                         SEQUENCE LISTING

<110>   ҩҵ޹˾
 
<120>  MSLNĿ弰;

<130>  SR0388-PCT/L-TN-OF211174S/P

<160>  142   

<170>  PatentIn version 3.5

<210>  1
<211>  122
<212>  PRT
<213>  ˹
<400>  1
Gln Glu Gln Leu Glu Glu Ser Gly Gly Asp Leu Val Gln Pro Glu Gly 
1               5                   10                  15      
Ser Leu Thr Leu Thr Cys Lys Ala Ser Gly Leu Asp Phe Ser Ser Ser 
            20                  25                  30          
Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Ile Gly Cys Arg His Thr Phe Thr Ala Asn Thr Trp Ser Ala Ser Trp 
    50                  55                  60                  
Val Asn Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser Leu Gly Thr Val 
65                  70                  75                  80  
Asp Leu Lys Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      
Cys Ala Arg Asp Glu Ser Asn Asn Asp Gly Trp Asp Phe Lys Leu Trp 
            100                 105                 110         
Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         

<210>  2
<211>  109
<212>  PRT
<213>  ˹
<400>  2
Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      
Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Gln Ala Ser Thr Leu Ala Pro Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Val Glu Cys 
65                  70                  75                  80  
Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Thr Ser Ser Asn 
                85                  90                  95      
Val Glu Asn Val Phe Gly Gly Gly Thr Gly Val Val Val 
            100                 105                 

<210>  3
<211>  123
<212>  PRT
<213>  ˹
<400>  3
Gln Gln Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Glu Gly 
1               5                   10                  15      
Ser Leu Thr Leu Thr Cys Lys Ala Ser Gly Phe Asp Leu Gly Phe Tyr 
            20                  25                  30          
Phe Tyr Ala Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Ile Ala Cys Ile Tyr Thr Ala Gly Ser Gly Ser Thr Tyr Tyr Ala Ser 
    50                  55                  60                  
Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Ala Ser Ser Thr Thr Val 
65                  70                  75                  80  
Thr Leu Gln Met Thr Ser Leu Ala Ala Ala Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      
Cys Ala Arg Ser Thr Ala Asn Thr Arg Ser Thr Tyr Tyr Leu Asn Leu 
            100                 105                 110         
Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210>  4
<211>  110
<212>  PRT
<213>  ˹
<400>  4
Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 
1               5                   10                  15      
Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Arg Ile Ser Ser Tyr 
            20                  25                  30          
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile 
        35                  40                  45              
Phe Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  
Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Ala Tyr Phe Asp Ser 
                85                  90                  95      
Asn Asn Trp His Ala Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 110 

<210>  5
<211>  119
<212>  PRT
<213>  ˹
<400>  5
Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Ala 
1               5                   10                  15      
Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Ile Asp Phe Ser Arg Tyr 
            20                  25                  30          
Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Ile 
        35                  40                  45              
Ala Cys Ile Tyr Ile Gly Gly Ser Gly Ser Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  
Ala Lys Gly Arg Phe Thr Ile Ser Lys Ala Ser Ser Thr Thr Val Thr 
65                  70                  75                  80  
Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Gly Thr Asn Leu Asn Tyr Ile Phe Arg Leu Trp Gly Pro Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser 
        115                 

<210>  6
<211>  109
<212>  PRT
<213>  ˹
<400>  6
Asp Val Val Met Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      
Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Asn Asn Gly 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Ser Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  
Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Ile Trp Asp Gly Asn Ser 
                85                  90                  95      
Tyr Val Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 

<210>  7
<211>  246
<212>  PRT
<213>  ˹
<400>  7
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 
            20                  25                  30          
Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              
Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Glu Gly Lys Asn Gly Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         
Thr Met Val Thr Val Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             
Gly Ser Gly Gly Gly Gly Ser Arg His Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 
Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     
Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
            180                 185                 190         
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             
Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 
Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 
Ile Lys Gly Gln Ala Gly 
                245     

<210>  8
<211>  248
<212>  PRT
<213>  ˹
<400>  8
Gln Gln Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Glu Gly 
1               5                   10                  15      
Ser Leu Thr Leu Thr Cys Lys Ala Ser Gly Phe Asp Leu Gly Phe Tyr 
            20                  25                  30          
Phe Tyr Ala Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Ile Ala Cys Ile Tyr Thr Ala Gly Ser Gly Ser Thr Tyr Tyr Ala Ser 
    50                  55                  60                  
Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Ala Ser Ser Thr Thr Val 
65                  70                  75                  80  
Thr Leu Gln Met Thr Ser Leu Ala Ala Ala Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      
Cys Ala Arg Ser Thr Ala Asn Thr Arg Ser Thr Tyr Tyr Leu Asn Leu 
            100                 105                 110         
Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln 
    130                 135                 140                 
Thr Pro Ala Ser Val Ser Glu Pro Val Gly Gly Thr Val Thr Ile Lys 
145                 150                 155                 160 
Cys Gln Ala Ser Gln Arg Ile Ser Ser Tyr Leu Ser Trp Tyr Gln Gln 
                165                 170                 175     
Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile Phe Gly Ala Ser Thr Leu 
            180                 185                 190         
Ala Ser Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Glu 
        195                 200                 205             
Tyr Thr Leu Thr Ile Ser Asp Leu Glu Cys Ala Asp Ala Ala Thr Tyr 
    210                 215                 220                 
Tyr Cys Gln Ser Tyr Ala Tyr Phe Asp Ser Asn Asn Trp His Ala Phe 
225                 230                 235                 240 
Gly Gly Gly Thr Glu Val Val Val 
                245             

