  Leu Ala Arg Glu Leu  Gln Phe Ser 
    1415                 1420                 1425             


Val Glu  Asp Ile Asn Arg Ile  Arg Val Glu Asn Pro  Asn Ser Leu 
    1430                 1435                 1440             


Leu Glu  Gln Ser Val Ala Leu  Leu Asn Leu Trp Val  Ile Arg Glu 
    1445                 1450                 1455             


Gly Gln  Asn Ala Asn Met Glu  Asn Leu Tyr Thr Ala  Leu Gln Ser 
    1460                 1465                 1470             


Ile Asp  Arg Gly Glu Ile Val  Asn Met Leu Glu Gly  Ser Gly Arg 
    1475                 1480                 1485             


Gln Ser  Arg Asn Leu Lys Pro  Asp Arg Arg His Thr  Asp Arg Asp 
    1490                 1495                 1500             


Tyr Ser  Leu Ser Pro Ser Gln  Met Asn Gly Tyr Ser  Ser Leu Gln 
    1505                 1510                 1515             


Asp Glu  Leu Leu Ser Pro Ala  Ser Leu Gly Cys Ala  Leu Ser Ser 
    1520                 1525                 1530             


Pro Leu  Arg Ala Asp Gln Tyr  Trp Asn Glu Val Ala  Val Leu Asp 
    1535                 1540                 1545             


Ala Ile  Pro Leu Ala Ala Thr  Glu His Asp Thr Met  Leu Glu Met 
    1550                 1555                 1560             


Ser Asp  Met Gln Val Trp Ser  Ala Gly Leu Thr Pro  Ser Leu Val 
    1565                 1570                 1575             


Thr Ala  Glu Asp Ser Ser Leu  Glu Cys Ser Lys Ala  Glu Asp Ser 
    1580                 1585                 1590             


Asp Ala  Thr Gly His Glu Trp  Lys Leu Glu Gly Ala  Leu Ser Glu 
    1595                 1600                 1605             


Glu Pro  Arg Gly Pro Glu Leu  Gly Ser Leu Glu Leu  Val Glu Asp 
    1610                 1615                 1620             


Asp Thr  Val Asp Ser Asp Ala  Thr Asn Gly Leu Ile  Asp Leu Leu 
    1625                 1630                 1635             


Glu Gln  Glu Glu Gly Gln Arg  Ser Glu Glu Lys Leu  Pro Gly Ser 
    1640                 1645                 1650             


Lys Arg  Gln Asp Asp Ala Thr  Gly Ala Gly Gln Asp  Ser Glu Asn 
    1655                 1660                 1665             


Glu Val  Ser Leu Val Ser Gly  His Gln Arg Gly Gln  Ala Arg Ile 
    1670                 1675                 1680             


Thr His  Ser Pro Thr Val Ser  Gln Val Thr Glu Arg  Ser Gln Asp 
    1685                 1690                 1695             


Arg Leu  Gln Asp Trp Asp Ala  Asp Gly Ser Ile Val  Ser Tyr Leu 
    1700                 1705                 1710             


Gln Asp  Ala Ala Gln Gly Ser  Trp Gln Glu Glu Val  Thr Gln Gly 
    1715                 1720                 1725             


Pro His  Ser Phe Gln Gly Thr  Ser Thr Met Thr Glu  Gly Leu Glu 
    1730                 1735                 1740             


Pro Gly  Gly Ser Gln Glu Tyr  Glu Lys Val Leu Val  Ser Val Ser 
    1745                 1750                 1755             


Glu His  Thr Trp Thr Glu Gln  Pro Glu Ala Glu Ser  Ser Gln Ala 
    1760                 1765                 1770             


Asp Arg  Asp Arg Arg Gln Gln  Gly Gln Glu Glu Gln  Val Gln Glu 
    1775                 1780                 1785             


Ala Lys  Asn Thr Phe Thr Gln  Val Val Gln Gly Asn  Glu Phe Gln 
    1790                 1795                 1800             


Asn Ile  Pro Gly Glu Gln Val  Thr Glu Glu Gln Phe  Thr Asp Glu 
    1805                 1810                 1815             


Gln Gly  Asn Ile Val Thr Lys  Lys Ile Ile Arg Lys  Val Val Arg 
    1820                 1825                 1830             


Gln Ile  Asp Leu Ser Ser Ala  Asp Ala Ala Gln Glu  His Glu Glu 
    1835                 1840                 1845             


Val Thr  Val Glu Gly Pro Leu  Glu Asp Pro Ser Glu  Leu Glu Val 
    1850                 1855                 1860             


Asp Ile  Asp Tyr Phe Met Lys  His Ser Lys Asp His  Thr Ser Thr 
    1865                 1870                 1875             


Pro Asn  Pro 
    1880     


<210>  4
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Trp Thr Phe Val Thr Gln Leu Leu Val Thr Leu Val Leu Leu Ser 
1               5                   10                  15      


Phe Phe Leu Val Ser Cys Gln Asn Val Met His Ile Val Arg Gly Ser 
            20                  25                  30          


Leu Cys Phe Val Leu Lys His Ile His Gln Glu Leu Asp Lys Glu Leu 
        35                  40                  45              


Gly Glu Ser Glu Gly Leu Ser Asp Asp Glu Glu Thr Ile Ser Thr Arg 
    50                  55                  60                  


Val Val Arg Arg Arg Val Phe Leu Lys Gly Asn Glu Phe Gln Asn Ile 
65                  70                  75                  80  


Pro Gly Glu Gln Val Thr Glu Glu Gln Phe Thr Asp Glu Gln Gly Asn 
                85                  90                  95      


Ile Val Thr Lys Lys Ile Ile Arg Lys Val Val Arg Gln Ile Asp Leu 
            100                 105                 110         


Ser Ser Ala Asp Ala Ala Gln Glu His Glu Glu Asp His Thr Ser Thr 
        115                 120                 125             


Pro Asn Pro 
    130     


<210>  5
<211>  864
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Thr Thr Glu Lys Ser Leu Val Thr Glu Ala Glu Asn Ser Gln His 
1               5                   10                  15      


Gln Gln Lys Glu Glu Gly Glu Glu Ala Ile Asn Ser Gly Gln Gln Glu 
            20                  25                  30          


Pro Gln Gln Glu Glu Ser Cys Gln Thr Ala Ala Glu Gly Asp Asn Trp 
        35                  40                  45              


Cys Glu Gln Lys Leu Lys Ala Ser Asn Gly Asp Thr Pro Thr His Glu 
    50                  55                  60                  


Asp Leu Thr Lys Asn Lys Glu Arg Thr Ser Glu Ser Arg Gly Leu Ser 
65                  70                  75                  80  


Arg Leu Phe Ser Ser Phe Leu Lys Arg Pro Lys Ser Gln Val Ser Glu 
                85                  90                  95      


Glu Glu Gly Lys Glu Val Glu Ser Asp Lys Glu Lys Gly Glu Gly Gly 
            100                 105                 110         


Gln Lys Glu Ile Glu Phe Gly Thr Ser Leu Asp Glu Glu Ile Ile Leu 
        115                 120                 125             


Lys Ala Pro Ile Ala Ala Pro Glu Pro Glu Leu Lys Thr Asp Pro Ser 
    130                 135                 140                 


Leu Asp Leu His Ser Leu Ser Ser Ala Glu Thr Gln Pro Ala Gln Glu 
145                 150                 155                 160 


Glu Leu Arg Glu Asp Pro Asp Phe Glu Ile Lys Glu Gly Glu Gly Leu 
                165                 170                 175     


Glu Glu Cys Ser Lys Ile Glu Val Lys Glu Glu Ser Pro Gln Ser Lys 
            180                 185                 190         


Ala Glu Thr Glu Leu Lys Ala Ser Gln Lys Pro Ile Arg Lys His Arg 
        195                 200                 205             


Asn Met His Cys Lys Val Ser Leu Leu Asp Asp Thr Val Tyr Glu Cys 
    210                 215                 220                 


Val Val Glu Lys His Ala Lys Gly Gln Asp Leu Leu Lys Arg Val Cys 
225                 230                 235                 240 


Glu His Leu Asn Leu Leu Glu Glu Asp Tyr Phe Gly Leu Ala Ile Trp 
                245                 250                 255     


Asp Asn Ala Thr Ser Lys Thr Trp Leu Asp Ser Ala Lys Glu Ile Lys 
            260                 265                 270         


Lys Gln Val Arg Gly Val Pro Trp Asn Phe Thr Phe Asn Val Lys Phe 
        275                 280                 285             


Tyr Pro Pro Asp Pro Ala Gln Leu Thr Glu Asp Ile Thr Arg Tyr Tyr 
    290                 295                 300                 


Leu Cys Leu Gln Leu Arg Gln Asp Ile Val Ala Gly Arg Leu Pro Cys 
305                 310                 315                 320 


