                         SEQUENCE LISTING

<110>  The University of British Columbia
 
<120>  CAMPTOTHECIN HYROXYLASES AND USES THEREOF

<130>  V817531WO

<150>  US 63/123,678
<151>  2020-12-10

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  1539
<212>  DNA
<213>  Camptotheca acuminata

<400>  1
atggagaact tgtactactg ccttgctctc ctactatcaa ttcttttcat attcagacat       60

ttcttccgtc atagttcaaa gttaccacca agtccgtttg cccttcctat catcggccat      120

ctccatctca tcaggaattc tttgcaccaa gtactagagt gcttggcatc tcaatatggt      180

ccaattttat ttctcaaatt tggcacccgc tctattcttg ttgtgtcttc tccatccgct      240

gttgaggaat gcctcattaa gaatgatatt atatttgcaa accgtcctcg gagcatgatt      300

ttagatctct ctagttttaa ttatagtata ttttcatggg ctccatatgg tcattactgg      360

cgaagcctcc gccgccttgc tgttgttgaa ctcttcacat cgcgcagcct tcagacgtct      420

tccaacatcc gtaaagagga aattcataac cttctctgtc acctcttcaa attctcaaaa      480

agtggaactc aaaaactcca gttgaaatat tggttctctc tattgacatt caatattata      540

acaaggctgg tagctgggaa gcggtgtgtt agagatgcag ttgcaggcac ggattcgggt      600

aaacaaattc ttgaagacct cgaggggaag ttcacttcaa aaatgccatt taatatgtgt      660

gatttctttc caattttgag gtggtttggt tacaaagggt tggagaaaat tctgattacg      720

ttgcacaagg agagagatga attcatgcaa ggtttgatag atgaggttag acgaaagaga      780

acatgttctg ccaatatcaa tagtgtaaca aacagagcaa agacaacatt gattgaagct      840

ctcttgtccc tccaagaatc agaacctgac ttcttttctg atactatcat caaaagtatc      900

atttcagaca tgttttttgc agggccagaa acatcaacaa tcactttaga atgggcaatg      960

tcacttcttc taaatcatcc agaggtattg ggaaagttga gagcagagat tgatgatcat     1020

gttggacatg gacgccttct agatgactcg gatcttggga agcttcccta tctccgttgc     1080

atcatcaatg agaccctcag attatatcct ccaacaccac ttctattacc acactgttca     1140

tctgaagatt gcattgtggg gggatatgaa ataccacaag gtacaatcct gtgggtgaat     1200

gcttgggcca tgcatagaga tcccaagttg tgggaggagc caaccaagtt caagcctgag     1260

agatttgaag gcatggaagg gagagaaagg tataaattta tgccatttgg aattgggaga     1320

agagcttgtc caggtgctag tatggccatc cggacagttt cattggcatt gggtgcactt     1380

attcaatgtt ttgaatggga aaacgttggg ccggataaaa gggagatgag ccagggtcga     1440

cttactttgc ccaaggccga gtctttggag gctgtgtcta ttccacgccc cagtgcagtg     1500

aaagtcctct cccagcttga aggcacttgt ttccgttag                            1539


<210>  2
<211>  1539
<212>  DNA
<213>  Camptotheca acuminata

<400>  2
atggagaact tgtactactg ccttgctctc ctactatcaa ttcttttcat attcagacat       60

ttcttccatc atagttcaaa gttaccacca agtccatttg cctttcctat catcggccat      120

ctccatctca tcaggaattc tttccaccaa gtactagagt gcttggcatc tcaatatggt      180

ccaattttat tcctcaaatt tggcatccgc tctattcttg ttgtgtcatc accatccgtt      240

gttgaggaat gttttattaa gaatgatatt atatttgcaa accgtcctcg gaatatgctt      300

tcagatatct ctagttataa ttatagtacg atcgtagggg ctccatatgg tcattactgg      360

cggagcctcc gccgccttgc tagtgttgaa ttcttctcat tgaatagcct ccagaagtct      420

tctaacatcc gtgaagagga aattcataac cttctctatc acctcttcaa attctcaaaa      480

agtggaactc aaaaagtcca gttgaaatat tggttctctc tattgacatt caatataata      540

acgaggctgg tagctgggaa gcggtgtgtt agagatgcgg ttgcaggcat ggatttgggg      600

aaacaaattc ttgaagaact caaggggaag ttcgtttcga tcatgccatt gaatatgtgt      660

gatttctttc caattttgag gtggtttggt tacaaagggc tggagaaaaa tctgattacg      720

ttgcacaagg agagagatga attcttgcag gacttgataa atgaggttag acgaaagaga      780

acatgttctg ccaatatcaa tattgtaaca aacaaagcaa agacaacatt gattggaact      840

ctcttgtcct tccaagaatc agaacctgac ttcttttctg atactatcat caaaagtatc      900

atttcagaca tgttttttgc aggatcagaa acatcagcaa tcactctaga atgggcaatg      960

tcacttcttc taaatcatcc agaggtattg ggaaagttga gagcagagat tgatgatcat     1020

gttggacatg gacgccttct agatgactcg gatcttgtga agcttcccta tcttcgttgc     1080

atcatcaatg aaaccctcag attatatcct ccaacaccac ttctattacc tcactgttca     1140

tctgtagatt gcactgtggg gggatatgaa ataccacaag gtacaatcct gtgggtgaat     1200

gcttgggcca tgcatagaga tcccaagtta tgggaggagc caaccaagtt caagcctgag     1260

agatttgaag gcatggaagg gagagaaagg tacaaattta ttccatttgg aattgggaga     1320

agagcttgtc caggtgctag tatgggcatc cggacagttt cattggcttt gggcgcactt     1380

attcagtgtt ttcaatggga aaacgttggg caggataaaa gggagatgag tccggttcga     1440

cttacgttgc ccaaggccga gtctttggag gctatgtgta ttccacgccc cagtgcaatg     1500

aaagtcctct cccagcttga agacacttgt ttcagttag                            1539


<210>  3
<211>  511
<212>  PRT
<213>  Camptotheca acuminata

<400>  3

Met Glu Asn Leu Tyr Tyr Cys Leu Ala Leu Leu Leu Ser Ile Leu Phe 
1               5                   10                  15      


Ile Phe Arg His Phe Phe Arg His Ser Ser Lys Leu Pro Pro Ser Pro 
            20                  25                  30          


Phe Ala Leu Pro Ile Ile Gly His Leu His Leu Ile Arg Asn Ser Leu 
        35                  40                  45              


His Gln Val Leu Glu Cys Leu Ala Ser Gln Tyr Gly Pro Ile Leu Phe 
    50                  55                  60                  


Leu Lys Phe Gly Thr Arg Ser Ile Leu Val Val Ser Ser Pro Ser Ala 
65                  70                  75                  80  


Val Glu Glu Cys Leu Ile Lys Asn Asp Ile Ile Phe Ala Asn Arg Pro 
                85                  90                  95      


Arg Ser Met Ile Leu Asp Leu Ser Ser Phe Asn Tyr Ser Ile Phe Ser 
            100                 105                 110         


Trp Ala Pro Tyr Gly His Tyr Trp Arg Ser Leu Arg Arg Leu Ala Val 
        115                 120                 125             


Val Glu Leu Phe Thr Ser Arg Ser Leu Gln Thr Ser Ser Asn Ile Arg 
    130                 135                 140                 


Lys Glu Glu Ile His Asn Leu Leu Cys His Leu Phe Lys Phe Ser Lys 
145                 150                 155                 160 


Ser Gly Thr Gln Lys Leu Gln Leu Lys Tyr Trp Phe Ser Leu Leu Thr 
                165                 170                 175     


Phe Asn Ile Ile Thr Arg Leu Val Ala Gly Lys Arg Cys Val Arg Asp 
            180                 185                 190         


Ala Val Ala Gly Thr Asp Ser Gly Lys Gln Ile Leu Glu Asp Leu Glu 
        195                 200                 205             


Gly Lys Phe Thr Ser Lys Met Pro Phe Asn Met Cys Asp Phe Phe Pro 
    210                 215                 220                 


Ile Leu Arg Trp Phe Gly Tyr Lys Gly Leu Glu Lys Ile Leu Ile Thr 
225                 230                 235                 240 