<210>  9
<211>  449
<212>  PRT
<213>  ˹
<400>  9
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          
Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              
Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Ser Gly 
            100                 105                 110         
Thr Pro Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             
Lys 
    

<210>  10
<211>  213
<212>  PRT
<213>  ˹
<400>  10
Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu 
65                  70                  75                  80  
Asp Asp Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Lys His Pro Leu Thr 
                85                  90                  95      
Phe Gly Ser Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             
Asn Arg Gly Glu Cys 
    210             

<210>  11
<211>  232
<212>  PRT
<213>  Homo sapiens
<400>  11
Glu Pro Lys Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 
Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         

<210>  12
<211>  330
<212>  PRT
<213>  Homo sapiens
<400>  12
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 

<210>  13
<211>  107
<212>  PRT
<213>  Homo sapiens
<400>  13
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         

<210>  14
<211>  323
<212>  PRT
<213>  Oryctolagus cuniculus
<400>  14
Gly Gln Pro Lys Ala Pro Ser Val Phe Pro Leu Ala Pro Cys Cys Gly 
1               5                   10                  15      
Asp Thr Pro Ser Ser Thr Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          
Leu Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Thr Leu Thr Asn 
        35                  40                  45              
Gly Val Arg Thr Phe Pro Ser Val Arg Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Ser Val Thr Ser Ser Ser Gln Pro Val Thr Cys 
65                  70                  75                  80  
Asn Val Ala His Pro Ala Thr Asn Thr Lys Val Asp Lys Thr Val Ala 
                85                  90                  95      
Pro Ser Thr Cys Ser Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu Gly 
            100                 105                 110         
Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        115                 120                 125             
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
    130                 135                 140                 
Asp Asp Pro Glu Val Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln Val 
145                 150                 155                 160 
Arg Thr Ala Arg Pro Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr Ile 
                165                 170                 175     
Arg Val Val Ser Thr Leu Pro Ile Ala His Gln Asp Trp Leu Arg Gly 
            180                 185                 190         
Lys Glu Phe Lys Cys Lys Val His Asn Lys Ala Leu Pro Ala Pro Ile 
        195                 200                 205             
Glu Lys Thr Ile Ser Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys Val 
    210                 215                 220                 
Tyr Thr Met Gly Pro Pro Arg Glu Glu Leu Ser Ser Arg Ser Val Ser 
225                 230                 235                 240 
Leu Thr Cys Met Ile Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu 
                245                 250                 255     
Trp Glu Lys Asn Gly Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro Ala 
            260                 265                 270         
Val Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val 
        275                 280                 285             
Pro Thr Ser Glu Trp Gln Arg Gly Asp Val Phe Thr Cys Ser Val Met 
    290                 295                 300                 
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Ile Ser Arg Ser 
305                 310                 315                 320 
Pro Gly Lys 
            

<210>  15
<211>  104
<212>  PRT
<213>  Oryctolagus cuniculus
<400>  15
Gly Asp Pro Val Ala Pro Thr Val Leu Ile Phe Pro Pro Ala Ala Asp 
1               5                   10                  15      
Gln Val Ala Thr Gly Thr Val Thr Ile Val Cys Val Ala Asn Lys Tyr 
            20                  25                  30          
Phe Pro Asp Val Thr Val Thr Trp Glu Val Asp Gly Thr Thr Gln Thr 
        35                  40                  45              
Thr Gly Ile Glu Asn Ser Lys Thr Pro Gln Asn Ser Ala Asp Cys Thr 
    50                  55                  60                  
Tyr Asn Leu Ser Ser Thr Leu Thr Leu Thr Ser Thr Gln Tyr Asn Ser 
65                  70                  75                  80  
His Lys Glu Tyr Thr Cys Lys Val Thr Gln Gly Thr Thr Ser Val Val 
                85                  90                  95      
Gln Ser Phe Asn Arg Gly Asp Cys 
            100                 

