                         SEQUENCE LISTING

<110>  Xiamen University
       NucMito Pharmaceuticals Company Limited
 
<120>  RXR BINDERS AND RXR/PLK1 MODULATORS

<130>  294A003WO01

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  462
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (56)..(56)
<223>  PHOSPHORYLATION

<400>  1

Met Asp Thr Lys His Phe Leu Pro Leu Asp Phe Ser Thr Gln Val Asn 
1               5                   10                  15      


Ser Ser Leu Thr Ser Pro Thr Gly Arg Gly Ser Met Ala Ala Pro Ser 
            20                  25                  30          


Leu His Pro Ser Leu Gly Pro Gly Ile Gly Ser Pro Gly Gln Leu His 
        35                  40                  45              


Ser Pro Ile Ser Thr Leu Ser Ser Pro Ile Asn Gly Met Gly Pro Pro 
    50                  55                  60                  


Phe Ser Val Ile Ser Ser Pro Met Gly Pro His Ser Met Ser Val Pro 
65                  70                  75                  80  


Thr Thr Pro Thr Leu Gly Phe Ser Thr Gly Ser Pro Gln Leu Ser Ser 
                85                  90                  95      


Pro Met Asn Pro Val Ser Ser Ser Glu Asp Ile Lys Pro Pro Leu Gly 
            100                 105                 110         


Leu Asn Gly Val Leu Lys Val Pro Ala His Pro Ser Gly Asn Met Ala 
        115                 120                 125             


Ser Phe Thr Lys His Ile Cys Ala Ile Cys Gly Asp Arg Ser Ser Gly 
    130                 135                 140                 


Lys His Tyr Gly Val Tyr Ser Cys Glu Gly Cys Lys Gly Phe Phe Lys 
145                 150                 155                 160 


Arg Thr Val Arg Lys Asp Leu Thr Tyr Thr Cys Arg Asp Asn Lys Asp 
                165                 170                 175     


Cys Leu Ile Asp Lys Arg Gln Arg Asn Arg Cys Gln Tyr Cys Arg Tyr 
            180                 185                 190         


Gln Lys Cys Leu Ala Met Gly Met Lys Arg Glu Ala Val Gln Glu Glu 
        195                 200                 205             


Arg Gln Arg Gly Lys Asp Arg Asn Glu Asn Glu Val Glu Ser Thr Ser 
    210                 215                 220                 


Ser Ala Asn Glu Asp Met Pro Val Glu Arg Ile Leu Glu Ala Glu Leu 
225                 230                 235                 240 


Ala Val Glu Pro Lys Thr Glu Thr Tyr Val Glu Ala Asn Met Gly Leu 
                245                 250                 255     


Asn Pro Ser Ser Pro Asn Asp Pro Val Thr Asn Ile Cys Gln Ala Ala 
            260                 265                 270         


Asp Lys Gln Leu Phe Thr Leu Val Glu Trp Ala Lys Arg Ile Pro His 
        275                 280                 285             


Phe Ser Glu Leu Pro Leu Asp Asp Gln Val Ile Leu Leu Arg Ala Gly 
    290                 295                 300                 


Trp Asn Glu Leu Leu Ile Ala Ser Phe Ser His Arg Ser Ile Ala Val 
305                 310                 315                 320 


Lys Asp Gly Ile Leu Leu Ala Thr Gly Leu His Val His Arg Asn Ser 
                325                 330                 335     


Ala His Ser Ala Gly Val Gly Ala Ile Phe Asp Arg Val Leu Thr Glu 
            340                 345                 350         


Leu Val Ser Lys Met Arg Asp Met Gln Met Asp Lys Thr Glu Leu Gly 
        355                 360                 365             


Cys Leu Arg Ala Ile Val Leu Phe Asn Pro Asp Ser Lys Gly Leu Ser 
    370                 375                 380                 


Asn Pro Ala Glu Val Glu Ala Leu Arg Glu Lys Val Tyr Ala Ser Leu 
385                 390                 395                 400 


Glu Ala Tyr Cys Lys His Lys Tyr Pro Glu Gln Pro Gly Arg Phe Ala 
                405                 410                 415     


Lys Leu Leu Leu Arg Leu Pro Ala Leu Arg Ser Ile Gly Leu Lys Cys 
            420                 425                 430         


Leu Glu His Leu Phe Phe Phe Lys Leu Ile Gly Asp Thr Pro Ile Asp 
        435                 440                 445             


Thr Phe Leu Met Glu Met Leu Glu Ala Pro His Gln Met Thr 
    450                 455                 460         


