                         SEQUENCE LISTING

<110>  Helmholtz Zentrum Muenchen - Deutsches Forschungszentrum 
       fuer Gesundheit und Umwelt GmbH
       Reinhard Zeidler
 
<120>  Compostion comprising an antibody which binds to human PRDX4 
       present on the cell surface of a target cell

<130>  HEL17270PCT

<150>  LU 102276
<151>  2020-12-10

<150>  EP 21155773.1
<151>  2021-02-08

<160>  82    

<170>  PatentIn version 3.5

<210>  1
<211>  117
<212>  PRT
<213>  artificial

<220>
<223>  2C1 VH region

<400>  1

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Asn 
            20                  25                  30          


His Met Asn Trp Ile Lys Gln Thr Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Asn Ser Gly Asn Gly Gly Thr Lys Tyr Asn Val Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Phe 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Pro Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Pro Ala Ser Phe Asp Tyr Trp Gly Gln Gly Val Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  2
<211>  110
<212>  PRT
<213>  artificial

<220>
<223>  2C1 VL region

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Lys Ala Ser Gln Asn Ile Asn Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln His Lys Leu Gly Glu Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asp Asn Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Leu Gln His Ser Asn Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Ala Arg Ala Asp 
            100                 105                 110 


<210>  3
<211>  117
<212>  PRT
<213>  artificial

<220>
<223>  5H5 VH region

<400>  3

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Asn 
            20                  25                  30          


His Met His Trp Ile Lys Glu Thr Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Asn Pro Gly Asn Gly Gly Ser Arg Phe Asn Val Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Thr Thr Ala Phe 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Pro Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Pro Ala Ser Phe Asp Tyr Trp Gly Gln Gly Val Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  4
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  5H5 VL region

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Arg Ala Ser Glu Asn Ile Tyr Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Phe Gly Glu Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asn Thr Leu Glu Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Leu Gln His Ser Asn Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ala 
            100                 105                 


<210>  5
<211>  117
<212>  PRT
<213>  artificial

<220>
<223>  10G7 VH region

<400>  5

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Asn 
            20                  25                  30          


His Met Asn Trp Ile Lys Gln Thr Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Asn Pro Val Asn Gly Gly Thr Arg Tyr Asn Val Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Phe 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Pro Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Pro Ala Ser Phe Asp Tyr Trp Gly Gln Gly Val Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  6
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  10G7 VL region

<400>  6

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Lys Ala Ser Gln Asn Ile His Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln His Lys Leu Gly Glu Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asn Asn Leu Gln Thr Asp Ile Pro Ser Asn Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Leu Gln His Ser Ser Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ala 
            100                 105                 


<210>  7
<211>  117
<212>  PRT
<213>  artificial

<220>
<223>  11-F2 VH region

<400>  7

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Thr His 
            20                  25                  30          


His Met His Trp Ile Lys Glu Thr Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Asn Pro Gly Asn Gly Gly Thr Lys Tyr Asn Val Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Ser Ser Ser Ser Thr Ala Phe 
65                  70                  75                  80  


Met Gln Leu Gly Ser Leu Thr Pro Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Pro Ala Ser Phe Asp Tyr Trp Gly Gln Gly Val Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  8
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  11-F2 VL region

<400>  8

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Lys Ala Ser Gln Asn Ile Tyr Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asn Asn Leu Glu Thr Asp Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Leu Gln His Ser Asn Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ala 
            100                 105                 


<210>  9
<211>  117
<212>  PRT
<213>  artificial

<220>
<223>  13B2 VH region

<400>  9

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Asn 
            20                  25                  30          


His Met Asn Trp Ile Lys Glu Thr Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Asn Pro Gly Asn Gly Gly Ser Arg Phe Asn Val Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Thr Thr Ala Phe 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Pro Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Pro Ala Ser Phe Asp Tyr Trp Gly Gln Gly Val Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  10
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  13B2 VL region

