                         SEQUENCE LISTING

<110>  UCB Biopharma SRL
 
<120>  ANTIBODIES

<130>  PF0251-WO-PCT

<160>  106   

<170>  PatentIn version 3.5

<210>  1
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ala Leu Gln Lys Ser Val Ser Ser Phe Leu Met Gly Thr Leu 
1               5                   10                  15      


Ala Thr Ser Cys Leu Leu Leu Leu Ala Leu Leu Val Gln Gly Gly Ala 
            20                  25                  30          


Ala Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln 
        35                  40                  45              


Gln Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser 
    50                  55                  60                  


Leu Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe 
65                  70                  75                  80  


His Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu 
                85                  90                  95      


Asn Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln 
            100                 105                 110         


Pro Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg 
        115                 120                 125             


Leu Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn 
    130                 135                 140                 


Val Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu 
145                 150                 155                 160 


Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn 
                165                 170                 175     


Ala Cys Ile 
            


<210>  2
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
        35                  40                  45              


Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Asn 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu 
                85                  90                  95      


Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala 
    130                 135                 140                 


Cys Ile 
145     


<210>  3
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His tag IL22

<400>  3

Met Gly Ser Ser His His His His His His Ser Ser Gly Glu Asn Leu 
1               5                   10                  15      


Tyr Phe Gln Gly Ser Gln Gly Gly Ala Ala Ala Pro Ile Ser Ser His 
            20                  25                  30          


Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln Pro Tyr Ile Thr Asn Arg 
        35                  40                  45              


Thr Phe Met Leu Ala Lys Glu Ala Ser Leu Ala Asp Asn Asn Thr Asp 
    50                  55                  60                  


Val Arg Leu Ile Gly Glu Lys Leu Phe His Gly Val Ser Met Ser Glu 
65                  70                  75                  80  


Arg Cys Tyr Leu Met Lys Gln Val Leu Asn Phe Thr Leu Glu Glu Val 
                85                  90                  95      


Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro Tyr Met Gln Glu Val Val 
            100                 105                 110         


Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu Ser Thr Cys His Ile Glu 
        115                 120                 125             


Gly Asp Asp Leu His Ile Gln Arg Asn Val Gln Lys Leu Lys Asp Thr 
    130                 135                 140                 


Val Lys Lys Leu Gly Glu Ser Gly Glu Ile Lys Ala Ile Gly Glu Leu 
145                 150                 155                 160 


Asp Leu Leu Phe Met Ser Leu Arg Asn Ala Cys Ile 
                165                 170         


<210>  4
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  4

Gly Ser Gln Gly Gly Ala Ala Ala Pro Ile Ser Ser His Cys Arg Leu 
1               5                   10                  15      


Asp Lys Ser Asn Phe Gln Gln Pro Tyr Ile Thr Asn Arg Thr Phe Met 
            20                  25                  30          


Leu Ala Lys Glu Ala Ser Leu Ala Asp Asn Asn Thr Asp Val Arg Leu 
        35                  40                  45              


Ile Gly Glu Lys Leu Phe His Gly Val Ser Met Ser Glu Arg Cys Tyr 
    50                  55                  60                  


Leu Met Lys Gln Val Leu Asn Phe Thr Leu Glu Glu Val Leu Phe Pro 
65                  70                  75                  80  


Gln Ser Asp Arg Phe Gln Pro Tyr Met Gln Glu Val Val Pro Phe Leu 
                85                  90                  95      


Ala Arg Leu Ser Asn Arg Leu Ser Thr Cys His Ile Glu Gly Asp Asp 
            100                 105                 110         


Leu His Ile Gln Arg Asn Val Gln Lys Leu Lys Asp Thr Val Lys Lys 
        115                 120                 125             


Leu Gly Glu Ser Gly Glu Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu 
    130                 135                 140                 


Phe Met Ser Leu Arg Asn Ala Cys Ile 
145                 150             


<210>  5
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR seq

<400>  5

Gln Ala Ser Glu Asp Ile Tyr Thr Asn Leu Ala 
1               5                   10      


<210>  6
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR seq

<400>  6

Trp Ala Ser Thr Leu Ala Ser 
1               5           


<210>  7
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR seq

<400>  7

Gln Ala Ser Val Tyr Gly Asn Ala Ala Asp Ser Arg Tyr Thr 
1               5                   10                  


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR seq

<400>  8

Gly Phe Ser Leu Ser Ser Tyr Ala Met Ile 
1               5                   10  


<210>  9
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR seq

<400>  9

Ile Ile Asp Ile Glu Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR seq

<400>  10

Asp Arg Phe Val Gly Val Asp Ile Phe Asp Pro 
1               5                   10      


