﻿                         序列表

<110>  深圳市瑞吉生物科技有限公司

<120>  一种编码CAR基因的mRNA、组合mRNA、构建方法、CAR-T细胞和方法

<160>  9

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  2184
<212>  RNA
<213>  人工序列(Artificial Sequence)

<400>  1
cugauguucc uaguacugcc ucugauauuc cuagugcuau aacuaauguu ucuacugcug        60
cuguuucugu aggucuacug ugucugaugu aggagggaca gacggagaga cccucugucu       120
cagugguagu caacgucccg uucaguccug uagagauuca uaaacuuaac cauagucguc       180
uuuggucuac cuugacaauu ugaggacuag augguaugua guucuaaugu gaguccucag       240
gguaguucca agucaccguc acccagaccu ugucuaauaa gagaguggua aucguuggac       300
cucguucuuc uauaacggug aaugaaaacg guugucccau uaugcgaagg caugugcaag       360
ccuccccccu gauucaaccu uuauuguccg agguggagac cuaggccguu cgggccuaga       420
ccgcucccua ggugguuccc gcuccacuuu gacguccuca guccuggacc ggaccaccgc       480
gggagugucu cggacaggca guguacguga cagagucccc agaguaaugg gcugauacca       540
cauucgaccu aagcggucgg aggugcuuuc ccagaccuca ccgacccuca uuauacccca       600
ucacuuuggu guaugauauu aagucgagag uuuaggucug acugguagua guuccuguug       660
agguucucgg uucaaaagaa uuuuuacuug ucagacguuu gacuacugug ucgguaaaug       720
augacacggu uuguaauaau gaugccacca ucgauacgau accugaugac cccaguuccu       780
uggagucagu ggcagaggag ucgccggcgu ccaugguggu guugcgggcg aggagccggu       840
ggcugcgguc gcgguugaua acgcucaguc ggagagucag acgcuggacu ccgaacagcu       900
ggucgucggc cuccgcguca cgugugcucc cccgaccuga agcggacacu aucuucugga       960
ggaagauucg ggaaaaccca cgaccaccac caaccaccuc aggaccgaac gauaucgaac      1020
gaucauuguc accggaaaua auaaaagacc cacucccgau cggacucuca cuucaagucg      1080
uccucgcguc ugcgggggcg cauggucguc ccggucuugg ucgagauauu gcucgaguua      1140
gauccugcuu cucuccucau gcuacaaaac cuguucucug caccggcccu gggacucuac      1200
cccccuuucg gcgucucuuc cuucuuggga guccuuccgg acauguuacu ugacgucuuu      1260
cuauucuacc gccuccggau gucacucuaa cccuacuuuc cgcucgcggc cuccccguuc      1320
cccgugcuac cggaaauggu cccagaguca ugucgguggu uccuguggau gcugcgggaa      1380
guguacgucc gggacggggg agcgcgaucg cggugcuuga agagagacaa uuucguucgu      1440
ccgcugcacc uucuuuuggg gccagggcac ucguucccgc uccucgacaa guggccccac      1500
cacggguagg accagcucga ccugccgcug cauuugccgg uguucaaguc gcacaggccg      1560
cucccgcucc cgcuacggug gaugccguuc gacugggacu ucaaguagac gugguggccg      1620
uucgacgggc acgggaccgg gugggagcac uggugggacu ggaugccgca cgucacgaag      1680
ucggcgaugg ggcuggugua cuucgucgug cugaagaagu ucaggcggua cgggcuuccg      1740
augcaggucc ucgcguggua gaagaaguuc cugcugccgu ugauguucug ggcgcggcuc      1800
cacuucaagc ucccgcugug ggaccacuug gcguagcucg acuucccgua gcugaaguuc      1860
cuccugccgu uguaggaccc cguguucgac cucauguuga uguugucggu guugcagaua      1920
uaguaccggc uguucgucuu cuugccguag uuccacuuga aguucuaggc gguguuguag      1980
cuccugccgu cgcacgucga gcggcuggug auggucgucu ugugggggua gccgcugccg      2040
gggcacgacg acgggcuguu ggugauggac ucguggguca ggcgggacuc guuucugggg      2100
uugcucuucg cgcuagugua ccaggacgac cucaagcacu ggcggcggcc cuagugagag      2160
ccguaccugc ucgacauguu cauu                                             2184

