                         SEQUENCE LISTING

<110>  Sotio Biotech a.s.
 
<120>  Humanized CLDN18.2 antibodies

<130>  S12415WO / SOTCLD-1903WO

<160>  159   

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 Consensus Sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  T or S

<400>  1

Gly Tyr Xaa Phe Thr Ser Tyr Trp Ile Gly 
1               5                   10  


<210>  2
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Consensus Sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  N or I

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  S or G

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  A, E or D

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  A or S

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Y or D

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  N or R

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  A or S

<400>  2

Gly Xaa Ile Tyr Pro Xaa Xaa Xaa Xaa Thr Xaa Tyr Xaa 
1               5                   10              


<210>  3
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 Consensus Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  A or T

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  L, M, I or Q

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  A or Y

<400>  3

Xaa Arg Xaa Trp Arg Gly Asn Ser Phe Asp Xaa 
1               5                   10      


<210>  4
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1 Consensus Sequence


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  L or V

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  T or A

<400>  4

Lys Ser Ser Gln Ser Xaa Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Xaa 
    


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2 Consensus Sequence

<400>  5

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3 Consensus Sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  N or Q

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  L or F

<400>  6

Gln Xaa Asp Tyr Ser Tyr Pro Xaa Thr 
1               5                   


<210>  7
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-1, hGBA-2, hGBA-3, hGBA-4, hGBA-5, hGBA-7, hGBA-8 HCDR1 
       Sequence

<400>  7

Gly Tyr Ser Phe Thr Ser Tyr Trp Ile Gly 
1               5                   10  


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-6, hGBA-9 HCDR1 Sequence

<400>  8

Gly Tyr Thr Phe Thr Ser Tyr Trp Ile Gly 
1               5                   10  


<210>  9
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-1 HCDR2 Sequence

<400>  9

Gly Asn Ile Tyr Pro Gly Ala Ser Asp Thr Arg Tyr Ala 
1               5                   10              


<210>  10
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-2 HCDR2 Sequence

<400>  10

Gly Asn Ile Tyr Pro Gly Asp Ala Asp Thr Arg Tyr Ala 
1               5                   10              


<210>  11
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-3 HCDR2 Sequence

<400>  11

Gly Ile Ile Tyr Pro Gly Ala Ser Asp Thr Asn Tyr Ala 
1               5                   10              


<210>  12
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-4 HCDR2 Sequence

<400>  12

Gly Ile Ile Tyr Pro Gly Asp Ala Tyr Thr Arg Tyr Ser 
1               5                   10              


<210>  13
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-5 HCDR2 Sequence

<400>  13

Gly Ile Ile Tyr Pro Gly Ala Ala Tyr Thr Arg Tyr Ala 
1               5                   10              


<210>  14
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-6 HCDR2 Sequence

<400>  14

Gly Asn Ile Tyr Pro Gly Ala Ser Tyr Thr Arg Tyr Ser 
1               5                   10              


<210>  15
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-7 HCDR2 Sequence

<400>  15

Gly Asn Ile Tyr Pro Gly Glu Ala Tyr Thr Arg Tyr Ser 
1               5                   10              


<210>  16
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-8 HCDR1 Sequence

<400>  16

Gly Asn Ile Tyr Pro Ser Glu Ser Tyr Thr Asn Tyr Ala 
1               5                   10              


<210>  17
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-9 HCDR2 Sequence

<400>  17

Gly Ile Ile Tyr Pro Ser Ala Ala Tyr Thr Arg Tyr Ala 
1               5                   10              


<210>  18
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-1, hGBA-5 HCDR3 Sequence

<400>  18

Ala Arg Leu Trp Arg Gly Asn Ser Phe Asp Tyr 
1               5                   10      


<210>  19
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-2 HCDR3 Sequence

<400>  19

Ala Arg Met Trp Arg Gly Asn Ser Phe Asp Tyr 
1               5                   10      


<210>  20
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-3 HCDR3 Sequence

<400>  20

Ala Arg Ile Trp Arg Gly Asn Ser Phe Asp Tyr 
1               5                   10      


<210>  21
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-4 HCDR3 Sequence

<400>  21

Thr Arg Leu Trp Arg Gly Asn Ser Phe Asp Ala 
1               5                   10      


<210>  22
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-6 HCDR3 Sequence

<400>  22

Thr Arg Gln Trp Arg Gly Asn Ser Phe Asp Tyr 
1               5                   10      


<210>  23
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-7, hGBA-8 HCDR3 Sequence

<400>  23

Thr Arg Leu Trp Arg Gly Asn Ser Phe Asp Tyr 
1               5                   10      