<210>  16
<211>  622
<212>  PRT
<213>  Homo sapiens
<400>  16
Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro 
1               5                   10                  15      
Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 
            20                  25                  30          
Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu 
        35                  40                  45              
Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg 
    50                  55                  60                  
Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu 
65                  70                  75                  80  
Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu 
                85                  90                  95      
Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro 
            100                 105                 110         
Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro 
        115                 120                 125             
Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile 
    130                 135                 140                 
Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln 
145                 150                 155                 160 
Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu 
                165                 170                 175     
Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu 
            180                 185                 190         
Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu 
        195                 200                 205             
Val Ser Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg 
    210                 215                 220                 
Ala Ala Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp 
225                 230                 235                 240 
Ser Val Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly 
                245                 250                 255     
Gln Pro Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg 
            260                 265                 270         
Gln Arg Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile 
        275                 280                 285             
Leu Arg Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser 
    290                 295                 300                 
Gly Lys Lys Ala Pro Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys 
305                 310                 315                 320 
Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met 
                325                 330                 335     
Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu 
            340                 345                 350         
Lys His Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val 
        355                 360                 365             
Ile Gln His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile 
    370                 375                 380                 
Arg Lys Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu 
385                 390                 395                 400 
Val Asn Lys Gly His Glu Met Ser Pro Gln Val Ala Thr Leu Ile Asp 
                405                 410                 415     
Arg Phe Val Lys Gly Arg Gly Gln Leu Asp Lys Asp Thr Leu Asp Thr 
            420                 425                 430         
Leu Thr Ala Phe Tyr Pro Gly Tyr Leu Cys Ser Leu Ser Pro Glu Glu 
        435                 440                 445             
Leu Ser Ser Val Pro Pro Ser Ser Ile Trp Ala Val Arg Pro Gln Asp 
    450                 455                 460                 
Leu Asp Thr Cys Asp Pro Arg Gln Leu Asp Val Leu Tyr Pro Lys Ala 
465                 470                 475                 480 
Arg Leu Ala Phe Gln Asn Met Asn Gly Ser Glu Tyr Phe Val Lys Ile 
                485                 490                 495     
Gln Ser Phe Leu Gly Gly Ala Pro Thr Glu Asp Leu Lys Ala Leu Ser 
            500                 505                 510         
Gln Gln Asn Val Ser Met Asp Leu Ala Thr Phe Met Lys Leu Arg Thr 
        515                 520                 525             
Asp Ala Val Leu Pro Leu Thr Val Ala Glu Val Gln Lys Leu Leu Gly 
    530                 535                 540                 
Pro His Val Glu Gly Leu Lys Ala Glu Glu Arg His Arg Pro Val Arg 
545                 550                 555                 560 
Asp Trp Ile Leu Arg Gln Arg Gln Asp Asp Leu Asp Thr Leu Gly Leu 
                565                 570                 575     
Gly Leu Gln Gly Gly Ile Pro Asn Gly Tyr Leu Val Leu Asp Leu Ser 
            580                 585                 590         
Met Gln Glu Ala Leu Ser Gly Thr Pro Cys Leu Leu Gly Pro Gly Pro 
        595                 600                 605             
Val Leu Thr Val Leu Ala Leu Leu Leu Ala Ser Thr Leu Ala 
    610                 615                 620         

<210>  17
<211>  627
<212>  PRT
<213>  Macaca fascicularis
<400>  17
Met Ala Leu Pro Met Ala Arg Pro Leu Ser Gly Ser Cys Gly Thr Pro 
1               5                   10                  15      
Ala Val Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 
            20                  25                  30          
Pro Ser Arg Val Leu Ala Gly Glu Thr Arg Gln Ala Leu Cys Pro Gln 
        35                  40                  45              
Glu Ala Ala Pro Leu Asp Gly Ile Leu Thr Asn Ala Pro Asp Ile Ala 
    50                  55                  60                  
Ser Leu Ser Pro Arg Gln Leu Leu Gly Phe Thr Cys Val Glu Val Ser 
65                  70                  75                  80  
Gly Leu Ser Thr Glu Leu Val Gln Glu Leu Ala Val Ala Leu Gly Gln 
                85                  90                  95      
Lys Asn Val Lys Leu Ser Ala Glu Gln Leu Arg Cys Leu Ala His Arg 
            100                 105                 110         
Leu Ser Glu Pro Pro Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu 
        115                 120                 125             
Leu Phe Leu Asn Pro Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr His 
    130                 135                 140                 
Phe Phe Ser Arg Val Ala Lys Ala Asn Val Asp Leu Leu Pro Arg Gly 
145                 150                 155                 160 
Ala Pro Glu Arg Gln Arg Leu Leu Pro Ala Ala Leu Thr Cys Trp Gly 
                165                 170                 175     
Val Arg Gly Ser Leu Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly 
            180                 185                 190         
Leu Ala Cys Asp Leu Pro Gly Cys Phe Val Ala Glu Ser Ala Glu Val 
        195                 200                 205             
Val Leu Pro Arg Leu Val Arg Cys Leu Gly Pro Leu Asp Gln Asp Gln 
    210                 215                 220                 
Gln Glu Ala Ala Arg Ala Ala Leu Gln Arg Gly Gly Pro Pro Tyr Gly 
225                 230                 235                 240 
Pro Pro Ser Thr Trp Ser Ile Ser Thr Leu Asp Asp Leu Gln Ser Leu 
                245                 250                 255     
Leu Pro Val Leu Gly Gln Pro Val Ile His Ser Ile Pro Lys Gly Ile 
            260                 265                 270         
Leu Ala Ala Trp Arg Gln Arg Ser Ser Arg Asp Pro Ser Trp Gln Gln 
        275                 280                 285             
Pro Glu Gln Thr Val Leu Arg Pro Arg Phe Arg Arg Asp Val Glu Arg 
    290                 295                 300                 
Thr Thr Cys Pro Pro Glu Lys Glu Val His Glu Ile Asp Glu Ser Leu 
305                 310                 315                 320 
Ile Phe Tyr Lys Lys Arg Glu Leu Glu Ala Cys Val Asp Ala Ala Leu 
                325                 330                 335     
Leu Ala Ala Gln Met Asp Arg Val Asp Ala Ile Pro Phe Thr Tyr Glu 
            340                 345                 350         
Gln Leu Asp Val Leu Lys His Lys Leu Asp Glu Leu Tyr Pro Gln Gly 
        355                 360                 365             
Tyr Pro Glu Ser Val Ile Arg His Leu Gly His Leu Phe Leu Lys Met 
    370                 375                 380                 
Ser Pro Glu Asp Ile Arg Lys Trp Asn Val Thr Ser Leu Glu Thr Leu 
385                 390                 395                 400 
Lys Ala Leu Leu Lys Val Ser Lys Gly His Glu Met Ser Ala Gln Val 
                405                 410                 415     
Ala Thr Leu Ile Asp Arg Val Val Val Gly Arg Gly Gln Leu Asp Lys 
            420                 425                 430         
Asp Thr Val Asp Thr Leu Thr Ala Phe Cys Pro Gly Cys Leu Cys Ser 
        435                 440                 445             
Leu Ser Pro Glu Arg Leu Ser Ser Val Pro Pro Ser Val Ile Gly Ala 
    450                 455                 460                 
Val Arg Pro Gln Asp Leu Asp Thr Cys Gly Pro Arg Gln Leu Asp Val 
465                 470                 475                 480 
Leu Tyr Pro Lys Ala Arg Leu Ala Phe Gln Asn Met Ser Gly Ser Glu 
                485                 490                 495     
Tyr Phe Val Lys Ile Arg Pro Phe Leu Gly Gly Ala Pro Thr Glu Asp 
            500                 505                 510         
Val Lys Ala Leu Ser Gln Gln Asn Val Ser Met Asp Leu Ala Thr Phe 
        515                 520                 525             
Met Lys Leu Arg Arg Glu Ala Val Leu Pro Leu Thr Val Ala Glu Val 
    530                 535                 540                 
Gln Lys Leu Leu Gly Pro His Val Glu Gly Leu Lys Val Glu Glu Gln 
545                 550                 555                 560 
His Ser Pro Val Arg Asp Trp Ile Leu Lys Gln Arg Gln Asp Asp Leu 
                565                 570                 575     
Asp Thr Leu Gly Leu Gly Leu Gln Gly Gly Ile Pro Asn Gly Tyr Leu 
            580                 585                 590         
Ile Leu Asp Leu Ser Val Arg Glu Ala Leu Ser Gly Thr Pro Cys Leu 
        595                 600                 605             
Leu Gly Pro Gly Pro Val Leu Thr Val Leu Ala Leu Leu Leu Ala Ser 
    610                 615                 620                 
Thr Leu Ala 
625         

