                         SEQUENCE LISTING

<110>  MaavRx Ltd
 
<120>  Expression Vector

<130>  98015PCT1

<150>  2019286.0
<151>  2020-12-08

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  1494
<212>  DNA
<213>  Homo sapiens

<400>  1
atgcccaccc ccgacgccac cacgccacag gccaagggct tccgcagggc cgtgtctgag       60

ctggacgcca agcaggcaga ggccatcatg tccccgcggt tcattgggcg caggcagagc      120

ctcatcgagg acgcccgcaa ggagcgggag gcggcggtgg cagcagcggc cgctgcagtc      180

ccctcggagc ccggggaccc cctggaggct gtggcctttg aggagaagga ggggaaggcc      240

gtgctaaacc tgctcttctc cccgagggcc accaagccct cggcgctgtc ccgagctgtg      300

aaggtgtttg agacgtttga agccaaaatc caccatctag agacccggcc cgcccagagg      360

ccgcgagctg ggggccccca cctggagtac ttcgtgcgcc tcgaggtgcg ccgaggggac      420

ctggccgccc tgctcagtgg tgtgcgccag gtgtcagagg acgtgcgcag ccccgcgggg      480

cccaaggtcc cctggttccc aagaaaagtg tcagagctgg acaagtgtca tcacctggtc      540

accaagttcg accctgacct ggacttggac cacccgggct tctcggacca ggtgtaccgc      600

cagcgcagga agctgattgc tgagatcgcc ttccagtaca ggcacggcga cccgattccc      660

cgtgtggagt acaccgccga ggagattgcc acctggaagg aggtctacac cacgctgaag      720

ggcctctacg ccacgcacgc ctgcggggag cacctggagg cctttgcttt gctggagcgc      780

ttcagcggct accgggaaga caatatcccc cagctggagg acgtctcccg cttcctgaag      840

gagcgcacgg gcttccagct gcggcctgtg gccggcctgc tgtccgcccg ggacttcctg      900

gccagcctgg ccttccgcgt gttccagtgc acccagtata tccgccacgc gtcctcgccc      960

atgcactccc ctgagccgga ctgctgccac gagctgctgg ggcacgtgcc catgctggcc     1020

gaccgcacct tcgcgcagtt ctcgcaggac attggcctgg cgtccctggg ggcctcggat     1080

gaggaaattg agaagctgtc cacgctgtac tggttcacgg tggagttcgg gctgtgtaag     1140

cagaacgggg aggtgaaggc ctatggtgcc gggctgctgt cctcctacgg ggagctcctg     1200

cactgcctgt ctgaggagcc tgagattcgg gccttcgacc ctgaggctgc ggccgtgcag     1260

ccctaccaag accagacgta ccagtcagtc tacttcgtgt ctgagagctt cagtgacgcc     1320

aaggacaagc tcaggagcta tgcctcacgc atccagcgcc ccttctccgt gaagttcgac     1380

ccgtacacgc tggccatcga cgtgctggac agcccccagg ccgtgcggcg ctccctggag     1440

ggtgtccagg atgagctgga cacccttgcc catgcgctga gtgccattgg ctag           1494


<210>  2
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Thr Pro Asp Ala Thr Thr Pro Gln Ala Lys Gly Phe Arg Arg 
1               5                   10                  15      


Ala Val Ser Glu Leu Asp Ala Lys Gln Ala Glu Ala Ile Met Ser Pro 
            20                  25                  30          


Arg Phe Ile Gly Arg Arg Gln Ser Leu Ile Glu Asp Ala Arg Lys Glu 
        35                  40                  45              


Arg Glu Ala Ala Val Ala Ala Ala Ala Ala Ala Val Pro Ser Glu Pro 
    50                  55                  60                  


Gly Asp Pro Leu Glu Ala Val Ala Phe Glu Glu Lys Glu Gly Lys Ala 
65                  70                  75                  80  


Val Leu Asn Leu Leu Phe Ser Pro Arg Ala Thr Lys Pro Ser Ala Leu 
                85                  90                  95      


Ser Arg Ala Val Lys Val Phe Glu Thr Phe Glu Ala Lys Ile His His 
            100                 105                 110         


Leu Glu Thr Arg Pro Ala Gln Arg Pro Arg Ala Gly Gly Pro His Leu 
        115                 120                 125             


Glu Tyr Phe Val Arg Leu Glu Val Arg Arg Gly Asp Leu Ala Ala Leu 
    130                 135                 140                 


Leu Ser Gly Val Arg Gln Val Ser Glu Asp Val Arg Ser Pro Ala Gly 
145                 150                 155                 160 


Pro Lys Val Pro Trp Phe Pro Arg Lys Val Ser Glu Leu Asp Lys Cys 
                165                 170                 175     


His His Leu Val Thr Lys Phe Asp Pro Asp Leu Asp Leu Asp His Pro 
            180                 185                 190         


Gly Phe Ser Asp Gln Val Tyr Arg Gln Arg Arg Lys Leu Ile Ala Glu 
        195                 200                 205             


Ile Ala Phe Gln Tyr Arg His Gly Asp Pro Ile Pro Arg Val Glu Tyr 
    210                 215                 220                 


Thr Ala Glu Glu Ile Ala Thr Trp Lys Glu Val Tyr Thr Thr Leu Lys 
225                 230                 235                 240 


Gly Leu Tyr Ala Thr His Ala Cys Gly Glu His Leu Glu Ala Phe Ala 
                245                 250                 255     


Leu Leu Glu Arg Phe Ser Gly Tyr Arg Glu Asp Asn Ile Pro Gln Leu 
            260                 265                 270         


Glu Asp Val Ser Arg Phe Leu Lys Glu Arg Thr Gly Phe Gln Leu Arg 
        275                 280                 285             


Pro Val Ala Gly Leu Leu Ser Ala Arg Asp Phe Leu Ala Ser Leu Ala 
    290                 295                 300                 


Phe Arg Val Phe Gln Cys Thr Gln Tyr Ile Arg His Ala Ser Ser Pro 
305                 310                 315                 320 


Met His Ser Pro Glu Pro Asp Cys Cys His Glu Leu Leu Gly His Val 
                325                 330                 335     


Pro Met Leu Ala Asp Arg Thr Phe Ala Gln Phe Ser Gln Asp Ile Gly 
            340                 345                 350         


Leu Ala Ser Leu Gly Ala Ser Asp Glu Glu Ile Glu Lys Leu Ser Thr 
        355                 360                 365             


Leu Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Gln Asn Gly Glu 
    370                 375                 380                 


Val Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser Tyr Gly Glu Leu Leu 
385                 390                 395                 400 


His Cys Leu Ser Glu Glu Pro Glu Ile Arg Ala Phe Asp Pro Glu Ala 
                405                 410                 415     


Ala Ala Val Gln Pro Tyr Gln Asp Gln Thr Tyr Gln Ser Val Tyr Phe 
            420                 425                 430         


Val Ser Glu Ser Phe Ser Asp Ala Lys Asp Lys Leu Arg Ser Tyr Ala 
        435                 440                 445             


Ser Arg Ile Gln Arg Pro Phe Ser Val Lys Phe Asp Pro Tyr Thr Leu 
    450                 455                 460                 


Ala Ile Asp Val Leu Asp Ser Pro Gln Ala Val Arg Arg Ser Leu Glu 
465                 470                 475                 480 


Gly Val Gln Asp Glu Leu Asp Thr Leu Ala His Ala Leu Ser Ala Ile 
                485                 490                 495     