<210>  11
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR seq

<400>  11

Gln Ala Cys Val Tyr Gly Asn Ser Ala Asp Ser Arg Tyr Thr 
1               5                   10                  


<210>  12
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR seq

<400>  12

Gln Ala Ser Val Tyr Gly Asn Ser Ala Asp Ser Arg Tyr Thr 
1               5                   10                  


<210>  13
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR seq

<400>  13

Gln Ala Val Val Tyr Gly Asn Ser Ala Asp Ser Arg Tyr Thr 
1               5                   10                  


<210>  14
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR seq

<400>  14

Gln Ala Cys Val Tyr Gly Asn Ala Ala Asp Ser Arg Tyr Thr 
1               5                   10                  


<210>  15
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR seq

<400>  15

Gln Ala Val Val Tyr Gly Asn Ala Ala Asp Ser Arg Tyr Thr 
1               5                   10                  


<210>  16
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR seq

<400>  16

Gln Ala Cys Val Tyr Gly Asp Ser Ala Asp Ser Arg Tyr Thr 
1               5                   10                  


<210>  17
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR seq

<400>  17

Gln Ala Ser Val Tyr Gly Asp Ser Ala Asp Ser Arg Tyr Thr 
1               5                   10                  


<210>  18
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR seq

<400>  18

Gln Ala Val Val Tyr Gly Asp Ser Ala Asp Ser Arg Tyr Thr 
1               5                   10                  


<210>  19
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR seq

<400>  19

Ile Ile Asp Ile Asp Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  20
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR seq

<400>  20

Ile Ile Asp Ile Asp Ala Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  21
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR seq

<400>  21

Asp Arg Phe Val Gly Val Asp Ile Phe Glu Pro 
1               5                   10      


<210>  22
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11041 gL6 C91S S96A (gL13) V-region

<400>  22

Ala Val Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Ile Tyr Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ala Ser Val Tyr Gly Asn Ala 
                85                  90                  95      


Ala Asp Ser Arg Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  23
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11041 gL6 C91S S96A (gL13) V-region

<400>  23
gccgtccaac tgactcagtc cccgagctca ctttccgcga gcgtgggaga tcgcgtgacc       60

attacgtgcc aggcctcgga ggacatctac accaacctcg cctggtatca acagaagcct      120

ggcaaagctc ccaagctgtt gatctactgg gcctccactc tggcctccgg agtgccttcg      180

cggttctccg gttctggatc aggcaccgac ttcaccctga caatcagcag cctccagccg      240

gaagattttg ccacttacta ctgccaagca tccgtctacg ggaacgcagc ggactccaga      300

tataccttcg gcgggggaac caaagtggag attaagcgta cg                         342


<210>  24
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11041 gH5 D54E (gH14) V-region

<400>  24

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Asp Ile Glu Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Arg Phe Val Gly Val Asp Ile Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  25
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11041 gH5 D54E (gH14) V-region

<400>  25
gaggtgcagc tcgtggaaag cggaggagga ctggtgcagc caggagggtc cttgcggctt       60

agctgtgccg tgtccggctt ctccctgtcc tcctacgcca tgatctgggt ccgccaagct      120

cctgggaagg gcctcgaatg gattggtatt atcgacatcg agggatcaac ctactacgcc      180

tcgtgggcca agggacggtt caccatctcg cgggacaact ccaagaacac tgtgtatctg      240

cagatgaaca gcctgagggc agaagatacc gccgtgtact actgcgcgag agatcgcttc      300

gtgggcgtgg acatctttga cccgtggggt caaggcaccc tggtcactgt ctcgagc         357


<210>  26
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11041gL13 Light chain

<400>  26

Ala Val Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Ile Tyr Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ala Ser Val Tyr Gly Asn Ala 
                85                  90                  95      


Ala Asp Ser Arg Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  27
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11041gL13 Light chain

<400>  27
gccgtccaac tgactcagtc cccgagctca ctttccgcga gcgtgggaga tcgcgtgacc       60

attacgtgcc aggcctcgga ggacatctac accaacctcg cctggtatca acagaagcct      120

ggcaaagctc ccaagctgtt gatctactgg gcctccactc tggcctccgg agtgccttcg      180

cggttctccg gttctggatc aggcaccgac ttcaccctga caatcagcag cctccagccg      240

gaagattttg ccacttacta ctgccaagca tccgtctacg ggaacgcagc ggactccaga      300

tataccttcg gcgggggaac caaagtggag attaagcgta cggtggccgc tccctccgtg      360

ttcatcttcc caccctccga cgagcagctg aagtccggca ccgcctccgt cgtgtgcctg      420

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      480

tccggcaact cccaggaatc cgtcaccgag caggactcca aggacagcac ctactccctg      540

tcctccaccc tgaccctgtc caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccacc agggcctgtc cagccccgtg accaagtcct tcaaccgggg cgagtgc         657