<210>  18
<211>  18
<212>  DNA
<213>  ˹
<400>  18
cttggtggtc ctggctgc                                                     18

<210>  19
<211>  23
<212>  DNA
<213>  ˹
<400>  19
ggtacgtgct gttgaactgt tcc                                               23

<210>  20
<211>  47
<212>  DNA
<213>  ˹
<400>  20
catgccatga ctgtggccca ggcggcccag ktgcagctcg tggagtc                     47

<210>  21
<211>  51
<212>  DNA
<213>  ˹
<400>  21
catgccatga ctcgcggccg gcctggccat gggggtcttc gctgtggtgc g                51

<210>  22
<211>  52
<212>  DNA
<213>  ˹
<400>  22
catgccatga ctcgcggccg gcctggccgt cttgtggttt tggtgtcttg gg               52

<210>  23
<211>  111
<212>  PRT
<213>  ˹
<400>  23
Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Ser Thr Ser Met Ser Tyr 
            20                  25                  30          
Gly Ala Lys Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              
Ala Ser Val Tyr Arg Asp Gly Thr Thr Gly Tyr Asp Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Leu Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Leu Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      
Ala Leu Asn Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 110     

<210>  24
<211>  115
<212>  PRT
<213>  ˹
<400>  24
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Gly Arg Ile 
            20                  25                  30          
Val Met Arg Trp Tyr Arg Gln Ala Gln Gly Lys Gln Arg Glu Trp Val 
        35                  40                  45              
Ala Ser Ile Tyr Asp Ser Gly Ser Thr Ser Tyr Ser Asp Pro Val Gln 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Ala Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      
Leu Gly Thr Ala Leu Ser Ser Tyr Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210>  25
<211>  127
<212>  PRT
<213>  ˹
<400>  25
Glu Val Gln Val Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Ala 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ser Ser Gly Arg Thr Ile Ser Pro Ile 
            20                  25                  30          
Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              
Ala Gly Leu Thr Trp Thr Gly Arg Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asp Ser Leu Lys Phe Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      
Ala Gly Asp Asn Pro Asp Arg Arg Gly Ser Ser Trp Ser Ser Ser Ser 
            100                 105                 110         
Val Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         

<210>  26
<211>  116
<212>  PRT
<213>  ˹
<400>  26
Glu Val Gln Val Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Gly Val Ser Gly Ser Ile Leu Ala Leu Asn 
            20                  25                  30          
Thr Met Arg Trp Tyr Arg Gln Thr Pro Gly Asn Gln Arg Glu Trp Val 
        35                  40                  45              
Ala Ser Ile Tyr Ser Ser Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Ile Ile Ser Arg Asp Ser Ala Lys Asn Met Met Ser 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Asn Val Gln Thr Pro Leu Asn Val Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210>  27
<211>  117
<212>  PRT
<213>  ˹
<400>  27
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser Ser Tyr 
            20                  25                  30          
Pro Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      
Thr Arg Ser Pro Arg Val Pro Asn Asp Ser Trp Gly Gln Gly Thr Gln 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210>  28
<211>  115
<212>  PRT
<213>  ˹
<400>  28
Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser His Arg Leu Ser Cys Ala Val Ser Val Ser Thr Phe Thr Arg Tyr 
            20                  25                  30          
Ala Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Leu 
        35                  40                  45              
Thr Ser Ile Tyr Ser Asp Gly Ser Ser Ala Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Asp Arg Phe Thr Ile Ser Leu Asp Asn Ala Lys Asn Met Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      
Ala Asn Val Asp Ser Lys Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         
Val Ala Ser 
        115 