Gly 
    


<210>  3
<211>  1029
<212>  DNA
<213>  Homo sapiens

<400>  3
atgagccccg cggggcccaa ggtcccctgg ttcccaagaa aagtgtcaga gctggacaag       60

tgtcatcacc tggtcaccaa gttcgaccct gacctggact tggaccaccc gggcttctcg      120

gaccaggtgt accgccagcg caggaagctg attgctgaga tcgccttcca gtacaggcac      180

ggcgacccga ttccccgtgt ggagtacacc gccgaggaga ttgccacctg gaaggaggtc      240

tacaccacgc tgaagggcct ctacgccacg cacgcctgcg gggagcacct ggaggccttt      300

gctttgctgg agcgcttcag cggctaccgg gaagacaata tcccccagct ggaggacgtc      360

tcccgcttcc tgaaggagcg cacgggcttc cagctgcggc ctgtggccgg cctgctgtcc      420

gcccgggact tcctggccag cctggccttc cgcgtgttcc agtgcaccca gtatatccgc      480

cacgcgtcct cgcccatgca ctcccctgag ccggactgct gccacgagct gctggggcac      540

gtgcccatgc tggccgaccg caccttcgcg cagttctcgc aggacattgg cctggcgtcc      600

ctgggggcct cggatgagga aattgagaag ctgtccacgc tgtactggtt cacggtggag      660

ttcgggctgt gtaagcagaa cggggaggtg aaggcctatg gtgccgggct gctgtcctcc      720

tacggggagc tcctgcactg cctgtctgag gagcctgaga ttcgggcctt cgaccctgag      780

gctgcggccg tgcagcccta ccaagaccag acgtaccagt cagtctactt cgtgtctgag      840

agcttcagtg acgccaagga caagctcagg agctatgcct cacgcatcca gcgccccttc      900

tccgtgaagt tcgacccgta cacgctggcc atcgacgtgc tggacagccc ccaggccgtg      960

cggcgctccc tggagggtgt ccaggatgag ctggacaccc ttgcccatgc gctgagtgcc     1020

attggctag                                                             1029


<210>  4
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Pro Ala Gly Pro Lys Val Pro Trp Phe Pro Arg Lys Val Ser 
1               5                   10                  15      


Glu Leu Asp Lys Cys His His Leu Val Thr Lys Phe Asp Pro Asp Leu 
            20                  25                  30          


Asp Leu Asp His Pro Gly Phe Ser Asp Gln Val Tyr Arg Gln Arg Arg 
        35                  40                  45              


Lys Leu Ile Ala Glu Ile Ala Phe Gln Tyr Arg His Gly Asp Pro Ile 
    50                  55                  60                  


Pro Arg Val Glu Tyr Thr Ala Glu Glu Ile Ala Thr Trp Lys Glu Val 
65                  70                  75                  80  


Tyr Thr Thr Leu Lys Gly Leu Tyr Ala Thr His Ala Cys Gly Glu His 
                85                  90                  95      


Leu Glu Ala Phe Ala Leu Leu Glu Arg Phe Ser Gly Tyr Arg Glu Asp 
            100                 105                 110         


Asn Ile Pro Gln Leu Glu Asp Val Ser Arg Phe Leu Lys Glu Arg Thr 
        115                 120                 125             


Gly Phe Gln Leu Arg Pro Val Ala Gly Leu Leu Ser Ala Arg Asp Phe 
    130                 135                 140                 


Leu Ala Ser Leu Ala Phe Arg Val Phe Gln Cys Thr Gln Tyr Ile Arg 
145                 150                 155                 160 


His Ala Ser Ser Pro Met His Ser Pro Glu Pro Asp Cys Cys His Glu 
                165                 170                 175     


Leu Leu Gly His Val Pro Met Leu Ala Asp Arg Thr Phe Ala Gln Phe 
            180                 185                 190         


Ser Gln Asp Ile Gly Leu Ala Ser Leu Gly Ala Ser Asp Glu Glu Ile 
        195                 200                 205             


Glu Lys Leu Ser Thr Leu Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys 
    210                 215                 220                 


Lys Gln Asn Gly Glu Val Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser 
225                 230                 235                 240 


Tyr Gly Glu Leu Leu His Cys Leu Ser Glu Glu Pro Glu Ile Arg Ala 
                245                 250                 255     


Phe Asp Pro Glu Ala Ala Ala Val Gln Pro Tyr Gln Asp Gln Thr Tyr 
            260                 265                 270         


Gln Ser Val Tyr Phe Val Ser Glu Ser Phe Ser Asp Ala Lys Asp Lys 
        275                 280                 285             


Leu Arg Ser Tyr Ala Ser Arg Ile Gln Arg Pro Phe Ser Val Lys Phe 
    290                 295                 300                 


Asp Pro Tyr Thr Leu Ala Ile Asp Val Leu Asp Ser Pro Gln Ala Val 
305                 310                 315                 320 


Arg Arg Ser Leu Glu Gly Val Gln Asp Glu Leu Asp Thr Leu Ala His 
                325                 330                 335     


Ala Leu Ser Ala Ile Gly 
            340         


<210>  5
<211>  792
<212>  DNA
<213>  Mus musculus

<400>  5
ggtggttttc ctttgaaaaa cacgatgata atatggccac aaccgcggcc gtagatcccg       60

ggaccatgga gaagccgcgg ggagtcaggt gcaccaatgg gttctccgag cgggagctgc      120

cgcggcccgg ggccagcccg cctgccgaga agtcccggcc gcccgaggcc aagggcgcac      180

agccggccga cgcctggaag gcagggcggc accgcagcga ggaggaaaac caggtgaacc      240

tccccaaact ggcggctgct tactcgtcca ttctgctctc gctgggcgag gacccccagc      300

ggcaggggct gctcaagacg ccctggaggg cggccaccgc catgcagtac ttcaccaagg      360

gataccagga gaccatctca gatgtcctga atgatgctat atttgatgaa gatcatgacg      420

agatggtgat tgtgaaggac atagatatgt tctccatgtg tgagcatcac cttgttccat      480

ttgtaggaag ggtccatatt ggctatcttc ctaacaagca agtccttggt ctcagtaaac      540

ttgccaggat tgtagaaatc tacagtagac gactacaagt tcaagagcgc ctcaccaaac      600

agattgcggt ggccatcaca gaagccttgc agcctgctgg cgttggagta gtgattgaag      660

cgacacacat gtgcatggta atgcgaggcg tgcagaaaat gaacagcaag actgtcacta      720

gcaccatgct gggcgtgttc cgggaagacc ccaagactcg ggaggagttc ctcacactaa      780

tcaggagctg ag                                                          792


<210>  6
<211>  753
<212>  DNA
<213>  Homo sapiens

<400>  6
atggagaagg gccctgtgcg ggcaccggcg gagaagccgc ggggcgccag gtgcagcaat       60

gggttccccg agcgggatcc gccgcggccc gggcccagca ggccggcgga gaagcccccg      120

cggcccgagg ccaagagcgc gcagcccgcg gacggctgga agggcgagcg gccccgcagc      180

gaggaggata acgagctgaa cctccctaac ctggcagccg cctactcgtc catcctgagc      240

tcgctgggcg agaaccccca gcggcaaggg ctgctcaaga cgccctggag ggcggcctcg      300

gccatgcagt tcttcaccaa gggctaccag gagaccatct cagatgtcct aaacgatgct      360

atatttgatg aagatcatga tgagatggtg attgtgaagg acatagacat gttttccatg      420

tgtgagcatc acttggttcc atttgttgga aaggtccata ttggttatct tcctaacaag      480

caagtccttg gcctcagcaa acttgcgagg attgtagaaa tctatagtag aagactacaa      540

gttcaggagc gccttacaaa acaaattgct gtagcaatca cggaagcctt gcggcctgct      600

ggagtcgggg tagtggttga agcaacacac atgtgtatgg taatgcgagg tgtacagaaa      660

atgaacagca aaactgtgac cagcacaatg ttgggtgtgt tccgggagga tccaaagact      720

cgggaagagt tcctgactct cattaggagc tga                                   753


<210>  7
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Glu Lys Gly Pro Val Arg Ala Pro Ala Glu Lys Pro Arg Gly Ala 
1               5                   10                  15      


Arg Cys Ser Asn Gly Phe Pro Glu Arg Asp Pro Pro Arg Pro Gly Pro 
            20                  25                  30          


Ser Arg Pro Ala Glu Lys Pro Pro Arg Pro Glu Ala Lys Ser Ala Gln 
        35                  40                  45              


Pro Ala Asp Gly Trp Lys Gly Glu Arg Pro Arg Ser Glu Glu Asp Asn 
    50                  55                  60                  


Glu Leu Asn Leu Pro Asn Leu Ala Ala Ala Tyr Ser Ser Ile Leu Ser 
65                  70                  75                  80  


Ser Leu Gly Glu Asn Pro Gln Arg Gln Gly Leu Leu Lys Thr Pro Trp 
                85                  90                  95      


Arg Ala Ala Ser Ala Met Gln Phe Phe Thr Lys Gly Tyr Gln Glu Thr 
            100                 105                 110         


Ile Ser Asp Val Leu Asn Asp Ala Ile Phe Asp Glu Asp His Asp Glu 
        115                 120                 125             


Met Val Ile Val Lys Asp Ile Asp Met Phe Ser Met Cys Glu His His 
    130                 135                 140                 


Leu Val Pro Phe Val Gly Lys Val His Ile Gly Tyr Leu Pro Asn Lys 
145                 150                 155                 160 