Leu His Lys Glu Arg Asp Glu Phe Met Gln Gly Leu Ile Asp Glu Val 
                245                 250                 255     


Arg Arg Lys Arg Thr Cys Ser Ala Asn Ile Asn Ser Val Thr Asn Arg 
            260                 265                 270         


Ala Lys Thr Thr Leu Ile Glu Ala Leu Leu Ser Leu Gln Glu Ser Glu 
        275                 280                 285             


Pro Asp Phe Phe Ser Asp Thr Ile Ile Lys Ser Ile Ile Ser Asp Met 
    290                 295                 300                 


Phe Phe Ala Gly Pro Glu Thr Ser Thr Ile Thr Leu Glu Trp Ala Met 
305                 310                 315                 320 


Ser Leu Leu Leu Asn His Pro Glu Val Leu Gly Lys Leu Arg Ala Glu 
                325                 330                 335     


Ile Asp Asp His Val Gly His Gly Arg Leu Leu Asp Asp Ser Asp Leu 
            340                 345                 350         


Gly Lys Leu Pro Tyr Leu Arg Cys Ile Ile Asn Glu Thr Leu Arg Leu 
        355                 360                 365             


Tyr Pro Pro Thr Pro Leu Leu Leu Pro His Cys Ser Ser Glu Asp Cys 
    370                 375                 380                 


Ile Val Gly Gly Tyr Glu Ile Pro Gln Gly Thr Ile Leu Trp Val Asn 
385                 390                 395                 400 


Ala Trp Ala Met His Arg Asp Pro Lys Leu Trp Glu Glu Pro Thr Lys 
                405                 410                 415     


Phe Lys Pro Glu Arg Phe Glu Gly Met Glu Gly Arg Glu Arg Tyr Lys 
            420                 425                 430         


Phe Met Pro Phe Gly Ile Gly Arg Arg Ala Cys Pro Gly Ala Ser Met 
        435                 440                 445             


Ala Ile Arg Thr Val Ser Leu Ala Leu Gly Ala Leu Ile Gln Cys Phe 
    450                 455                 460                 


Glu Trp Glu Asn Val Gly Pro Asp Lys Arg Glu Met Ser Gln Gly Arg 
465                 470                 475                 480 


Leu Thr Leu Pro Lys Ala Glu Ser Leu Glu Ala Val Ser Ile Pro Arg 
                485                 490                 495     


Pro Ser Ala Val Lys Val Leu Ser Gln Leu Glu Gly Thr Cys Phe 
            500                 505                 510     


<210>  4
<211>  512
<212>  PRT
<213>  Camptotheca acuminata

<400>  4

Met Glu Asn Leu Tyr Tyr Cys Leu Ala Leu Leu Leu Ser Ile Leu Phe 
1               5                   10                  15      


Ile Phe Arg His Phe Phe His His Ser Ser Lys Leu Pro Pro Ser Pro 
            20                  25                  30          


Phe Ala Phe Pro Ile Ile Gly His Leu His Leu Ile Arg Asn Ser Phe 
        35                  40                  45              


His Gln Val Leu Glu Cys Leu Ala Ser Gln Tyr Gly Pro Ile Leu Phe 
    50                  55                  60                  


Leu Lys Phe Gly Ile Arg Ser Ile Leu Val Val Ser Ser Pro Ser Val 
65                  70                  75                  80  


Val Glu Glu Cys Phe Ile Lys Asn Asp Ile Ile Phe Ala Asn Arg Pro 
                85                  90                  95      


Arg Asn Met Leu Ser Asp Ile Ser Ser Tyr Asn Tyr Ser Thr Ile Val 
            100                 105                 110         


Gly Ala Pro Tyr Gly His Tyr Trp Arg Ser Leu Arg Arg Leu Ala Ser 
        115                 120                 125             


Val Glu Phe Phe Ser Leu Asn Ser Leu Gln Lys Ser Ser Asn Ile Arg 
    130                 135                 140                 


Glu Glu Glu Ile His Asn Leu Leu Tyr His Leu Phe Lys Phe Ser Lys 
145                 150                 155                 160 


Ser Gly Thr Gln Lys Val Gln Leu Lys Tyr Trp Phe Ser Leu Leu Thr 
                165                 170                 175     


Phe Asn Ile Ile Thr Arg Leu Val Ala Gly Lys Arg Cys Val Arg Asp 
            180                 185                 190         


Ala Val Ala Gly Met Asp Leu Gly Lys Gln Ile Leu Glu Glu Leu Lys 
        195                 200                 205             


Gly Lys Phe Val Ser Ile Met Pro Leu Asn Met Cys Asp Phe Phe Pro 
    210                 215                 220                 


Ile Leu Arg Trp Phe Gly Tyr Lys Gly Leu Glu Lys Asn Leu Ile Thr 
225                 230                 235                 240 


Leu His Lys Glu Arg Asp Glu Phe Leu Gln Asp Leu Ile Asn Glu Val 
                245                 250                 255     


Arg Arg Lys Arg Thr Cys Ser Ala Asn Ile Asn Ile Val Thr Asn Lys 
            260                 265                 270         


Ala Lys Thr Thr Leu Ile Gly Thr Leu Leu Ser Phe Gln Glu Ser Glu 
        275                 280                 285             


Pro Asp Phe Phe Ser Asp Thr Ile Ile Lys Ser Ile Ile Ser Asp Met 
    290                 295                 300                 


Phe Phe Ala Gly Ser Glu Thr Ser Ala Ile Thr Leu Glu Trp Ala Met 
305                 310                 315                 320 


Ser Leu Leu Leu Asn His Pro Glu Val Leu Gly Lys Leu Arg Ala Glu 
                325                 330                 335     


Ile Asp Asp His Val Gly His Gly Arg Leu Leu Asp Asp Ser Asp Leu 
            340                 345                 350         


Val Lys Leu Pro Tyr Leu Arg Cys Ile Ile Asn Glu Thr Leu Arg Leu 
        355                 360                 365             


Tyr Pro Pro Thr Pro Leu Leu Leu Pro His Cys Ser Ser Val Asp Cys 
    370                 375                 380                 


Thr Val Gly Gly Tyr Glu Ile Pro Gln Gly Thr Ile Leu Trp Val Asn 
385                 390                 395                 400 


Ala Trp Ala Met His Arg Asp Pro Lys Leu Trp Glu Glu Pro Thr Lys 
                405                 410                 415     


Phe Lys Pro Glu Arg Phe Glu Gly Met Glu Gly Arg Glu Arg Tyr Lys 
            420                 425                 430         


Phe Ile Pro Phe Gly Ile Gly Arg Arg Ala Cys Pro Gly Ala Ser Met 
        435                 440                 445             


Gly Ile Arg Thr Val Ser Leu Ala Leu Gly Ala Leu Ile Gln Cys Phe 
    450                 455                 460                 


Gln Trp Glu Asn Val Gly Gln Asp Lys Arg Glu Met Ser Pro Val Arg 
465                 470                 475                 480 


Leu Thr Leu Pro Lys Ala Glu Ser Leu Glu Ala Met Cys Ile Pro Arg 
                485                 490                 495     


Pro Ser Ala Met Lys Val Leu Ser Gln Leu Glu Asp Thr Cys Phe Ser 
            500                 505                 510         