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Arg Ala Ser Glu Asn Ile Tyr Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asn Thr Leu Glu Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Leu Gln His Ser Asn Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ala 
            100                 105                 


<210>  11
<211>  117
<212>  PRT
<213>  artificial

<220>
<223>  15-F11 VH region

<400>  11

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Asn 
            20                  25                  30          


His Met His Trp Ile Lys Glu Thr Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Asn Pro Gly Asn Gly Gly Ser Arg Phe Asn Val Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Thr Thr Ala Phe 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Pro Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Pro Ala Ser Phe Asp Tyr Trp Gly Gln Gly Val Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  12
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  15-F11 VL region

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Phe Asn Cys Arg Ala Ser Glu Asn Ile Tyr Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Arg Lys Phe Gly Glu Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Ser Asn Thr Asn Thr Leu Glu Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Leu Gln His Ser Asn Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ala 
            100                 105                 


<210>  13
<211>  117
<212>  PRT
<213>  artificial

<220>
<223>  17A10 VH region

<400>  13

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Asn 
            20                  25                  30          


His Met His Trp Ile Lys Glu Thr Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Asn Pro Gly Asn Gly Gly Ser Arg Phe Asn Val Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Tyr Thr Thr Ala Phe 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Pro Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Pro Ala Ser Phe Asp Tyr Trp Gly Arg Gly Val Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  14
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  17A10 VL region

<400>  14

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Arg Ala Ser Glu Asn Ile Tyr Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Phe Gly Glu Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asn Thr Leu Glu Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Leu Gln His Ser Asn Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ala 
            100                 105                 


<210>  15
<211>  117
<212>  PRT
<213>  artificial

<220>
<223>  18G8 VH region

<400>  15

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Glu Pro Gly Thr 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Asn 
            20                  25                  30          


His Ile His Trp Ile Lys Gln Ala Thr Gly Gln Ala Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Asn Ser Gly Asn Gly Gly Thr Lys Tyr Asp Val Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Phe 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Pro Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Pro Ala Ser Phe Asp Tyr Trp Gly Gln Gly Val Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  16
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  18G8 VL region

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Leu Thr Ile Asn Cys Lys Ala Ser Gln Asn Ile Tyr Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Asp Thr Asn Asn Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Leu Gln His Ser Asn Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ala 
            100                 105                 


<210>  17
<211>  117
<212>  PRT
<213>  artificial

<220>
<223>  19H9 VH region

<400>  17

Gln Val Gln Leu Gln Gln Ser Gly Val Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Asn 
            20                  25                  30          


His Met His Trp Ile Lys Glu Thr Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Asn Pro Gly Asn Gly Gly Ser Arg Phe Asn Val Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Thr Thr Ala Phe 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Pro Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Pro Ala Ser Phe Asp Tyr Trp Gly Gln Gly Val Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  18
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  19H9 VL region

<400>  18

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Arg Ala Ser Glu Asn Ile Tyr Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Phe Gly Glu Gly Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asn Thr Leu Glu Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Leu Gln His Ser Asn Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ala 
            100                 105                 


<210>  19
<211>  117
<212>  PRT
<213>  artificial

<220>
<223>  24B7 VH region

<400>  19

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Asn 
            20                  25                  30          


His Met His Trp Ile Lys Glu Thr Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Asn Pro Gly Asn Gly Gly Ser Arg Phe Asn Val Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Thr Thr Ala Phe 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Pro Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Pro Ala Ser Phe Asp Tyr Trp Gly Arg Gly Val Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  20
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  24B7 VH region

<400>  20

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Arg Ala Ser Glu Asn Ile Tyr Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Phe Gly Glu Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asn Thr Leu Glu Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Leu Gln His Ser Asn Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ala 
            100                 105                 


<210>  21
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  2C1 VH-CDR1

<400>  21

Thr Ser Asn His Met Asn 
1               5       


<210>  22
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  2C1 VH-CDR2

<400>  22

Ile Ile Asn Ser Gly Asn Gly Gly Thr Lys Tyr Asn Val Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  23
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  2C1 VH-CDR3