Gln Val Leu Gly Leu Ser Lys Leu Ala Arg Ile Val Glu Ile Tyr Ser 
                165                 170                 175     


Arg Arg Leu Gln Val Gln Glu Arg Leu Thr Lys Gln Ile Ala Val Ala 
            180                 185                 190         


Ile Thr Glu Ala Leu Arg Pro Ala Gly Val Gly Val Val Val Glu Ala 
        195                 200                 205             


Thr His Met Cys Met Val Met Arg Gly Val Gln Lys Met Asn Ser Lys 
    210                 215                 220                 


Thr Val Thr Ser Thr Met Leu Gly Val Phe Arg Glu Asp Pro Lys Thr 
225                 230                 235                 240 


Arg Glu Glu Phe Leu Thr Leu Ile Arg Ser 
                245                 250 


<210>  8
<211>  798
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CBh promoter

<400>  8
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg      120

gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga      180

cgtcaatgac ggtaaatggc ccgcctggca ttgtgcccag tacatgacct tatgggactt      240

tcctacttgg cagtacatct acgtattagt catcgctatt accatggtcg aggtgagccc      300

cacgttctgc ttcactctcc ccatctcccc cccctcccca cccccaattt tgtatttatt      360

tattttttaa ttattttgtg cagcgatggg ggcggggggg gggggggggc gcgcgccagg      420

cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa      480

tcagagcggc gcgctccgaa agtttccttt tatggcgagg cggcggcggc ggcggcccta      540

taaaaagcga agcgcgcggc gggcgggagt cgctgcgcgc tgccttcgcc ccgtgccccg      600

ctccgccgcc gcctcgcgcc gcccgccccg gctctgactg accgcgttac tcccacaggt      660

gagcgggcgg gacggccctt ctcctccggg ctgtaattag ctgagcaaga ggtaagggtt      720

taagggatgg ttggttggtg gggtattaat gtttaattac ctggagcacc tgcctgaaat      780

cacttttttt caggttgg                                                    798


<210>  9
<211>  469
<212>  DNA
<213>  Homo sapiens

<400>  9
ctgcagaggg ccctgcgtat gagtgcaagt gggttttagg accaggatga ggcggggtgg       60

gggtgcctac ctgacgaccg accccgaccc actggacaag cacccaaccc ccattcccca      120

aattgcgcat cccctatcag agagggggag gggaaacagg atgcggcgag gcgcgtgcgc      180

actgccagct tcagcaccgc ggacagtgcc ttcgcccccg cctggcggcg cgcgccaccg      240

ccgcctcagc actgaaggcg cgctgacgtc actcgccggt cccccgcaaa ctccccttcc      300

cggccacctt ggtcgcgtcc gcgccgccgc cggcccagcc ggaccgcacc acgcgaggcg      360

cgagataggg gggcacgggc gcgaccatct gcgctgcggc gccggcgact cagcgctgcc      420

tcagtctgcg gtgggcagcg gaggagtcgt gtcgtgcctg agagcgcag                  469


<210>  10
<211>  659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chicken beta actin promoter with a cytomegalovirus enhancer (CB7)

<400>  10
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct      420

cccccccctc cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga      480

tgggggcggg gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg      540

gcggggcgag gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc      600

cttttatggc gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcg       659


<210>  11
<211>  663
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRE promoter

<400>  11
acgcgtggag ctagttatta atagtaatca attacggggt cattagttca tagcccatat       60

atggagttcc gcgttacata acttacggta aatggcccgc ctggctgacc gcccaacgac      120

ccccgcccat tgacgtcaat aatgacgtat gttcccatag taacgtcaat agggactttc      180

cattgacgtc aatgggtgga gtatttacgg taaactgccc acttggcagt acatcaagtg      240

tatcatatgc caagtacgcc ccctattgac gtcaatgacg gtaaatggcc cgcctggcat      300

tatgcccagt acatgacctt atgggacttt cctacttggc agtacatcta cgtattagtc      360

atcgctatta ccatggtgat gcggttttgg cagtacatca atgggcgtgg atagcggttt      420

gactcacggg gatttccaag tctccacccc attgacgtca atgggagttt gttttgcacc      480

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      540

gtaggcgtgt acggtgggag gtctatataa gcagagctcg tttagtgaac cgtcagatcg      600

cctggagacg ccatccacgc tgttttgacc tccatagaag acaccgggac cgatccagcc      660

tcc                                                                    663


<210>  12
<211>  592
<212>  DNA
<213>  Woodchuck hepatitis B virus

<400>  12
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt      120

atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg      180

tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact      240

ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct      300

attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg      360

ttgggcactg acaattccgt ggtgttgtcg gggaagctga cgtcctttcc atggctgctc      420

gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc      480

aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt      540

cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgcc tg              592


<210>  13
<211>  247
<212>  DNA
<213>  Woodchuck hepatitis B virus

<400>  13
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt      120

atggctttca ttttctcctc cttgtataaa tcctggttag ttcttgccac ggcggaactc      180

atcgccgcct gccttgcccg ctgctggaca ggggctcggc tgttgggcac tgacaattcc      240

gtggtgt                                                                247


<210>  14
<211>  224
<212>  DNA
<213>  Simian virus 40

<400>  14
agcagacatg ataagataca ttgatgagtt tggacaaacc acaactagaa tgcagtgaaa       60

aaaatgcttt atttgtgaaa tttgtgatgc tattgcttta tttgtaacca ttataagctg      120

caataaacaa gttaacaaca acaattgcat tcattttatg tttcaggttc agggggaggt      180

gtgggaggtt ttttaaagca agtaaaacct ctacaaatgt ggta                       224


<210>  15
<211>  208
<212>  DNA
<213>  Bos taurus

<400>  15
ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc       60

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc      120

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt      180

gggaagagaa tagcaggcat gctgggga                                         208


<210>  16
<211>  113
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ITR sequence

<400>  16
ccactccctc tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac       60

gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc gcgcagagag gga             113


<210>  17
<211>  5071
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Expression vector comprising a CBh promoter operably linked to an
       htTH coding sequence

<400>  17
agcgcccaat acgcaaaccg cctctccccg cgcgttggcc gattcattaa tgcagctggc       60