Ser Phe Ala Thr Leu Ala Leu Leu Gly Ser Tyr Thr Ile Gln Ser Glu 
                325                 330                 335     


Leu Gly Asp Tyr Asp Pro Glu Leu His Gly Val Asp Tyr Val Ser Asp 
            340                 345                 350         


Phe Lys Leu Ala Pro Asn Gln Thr Lys Glu Leu Glu Glu Lys Val Met 
        355                 360                 365             


Glu Leu His Lys Ser Tyr Arg Ser Met Thr Pro Ala Gln Ala Asp Leu 
    370                 375                 380                 


Glu Phe Leu Glu Asn Ala Lys Lys Leu Ser Met Tyr Gly Val Asp Leu 
385                 390                 395                 400 


His Lys Ala Lys Asp Leu Glu Gly Val Asp Ile Ile Leu Gly Val Cys 
                405                 410                 415     


Ser Ser Gly Leu Leu Val Tyr Lys Asp Lys Leu Arg Ile Asn Arg Phe 
            420                 425                 430         


Pro Trp Pro Lys Val Leu Lys Ile Ser Tyr Lys Arg Ser Ser Phe Phe 
        435                 440                 445             


Ile Lys Ile Arg Pro Gly Glu Gln Glu Gln Tyr Glu Ser Thr Ile Gly 
    450                 455                 460                 


Phe Lys Leu Pro Ser Tyr Arg Ala Ala Lys Lys Leu Trp Lys Val Cys 
465                 470                 475                 480 


Val Glu His His Thr Phe Phe Arg Leu Thr Ser Thr Asp Thr Ile Pro 
                485                 490                 495     


Lys Ser Lys Phe Leu Ala Leu Gly Ser Lys Phe Arg Tyr Ser Gly Arg 
            500                 505                 510         


Thr Gln Ala Gln Thr Arg Gln Ala Ser Ala Leu Ile Asp Arg Pro Ala 
        515                 520                 525             


Pro His Phe Glu Arg Thr Ala Ser Lys Arg Ala Ser Arg Ser Leu Asp 
    530                 535                 540                 


Gly Ala Ala Ala Val Asp Ser Ala Asp Arg Ser Pro Arg Pro Thr Ser 
545                 550                 555                 560 


Ala Pro Ala Ile Thr Gln Gly Gln Val Ala Glu Gly Gly Val Leu Asp 
                565                 570                 575     


Ala Ser Ala Lys Lys Thr Val Val Pro Lys Ala Gln Lys Glu Thr Val 
            580                 585                 590         


Lys Ala Glu Val Lys Lys Glu Asp Glu Pro Pro Glu Gln Ala Glu Pro 
        595                 600                 605             


Glu Pro Thr Glu Ala Trp Lys Val Glu Lys Thr His Ile Glu Val Thr 
    610                 615                 620                 


Val Pro Thr Ser Asn Gly Asp Gln Thr Gln Lys Leu Ala Glu Lys Thr 
625                 630                 635                 640 


Glu Asp Leu Ile Arg Met Arg Lys Lys Lys Arg Glu Arg Leu Asp Gly 
                645                 650                 655     


Glu Asn Ile Tyr Ile Arg His Ser Asn Leu Met Leu Glu Asp Leu Asp 
            660                 665                 670         


Lys Ser Gln Glu Glu Ile Lys Lys His His Ala Ser Ile Ser Glu Leu 
        675                 680                 685             


Lys Lys Asn Phe Met Glu Ser Val Pro Glu Pro Arg Pro Ser Glu Trp 
    690                 695                 700                 


Asp Lys Arg Leu Ser Thr His Ser Pro Phe Arg Thr Leu Asn Ile Asn 
705                 710                 715                 720 


Gly Gln Ile Pro Thr Gly Glu Gly Pro Pro Leu Val Lys Thr Gln Thr 
                725                 730                 735     


Val Thr Ile Ser Asp Asn Ala Asn Ala Val Lys Ser Glu Ile Pro Thr 
            740                 745                 750         


Lys Asp Val Pro Ile Val His Thr Glu Thr Lys Thr Ile Thr Tyr Glu 
        755                 760                 765             


Ala Ala Gln Thr Asp Asp Asn Ser Gly Asp Leu Asp Pro Gly Val Leu 
    770                 775                 780                 


Leu Thr Ala Gln Thr Ile Thr Ser Glu Thr Pro Ser Ser Thr Thr Thr 
785                 790                 795                 800 


Thr Gln Ile Thr Lys Thr Val Lys Gly Gly Ile Ser Glu Thr Arg Ile 
                805                 810                 815     


Glu Lys Arg Ile Val Ile Thr Gly Asp Ala Asp Ile Asp His Asp Gln 
            820                 825                 830         


Val Leu Val Gln Ala Ile Lys Glu Ala Lys Glu Gln His Pro Asp Met 
        835                 840                 845             


Ser Val Thr Lys Val Val Val His Gln Glu Thr Glu Ile Ala Asp Glu 
    850                 855                 860                 


<210>  6
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Val Leu Ser Pro Ala Asp Lys Thr Asn Val Lys Ala Ala Trp Gly 
1               5                   10                  15      


Lys Val Gly Ala His Ala Gly Glu Tyr Gly Ala Glu Ala Leu Glu Arg 
            20                  25                  30          


Met Phe Leu Ser Phe Pro Thr Thr Lys Thr Tyr Phe Pro His Phe Asp 
        35                  40                  45              


Leu Ser His Gly Ser Ala Gln Val Lys Gly His Gly Lys Lys Val Ala 
    50                  55                  60                  


Asp Ala Leu Thr Asn Ala Val Ala His Val Asp Asp Met Pro Asn Ala 
65                  70                  75                  80  


Leu Ser Ala Leu Ser Asp Leu His Ala His Lys Leu Arg Val Asp Pro 
                85                  90                  95      


Val Asn Phe Lys Leu Leu Ser His Cys Leu Leu Val Thr Leu Ala Ala 
            100                 105                 110         


His Leu Pro Ala Glu Phe Thr Pro Ala Val His Ala Ser Leu Asp Lys 
        115                 120                 125             


Phe Leu Ala Ser Val Ser Thr Val Leu Thr Ser Lys Tyr Arg 
    130                 135                 140         


<210>  7
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Phe Leu Ser Phe Pro Thr Thr Lys Thr Tyr Phe Pro His Phe Asp 
1               5                   10                  15      


Leu Ser His Gly Ser Ala Gln Val Lys Gly His Gly Lys Lys Val Ala 
            20                  25                  30          


Asp Ala Leu Thr Asn Ala Val Ala His Val Asp Asp Met Pro Asn Ala 
        35                  40                  45              


Leu Ser Ala Leu Ser Asp Leu His Ala His Lys Leu Arg Val Asp Pro 
    50                  55                  60                  


Val Asn Phe Lys Leu Leu Ser His Cys Leu Leu Val Thr Leu Ala Ala 
65                  70                  75                  80  


His Leu Pro Ala Glu Phe Thr Pro Ala Val His Ala Ser Leu Asp Lys 
                85                  90                  95      


Phe Leu Ala Ser Val Ser Thr Val Leu Thr Ser Lys Tyr Arg 
            100                 105                 110 


<210>  8
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Val His Leu Thr Pro Glu Glu Lys Ser Ala Val Thr Ala Leu Trp 
1               5                   10                  15      


Gly Lys Val Asn Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu 
            20                  25                  30          


Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp 
        35                  40                  45              


Leu Ser Thr Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His 
    50                  55                  60                  


Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp 
65                  70                  75                  80  


Asn Leu Lys Gly Thr Phe Ala Thr Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val 
            100                 105                 110         


Cys Val Leu Ala His His Phe Gly Lys Glu Phe Thr Pro Pro Val Gln 
        115                 120                 125             


Ala Ala Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His 
    130                 135                 140                 


Lys Tyr His 
145         


<210>  9
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Val His Leu Thr Pro Glu Glu Lys Thr Ala Val Asn Ala Leu Trp 
1               5                   10                  15      


Gly Lys Val Asn Val Asp Ala Val Gly Gly Glu Ala Leu Gly Arg Leu 
            20                  25                  30          


Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp 
        35                  40                  45              


Leu Ser Ser Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His 
    50                  55                  60                  


Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp 
65                  70                  75                  80  


Asn Leu Lys Gly Thr Phe Ser Gln Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Glu Asn Phe 
            100                 


<210>  10
<211>  1663
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gly Pro Thr Ser Gly Pro Ser Leu Leu Leu Leu Leu Leu Thr His 
1               5                   10                  15      


Leu Pro Leu Ala Leu Gly Ser Pro Met Tyr Ser Ile Ile Thr Pro Asn 
            20                  25                  30          


Ile Leu Arg Leu Glu Ser Glu Glu Thr Met Val Leu Glu Ala His Asp 
        35                  40                  45              


