                         SEQUENCE LISTING

<110>  ݰ߻Ƽ޹˾
 
<120>  CLL1弰Ӧ

<130>  20DX1813FPPC

<160>  29    

<170>  PatentIn version 3.3

<210>  1
<211>  5
<212>  PRT
<213>  ˹

<220>
<223>  CLL123D7ɱCDR1

<400>  1

Arg Tyr Trp Met His 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  CLL123D7ɱCDR2

<400>  2

Tyr Ile Tyr Pro Gly Ser Gly Thr Ser Asn Tyr Asp Glu Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  3
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  CLL123D7ɱCDR3

<400>  3

Glu Ala Arg Tyr Thr Met Asp Tyr 
1               5               


<210>  4
<211>  10
<212>  PRT
<213>  ˹

<220>
<223>  CLL123D7ɱCDR1

<400>  4

Ser Ala Ser Ser Ser Val Ser Tyr Ile Tyr 
1               5                   10  


<210>  5
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  CLL123D7/19C1ɱCDR2

<400>  5

Asp Thr Ser Asn Leu Ala Ser 
1               5           


<210>  6
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  CLL123D7ɱCDR3

<400>  6

Gln Gln Trp Ser Ser Phe Pro 
1               5           


<210>  7
<211>  5
<212>  PRT
<213>  ˹

<220>
<223>  CLL119C1ɱCDR1

<400>  7

Ser Tyr Trp Ile Glu 
1               5   


<210>  8
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  CLL119C1ɱCDR2

<400>  8

Glu Ile Phe Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  12
<212>  PRT
<213>  ˹

<220>
<223>  CLL119C1ɱCDR3

<400>  9

Gly Gly Thr Tyr Asn Asp Tyr Ser Leu Phe Asp Tyr 
1               5                   10          


<210>  10
<211>  10
<212>  PRT
<213>  ˹

<220>
<223>  CLL119C1ɱCDR1

<400>  10

Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  11
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  CLL119C1ɱCDR3

<400>  11

Gln Gln Trp Ser Ser Tyr Pro 
1               5           


<210>  12
<211>  5
<212>  PRT
<213>  ˹

<220>
<223>  CLL127H4ɱCDR1

<400>  12

Gly Tyr His Met His 
1               5   


<210>  13
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  CLL127H4ɱCDR2

<400>  13

Arg Ile Asn Pro Tyr Asn Gly Ala Ala Ser His Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  14
<211>  13
<212>  PRT
<213>  ˹

<220>
<223>  CLL127H4ɱCDR3

<400>  14

Gly Trp Asp Tyr Asp Gly Gly Tyr Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  15
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  CLL127H4ɱCDR1

<400>  15

Lys Ser Ser Gln Ser Leu Leu Tyr Ser Asp Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  16
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  CLL127H4ɱCDR2

<400>  16

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  17
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  CLL127H4ɱCDR3

<400>  17

Gln Gln Tyr Tyr Thr Tyr Pro 
1               5           


<210>  18
<211>  117
<212>  PRT
<213>  ˹

<220>
<223>  CLL123D7ɱ

<400>  18

Gln Val Gln Leu Gln Gln Pro Gly Ser Asp Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Gly Ser Gly Thr Ser Asn Tyr Asp Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ala Arg Tyr Thr Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  19
<211>  106
<212>  PRT
<213>  ˹

<220>
<223>  CLL123D7ɱ

<400>  19

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Gly Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Phe Pro Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  20
<211>  121
<212>  PRT
<213>  ˹

<220>
<223>  CLL119C1ɱ

<400>  20

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Phe Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Thr Tyr Asn Asp Tyr Ser Leu Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  21
<211>  106
<212>  PRT
<213>  ˹

<220>
<223>  CLL119C1ɱ

<400>  21

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Phe 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  22
<211>  122
<212>  PRT
<213>  ˹