acgacaggtt tcccgactgg aaagcgggca gtgagcgcaa cgcaattaat gtgagttagc      120

tcactcatta ggcaccccag gctttacact ttatgcttcc ggctcgtatg ttgtgtggaa      180

ttgtgagcgg ataacaattt cacacaggaa acagctatga ccatgattac gccaagctct      240

cgagatctag aaagcttccc ggggggatct gggccactcc ctctctgcgc gctcgctcgc      300

tcactgaggc cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag      360

tgagcgagcg agcgcgcaga gagggagtgg ccaactccat cactaggggt tcctggaggg      420

gtggagtcgt gacctaggca actttgtata gaaaagttgc gttacataac ttacggtaaa      480

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaatag taacgccaat      540

agggactttc cattgacgtc aatgggtgga gtatttacgg taaactgccc acttggcagt      600

acatcaagtg tatcatatgc caagtacgcc ccctattgac gtcaatgacg gtaaatggcc      660

cgcctggcat tgtgcccagt acatgacctt atgggacttt cctacttggc agtacatcta      720

cgtattagtc atcgctatta ccatggtcga ggtgagcccc acgttctgct tcactctccc      780

catctccccc ccctccccac ccccaatttt gtatttattt attttttaat tattttgtgc      840

agcgatgggg gcgggggggg ggggggggcg cgcgccaggc ggggcggggc ggggcgaggg      900

gcggggcggg gcgaggcgga gaggtgcggc ggcagccaat cagagcggcg cgctccgaaa      960

gtttcctttt atggcgaggc ggcggcggcg gcggccctat aaaaagcgaa gcgcgcggcg     1020

ggcgggagtc gctgcgcgct gccttcgccc cgtgccccgc tccgccgccg cctcgcgccg     1080

cccgccccgg ctctgactga ccgcgttact cccacaggtg agcgggcggg acggcccttc     1140

tcctccgggc tgtaattagc tgagcaagag gtaagggttt aagggatggt tggttggtgg     1200

ggtattaatg tttaattacc tggagcacct gcctgaaatc actttttttc aggttggcaa     1260

gtttgtacag ccaccatgag ccccgcgggg cccaaggtcc cctggttccc aagaaaagtg     1320

tcagagctgg acaagtgtca tcacctggtc accaagttcg accctgacct ggacttggac     1380

cacccgggct tctcggacca ggtgtaccgc cagcgcagga agctgattgc tgagatcgcc     1440

ttccagtaca ggcacggcga cccgattccc cgtgtggagt acaccgccga ggagattgcc     1500

acctggaagg aggtctacac cacgctgaag ggcctctacg ccacgcacgc ctgcggggag     1560

cacctggagg cctttgcttt gctggagcgc ttcagcggct accgggaaga caatatcccc     1620

cagctggagg acgtctcccg cttcctgaag gagcgcacgg gcttccagct gcggcctgtg     1680

gccggcctgc tgtccgcccg ggacttcctg gccagcctgg ccttccgcgt gttccagtgc     1740

acccagtata tccgccacgc gtcctcgccc atgcactccc ctgagccgga ctgctgccac     1800

gagctgctgg ggcacgtgcc catgctggcc gaccgcacct tcgcgcagtt ctcgcaggac     1860

attggcctgg cgtccctggg ggcctcggat gaggaaattg agaagctgtc cacgctgtac     1920

tggttcacgg tggagttcgg gctgtgtaag cagaacgggg aggtgaaggc ctatggtgcc     1980

gggctgctgt cctcctacgg ggagctcctg cactgcctgt ctgaggagcc tgagattcgg     2040

gccttcgacc ctgaggctgc ggccgtgcag ccctaccaag accagacgta ccagtcagtc     2100

tacttcgtgt ctgagagctt cagtgacgcc aaggacaagc tcaggagcta tgcctcacgc     2160

atccagcgcc ccttctccgt gaagttcgac ccgtacacgc tggccatcga cgtgctggac     2220

agcccccagg ccgtgcggcg ctccctggag ggtgtccagg atgagctgga cacccttgcc     2280

catgcgctga gtgccattgg ctaacagaca tgataagata cattgatgag tttggacaaa     2340

ccacaactag aatgcagtga aaaaaatgct ttatttgtga aatttgtgat gctattgctt     2400

tatttgtaac cattataagc tgcaataaac aagttaacaa caacaattgc attcatttta     2460

tgtttcaggt tcagggggag gtgtgggagg ttttttaaag caagtaaaac ctctacaaat     2520

gtggtaacta gtccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa     2580

aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgcagag     2640

agggacagat ccgggcccgc atgcgtcgac aattcactgg ccgtcgtttt acaacgtcgt     2700

gactgggaaa accctggcgt tacccaactt aatcgccttg cagcacatcc ccctttcgcc     2760

agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg     2820

aatggcgaat ggcgcctgat gcggtatttt ctccttacgc atctgtgcgg tatttcacac     2880

cgcatatggt gcactctcag tacaatctgc tctgatgccg catagttaag ccagccccga     2940

cacccgccaa cacccgctga cgcgccctga cgggcttgtc tgctcccggc atccgcttac     3000

agacaagctg tgaccgtctc cgggagctgc atgtgtcaga ggttttcacc gtcatcaccg     3060

aaacgcgcga gacgaaaggg cctcgtgata cgcctatttt tataggttaa tgtcatgata     3120

ataatggttt cttagacgtc aggtggcact tttcggggaa atgtgcgcgg aacccctatt     3180

tgtttatttt tctaaataca ttcaaatatg tatccgctca tgagacaata accctgataa     3240

atgcttcaat aatattgaaa aaggaagagt atgagtattc aacatttccg tgtcgccctt     3300

attccctttt ttgcggcatt ttgccttcct gtttttgctc acccagaaac gctggtgaaa     3360

gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt acatcgaact ggatctcaac     3420

agcggtaaga tccttgagag ttttcgcccc gaagaacgtt ttccaatgat gagcactttt     3480

aaagttctgc tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga gcaactcggt     3540

cgccgcatac actattctca gaatgacttg gttgagtact caccagtcac agaaaagcat     3600

cttacggatg gcatgacagt aagagaatta tgcagtgctg ccataaccat gagtgataac     3660

actgcggcca acttacttct gacaacgatc ggaggaccga aggagctaac cgcttttttg     3720

cacaacatgg gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc     3780

ataccaaacg acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa     3840

ctattaactg gcgaactact tactctagct tcccggcaac aattaataga ctggatggag     3900

gcggataaag ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct     3960

gataaatctg gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat     4020

ggtaagccct cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa     4080

cgaaatagac agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac     4140

caagtttact catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc     4200

taggtgaaga tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc     4260

cactgagcgt cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg     4320

cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg     4380

gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca     4440

aatactgttc ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg     4500

cctacatacc tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg     4560

tgtcttaccg ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga     4620

acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac     4680

ctacagcgtg agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat     4740

ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc     4800

tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga     4860

tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc     4920

ctggcctttt gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg     4980

gataaccgta ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag     5040

cgcagcgagt cagtgagcga ggaagcggaa g                                    5071


<210>  18
<211>  4954
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Expression vector comprising a CBh promoter operably linked to a 
       GCH-1 coding sequence

<400>  18
agcgcccaat acgcaaaccg cctctccccg cgcgttggcc gattcattaa tgcagctggc       60

acgacaggtt tcccgactgg aaagcgggca gtgagcgcaa cgcaattaat gtgagttagc      120

tcactcatta ggcaccccag gctttacact ttatgcttcc ggctcgtatg ttgtgtggaa      180

ttgtgagcgg ataacaattt cacacaggaa acagctatga ccatgattac gccaagctct      240

cgagatctag aaagcttccc ggggggatct gggccactcc ctctctgcgc gctcgctcgc      300

tcactgaggc cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag      360

tgagcgagcg agcgcgcaga gagggagtgg ccaactccat cactaggggt tcctggaggg      420

gtggagtcgt gacctaggca actttgtata gaaaagttgc gttacataac ttacggtaaa      480

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaatag taacgccaat      540

agggactttc cattgacgtc aatgggtgga gtatttacgg taaactgccc acttggcagt      600

acatcaagtg tatcatatgc caagtacgcc ccctattgac gtcaatgacg gtaaatggcc      660

cgcctggcat tgtgcccagt acatgacctt atgggacttt cctacttggc agtacatcta      720

cgtattagtc atcgctatta ccatggtcga ggtgagcccc acgttctgct tcactctccc      780

catctccccc ccctccccac ccccaatttt gtatttattt attttttaat tattttgtgc      840

agcgatgggg gcgggggggg ggggggggcg cgcgccaggc ggggcggggc ggggcgaggg      900

gcggggcggg gcgaggcgga gaggtgcggc ggcagccaat cagagcggcg cgctccgaaa      960

gtttcctttt atggcgaggc ggcggcggcg gcggccctat aaaaagcgaa gcgcgcggcg     1020

ggcgggagtc gctgcgcgct gccttcgccc cgtgccccgc tccgccgccg cctcgcgccg     1080

cccgccccgg ctctgactga ccgcgttact cccacaggtg agcgggcggg acggcccttc     1140

tcctccgggc tgtaattagc tgagcaagag gtaagggttt aagggatggt tggttggtgg     1200

ggtattaatg tttaattacc tggagcacct gcctgaaatc actttttttc aggttggcaa     1260

gtttgtacag ccaccatgga gaagccgcgg ggtgtaaggt gcaccaatgg gttccccgag     1320

cgggagctgc cgcggcccgg ggccagccga cctgccgaga agtcccggcc gcccgaggcc     1380

aagggcgcac agccagccga cgcctggaag gcagggcggc cccgcagcga ggaggataac     1440

gagctgaacc tccccaacct ggcggccgct tactcgtcca tcctgcgctc gctgggcgag     1500

gacccccagc ggcaggggct gctcaagacg ccctggaggg cggccaccgc catgcagttc     1560

ttcaccaagg gataccagga gaccatctca gatgtcctga acgatgctat atttgatgag     1620

gaccatgacg agatggtgat tgtgaaggac attgacatgt tttccatgtg tgagcatcac     1680

ctggtcccat ttgtgggaag ggtccatatt ggttatcttc ctaacaagca agtccttggt     1740

ctcagcaaac ttgccaggat tgtggaaatc tacagtagaa gactacaagt tcaagaacgc     1800

cttaccaaac agattgcagt ggccatcaca gaagccttgc agcctgctgg cgtcggggta     1860

gtgattgaag caacacacat gtgtatggtc atgcgaggtg tgcagaaaat gaacagcaag     1920

actgtcacta gcaccatgct aggcgtgttc cgggaagacc caaagactcg ggaggagttc     1980

ctcacactca tcaggagctg aaatcaacct ctggattaca aaatttgtga aagattgact     2040

ggtattctta actatgttgc tccttttacg ctatgtggat acgctgcttt aatgcctttg     2100

tatcatgcta ttgcttcccg tatggctttc attttctcct ccttgtataa atcctggtta     2160

gttcttgcca cggcggaact catcgccgcc tgccttgccc gctgctggac aggggctcgg     2220

ctgttgggca ctgacaattc cgtggtgttt atttgtgaaa tttgtgatgc tattgcttta     2280

tttgtaacca tctagcttta tttgtgaaat ttgtgatgct attgctttat ttgtaaccat     2340

tataagctgc aataaacaag ttaacaacaa caattgcatt cattttatgt ttcaggttca     2400

gggggagaga ctagtccact ccctctctgc gcgctcgctc gctcactgag gccgggcgac     2460

caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc agtgagcgag cgagcgcgca     2520