<210>  29
<211>  121
<212>  PRT
<213>  ˹
<400>  29
Glu Val Gln Val Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Ser Gly Asn 
            20                  25                  30          
Tyr Gly Gly Trp Phe Arg Gln Ala Pro Gly Glu Gln Arg Glu Leu Val 
        35                  40                  45              
Ala Ser Met Ser Ser Ala Leu Gly Thr Lys Tyr Ala Asp Pro Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Thr Asp Thr Ala Lys Asn Thr Val Asp Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Gly Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      
Ala Arg Val Arg Leu Ser Arg Gly Gly Trp Gly Ser Glu Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     

<210>  30
<211>  119
<212>  PRT
<213>  ˹
<400>  30
Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val Asn Ser Ile Thr 
            20                  25                  30          
Ala Met Gly Trp Tyr Arg Gln Gly Pro Gly Asn Glu Arg Glu Leu Val 
        35                  40                  45              
Ala Val Ile Thr Asp Arg Gly Arg Ala Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Ala Ile Ser Met Asp Asn Asp Lys His Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      
Ala His Arg Arg Thr Trp Pro His Pro Gly Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Gln Val Thr Val Ser Ser 
        115                 

<210>  31
<211>  116
<212>  PRT
<213>  ˹
<400>  31
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Gly Asn 
            20                  25                  30          
Ala Val Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Ala Val 
        35                  40                  45              
Ala Val Ile Thr Arg Asp Gly Asp Thr Lys Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Tyr Asn Ala Lys Asn Ile Ala Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      
Thr Ala Arg Gly Ala Ala Val Asp Ser Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210>  32
<211>  122
<212>  PRT
<213>  ˹
<400>  32
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ala Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Ser Ser 
            20                  25                  30          
Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Asn Arg Ile Gly Gly His Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ser Ser Arg Ile Tyr Ser His Ser Ala Arg Asp Tyr Asp Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         

<210>  33
<211>  116
<212>  PRT
<213>  ˹
<400>  33
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Glu Ser Gly Phe Ser Ala Asn 
            20                  25                  30          
Tyr Met Gly Trp Tyr Arg Gln Glu Ala Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              
Val Ala Thr Ile Asn Arg Phe Gly Ser Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      
Arg Ile Met Arg Pro Gly Asn Trp Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210>  34
<211>  122
<212>  PRT
<213>  ˹
<400>  34
Glu Val Gln Val Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Gly Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Ser Ser 
            20                  25                  30          
Ser Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Thr Met Asn Arg Ile Gly Gly His Thr Phe Tyr Ala Asp Pro Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Ala Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Ala Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ser Ser Arg Ile Tyr Ser His Ser Pro Arg Asp Tyr Asp Tyr Trp 
            100                 105                 110         
Ser Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         

<210>  35
<211>  5
<212>  PRT
<213>  ˹
<400>  35
Ser Tyr Gly Ala Lys 
1               5   


<210>  36
<211>  16
<212>  PRT
<213>  ˹
<400>  36
Ser Val Tyr Arg Asp Gly Thr Thr Gly Tyr Asp Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  37
<211>  3
<212>  PRT
<213>  ˹
<400>  37
Leu Asn Ser 
1           

<210>  38
<211>  5
<212>  PRT
<213>  ˹
<400>  38
Arg Ile Val Met Arg 
1               5   

<210>  39
<211>  16
<212>  PRT
<213>  ˹
<400>  39
Ser Ile Tyr Asp Ser Gly Ser Thr Ser Tyr Ser Asp Pro Val Gln Gly 
1               5                   10                  15      

<210>  40
<211>  7
<212>  PRT
<213>  ˹
<400>  40
Gly Thr Ala Leu Ser Ser Tyr 
1               5           

<210>  41
<211>  5
<212>  PRT
<213>  ˹
<400>  41
Pro Ile Ala Met Ala 
1               5   

<210>  42
<211>  16
<212>  PRT
<213>  ˹
<400>  42
Gly Leu Thr Trp Thr Gly Arg Thr Tyr Tyr Ser Asp Ser Val Lys Gly 
1               5                   10                  15      

<210>  43
<211>  19
<212>  PRT
<213>  ˹
<400>  43
Gly Asp Asn Pro Asp Arg Arg Gly Ser Ser Trp Ser Ser Ser Ser Val 
1               5                   10                  15      
Tyr Glu Tyr 
            

<210>  44
<211>  5
<212>  PRT
<213>  ˹
<400>  44
Leu Asn Thr Met Arg 
1               5   

<210>  45
<211>  17
<212>  PRT
<213>  ˹
<400>  45
Ser Ile Tyr Ser Ser Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  46
<211>  7
<212>  PRT
<213>  ˹
<400>  46
Gln Thr Pro Leu Asn Val Tyr 
1               5           