<210>  28
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11041gH14 Fab Heavy chain

<400>  28

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Asp Ile Glu Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Arg Phe Val Gly Val Asp Ile Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220         


<210>  29
<211>  666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11041gH14 Fab Heavy chain

<400>  29
gaggtgcagc tcgtggaaag cggaggagga ctggtgcagc caggagggtc cttgcggctt       60

agctgtgccg tgtccggctt ctccctgtcc tcctacgcca tgatctgggt ccgccaagct      120

cctgggaagg gcctcgaatg gattggtatt atcgacatcg agggatcaac ctactacgcc      180

tcgtgggcca agggacggtt caccatctcg cgggacaact ccaagaacac tgtgtatctg      240

cagatgaaca gcctgagggc agaagatacc gccgtgtact actgcgcgag agatcgcttc      300

gtgggcgtgg acatctttga cccgtggggt caaggcaccc tggtcactgt ctcgagcgcg      360

tccacaaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc      420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccagtgac ggtgtcgtgg      480

aactcaggtg ccctgaccag cggcgttcac accttcccgg ctgtcctaca gtcttcagga      540

ctctactccc tgagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac      600

atctgcaacg tgaatcacaa gcccagcaac accaaggtcg ataagaaagt tgagcccaaa      660

tcttgt                                                                 666


<210>  30
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11041gH14 heavy chain (IgG1)

<400>  30

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Asp Ile Glu Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Arg Phe Val Gly Val Asp Ile Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  31
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11041gH14 heavy chain (IgG1)

<400>  31
gaggtgcagc tcgtggaaag cggaggagga ctggtgcagc caggagggtc cttgcggctt       60

agctgtgccg tgtccggctt ctccctgtcc tcctacgcca tgatctgggt ccgccaagct      120

cctgggaagg gcctcgaatg gattggtatt atcgacatcg agggatcaac ctactacgcc      180

tcgtgggcca agggacggtt caccatctcg cgggacaact ccaagaacac tgtgtatctg      240

cagatgaaca gcctgagggc agaagatacc gccgtgtact actgcgcgag agatcgcttc      300

gtgggcgtgg acatctttga cccgtggggt caaggcaccc tggtcactgt ctcgagcgct      360

tctacaaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc      420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac      600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa      660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aagagcctct ccctgtctcc gggtaaa                                         1347


<210>  32
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11041 gH5 D54E (gH14) heavy chain (IgG4P)

<400>  32

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Asp Ile Glu Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Arg Phe Val Gly Val Asp Ile Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445     


<210>  33
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11041 gH5 D54E (gH14) heavy chain (IgG4P)

<400>  33
gaggtgcagc tcgtggaaag cggaggagga ctggtgcagc caggagggtc cttgcggctt       60