<210>  24
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-9 HCDR3 Sequence

<400>  24

Thr Arg Met Trp Arg Gly Asn Ser Phe Asp Tyr 
1               5                   10      


<210>  25
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-1, hGBA-3, hGBA-5, hGBA-6, hGBA-8 LCDR1 Sequence

<400>  25

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  26
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-4 LCDR1 Sequence

<400>  26

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  27
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-7 LCDR1 Sequence

<400>  27

Lys Ser Ser Gln Ser Val Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  28
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-9 LCDR1 Sequence

<400>  28

Lys Ser Ser Gln Ser Val Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-1, hGBA-3, hGBA-6, hGBA-7, hGBA-8 LCDR3 Sequence

<400>  29

Gln Asn Asp Tyr Ser Tyr Pro Phe Thr 
1               5                   


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-4 LCDR3 Sequence

<400>  30

Gln Asn Asp Tyr Ser Tyr Pro Leu Thr 
1               5                   


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-5, hGBA-9 LCDR3 Sequence

<400>  31

Gln Gln Asp Tyr Ser Tyr Pro Phe Thr 
1               5                   


<210>  32
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-1 VH Sequence

<400>  32

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Tyr Pro Gly Ala Ser Asp Thr Arg Tyr Ala Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Trp Arg Gly Asn Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  33
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-1, hGBA-2, hGBA-6 , hGBA-8  VL Sequence

<400>  33

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  34
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-2 VH Sequence

<400>  34

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Tyr Pro Gly Asp Ala Asp Thr Arg Tyr Ala Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Met Trp Arg Gly Asn Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  35
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-3 VH Sequence

<400>  35

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Ala Ser Asp Thr Asn Tyr Ala Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Trp Arg Gly Asn Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  36
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-3 VL Sequence

<400>  36

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  37
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-4 VH Sequence

<400>  37

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ala Tyr Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Leu Trp Arg Gly Asn Ser Phe Asp Ala Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  38
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-4 VL Sequence

<400>  38

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  39
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-5 VH Sequence

<400>  39

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Ala Ala Tyr Thr Arg Tyr Ala Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Trp Arg Gly Asn Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  40
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-5 VL Sequence

<400>  40

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  41
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-6 VH Sequence

<400>  41

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Tyr Pro Gly Ala Ser Tyr Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gln Trp Arg Gly Asn Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  42
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-7 VH Sequence

<400>  42

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Tyr Pro Gly Glu Ala Tyr Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Leu Trp Arg Gly Asn Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  43
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-7 VL Sequence

<400>  43

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  44
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-8 VH Sequence

<400>  44

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Tyr Pro Ser Glu Ser Tyr Thr Asn Tyr Ala Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Leu Trp Arg Gly Asn Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  45
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-9 VH Sequence

<400>  45

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Ser Ala Ala Tyr Thr Arg Tyr Ala Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Met Trp Arg Gly Asn Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  46
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-9, hGBA-10 VL Sequence

<400>  46

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  47
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IMAB362 HC full


<220>
<221>  MISC_FEATURE
<222>  (448)..(448)
<223>  Xaa is Lys or Arg

<400>  47

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Tyr Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ser Trp Arg Gly Asn Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Xaa 
        435                 440                 445             


<210>  48
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IMAB362 Light Chain full

<400>  48

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  49
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-1 Heavy Chain Sequence


<220>
<221>  MISC_FEATURE
<222>  (448)..(448)
<223>  Xaa is Lys or Arg

<400>  49

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Tyr Pro Gly Ala Ser Asp Thr Arg Tyr Ala Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Trp Arg Gly Asn Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Xaa 
        435                 440                 445             


<210>  50
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-1, hGBA-2, hGBA-6, hGBA-8 Light Chain Sequence

<400>  50

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  51
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-2 Heavy Chain Sequence


<220>
<221>  MISC_FEATURE
<222>  (448)..(448)
<223>  Xaa is Lys or Arg

<400>  51

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Tyr Pro Gly Asp Ala Asp Thr Arg Tyr Ala Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Met Trp Arg Gly Asn Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Xaa 
        435                 440                 445             


<210>  52
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-3 Heavy Chain Sequence


<220>
<221>  MISC_FEATURE
<222>  (448)..(448)
<223>  Xaa is Lys or Arg

<400>  52

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Ala Ser Asp Thr Asn Tyr Ala Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Trp Arg Gly Asn Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Xaa 
        435                 440                 445             


<210>  53
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-3 Light Chain Sequence

<400>  53

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  54
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-4 Heavy Chain Sequence


<220>
<221>  MISC_FEATURE
<222>  (448)..(448)
<223>  Xaa is Lys or Arg

<400>  54

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ala Tyr Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Leu Trp Arg Gly Asn Ser Phe Asp Ala Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Xaa 
        435                 440                 445             