Ala Gln Gly Asp Val Pro Val Thr Val Thr Val His Asp Phe Pro Gly 
    50                  55                  60                  


Lys Lys Leu Val Leu Ser Ser Glu Lys Thr Val Leu Thr Pro Ala Thr 
65                  70                  75                  80  


Asn His Met Gly Asn Val Thr Phe Thr Ile Pro Ala Asn Arg Glu Phe 
                85                  90                  95      


Lys Ser Glu Lys Gly Arg Asn Lys Phe Val Thr Val Gln Ala Thr Phe 
            100                 105                 110         


Gly Thr Gln Val Val Glu Lys Val Val Leu Val Ser Leu Gln Ser Gly 
        115                 120                 125             


Tyr Leu Phe Ile Gln Thr Asp Lys Thr Ile Tyr Thr Pro Gly Ser Thr 
    130                 135                 140                 


Val Leu Tyr Arg Ile Phe Thr Val Asn His Lys Leu Leu Pro Val Gly 
145                 150                 155                 160 


Arg Thr Val Met Val Asn Ile Glu Asn Pro Glu Gly Ile Pro Val Lys 
                165                 170                 175     


Gln Asp Ser Leu Ser Ser Gln Asn Gln Leu Gly Val Leu Pro Leu Ser 
            180                 185                 190         


Trp Asp Ile Pro Glu Leu Val Asn Met Gly Gln Trp Lys Ile Arg Ala 
        195                 200                 205             


Tyr Tyr Glu Asn Ser Pro Gln Gln Val Phe Ser Thr Glu Phe Glu Val 
    210                 215                 220                 


Lys Glu Tyr Val Leu Pro Ser Phe Glu Val Ile Val Glu Pro Thr Glu 
225                 230                 235                 240 


Lys Phe Tyr Tyr Ile Tyr Asn Glu Lys Gly Leu Glu Val Thr Ile Thr 
                245                 250                 255     


Ala Arg Phe Leu Tyr Gly Lys Lys Val Glu Gly Thr Ala Phe Val Ile 
            260                 265                 270         


Phe Gly Ile Gln Asp Gly Glu Gln Arg Ile Ser Leu Pro Glu Ser Leu 
        275                 280                 285             


Lys Arg Ile Pro Ile Glu Asp Gly Ser Gly Glu Val Val Leu Ser Arg 
    290                 295                 300                 


Lys Val Leu Leu Asp Gly Val Gln Asn Pro Arg Ala Glu Asp Leu Val 
305                 310                 315                 320 


Gly Lys Ser Leu Tyr Val Ser Ala Thr Val Ile Leu His Ser Gly Ser 
                325                 330                 335     


Asp Met Val Gln Ala Glu Arg Ser Gly Ile Pro Ile Val Thr Ser Pro 
            340                 345                 350         


Tyr Gln Ile His Phe Thr Lys Thr Pro Lys Tyr Phe Lys Pro Gly Met 
        355                 360                 365             


Pro Phe Asp Leu Met Val Phe Val Thr Asn Pro Asp Gly Ser Pro Ala 
    370                 375                 380                 


Tyr Arg Val Pro Val Ala Val Gln Gly Glu Asp Thr Val Gln Ser Leu 
385                 390                 395                 400 


Thr Gln Gly Asp Gly Val Ala Lys Leu Ser Ile Asn Thr His Pro Ser 
                405                 410                 415     


Gln Lys Pro Leu Ser Ile Thr Val Arg Thr Lys Lys Gln Glu Leu Ser 
            420                 425                 430         


Glu Ala Glu Gln Ala Thr Arg Thr Met Gln Ala Leu Pro Tyr Ser Thr 
        435                 440                 445             


Val Gly Asn Ser Asn Asn Tyr Leu His Leu Ser Val Leu Arg Thr Glu 
    450                 455                 460                 


Leu Arg Pro Gly Glu Thr Leu Asn Val Asn Phe Leu Leu Arg Met Asp 
465                 470                 475                 480 


Arg Ala His Glu Ala Lys Ile Arg Tyr Tyr Thr Tyr Leu Ile Met Asn 
                485                 490                 495     


Lys Gly Arg Leu Leu Lys Ala Gly Arg Gln Val Arg Glu Pro Gly Gln 
            500                 505                 510         


Asp Leu Val Val Leu Pro Leu Ser Ile Thr Thr Asp Phe Ile Pro Ser 
        515                 520                 525             


Phe Arg Leu Val Ala Tyr Tyr Thr Leu Ile Gly Ala Ser Gly Gln Arg 
    530                 535                 540                 


Glu Val Val Ala Asp Ser Val Trp Val Asp Val Lys Asp Ser Cys Val 
545                 550                 555                 560 


Gly Ser Leu Val Val Lys Ser Gly Gln Ser Glu Asp Arg Gln Pro Val 
                565                 570                 575     


Pro Gly Gln Gln Met Thr Leu Lys Ile Glu Gly Asp His Gly Ala Arg 
            580                 585                 590         


Val Val Leu Val Ala Val Asp Lys Gly Val Phe Val Leu Asn Lys Lys 
        595                 600                 605             


Asn Lys Leu Thr Gln Ser Lys Ile Trp Asp Val Val Glu Lys Ala Asp 
    610                 615                 620                 


Ile Gly Cys Thr Pro Gly Ser Gly Lys Asp Tyr Ala Gly Val Phe Ser 
625                 630                 635                 640 


Asp Ala Gly Leu Thr Phe Thr Ser Ser Ser Gly Gln Gln Thr Ala Gln 
                645                 650                 655     


Arg Ala Glu Leu Gln Cys Pro Gln Pro Ala Ala Arg Arg Arg Arg Ser 
            660                 665                 670         


Val Gln Leu Thr Glu Lys Arg Met Asp Lys Val Gly Lys Tyr Pro Lys 
        675                 680                 685             


Glu Leu Arg Lys Cys Cys Glu Asp Gly Met Arg Glu Asn Pro Met Arg 
    690                 695                 700                 


Phe Ser Cys Gln Arg Arg Thr Arg Phe Ile Ser Leu Gly Glu Ala Cys 
705                 710                 715                 720 


Lys Lys Val Phe Leu Asp Cys Cys Asn Tyr Ile Thr Glu Leu Arg Arg 
                725                 730                 735     


Gln His Ala Arg Ala Ser His Leu Gly Leu Ala Arg Ser Asn Leu Asp 
            740                 745                 750         


Glu Asp Ile Ile Ala Glu Glu Asn Ile Val Ser Arg Ser Glu Phe Pro 
        755                 760                 765             


Glu Ser Trp Leu Trp Asn Val Glu Asp Leu Lys Glu Pro Pro Lys Asn 
    770                 775                 780                 


Gly Ile Ser Thr Lys Leu Met Asn Ile Phe Leu Lys Asp Ser Ile Thr 
785                 790                 795                 800 


Thr Trp Glu Ile Leu Ala Val Ser Met Ser Asp Lys Lys Gly Ile Cys 
                805                 810                 815     


Val Ala Asp Pro Phe Glu Val Thr Val Met Gln Asp Phe Phe Ile Asp 
            820                 825                 830         


Leu Arg Leu Pro Tyr Ser Val Val Arg Asn Glu Gln Val Glu Ile Arg 
        835                 840                 845             


Ala Val Leu Tyr Asn Tyr Arg Gln Asn Gln Glu Leu Lys Val Arg Val 
    850                 855                 860                 


Glu Leu Leu His Asn Pro Ala Phe Cys Ser Leu Ala Thr Thr Lys Arg 
865                 870                 875                 880 


Arg His Gln Gln Thr Val Thr Ile Pro Pro Lys Ser Ser Leu Ser Val 
                885                 890                 895     


Pro Tyr Val Ile Val Pro Leu Lys Thr Gly Leu Gln Glu Val Glu Val 
            900                 905                 910         


Lys Ala Ala Val Tyr His His Phe Ile Ser Asp Gly Val Arg Lys Ser 
        915                 920                 925             


Leu Lys Val Val Pro Glu Gly Ile Arg Met Asn Lys Thr Val Ala Val 
    930                 935                 940                 


Arg Thr Leu Asp Pro Glu Arg Leu Gly Arg Glu Gly Val Gln Lys Glu 
945                 950                 955                 960 


Asp Ile Pro Pro Ala Asp Leu Ser Asp Gln Val Pro Asp Thr Glu Ser 
                965                 970                 975     


Glu Thr Arg Ile Leu Leu Gln Gly Thr Pro Val Ala Gln Met Thr Glu 
            980                 985                 990         


Asp Ala Val Asp Ala Glu Arg Leu  Lys His Leu Ile Val  Thr Pro Ser 
        995                 1000                 1005             


Gly Cys  Gly Glu Gln Asn Met  Ile Gly Met Thr Pro  Thr Val Ile 
    1010                 1015                 1020             


Ala Val  His Tyr Leu Asp Glu  Thr Glu Gln Trp Glu  Lys Phe Gly 
    1025                 1030                 1035             