<210>  2
<211>  2310
<212>  RNA
<213>  人工序列(Artificial Sequence)

<400>  2
cugauguucc uaguacugcc ucugauauuc cuagugcuau aacuaauguu ucuacugcug        60
cuguuucugu aggucuacug ugucugaugu aggagggaca gacggagaga cccucugucu       120
cagugguagu caacgucccg uucaguccug uagagauuca uaaacuuaac cauagucguc       180
uuuggucuac cuugacaauu ugaggacuag augguaugua guucuaaugu gaguccucag       240
gguaguucca agucaccguc acccagaccu ugucuaauaa gagaguggua aucguuggac       300
cucguucuuc uauaacggug aaugaaaacg guugucccau uaugcgaagg caugugcaag       360
ccuccccccu gauucaaccu uuauuguccg agguggagac cuaggccguu cgggccuaga       420
ccgcucccua ggugguuccc gcuccacuuu gacguccuca guccuggacc ggaccaccgc       480
gggagugucu cggacaggca guguacguga cagagucccc agaguaaugg gcugauacca       540
cauucgaccu aagcggucgg aggugcuuuc ccagaccuca ccgacccuca uuauacccca       600
ucacuuuggu guaugauauu aagucgagag uuuaggucug acugguagua guuccuguug       660
agguucucgg uucaaaagaa uuuuuacuug ucagacguuu gacuacugug ucgguaaaug       720
augacacggu uuguaauaau gaugccacca ucgauacgau accugaugac cccaguuccu       780
uggagucagu ggcagaggag ucgccggcgu ccaugguggu guugcgggcg aggagccggu       840
ggcugcgguc gcgguugaua acgcucaguc ggagagucag acgcuggacu ccgaacagcu       900
ggucgucggc cuccgcguca cgugugcucc cccgaccuga agcggacacu aucuucugga       960
ggaagauucg ggaaaaccca cgaccaccac caaccaccuc aggaccgaac gauaucgaac      1020
gaucauuguc accggaaaua auaaaagacc cacuccuuug ccccgucuuu cuuugaggac      1080
auauauaagu uuguugguaa auacucuggu cauguuugau gaguucuccu ucuaccgaca      1140
ucgacggcua aaggucuucu ucuucuuccu ccuacacuug accgaucgga cucucacuuc      1200
aagucguccu cgcgucugcg ggggcgcaug gucgucccgg ucuuggucga gauauugcuc      1260
gaguuagauc cugcuucucu ccucaugcua caaaaccugu ucucugcacc ggcccuggga      1320
cucuaccccc cuuucggcgu cucuuccuuc uugggagucc uuccggacau guuacuugac      1380
gucuuucuau ucuaccgccu ccggauguca cucuaacccu acuuuccgcu cgcggccucc      1440
ccguuccccg ugcuaccgga aaugguccca gagucauguc ggugguuccu guggaugcug      1500
cgggaagugu acguccggga cgggggagcg cgaucgcggu gcuugaagag agacaauuuc      1560
guucguccgc ugcaccuucu uuuggggcca gggcacucgu ucccgcuccu cgacaagugg      1620
ccccaccacg gguaggacca gcucgaccug ccgcugcauu ugccgguguu caagucgcac      1680
aggccgcucc cgcucccgcu acgguggaug ccguucgacu gggacuucaa guagacgugg      1740
uggccguucg acgggcacgg gaccgggugg gagcacuggu gggacuggau gccgcacguc      1800
acgaagucgg cgauggggcu gguguacuuc gucgugcuga agaaguucag gcgguacggg      1860
cuuccgaugc agguccucgc gugguagaag aaguuccugc ugccguugau guucugggcg      1920
cggcuccacu ucaagcuccc gcugugggac cacuuggcgu agcucgacuu cccguagcug      1980
aaguuccucc ugccguugua ggaccccgug uucgaccuca uguugauguu gucgguguug      2040
cagauauagu accggcuguu cgucuucuug ccguaguucc acuugaaguu cuaggcggug      2100
uuguagcucc ugccgucgca cgucgagcgg cuggugaugg ucgucuugug gggguagccg      2160
cugccggggc acgacgacgg gcuguuggug auggacucgu gggucaggcg ggacucguuu      2220
cugggguugc ucuucgcgcu aguguaccag gacgaccuca agcacuggcg gcggcccuag      2280
ugagagccgu accugcucga cauguucauu                                       2310

