﻿                         序列表
<110>  南京融捷康生物科技有限公司
<120>  人源化的抗IL-4Rα单域抗体及其应用
<160>  25
<170>  SIPOSequenceListing 1.0
<210>  1
<211>  24
<212>  PRT
<213>  人工序列
<400>  1
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala 
            20                  
<210>  2
<211>  24
<212>  PRT
<213>  人工序列
<400>  2
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala 
            20                  
<210>  3
<211>  6
<212>  PRT
<213>  人工序列
<400>  3
Ser Gly Asp Phe Tyr Cys 
1               5       
<210>  4
<211>  17
<212>  PRT
<213>  人工序列
<400>  4
Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala 
1               5                   10                  15      
Thr 
    
<210>  5
<211>  17
<212>  PRT
<213>  人工序列
<400>  5
Leu Gly Trp Phe Arg Gln Ala Pro Gly Gln Gly Leu Glu Ala Val Ala 
1               5                   10                  15      
Ala 
    
<210>  6
<211>  17
<212>  PRT
<213>  人工序列
<400>  6
Leu Gly Trp Phe Arg Gln Ala Pro Gly Gln Glu Arg Glu Ala Val Ala 
1               5                   10                  15      
Ala 
    
<210>  7
<211>  17
<212>  PRT
<213>  人工序列
<400>  7
Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ala Val Ala 
1               5                   10                  15      
Thr 
    
<210>  8
<211>  16
<212>  PRT
<213>  人工序列
<400>  8
Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ala Val Ala 
1               5                   10                  15      
<210>  9
<211>  17
<212>  PRT
<213>  人工序列
<400>  9
Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val Ala 
1               5                   10                  15      
Lys 
    
<210>  10
<211>  17
<212>  PRT
<213>  人工序列
<400>  10
Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val Ala 
1               5                   10                  15      
Thr 
    
<210>  11
<211>  17
<212>  PRT
<213>  人工序列
<400>  11
Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ala Val Ala 
1               5                   10                  15      
Ala 
    