agctgtgccg tgtccggctt ctccctgtcc tcctacgcca tgatctgggt ccgccaagct      120

cctgggaagg gcctcgaatg gattggtatt atcgacatcg agggatcaac ctactacgcc      180

tcgtgggcca agggacggtt caccatctcg cgggacaact ccaagaacac tgtgtatctg      240

cagatgaaca gcctgagggc agaagatacc gccgtgtact actgcgcgag agatcgcttc      300

gtgggcgtgg acatctttga cccgtggggt caaggcaccc tggtcactgt ctcgagcgct      360

tctacaaagg gcccctccgt gttccctctg gccccttgct cccggtccac ctccgagtct      420

accgccgctc tgggctgcct ggtcaaggac tacttccccg agcccgtgac agtgtcctgg      480

aactctggcg ccctgacctc cggcgtgcac accttccctg ccgtgctgca gtcctccggc      540

ctgtactccc tgtcctccgt cgtgaccgtg ccctcctcca gcctgggcac caagacctac      600

acctgtaacg tggaccacaa gccctccaac accaaggtgg acaagcgggt ggaatctaag      660

tacggccctc cctgcccccc ctgccctgcc cctgaatttc tgggcggacc ttccgtgttc      720

ctgttccccc caaagcccaa ggacaccctg atgatctccc ggacccccga agtgacctgc      780

gtggtggtgg acgtgtccca ggaagatccc gaggtccagt tcaattggta cgtggacggc      840

gtggaagtgc acaatgccaa gaccaagccc agagaggaac agttcaactc cacctaccgg      900

gtggtgtccg tgctgaccgt gctgcaccag gactggctga acggcaaaga gtacaagtgc      960

aaggtgtcca acaagggcct gccctccagc atcgaaaaga ccatctccaa ggccaagggc     1020

cagccccgcg agccccaggt gtacaccctg ccccctagcc aggaagagat gaccaagaac     1080

caggtgtccc tgacctgtct ggtcaagggc ttctacccct ccgacattgc cgtggaatgg     1140

gagtccaacg gccagcccga gaacaactac aagaccaccc cccctgtgct ggacagcgac     1200

ggctccttct tcctgtactc tcggctgacc gtggacaagt cccggtggca ggaaggcaac     1260

gtcttctcct gctccgtgat gcacgaggcc ctgcacaacc actacaccca gaagtccctg     1320

tccctgagcc tgggcaag                                                   1338


<210>  34
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rabbit 11041 VL-region

<400>  34

Ala Val Val Leu Thr Gln Thr Ala Ser Pro Val Ser Ala Pro Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Asp Ile Tyr Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ala Cys Val Tyr Gly Asn Ser 
                85                  90                  95      


Ala Asp Ser Arg Tyr Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


<210>  35
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rabbit 11041 VL-region

<400>  35
gccgtcgtgc tgacccagac tgcatccccc gtgtctgcac ctgtgggagg cacagtcacc       60

atcaagtgcc aggccagtga ggacatttac accaatttag cctggtatca acagaaacca      120

ggacagcctc ccaagctcct gatctactgg gcatccactc tggcatctgg ggtcccatcg      180

cggttcaaag gcagtggatc tgggacagag ttcactctca ccatcagcga cctggagtgt      240

gccgatgctg ccacttacta ctgtcaagcc tgtgtttatg gcaatagtgc tgatagtcgg      300

tatactttcg gcggagggac cgaggtggtg gtcaaa                                336


<210>  36
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rabbit 11041 VH-region

<400>  36

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Ala 
            20                  25                  30          


Met Ile Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Asp Ile Asp Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Gly Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Arg 
                85                  90                  95      


Phe Val Gly Val Asp Ile Phe Asp Pro Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  37
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rabbit 11041 VH-region

<400>  37
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctggattctc cctcagtagc tatgcaatga tctgggtccg ccaggctcca      120

ggggaggggc tggaatggat cggaatcatt gatattgatg ggagcacata ctacgcgagc      180

tgggcgaaag gccgattcac catctccaga acctcgacca cggtggatct gaaaatcacc      240

agtccgacaa ccggggacac ggccacctat ttctgtgcca gagatcgttt tgttggtgtt      300

gatatttttg atccctgggg cccaggcacc ctggtcaccg tctcgagc                   348


<210>  38
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11041gL1 V-region

<400>  38

Ala Val Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Ile Tyr Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ala Cys Val Tyr Gly Asn Ser 
                85                  90                  95      


Ala Asp Ser Arg Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  39
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11041 gL1 C91S V-region (gL2)

<400>  39

Ala Val Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Ile Tyr Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ala Ser Val Tyr Gly Asn Ser 
                85                  90                  95      


Ala Asp Ser Arg Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  40
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11041 gL1 C91V V-region (gL3)

<400>  40

Ala Val Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Ile Tyr Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ala Val Val Tyr Gly Asn Ser 
                85                  90                  95      


Ala Asp Ser Arg Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  41
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11041gL6 V-region

<400>  41

Ala Val Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Ile Tyr Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ala Cys Val Tyr Gly Asn Ser 
                85                  90                  95      


Ala Asp Ser Arg Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  42
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11041gL7 V-region

<400>  42

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Ile Tyr Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ala Cys Val Tyr Gly Asn Ser 
                85                  90                  95      


Ala Asp Ser Arg Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  43
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11041 gL1 N95D V-region (gL8)

<400>  43

Ala Val Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Ile Tyr Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ala Cys Val Tyr Gly Asp Ser 
                85                  90                  95      


Ala Asp Ser Arg Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  44
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11041 gL1 S96A V-region (gL9)

<400>  44

Ala Val Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Ile Tyr Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ala Cys Val Tyr Gly Asn Ala 
                85                  90                  95      