Leu Glu  Lys Arg Gln Gly Ala  Leu Glu Leu Ile Lys  Lys Gly Tyr 
    1040                 1045                 1050             


Thr Gln  Gln Leu Ala Phe Arg  Gln Pro Ser Ser Ala  Phe Ala Ala 
    1055                 1060                 1065             


Phe Val  Lys Arg Ala Pro Ser  Thr Trp Leu Thr Ala  Tyr Val Val 
    1070                 1075                 1080             


Lys Val  Phe Ser Leu Ala Val  Asn Leu Ile Ala Ile  Asp Ser Gln 
    1085                 1090                 1095             


Val Leu  Cys Gly Ala Val Lys  Trp Leu Ile Leu Glu  Lys Gln Lys 
    1100                 1105                 1110             


Pro Asp  Gly Val Phe Gln Glu  Asp Ala Pro Val Ile  His Gln Glu 
    1115                 1120                 1125             


Met Ile  Gly Gly Leu Arg Asn  Asn Asn Glu Lys Asp  Met Ala Leu 
    1130                 1135                 1140             


Thr Ala  Phe Val Leu Ile Ser  Leu Gln Glu Ala Lys  Asp Ile Cys 
    1145                 1150                 1155             


Glu Glu  Gln Val Asn Ser Leu  Pro Gly Ser Ile Thr  Lys Ala Gly 
    1160                 1165                 1170             


Asp Phe  Leu Glu Ala Asn Tyr  Met Asn Leu Gln Arg  Ser Tyr Thr 
    1175                 1180                 1185             


Val Ala  Ile Ala Gly Tyr Ala  Leu Ala Gln Met Gly  Arg Leu Lys 
    1190                 1195                 1200             


Gly Pro  Leu Leu Asn Lys Phe  Leu Thr Thr Ala Lys  Asp Lys Asn 
    1205                 1210                 1215             


Arg Trp  Glu Asp Pro Gly Lys  Gln Leu Tyr Asn Val  Glu Ala Thr 
    1220                 1225                 1230             


Ser Tyr  Ala Leu Leu Ala Leu  Leu Gln Leu Lys Asp  Phe Asp Phe 
    1235                 1240                 1245             


Val Pro  Pro Val Val Arg Trp  Leu Asn Glu Gln Arg  Tyr Tyr Gly 
    1250                 1255                 1260             


Gly Gly  Tyr Gly Ser Thr Gln  Ala Thr Phe Met Val  Phe Gln Ala 
    1265                 1270                 1275             


Leu Ala  Gln Tyr Gln Lys Asp  Ala Pro Asp His Gln  Glu Leu Asn 
    1280                 1285                 1290             


Leu Asp  Val Ser Leu Gln Leu  Pro Ser Arg Ser Ser  Lys Ile Thr 
    1295                 1300                 1305             


His Arg  Ile His Trp Glu Ser  Ala Ser Leu Leu Arg  Ser Glu Glu 
    1310                 1315                 1320             


Thr Lys  Glu Asn Glu Gly Phe  Thr Val Thr Ala Glu  Gly Lys Gly 
    1325                 1330                 1335             


Gln Gly  Thr Leu Ser Val Val  Thr Met Tyr His Ala  Lys Ala Lys 
    1340                 1345                 1350             


Asp Gln  Leu Thr Cys Asn Lys  Phe Asp Leu Lys Val  Thr Ile Lys 
    1355                 1360                 1365             


Pro Ala  Pro Glu Thr Glu Lys  Arg Pro Gln Asp Ala  Lys Asn Thr 
    1370                 1375                 1380             


Met Ile  Leu Glu Ile Cys Thr  Arg Tyr Arg Gly Asp  Gln Asp Ala 
    1385                 1390                 1395             


Thr Met  Ser Ile Leu Asp Ile  Ser Met Met Thr Gly  Phe Ala Pro 
    1400                 1405                 1410             


Asp Thr  Asp Asp Leu Lys Gln  Leu Ala Asn Gly Val  Asp Arg Tyr 
    1415                 1420                 1425             


Ile Ser  Lys Tyr Glu Leu Asp  Lys Ala Phe Ser Asp  Arg Asn Thr 
    1430                 1435                 1440             


Leu Ile  Ile Tyr Leu Asp Lys  Val Ser His Ser Glu  Asp Asp Cys 
    1445                 1450                 1455             


Leu Ala  Phe Lys Val His Gln  Tyr Phe Asn Val Glu  Leu Ile Gln 
    1460                 1465                 1470             


Pro Gly  Ala Val Lys Val Tyr  Ala Tyr Tyr Asn Leu  Glu Glu Ser 
    1475                 1480                 1485             


Cys Thr  Arg Phe Tyr His Pro  Glu Lys Glu Asp Gly  Lys Leu Asn 
    1490                 1495                 1500             


Lys Leu  Cys Arg Asp Glu Leu  Cys Arg Cys Ala Glu  Glu Asn Cys 
    1505                 1510                 1515             


Phe Ile  Gln Lys Ser Asp Asp  Lys Val Thr Leu Glu  Glu Arg Leu 
    1520                 1525                 1530             


Asp Lys  Ala Cys Glu Pro Gly  Val Asp Tyr Val Tyr  Lys Thr Arg 
    1535                 1540                 1545             


Leu Val  Lys Val Gln Leu Ser  Asn Asp Phe Asp Glu  Tyr Ile Met 
    1550                 1555                 1560             


Ala Ile  Glu Gln Thr Ile Lys  Ser Gly Ser Asp Glu  Val Gln Val 
    1565                 1570                 1575             


Gly Gln  Gln Arg Thr Phe Ile  Ser Pro Ile Lys Cys  Arg Glu Ala 
    1580                 1585                 1590             


Leu Lys  Leu Glu Glu Lys Lys  His Tyr Leu Met Trp  Gly Leu Ser 
    1595                 1600                 1605             


Ser Asp  Phe Trp Gly Glu Lys  Pro Asn Leu Ser Tyr  Ile Ile Gly 
    1610                 1615                 1620             


Lys Asp  Thr Trp Val Glu His  Trp Pro Glu Glu Asp  Glu Cys Gln 
    1625                 1630                 1635             


Asp Glu  Glu Asn Gln Lys Gln  Cys Gln Asp Leu Gly  Ala Phe Thr 
    1640                 1645                 1650             


Glu Ser  Met Val Val Phe Gly  Cys Pro Asn 
    1655                 1660             


<210>  11
<211>  708
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Asn Pro Thr Glu Thr Lys Ala Ile Pro Val Ser Gln Gln Met Glu 
1               5                   10                  15      


Gly Pro His Leu Pro Asn Lys Lys Lys His Lys Lys Gln Ala Val Lys 
            20                  25                  30          


Thr Glu Pro Glu Lys Lys Ser Gln Ser Thr Lys Leu Ser Val Val His 
        35                  40                  45              


Glu Lys Lys Ser Gln Glu Gly Lys Pro Lys Glu His Thr Glu Pro Lys 
    50                  55                  60                  


Ser Leu Pro Lys Gln Ala Ser Asp Thr Gly Ser Asn Asp Ala His Asn 
65                  70                  75                  80  


Lys Lys Ala Val Ser Arg Ser Ala Glu Gln Gln Pro Ser Glu Lys Ser 
                85                  90                  95      


Thr Glu Pro Lys Thr Lys Pro Gln Asp Met Ile Ser Ala Gly Gly Glu 
            100                 105                 110         


Ser Val Ala Gly Ile Thr Ala Ile Ser Gly Lys Pro Gly Asp Lys Lys 
        115                 120                 125             


Lys Glu Lys Lys Ser Leu Thr Pro Ala Val Pro Val Glu Ser Lys Pro 
    130                 135                 140                 


Asp Lys Pro Ser Gly Lys Ser Gly Met Asp Ala Ala Leu Asp Asp Leu 
145                 150                 155                 160 


Ile Asp Thr Leu Gly Gly Pro Glu Glu Thr Glu Glu Glu Asn Thr Thr 
                165                 170                 175     


Tyr Thr Gly Pro Glu Val Ser Asp Pro Met Ser Ser Thr Tyr Ile Glu 
            180                 185                 190         


Glu Leu Gly Lys Arg Glu Val Thr Ile Pro Pro Lys Tyr Arg Glu Leu 
        195                 200                 205             


Leu Ala Lys Lys Glu Gly Ile Thr Gly Pro Pro Ala Asp Ser Ser Lys 
    210                 215                 220                 


Pro Ile Gly Pro Asp Asp Ala Ile Asp Ala Leu Ser Ser Asp Phe Thr 
225                 230                 235                 240 


Cys Gly Ser Pro Thr Ala Ala Gly Lys Lys Thr Glu Lys Glu Glu Ser 
                245                 250                 255     