<220>
<223>  CLL127H4ɱ

<400>  22

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


His Met His Trp Val Lys Gln Ser His Val Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asn Pro Tyr Asn Gly Ala Ala Ser His Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Trp Asp Tyr Asp Gly Gly Tyr Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  23
<211>  113
<212>  PRT
<213>  ˹

<220>
<223>  CLL127H4ɱ

<400>  23

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asp Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Thr Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  24
<211>  122
<212>  PRT
<213>  ˹

<220>
<223>  hz27H4H1

<400>  24

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


His Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asn Pro Tyr Asn Gly Ala Ala Ser His Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Trp Asp Tyr Asp Gly Gly Tyr Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  25
<211>  113
<212>  PRT
<213>  ˹

<220>
<223>  hz27H4L1

<400>  25

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asp Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Thr Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  26
<211>  113
<212>  PRT
<213>  ˹

<220>
<223>  hz27H4L2

<400>  26

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asp Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Thr Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  27
<211>  113
<212>  PRT
<213>  ˹

<220>
<223>  hz27H4L3

<400>  27

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asp Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Thr Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  28
<211>  201
<212>  PRT
<213>  ˹

<220>
<223>  CLL1εİ

<400>  28

His Val Thr Leu Lys Ile Glu Met Lys Lys Met Asn Lys Leu Gln Asn 
1               5                   10                  15      


Ile Ser Glu Glu Leu Gln Arg Asn Ile Ser Leu Gln Leu Met Ser Asn 
            20                  25                  30          


Met Asn Ile Ser Asn Lys Ile Arg Asn Leu Ser Thr Thr Leu Gln Thr 
        35                  40                  45              


Ile Ala Thr Lys Leu Cys Arg Glu Leu Tyr Ser Lys Glu Gln Glu His 
    50                  55                  60                  


Lys Cys Lys Pro Cys Pro Arg Arg Trp Ile Trp His Lys Asp Ser Cys 
65                  70                  75                  80  


Tyr Phe Leu Ser Asp Asp Val Gln Thr Trp Gln Glu Ser Lys Met Ala 
                85                  90                  95      


Cys Ala Ala Gln Asn Ala Ser Leu Leu Lys Ile Asn Asn Lys Asn Ala 
            100                 105                 110         


Leu Glu Phe Ile Lys Ser Gln Ser Arg Ser Tyr Asp Tyr Trp Leu Gly 
        115                 120                 125             


Leu Ser Pro Glu Glu Asp Ser Thr Arg Gly Met Arg Val Asp Asn Ile 
    130                 135                 140                 


Ile Asn Ser Ser Ala Trp Val Ile Arg Asn Ala Pro Asp Leu Asn Asn 
145                 150                 155                 160 


Met Tyr Cys Gly Tyr Ile Asn Arg Leu Tyr Val Gln Tyr Tyr His Cys 
                165                 170                 175     


Thr Tyr Lys Lys Arg Met Ile Cys Glu Lys Met Ala Asn Pro Val Gln 
            180                 185                 190         


Leu Gly Ser Thr Tyr Phe Arg Glu Ala 
        195                 200     


<210>  29
<211>  245
<212>  PRT
<213>  ˹

<220>
<223>  CLL-11075.7VLVL

<400>  29

Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Asn Val Ile Ser Ser 
            20                  25                  30          


Tyr Val His Trp Tyr Gln Gln Arg Ser Gly Ala Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Gly Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Ser Leu Ser Leu Thr Cys 
    130                 135                 140                 


Ser Val Thr Gly Tyr Ser Ile Thr Ser Ala Tyr Tyr Trp Asn Trp Ile 
145                 150                 155                 160 


Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp Met Gly Tyr Ile Ser Tyr 
                165                 170                 175     


Asp Gly Arg Asn Asn Tyr Asn Pro Ser Leu Lys Asn Arg Ile Ser Ile 
            180                 185                 190         


Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu Lys Leu Asn Ser Val 
        195                 200                 205             


Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Lys Glu Gly Asp Tyr 
    210                 215                 220                 


Asp Val Gly Asn Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