gagagggaca gatccgggcc cgcatgcgtc gacaattcac tggccgtcgt tttacaacgt     2580

cgtgactggg aaaaccctgg cgttacccaa cttaatcgcc ttgcagcaca tccccctttc     2640

gccagctggc gtaatagcga agaggcccgc accgatcgcc cttcccaaca gttgcgcagc     2700

ctgaatggcg aatggcgcct gatgcggtat tttctcctta cgcatctgtg cggtatttca     2760

caccgcatat ggtgcactct cagtacaatc tgctctgatg ccgcatagtt aagccagccc     2820

cgacacccgc caacacccgc tgacgcgccc tgacgggctt gtctgctccc ggcatccgct     2880

tacagacaag ctgtgaccgt ctccgggagc tgcatgtgtc agaggttttc accgtcatca     2940

ccgaaacgcg cgagacgaaa gggcctcgtg atacgcctat ttttataggt taatgtcatg     3000

ataataatgg tttcttagac gtcaggtggc acttttcggg gaaatgtgcg cggaacccct     3060

atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga     3120

taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc     3180

cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg     3240

aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga actggatctc     3300

aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat gatgagcact     3360

tttaaagttc tgctatgtgg cgcggtatta tcccgtattg acgccgggca agagcaactc     3420

ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt cacagaaaag     3480

catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac catgagtgat     3540

aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct aaccgctttt     3600

ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa     3660

gccataccaa acgacgagcg tgacaccacg atgcctgtag caatggcaac aacgttgcgc     3720

aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat agactggatg     3780

gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg ctggtttatt     3840

gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc actggggcca     3900

gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc aactatggat     3960

gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg gtaactgtca     4020

gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta atttaaaagg     4080

atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg tgagttttcg     4140

ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt     4200

ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg     4260

ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata     4320

ccaaatactg ttcttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca     4380

ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag     4440

tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc     4500

tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga     4560

tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg     4620

tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac     4680

gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg     4740

tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg     4800

ttcctggcct tttgctggcc ttttgctcac atgttctttc ctgcgttatc ccctgattct     4860

gtggataacc gtattaccgc ctttgagtga gctgataccg ctcgccgcag ccgaacgacc     4920

gagcgcagcg agtcagtgag cgaggaagcg gaag                                 4954


<210>  19
<211>  4984
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Expression vector comprising a SYN1 promoter operably linked to 
       an htTH coding sequence

<400>  19
ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg       60

acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgcagag agggagtggc      120

caactccatc actaggggtt cctggagggg tggagtcgtg acctaggcaa ctttgtatag      180

aaaagttgct gcagagtgca agtgggtttt aggaccagga tgaggcgggg tgggggtgcc      240

tacctgacga ccgaccccga cccactggac aagcacccaa cccccattcc ccaaattgcg      300

catcccctat cagagagggg gaggggaaac aggatgcggc gaggcgcgtg cgcactgcca      360

gcttcagcac cgcggacagt gccttcgccc ccgcctggcg gcgcgcgcca ccgccgcctc      420

agcactgaag gcgcgctgac gtcactcgcc ggtcccccgc aaactcccct tcccggccac      480

cttggtcgcg tccgcgccgc cgccggccca gccggaccgc accacgcgag gcgcgagata      540

ggggggcacg ggcgcgacca tctgcgctgc ggcgccggcg actcagcgct gcctcagtct      600

gcggtgggca gcggaggagt cgtgtcgtgc ctgagagcgc aggccaccat gagccccgcg      660

gggcccaagg tcccctggtt cccaagaaaa gtgtcagagc tggacaagtg tcatcacctg      720

gtcaccaagt tcgaccctga cctggacttg gaccacccgg gcttctcgga ccaggtgtac      780

cgccagcgca ggaagctgat tgctgagatc gccttccagt acaggcacgg cgacccgatt      840

ccccgtgtgg agtacaccgc cgaggagatt gccacctgga aggaggtcta caccacgctg      900

aagggcctct acgccacgca cgcctgcggg gagcacctgg aggcctttgc tttgctggag      960

cgcttcagcg gctaccggga agacaatatc ccccagctgg aggacgtctc ccgcttcctg     1020

aaggagcgca cgggcttcca gctgcggcct gtggccggcc tgctgtccgc ccgggacttc     1080

ctggccagcc tggccttccg cgtgttccag tgcacccagt atatccgcca cgcgtcctcg     1140

cccatgcact cccctgagcc ggactgctgc cacgagctgc tggggcacgt gcccatgctg     1200

gccgaccgca ccttcgcgca gttctcgcag gacattggcc tggcgtccct gggggcctcg     1260

gatgaggaaa ttgagaagct gtccacgctg tactggttca cggtggagtt cgggctgtgt     1320

aagcagaacg gggaggtgaa ggcctatggt gccgggctgc tgtcctccta cggggagctc     1380

ctgcactgcc tgtctgagga gcctgagatt cgggccttcg accctgaggc tgcggccgtg     1440

cagccctacc aagaccagac gtaccagtca gtctacttcg tgtctgagag cttcagtgac     1500

gccaaggaca agctcaggag ctatgcctca cgcatccagc gccccttctc cgtgaagttc     1560

gacccgtaca cgctggccat cgacgtgctg gacagccccc aggccgtgcg gcgctccctg     1620

gagggtgtcc aggatgagct ggacaccctt gcccatgcgc tgagtgccat tggctaaaat     1680

caacctctgg attacaaaat ttgtgaaaga ttgactggta ttcttaacta tgttgctcct     1740

tttacgctat gtggatacgc tgctttaatg cctttgtatc atgctattgc ttcccgtatg     1800

gctttcattt tctcctcctt gtataaatcc tggttagttc ttgccacggc ggaactcatc     1860

gccgcctgcc ttgcccgctg ctggacaggg gctcggctgt tgggcactga caattccgtg     1920

gtgtttattt gtgaaatttg tgatgctatt gctttatttg taaccatcta gctttatttg     1980

tgaaatttgt gatgctattg ctttatttgt aaccattata agctgcaata aacaagttaa     2040

caacaacaat tgcattcatt ttatgtttca ggttcagggg gagagcaatt gcattcattt     2100

tatgtttcag gttcaggggg aggtgtggga ggttttttaa agcaagtaaa acctctacaa     2160

atgtggtaac tagtccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc     2220

aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag     2280

agagggacag atccgggccc gcatgcgtcg acaattcact ggccgtcgtt ttacaacgtc     2340

gtgactggga aaaccctggc gttacccaac ttaatcgcct tgcagcacat ccccctttcg     2400

ccagctggcg taatagcgaa gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc     2460