<210>  55
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-4 Light Chain Sequence

<400>  55

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  56
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-5 Heavy Chain Sequence


<220>
<221>  MISC_FEATURE
<222>  (448)..(448)
<223>  Xaa is Lys or Arg

<400>  56

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Ala Ala Tyr Thr Arg Tyr Ala Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Trp Arg Gly Asn Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Xaa 
        435                 440                 445             


<210>  57
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-5 Light Chain Sequence

<400>  57

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  58
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-6 Heavy Chain Sequence


<220>
<221>  MISC_FEATURE
<222>  (448)..(448)
<223>  Xaa is Lys or Arg

<400>  58

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Tyr Pro Gly Ala Ser Tyr Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gln Trp Arg Gly Asn Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Xaa 
        435                 440                 445             


<210>  59
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-7 Heavy Chain Sequence


<220>
<221>  MISC_FEATURE
<222>  (448)..(448)
<223>  Xaa is Lys or Arg

<400>  59

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Tyr Pro Gly Glu Ala Tyr Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Leu Trp Arg Gly Asn Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Xaa 
        435                 440                 445             


<210>  60
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-7 Light Chain Sequence

<400>  60

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  61
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-8 Heavy Chain Sequence


<220>
<221>  MISC_FEATURE
<222>  (448)..(448)
<223>  Xaa is Lys or Arg

<400>  61

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Tyr Pro Ser Glu Ser Tyr Thr Asn Tyr Ala Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Leu Trp Arg Gly Asn Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Xaa 
        435                 440                 445             


<210>  62
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-9 Heavy Chain Sequence


<220>
<221>  MISC_FEATURE
<222>  (448)..(448)
<223>  Xaa is Lys or Arg

<400>  62

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Ser Ala Ala Tyr Thr Arg Tyr Ala Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Met Trp Arg Gly Asn Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Xaa 
        435                 440                 445             


<210>  63
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGBA-9 Light Chain Sequence

<400>  63

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  64
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Constant heavy chain - CH1 + Fc domain


<220>
<221>  MISC_FEATURE
<222>  (330)..(330)
<223>  Xaa is Lys or Arg

<400>  64

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Xaa 
                325                 330 


<210>  65
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Constant light chain region

<400>  65

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  66
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Constant heavy chain region CH1 and Fc region with reduced Fc 
       gamma R binding having the L234A/L235A mutations


<220>
<221>  MISC_FEATURE
<222>  (330)..(330)
<223>  Xaa is Lys or Arg

<400>  66

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Xaa 
                325                 330 


<210>  67
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Constant heavy chain region CH1 and Fc region having the 
       L234A/L235A/P329G mutations in the constant heavy chain region 
       CH1 and Fc region with even further reduced Fc gamma R binding


<220>
<221>  MISC_FEATURE
<222>  (330)..(330)
<223>  Xaa is Lys or Arg

<400>  67

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Xaa 
                325                 330 


<210>  68
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extracellular domain of CLDN18.2, independent of 
       glycosylation

<400>  68

Asp Gln Trp Ser Thr Gln Asp Leu Tyr Asn 
1               5                   10  


<210>  69
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extracellular domain of CLDN18.2, mainly 
       unglycosylated

<400>  69

Asn Asn Pro Val Thr Ala Val Phe Asn Tyr Gln 
1               5                   10      


<210>  70
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extracellular domain of CLDN18.2, unglycosylated

<400>  70

Ser Thr Gln Asp Leu Tyr Asn Asn Pro Val Thr Ala Val Phe 
1               5                   10                  


<210>  71
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pan-CLDN18 peptide

<400>  71

Thr Asn Phe Trp Met Ser Thr Ala Asn Met Tyr Thr Gly 
1               5                   10              


<210>  72
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide sequence disclosed by WO2005/113587 against specific 
       epitopes on CLDN18.2

<400>  72

Ala Leu Met Ile Val Gly Ile Val Leu Gly Ala Ile Gly Leu Leu Val 
1               5                   10                  15      


<210>  73
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide sequence disclosed by WO2005/113587 against specific 
       epitopes on CLDN18.2

<400>  73

Arg Ile Gly Ser Met Glu Asp Ser Ala Lys Ala Asn Met Thr Leu Thr 
1               5                   10                  15      


Ser Gly Ile Met Phe Ile Val Ser 
            20                  


<210>  74
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide including the first extracellular domain of CLDN18.2 with
       N- and C-terminal extensions

<400>  74

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Arg Arg Ala Arg Arg Thr 
            20                  25                  30          


Lys Leu Gly Thr Glu Leu Gly Ser Thr Pro Val Trp Trp Asn Ser Ala 
        35                  40                  45              