<210>  5
<211>  1557
<212>  DNA
<213>  Ophiorrhiza pumila

<400>  5
atggagaatc tctactatta cttagtgtca atcttcttgt gtggtgtttt cctgattcta       60

tccaaacaat tgttgttcaa caagaacaag aagttacctc ctagtcctcg tgttcttcca      120

ataattggcc atctccatct catcaagaac gaattctatg aagattttac ttcattatca      180

tctacatacg gtccagtttt ctttctccga tttggctgcc ggtcctatgt tgttgtgtct      240

tctccatctg ctgttggaga gtgtttcaca aagaatgata ttatacttgc aaaccgtcct      300

aagaccatgg ctggggacag gttgacctat aactatggat catttggagt ggctccttat      360

ggggatatat ggagggttct tcgtcgcctc actgttgttg aatctttatc tttcaacagc      420

ctccaaaagt cctcaaatat cagggaagaa gaaattcaga tgattgttcg ttcactctat      480

cgagtctcaa agaatggaag ccaacgagtt gatttgaact attggatttc agtttttaca      540

ctcaatgtta ttatgaggat ggttactgga agatgctcaa ttagagagga agatgctgga      600

gacgagttgg ggaagcaaat agttaaagaa ttcaaagaca actttgctac agccctttca      660

atgagcttgt gcgacttctt cccgatatta aggtggtttg gttacaaagg gctggaaaag      720

agaatgatca ttttgcacaa gaagagagat gcattccttc agggtttagt agatgaactt      780

cgatcaaata aatctaattt ttctccttcc ggcactggaa tgaacgaaga gaagaagaag      840

gcattaattc aatccctcct ttctcatcag gaactagaac ctgattttct caaagatgac      900

tctataaaga gtattgcatt gtccatcttt ctagcaggaa gagaaacgtc atccatgacc      960

attgaatggg ctatgtcact cttactgaat caccaggaag caatgcagaa gttaaggact     1020

gaaatcgaca acaacgtagg acacaaaaga ttgttggatg aatcggatat tccaaagctt     1080

ccttatctgc gttgtgtagt ggatgagacg atgagactgt atcctgcagc accactgctt     1140

cttcctcatt atgcgtctga aaattgtaga gtttgtgact atgacattcc aaaaggtacg     1200

actgttttaa ctaatgcttg ggccatacac agggatccaa aactctggga tatgcctgaa     1260

aagttcatgc cagagagatt tgaggctaaa caaatagggg gaaaagaaga gttcaatttc     1320

aagtttctac catttgggat agggaggaga gcatgtcccg gagccaattt ggccattcgg     1380

aacgtttctt tggcattggg tgcattgtta cagtgctttt attgggaaaa agttggagag     1440

aaggaaggcg atatggacag taagaacgat gatagagtca ctttgcagaa ggccaaaccc     1500

ttggaggcca tttgttttcc acgccaagaa tcaatccaac ttctctcgca actctga        1557


<210>  6
<211>  1443
<212>  DNA
<213>  Ophiorrhiza pumila

<400>  6
atgtcaaccc gagttctttg ggataagatt cctatcagac taagagtttt aatcctactg       60

caactctacc agacttcatc agttttcttt ctccgatttg gctgccggtc ctatgttgtt      120

gtgtcttctc catctgctgt tggagagtgt ttcacaaaga atgatattat acttgcaaac      180

cgtcctaaga ccatggctgg ggacaggttg acctataact atggatcatt tggagtggct      240

ccgtatgggg atatatggag ggttcttcgt cgcctcactg ttgttgaatc tttatctttc      300

aacagcctcc aaaagtcctc taatatcagg gaagaagaaa ttcagatgat tgttcgttca      360

ctctatcgag tctcaaagaa tggaagccaa cgagttgatt tgaactattg gatttcagtt      420

tttacactca atgttattat gaggatggtt actggaagat gctcaattag agaggaagat      480

gctggagacg agttggggaa gcaaatagtt aaagaattca aagacaactt tgctacagcc      540

ctttcaatga gcttgtgcga cttcttcccg atattaaggt ggtttggtta caaagggctg      600

gaaaagagaa tgatcatttt gcacaagaag agagatgcat tccttcaggg tttagtagat      660

gaacttcgat caaataaatc taatttttct ccttccggca ctggaatgaa cgaagagaag      720

aagaaggcat taattcaatc cctcctttct catcaggaac tagaacctga ttttctcaaa      780

gatgactcta taaagagtat tgcattgtcc atctttctag caggaagaga aacgtcatcc      840

atgaccattg aatgggctat gtcactctta ctgaatcacc aggaagcaat gcagaagtta      900

aggactgaaa tcgacaacaa cgtaggacac aaaagattgt tggatgaatc ggatattcca      960

aagcttcctt atctgcgttg tgtagtggat gagacgatga gactgtatcc tgcagcacca     1020

ctgcttcttc ctcattatgc gtctgaaaat tgtagagttt gtgactatga cattccaaaa     1080

ggtacgactg ttttaactaa tgcttgggcc atacacaggg atccaaaact ctgggatatg     1140

cctgaaaagt tcatgccaga gagatttgag gctaaacaaa tagggggaaa agaagagttc     1200

aatttcaagt ttctaccatt tgggataggg aggagagcat gtcccggagc caatttggcc     1260

attcggaacg tttctttggc attgggtgca ttgttacagt gcttttattg ggaaaaagtt     1320

ggagagaagg aaggcgatat ggacagtaag aacgatgata gagtcacttt gcagaaggcc     1380

aaacccttgg aggccatttg ttttccacgc caagaatcaa tccaacttct ctcgcaactc     1440

tga                                                                   1443


<210>  7
<211>  3042
<212>  DNA
<213>  Ophiorrhiza pumila

<400>  7
atggagaatc tctactacta cttagtgtca atcttcttgt gtggtttttt cctgatccta       60