<210>  3
<211>  2304
<212>  RNA
<213>  人工序列(Artificial Sequence)

<400>  3
cugauguucc uaguacugcc ucugauauuc cuagugcuau aacuaauguu ucuacugcug        60
cuguuucugu aggucuacug ugucugaugu aggagggaca gacggagaga cccucugucu       120
cagugguagu caacgucccg uucaguccug uagagauuca uaaacuuaac cauagucguc       180
uuuggucuac cuugacaauu ugaggacuag augguaugua guucuaaugu gaguccucag       240
gguaguucca agucaccguc acccagaccu ugucuaauaa gagaguggua aucguuggac       300
cucguucuuc uauaacggug aaugaaaacg guugucccau uaugcgaagg caugugcaag       360
ccuccccccu gauucaaccu uuauuguccg agguggagac cuaggccguu cgggccuaga       420
ccgcucccua ggugguuccc gcuccacuuu gacguccuca guccuggacc ggaccaccgc       480
gggagugucu cggacaggca guguacguga cagagucccc agaguaaugg gcugauacca       540
cauucgaccu aagcggucgg aggugcuuuc ccagaccuca ccgacccuca uuauacccca       600
ucacuuuggu guaugauauu aagucgagag uuuaggucug acugguagua guuccuguug       660
agguucucgg uucaaaagaa uuuuuacuug ucagacguuu gacuacugug ucgguaaaug       720
augacacggu uuguaauaau gaugccacca ucgauacgau accugaugac cccaguuccu       780
uggagucagu ggcagaggag ucgccggcgu ccaugguggu guugcgggcg aggagccggu       840
ggcugcgguc gcgguugaua acgcucaguc ggagagucag acgcuggacu ccgaacagcu       900
ggucgucggc cuccgcguca cgugugcucc cccgaccuga agcggacacu aucuucugga       960
ggaagauucg ggaaaaccca cgaccaccac caaccaccuc aggaccgaac gauaucgaac      1020
gaucauuguc accggaaaua auaaaagacc cacuccucau ucuccucguc cgaggacgug      1080
ucacugaugu acuuguacug aggguccgcc gggccugggu gggcguucgu aauggucggg      1140
auacggggug gugcgcugaa gcgucggaua gcgaggcgau cggacucuca cuucaagucg      1200
uccucgcguc ugcgggggcg cauggucguc ccggucuugg ucgagauauu gcucgaguua      1260
gauccugcuu cucuccucau gcuacaaaac cuguucucug caccggcccu gggacucuac      1320
cccccuuucg gcgucucuuc cuucuuggga guccuuccgg acauguuacu ugacgucuuu      1380
cuauucuacc gccuccggau gucacucuaa cccuacuuuc cgcucgcggc cuccccguuc      1440
cccgugcuac cggaaauggu cccagaguca ugucgguggu uccuguggau gcugcgggaa      1500
guguacgucc gggacggggg agcgcgaucg cggugcuuga agagagacaa uuucguucgu      1560
ccgcugcacc uucuuuuggg gccagggcac ucguucccgc uccucgacaa guggccccac      1620
cacggguagg accagcucga ccugccgcug cauuugccgg uguucaaguc gcacaggccg      1680
cucccgcucc cgcuacggug gaugccguuc gacugggacu ucaaguagac gugguggccg      1740
uucgacgggc acgggaccgg gugggagcac uggugggacu ggaugccgca cgucacgaag      1800
ucggcgaugg ggcuggugua cuucgucgug cugaagaagu ucaggcggua cgggcuuccg      1860
augcaggucc ucgcguggua gaagaaguuc cugcugccgu ugauguucug ggcgcggcuc      1920
cacuucaagc ucccgcugug ggaccacuug gcguagcucg acuucccgua gcugaaguuc      1980
cuccugccgu uguaggaccc cguguucgac cucauguuga uguugucggu guugcagaua      2040
uaguaccggc uguucgucuu cuugccguag uuccacuuga aguucuaggc gguguuguag      2100
cuccugccgu cgcacgucga gcggcuggug auggucgucu ugugggggua gccgcugccg      2160
gggcacgacg acgggcuguu ggugauggac ucguggguca ggcgggacuc guuucugggg      2220
uugcucuucg cgcuagugua ccaggacgac cucaagcacu ggcggcggcc cuagugagag      2280
ccguaccugc ucgacauguu cauu                                             2304