Asp Gly Arg Met Asp Gln Trp Ser Thr Gln Asp Leu Tyr Asn Asn Pro 
    50                  55                  60                  


Val Thr Ala Val Phe Asn Tyr Gln Gly Leu Trp Arg Ser Cys Val Arg 
65                  70                  75                  80  


Glu Ser Ser Gly Phe Thr Glu Cys Arg Gly Tyr Phe Thr Leu Leu Gly 
                85                  90                  95      


Leu Pro Ala Met Leu Gln Ala Val Arg Ala Ala Ile Gln His Ser Gly 
            100                 105                 110         


Gly Arg Ser Arg Arg Ala Arg Thr Lys Thr His Leu Arg Arg Gly Ser 
        115                 120                 125             


Glu 
    


<210>  75
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Overlapping peptides of CLDN18.2 within the first extracellular 
       domain

<400>  75

Met Asp Gln Trp Ser Thr Gln Asp Leu Tyr Asn Asn Pro Val Thr 
1               5                   10                  15  


<210>  76
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Overlapping peptides of CLDN18.2 within the first extracellular 
       domain

<400>  76

Leu Tyr Asn Asn Pro Val Thr Ala Val Phe Asn Tyr Gln Gly Leu 
1               5                   10                  15  


<210>  77
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Overlapping peptides of CLDN18.2 within the first extracellular 
       domain

<400>  77

Val Phe Asn Tyr Gln Gly Leu Trp Arg Ser Cys Val Arg Glu Ser 
1               5                   10                  15  


<210>  78
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Overlapping peptides of CLDN18.2 within the first extracellular 
       domain

<400>  78

Gln Gly Leu Trp Arg Ser Cys Val Arg Glu Ser Ser Gly Phe Thr 
1               5                   10                  15  


<210>  79
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Overlapping peptides of CLDN18.2 within the first extracellular 
       domain

<400>  79

Arg Ser Cys Val Arg Glu Ser Ser Gly Phe Thr Glu Cys Arg Gly 
1               5                   10                  15  


<210>  80
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope of antibody of WO2013/167259 binding to C-terminal 
       epitopes of CLDN18.2

<400>  80

Thr Glu Asp Glu Val Gln Ser Tyr Pro Ser Lys His Asp Tyr Val 
1               5                   10                  15  


<210>  81
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope of antibody of WO2013/167259 binding to C-terminal 
       epitopes of CLDN18.2

<400>  81

Glu Val Gln Ser Tyr Pro Ser Lys His Asp Tyr Val 
1               5                   10          


<210>  82
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus including IMAB362 HC CDR1


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  T or S

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  G or N

<400>  82

Gly Tyr Xaa Phe Thr Ser Tyr Trp Ile Xaa 
1               5                   10  


<210>  83
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus including IMAB362 HC CDR2


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  N or I

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  S or G

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  A, E or D

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  A or S

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Y or D

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  N or R

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  A, N or S

<400>  83

Gly Xaa Ile Tyr Pro Xaa Xaa Xaa Xaa Thr Xaa Tyr Xaa 
1               5                   10              


<210>  84
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus including IMAB362 HC CDR3


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  A or T

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  L, M, I, S or Q

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  A or Y

<400>  84

Xaa Arg Xaa Trp Arg Gly Asn Ser Phe Asp Xaa 
1               5                   10      


<210>  85
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-1, hGBA-3 HCDR1 Sequence

<400>  85
ggctatagct ttacatcata ttggattgga                                        30


<210>  86
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-1 HCDR2 Sequence

<400>  86
gggaacattt accctggggc atcggatacg cgatacgca                              39


<210>  87
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-1 HCDR3 Sequence

<400>  87
gcgagacttt ggcgggggaa tagcttcgac tac                                    33


<210>  88
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-1 LCDR1 Sequence

<400>  88
aaaagctccc aaagcctatt gaactcggga aaccaaaaga attacttggc a                51


<210>  89
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-1 LCDR2 Sequence

<400>  89
tgggcaagca cccgagagag c                                                 21


<210>  90
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-1 LCDR3 Sequence

<400>  90
caaaacgact attcataccc attcaca                                           27


<210>  91
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-2 HCDR1 Sequence

<400>  91
ggatattcat ttacaagcta ctggatcgga                                        30


<210>  92
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-2 HCDR2 Sequence

<400>  92
ggaaatatat accccggaga cgcggacacg agatacgca                              39


<210>  93
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-2 HCDR3 Sequence

<400>  93
gcgcggatgt ggcgcggcaa tagctttgac tac                                    33


<210>  94
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-3 HCDR2 Sequence

<400>  94
gggatcatct atccgggggc atccgatacc aactatgcg                              39