Ala Asp Ser Arg Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  45
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11041 gL1 C91S S96A V-region (gL10)

<400>  45

Ala Val Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Ile Tyr Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ala Ser Val Tyr Gly Asn Ala 
                85                  90                  95      


Ala Asp Ser Arg Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  46
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11041 gL6 C91S V-region (gL11)

<400>  46

Ala Val Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Ile Tyr Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ala Ser Val Tyr Gly Asn Ser 
                85                  90                  95      


Ala Asp Ser Arg Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  47
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11041 gL7 C91S V-region (gL12)

<400>  47

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Ile Tyr Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ala Ser Val Tyr Gly Asn Ser 
                85                  90                  95      


Ala Asp Ser Arg Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  48
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11041 gL7 C91S S96A V-region (gL14)

<400>  48

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Ile Tyr Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ala Ser Val Tyr Gly Asn Ala 
                85                  90                  95      


Ala Asp Ser Arg Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  49
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11041gH1 V-region

<400>  49

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Asp Ile Asp Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Arg Phe Val Gly Val Asp Ile Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  50
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11041 gH1 G55A V-region (gH2)

<400>  50

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Asp Ile Asp Ala Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Arg Phe Val Gly Val Asp Ile Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  51
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11041 gH1 D54E V-region (gH3)

<400>  51

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Asp Ile Glu Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Arg Phe Val Gly Val Asp Ile Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  52
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11041 gH1 D107E V-region (gH4)

<400>  52

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Asp Ile Asp Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Arg Phe Val Gly Val Asp Ile Phe Glu Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  53
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11041gH5 V-region

<400>  53

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Asp Ile Asp Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Arg Phe Val Gly Val Asp Ile Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  54
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11041gH8 V-region

<400>  54

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Asp Ile Asp Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Arg Phe Val Gly Val Asp Ile Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  55
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11041gH9 V-region

<400>  55

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Asp Ile Asp Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Arg Phe Val Gly Val Asp Ile Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  56
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11041gH11 V-region

<400>  56

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ile Ile Asp Ile Asp Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Arg Phe Val Gly Val Asp Ile Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  57
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11041gH12 V-region

<400>  57

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Ile Ile Asp Ile Asp Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Arg Phe Val Gly Val Asp Ile Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  58
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11041 gH8 D54E V-region (gH15)

<400>  58

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Asp Ile Glu Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Arg Phe Val Gly Val Asp Ile Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  59
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11041 gH11 D54E V-region (gH17)

<400>  59

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ile Ile Asp Ile Glu Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Arg Phe Val Gly Val Asp Ile Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  60
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11041 gH12 D54E V-region (gH18)

<400>  60

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Ile Ile Asp Ile Glu Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Arg Phe Val Gly Val Asp Ile Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  61
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IGKV1D-13 IGKJ4 acceptor framework

<400>  61

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  62
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IGKV1D-13 IGKJ4 acceptor framework

<400>  62
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gggcattagc agtgctttag cctggtatca gcagaaacca      120

gggaaagctc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag tttaatagtt accctctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  63
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IGHV3-66 IGHJ4 acceptor framework

<400>  63

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  64
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IGHV3-66 IGHJ4 acceptor framework

<400>  64
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagcac atactacgca      180

gactccgtga agggcagatt caccatctcc agagacaatt ccaagaacac gctgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag atactttgac      300

tactggggcc aaggaaccct ggtcaccgtc tcctca                                336


<210>  65
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11070 CDRL1

<400>  65

Lys Ala Ser Lys Thr Ile Ser Lys Tyr Leu Ala 
1               5                   10      


<210>  66
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11070 CDRL2

<400>  66

Ser Gly Ser Thr Leu Gln Ser 
1               5           


<210>  67
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11070 CDRL3

<400>  67

Gln Gln His Asn Glu Tyr Pro Leu Thr 
1               5                   


<210>  68
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11070 CDRH1

<400>  68

Gly Phe Ser Leu Thr Ser Tyr Ser Val His 
1               5                   10  


<210>  69
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11070 CDRH2

<400>  69

Arg Met Trp Ser Asp Gly Asp Thr Ser Tyr Asn Thr Ala Phe Thr Ser 
1               5                   10                  15      


<210>  70
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11070 CDRH3

<400>  70

Ser Leu Asp Phe Tyr Tyr Asp Thr Thr Leu Ala Phe 
1               5                   10          


<210>  71
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11070 CDRH2 (not mutated)

<400>  71

Arg Met Trp Ser Asp Gly Asp Thr Ser Tyr Asn Ser Ala Phe Thr Ser 
1               5                   10                  15      