tccaaacaat tgtttttcaa caagaacaag aagttacctc ctagtcctcg tgctcttcca      120

ataattggcc atctccatct catcaagaac gaactctatg aagattttac ttcattatca      180

tctacatacg gtccagtttt ctttctccga tttggctgcc ggtcctatgt tgttgtgtct      240

tctccatctg ctgttgaaga gtgtttcaca aagaatgata ttatacttgc aaaccgtgat      300

aagaccatgg ctggggacag gttgacctat aactatggaa catttgcaat ggctccttat      360

ggggatatat ggagggttct tcgtcgcctc actgttgttg aatctttatc tttcaacaga      420

ctccaaaagt cctcaaatat cagggaagaa gaaattcaga tgattgttcg ttcactcttt      480

cgagtctcaa agaatggaag ccaacgagtt gatttgaact attggatttc agtttttaca      540

ctcaatgtta ttatgaggat ggttactgga agatgctcaa ttagagagga agatgctgga      600

gacgagttgg ggaagcaaat agttaaagaa ttcaaagaca actttgctac aggcctttca      660

atgaacttgt gcgacttctt cccgatatta aggtggtttg gttacaaagg gctggaaaag      720

agaatgatca ttttgcacaa gaagagagat gcattccttc agggtttagt agatgaactt      780

cgatcaaata aatctaattt ttctccttcc ggcactggaa tgaacgaaga gaagaagaag      840

gcattaattg aatccctcct ttctcatcag gaactagaac ctgattttct caaagatgac      900

tctataaaga gtattgcatt gtccatcttt atagcaggaa gagaaacatc atccatgacc      960

attgaatggg ctatgtcact cttactgaat cacccggaag caatgcacaa gttaaggact     1020

gaaatcgaca acaacgtagg acacaaaaga ttgttggatg aatcggatat tccaaagctt     1080

ccttatctgc gttgtgtcgt ggatgagaca ttgagactgt atcctccagc accactgctt     1140

ctacctcatt atgcatctga aaattgtaga gtttgggact atgacattcc aaaaggtacg     1200

actgttttag ctaatgcttg ggccatacac agggatccaa aactctggga tatgcctgaa     1260

aagttcatgc cagagagatt tgaggctaaa caattagggg aaaaagaaga gttcaatttc     1320

aagtttctac catttgggat agggaggaga gcatgtcccg gagccaattt gggcattcgg     1380

aacgtttctt tggcattggg tgcattgtta cagtgctttt attgggaaaa agttggagag     1440

aaggaaggcg atatggacat gatagtggat agagccatag agttctattt tgccatggag     1500

aatctctact actacttagt ctcaatcttt ttgtgttgct ttttcgtgat cctattccta     1560

tccaaacaat tgctgttcaa caagaacaag aagttgccac ccagtcctcc tgctcttcca     1620

ataattggcc atctccatct catcaagaac gaactctatc gagatttaac ttcattatca     1680

tctacatacg gtccagtttt ctttctcaaa tttggttgcc ggtcctatgt tgttgtgtct     1740

tctccatctg ccgttgaaga gtgcttcaca aagaatgata atatacttgc aaaccgtcct     1800

aacaccatgg cttcggacat ttttacctat aactactcaa caattggatc ggctccttat     1860

gggaatttat ggagggttct tcgtcgcctc actgttgctg aatctttatc atccaacagc     1920

cttcagaagt cctcaaatat cagggaagaa gaaattcaga tgattgttcg ttcactcttt     1980

cgaatctcaa agaatggaag ccaacgagtt gatttgaact actggatttc agtttttaca     2040

ctcaatatta ttacgaggat gattactgga agatgctcaa ttagagagga ggatgccgga     2100

gatgagttgg ggaagcaaat agctaaagaa ttcaaagata ggtttgcttc aggcactgca     2160

atgaacttgt gcgacttctt tccgatatta aggtggtttg gttacaaagg gttggaaaag     2220

aaaatgatca gtttgtacaa gaagagagat gcattccttc agggtttagt agataaattt     2280

cgatcagata aatctaacaa cgaagagaag aagaagacca taattgaatc tctcctctct     2340

catcaggaag aactagaact aaagcctgat tttctctcag atggcttaat aaagagtact     2400

gcgctgtcca tctttatagc aggaagagaa acatcatccc tgaccattga atgggctatg     2460

tcactcttac tgaaacaccc gaaagcaatg cacaagttaa ggactgaaat cgacaacaat     2520

gtaggacaca aaagattgtt ggatgaatcg gatattccaa agcttcctta tctgcgttgt     2580

gtcgtggatg agacattgag actgtatcct ccagcaccac tgcttctacc tcattatgca     2640

tctgaaaatt gtagagtttg ggactatgac attccaaaag gtacgactgt tttagctaac     2700

gcttgggcca tacacaggga tccaaaactc tgggatatgc ctgaaaagtt catgccagag     2760

agatttgagg ctaaacaatt aggggaaaaa gaagagttca atttcaagtt tctaccattt     2820

gggataggga ggagagcatg tcccggagcc aatttgggca ttcggaacgt ttctttggca     2880

ttgggtgcat tgttacagtg cttttattgg gacaaagttg gagaaaagga aggtgatatg     2940

gacactaaca acgacgataa actcactttg cataaggcca aaccctgcga ggccatgtgt     3000

tttccacgcc aagaatcaat ccaacttctc tcgcaactct ga                        3042


<210>  8
<211>  518
<212>  PRT
<213>  Ophiorrhiza pumila

<400>  8

Met Glu Asn Leu Tyr Tyr Tyr Leu Val Ser Ile Phe Leu Cys Gly Val 
1               5                   10                  15      


Phe Leu Ile Leu Ser Lys Gln Leu Leu Phe Asn Lys Asn Lys Lys Leu 
            20                  25                  30          


Pro Pro Ser Pro Arg Val Leu Pro Ile Ile Gly His Leu His Leu Ile 
        35                  40                  45              


Lys Asn Glu Phe Tyr Glu Asp Phe Thr Ser Leu Ser Ser Thr Tyr Gly 
    50                  55                  60                  


Pro Val Phe Phe Leu Arg Phe Gly Cys Arg Ser Tyr Val Val Val Ser 
65                  70                  75                  80  


Ser Pro Ser Ala Val Gly Glu Cys Phe Thr Lys Asn Asp Ile Ile Leu 
                85                  90                  95      


Ala Asn Arg Pro Lys Thr Met Ala Gly Asp Arg Leu Thr Tyr Asn Tyr 
            100                 105                 110         


Gly Ser Phe Gly Val Ala Pro Tyr Gly Asp Ile Trp Arg Val Leu Arg 
        115                 120                 125             


Arg Leu Thr Val Val Glu Ser Leu Ser Phe Asn Ser Leu Gln Lys Ser 
    130                 135                 140                 


Ser Asn Ile Arg Glu Glu Glu Ile Gln Met Ile Val Arg Ser Leu Tyr 
145                 150                 155                 160 


Arg Val Ser Lys Asn Gly Ser Gln Arg Val Asp Leu Asn Tyr Trp Ile 
                165                 170                 175     


Ser Val Phe Thr Leu Asn Val Ile Met Arg Met Val Thr Gly Arg Cys 
            180                 185                 190         


Ser Ile Arg Glu Glu Asp Ala Gly Asp Glu Leu Gly Lys Gln Ile Val 
        195                 200                 205             


Lys Glu Phe Lys Asp Asn Phe Ala Thr Ala Leu Ser Met Ser Leu Cys 
    210                 215                 220                 


Asp Phe Phe Pro Ile Leu Arg Trp Phe Gly Tyr Lys Gly Leu Glu Lys 
225                 230                 235                 240 


Arg Met Ile Ile Leu His Lys Lys Arg Asp Ala Phe Leu Gln Gly Leu 
                245                 250                 255     


Val Asp Glu Leu Arg Ser Asn Lys Ser Asn Phe Ser Pro Ser Gly Thr 
            260                 265                 270         


Gly Met Asn Glu Glu Lys Lys Lys Ala Leu Ile Gln Ser Leu Leu Ser 
        275                 280                 285             


His Gln Glu Leu Glu Pro Asp Phe Leu Lys Asp Asp Ser Ile Lys Ser 
    290                 295                 300                 


Ile Ala Leu Ser Ile Phe Leu Ala Gly Arg Glu Thr Ser Ser Met Thr 
305                 310                 315                 320 


Ile Glu Trp Ala Met Ser Leu Leu Leu Asn His Gln Glu Ala Met Gln 
                325                 330                 335     


Lys Leu Arg Thr Glu Ile Asp Asn Asn Val Gly His Lys Arg Leu Leu 
            340                 345                 350         


Asp Glu Ser Asp Ile Pro Lys Leu Pro Tyr Leu Arg Cys Val Val Asp 
        355                 360                 365             


Glu Thr Met Arg Leu Tyr Pro Ala Ala Pro Leu Leu Leu Pro His Tyr 
    370                 375                 380                 


Ala Ser Glu Asn Cys Arg Val Cys Asp Tyr Asp Ile Pro Lys Gly Thr 
385                 390                 395                 400 


Thr Val Leu Thr Asn Ala Trp Ala Ile His Arg Asp Pro Lys Leu Trp 
                405                 410                 415     


Asp Met Pro Glu Lys Phe Met Pro Glu Arg Phe Glu Ala Lys Gln Ile 
            420                 425                 430         


Gly Gly Lys Glu Glu Phe Asn Phe Lys Phe Leu Pro Phe Gly Ile Gly 
        435                 440                 445             


Arg Arg Ala Cys Pro Gly Ala Asn Leu Ala Ile Arg Asn Val Ser Leu 
    450                 455                 460                 


Ala Leu Gly Ala Leu Leu Gln Cys Phe Tyr Trp Glu Lys Val Gly Glu 
465                 470                 475                 480 


Lys Glu Gly Asp Met Asp Ser Lys Asn Asp Asp Arg Val Thr Leu Gln 
                485                 490                 495     


Lys Ala Lys Pro Leu Glu Ala Ile Cys Phe Pro Arg Gln Glu Ser Ile 
            500                 505                 510         


Gln Leu Leu Ser Gln Leu 
        515             


<210>  9
<211>  480
<212>  PRT
<213>  Ophiorrhiza pumila

<400>  9

Met Ser Thr Arg Val Leu Trp Asp Lys Ile Pro Ile Arg Leu Arg Val 
1               5                   10                  15      


Leu Ile Leu Leu Gln Leu Tyr Gln Thr Ser Ser Val Phe Phe Leu Arg 
            20                  25                  30          


Phe Gly Cys Arg Ser Tyr Val Val Val Ser Ser Pro Ser Ala Val Gly 
        35                  40                  45              


Glu Cys Phe Thr Lys Asn Asp Ile Ile Leu Ala Asn Arg Pro Lys Thr 
    50                  55                  60                  


Met Ala Gly Asp Arg Leu Thr Tyr Asn Tyr Gly Ser Phe Gly Val Ala 
65                  70                  75                  80  


Pro Tyr Gly Asp Ile Trp Arg Val Leu Arg Arg Leu Thr Val Val Glu 
                85                  90                  95      


Ser Leu Ser Phe Asn Ser Leu Gln Lys Ser Ser Asn Ile Arg Glu Glu 
            100                 105                 110         


Glu Ile Gln Met Ile Val Arg Ser Leu Tyr Arg Val Ser Lys Asn Gly 
        115                 120                 125             