<210>  2
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asp Thr Lys His Phe Leu Pro Leu Asp Phe Ser Thr Gln Val Asn 
1               5                   10                  15      


Ser Ser Leu Thr Ser Pro Thr Gly Arg Gly Ser Met Ala Ala Pro Ser 
            20                  25                  30          


Leu His Pro Ser Leu Gly Pro Gly Ile Gly Ser Pro Gly Gln Leu His 
        35                  40                  45              


Ser Pro Ile Ser Thr Leu Ser Ser Pro Ile Asn Gly Met Gly Pro Pro 
    50                  55                  60                  


Phe Ser Val Ile Ser Ser Pro Met Gly Pro His Ser Met Ser Val Pro 
65                  70                  75                  80  


Thr Thr Pro Thr Leu Gly Phe Ser Thr Gly Ser Pro Gln Leu Ser Ser 
                85                  90                  95      


Pro Met Asn Pro Val Ser Ser Ser Glu Asp Ile Lys Pro Pro Leu Gly 
            100                 105                 110         


Leu Asn Gly Val Leu Lys Val Pro Ala His Pro Ser Gly Asn Met Ala 
        115                 120                 125             


Ser Phe Thr Lys His Ile Cys Ala Ile Cys Gly Asp Arg Ser Ser Gly 
    130                 135                 140                 


Lys His Tyr Gly Val Tyr Ser Cys Glu Gly Cys Lys Gly Phe Phe Lys 
145                 150                 155                 160 


Arg Thr Val Arg Lys Asp Leu Thr Tyr Thr Cys Arg Asp Asn Lys Asp 
                165                 170                 175     


Cys Leu Ile Asp Lys Arg Gln Arg Asn Arg Cys Gln Tyr Cys Arg Tyr 
            180                 185                 190         


Gln Lys Cys Leu Ala Met Gly Met Lys Arg Glu Ala Val Gln Glu Glu 
        195                 200                 205             


Arg Gln Arg Gly Lys Asp Arg Asn Glu Asn Glu Val Glu Ser Thr Ser 
    210                 215                 220                 


Ser Ala Asn Glu Asp Met Pro Val Glu Arg Ile Leu Glu Ala Glu Leu 
225                 230                 235                 240 


Ala Val Glu Pro Lys Thr Glu Thr Tyr Val Glu Ala Asn Met Gly Leu 
                245                 250                 255     


Asn Pro Ser Ser Pro Asn Asp Pro Val Thr Asn Ile Cys Gln Ala Ala 
            260                 265                 270         


Asp Lys Gln Leu Phe Thr Leu Val Glu Trp Ala Lys Arg Ile Pro His 
        275                 280                 285             


Phe Ser Glu Leu Pro Leu Asp Asp Gln Val Ile Leu Leu Arg Ala Gly 
    290                 295                 300                 


Trp Asn Glu Leu Leu Ile Ala Ser Phe Ser His Arg Ser Ile Ala Val 
305                 310                 315                 320 


Lys Asp Gly Ile Leu Leu Ala Thr Gly Leu His Val His Arg Asn Ser 
                325                 330                 335     


Ala His Ser Ala Gly Val Gly Ala Ile Phe Asp Arg Val Leu Thr Glu 
            340                 345                 350         


Leu Val Ser Lys Met Arg Asp Met Gln Met Asp Lys Thr Glu Leu Gly 
        355                 360                 365             


Cys Leu Arg Ala Ile Val Leu Phe Asn Pro Asp Ser Lys Gly Leu Ser 
    370                 375                 380                 


Asn Pro Ala Glu Val Glu Ala Leu Arg Glu Lys Val Tyr Ala Ser Leu 
385                 390                 395                 400 


Glu Ala Tyr Cys Lys His Lys Tyr Pro Glu Gln Pro Gly Arg Phe Ala 
                405                 410                 415     


Lys Leu Leu Leu Arg Leu Pro Ala Leu Arg Ser Ile Gly Leu Lys Cys 
            420                 425                 430         


Leu Glu His Leu Phe Phe Phe Lys Leu Ile Gly Asp Thr Pro Ile Asp 
        435                 440                 445             


Thr Phe Leu Met Glu Met Leu Glu Ala Pro His Gln Met Thr 
    450                 455                 460         


<210>  3
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  PHOSPHORYLATION

<400>  3

Ser Pro Ile Ser Thr Leu Ser Ser Pro Ile Asn Gly 
1               5                   10          


<210>  4
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  4

Ser Pro Ile Ser Thr Leu Ser Ser Pro Ile Asn Gly 
1               5                   10          