<210>  47
<211>  5
<212>  PRT
<213>  ˹
<400>  47
Ser Tyr Pro Met Gly 
1               5   

<210>  48
<211>  16
<212>  PRT
<213>  ˹
<400>  48
Ala Ile Ser Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      

<210>  49
<211>  9
<212>  PRT
<213>  ˹
<400>  49
Arg Ser Pro Arg Val Pro Asn Asp Ser 
1               5                   

<210>  50
<211>  5
<212>  PRT
<213>  ˹
<400>  50
Arg Tyr Ala Met Arg 
1               5   

<210>  51
<211>  16
<212>  PRT
<213>  ˹
<400>  51
Ser Ile Tyr Ser Asp Gly Ser Ser Ala Tyr Ala Asp Ser Val Lys Asp 
1               5                   10                  15      

<210>  52
<211>  7
<212>  PRT
<213>  ˹
<400>  52
Asn Val Asp Ser Lys Ala Tyr 
1               5           

<210>  53
<211>  5
<212>  PRT
<213>  ˹
<400>  53
Gly Asn Tyr Gly Gly 
1               5   

<210>  54
<211>  16
<212>  PRT
<213>  ˹
<400>  54
Ser Met Ser Ser Ala Leu Gly Thr Lys Tyr Ala Asp Pro Val Lys Gly 
1               5                   10                  15      

<210>  55
<211>  13
<212>  PRT
<213>  ˹
<400>  55
Arg Val Arg Leu Ser Arg Gly Gly Trp Gly Ser Glu Tyr 
1               5                   10              

<210>  56
<211>  5
<212>  PRT
<213>  ˹
<400>  56
Ile Thr Ala Met Gly 
1               5   

<210>  57
<211>  16
<212>  PRT
<213>  ˹
<400>  57
Val Ile Thr Asp Arg Gly Arg Ala Ser Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      

<210>  58
<211>  11
<212>  PRT
<213>  ˹
<400>  58
His Arg Arg Thr Trp Pro His Pro Gly Asp Tyr 
1               5                   10      

<210>  59
<211>  5
<212>  PRT
<213>  ˹
<400>  59
Gly Asn Ala Val Ala 
1               5   

<210>  60
<211>  16
<212>  PRT
<213>  ˹
<400>  60
Val Ile Thr Arg Asp Gly Asp Thr Lys Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      

<210>  61
<211>  8
<212>  PRT
<213>  ˹
<400>  61
Ala Arg Gly Ala Ala Val Asp Ser 
1               5               

<210>  62
<211>  5
<212>  PRT
<213>  ˹
<400>  62
Ser Ser Ser Met Gly 
1               5   

<210>  63
<211>  17
<212>  PRT
<213>  ˹
<400>  63
Ala Ile Asn Arg Ile Gly Gly His Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  64
<211>  13
<212>  PRT
<213>  ˹
<400>  64
Ser Arg Ile Tyr Ser His Ser Ala Arg Asp Tyr Asp Tyr 
1               5                   10              

<210>  65
<211>  5
<212>  PRT
<213>  ˹
<400>  65
Ala Asn Tyr Met Gly 
1               5   

<210>  66
<211>  16
<212>  PRT
<213>  ˹
<400>  66
Thr Ile Asn Arg Phe Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      

<210>  67
<211>  7
<212>  PRT
<213>  ˹
<400>  67
Met Arg Pro Gly Asn Trp Tyr 
1               5           

<210>  68
<211>  5
<212>  PRT
<213>  ˹
<400>  68
Ser Ser Ser Ile Gly 
1               5   

<210>  69
<211>  17
<212>  PRT
<213>  ˹
<400>  69
Thr Met Asn Arg Ile Gly Gly His Thr Phe Tyr Ala Asp Pro Val Lys 
1               5                   10                  15      
Gly 
    

<210>  70
<211>  13
<212>  PRT
<213>  ˹
<400>  70
Ser Arg Ile Tyr Ser His Ser Pro Arg Asp Tyr Asp Tyr 
1               5                   10              

<210>  71
<211>  7
<212>  PRT
<213>  ˹
<400>  71
Gly Ser Thr Ser Met Ser Tyr 
1               5           

<210>  72
<211>  5
<212>  PRT
<213>  ˹
<400>  72
Tyr Arg Asp Gly Thr 
1               5   

<210>  73
<211>  3
<212>  PRT
<213>  ˹
<400>  73
Leu Asn Ser 
1           

<210>  74
<211>  7
<212>  PRT
<213>  ˹
<400>  74
Gly Ser Thr Phe Gly Arg Ile 
1               5           

<210>  75
<211>  5
<212>  PRT
<213>  ˹
<400>  75
Tyr Asp Ser Gly Ser 
1               5   

<210>  76
<211>  7
<212>  PRT
<213>  ˹
<400>  76
Gly Thr Ala Leu Ser Ser Tyr 
1               5           

<210>  77
<211>  7
<212>  PRT
<213>  ˹
<400>  77
Gly Arg Thr Ile Ser Pro Ile 
1               5           

<210>  78
<211>  5
<212>  PRT
<213>  ˹
<400>  78
Thr Trp Thr Gly Arg 
1               5   

<210>  79
<211>  19
<212>  PRT
<213>  ˹
<400>  79
Gly Asp Asn Pro Asp Arg Arg Gly Ser Ser Trp Ser Ser Ser Ser Val 
1               5                   10                  15      
Tyr Glu Tyr 
            