<400>  23

Gly Asn Pro Ala Ser Phe Asp Tyr 
1               5               


<210>  24
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  2C1 VL-CDR1

<400>  24

Lys Ala Ser Gln Asn Ile Asn Lys Tyr Leu Asn 
1               5                   10      


<210>  25
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  2C1 VL-CDR2

<400>  25

Asn Thr Asp Asn Leu Gln Thr 
1               5           


<210>  26
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  2C1 VL-CDR3

<400>  26

Leu Gln His Ser Asn Phe Pro Phe Thr 
1               5                   


<210>  27
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  5H5 VH-CDR1

<400>  27

Thr Ser Asn His Met His 
1               5       


<210>  28
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  5H5 VH-CDR2

<400>  28

Ile Ile Asn Pro Gly Asn Gly Gly Ser Arg Phe Asn Val Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  29
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  5H5 VH-CDR3

<400>  29

Gly Asn Pro Ala Ser Phe Asp Tyr 
1               5               


<210>  30
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  5H5 VL-CDR1

<400>  30

Arg Ala Ser Glu Asn Ile Tyr Lys Tyr Leu Asn 
1               5                   10      


<210>  31
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  5H5 VL-CDR2

<400>  31

Asn Thr Asn Thr Leu Glu Thr Gly 
1               5               


<210>  32
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  5H5 VL-CDR3

<400>  32

Leu Gln His Ser Asn Phe Pro Phe Thr 
1               5                   


<210>  33
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  10G7 VH-CDR1

<400>  33

Thr Ser Asn His Met Asn 
1               5       


<210>  34
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  10G7 VH-CDR2

<400>  34

Ile Ile Asn Pro Val Asn Gly Gly Thr Arg Tyr Asn Val Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  35
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  10G7 VH-CDR3

<400>  35

Gly Asn Pro Ala Ser Phe Asp Tyr 
1               5               


<210>  36
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  10G7 VL-CDR1

<400>  36

Lys Ala Ser Gln Asn Ile His Lys Tyr Leu Asn 
1               5                   10      


<210>  37
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  10G7 VL-CDR2

<400>  37

Asn Thr Asn Asn Leu Gln Thr 
1               5           


<210>  38
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  10G7 VL-CDR3

<400>  38

Leu Gln His Ser Ser Phe Pro Phe Thr 
1               5                   


<210>  39
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  11F2 VH-CDR1

<400>  39

Ser Thr His His Met His 
1               5       


<210>  40
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  11F2 VH-CDR2

<400>  40

Ile Ile Asn Pro Gly Asn Gly Gly Thr Lys Tyr Asn Val Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  41
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  11F2 VH-CDR3

<400>  41

Gly Asn Pro Ala Ser Phe Asp Tyr 
1               5               


<210>  42
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  11F2 VL-CDR1

<400>  42

Lys Ala Ser Gln Asn Ile Tyr Lys Tyr Leu Asn 
1               5                   10      


<210>  43
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  11F2 VL-CDR2

<400>  43

Tyr Asn Thr Asn Asn Leu Glu Thr Asp 
1               5                   


<210>  44
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  11F2 VL-CDR3

<400>  44

Leu Gln His Ser Asn Phe Pro Phe Thr 
1               5                   


<210>  45
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  13B2 VH-CDR1

<400>  45

Thr Ser Asn His Met Asn 
1               5       


<210>  46
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  13B2 VH-CDR2

<400>  46

Ile Ile Asn Pro Gly Asn Gly Gly Ser Arg Phe Asn Val Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  47
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  13B2 VH-CDR3

<400>  47

Gly Asn Pro Ala Ser Phe Asp Tyr 
1               5               


<210>  48
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  13B2 VL-CDR1

<400>  48

Arg Ala Ser Glu Asn Ile Tyr Lys Tyr Leu Asn 
1               5                   10      