<210>  95
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-3 HCDR3 Sequence

<400>  95
gctaggattt ggcgaggaaa tagctttgat tat                                    33


<210>  96
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-3 LCDR1 Sequence

<400>  96
aagagctcgc aaagtttgct gaactccggg aaccaaaaga attacctggc a                51


<210>  97
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-3 LCDR2 Sequence

<400>  97
tgggcatcaa cgcgggaaag c                                                 21


<210>  98
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-3 LCDR3 Sequence

<400>  98
caaaacgact actcctatcc gctgacc                                           27


<210>  99
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-4 HCDR1 Sequence

<400>  99
ggatactcat ttacatcata ctggatagga                                        30


<210>  100
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-4 HCDR2 Sequence

<400>  100
gggattatat accccggcga cgcttacact cgatattcg                              39


<210>  101
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-4 HCDR3 Sequence

<400>  101
acgaggctat ggagggggaa tagctttgat gcc                                    33


<210>  102
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-4 LCDR1 Sequence

<400>  102
aagagctccc aaagcctatt gaactcggga aatcaaaaga attatctgac a                51


<210>  103
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-4 LCDR2 Sequence

<400>  103
tgggcctcga caagggagag c                                                 21


<210>  104
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-4 LCDR3 Sequence

<400>  104
caaaatgact actcataccc gctgaca                                           27


<210>  105
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-5 HCDR1 Sequence

<400>  105
ggatatagct ttacgagcta ctggatcgga                                        30


<210>  106
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-5 HCDR2 Sequence

<400>  106
gggataatat accccggagc ggcatacacg agatatgcg                              39


<210>  107
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-5 HCDR3 Sequence

<400>  107
gcgagactat ggcgcgggaa ctcatttgat tac                                    33


<210>  108
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-5 LCDR1 Sequence

<400>  108
aaatcatcgc aatcattgct aaattcgggg aaccaaaaga attatttggc a                51


<210>  109
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-5 LCDR2 Sequence

<400>  109
tgggcatcca cgagagaatc g                                                 21


<210>  110
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-5 LCDR3 Sequence

<400>  110
caacaagatt attcataccc atttaca                                           27


<210>  111
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-6 HCDR1 Sequence

<400>  111
ggatatacat ttacatctta ctggatcgga                                        30


<210>  112
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-6 HCDR2 Sequence

<400>  112
gggaacattt atcctggcgc gagctatacg cgctat                                 36


<210>  113
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-6 HCDR3 Sequence

<400>  113
acccggcaat ggaggggcaa tagctttgac tac                                    33


<210>  114
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-7 HCDR1 Sequence

<400>  114
ggatattcct ttacatcata ctggatcggc                                        30


<210>  115
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-7 HCDR2 Sequence

<400>  115
gggaacatat atcccggaga agcctatacg agatactcg                              39


<210>  116
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-7 HCDR3 Sequence

<400>  116
acgcgactat ggaggggaaa tagctttgac tat                                    33


<210>  117
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-7 LCDR1 Sequence

<400>  117
aagagctccc aatcagtcct gaactctggg aatcaaaaga attacctgac a                51


<210>  118
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-7, h-GBA 9 LCDR2 Sequence

<400>  118
tgggcgagca cgagggagag c                                                 21


<210>  119
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-7 LCDR3 Sequence

<400>  119
caaaatgatt attcataccc cttcaca                                           27


<210>  120
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-8 HCDR1 Sequence

<400>  120
ggatactcct ttacatcata ttggatcgga                                        30


<210>  121
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-8 HCDR2 Sequence

<400>  121
ggaaacatat atccgagcga atcatatacg aactacgcg                              39


<210>  122
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-8 HCDR3 Sequence

<400>  122
acgaggctat ggagggggaa tagcttcgac tat                                    33


<210>  123
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-9 HCDR1 Sequence

<400>  123
ggatatacat tcacgagcta ctggatagga                                        30


<210>  124
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-9 HCDR2 Sequence

<400>  124
ggaatcatat atccttccgc ggcatatacg cgatatgcg                              39


<210>  125
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-9 HCDR3 Sequence

<400>  125
acgcggatgt ggaggggaaa tagctttgat tac                                    33


<210>  126
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-9 LCDR1 Sequence

<400>  126
aagagctcgc aatcggtcct gaatagcggg aaccaaaaga attatctggc c                51


<210>  127
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-9 LCDR3 Sequence

<400>  127
caacaagact actcataccc atttaca                                           27