<210>  80
<211>  7
<212>  PRT
<213>  ˹
<400>  80
Gly Ser Ile Leu Ala Leu Asn 
1               5           

<210>  81
<211>  6
<212>  PRT
<213>  ˹
<400>  81
Tyr Ser Ser Gly Gly Ser 
1               5       

<210>  82
<211>  7
<212>  PRT
<213>  ˹
<400>  82
Gln Thr Pro Leu Asn Val Tyr 
1               5           

<210>  83
<211>  7
<212>  PRT
<213>  ˹
<400>  83
Gly Ser Thr Phe Ser Ser Tyr 
1               5           

<210>  84
<211>  5
<212>  PRT
<213>  ˹
<400>  84
Ser Ser Gly Gly Ser 
1               5   

<210>  85
<211>  9
<212>  PRT
<213>  ˹
<400>  85
Arg Ser Pro Arg Val Pro Asn Asp Ser 
1               5                   

<210>  86
<211>  7
<212>  PRT
<213>  ˹
<400>  86
Val Ser Thr Phe Thr Arg Tyr 
1               5           

<210>  87
<211>  5
<212>  PRT
<213>  ˹
<400>  87
Tyr Ser Asp Gly Ser 
1               5   

<210>  88
<211>  7
<212>  PRT
<213>  ˹
<400>  88
Asn Val Asp Ser Lys Ala Tyr 
1               5           

<210>  89
<211>  7
<212>  PRT
<213>  ˹
<400>  89
Gly Ile Thr Phe Ser Gly Asn 
1               5           

<210>  90
<211>  5
<212>  PRT
<213>  ˹
<400>  90
Ser Ser Ala Leu Gly 
1               5   

<210>  91
<211>  13
<212>  PRT
<213>  ˹
<400>  91
Arg Val Arg Leu Ser Arg Gly Gly Trp Gly Ser Glu Tyr 
1               5                   10              

<210>  92
<211>  7
<212>  PRT
<213>  ˹
<400>  92
Gly Ser Val Asn Ser Ile Thr 
1               5           

<210>  93
<211>  5
<212>  PRT
<213>  ˹
<400>  93
Thr Asp Arg Gly Arg 
1               5   

<210>  94
<211>  11
<212>  PRT
<213>  ˹
<400>  94
His Arg Arg Thr Trp Pro His Pro Gly Asp Tyr 
1               5                   10      

<210>  95
<211>  7
<212>  PRT
<213>  ˹
<400>  95
Gly Ser Ile Phe Ser Gly Asn 
1               5           

<210>  96
<211>  5
<212>  PRT
<213>  ˹
<400>  96
Thr Arg Asp Gly Asp 
1               5   

<210>  97
<211>  8
<212>  PRT
<213>  ˹
<400>  97
Ala Arg Gly Ala Ala Val Asp Ser 
1               5               

<210>  98
<211>  7
<212>  PRT
<213>  ˹
<400>  98
Glu Arg Thr Phe Ser Ser Ser 
1               5           

<210>  99
<211>  6
<212>  PRT
<213>  ˹
<400>  99
Asn Arg Ile Gly Gly His 
1               5       

<210>  100
<211>  13
<212>  PRT
<213>  ˹
<400>  100
Ser Arg Ile Tyr Ser His Ser Ala Arg Asp Tyr Asp Tyr 
1               5                   10              

<210>  101
<211>  7
<212>  PRT
<213>  ˹
<400>  101
Glu Ser Gly Phe Ser Ala Asn 
1               5           

<210>  102
<211>  5
<212>  PRT
<213>  ˹
<400>  102
Asn Arg Phe Gly Ser 
1               5   

<210>  103
<211>  7
<212>  PRT
<213>  ˹
<400>  103
Met Arg Pro Gly Asn Trp Tyr 
1               5           

<210>  104
<211>  7
<212>  PRT
<213>  ˹
<400>  104
Glu Arg Thr Phe Ser Ser Ser 
1               5           

<210>  105
<211>  6
<212>  PRT
<213>  ˹
<400>  105
Asn Arg Ile Gly Gly His 
1               5       

<210>  106
<211>  13
<212>  PRT
<213>  ˹
<400>  106
Ser Arg Ile Tyr Ser His Ser Pro Arg Asp Tyr Asp Tyr 
1               5                   10              

<210>  107
<211>  8
<212>  PRT
<213>  ˹
<400>  107
Gly Ser Thr Ser Met Ser Tyr Gly 
1               5               

<210>  108
<211>  7
<212>  PRT
<213>  ˹
<400>  108
Val Tyr Arg Asp Gly Thr Thr 
1               5           

<210>  109
<211>  5
<212>  PRT
<213>  ˹
<400>  109
Thr Ala Leu Asn Ser 
1               5   

<210>  110
<211>  8
<212>  PRT
<213>  ˹
<400>  110
Gly Ser Thr Phe Gly Arg Ile Val 
1               5               

<210>  111
<211>  7
<212>  PRT
<213>  ˹
<400>  111
Ile Tyr Asp Ser Gly Ser Thr 
1               5           

<210>  112
<211>  9
<212>  PRT
<213>  ˹
<400>  112
Asn Leu Gly Thr Ala Leu Ser Ser Tyr 
1               5                   