<210>  4
<211>  2430
<212>  RNA
<213>  人工序列(Artificial Sequence)

<400>  4
cugauguucc uaguacugcc ucugauauuc cuagugcuau aacuaauguu ucuacugcug        60
cuguuucugu aggucuacug ugucugaugu aggagggaca gacggagaga cccucugucu       120
cagugguagu caacgucccg uucaguccug uagagauuca uaaacuuaac cauagucguc       180
uuuggucuac cuugacaauu ugaggacuag augguaugua guucuaaugu gaguccucag       240
gguaguucca agucaccguc acccagaccu ugucuaauaa gagaguggua aucguuggac       300
cucguucuuc uauaacggug aaugaaaacg guugucccau uaugcgaagg caugugcaag       360
ccuccccccu gauucaaccu uuauuguccg agguggagac cuaggccguu cgggccuaga       420
ccgcucccua ggugguuccc gcuccacuuu gacguccuca guccuggacc ggaccaccgc       480
gggagugucu cggacaggca guguacguga cagagucccc agaguaaugg gcugauacca       540
cauucgaccu aagcggucgg aggugcuuuc ccagaccuca ccgacccuca uuauacccca       600
ucacuuuggu guaugauauu aagucgagag uuuaggucug acugguagua guuccuguug       660
agguucucgg uucaaaagaa uuuuuacuug ucagacguuu gacuacugug ucgguaaaug       720
augacacggu uuguaauaau gaugccacca ucgauacgau accugaugac cccaguuccu       780
uggagucagu ggcagaggag ucgccggcgu ccaugguggu guugcgggcg aggagccggu       840
ggcugcgguc gcgguugaua acgcucaguc ggagagucag acgcuggacu ccgaacagcu       900
ggucgucggc cuccgcguca cgugugcucc cccgaccuga agcggacacu aucuucugga       960
ggaagauucg ggaaaaccca cgaccaccac caaccaccuc aggaccgaac gauaucgaac      1020
gaucauuguc accggaaaua auaaaagacc cacuccuuug ccccgucuuu cuuugaggac      1080
auauauaagu uuguugguaa auacucuggu cauguuugau gaguucuccu ucuaccgaca      1140
ucgacggcua aaggucuucu ucuucuuccu ccuacacuug acucauucuc cucguccgag      1200
gacgugucac ugauguacuu guacugaggg uccgccgggc cugggugggc guucguaaug      1260
gucgggauac gggguggugc gcugaagcgu cggauagcga ggcgaucgga cucucacuuc      1320
aagucguccu cgcgucugcg ggggcgcaug gucgucccgg ucuuggucga gauauugcuc      1380
gaguuagauc cugcuucucu ccucaugcua caaaaccugu ucucugcacc ggcccuggga      1440
cucuaccccc cuuucggcgu cucuuccuuc uugggagucc uuccggacau guuacuugac      1500
gucuuucuau ucuaccgccu ccggauguca cucuaacccu acuuuccgcu cgcggccucc      1560
ccguuccccg ugcuaccgga aaugguccca gagucauguc ggugguuccu guggaugcug      1620
cgggaagugu acguccggga cgggggagcg cgaucgcggu gcuugaagag agacaauuuc      1680
guucguccgc ugcaccuucu uuuggggcca gggcacucgu ucccgcuccu cgacaagugg      1740
ccccaccacg gguaggacca gcucgaccug ccgcugcauu ugccgguguu caagucgcac      1800
aggccgcucc cgcucccgcu acgguggaug ccguucgacu gggacuucaa guagacgugg      1860
uggccguucg acgggcacgg gaccgggugg gagcacuggu gggacuggau gccgcacguc      1920
acgaagucgg cgauggggcu gguguacuuc gucgugcuga agaaguucag gcgguacggg      1980
cuuccgaugc agguccucgc gugguagaag aaguuccugc ugccguugau guucugggcg      2040
cggcuccacu ucaagcuccc gcugugggac cacuuggcgu agcucgacuu cccguagcug      2100
aaguuccucc ugccguugua ggaccccgug uucgaccuca uguugauguu gucgguguug      2160
cagauauagu accggcuguu cgucuucuug ccguaguucc acuugaaguu cuaggcggug      2220
uuguagcucc ugccgucgca cgucgagcgg cuggugaugg ucgucuugug gggguagccg      2280
cugccggggc acgacgacgg gcuguuggug auggacucgu gggucaggcg ggacucguuu      2340
cugggguugc ucuucgcgcu aguguaccag gacgaccuca agcacuggcg gcggcccuag      2400
ugagagccgu accugcucga cauguucauu                                       2430