<210>  128
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-1 VH Sequence

<400>  128
gaagtccaac tggtccaatc cggcgcggag gttaagaagc ccggagaatc gctgaagatc       60

tcatgcaaag ggagcggcta tagctttaca tcatattgga ttggatgggt caggcaaatg      120

ccggggaagg ggctggaatg gatggggaac atttaccctg gggcatcgga tacgcgatac      180

gcacctagct ttcaagggca agtcacaatt tcggcggaca agagcatctc aacggcatac      240

ctgcaatggt cgagcttgaa ggcatctgat actgcaatgt actactgcgc gagactttgg      300

cgggggaata gcttcgacta ctgggggcag ggtaccctgg ttacggtctc gagc            354


<210>  129
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-1, h-GBA 2, h-GBA 6, h-GBA 8 VL Sequence

<400>  129
gacattgtga tgacgcaaag ccccgattcg ctggctgtat cgctagggga gcgcgctacg       60

atcaattgca aaagctccca aagcctattg aactcgggaa accaaaagaa ttacttggca      120

tggtatcaac aaaaaccggg gcaaccgccg aagctgctga tctattgggc aagcacccga      180

gagagcggtg tcccggaccg atttagcggg agcggatcgg gcaccgactt cacgctgaca      240

ataagctcat tgcaagccga ggatgtggcg gtctattatt gccaaaacga ctattcatac      300

ccattcacat tcgggcaagg taccaaggtc gagatcaag                             339


<210>  130
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-2 VH Sequence

<400>  130
gaagtccaac tggtccaatc tggagcggaa gtcaagaagc ctggggagag cctgaaaatt       60

tcatgcaagg ggagcggata ttcatttaca agctactgga tcggatgggt ccggcaaatg      120

ccggggaagg gcttggaatg gatgggaaat atataccccg gagacgcgga cacgagatac      180

gcaccgagct ttcaagggca ggtcaccatt agcgctgata aatcgatttc aaccgcatat      240

ctgcaatggt catcgctgaa ggcctccgac accgcgatgt actattgcgc gcggatgtgg      300

cgcggcaata gctttgacta ctgggggcag ggtaccctcg tcacggtctc gagc            354


<210>  131
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-3 VH Sequence

<400>  131
gaggtccaac tggtccaaag cggcgcggag gtcaagaagc cgggagaatc cctgaagatt       60

agctgcaaag gctccggcta tagctttaca tcatattgga tcggatgggt cagacaaatg      120

ccgggaaagg gacttgaatg gatggggatc atctatccgg gggcatccga taccaactat      180

gcgccgagct tccaagggca ggtcacgata tccgcggata aatcgattag caccgcatat      240

ctgcaatgga gctcgctgaa ggcatccgac accgcgatgt actactgcgc taggatttgg      300

cgaggaaata gctttgatta ttgggggcag ggtacccttg tcacggtctc gagc            354


<210>  132
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-3 VL Sequence

<400>  132
gacattgtca tgacgcaaag ccccgactcg ctggccgtct cactggggga gcgggcgaca       60

atcaactgca agagctcgca aagtttgctg aactccggga accaaaagaa ttacctggca      120

tggtatcaac aaaagccggg gcaacccccg aagctgctga tatattgggc atcaacgcgg      180

gaaagcggag tcccggatag atttagcgga tctggatcgg ggaccgactt cacgctgacg      240

atatctagcc ttcaagccga ggatgtggct gtatattatt gccaaaacga ctactcctat      300

ccgctgacct tcgggcaagg taccaaggtc gagatcaag                             339


<210>  133
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-4 VH Sequence

<400>  133
gaagtccaac tagtccaaag cggagccgaa gtcaagaaac cgggggagag ccttaagatc       60

tcatgcaagg ggagcggata ctcatttaca tcatactgga taggatgggt cagacaaatg      120

cccggcaagg ggctggaatg gatggggatt atataccccg gcgacgctta cactcgatat      180

tcgccatcat tccaagggca ggtcacgata tcggccgata aatcgatatc cacggcatac      240

ctgcaatgga gctcactgaa agcatctgat acggcaatgt attattgcac gaggctatgg      300

agggggaata gctttgatgc ctgggggcag ggtaccctgg tcacggtctc gagc            354


<210>  134
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-4 VL Sequence

<400>  134
gacatagtta tgacacaatc gccggatagc ctcgcggtca gccttggaga gcgggcgacg       60

atcaactgca agagctccca aagcctattg aactcgggaa atcaaaagaa ttatctgaca      120

tggtatcaac aaaagccggg gcaaccaccg aaactgctga tctattgggc ctcgacaagg      180

gagagcggag tcccggaccg cttctctgga tcgggaagcg ggactgactt cacgctgacc      240

ataagctcgc tgcaagccga ggacgtcgcc gtctattatt gccaaaatga ctactcatac      300

ccgctgacat ttggccaagg taccaaggtc gagatcaag                             339


<210>  135
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-5 VH Sequence

<400>  135
gaggtgcaac tggtacaatc cggggcggaa gtgaagaagc cgggggaatc gctgaagata       60