<210>  113
<211>  8
<212>  PRT
<213>  ˹
<400>  113
Gly Arg Thr Ile Ser Pro Ile Ala 
1               5               

<210>  114
<211>  7
<212>  PRT
<213>  ˹
<400>  114
Leu Thr Trp Thr Gly Arg Thr 
1               5           

<210>  115
<211>  21
<212>  PRT
<213>  ˹
<400>  115
Ala Ala Gly Asp Asn Pro Asp Arg Arg Gly Ser Ser Trp Ser Ser Ser 
1               5                   10                  15      
Ser Val Tyr Glu Tyr 
            20      

<210>  116
<211>  8
<212>  PRT
<213>  ˹
<400>  116
Gly Ser Ile Leu Ala Leu Asn Thr 
1               5               

<210>  117
<211>  8
<212>  PRT
<213>  ˹
<400>  117
Ile Tyr Ser Ser Gly Gly Ser Thr 
1               5               

<210>  118
<211>  9
<212>  PRT
<213>  ˹
<400>  118
Asn Val Gln Thr Pro Leu Asn Val Tyr 
1               5                   

<210>  119
<211>  8
<212>  PRT
<213>  ˹
<400>  119
Gly Ser Thr Phe Ser Ser Tyr Pro 
1               5               

<210>  120
<211>  7
<212>  PRT
<213>  ˹
<400>  120
Ile Ser Ser Gly Gly Ser Thr 
1               5           

<210>  121
<211>  11
<212>  PRT
<213>  ˹
<400>  121
Asn Thr Arg Ser Pro Arg Val Pro Asn Asp Ser 
1               5                   10      

<210>  122
<211>  8
<212>  PRT
<213>  ˹
<400>  122
Val Ser Thr Phe Thr Arg Tyr Ala 
1               5               

<210>  123
<211>  7
<212>  PRT
<213>  ˹
<400>  123
Ile Tyr Ser Asp Gly Ser Ser 
1               5           

<210>  124
<211>  9
<212>  PRT
<213>  ˹
<400>  124
Asn Ala Asn Val Asp Ser Lys Ala Tyr 
1               5                   

<210>  125
<211>  8
<212>  PRT
<213>  ˹
<400>  125
Gly Ile Thr Phe Ser Gly Asn Tyr 
1               5               

<210>  126
<211>  7
<212>  PRT
<213>  ˹
<400>  126
Met Ser Ser Ala Leu Gly Thr 
1               5           

<210>  127
<211>  15
<212>  PRT
<213>  ˹
<400>  127
Tyr Ala Arg Val Arg Leu Ser Arg Gly Gly Trp Gly Ser Glu Tyr 
1               5                   10                  15  

<210>  128
<211>  8
<212>  PRT
<213>  ˹
<400>  128
Gly Ser Val Asn Ser Ile Thr Ala 
1               5               

<210>  129
<211>  7
<212>  PRT
<213>  ˹
<400>  129
Ile Thr Asp Arg Gly Arg Ala 
1               5           

<210>  130
<211>  13
<212>  PRT
<213>  ˹
<400>  130
Asn Ala His Arg Arg Thr Trp Pro His Pro Gly Asp Tyr 
1               5                   10              

<210>  131
<211>  8
<212>  PRT
<213>  ˹
<400>  131
Gly Ser Ile Phe Ser Gly Asn Ala 
1               5               

<210>  132
<211>  7
<212>  PRT
<213>  ˹
<400>  132
Ile Thr Arg Asp Gly Asp Thr 
1               5           

<210>  133
<211>  10
<212>  PRT
<213>  ˹
<400>  133
Asn Thr Ala Arg Gly Ala Ala Val Asp Ser 
1               5                   10  

<210>  134
<211>  8
<212>  PRT
<213>  ˹
<400>  134
Glu Arg Thr Phe Ser Ser Ser Ser 
1               5               

<210>  135
<211>  8
<212>  PRT
<213>  ˹
<400>  135
Ile Asn Arg Ile Gly Gly His Ile 
1               5               

<210>  136
<211>  15
<212>  PRT
<213>  ˹
<400>  136
Ala Ser Ser Arg Ile Tyr Ser His Ser Ala Arg Asp Tyr Asp Tyr 
1               5                   10                  15  

<210>  137
<211>  8
<212>  PRT
<213>  ˹
<400>  137
Glu Ser Gly Phe Ser Ala Asn Tyr 
1               5               

<210>  138
<211>  7
<212>  PRT
<213>  ˹
<400>  138
Ile Asn Arg Phe Gly Ser Thr 
1               5           

<210>  139
<211>  9
<212>  PRT
<213>  ˹
<400>  139
Arg Ile Met Arg Pro Gly Asn Trp Tyr 
1               5                   

<210>  140
<211>  8
<212>  PRT
<213>  ˹
<400>  140
Glu Arg Thr Phe Ser Ser Ser Ser 
1               5               

<210>  141
<211>  8
<212>  PRT
<213>  ˹
<400>  141
Met Asn Arg Ile Gly Gly His Thr 
1               5               

<210>  142
<211>  15
<212>  PRT
<213>  ˹
<400>  142
Ala Ser Ser Arg Ile Tyr Ser His Ser Pro Arg Asp Tyr Asp Tyr 
1               5                   10                  15  