Thr Glu Val Leu Lys Ala Gln Ser Ala Gly Thr Val Arg Ser Ala Ala 
            260                 265                 270         


Pro Pro Gln Glu Lys Lys Arg Lys Val Glu Lys Asp Thr Met Ser Asp 
        275                 280                 285             


Gln Ala Leu Glu Ala Leu Ser Ala Ser Leu Gly Thr Arg Gln Ala Glu 
    290                 295                 300                 


Pro Glu Leu Asp Leu Arg Ser Ile Lys Glu Val Asp Glu Ala Lys Ala 
305                 310                 315                 320 


Lys Glu Glu Lys Leu Glu Lys Cys Gly Glu Asp Asp Glu Thr Ile Pro 
                325                 330                 335     


Ser Glu Tyr Arg Leu Lys Pro Ala Thr Asp Lys Asp Gly Lys Pro Leu 
            340                 345                 350         


Leu Pro Glu Pro Glu Glu Lys Pro Lys Pro Arg Ser Glu Ser Glu Leu 
        355                 360                 365             


Ile Asp Glu Leu Ser Glu Asp Phe Asp Arg Ser Glu Cys Lys Glu Lys 
    370                 375                 380                 


Pro Ser Lys Pro Thr Glu Lys Thr Glu Glu Ser Lys Ala Ala Ala Pro 
385                 390                 395                 400 


Ala Pro Val Ser Glu Ala Val Cys Arg Thr Ser Met Cys Ser Ile Gln 
                405                 410                 415     


Ser Ala Pro Pro Glu Pro Ala Thr Leu Lys Gly Thr Val Pro Asp Asp 
            420                 425                 430         


Ala Val Glu Ala Leu Ala Asp Ser Leu Gly Lys Lys Glu Ala Asp Pro 
        435                 440                 445             


Glu Asp Gly Lys Pro Val Met Asp Lys Val Lys Glu Lys Ala Lys Glu 
    450                 455                 460                 


Glu Asp Arg Glu Lys Leu Gly Glu Lys Glu Glu Thr Ile Pro Pro Asp 
465                 470                 475                 480 


Tyr Arg Leu Glu Glu Val Lys Asp Lys Asp Gly Lys Pro Leu Leu Pro 
                485                 490                 495     


Lys Glu Ser Lys Glu Gln Leu Pro Pro Met Ser Glu Asp Phe Leu Leu 
            500                 505                 510         


Asp Ala Leu Ser Glu Asp Phe Ser Gly Pro Gln Asn Ala Ser Ser Leu 
        515                 520                 525             


Lys Phe Glu Asp Ala Lys Leu Ala Ala Ala Ile Ser Glu Val Val Ser 
    530                 535                 540                 


Gln Thr Pro Ala Ser Thr Thr Gln Ala Gly Ala Pro Pro Arg Asp Thr 
545                 550                 555                 560 


Ser Gln Ser Asp Lys Asp Leu Asp Asp Ala Leu Asp Lys Leu Ser Asp 
                565                 570                 575     


Ser Leu Gly Gln Arg Gln Pro Asp Pro Asp Glu Asn Lys Pro Met Glu 
            580                 585                 590         


Asp Lys Val Lys Glu Lys Ala Lys Ala Glu His Arg Asp Lys Leu Gly 
        595                 600                 605             


Glu Arg Asp Asp Thr Ile Pro Pro Glu Tyr Arg His Leu Leu Asp Asp 
    610                 615                 620                 


Asn Gly Gln Asp Lys Pro Val Lys Pro Pro Thr Lys Lys Ser Glu Asp 
625                 630                 635                 640 


Ser Lys Lys Pro Ala Asp Asp Gln Asp Pro Ile Asp Ala Leu Ser Gly 
                645                 650                 655     


Asp Leu Asp Ser Cys Pro Ser Thr Thr Glu Thr Ser Gln Asn Thr Ala 
            660                 665                 670         


Lys Asp Lys Cys Lys Lys Ala Ala Ser Ser Ser Lys Ala Pro Lys Asn 
        675                 680                 685             


Gly Gly Lys Ala Lys Asp Ser Ala Lys Thr Thr Glu Glu Thr Ser Lys 
    690                 695                 700                 


Pro Lys Asp Asp 
705             


<210>  12
<211>  430
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Gly Gln Phe Leu Ser Ser Thr Phe Leu Glu Gly Ser Pro Ala Thr 
1               5                   10                  15      


Val Trp His Asp Lys Leu Cys Asp Gly Glu Arg Arg Gly Ala Arg Glu 
            20                  25                  30          


Ala Val Arg Ile Phe Gln Asp Gln Ala Lys Ala Lys Glu Glu Lys Leu 
        35                  40                  45              


Glu Lys Cys Gly Glu Asp Asp Glu Thr Ile Pro Ser Glu Tyr Arg Leu 
    50                  55                  60                  


Lys Pro Ala Thr Asp Lys Asp Gly Lys Pro Leu Leu Pro Glu Pro Glu 
65                  70                  75                  80  


Glu Lys Pro Lys Pro Arg Ser Glu Ser Glu Leu Ile Asp Glu Leu Ser 
                85                  90                  95      


Glu Asp Phe Asp Arg Ser Glu Cys Lys Glu Lys Pro Ser Lys Pro Thr 
            100                 105                 110         


Glu Lys Thr Glu Glu Ser Lys Ala Ala Ala Pro Ala Pro Val Ser Glu 
        115                 120                 125             


Ala Val Cys Arg Thr Ser Met Cys Ser Ile Gln Ser Ala Pro Pro Glu 
    130                 135                 140                 


Pro Ala Thr Leu Lys Gly Thr Val Pro Asp Asp Ala Val Glu Ala Leu 
145                 150                 155                 160 


Ala Asp Ser Leu Gly Lys Lys Glu Ala Asp Pro Glu Asp Gly Lys Pro 
                165                 170                 175     


Val Met Asp Lys Val Lys Glu Lys Ala Lys Glu Glu Asp Arg Glu Lys 
            180                 185                 190         


Leu Gly Glu Lys Glu Glu Thr Ile Pro Pro Asp Tyr Arg Leu Glu Glu 
        195                 200                 205             


Val Lys Asp Lys Asp Gly Lys Pro Leu Leu Pro Lys Glu Ser Lys Glu 
    210                 215                 220                 


Gln Leu Pro Pro Met Ser Glu Asp Phe Leu Leu Asp Ala Leu Ser Glu 
225                 230                 235                 240 


Asp Phe Ser Gly Pro Gln Asn Ala Ser Ser Leu Lys Phe Glu Asp Ala 
                245                 250                 255     


Lys Leu Ala Ala Ala Ile Ser Glu Val Val Ser Gln Thr Pro Ala Ser 
            260                 265                 270         


Thr Thr Gln Ala Gly Ala Pro Pro Arg Asp Thr Ser Ser Asp Lys Asp 
        275                 280                 285             


Leu Asp Asp Ala Leu Asp Lys Leu Ser Asp Ser Leu Gly Gln Arg Gln 
    290                 295                 300                 


Pro Asp Pro Asp Glu Asn Lys Pro Met Glu Asp Lys Val Lys Glu Lys 
305                 310                 315                 320 


Ala Lys Ala Glu His Arg Asp Lys Leu Gly Glu Arg Asp Asp Thr Ile 
                325                 330                 335     


Pro Pro Glu Tyr Arg His Leu Leu Asp Asp Asn Gly Gln Asp Lys Pro 
            340                 345                 350         


Val Lys Pro Pro Thr Lys Lys Ser Glu Asp Ser Lys Lys Pro Ala Asp 
        355                 360                 365             


Asp Gln Asp Pro Ile Asp Ala Leu Ser Gly Asp Leu Asp Ser Cys Pro 
    370                 375                 380                 


Ser Thr Thr Glu Thr Ser Gln Asn Thr Ala Lys Asp Lys Cys Lys Lys 
385                 390                 395                 400 


Ala Ala Ser Ser Ser Lys Ala Pro Lys Asn Gly Gly Lys Ala Lys Asp 
                405                 410                 415     


Ser Ala Lys Thr Thr Glu Glu Thr Ser Lys Pro Lys Asp Asp 
            420                 425                 430 


<210>  13
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ser Asp Gln Ala Leu Glu Ala Leu Ser Ala Ser Leu Gly Thr Arg 
1               5                   10                  15      


Gln Ala Glu Pro Glu Leu Asp Leu Arg Ser Ile Lys Glu Val Asp Glu 
            20                  25                  30          


Asp Lys Asp Gly Lys Pro Leu Leu Pro Glu Pro Glu Glu Lys Pro Lys 
        35                  40                  45              


Pro Arg Ser Glu Ser Glu Leu Ile Asp Glu Leu Ser Glu Asp Phe Asp 
    50                  55                  60                  


Arg Ser Glu Cys Lys Glu Lys Pro Ser Lys Pro Thr Glu Lys Thr Glu 
65                  70                  75                  80  