agctgcaaag gctctggata tagctttacg agctactgga tcggatgggt caggcaaatg      120

ccggggaagg gactggaatg gatggggata atataccccg gagcggcata cacgagatat      180

gcgccgagct tccaagggca agtgacaata agcgcggaca aatcgattag cacggcatat      240

ctgcaatggt cctcgctgaa ggcgagcgat accgcaatgt actattgcgc gagactatgg      300

cgcgggaact catttgatta ctgggggcag ggtaccctag tgacggtctc gagc            354


<210>  136
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-5 VL Sequence

<400>  136
gacattgtca tgacgcaaag cccggatagc ctggctgtat cgctggggga gagagcgacg       60

atcaactgca aatcatcgca atcattgcta aattcgggga accaaaagaa ttatttggca      120

tggtatcaac aaaagccggg gcaaccgccg aaactgctga tttactgggc atccacgaga      180

gaatcgggag tcccggaccg atttagcgga tctgggagcg ggaccgattt cacgctgacc      240

attagctcgc tgcaagcgga ggatgtggcg gtctattact gccaacaaga ttattcatac      300

ccatttacat ttgggcaagg taccaaggtc gagatcaag                             339


<210>  137
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-6 VH Sequence

<400>  137
gaagtacaat tggttcaatc gggggccgaa gtcaagaagc cgggggaatc gctgaagata       60

tcctgcaagg ggagcggata tacatttaca tcttactgga tcggatgggt cagacaaatg      120

cccggaaagg ggcttgaatg gatggggaac atttatcctg gcgcgagcta tacgcgctat      180

agcccgagct tccaagggca ggtcacgatt agcgccgaca agagcatttc gacggcatac      240

ctgcaatgga gctcgctgaa agcatcggat acggcaatgt attactgcac ccggcaatgg      300

aggggcaata gctttgacta ctgggggcag ggtaccctag tcacggtctc gagc            354


<210>  138
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-7 VH Sequence

<400>  138
gaagttcaat tggtccaatc tggagccgaa gtcaagaagc ccggagaatc gctgaagatt       60

agctgcaagg ggagcggata ttcctttaca tcatactgga tcggctgggt cagacaaatg      120

cccggaaagg gactggaatg gatggggaac atatatcccg gagaagccta tacgagatac      180

tcgccatcat ttcaaggaca ggtcaccata agcgcggaca agagcataag caccgcatac      240

ctgcaatgga gctcgctgaa ggcatcggac accgccatgt attactgcac gcgactatgg      300

aggggaaata gctttgacta ttgggggcag ggtaccttag tcacggtctc gagc            354


<210>  139
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-7 VL Sequence

<400>  139
gatatagtaa tgactcaatc acccgatagc ttggctgtga gcctgggaga aagagctaca       60

atcaactgca agagctccca atcagtcctg aactctggga atcaaaagaa ttacctgaca      120

tggtatcaac aaaagcccgg acaaccgccg aagctgctga tctactgggc gagcacgagg      180

gagagcggag tcccggatcg attttctggc tccgggagcg gaaccgactt cacactgact      240

attagctcgc tgcaagcgga ggacgtcgcc gtctactatt gccaaaatga ttattcatac      300

cccttcacat ttgggcaagg taccaaggtc gagatcaag                             339


<210>  140
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-8 VH Sequence

<400>  140
gaggtgcaac tagtgcaatc gggggccgaa gtgaagaaac ctggggaatc gctgaagata       60

tcatgcaagg ggagcggata ctcctttaca tcatattgga tcggatgggt caggcaaatg      120

ccggggaagg ggctggaatg gatgggaaac atatatccga gcgaatcata tacgaactac      180

gcgccgagct ttcaaggaca agtcacgata tccgcggata aatcgatatc gaccgcatac      240

ctgcaatgga gctcgctgaa ggcttccgac actgcgatgt attactgcac gaggctatgg      300

agggggaata gcttcgacta ttgggggcag ggtaccctgg tgacggtctc gagc            354


<210>  141
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-9 VH Sequence

<400>  141
gaagtccaat tagtccaatc gggggccgag gtcaagaagc cgggggaatc gctcaagata       60

agctgcaagg gatcgggata tacattcacg agctactgga taggatgggt caggcaaatg      120

ccggggaagg ggctggaatg gatgggaatc atatatcctt ccgcggcata tacgcgatat      180

gcgccatcat ttcaaggaca ggtcacgata agcgccgaca agagcattag caccgcatac      240

ctgcaatggt cgagccttaa ggcatcggac accgcgatgt actactgcac gcggatgtgg      300

aggggaaata gctttgatta ctgggggcag ggtaccctag tcacggtctc gagc            354


<210>  142
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGBA-9 VL Sequence