<210>  72
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11070gL7 V-region

<400>  72

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Lys Thr Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Asn Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Asn Glu Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  73
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11070gL7 V-region

<400>  73
gacattcaga tgactcagtc gccttcgtcc gtgagcgcca gcgtcggaga cagagtgaca       60

atcacctgta aagcgtccaa gaccatctcc aagtacctgg cttggtatca gcagaaaccg      120

gggaaggcca acaagttgct tatctactcc ggttctactc tccaatcggg agtgccaagc      180

cggttttccg ggtccggatc aggcaccgac ttcaccctca ccatctcatc cctgcaaccg      240

gaggatttcg ccacgtacta ctgccagcag cacaacgaat accccctgac cttcggccaa      300

ggaactaagc tggaaattaa g                                                321


<210>  74
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11070gH16 V-region

<400>  74

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Ser Val His Trp Val Arg Gln His Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Met Trp Ser Asp Gly Asp Thr Ser Tyr Asn Thr Ala Phe Thr 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Leu Asp Phe Tyr Tyr Asp Thr Thr Leu Ala Phe Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  75
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11070gH16 V-region

<400>  75
gaggtgcagc tgcaagaatc cggtcctggc ctcgtgaagc cgtcgcagac cttgagcctg       60

acctgtactg tgtccggatt cagcctcaca tcctactcgg tgcactgggt cagacagcat      120

cccggaaaag gcctggaatg gattgggagg atgtggtctg atggagacac ctcctacaac      180

acggcgttca ccagccggct gaccatctcc cgcgacacct ccaagaacca agtgtcgctt      240

aagctgtcct cagtcactgc cgccgatacc gcagtgtatt actgcgctcg gtcactggac      300

ttttactacg acaccaccct ggccttctgg ggacagggga ctactgtgac tgtctcgagc      360


<210>  76
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11070gL7 Light chain

<400>  76

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Lys Thr Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Asn Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Asn Glu Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  77
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11070gL7 Light chain

<400>  77
gacattcaga tgactcagtc gccttcgtcc gtgagcgcca gcgtcggaga cagagtgaca       60

atcacctgta aagcgtccaa gaccatctcc aagtacctgg cttggtatca gcagaaaccg      120

gggaaggcca acaagttgct tatctactcc ggttctactc tccaatcggg agtgccaagc      180

cggttttccg ggtccggatc aggcaccgac ttcaccctca ccatctcatc cctgcaaccg      240

gaggatttcg ccacgtacta ctgccagcag cacaacgaat accccctgac cttcggccaa      300

ggaactaagc tggaaattaa gcgtacggtg gccgctccct ccgtgttcat cttcccaccc      360

tccgacgagc agctgaagtc cggcaccgcc tccgtcgtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caactcccag      480

gaatccgtca ccgagcagga ctccaaggac agcacctact ccctgtcctc caccctgacc      540

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtccagcc ccgtgaccaa gtccttcaac cggggcgagt gc                         642


<210>  78
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11070gH16 Fab Heavy chain

<400>  78

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Ser Val His Trp Val Arg Gln His Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Met Trp Ser Asp Gly Asp Thr Ser Tyr Asn Thr Ala Phe Thr 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Leu Asp Phe Tyr Tyr Asp Thr Thr Leu Ala Phe Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220             


<210>  79
<211>  669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11070gH16 Fab Heavy chain

<400>  79
gaggtgcagc tgcaagaatc cggtcctggc ctcgtgaagc cgtcgcagac cttgagcctg       60

acctgtactg tgtccggatt cagcctcaca tcctactcgg tgcactgggt cagacagcat      120

cccggaaaag gcctggaatg gattgggagg atgtggtctg atggagacac ctcctacaac      180

acggcgttca ccagccggct gaccatctcc cgcgacacct ccaagaacca agtgtcgctt      240

aagctgtcct cagtcactgc cgccgatacc gcagtgtatt actgcgctcg gtcactggac      300

ttttactacg acaccaccct ggccttctgg ggacagggga ctactgtgac tgtctcgagc      360

gcgtccacaa agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccagt gacggtgtcg      480

tggaactcag gtgccctgac cagcggcgtt cacaccttcc cggctgtcct acagtcttca      540

ggactctact ccctgagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tcgataagaa agttgagccc      660

aaatcttgt                                                              669


<210>  80
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11070gH16 IgG1 Heavy chain