Ser Gln Arg Val Asp Leu Asn Tyr Trp Ile Ser Val Phe Thr Leu Asn 
    130                 135                 140                 


Val Ile Met Arg Met Val Thr Gly Arg Cys Ser Ile Arg Glu Glu Asp 
145                 150                 155                 160 


Ala Gly Asp Glu Leu Gly Lys Gln Ile Val Lys Glu Phe Lys Asp Asn 
                165                 170                 175     


Phe Ala Thr Ala Leu Ser Met Ser Leu Cys Asp Phe Phe Pro Ile Leu 
            180                 185                 190         


Arg Trp Phe Gly Tyr Lys Gly Leu Glu Lys Arg Met Ile Ile Leu His 
        195                 200                 205             


Lys Lys Arg Asp Ala Phe Leu Gln Gly Leu Val Asp Glu Leu Arg Ser 
    210                 215                 220                 


Asn Lys Ser Asn Phe Ser Pro Ser Gly Thr Gly Met Asn Glu Glu Lys 
225                 230                 235                 240 


Lys Lys Ala Leu Ile Gln Ser Leu Leu Ser His Gln Glu Leu Glu Pro 
                245                 250                 255     


Asp Phe Leu Lys Asp Asp Ser Ile Lys Ser Ile Ala Leu Ser Ile Phe 
            260                 265                 270         


Leu Ala Gly Arg Glu Thr Ser Ser Met Thr Ile Glu Trp Ala Met Ser 
        275                 280                 285             


Leu Leu Leu Asn His Gln Glu Ala Met Gln Lys Leu Arg Thr Glu Ile 
    290                 295                 300                 


Asp Asn Asn Val Gly His Lys Arg Leu Leu Asp Glu Ser Asp Ile Pro 
305                 310                 315                 320 


Lys Leu Pro Tyr Leu Arg Cys Val Val Asp Glu Thr Met Arg Leu Tyr 
                325                 330                 335     


Pro Ala Ala Pro Leu Leu Leu Pro His Tyr Ala Ser Glu Asn Cys Arg 
            340                 345                 350         


Val Cys Asp Tyr Asp Ile Pro Lys Gly Thr Thr Val Leu Thr Asn Ala 
        355                 360                 365             


Trp Ala Ile His Arg Asp Pro Lys Leu Trp Asp Met Pro Glu Lys Phe 
    370                 375                 380                 


Met Pro Glu Arg Phe Glu Ala Lys Gln Ile Gly Gly Lys Glu Glu Phe 
385                 390                 395                 400 


Asn Phe Lys Phe Leu Pro Phe Gly Ile Gly Arg Arg Ala Cys Pro Gly 
                405                 410                 415     


Ala Asn Leu Ala Ile Arg Asn Val Ser Leu Ala Leu Gly Ala Leu Leu 
            420                 425                 430         


Gln Cys Phe Tyr Trp Glu Lys Val Gly Glu Lys Glu Gly Asp Met Asp 
        435                 440                 445             


Ser Lys Asn Asp Asp Arg Val Thr Leu Gln Lys Ala Lys Pro Leu Glu 
    450                 455                 460                 


Ala Ile Cys Phe Pro Arg Gln Glu Ser Ile Gln Leu Leu Ser Gln Leu 
465                 470                 475                 480 


<210>  10
<211>  515
<212>  PRT
<213>  Ophiorrhiza pumila

<400>  10

Met Glu Asn Leu Tyr Tyr Tyr Leu Val Ser Ile Phe Leu Cys Cys Phe 
1               5                   10                  15      


Phe Val Ile Leu Phe Leu Ser Lys Gln Leu Leu Phe Asn Lys Asn Lys 
            20                  25                  30          


Lys Leu Pro Pro Ser Pro Pro Ala Leu Pro Ile Ile Gly His Leu His 
        35                  40                  45              


Leu Ile Lys Asn Glu Leu Tyr Arg Asp Leu Thr Ser Leu Ser Ser Thr 
    50                  55                  60                  


Tyr Gly Pro Val Phe Phe Leu Lys Phe Gly Cys Arg Ser Tyr Val Val 
65                  70                  75                  80  


Val Ser Ser Pro Ser Ala Val Glu Glu Cys Phe Thr Lys Asn Asp Asn 
                85                  90                  95      


Ile Leu Ala Asn Arg Pro Asn Thr Met Ala Ser Asp Ile Phe Thr Tyr 
            100                 105                 110         


Asn Tyr Ser Thr Ile Gly Ser Ala Pro Tyr Gly Asn Leu Trp Arg Val 
        115                 120                 125             


Leu Arg Arg Leu Thr Val Ala Glu Ser Leu Ser Ser Asn Ser Leu Gln 
    130                 135                 140                 


Lys Ser Ser Asn Ile Arg Glu Glu Glu Ile Gln Met Ile Val Arg Ser 
145                 150                 155                 160 


Leu Phe Arg Ile Ser Lys Asn Gly Ser Gln Arg Val Asp Leu Asn Tyr 
                165                 170                 175     


Trp Ile Ser Val Phe Thr Leu Asn Ile Ile Thr Arg Met Ile Thr Gly 
            180                 185                 190         


Arg Cys Ser Ile Arg Glu Glu Asp Ala Gly Asp Glu Leu Gly Lys Gln 
        195                 200                 205             


Ile Ala Lys Glu Phe Lys Asp Arg Phe Ala Ser Gly Thr Ala Met Asn 
    210                 215                 220                 


Leu Cys Asp Phe Phe Pro Ile Leu Arg Trp Phe Gly Tyr Lys Gly Leu 
225                 230                 235                 240 


Glu Lys Lys Met Ile Ser Leu Tyr Lys Lys Arg Asp Ala Phe Leu Gln 
                245                 250                 255     


Gly Leu Val Asp Lys Phe Arg Ser Asp Lys Ser Asn Asn Glu Glu Lys 
            260                 265                 270         


Lys Lys Thr Ile Ile Glu Ser Leu Leu Ser His Gln Glu Glu Leu Glu 
        275                 280                 285             


Leu Lys Pro Asp Phe Leu Ser Asp Gly Leu Ile Lys Ser Thr Ala Leu 
    290                 295                 300                 


Ser Ile Phe Ile Ala Gly Arg Glu Thr Ser Ser Leu Thr Ile Glu Trp 
305                 310                 315                 320 


Ala Met Ser Leu Leu Leu Lys His Pro Lys Ala Met His Lys Leu Arg 
                325                 330                 335     


Thr Glu Ile Asp Asn Asn Val Gly His Lys Arg Leu Leu Asp Glu Ser 
            340                 345                 350         


Asp Ile Pro Lys Leu Pro Tyr Leu Arg Cys Val Val Asp Glu Thr Leu 
        355                 360                 365             


Arg Leu Tyr Pro Pro Ala Pro Leu Leu Leu Pro His Tyr Ala Ser Glu 
    370                 375                 380                 


Asn Cys Arg Val Trp Asp Tyr Asp Ile Pro Lys Gly Thr Thr Val Leu 
385                 390                 395                 400 


Ala Asn Ala Trp Ala Ile His Arg Asp Pro Lys Leu Trp Asp Met Pro 
                405                 410                 415     


Glu Lys Phe Met Pro Glu Arg Phe Glu Ala Lys Gln Leu Gly Glu Lys 
            420                 425                 430         


Glu Glu Phe Asn Phe Lys Phe Leu Pro Phe Gly Ile Gly Arg Arg Ala 
        435                 440                 445             


Cys Pro Gly Ala Asn Leu Gly Ile Arg Asn Val Ser Leu Ala Leu Gly 
    450                 455                 460                 


Ala Leu Leu Gln Cys Phe Tyr Trp Asp Lys Val Gly Glu Lys Glu Gly 
465                 470                 475                 480 


Asp Met Asp Thr Asn Asn Asp Asp Lys Leu Thr Leu His Lys Ala Lys 
                485                 490                 495     


Pro Cys Glu Ala Met Cys Phe Pro Arg Gln Glu Ser Ile Gln Leu Leu 
            500                 505                 510         