<400>  142
gacatcgtca tgacgcaaag cccggactcg ctggcggtct cgctggggga gcgggccaca       60

ataaattgca agagctcgca atcggtcctg aatagcggga accaaaagaa ttatctggcc      120

tggtatcaac aaaagccggg gcaaccaccg aagctgctaa tctattgggc gagcacgagg      180

gagagcggag tccccgatcg atttagcgga tcgggaagcg ggaccgattt cacgctgacg      240

atttcgagcc tacaagccga ggatgtggcg gtctattact gccaacaaga ctactcatac      300

ccatttacat ttggacaagg taccaaggtc gagatcaag                             339


<210>  143
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LPXTGG tag


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is any of the 20 natural amino acids

<400>  143

Leu Pro Xaa Thr Gly Gly 
1               5       


<210>  144
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGGGSLPXTGG tag


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is any of the 20 natural amino acids

<400>  144

Gly Gly Gly Gly Ser Leu Pro Xaa Thr Gly Gly 
1               5                   10      


<210>  145
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  
hGBA-6 HC full LALA


<220>
<221>  MISC_FEATURE
<222>  (448)..(448)
<223>  Xaa is Lys or Arg

<400>  145

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Tyr Pro Gly Ala Ser Tyr Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gln Trp Arg Gly Asn Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Xaa 
        435                 440                 445             


<210>  146
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  
hGBA-6 HC full LALAPG


<220>
<221>  MISC_FEATURE
<222>  (448)..(448)
<223>  Xaa is Lys or Arg

<400>  146

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Tyr Pro Gly Ala Ser Tyr Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gln Trp Arg Gly Asn Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Xaa 
        435                 440                 445             


<210>  147
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LPXTG tag


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is any of the 20 natural amino acids

<220>
<221>  REPEAT
<222>  (5)..(5)
<223>  oligoglycine may comprise 1-21 repeats

<400>  147

Leu Pro Xaa Thr Gly 
1               5   


<210>  148
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LPXAG tag


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is any of the 20 natural amino acids

<220>
<221>  REPEAT
<222>  (5)..(5)
<223>  oligoglycine may comprise 1-21 repeats

<400>  148

Leu Pro Xaa Ala Gly 
1               5   


<210>  149
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LPXSG tag


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is any of the 20 natural amino acids

<220>
<221>  REPEAT
<222>  (5)..(5)
<223>  oligoglycine may comprise 1-21 repeats

<400>  149

Leu Pro Xaa Ser Gly 
1               5   


<210>  150
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAXTG tag


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is any of the 20 natural amino acids

<220>
<221>  REPEAT
<222>  (5)..(5)
<223>  oligoglycine may comprise 1-21 repeats

<400>  150

Leu Ala Xaa Thr Gly 
1               5   


<210>  151
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LPXTA tag


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is any of the 20 natural amino acids

<220>
<221>  REPEAT
<222>  (5)..(5)
<223>  oligoalanine may comprise 1-21 repeats

<400>  151

Leu Pro Xaa Thr Ala 
1               5   


<210>  152
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPQTG tag


<220>
<221>  REPEAT
<222>  (5)..(5)
<223>  oligoglycine may comprise 1-21 repeats

<400>  152

Asn Pro Gln Thr Gly 
1               5   


<210>  153
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPQTN tag


<220>
<221>  REPEAT
<222>  (5)..(5)
<223>  oligoasparagine may comprise 1-21 repeats

<400>  153

Asn Pro Gln Thr Asn 
1               5   


<210>  154
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LPQTGG tag

<400>  154

Leu Pro Gln Thr Gly Gly 
1               5       


<210>  155
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LPETGG tag

<400>  155

Leu Pro Glu Thr Gly Gly 
1               5       


<210>  156
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGGGS oligopeptide


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  oligopeptide may comprise 1-5 repeats

<400>  156

Gly Gly Gly Gly Ser 
1               5   


<210>  157
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGGGG oligopeptide

<400>  157

Gly Gly Gly Gly Gly 
1               5   


<210>  158
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGGGSLPQTGG tag

<400>  158

Gly Gly Gly Gly Ser Leu Pro Gln Thr Gly Gly 
1               5                   10      


<210>  159
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LPQTG tag

<400>  159

Leu Pro Gln Thr Gly 
1               5   