Glu Ser Lys Ala Ala Ala Pro Ala Pro Val Ser 
                85                  90      


<210>  14
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 
1               5                   10                  15      


Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys 
            20                  25                  30          


Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val 
        35                  40                  45              


Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys Glu Gln Val Thr 
    50                  55                  60                  


Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys 
65                  70                  75                  80  


Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys 
                85                  90                  95      


Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu Gly Ile 
            100                 105                 110         


Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro 
        115                 120                 125             


Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 
    130                 135                 140 


<210>  15
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 
1               5                   10                  15      


Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys 
            20                  25                  30          


Thr Lys Glu Gly Val Leu Tyr Val Val Ala Glu Lys Thr Lys Glu Gln 
        35                  40                  45              


Val Thr Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala 
    50                  55                  60                  


Gln Lys Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe 
65                  70                  75                  80  


Val Lys Lys Asp Gln Leu Gly Lys Glu Gly Tyr Gln Asp Tyr Glu Pro 
                85                  90                  95      


Glu Ala 
        


<210>  16
<211>  866
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Phe Ser Met Arg Ile Val Cys Leu Val Leu Ser Val Val Gly Thr 
1               5                   10                  15      


Ala Trp Thr Ala Asp Ser Gly Glu Gly Asp Phe Leu Ala Glu Gly Gly 
            20                  25                  30          


Gly Val Arg Gly Pro Arg Val Val Glu Arg His Gln Ser Ala Cys Lys 
        35                  40                  45              


Asp Ser Asp Trp Pro Phe Cys Ser Asp Glu Asp Trp Asn Tyr Lys Cys 
    50                  55                  60                  


Pro Ser Gly Cys Arg Met Lys Gly Leu Ile Asp Glu Val Asn Gln Asp 
65                  70                  75                  80  


Phe Thr Asn Arg Ile Asn Lys Leu Lys Asn Ser Leu Phe Glu Tyr Gln 
                85                  90                  95      


Lys Asn Asn Lys Asp Ser His Ser Leu Thr Thr Asn Ile Met Glu Ile 
            100                 105                 110         


Leu Arg Gly Asp Phe Ser Ser Ala Asn Asn Arg Asp Asn Thr Tyr Asn 
        115                 120                 125             


Arg Val Ser Glu Asp Leu Arg Ser Arg Ile Glu Val Leu Lys Arg Lys 
    130                 135                 140                 


Val Ile Glu Lys Val Gln His Ile Gln Leu Leu Gln Lys Asn Val Arg 
145                 150                 155                 160 


Ala Gln Leu Val Asp Met Lys Arg Leu Glu Val Asp Ile Asp Ile Lys 
                165                 170                 175     


Ile Arg Ser Cys Arg Gly Ser Cys Ser Arg Ala Leu Ala Arg Glu Val 
            180                 185                 190         


Asp Leu Lys Asp Tyr Glu Asp Gln Gln Lys Gln Leu Glu Gln Val Ile 
        195                 200                 205             


Ala Lys Asp Leu Leu Pro Ser Arg Asp Arg Gln His Leu Pro Leu Ile 
    210                 215                 220                 


Lys Met Lys Pro Val Pro Asp Leu Val Pro Gly Asn Phe Lys Ser Gln 
225                 230                 235                 240 


Leu Gln Lys Val Pro Pro Glu Trp Lys Ala Leu Thr Asp Met Pro Gln 
                245                 250                 255     


Met Arg Met Glu Leu Glu Arg Pro Gly Gly Asn Glu Ile Thr Arg Gly 
            260                 265                 270         


Gly Ser Thr Ser Tyr Gly Thr Gly Ser Glu Thr Glu Ser Pro Arg Asn 
        275                 280                 285             


Pro Ser Ser Ala Gly Ser Trp Asn Ser Gly Ser Ser Gly Pro Gly Ser 
    290                 295                 300                 


Thr Gly Asn Arg Asn Pro Gly Ser Ser Gly Thr Gly Gly Thr Ala Thr 
305                 310                 315                 320 


Trp Lys Pro Gly Ser Ser Gly Pro Gly Ser Thr Gly Ser Trp Asn Ser 
                325                 330                 335     


Gly Ser Ser Gly Thr Gly Ser Thr Gly Asn Gln Asn Pro Gly Ser Pro 
            340                 345                 350         


Arg Pro Gly Ser Thr Gly Thr Trp Asn Pro Gly Ser Ser Glu Arg Gly 
        355                 360                 365             


Ser Ala Gly His Trp Thr Ser Glu Ser Ser Val Ser Gly Ser Thr Gly 
    370                 375                 380                 


Gln Trp His Ser Glu Ser Gly Ser Phe Arg Pro Asp Ser Pro Gly Ser 
385                 390                 395                 400 


Gly Asn Ala Arg Pro Asn Asn Pro Asp Trp Gly Thr Phe Glu Glu Val 
                405                 410                 415     


Ser Gly Asn Val Ser Pro Gly Thr Arg Arg Glu Tyr His Thr Glu Lys 
            420                 425                 430         


Leu Val Thr Ser Lys Gly Asp Lys Glu Leu Arg Thr Gly Lys Glu Lys 
        435                 440                 445             


Val Thr Ser Gly Ser Thr Thr Thr Thr Arg Arg Ser Cys Ser Lys Thr 
    450                 455                 460                 


Val Thr Lys Thr Val Ile Gly Pro Asp Gly His Lys Glu Val Thr Lys 
465                 470                 475                 480 


Glu Val Val Thr Ser Glu Asp Gly Ser Asp Cys Pro Glu Ala Met Asp 
                485                 490                 495     


Leu Gly Thr Leu Ser Gly Ile Gly Thr Leu Asp Gly Phe Arg His Arg 
            500                 505                 510         


His Pro Asp Glu Ala Ala Phe Phe Asp Thr Ala Ser Thr Gly Lys Thr 
        515                 520                 525             


Phe Pro Gly Phe Phe Ser Pro Met Leu Gly Glu Phe Val Ser Glu Thr 
    530                 535                 540                 


Glu Ser Arg Gly Ser Glu Ser Gly Ile Phe Thr Asn Thr Lys Glu Ser 
545                 550                 555                 560 


Ser Ser His His Pro Gly Ile Ala Glu Phe Pro Ser Arg Gly Lys Ser 
                565                 570                 575     


Ser Ser Tyr Ser Lys Gln Phe Thr Ser Ser Thr Ser Tyr Asn Arg Gly 
            580                 585                 590         


Asp Ser Thr Phe Glu Ser Lys Ser Tyr Lys Met Ala Asp Glu Ala Gly 
        595                 600                 605             


Ser Glu Ala Asp His Glu Gly Thr His Ser Thr Lys Arg Gly His Ala 
    610                 615                 620                 


Lys Ser Arg Pro Val Arg Asp Cys Asp Asp Val Leu Gln Thr His Pro 
625                 630                 635                 640 


Ser Gly Thr Gln Ser Gly Ile Phe Asn Ile Lys Leu Pro Gly Ser Ser 
                645                 650                 655     


Lys Ile Phe Ser Val Tyr Cys Asp Gln Glu Thr Ser Leu Gly Gly Trp 
            660                 665                 670         


Leu Leu Ile Gln Gln Arg Met Asp Gly Ser Leu Asn Phe Asn Arg Thr 
        675                 680                 685             


Trp Gln Asp Tyr Lys Arg Gly Phe Gly Ser Leu Asn Asp Glu Gly Glu 
    690                 695                 700                 


Gly Glu Phe Trp Leu Gly Asn Asp Tyr Leu His Leu Leu Thr Gln Arg 
705                 710                 715                 720 


Gly Ser Val Leu Arg Val Glu Leu Glu Asp Trp Ala Gly Asn Glu Ala 
                725                 730                 735     


Tyr Ala Glu Tyr His Phe Arg Val Gly Ser Glu Ala Glu Gly Tyr Ala 
            740                 745                 750         


Leu Gln Val Ser Ser Tyr Glu Gly Thr Ala Gly Asp Ala Leu Ile Glu 
        755                 760                 765             


Gly Ser Val Glu Glu Gly Ala Glu Tyr Thr Ser His Asn Asn Met Gln 
    770                 775                 780                 


Phe Ser Thr Phe Asp Arg Asp Ala Asp Gln Trp Glu Glu Asn Cys Ala 
785                 790                 795                 800 


Glu Val Tyr Gly Gly Gly Trp Trp Tyr Asn Asn Cys Gln Ala Ala Asn 
                805                 810                 815     


Leu Asn Gly Ile Tyr Tyr Pro Gly Gly Ser Tyr Asp Pro Arg Asn Asn 
            820                 825                 830         


Ser Pro Tyr Glu Ile Glu Asn Gly Val Val Trp Val Ser Phe Arg Gly 
        835                 840                 845             