Ser Gln Leu 
        515 


<210>  11
<211>  3042
<212>  DNA
<213>  Ophiorrhiza pumila

<400>  11
atggagaatc tctactacta cttagtgtca atcttcttgt gtggtttttt cctgatccta       60

tccaaacaat tgtttttcaa caagaacaag aagttacctc ctagtcctcg tgctcttcca      120

ataattggcc atctccatct catcaagaac gaactctatg aagattttac ttcattatca      180

tctacatacg gtccagtttt ctttctccga tttggctgcc ggtcctatgt tgttgtgtct      240

tctccatctg ctgttgaaga gtgtttcaca aagaatgata ttatacttgc aaaccgtgat      300

aagaccatgg ctggggacag gttgacctat aactatggaa catttgcaat ggctccttat      360

ggggatatat ggagggttct tcgtcgcctc actgttgttg aatctttatc tttcaacaga      420

ctccaaaagt cctcaaatat cagggaagaa gaaattcaga tgattgttcg ttcactcttt      480

cgagtctcaa agaatggaag ccaacgagtt gatttgaact attggatttc agtttttaca      540

ctcaatgtta ttatgaggat ggttactgga agatgctcaa ttagagagga agatgctgga      600

gacgagttgg ggaagcaaat agttaaagaa ttcaaagaca actttgctac aggcctttca      660

atgaacttgt gcgacttctt cccgatatta aggtggtttg gttacaaagg gctggaaaag      720

agaatgatca ttttgcacaa gaagagagat gcattccttc agggtttagt agatgaactt      780

cgatcaaata aatctaattt ttctccttcc ggcactggaa tgaacgaaga gaagaagaag      840

gcattaattg aatccctcct ttctcatcag gaactagaac ctgattttct caaagatgac      900

tctataaaga gtattgcatt gtccatcttt atagcaggaa gagaaacatc atccatgacc      960

attgaatggg ctatgtcact cttactgaat cacccggaag caatgcacaa gttaaggact     1020

gaaatcgaca acaacgtagg acacaaaaga ttgttggatg aatcggatat tccaaagctt     1080

ccttatctgc gttgtgtcgt ggatgagaca ttgagactgt atcctccagc accactgctt     1140

ctacctcatt atgcatctga aaattgtaga gtttgggact atgacattcc aaaaggtacg     1200

actgttttag ctaatgcttg ggccatacac agggatccaa aactctggga tatgcctgaa     1260

aagttcatgc cagagagatt tgaggctaaa caattagggg aaaaagaaga gttcaatttc     1320

aagtttctac catttgggat agggaggaga gcatgtcccg gagccaattt gggcattcgg     1380

aacgtttctt tggcattggg tgcattgtta cagtgctttt attgggaaaa agttggagag     1440

aaggaaggcg atatggacat gatagtggat agagccatag agttctattt tgccatggag     1500

aatctctact actacttagt ctcaatcttt ttgtgttgct ttttcgtgat cctattccta     1560

tccaaacaat tgctgttcaa caagaacaag aagttgccac ccagtcctcc tgctcttcca     1620

ataattggcc atctccatct catcaagaac gaactctatc gagatttaac ttcattatca     1680

tctacatacg gtccagtttt ctttctcaaa tttggttgcc ggtcctatgt tgttgtgtct     1740

tctccatctg ccgttgaaga gtgcttcaca aagaatgata atatacttgc aaaccgtcct     1800

aacaccatgg cttcggacat ttttacctat aactactcaa caattggatc ggctccttat     1860

gggaatttat ggagggttct tcgtcgcctc actgttgctg aatctttatc atccaacagc     1920

cttcagaagt cctcaaatat cagggaagaa gaaattcaga tgattgttcg ttcactcttt     1980

cgaatctcaa agaatggaag ccaacgagtt gatttgaact actggatttc agtttttaca     2040

ctcaatatta ttacgaggat gattactgga agatgctcaa ttagagagga ggatgccgga     2100

gatgagttgg ggaagcaaat agctaaagaa ttcaaagata ggtttgcttc aggcactgca     2160

atgaacttgt gcgacttctt tccgatatta aggtggtttg gttacaaagg gttggaaaag     2220

aaaatgatca gtttgtacaa gaagagagat gcattccttc agggtttagt agataaattt     2280

cgatcagata aatctaacaa cgaagagaag aagaagacca taattgaatc tctcctctct     2340

catcaggaag aactagaact aaagcctgat tttctctcag atggcttaat aaagagtact     2400

gcgctgtcca tctttatagc aggaagagaa acatcatccc tgaccattga atgggctatg     2460

tcactcttac tgaaacaccc gaaagcaatg cacaagttaa ggactgaaat cgacaacaat     2520

gtaggacaca aaagattgtt ggatgaatcg gatattccaa agcttcctta tctgcgttgt     2580

gtcgtggatg agacattgag actgtatcct ccagcaccac tgcttctacc tcattatgca     2640

tctgaaaatt gtagagtttg ggactatgac attccaaaag gtacgactgt tttagctaac     2700

gcttgggcca tacacaggga tccaaaactc tgggatatgc ctgaaaagtt catgccagag     2760

agatttgagg ctaaacaatt aggggaaaaa gaagagttca atttcaagtt tctaccattt     2820

gggataggga ggagagcatg tcccggagcc aatttgggca ttcggaacgt ttctttggca     2880

ttgggtgcat tgttacagtg cttttattgg gacaaagttg gagaaaagga aggtgatatg     2940

gacactaaca acgacgataa actcactttg cataaggcca aaccctgcga ggccatgtgt     3000

tttccacgcc aagaatcaat ccaacttctc tcgcaactct ga                        3042


<210>  12
<211>  1443
<212>  DNA
<213>  Ophiorrhiza pumila

<400>  12
atgtcaaccc gagttctttg ggataagatt cctatcagac taagagtttt aatcctactg       60

caactctacc agacttcatc agttttcttt ctccgatttg gctgccggtc ctatgttgtt      120

gtgtcttctc catctgctgt tggagagtgt ttcacaaaga atgatattat acttgcaaac      180

cgtcctaaga ccatggctgg ggacaggttg acctataact atggatcatt tggagtggct      240

ccgtatgggg atatatggag ggttcttcgt cgcctcactg ttgttgaatc tttatctttc      300

aacagcctcc aaaagtcctc taatatcagg gaagaagaaa ttcagatgat tgttcgttca      360

ctctatcgag tctcaaagaa tggaagccaa cgagttgatt tgaactattg gatttcagtt      420

tttacactca atgttattat gaggatggtt actggaagat gctcaattag agaggaagat      480

gctggagacg agttggggaa gcaaatagtt aaagaattca aagacaactt tgctacagcc      540

ctttcaatga gcttgtgcga cttcttcccg atattaaggt ggtttggtta caaagggctg      600

gaaaagagaa tgatcatttt gcacaagaag agagatgcat tccttcaggg tttagtagat      660

gaacttcgat caaataaatc taatttttct ccttccggca ctggaatgaa cgaagagaag      720

aagaaggcat taattcaatc cctcctttct catcaggaac tagaacctga ttttctcaaa      780

gatgactcta taaagagtat tgcattgtcc atctttctag caggaagaga aacgtcatcc      840

atgaccattg aatgggctat gtcactctta ctgaatcacc aggaagcaat gcagaagtta      900

aggactgaaa tcgacaacaa cgtaggacac aaaagattgt tggatgaatc ggatattcca      960

aagcttcctt atctgcgttg tgtagtggat gagacgatga gactgtatcc tgcagcacca     1020

ctgcttcttc ctcattatgc gtctgaaaat tgtagagttt gtgactatga cattccaaaa     1080

ggtacgactg ttttaactaa tgcttgggcc atacacaggg atccaaaact ctgggatatg     1140

cctgaaaagt tcatgccaga gagatttgag gctaaacaaa tagggggaaa agaagagttc     1200

aatttcaagt ttctaccatt tgggataggg aggagagcat gtcccggagc caatttggcc     1260

attcggaacg tttctttggc attgggtgca ttgttacagt gcttttattg ggaaaaagtt     1320

ggagagaagg aaggcgatat ggacagtaag aacgatgata gagtcacttt gcagaaggcc     1380

aaacccttgg aggccatttg ttttccacgc caagaatcaa tccaacttct ctcgcaactc     1440

tga                                                                   1443


<210>  13
<211>  1557
<212>  DNA
<213>  Ophiorrhiza pumila

<400>  13
atggagaatc tctactatta cttagtgtca atcttcttgt gtggtgtttt cctgattcta       60