<210>  5
<211>  543
<212>  RNA
<213>  人工序列(Artificial Sequence)

<400>  5
uaccucuguc ugugugagga cgauacccau gacgacgaga cccaaggucc aaggugacca        60
cugccuaggc gcggcugguc gucgucgugg uuuuuuuggg ucgacgucga ccuuguagac       120
gacgaccuag acgucuacua agacuugccg uaauuguuga uauuuuuggg cuuugacugg       180
gcguacgacu ggaaauuuaa aauauacggc uuuuuucgcu ggcuugacuu uguagacguc       240
acggaccuuc uucuugacuu uggcgaccuu cuucacgacu uggaccgcgu cucguuuuug       300
aaaguagacg cgggcgcgcu agacuaaucg uuguaauugc acuaacacga ccuugacuuu       360
ccgucgcuuu gguggaaaua cacgcuuaua cgccuacuuu ggcgcuggua acaccuuaaa       420
gacuuggcga ccuaauggaa acgcgucucg uaauaaucgu gggacuggcg ccggcgacuu       480
guuuuugagu agagucuucu ccuagacuua ucgcggcagc ugguaguagu aguaguagua       540
acu                                                                     543

<210>  6
<211>  486
<212>  RNA
<213>  人工序列(Artificial Sequence)

<400>  6
uacagagcuc cgguuauauc ggcccuccug uuguugacau gcgugaaggg ucaaccaguc        60
agaguauaca auaaccuuaa ugccugucgg aaaucaguuc aauuuuggaa gaaagucugc       120
uuucugguua accuguugua ggacaacugc cugagggauu acguucugaa guucccaaua       180
gagcccacag uccgugauag ucuuuacuau gucaagaugg accaucucca guacggcguc       240
cgacuuuuug uaccagggcu cuauuuccuu guagauuuaa gcgaaccgcu cuuugauuuc       300
ugggauuccu acgcagacgc ggcaacagug gccaaaaacg guacacucuu auucaguuuc       360
cggcaccuug uucaauucag acugaaauug uucgaugucc ugguuccuca cauauuccgg       420
uacuuacuca agcuauaaaa guauuugaca uaacuucgaa uguacuacua auucuacuuu       480
ucgauu                                                                  486