<210>  49
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  13B2 VL-CDR2

<400>  49

Tyr Asn Thr Asn Thr Leu Glu Thr Gly 
1               5                   


<210>  50
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  13B2 VL-CDR3

<400>  50

Leu Gln His Ser Asn Phe Pro Phe Thr 
1               5                   


<210>  51
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  15F11 VH-CDR1

<400>  51

Thr Ser Asn His Met His 
1               5       


<210>  52
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  15F11 VH-CDR2

<400>  52

Ile Ile Asn Pro Gly Asn Gly Gly Ser Arg Phe Asn Val Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  53
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  15F11 VH-CDR3

<400>  53

Gly Asn Pro Ala Ser Phe Asp Tyr 
1               5               


<210>  54
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  15F11 VL-CDR1

<400>  54

Arg Ala Ser Glu Asn Ile Tyr Asn Tyr Leu Asn 
1               5                   10      


<210>  55
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  15F11 VL-CDR2

<400>  55

Ser Asn Thr Asn Thr Leu Glu Thr Gly 
1               5                   


<210>  56
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  15F11 VL-CDR3

<400>  56

Leu Gln His Ser Asn Phe Pro Phe Thr 
1               5                   


<210>  57
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  17A10 VH-CDR1

<400>  57

Thr Ser Asn His Met His 
1               5       


<210>  58
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  17A10 VH-CDR2

<400>  58

Ile Ile Asn Pro Gly Asn Gly Gly Ser Arg Phe Asn Val Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  59
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  17A10 VH-CDR3

<400>  59

Gly Asn Pro Ala Ser Phe Asp Tyr 
1               5               


<210>  60
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  17A10 VL-CDR1

<400>  60

Arg Ala Ser Glu Asn Ile Tyr Asn Tyr Leu Asn 
1               5                   10      


<210>  61
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  17A10 VL-CDR2

<400>  61

Tyr Asn Thr Asn Thr Leu Glu Thr Gly 
1               5                   


<210>  62
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  17A10 VL-CDR3

<400>  62

Leu Gln His Ser Asn Phe Pro Phe Thr 
1               5                   


<210>  63
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  18G8 VH-CDR1

<400>  63

Thr Asn Asn His Ile His 
1               5       


<210>  64
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  18G8 VH-CDR2

<400>  64

Ile Ile Asn Ser Gly Asn Gly Gly Thr Lys Tyr Asp Val Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  65
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  18G8 VH-CDR3

<400>  65

Gly Asn Pro Ala Ser Phe Asp Tyr 
1               5               


<210>  66
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  18G8 VL-CDR1

<400>  66

Lys Ala Ser Gln Asn Ile Tyr Lys Tyr Leu Asn 
1               5                   10      


<210>  67
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  18G8 VL-CDR2

<400>  67

Asp Thr Asn Asn Leu Gln Thr Gly 
1               5               


<210>  68
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  18G8 VL-CDR3

<400>  68

Leu Gln His Ser Asn Phe Pro Phe Thr 
1               5                   


<210>  69
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  19H9 VH-CDR1

<400>  69

Thr Ser Asn His Met His 
1               5       


<210>  70
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  19H9 VH-CDR2

<400>  70

Ile Ile Asn Pro Gly Asn Gly Gly Ser Arg Phe Asn Val Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  71
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  19H9 VH-CDR3

<400>  71

Gly Asn Pro Ala Ser Phe Asp Tyr 
1               5               


<210>  72
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  19H9 VL-CDR1

<400>  72

Arg Ala Ser Glu Asn Ile Tyr Asn Tyr Leu Asn 
1               5                   10      