tccaaacaat tgttgttcaa caagaacaag aagttacctc ctagtcctcg tgttcttcca      120

ataattggcc atctccatct catcaagaac gaattctatg aagattttac ttcattatca      180

tctacatacg gtccagtttt ctttctccga tttggctgcc ggtcctatgt tgttgtgtct      240

tctccatctg ctgttggaga gtgtttcaca aagaatgata ttatacttgc aaaccgtcct      300

aagaccatgg ctggggacag gttgacctat aactatggat catttggagt ggctccttat      360

ggggatatat ggagggttct tcgtcgcctc actgttgttg aatctttatc tttcaacagc      420

ctccaaaagt cctcaaatat cagggaagaa gaaattcaga tgattgttcg ttcactctat      480

cgagtctcaa agaatggaag ccaacgagtt gatttgaact attggatttc agtttttaca      540

ctcaatgtta ttatgaggat ggttactgga agatgctcaa ttagagagga agatgctgga      600

gacgagttgg ggaagcaaat agttaaagaa ttcaaagaca actttgctac agccctttca      660

atgagcttgt gcgacttctt cccgatatta aggtggtttg gttacaaagg gctggaaaag      720

agaatgatca ttttgcacaa gaagagagat gcattccttc agggtttagt agatgaactt      780

cgatcaaata aatctaattt ttctccttcc ggcactggaa tgaacgaaga gaagaagaag      840

gcattaattc aatccctcct ttctcatcag gaactagaac ctgattttct caaagatgac      900

tctataaaga gtattgcatt gtccatcttt ctagcaggaa gagaaacgtc atccatgacc      960

attgaatggg ctatgtcact cttactgaat caccaggaag caatgcagaa gttaaggact     1020

gaaatcgaca acaacgtagg acacaaaaga ttgttggatg aatcggatat tccaaagctt     1080

ccttatctgc gttgtgtagt ggatgagacg atgagactgt atcctgcagc accactgctt     1140

cttcctcatt atgcgtctga aaattgtaga gtttgtgact atgacattcc aaaaggtacg     1200

actgttttaa ctaatgcttg ggccatacac agggatccaa aactctggga tatgcctgaa     1260

aagttcatgc cagagagatt tgaggctaaa caaatagggg gaaaagaaga gttcaatttc     1320

aagtttctac catttgggat agggaggaga gcatgtcccg gagccaattt ggccattcgg     1380

aacgtttctt tggcattggg tgcattgtta cagtgctttt attgggaaaa agttggagag     1440

aaggaaggcg atatggacag taagaacgat gatagagtca ctttgcagaa ggccaaaccc     1500

ttggaggcca tttgttttcc acgccaagaa tcaatccaac ttctctcgca actctga        1557


<210>  14
<211>  515
<212>  PRT
<213>  Ophiorrhiza pumila

<400>  14

Met Glu Asn Leu Tyr Tyr Tyr Leu Val Ser Ile Phe Leu Cys Cys Phe 
1               5                   10                  15      


Phe Val Ile Leu Phe Leu Ser Lys Gln Leu Leu Phe Asn Lys Asn Lys 
            20                  25                  30          


Lys Leu Pro Pro Ser Pro Pro Ala Leu Pro Ile Ile Gly His Leu His 
        35                  40                  45              


Leu Ile Lys Asn Glu Leu Tyr Arg Asp Leu Thr Ser Leu Ser Ser Thr 
    50                  55                  60                  


Tyr Gly Pro Val Phe Phe Leu Lys Phe Gly Cys Arg Ser Tyr Val Val 
65                  70                  75                  80  


Val Ser Ser Pro Ser Ala Val Glu Glu Cys Phe Thr Lys Asn Asp Asn 
                85                  90                  95      


Ile Leu Ala Asn Arg Pro Asn Thr Met Ala Ser Asp Ile Phe Thr Tyr 
            100                 105                 110         


Asn Tyr Ser Thr Ile Gly Ser Ala Pro Tyr Gly Asn Leu Trp Arg Val 
        115                 120                 125             


Leu Arg Arg Leu Thr Val Ala Glu Ser Leu Ser Ser Asn Ser Leu Gln 
    130                 135                 140                 


Lys Ser Ser Asn Ile Arg Glu Glu Glu Ile Gln Met Ile Val Arg Ser 
145                 150                 155                 160 


Leu Phe Arg Ile Ser Lys Asn Gly Ser Gln Arg Val Asp Leu Asn Tyr 
                165                 170                 175     


Trp Ile Ser Val Phe Thr Leu Asn Ile Ile Thr Arg Met Ile Thr Gly 
            180                 185                 190         


Arg Cys Ser Ile Arg Glu Glu Asp Ala Gly Asp Glu Leu Gly Lys Gln 
        195                 200                 205             


Ile Ala Lys Glu Phe Lys Asp Arg Phe Ala Ser Gly Thr Ala Met Asn 
    210                 215                 220                 


Leu Cys Asp Phe Phe Pro Ile Leu Arg Trp Phe Gly Tyr Lys Gly Leu 
225                 230                 235                 240 


Glu Lys Lys Met Ile Ser Leu Tyr Lys Lys Arg Asp Ala Phe Leu Gln 
                245                 250                 255     


Gly Leu Val Asp Lys Phe Arg Ser Asp Lys Ser Asn Asn Glu Glu Lys 
            260                 265                 270         


Lys Lys Thr Ile Ile Glu Ser Leu Leu Ser His Gln Glu Glu Leu Glu 
        275                 280                 285             


Leu Lys Pro Asp Phe Leu Ser Asp Gly Leu Ile Lys Ser Thr Ala Leu 
    290                 295                 300                 


Ser Ile Phe Ile Ala Gly Arg Glu Thr Ser Ser Leu Thr Ile Glu Trp 
305                 310                 315                 320 


Ala Met Ser Leu Leu Leu Lys His Pro Lys Ala Met His Lys Leu Arg 
                325                 330                 335     


Thr Glu Ile Asp Asn Asn Val Gly His Lys Arg Leu Leu Asp Glu Ser 
            340                 345                 350         


Asp Ile Pro Lys Leu Pro Tyr Leu Arg Cys Val Val Asp Glu Thr Leu 
        355                 360                 365             


Arg Leu Tyr Pro Pro Ala Pro Leu Leu Leu Pro His Tyr Ala Ser Glu 
    370                 375                 380                 


Asn Cys Arg Val Trp Asp Tyr Asp Ile Pro Lys Gly Thr Thr Val Leu 
385                 390                 395                 400 


Ala Asn Ala Trp Ala Ile His Arg Asp Pro Lys Leu Trp Asp Met Pro 
                405                 410                 415     


Glu Lys Phe Met Pro Glu Arg Phe Glu Ala Lys Gln Leu Gly Glu Lys 
            420                 425                 430         


Glu Glu Phe Asn Phe Lys Phe Leu Pro Phe Gly Ile Gly Arg Arg Ala 
        435                 440                 445             


Cys Pro Gly Ala Asn Leu Gly Ile Arg Asn Val Ser Leu Ala Leu Gly 
    450                 455                 460                 


Ala Leu Leu Gln Cys Phe Tyr Trp Asp Lys Val Gly Glu Lys Glu Gly 
465                 470                 475                 480 


Asp Met Asp Thr Asn Asn Asp Asp Lys Leu Thr Leu His Lys Ala Lys 
                485                 490                 495     


Pro Cys Glu Ala Met Cys Phe Pro Arg Gln Glu Ser Ile Gln Leu Leu 
            500                 505                 510         


Ser Gln Leu 
        515 


<210>  15
<211>  480
<212>  PRT
<213>  Ophiorrhiza pumila

<400>  15

Met Ser Thr Arg Val Leu Trp Asp Lys Ile Pro Ile Arg Leu Arg Val 
1               5                   10                  15      


Leu Ile Leu Leu Gln Leu Tyr Gln Thr Ser Ser Val Phe Phe Leu Arg 
            20                  25                  30          


Phe Gly Cys Arg Ser Tyr Val Val Val Ser Ser Pro Ser Ala Val Gly 
        35                  40                  45              