tgaatggcga atggcgcctg atgcggtatt ttctccttac gcatctgtgc ggtatttcac     2520

accgcatatg gtgcactctc agtacaatct gctctgatgc cgcatagtta agccagcccc     2580

gacacccgcc aacacccgct gacgcgccct gacgggcttg tctgctcccg gcatccgctt     2640

acagacaagc tgtgaccgtc tccgggagct gcatgtgtca gaggttttca ccgtcatcac     2700

cgaaacgcgc gagacgaaag ggcctcgtga tacgcctatt tttataggtt aatgtcatga     2760

taataatggt ttcttagacg tcaggtggca cttttcgggg aaatgtgcgc ggaaccccta     2820

tttgtttatt tttctaaata cattcaaata tgtatccgct catgagacaa taaccctgat     2880

aaatgcttca ataatattga aaaaggaaga gtatgagtat tcaacatttc cgtgtcgccc     2940

ttattccctt ttttgcggca ttttgccttc ctgtttttgc tcacccagaa acgctggtga     3000

aagtaaaaga tgctgaagat cagttgggtg cacgagtggg ttacatcgaa ctggatctca     3060

acagcggtaa gatccttgag agttttcgcc ccgaagaacg ttttccaatg atgagcactt     3120

ttaaagttct gctatgtggc gcggtattat cccgtattga cgccgggcaa gagcaactcg     3180

gtcgccgcat acactattct cagaatgact tggttgagta ctcaccagtc acagaaaagc     3240

atcttacgga tggcatgaca gtaagagaat tatgcagtgc tgccataacc atgagtgata     3300

acactgcggc caacttactt ctgacaacga tcggaggacc gaaggagcta accgcttttt     3360

tgcacaacat gggggatcat gtaactcgcc ttgatcgttg ggaaccggag ctgaatgaag     3420

ccataccaaa cgacgagcgt gacaccacga tgcctgtagc aatggcaaca acgttgcgca     3480

aactattaac tggcgaacta cttactctag cttcccggca acaattaata gactggatgg     3540

aggcggataa agttgcagga ccacttctgc gctcggccct tccggctggc tggtttattg     3600

ctgataaatc tggagccggt gagcgtgggt ctcgcggtat cattgcagca ctggggccag     3660

atggtaagcc ctcccgtatc gtagttatct acacgacggg gagtcaggca actatggatg     3720

aacgaaatag acagatcgct gagataggtg cctcactgat taagcattgg taactgtcag     3780

accaagttta ctcatatata ctttagattg atttaaaact tcatttttaa tttaaaagga     3840

tctaggtgaa gatccttttt gataatctca tgaccaaaat cccttaacgt gagttttcgt     3900

tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat cctttttttc     3960

tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg gtttgtttgc     4020

cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga gcgcagatac     4080

caaatactgt tcttctagtg tagccgtagt taggccacca cttcaagaac tctgtagcac     4140

cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt ggcgataagt     4200

cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag cggtcgggct     4260

gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc gaactgagat     4320

acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag gcggacaggt     4380

atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca gggggaaacg     4440

cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt cgatttttgt     4500

gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc tttttacggt     4560

tcctggcctt ttgctggcct tttgctcaca tgttctttcc tgcgttatcc cctgattctg     4620

tggataaccg tattaccgcc tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg     4680

agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc     4740

ccgcgcgttg gccgattcat taatgcagct ggcacgacag gtttcccgac tggaaagcgg     4800

gcagtgagcg caacgcaatt aatgtgagtt agctcactca ttaggcaccc caggctttac     4860

actttatgct tccggctcgt atgttgtgtg gaattgtgag cggataacaa tttcacacag     4920

gaaacagcta tgaccatgat tacgccaagc tctcgagatc tagaaagctt cccgggggga     4980

tctg                                                                  4984


<210>  20
<211>  4681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Expression vector comprising a SYN1 promoter operably linked to a
       GCH-1 coding sequence

<400>  20
ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg       60

acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgcagag agggagtggc      120

caactccatc actaggggtt cctggagggg tggagtcgtg acctaggcaa ctttgtatag      180

aaaagttgct gcagagtgca agtgggtttt aggaccagga tgaggcgggg tgggggtgcc      240

tacctgacga ccgaccccga cccactggac aagcacccaa cccccattcc ccaaattgcg      300

catcccctat cagagagggg gaggggaaac aggatgcggc gaggcgcgtg cgcactgcca      360

gcttcagcac cgcggacagt gccttcgccc ccgcctggcg gcgcgcgcca ccgccgcctc      420

agcactgaag gcgcgctgac gtcactcgcc ggtcccccgc aaactcccct tcccggccac      480

cttggtcgcg tccgcgccgc cgccggccca gccggaccgc accacgcgag gcgcgagata      540

ggggggcacg ggcgcgacca tctgcgctgc ggcgccggcg actcagcgct gcctcagtct      600

gcggtgggca gcggaggagt cgtgtcgtgc ctgagagcgc aggccaccat ggagaagccg      660

cggggtgtaa ggtgcaccaa tgggttcccc gagcgggagc tgccgcggcc cggggccagc      720

cgacctgccg agaagtcccg gccgcccgag gccaagggcg cacagccagc cgacgcctgg      780

aaggcagggc ggccccgcag cgaggaggat aacgagctga acctccccaa cctggcggcc      840

gcttactcgt ccatcctgcg ctcgctgggc gaggaccccc agcggcaggg gctgctcaag      900

acgccctgga gggcggccac cgccatgcag ttcttcacca agggatacca ggagaccatc      960

tcagatgtcc tgaacgatgc tatatttgat gaggaccatg acgagatggt gattgtgaag     1020

gacattgaca tgttttccat gtgtgagcat cacctggtcc catttgtggg aagggtccat     1080

attggttatc ttcctaacaa gcaagtcctt ggtctcagca aacttgccag gattgtggaa     1140

atctacagta gaagactaca agttcaagaa cgccttacca aacagattgc agtggccatc     1200

acagaagcct tgcagcctgc tggcgtcggg gtagtgattg aagcaacaca catgtgtatg     1260

gtcatgcgag gtgtgcagaa aatgaacagc aagactgtca ctagcaccat gctaggcgtg     1320

ttccgggaag acccaaagac tcgggaggag ttcctcacac tcatcaggag ctgaaatcaa     1380

cctctggatt acaaaatttg tgaaagattg actggtattc ttaactatgt tgctcctttt     1440

acgctatgtg gatacgctgc tttaatgcct ttgtatcatg ctattgcttc ccgtatggct     1500

ttcattttct cctccttgta taaatcctgg ttagttcttg ccacggcgga actcatcgcc     1560

gcctgccttg cccgctgctg gacaggggct cggctgttgg gcactgacaa ttccgtggtg     1620

tttatttgtg aaatttgtga tgctattgct ttatttgtaa ccatctagct ttatttgtga     1680

aatttgtgat gctattgctt tatttgtaac cattataagc tgcaataaac aagttaacaa     1740

caacaattgc attcatttta tgtttcaggt tcagggggag agcaattgca ttcattttat     1800

gtttcaggtt cagggggagg tgtgggaggt tttttaaagc aagtaaaacc tctacaaatg     1860

tggtaactag tccactccct ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa     1920

ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag cgcgcagaga     1980

gggacagatc cgggcccgca tgcgtcgaca attcactggc cgtcgtttta caacgtcgtg     2040

actgggaaaa ccctggcgtt acccaactta atcgccttgc agcacatccc cctttcgcca     2100

gctggcgtaa tagcgaagag gcccgcaccg atcgcccttc ccaacagttg cgcagcctga     2160

atggcgaatg gcgcctgatg cggtattttc tccttacgca tctgtgcggt atttcacacc     2220

gcatatggtg cactctcagt acaatctgct ctgatgccgc atagttaagc cagccccgac     2280

acccgccaac acccgctgac gcgccctgac gggcttgtct gctcccggca tccgcttaca     2340

gacaagctgt gaccgtctcc gggagctgca tgtgtcagag gttttcaccg tcatcaccga     2400

aacgcgcgag acgaaagggc ctcgtgatac gcctattttt ataggttaat gtcatgataa     2460

taatggtttc ttagacgtca ggtggcactt ttcggggaaa tgtgcgcgga acccctattt     2520

gtttattttt ctaaatacat tcaaatatgt atccgctcat gagacaataa ccctgataaa     2580

tgcttcaata atattgaaaa aggaagagta tgagtattca acatttccgt gtcgccctta     2640

ttcccttttt tgcggcattt tgccttcctg tttttgctca cccagaaacg ctggtgaaag     2700

taaaagatgc tgaagatcag ttgggtgcac gagtgggtta catcgaactg gatctcaaca     2760

gcggtaagat ccttgagagt tttcgccccg aagaacgttt tccaatgatg agcactttta     2820

aagttctgct atgtggcgcg gtattatccc gtattgacgc cgggcaagag caactcggtc     2880

gccgcataca ctattctcag aatgacttgg ttgagtactc accagtcaca gaaaagcatc     2940

ttacggatgg catgacagta agagaattat gcagtgctgc cataaccatg agtgataaca     3000

ctgcggccaa cttacttctg acaacgatcg gaggaccgaa ggagctaacc gcttttttgc     3060

acaacatggg ggatcatgta actcgccttg atcgttggga accggagctg aatgaagcca     3120

taccaaacga cgagcgtgac accacgatgc ctgtagcaat ggcaacaacg ttgcgcaaac     3180

tattaactgg cgaactactt actctagctt cccggcaaca attaatagac tggatggagg     3240

cggataaagt tgcaggacca cttctgcgct cggcccttcc ggctggctgg tttattgctg     3300

ataaatctgg agccggtgag cgtgggtctc gcggtatcat tgcagcactg gggccagatg     3360

gtaagccctc ccgtatcgta gttatctaca cgacggggag tcaggcaact atggatgaac     3420

gaaatagaca gatcgctgag ataggtgcct cactgattaa gcattggtaa ctgtcagacc     3480

aagtttactc atatatactt tagattgatt taaaacttca tttttaattt aaaaggatct     3540

aggtgaagat cctttttgat aatctcatga ccaaaatccc ttaacgtgag ttttcgttcc     3600

actgagcgtc agaccccgta gaaaagatca aaggatcttc ttgagatcct ttttttctgc     3660

gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt tgtttgccgg     3720

atcaagagct accaactctt tttccgaagg taactggctt cagcagagcg cagataccaa     3780

atactgttct tctagtgtag ccgtagttag gccaccactt caagaactct gtagcaccgc     3840

ctacatacct cgctctgcta atcctgttac cagtggctgc tgccagtggc gataagtcgt     3900

gtcttaccgg gttggactca agacgatagt taccggataa ggcgcagcgg tcgggctgaa     3960

cggggggttc gtgcacacag cccagcttgg agcgaacgac ctacaccgaa ctgagatacc     4020

tacagcgtga gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc     4080

cggtaagcgg cagggtcgga acaggagagc gcacgaggga gcttccaggg ggaaacgcct     4140

ggtatcttta tagtcctgtc gggtttcgcc acctctgact tgagcgtcga tttttgtgat     4200

gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa cgcggccttt ttacggttcc     4260

tggccttttg ctggcctttt gctcacatgt tctttcctgc gttatcccct gattctgtgg     4320

ataaccgtat taccgccttt gagtgagctg ataccgctcg ccgcagccga acgaccgagc     4380

gcagcgagtc agtgagcgag gaagcggaag agcgcccaat acgcaaaccg cctctccccg     4440

cgcgttggcc gattcattaa tgcagctggc acgacaggtt tcccgactgg aaagcgggca     4500

gtgagcgcaa cgcaattaat gtgagttagc tcactcatta ggcaccccag gctttacact     4560

ttatgcttcc ggctcgtatg ttgtgtggaa ttgtgagcgg ataacaattt cacacaggaa     4620

acagctatga ccatgattac gccaagctct cgagatctag aaagcttccc ggggggatct     4680

g                                                                     4681


<210>  21
<211>  1494
<212>  DNA
<213>  Homo sapiens

<400>  21
atgcccaccc ccgacgccac cacgccacag gccaagggct tccgcagggc cgtgtctgag       60

ctggacgcca agcaggcaga ggccatcatg tccccgcggt tcattgggcg caggcagagc      120

ctcatcgagg acgcccgcaa ggagcgggag gcggcggtgg cagcagcggc cgctgcagtc      180

ccctcggagc ccggggaccc cctggaggct gtggcctttg aggagaagga ggggaaggcc      240

gtgctaaacc tgctcttctc cccgagggcc accaagccct cggcgctgtc ccgagctgtg      300

aaggtgtttg agacgtttga agccaaaatc caccatctag agacccggcc cgcccagagg      360

ccgcgagctg ggggccccca cctggagtac ttcgtgcgcc tcgaggtgcg ccgaggggac      420

ctggccgccc tgctcagtgg tgtgcgccag gtgtcagagg acgtgcgcag ccccgcgggg      480

cccaaggtcc cctggttccc aagaaaagtg tcagagctgg acaagtgtca tcacctggtc      540

accaagttcg accctgacct ggacttggac cacccgggct tctcggacca ggtgtaccgc      600

cagcgcagga agctgattgc tgagatcgcc ttccagtaca ggcacggcga cccgattccc      660

cgtgtggagt acaccgccga ggagattgcc acctggaagg aggtctacac cacgctgaag      720

ggcctctacg ccacgcacgc ctgcggggag cacctggagg cctttgcttt gctggagcgc      780

ttcagcggct accgggaaga caatatcccc cagctggagg acgtctcccg cttcctgaag      840

gagcgcacgg gcttccagct gcggcctgtg gccggcctgc tgtccgcccg ggacttcctg      900

gccagcctgg ccttccgcgt gttccagtgc acccagtata tccgccacgc gtcctcgccc      960

atgcactccc ctgagccgga ctgctgccac gagctgctgg ggcacgtgcc catgctggcc     1020

gaccgcacct tcgcgcagtt ctcgcaggac attggcctgg cgtccctggg ggcctcggat     1080

gaggaaattg agaagctgtc cacgctgtca tggttcacgg tggagttcgg gctgtgtaag     1140

cagaacgggg aggtgaaggc ctatggtgcc gggctgctgt cctcctacgg ggagctcctg     1200

cactgcctgt ctgaggagcc tgagattcgg gccttcgacc ctgaggctgc ggccgtgcag     1260

ccctaccaag accagacgta ccagtcagtc tacttcgtgt ctgagagctt cagtgacgcc     1320

aaggacaagc tcaggagcta tgcctcacgc atccagcgcc ccttctccgt gaagttcgac     1380

ccgtacacgc tggccatcga cgtgctggac agcccccagg ccgtgcggcg ctccctggag     1440

ggtgtccagg atgagctgga cacccttgcc catgcgctga gtgccattgg ctag           1494


<210>  22
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Pro Thr Pro Asp Ala Thr Thr Pro Gln Ala Lys Gly Phe Arg Arg 
1               5                   10                  15      


Ala Val Ser Glu Leu Asp Ala Lys Gln Ala Glu Ala Ile Met Ser Pro 
            20                  25                  30          


Arg Phe Ile Gly Arg Arg Gln Ser Leu Ile Glu Asp Ala Arg Lys Glu 
        35                  40                  45              


Arg Glu Ala Ala Val Ala Ala Ala Ala Ala Ala Val Pro Ser Glu Pro 
    50                  55                  60                  


Gly Asp Pro Leu Glu Ala Val Ala Phe Glu Glu Lys Glu Gly Lys Ala 
65                  70                  75                  80  


Val Leu Asn Leu Leu Phe Ser Pro Arg Ala Thr Lys Pro Ser Ala Leu 
                85                  90                  95      


Ser Arg Ala Val Lys Val Phe Glu Thr Phe Glu Ala Lys Ile His His 
            100                 105                 110         


Leu Glu Thr Arg Pro Ala Gln Arg Pro Arg Ala Gly Gly Pro His Leu 
        115                 120                 125             


Glu Tyr Phe Val Arg Leu Glu Val Arg Arg Gly Asp Leu Ala Ala Leu 
    130                 135                 140                 


Leu Ser Gly Val Arg Gln Val Ser Glu Asp Val Arg Ser Pro Ala Gly 
145                 150                 155                 160 


Pro Lys Val Pro Trp Phe Pro Arg Lys Val Ser Glu Leu Asp Lys Cys 
                165                 170                 175     


His His Leu Val Thr Lys Phe Asp Pro Asp Leu Asp Leu Asp His Pro 
            180                 185                 190         


Gly Phe Ser Asp Gln Val Tyr Arg Gln Arg Arg Lys Leu Ile Ala Glu 
        195                 200                 205             


Ile Ala Phe Gln Tyr Arg His Gly Asp Pro Ile Pro Arg Val Glu Tyr 
    210                 215                 220                 


Thr Ala Glu Glu Ile Ala Thr Trp Lys Glu Val Tyr Thr Thr Leu Lys 
225                 230                 235                 240 


Gly Leu Tyr Ala Thr His Ala Cys Gly Glu His Leu Glu Ala Phe Ala 
                245                 250                 255     


Leu Leu Glu Arg Phe Ser Gly Tyr Arg Glu Asp Asn Ile Pro Gln Leu 
            260                 265                 270         


Glu Asp Val Ser Arg Phe Leu Lys Glu Arg Thr Gly Phe Gln Leu Arg 
        275                 280                 285             


Pro Val Ala Gly Leu Leu Ser Ala Arg Asp Phe Leu Ala Ser Leu Ala 
    290                 295                 300                 


Phe Arg Val Phe Gln Cys Thr Gln Tyr Ile Arg His Ala Ser Ser Pro 
305                 310                 315                 320 