<400>  80

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Ser Val His Trp Val Arg Gln His Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Met Trp Ser Asp Gly Asp Thr Ser Tyr Asn Thr Ala Phe Thr 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Leu Asp Phe Tyr Tyr Asp Thr Thr Leu Ala Phe Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  81
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11070gH16 IgG1 Heavy chain

<400>  81
gaggtgcagc tgcaagaatc cggtcctggc ctcgtgaagc cgtcgcagac cttgagcctg       60

acctgtactg tgtccggatt cagcctcaca tcctactcgg tgcactgggt cagacagcat      120

cccggaaaag gcctggaatg gattgggagg atgtggtctg atggagacac ctcctacaac      180

acggcgttca ccagccggct gaccatctcc cgcgacacct ccaagaacca agtgtcgctt      240

aagctgtcct cagtcactgc cgccgatacc gcagtgtatt actgcgctcg gtcactggac      300

ttttactacg acaccaccct ggccttctgg ggacagggga ctactgtgac tgtctcgagc      360

gcttctacaa agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1080

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210>  82
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11070gH16 IgG4P Heavy chain

<400>  82

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Ser Val His Trp Val Arg Gln His Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Met Trp Ser Asp Gly Asp Thr Ser Tyr Asn Thr Ala Phe Thr 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Leu Asp Phe Tyr Tyr Asp Thr Thr Leu Ala Phe Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  83
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11070gH16 IgG4P Heavy chain

<400>  83
gaggtgcagc tgcaagaatc cggtcctggc ctcgtgaagc cgtcgcagac cttgagcctg       60

acctgtactg tgtccggatt cagcctcaca tcctactcgg tgcactgggt cagacagcat      120

cccggaaaag gcctggaatg gattgggagg atgtggtctg atggagacac ctcctacaac      180

acggcgttca ccagccggct gaccatctcc cgcgacacct ccaagaacca agtgtcgctt      240

aagctgtcct cagtcactgc cgccgatacc gcagtgtatt actgcgctcg gtcactggac      300

ttttactacg acaccaccct ggccttctgg ggacagggga ctactgtgac tgtctcgagc      360

gcttctacaa agggcccctc cgtgttccct ctggcccctt gctcccggtc cacctccgag      420

tctaccgccg ctctgggctg cctggtcaag gactacttcc ccgagcccgt gacagtgtcc      480

tggaactctg gcgccctgac ctccggcgtg cacaccttcc ctgccgtgct gcagtcctcc      540

ggcctgtact ccctgtcctc cgtcgtgacc gtgccctcct ccagcctggg caccaagacc      600

tacacctgta acgtggacca caagccctcc aacaccaagg tggacaagcg ggtggaatct      660

aagtacggcc ctccctgccc cccctgccct gcccctgaat ttctgggcgg accttccgtg      720

ttcctgttcc ccccaaagcc caaggacacc ctgatgatct cccggacccc cgaagtgacc      780

tgcgtggtgg tggacgtgtc ccaggaagat cccgaggtcc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaatgc caagaccaag cccagagagg aacagttcaa ctccacctac      900

cgggtggtgt ccgtgctgac cgtgctgcac caggactggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccctcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagcccc gcgagcccca ggtgtacacc ctgcccccta gccaggaaga gatgaccaag     1080

aaccaggtgt ccctgacctg tctggtcaag ggcttctacc cctccgacat tgccgtggaa     1140

tgggagtcca acggccagcc cgagaacaac tacaagacca ccccccctgt gctggacagc     1200

gacggctcct tcttcctgta ctctcggctg accgtggaca agtcccggtg gcaggaaggc     1260

aacgtcttct cctgctccgt gatgcacgag gccctgcaca accactacac ccagaagtcc     1320

ctgtccctga gcctgggcaa g                                               1341


<210>  84
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat Ab 11070 VL-region

<400>  84

Asp Ile Val Met Thr Gln Thr Pro Ser Asn Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Asn Cys Lys Ala Ser Lys Thr Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Asn Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Thr Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Ser Thr Asp Phe Thr Leu Thr Ile Arg Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Leu Tyr Tyr Cys Gln Gln His Asn Glu Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  85
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat Ab 11070 VL-region

<400>  85
gatattgtga tgacacagac tccatctaat cttgctgcct ctcctggaga aagtgtttcc       60

atcaattgca aggcaagtaa gaccattagc aagtatttag cctggtatca acagaaacct      120

gggaaagcaa ataagcttct tatctattct gggtcaactt tgcaatctgg aactccatcg      180

aggttcagtg gcagtggatc tagtacagat ttcactctca ccatcagaaa cctggagcct      240

gaagattttg gactctatta ctgtcaacag cataatgaat acccgctcac gttcggttct      300

gggaccaagt tggaaataaa a                                                321


<210>  86
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat Ab 11070 VH-region