<210>  7
<211>  591
<212>  RNA
<213>  人工序列(Artificial Sequence)

<400>  7
gcguuggacg gccaccgcug gggccuaggc ccguacaaag gcacggacgu aguaucgguc        60
uuggacgacg cgcgccacuc guuguacgac gucuuucgcg cggucuggga ccuuaaaaua       120
ggcacguggu cgcuucuuua acuaguacuu cuauaauggu uucuauuuug gucguggcac       180
cuucgcacgg acggcgaccu ugacugguuu uugcuuucga cggacuuguc ggcgcuuugg       240
ucgaaauaau gguugccguc gacggaccgc ucggcguuuu ggucgaaaua cuaccgcgac       300
acggacucgu cguaaauacu ucuagacuuu uacauagucc accuuaaauu uugguacuug       360
cgcuuugacg acuaccuagg cuuugcgguc uaaaaagacc uagucuugua cgaccgccac       420
uaacuacuug acuacguccg cgacuugaaa uugucgcuuu ggcacggcgu cuuuucgucg       480
gaccuucuug gccuaaaaau auuuugguuu uaauuugaca cguaagacga cguacgcaaa       540
gcguaagcgc gccacuggua acuagcgcac uacucgauag acuugcgcuc g                591

<210>  8
<211>  918
<212>  RNA
<213>  人工序列(Artificial Sequence)

<400>  8
uaaacccuug acuuuuuucu acacauacac caccuugacc uaaccauagg ccuacgcggc        60
ccgcuuuacc accacgacug gacgcuaugg ggccuucuuc uaccguaaug gaccugggac       120
cuagucucgu cgcuucacga cccgucgccg uuuugggacu gguaagucca cuuucuuaaa       180
ccgcuacgcc cggucauaug gacgguauuu ccgccgcuuc acgacucggu aucggacgac       240
gacgacguau uuuuucuucu accguaaacc ucguggcuau aagacuuucu agucuuucuu       300
ggcuuuuugu uuuggaaaga cgcgacgcuu cgcuuuuuga uaucgccggc gaaauggacg       360
accaccgacu ggugguaauc guggcuagac uggaaaucgc acuuuucguc ggcgccgucg       420
ucgcuaggcg ucccgcacug gacgccgcgc cgcugggacu cgcgccuugc gcacgcgccg       480
cuauuguuuc uuauacuuau aucgcaccuu acgguccuuc uaucgcgcac gggccgccgc       540
cuucuuucgg acggcuaacu ucacuaccac cuacgccacg uauuugacuu uauacuuuug       600
auauggucgu cgaaaaaaua agcgcuauaa uaauuuggcc uaggcggcuu uuuggacguc       660
gacuuuggcg acuuuuuguc ggcgguccac cuucacucga cccuuauagg ccuauggacc       720
ucguggggcg uaucgauaaa aucggacugg aaaacgcacg uccacguccc guuuucguuu       780
gcgcuuuuuu uucuagcgca caaauggcua uuuuggucgc gcuggcacua aacggcguuu       840
uugcgcucgu aaucgcacgc gcgcguccua gcgauaauau cgucgucgac cucgcuuacc       900
cgcucgcacg gcacgucg                                                     918

<210>  9
<211>  231
<212>  RNA
<213>  人工序列(Artificial Sequence)

<400>  9
ccgugguugc uacgccuucu aacgacggac ucgcacuggg ucuuuggcua aggcccgaua        60
uaacacgcgu ugaaaguaau agacgacuaa uuucuaccga cggcgcacgg ccgccaccac       120
aaaugguggg acgcgccggc ggucgacacg cgcggcggcc uagucggcac ccaccuugcg       180
uaauaagucg cggacgucgc guggucgcgc uuuuacuuug cggcgucguc g                231