Met His Ser Pro Glu Pro Asp Cys Cys His Glu Leu Leu Gly His Val 
                325                 330                 335     


Pro Met Leu Ala Asp Arg Thr Phe Ala Gln Phe Ser Gln Asp Ile Gly 
            340                 345                 350         


Leu Ala Ser Leu Gly Ala Ser Asp Glu Glu Ile Glu Lys Leu Ser Thr 
        355                 360                 365             


Leu Ser Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Gln Asn Gly Glu 
    370                 375                 380                 


Val Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser Tyr Gly Glu Leu Leu 
385                 390                 395                 400 


His Cys Leu Ser Glu Glu Pro Glu Ile Arg Ala Phe Asp Pro Glu Ala 
                405                 410                 415     


Ala Ala Val Gln Pro Tyr Gln Asp Gln Thr Tyr Gln Ser Val Tyr Phe 
            420                 425                 430         


Val Ser Glu Ser Phe Ser Asp Ala Lys Asp Lys Leu Arg Ser Tyr Ala 
        435                 440                 445             


Ser Arg Ile Gln Arg Pro Phe Ser Val Lys Phe Asp Pro Tyr Thr Leu 
    450                 455                 460                 


Ala Ile Asp Val Leu Asp Ser Pro Gln Ala Val Arg Arg Ser Leu Glu 
465                 470                 475                 480 


Gly Val Gln Asp Glu Leu Asp Thr Leu Ala His Ala Leu Ser Ala Ile 
                485                 490                 495     


Gly 
    


<210>  23
<211>  1029
<212>  DNA
<213>  Homo sapiens

<400>  23
atgagccccg cggggcccaa ggtcccctgg ttcccaagaa aagtgtcaga gctggacaag       60

tgtcatcacc tggtcaccaa gttcgaccct gacctggact tggaccaccc gggcttctcg      120

gaccaggtgt accgccagcg caggaagctg attgctgaga tcgccttcca gtacaggcac      180

ggcgacccga ttccccgtgt ggagtacacc gccgaggaga ttgccacctg gaaggaggtc      240

tacaccacgc tgaagggcct ctacgccacg cacgcctgcg gggagcacct ggaggccttt      300

gctttgctgg agcgcttcag cggctaccgg gaagacaata tcccccagct ggaggacgtc      360

tcccgcttcc tgaaggagcg cacgggcttc cagctgcggc ctgtggccgg cctgctgtcc      420

gcccgggact tcctggccag cctggccttc cgcgtgttcc agtgcaccca gtatatccgc      480

cacgcgtcct cgcccatgca ctcccctgag ccggactgct gccacgagct gctggggcac      540

gtgcccatgc tggccgaccg caccttcgcg cagttctcgc aggacattgg cctggcgtcc      600

ctgggggcct cggatgagga aattgagaag ctgtccacgc tgtactggtt cacggtggag      660

ttcgggctgt gtaagcagaa cggggaggtg aaggcctatg gtgccgggct gctgtcctcc      720

tacggggagc tcctgcactg cctgtctgag gagcctgaga ttcgggcctt cgaccctgag      780

gctgcggccg tgcagcccta ccaagaccag acgtaccagt cagtctactt cgtgtctgag      840

agcttcagtg acgccaagga caagctcagg agctatgcct cacgcatcca gcgccccttc      900

tccgtgaagt tcgacccgta cacgctggcc atcgacgtgc tggacagccc ccaggccgtg      960

cggcgctccc tggagggtgt ccaggatgag ctggacaccc ttgcccatgc gctgagtgcc     1020

attggctag                                                             1029


<210>  24
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ser Pro Ala Gly Pro Lys Val Pro Trp Phe Pro Arg Lys Val Ser 
1               5                   10                  15      


Glu Leu Asp Lys Cys His His Leu Val Thr Lys Phe Asp Pro Asp Leu 
            20                  25                  30          


Asp Leu Asp His Pro Gly Phe Ser Asp Gln Val Tyr Arg Gln Arg Arg 
        35                  40                  45              


Lys Leu Ile Ala Glu Ile Ala Phe Gln Tyr Arg His Gly Asp Pro Ile 
    50                  55                  60                  


Pro Arg Val Glu Tyr Thr Ala Glu Glu Ile Ala Thr Trp Lys Glu Val 
65                  70                  75                  80  


Tyr Thr Thr Leu Lys Gly Leu Tyr Ala Thr His Ala Cys Gly Glu His 
                85                  90                  95      


Leu Glu Ala Phe Ala Leu Leu Glu Arg Phe Ser Gly Tyr Arg Glu Asp 
            100                 105                 110         


Asn Ile Pro Gln Leu Glu Asp Val Ser Arg Phe Leu Lys Glu Arg Thr 
        115                 120                 125             


Gly Phe Gln Leu Arg Pro Val Ala Gly Leu Leu Ser Ala Arg Asp Phe 
    130                 135                 140                 


Leu Ala Ser Leu Ala Phe Arg Val Phe Gln Cys Thr Gln Tyr Ile Arg 
145                 150                 155                 160 


His Ala Ser Ser Pro Met His Ser Pro Glu Pro Asp Cys Cys His Glu 
                165                 170                 175     


Leu Leu Gly His Val Pro Met Leu Ala Asp Arg Thr Phe Ala Gln Phe 
            180                 185                 190         


Ser Gln Asp Ile Gly Leu Ala Ser Leu Gly Ala Ser Asp Glu Glu Ile 
        195                 200                 205             


Glu Lys Leu Ser Thr Leu Ser Trp Phe Thr Val Glu Phe Gly Leu Cys 
    210                 215                 220                 


Lys Gln Asn Gly Glu Val Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser 
225                 230                 235                 240 


Tyr Gly Glu Leu Leu His Cys Leu Ser Glu Glu Pro Glu Ile Arg Ala 
                245                 250                 255     


Phe Asp Pro Glu Ala Ala Ala Val Gln Pro Tyr Gln Asp Gln Thr Tyr 
            260                 265                 270         


Gln Ser Val Tyr Phe Val Ser Glu Ser Phe Ser Asp Ala Lys Asp Lys 
        275                 280                 285             


Leu Arg Ser Tyr Ala Ser Arg Ile Gln Arg Pro Phe Ser Val Lys Phe 
    290                 295                 300                 


Asp Pro Tyr Thr Leu Ala Ile Asp Val Leu Asp Ser Pro Gln Ala Val 
305                 310                 315                 320 


Arg Arg Ser Leu Glu Gly Val Gln Asp Glu Leu Asp Thr Leu Ala His 
                325                 330                 335     


Ala Leu Ser Ala Ile Gly 
            340         


<210>  25
<211>  589
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV promoter

<400>  25
tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg       60

cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt      120

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      180

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      240

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      300

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      360

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      420

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      480

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      540

acggtgggag gtctatataa gcagagctgg tttagtgaac cgtcagatc                  589


<210>  26
<211>  272
<212>  DNA
<213>  Homo sapiens

<400>  26
ttcgaacagg taagcgcccc taaaatccct ttgggcacaa tgtgtcctga ggggagaggc       60

agcgacctgt agatgggacg ggggcactaa ccctcaggtt tggggcttct gaatgtgagt      120

atcgccatgt aagcccagta tttggccaat ctcagaaagc tcctggtccc tggagggatg      180

gagagagaaa aacaaacagc tcctggagca gggagagtgc tggcctcttg ctctccggct      240

ccctctgttg ccctctggtt tctccccagg tt                                    272


<210>  27
<211>  82
<212>  DNA
<213>  Mice minute virus

<400>  27
gtaagggttt aagggatggt tggttggtgg ggtattaatg tttaattacc tggagcacct       60

gcctgaaatc actttttttc ag                                                82


<210>  28
<211>  304
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3'UTR coding sequence

<400>  28
gtgcacggcg tccctgaggg cccttcccaa cctcccctgg tcctgcactg tcccggagct       60

caggccctgg tgaggggctg ggtcccgggt gccccccatg ccctccctgc tgccaggctc      120

ccactgcccc tgcacctgct tctcagcgca acagctgtgt gtgcccgtgg tgaggttgtg      180

ctgcctgtgg tgaggtcctg tcctggctcc cagggtcctg ggggctgctg cactgccctc      240

cgcccttccc tgacactgtc tgctgcccca atcaccgtca caataaaaga aactgtggtc      300

tcta                                                                   304


<210>  29
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5'UTR coding sequence

<400>  29
gccacc                                                                   6