<400>  86

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Pro Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Ser Val His Trp Val Arg Gln His Ser Gly Lys Ser Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Met Trp Ser Asp Gly Asp Thr Ser Tyr Asn Ser Ala Phe Thr 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Gly Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Leu Asp Phe Tyr Tyr Asp Thr Thr Leu Ala Phe Trp Gly Pro 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  87
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat Ab 11070 VH-region

<400>  87
gaggtgcagc tgcaggagtc aggacctggg ctggtgcagc cctcacagac cctgtccccc       60

acctgcactg tctctgggtt ctcactaact agttacagtg tacactgggt tcgccagcat      120

tcaggaaaga gtctggaatg gatgggaaga atgtggagtg atggagacac atcatataat      180

tcagcgttca catcccgatt gagcatcact agggacacct ccaagagcca agttttctta      240

aaaatgaaca gtctgcaaac tgaagacaca ggcacttact actgtgccag aagtctcgat      300

ttttactatg atactactct tgccttctgg ggcccaggaa ccacggtcac cgtctcgagt      360


<210>  88
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11070gL1 V-region

<400>  88

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Lys Thr Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Asn Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Thr Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Ser Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Asn Glu Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  89
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11070gH1 V-region

<400>  89

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Ser Val His Trp Val Arg Gln His Ser Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Met Trp Ser Asp Gly Asp Thr Ser Tyr Asn Ser Ala Phe Thr 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Leu Asp Phe Tyr Tyr Asp Thr Thr Leu Ala Phe Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  90
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11070gH13 V-region (gH1 S61T)

<400>  90

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Ser Val His Trp Val Arg Gln His Ser Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Met Trp Ser Asp Gly Asp Thr Ser Tyr Asn Thr Ala Phe Thr 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Leu Asp Phe Tyr Tyr Asp Thr Thr Leu Ala Phe Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  91
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IGKV1-12 IGKJ2 acceptor framework

<400>  91

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  92
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IGKV1-12 IGKJ2 acceptor framework

<400>  92
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttacta ttgtcaacag gctaacagtt tcccttacac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210>  93
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IGHV4-31 IGHJ6 acceptor framework

<400>  93

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  94
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IGHV4-31 IGHJ6 acceptor framework

<400>  94
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agtggtggtt actactggag ctggatccgc      120

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcacctac      180

tacaacccgt ccctcaagag tcgagttacc atatcagtag acacgtctaa gaaccagttc      240

tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagatac      300

tactactact acggtatgga cgtctggggg caagggacca cggtcaccgt ctcctca         357


<210>  95
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 72-84

<400>  95

Val Arg Leu Ile Gly Glu Lys Leu Phe His Gly Val Ser 
1               5                   10              


<210>  96
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL22 peptide 72-85

<400>  96

Val Arg Leu Ile Gly Glu Lys Leu Phe His Gly Val Ser Met 
1               5                   10                  


<210>  97
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL22 peptide 75-84

<400>  97

Ile Gly Glu Lys Leu Phe His Gly Val Ser 
1               5                   10  


<210>  98
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL22 peptide 75-85

<400>  98

Ile Gly Glu Lys Leu Phe His Gly Val Ser Met 
1               5                   10      


<210>  99
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL22 peptide 76-84

<400>  99

Gly Glu Lys Leu Phe His Gly Val Ser 
1               5                   


<210>  100
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL22 peptide 80-85

<400>  100

Phe His Gly Val Ser Met 
1               5       


<210>  101
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL22 peptide 126-139

<400>  101

Ser Asn Arg Leu Ser Thr Cys His Ile Glu Gly Asp Asp Leu 
1               5                   10                  


<210>  102
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL22 peptide 101-111

<400>  102

Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe 
1               5                   10      


<210>  103
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL22 peptide 103-115

<400>  103

Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro Tyr Met 
1               5                   10              


<210>  104
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL22 peptide 103-117

<400>  104

Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro Tyr Met Gln Glu 
1               5                   10                  15  


<210>  105
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL22 peptide 43-58

<400>  105

Asp Lys Ser Asn Phe Gln Gln Pro Tyr Ile Thr Asn Arg Thr Phe Met 
1               5                   10                  15      


<210>  106
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL22 peptide 105-117

<400>  106

Phe Pro Gln Ser Asp Arg Phe Gln Pro Tyr Met Gln Glu 
1               5                   10              