<210>  12
<211>  8
<212>  PRT
<213>  人工序列
<400>  12
Ile Arg Ser Gly Gly Arg Ser Thr 
1               5               
<210>  13
<211>  38
<212>  PRT
<213>  人工序列
<400>  13
Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn 
1               5                   10                  15      
Ala Lys Asp Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
            20                  25                  30          
Thr Ala Met Tyr Tyr Cys 
        35              
<210>  14
<211>  38
<212>  PRT
<213>  人工序列
<400>  14
Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      
Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          
Thr Ala Val Tyr Tyr Cys 
        35              
<210>  15
<211>  38
<212>  PRT
<213>  人工序列
<400>  15
Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      
Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Ala Glu Asp 
            20                  25                  30          
Thr Ala Val Tyr Tyr Cys 
        35              
<210>  16
<211>  38
<212>  PRT
<213>  人工序列
<400>  16
Tyr Leu Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      
Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Ala Glu Asp 
            20                  25                  30          
Thr Ala Val Tyr Tyr Cys 
        35              
<210>  17
<211>  38
<212>  PRT
<213>  人工序列
<400>  17
Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      
Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Ala Glu Asp 
            20                  25                  30          
Thr Ala Val Tyr Tyr Cys 
        35              
<210>  18
<211>  12
<212>  PRT
<213>  人工序列
<400>  18
Ala Val Gly Val Asp Gly Asn Cys Arg Asn Tyr Trp 
1               5                   10          
<210>  19
<211>  12
<212>  PRT
<213>  人工序列
<400>  19
Ala Val Gly Val Asp Ala Asn Cys Arg Asn Tyr Trp 
1               5                   10          
<210>  20
<211>  10
<212>  PRT
<213>  人工序列
<400>  20
Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10  
<210>  21
<211>  10
<212>  PRT
<213>  人工序列
<400>  21
Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10  
<210>  22
<211>  115
<212>  PRT
<213>  人工序列
<400>  22
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Phe Tyr Cys Met Ala 
            20                  25                  30          
Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala Thr Ile 
        35                  40                  45              
Arg Ser Gly Gly Arg Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    50                  55                  60                  
Phe Thr Ile Ser Lys Asp Asn Ala Lys Asp Thr Leu Tyr Leu Gln Met 
65                  70                  75                  80  
Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Val Gly 
                85                  90                  95      
Val Asp Gly Asn Cys Arg Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 
<210>  23
<211>  1434
<212>  DNA
<213>  人工序列
<400>  23
caagtgcaac ttgtggaatc aggaggagga tcagtgcaag caggaggatc acttagactt        60
tcatgcgcag catcaggaga tttctattgt atggcatggt ttagacaagc acctggaaag       120
gagagggaag gagtggcaac aatcagatca ggaggaagat caacatacta cgcagattca       180
gtgaaaggaa gatttacaat ctcaaaggac aatgcaaagg acacccttta ccttcaaatg       240
aactcactta aacctgaaga tacagcaatg tactactgcg cagtgggagt ggatggaaac       300
tgcagaaact actggggcca ggggacacaa gtgacagtgt catcagagag caagtacggc       360
cctccttgcc ccagctgccc cgcccccgag tttctgggag gccccagcgt gtttctgttt       420
cctcccaagc ccaaagacac actgatgatc agcagaaccc ccgaggtgac atgcgtggtg       480
gtcgacgtga gccaagaaga tcccgaggtg cagttcaact ggtatgtgga cggcgtggag       540
gtgcacaacg ccaagaccaa gcctagggag gagcaattca acagcaccta cagagtggtg       600
agcgtgctga ccgtgctgca ccaagactgg ctgaacggca aggagtataa gtgtaaggtg       660
agcaacaagg gcctccccag cagcatcgag aagaccatct ccaaggccaa gggccagcct       720
agggagcctc aagtgtacac actgcccccc agccaagagg agatgaccaa aaaccaagtg       780
tctctgacat gcctcgtgaa gggcttctat cccagcgaca tcgccgtgga gtgggagagc       840
aatggccagc ccgagaataa ctacaagacc accccccccg tgctcgactc cgatggcagc       900
ttctttctgt actctaggct gaccgtggac aagtctaggt ggcaagaggg aaacgtgttc       960
agctgttccg tgatgcacga ggctctgcac aaccactaca cccagaagag cctctctctg      1020
tctctgggaa aggagagcaa gtacggccct ccttgcccca gctgccccca agtgcagctg      1080
gtggagagtg ggggcggtag cgtacaagcg ggcggcagcc tgagactgag ctgcgccgcc      1140
agcggcaaca ccttcagctt cagcacctac tgcatgggct ggttcagaca gagccccggc      1200
aaggagagag agggcagcct ggccaccatc tacgacgcca gcaccgccta cgccggcagc      1260
gtgaagggca gattcaccat cagcagagac aacagcaaga acatcctgta cctgcagatg      1320
aacaacctga gagccgagga caccgccgtg tactactgcg ccgccgccag atactgcatg      1380
ttctggagcc accccagcta ctggggccag ggcacccagg tgaccgtgag cagc            1434
<210>  24
<211>  478
<212>  PRT
<213>  人工序列
<400>  24
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Phe Tyr Cys Met Ala 
            20                  25                  30          
Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ala Val Ala Ala Ile 
        35                  40                  45              
Arg Ser Gly Gly Arg Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    50                  55                  60                  
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
65                  70                  75                  80  
Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Val Gly 
                85                  90                  95      
Val Asp Gly Asn Cys Arg Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala 
        115                 120                 125             
Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    130                 135                 140                 
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
145                 150                 155                 160 
Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
                165                 170                 175     
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            180                 185                 190         
Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        195                 200                 205             
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
    210                 215                 220                 
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
225                 230                 235                 240 
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
                245                 250                 255     
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            260                 265                 270         
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        275                 280                 285             
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    290                 295                 300                 
Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
305                 310                 315                 320 
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                325                 330                 335     
Ser Leu Ser Leu Ser Leu Gly Lys Glu Ser Lys Tyr Gly Pro Pro Cys 
            340                 345                 350         
Pro Ser Cys Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val 
        355                 360                 365             
Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Thr 
    370                 375                 380                 
Phe Ser Phe Ser Thr Tyr Cys Met Gly Trp Phe Arg Gln Ser Pro Gly 
385                 390                 395                 400 
Lys Glu Arg Glu Gly Ser Leu Ala Thr Ile Tyr Asp Ala Ser Thr Ala 
                405                 410                 415     
Tyr Ala Gly Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
            420                 425                 430         
Lys Asn Ile Leu Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr 
        435                 440                 445             
Ala Val Tyr Tyr Cys Ala Ala Ala Arg Tyr Cys Met Phe Trp Ser His 
    450                 455                 460                 
Pro Ser Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
465                 470                 475             
<210>  25
<211>  122
<212>  PRT
<213>  人工序列
<400>  25
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Thr Phe Ser Phe Ser 
            20                  25                  30          
Thr Tyr Cys Met Gly Trp Phe Arg Gln Ser Pro Gly Lys Glu Arg Glu 
        35                  40                  45              
Gly Ser Leu Ala Thr Ile Tyr Asp Gly Ser Thr Ala Tyr Ala Gly Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Val Asp Asn Ala Lys Asn Ile Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr 
                85                  90                  95      
Cys Ala Ala Ala Lys Tyr Cys Met Phe Trp Ser Asp Pro Ser Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         