Ala Asp Tyr Ser Leu Arg Ala Val Arg Met Lys Ile Arg Pro Leu Val 
    850                 855                 860                 


Thr Gln 
865     


<210>  17
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Asp Asp Asp Ile Ala Ala Leu Val Val Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
            20                  25                  30          


Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 
        35                  40                  45              


Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 
    50                  55                  60                  


Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Val Thr Asn Trp Asp 
65                  70                  75                  80  


Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val 
                85                  90                  95      


Ala Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Leu Asn Pro 
            100                 105                 110         


Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe Asn 
        115                 120                 125             


Thr Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Ala 
    130                 135                 140                 


Ser Gly Arg Thr Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val Thr 
145                 150                 155                 160 


His Thr Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala Ile Leu 
                165                 170                 175     


Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met Lys Ile 
            180                 185                 190         


Leu Thr Glu Arg Gly Tyr Ser Phe Thr Thr Thr Ala Glu Arg Glu Ile 
        195                 200                 205             


Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe Glu 
    210                 215                 220                 


Gln Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys Ser Tyr 
225                 230                 235                 240 


Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe Arg 
                245                 250                 255     


Cys Pro Glu Ala Leu Phe Gln Pro Ser Phe Leu Gly Met Glu Ser Cys 
            260                 265                 270         


Gly Ile His Glu Thr Thr Phe Asn Ser Ile Met Lys Cys Asp Val Asp 
        275                 280                 285             


Ile Arg Lys Asp Leu Tyr Ala Asn Thr Val Leu Ser Gly Gly Thr Thr 
    290                 295                 300                 


Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr Ala Leu 
305                 310                 315                 320 


Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu Arg Lys 
                325                 330                 335     


Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser Thr Phe 
            340                 345                 350         


Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro Ser 
        355                 360                 365             


Ile Val His Arg Lys Cys Phe 
    370                 375 


<210>  18
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Glu Glu Glu Ile Ala Ala Leu Val Ile Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
            20                  25                  30          


Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 
        35                  40                  45              


Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 
    50                  55                  60                  


Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Val Thr Asn Trp Asp 
65                  70                  75                  80  


Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val 
                85                  90                  95      


Ala Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Leu Asn Pro 
            100                 105                 110         


Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe Asn 
        115                 120                 125             


Thr Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Ala 
    130                 135                 140                 


Ser Gly Arg Thr Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val Thr 
145                 150                 155                 160 


His Thr Val Pro 
                


<210>  19
<211>  1075
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Val Val Glu Val Asp Ser Met Pro Ala Ala Ser Ser Val Lys Lys 
1               5                   10                  15      


Pro Phe Gly Leu Arg Ser Lys Met Gly Lys Trp Cys Cys Arg Cys Phe 
            20                  25                  30          


Pro Cys Tyr Arg Glu Ser Gly Lys Ser Asn Val Gly Thr Ser Gly Asp 
        35                  40                  45              


His Asp Asp Ser Ala Met Lys Thr Leu Arg Ser Lys Met Gly Lys Trp 
    50                  55                  60                  


Cys His His Cys Phe Pro Cys Cys Arg Gly Ser Gly Lys Ser Asn Val 
65                  70                  75                  80  


Gly Ala Ser Gly Asp His Asp Asp Ser Ala Met Lys Thr Leu Arg Asn 
                85                  90                  95      


Lys Met Gly Lys Trp Cys Cys His Cys Phe Pro Cys Cys Arg Gly Ser 
            100                 105                 110         


Gly Lys Ser Lys Val Gly Ala Trp Gly Asp Tyr Asp Asp Ser Ala Phe 
        115                 120                 125             


Met Glu Pro Arg Tyr His Val Arg Gly Glu Asp Leu Asp Lys Leu His 
    130                 135                 140                 


Arg Ala Ala Trp Trp Gly Lys Val Pro Arg Lys Asp Leu Ile Val Met 
145                 150                 155                 160 


Leu Arg Asp Thr Asp Val Asn Lys Lys Asp Lys Gln Lys Arg Thr Ala 
                165                 170                 175     


Leu His Leu Ala Ser Ala Asn Gly Asn Ser Glu Val Val Lys Leu Leu 
            180                 185                 190         


Leu Asp Arg Arg Cys Gln Leu Asn Val Leu Asp Asn Lys Lys Arg Thr 
        195                 200                 205             


Ala Leu Ile Lys Ala Val Gln Cys Gln Glu Asp Glu Cys Ala Leu Met 
    210                 215                 220                 


Leu Leu Glu His Gly Thr Asp Pro Asn Ile Pro Asp Glu Tyr Gly Asn 
225                 230                 235                 240 


Thr Thr Leu His Tyr Ala Ile Tyr Asn Glu Asp Lys Leu Met Ala Lys 
                245                 250                 255     


Ala Leu Leu Leu Tyr Gly Ala Asp Ile Glu Ser Lys Asn Lys His Gly 
            260                 265                 270         


Leu Thr Pro Leu Leu Leu Gly Val His Glu Gln Lys Gln Gln Val Val 
        275                 280                 285             


Lys Phe Leu Ile Lys Lys Lys Ala Asn Leu Asn Ala Leu Asp Arg Tyr 
    290                 295                 300                 


Gly Arg Thr Ala Leu Ile Leu Ala Val Cys Cys Gly Ser Ala Ser Ile 
305                 310                 315                 320 


Val Ser Leu Leu Leu Glu Gln Asn Ile Asp Val Ser Ser Gln Asp Leu 
                325                 330                 335     


Ser Gly Gln Thr Ala Arg Glu Tyr Ala Val Ser Ser His His His Val 
            340                 345                 350         


Ile Cys Gln Leu Leu Ser Asp Tyr Lys Glu Lys Gln Met Leu Lys Ile 
        355                 360                 365             


Ser Ser Glu Asn Ser Asn Pro Glu Gln Glu Leu Lys Leu Thr Ser Glu 
    370                 375                 380                 


Glu Glu Ser Gln Arg Phe Lys Gly Ser Glu Asn Ser Gln Pro Glu Lys 
385                 390                 395                 400 


Met Ser Gln Glu Leu Glu Ile Asn Lys Asp Gly Asp Arg Glu Val Glu 
                405                 410                 415     


Glu Glu Met Lys Lys His Glu Ser Asn Asn Val Gly Leu Leu Glu Asn 
            420                 425                 430         


Leu Thr Asn Gly Val Thr Ala Gly Asn Gly Asp Asn Gly Leu Ile Pro 
        435                 440                 445             


Gln Arg Lys Ser Arg Thr Pro Glu Asn Gln Gln Phe Pro Asp Asn Glu 
    450                 455                 460                 


Ser Glu Glu Tyr His Arg Ile Cys Glu Leu Leu Ser Asp Tyr Lys Glu 
465                 470                 475                 480 


Lys Gln Met Pro Lys Tyr Ser Ser Glu Asn Ser Asn Pro Glu Gln Asp 
                485                 490                 495     


Leu Lys Leu Thr Ser Glu Glu Glu Ser Gln Arg Leu Lys Gly Ser Glu 
            500                 505                 510         


Asn Gly Gln Pro Glu Lys Arg Ser Gln Glu Pro Glu Ile Asn Lys Asp 
        515                 520                 525             


Gly Asp Arg Glu Leu Glu Asn Phe Met Ala Ile Glu Glu Met Lys Lys 
    530                 535                 540                 


His Gly Ser Thr His Val Gly Phe Pro Glu Asn Leu Thr Asn Gly Ala 
545                 550                 555                 560 


Thr Ala Gly Asn Gly Asp Asp Gly Leu Ile Pro Pro Arg Lys Ser Arg 
                565                 570                 575     


Thr Pro Glu Ser Gln Gln Phe Pro Asp Thr Glu Asn Glu Glu Tyr His 
            580                 585                 590         


Ser Asp Glu Gln Asn Asp Thr Gln Lys Gln Phe Cys Glu Glu Gln Asn 
        595                 600                 605             


Thr Gly Ile Leu His Asp Glu Ile Leu Ile His Glu Glu Lys Gln Ile 
    610                 615                 620                 


Glu Val Val Glu Lys Met Asn Ser Glu Leu Ser Leu Ser Cys Lys Lys 
625                 630                 635                 640 


Glu Lys Asp Val Leu His Glu Asn Ser Thr Leu Arg Glu Glu Ile Ala 
                645                 650                 655     


Met Leu Arg Leu Glu Leu Asp Thr Met Lys His Gln Ser Gln Leu Arg 
            660                 665                 670         


Glu Lys Lys Tyr Leu Glu Asp Ile Glu Ser Val Lys Lys Lys Asn Asp 
        675                 680                 685             


Asn Leu Leu Lys Ala Leu Gln Leu Asn Glu Leu Thr Met Asp Asp Asp 
    690                 695                 700                 


Thr Ala Val Leu Val Ile Asp Asn Gly Ser Gly Met Cys Lys Ala Gly 
705                 710                 715                 720 


Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro Ser Ile Val Gly 
                725                 730                 735     


Arg Pro Arg Gln Gln Gly Met Met Gly Gly Met His Gln Lys Glu Ser 
            740                 745                 750         


Tyr Val Gly Lys Glu Ala Gln Ser Lys Arg Gly Ile Leu Thr Leu Lys 
        755                 760                 765             


Tyr Pro Met Glu His Gly Ile Ile Thr Asn Trp Asp Asp Met Glu Lys 
    770                 775                 780                 


Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val Ala Pro Glu Glu 
785                 790                 795                 800 


His Pro Ile Leu Leu Thr Glu Ala Pro Leu Asn Pro Lys Ala Asn Arg 
                805                 810                 815     


Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe Asn Thr Pro Ala Met 
            820                 825                 830         


Tyr Val Ala Ile Gln Ala Val Pro Ser Leu Tyr Thr Ser Gly Arg Thr 
        835                 840                 845             


Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val Thr His Thr Val Pro 
    850                 855                 860                 


Ile Tyr Glu Gly Asn Ala Leu Pro His Ala Thr Leu Arg Leu Asp Leu 
865                 870                 875                 880 


Ala Gly Arg Glu Leu Pro Asp Tyr Leu Met Lys Ile Leu Thr Glu Arg 
                885                 890                 895     


Gly Tyr Arg Phe Thr Thr Met Ala Glu Arg Glu Ile Val Arg Asp Ile 
            900                 905                 910         


Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe Glu Gln Glu Met Ala 
        915                 920                 925             


Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys Ser Tyr Glu Leu Pro Asp 
    930                 935                 940                 


Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe Arg Cys Pro Glu Ala 
945                 950                 955                 960 


Leu Phe Gln Pro Cys Phe Leu Gly Met Glu Ser Cys Gly Ile His Glu 
                965                 970                 975     


Thr Thr Phe Asn Ser Ile Met Lys Ser Asp Val Asp Ile Arg Lys Asp 
            980                 985                 990         


Leu Tyr Thr Asn Thr Val Leu Ser  Gly Gly Thr Thr Met  Tyr Pro Gly 
        995                 1000                 1005             


Met Ala  His Arg Met Gln Lys  Glu Ile Ala Ala Leu  Ala Pro Ser 
    1010                 1015                 1020             


Met Met  Lys Ile Arg Ile Ile  Ala Pro Pro Lys Arg  Lys Tyr Ser 
    1025                 1030                 1035             


Val Trp  Val Gly Gly Ser Ile  Leu Ala Ser Leu Ser  Thr Phe Gln 
    1040                 1045                 1050             


Gln Met  Trp Ile Ser Lys Gln  Glu Tyr Asp Glu Ser  Gly Pro Ser 
    1055                 1060                 1065             


Ile Val  His Arg Lys Cys Phe  
    1070                 1075 


<210>  20
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ser Asp Lys Pro Asp Met Ala Glu Ile Glu Lys Phe Asp Lys Ser 
1               5                   10                  15      


Lys Leu Lys Lys Thr Glu Thr Gln Glu Lys Asn Pro Leu Pro Ser Lys 
            20                  25                  30          


Glu Thr Ile Glu Gln Glu Lys Gln Ala Gly Glu Ser 
        35                  40                  


<210>  21
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Asp Lys Pro Asp Met Gly Glu Ile Ala Ser Phe Asp Lys Ala 
1               5                   10                  15      


Lys Leu Lys Lys Thr Glu Thr Gln Glu Lys Asn Thr Leu Pro Thr Lys 
            20                  25                  30          


Glu Thr Ile Glu Gln Glu Lys Arg Ser Glu Ile Ser 
        35                  40                  


<210>  22
<211>  572
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Ala Pro Arg Pro Ser Pro Ala Ile Ser Val Ser Val Ser Ala 
1               5                   10                  15      


Pro Ala Phe Tyr Ala Pro Gln Lys Lys Phe Gly Pro Val Val Ala Pro 
            20                  25                  30          


Lys Pro Lys Val Asn Pro Phe Arg Pro Gly Asp Ser Glu Pro Pro Pro 
        35                  40                  45              


Ala Pro Gly Ala Gln Arg Ala Gln Met Gly Arg Val Gly Glu Ile Pro 
    50                  55                  60                  


Pro Pro Pro Pro Glu Asp Phe Pro Leu Pro Pro Pro Pro Leu Ala Gly 
65                  70                  75                  80  


Asp Gly Asp Asp Ala Glu Gly Ala Leu Gly Gly Ala Phe Pro Pro Pro 
                85                  90                  95      


Pro Pro Pro Ile Glu Glu Ser Phe Pro Pro Ala Pro Leu Glu Glu Glu 
            100                 105                 110         


Ile Phe Pro Ser Pro Pro Pro Pro Pro Glu Glu Glu Gly Gly Pro Glu 
        115                 120                 125             


Ala Pro Ile Pro Pro Pro Pro Gln Pro Arg Glu Lys Val Ser Ser Ile 
    130                 135                 140                 


Asp Leu Glu Ile Asp Ser Leu Ser Ser Leu Leu Asp Asp Met Thr Lys 
145                 150                 155                 160 


Asn Asp Pro Phe Lys Ala Arg Val Ser Ser Gly Tyr Val Pro Pro Pro 
                165                 170                 175     


Val Ala Thr Pro Phe Ser Ser Lys Ser Ser Thr Lys Pro Ala Ala Gly 
            180                 185                 190         


Gly Thr Ala Pro Leu Pro Pro Trp Lys Ser Pro Ser Ser Ser Gln Pro 
        195                 200                 205             


Leu Pro Gln Val Pro Ala Pro Ala Gln Ser Gln Thr Gln Phe His Val 
    210                 215                 220                 


Gln Pro Gln Pro Gln Pro Lys Pro Gln Val Gln Leu His Val Gln Ser 
225                 230                 235                 240 


Gln Thr Gln Pro Val Ser Leu Ala Asn Thr Gln Pro Arg Gly Pro Pro 
                245                 250                 255     


Ala Ser Ser Pro Ala Pro Ala Pro Lys Phe Ser Pro Val Thr Pro Lys 
            260                 265                 270         


Phe Thr Pro Val Ala Ser Lys Phe Ser Pro Gly Ala Pro Gly Gly Ser 
        275                 280                 285             


Gly Ser Gln Pro Asn Gln Lys Leu Gly His Pro Glu Ala Leu Ser Ala 
    290                 295                 300                 


Gly Thr Gly Ser Pro Gln Pro Pro Ser Phe Thr Tyr Ala Gln Gln Arg 
305                 310                 315                 320 


Glu Lys Pro Arg Val Gln Glu Lys Gln His Pro Val Pro Pro Pro Ala 
                325                 330                 335     


Gln Asn Gln Asn Gln Val Arg Ser Pro Gly Ala Pro Gly Pro Leu Thr 
            340                 345                 350         


Leu Lys Glu Val Glu Glu Leu Glu Gln Leu Thr Gln Gln Leu Met Gln 
        355                 360                 365             


Asp Met Glu His Pro Gln Arg Gln Asn Val Ala Val Asn Glu Leu Cys 
    370                 375                 380                 


Gly Arg Cys His Gln Pro Leu Ala Arg Ala Gln Pro Ala Val Arg Ala 
385                 390                 395                 400 


Leu Gly Gln Leu Phe His Ile Ala Cys Phe Thr Cys His Gln Cys Ala 
                405                 410                 415     


Gln Gln Leu Gln Gly Gln Gln Phe Tyr Ser Leu Glu Gly Ala Pro Tyr 
            420                 425                 430         


Cys Glu Gly Cys Tyr Thr Asp Thr Leu Glu Lys Cys Asn Thr Cys Gly 
        435                 440                 445             


Glu Pro Ile Thr Asp Arg Met Leu Arg Ala Thr Gly Lys Ala Tyr His 
    450                 455                 460                 


Pro His Cys Phe Thr Cys Val Val Cys Ala Arg Pro Leu Glu Gly Thr 
465                 470                 475                 480 


Ser Phe Ile Val Asp Gln Ala Asn Arg Pro His Cys Val Pro Asp Tyr 
                485                 490                 495     


His Lys Gln Tyr Ala Pro Arg Cys Ser Val Cys Ser Glu Pro Ile Met 
            500                 505                 510         


Pro Glu Pro Gly Arg Asp Glu Thr Val Arg Val Val Ala Leu Asp Lys 
        515                 520                 525             


Asn Phe His Met Lys Cys Tyr Lys Cys Glu Asp Cys Gly Lys Pro Leu 
    530                 535                 540                 


Ser Ile Glu Ala Asp Asp Asn Gly Cys Phe Pro Leu Asp Gly His Val 
545                 550                 555                 560 


Leu Cys Arg Lys Cys His Thr Ala Arg Ala Gln Thr 
                565                 570         