<210>  73
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  19H9 VL-CDR2

<400>  73

Asn Thr Asn Thr Leu Glu Thr Gly 
1               5               


<210>  74
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  19H9 VL-CDR3

<400>  74

Leu Gln His Ser Asn Phe Pro Phe Thr 
1               5                   


<210>  75
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  24B7 VH-CDR1

<400>  75

Thr Ser Asn His Met His 
1               5       


<210>  76
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  24B7 VH-CDR2

<400>  76

Ile Ile Asn Pro Gly Asn Gly Gly Ser Arg Phe Asn Val Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  77
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  24B7 VH-CDR3

<400>  77

Gly Asn Pro Ala Ser Phe Asp Tyr 
1               5               


<210>  78
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  24B7 VL-CDR1

<400>  78

Arg Ala Ser Glu Asn Ile Tyr Asn Tyr Leu Asn 
1               5                   10      


<210>  79
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  24B7 VL-CDR2

<400>  79

Asn Thr Asn Thr Leu Glu Thr Gly 
1               5               


<210>  80
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  24B7 VL-CDR3

<400>  80

Leu Gln His Ser Asn Phe Pro Phe Thr 
1               5                   


<210>  81
<211>  271
<212>  PRT
<213>  human

<400>  81

Met Glu Ala Leu Pro Leu Leu Ala Ala Thr Thr Pro Asp His Gly Arg 
1               5                   10                  15      


His Arg Arg Leu Leu Leu Leu Pro Leu Leu Leu Phe Leu Leu Pro Ala 
            20                  25                  30          


Gly Ala Val Gln Gly Trp Glu Thr Glu Glu Arg Pro Arg Thr Arg Glu 
        35                  40                  45              


Glu Glu Cys His Phe Tyr Ala Gly Gly Gln Val Tyr Pro Gly Glu Ala 
    50                  55                  60                  


Ser Arg Val Ser Val Ala Asp His Ser Leu His Leu Ser Lys Ala Lys 
65                  70                  75                  80  


Ile Ser Lys Pro Ala Pro Tyr Trp Glu Gly Thr Ala Val Ile Asp Gly 
                85                  90                  95      


Glu Phe Lys Glu Leu Lys Leu Thr Asp Tyr Arg Gly Lys Tyr Leu Val 
            100                 105                 110         


Phe Phe Phe Tyr Pro Leu Asp Phe Thr Phe Val Cys Pro Thr Glu Ile 
        115                 120                 125             


Ile Ala Phe Gly Asp Arg Leu Glu Glu Phe Arg Ser Ile Asn Thr Glu 
    130                 135                 140                 


Val Val Ala Cys Ser Val Asp Ser Gln Phe Thr His Leu Ala Trp Ile 
145                 150                 155                 160 


Asn Thr Pro Arg Arg Gln Gly Gly Leu Gly Pro Ile Arg Ile Pro Leu 
                165                 170                 175     


Leu Ser Asp Leu Thr His Gln Ile Ser Lys Asp Tyr Gly Val Tyr Leu 
            180                 185                 190         


Glu Asp Ser Gly His Thr Leu Arg Gly Leu Phe Ile Ile Asp Asp Lys 
        195                 200                 205             


Gly Ile Leu Arg Gln Ile Thr Leu Asn Asp Leu Pro Val Gly Arg Ser 
    210                 215                 220                 


Val Asp Glu Thr Leu Arg Leu Val Gln Ala Phe Gln Tyr Thr Asp Lys 
225                 230                 235                 240 


His Gly Glu Val Cys Pro Ala Gly Trp Lys Pro Gly Ser Glu Thr Ile 
                245                 250                 255     


Ile Pro Asp Pro Ala Gly Lys Leu Lys Tyr Phe Asp Lys Leu Asn 
            260                 265                 270     


<210>  82
<211>  9
<212>  PRT
<213>  human

<400>  82

Trp Glu Thr Glu Glu Arg Pro Arg Thr 
1               5                   