Glu Cys Phe Thr Lys Asn Asp Ile Ile Leu Ala Asn Arg Pro Lys Thr 
    50                  55                  60                  


Met Ala Gly Asp Arg Leu Thr Tyr Asn Tyr Gly Ser Phe Gly Val Ala 
65                  70                  75                  80  


Pro Tyr Gly Asp Ile Trp Arg Val Leu Arg Arg Leu Thr Val Val Glu 
                85                  90                  95      


Ser Leu Ser Phe Asn Ser Leu Gln Lys Ser Ser Asn Ile Arg Glu Glu 
            100                 105                 110         


Glu Ile Gln Met Ile Val Arg Ser Leu Tyr Arg Val Ser Lys Asn Gly 
        115                 120                 125             


Ser Gln Arg Val Asp Leu Asn Tyr Trp Ile Ser Val Phe Thr Leu Asn 
    130                 135                 140                 


Val Ile Met Arg Met Val Thr Gly Arg Cys Ser Ile Arg Glu Glu Asp 
145                 150                 155                 160 


Ala Gly Asp Glu Leu Gly Lys Gln Ile Val Lys Glu Phe Lys Asp Asn 
                165                 170                 175     


Phe Ala Thr Ala Leu Ser Met Ser Leu Cys Asp Phe Phe Pro Ile Leu 
            180                 185                 190         


Arg Trp Phe Gly Tyr Lys Gly Leu Glu Lys Arg Met Ile Ile Leu His 
        195                 200                 205             


Lys Lys Arg Asp Ala Phe Leu Gln Gly Leu Val Asp Glu Leu Arg Ser 
    210                 215                 220                 


Asn Lys Ser Asn Phe Ser Pro Ser Gly Thr Gly Met Asn Glu Glu Lys 
225                 230                 235                 240 


Lys Lys Ala Leu Ile Gln Ser Leu Leu Ser His Gln Glu Leu Glu Pro 
                245                 250                 255     


Asp Phe Leu Lys Asp Asp Ser Ile Lys Ser Ile Ala Leu Ser Ile Phe 
            260                 265                 270         


Leu Ala Gly Arg Glu Thr Ser Ser Met Thr Ile Glu Trp Ala Met Ser 
        275                 280                 285             


Leu Leu Leu Asn His Gln Glu Ala Met Gln Lys Leu Arg Thr Glu Ile 
    290                 295                 300                 


Asp Asn Asn Val Gly His Lys Arg Leu Leu Asp Glu Ser Asp Ile Pro 
305                 310                 315                 320 


Lys Leu Pro Tyr Leu Arg Cys Val Val Asp Glu Thr Met Arg Leu Tyr 
                325                 330                 335     


Pro Ala Ala Pro Leu Leu Leu Pro His Tyr Ala Ser Glu Asn Cys Arg 
            340                 345                 350         


Val Cys Asp Tyr Asp Ile Pro Lys Gly Thr Thr Val Leu Thr Asn Ala 
        355                 360                 365             


Trp Ala Ile His Arg Asp Pro Lys Leu Trp Asp Met Pro Glu Lys Phe 
    370                 375                 380                 


Met Pro Glu Arg Phe Glu Ala Lys Gln Ile Gly Gly Lys Glu Glu Phe 
385                 390                 395                 400 


Asn Phe Lys Phe Leu Pro Phe Gly Ile Gly Arg Arg Ala Cys Pro Gly 
                405                 410                 415     


Ala Asn Leu Ala Ile Arg Asn Val Ser Leu Ala Leu Gly Ala Leu Leu 
            420                 425                 430         


Gln Cys Phe Tyr Trp Glu Lys Val Gly Glu Lys Glu Gly Asp Met Asp 
        435                 440                 445             


Ser Lys Asn Asp Asp Arg Val Thr Leu Gln Lys Ala Lys Pro Leu Glu 
    450                 455                 460                 


Ala Ile Cys Phe Pro Arg Gln Glu Ser Ile Gln Leu Leu Ser Gln Leu 
465                 470                 475                 480 


<210>  16
<211>  518
<212>  PRT
<213>  Ophiorrhiza pumila

<400>  16

Met Glu Asn Leu Tyr Tyr Tyr Leu Val Ser Ile Phe Leu Cys Gly Val 
1               5                   10                  15      


Phe Leu Ile Leu Ser Lys Gln Leu Leu Phe Asn Lys Asn Lys Lys Leu 
            20                  25                  30          


Pro Pro Ser Pro Arg Val Leu Pro Ile Ile Gly His Leu His Leu Ile 
        35                  40                  45              


Lys Asn Glu Phe Tyr Glu Asp Phe Thr Ser Leu Ser Ser Thr Tyr Gly 
    50                  55                  60                  


Pro Val Phe Phe Leu Arg Phe Gly Cys Arg Ser Tyr Val Val Val Ser 
65                  70                  75                  80  


Ser Pro Ser Ala Val Gly Glu Cys Phe Thr Lys Asn Asp Ile Ile Leu 
                85                  90                  95      


Ala Asn Arg Pro Lys Thr Met Ala Gly Asp Arg Leu Thr Tyr Asn Tyr 
            100                 105                 110         


Gly Ser Phe Gly Val Ala Pro Tyr Gly Asp Ile Trp Arg Val Leu Arg 
        115                 120                 125             


Arg Leu Thr Val Val Glu Ser Leu Ser Phe Asn Ser Leu Gln Lys Ser 
    130                 135                 140                 


Ser Asn Ile Arg Glu Glu Glu Ile Gln Met Ile Val Arg Ser Leu Tyr 
145                 150                 155                 160 


Arg Val Ser Lys Asn Gly Ser Gln Arg Val Asp Leu Asn Tyr Trp Ile 
                165                 170                 175     


Ser Val Phe Thr Leu Asn Val Ile Met Arg Met Val Thr Gly Arg Cys 
            180                 185                 190         


Ser Ile Arg Glu Glu Asp Ala Gly Asp Glu Leu Gly Lys Gln Ile Val 
        195                 200                 205             


Lys Glu Phe Lys Asp Asn Phe Ala Thr Ala Leu Ser Met Ser Leu Cys 
    210                 215                 220                 


Asp Phe Phe Pro Ile Leu Arg Trp Phe Gly Tyr Lys Gly Leu Glu Lys 
225                 230                 235                 240 


Arg Met Ile Ile Leu His Lys Lys Arg Asp Ala Phe Leu Gln Gly Leu 
                245                 250                 255     


Val Asp Glu Leu Arg Ser Asn Lys Ser Asn Phe Ser Pro Ser Gly Thr 
            260                 265                 270         


Gly Met Asn Glu Glu Lys Lys Lys Ala Leu Ile Gln Ser Leu Leu Ser 
        275                 280                 285             


His Gln Glu Leu Glu Pro Asp Phe Leu Lys Asp Asp Ser Ile Lys Ser 
    290                 295                 300                 


Ile Ala Leu Ser Ile Phe Leu Ala Gly Arg Glu Thr Ser Ser Met Thr 
305                 310                 315                 320 


Ile Glu Trp Ala Met Ser Leu Leu Leu Asn His Gln Glu Ala Met Gln 
                325                 330                 335     


Lys Leu Arg Thr Glu Ile Asp Asn Asn Val Gly His Lys Arg Leu Leu 
            340                 345                 350         


Asp Glu Ser Asp Ile Pro Lys Leu Pro Tyr Leu Arg Cys Val Val Asp 
        355                 360                 365             


Glu Thr Met Arg Leu Tyr Pro Ala Ala Pro Leu Leu Leu Pro His Tyr 
    370                 375                 380                 


Ala Ser Glu Asn Cys Arg Val Cys Asp Tyr Asp Ile Pro Lys Gly Thr 
385                 390                 395                 400 


Thr Val Leu Thr Asn Ala Trp Ala Ile His Arg Asp Pro Lys Leu Trp 
                405                 410                 415     


Asp Met Pro Glu Lys Phe Met Pro Glu Arg Phe Glu Ala Lys Gln Ile 
            420                 425                 430         


Gly Gly Lys Glu Glu Phe Asn Phe Lys Phe Leu Pro Phe Gly Ile Gly 
        435                 440                 445             


Arg Arg Ala Cys Pro Gly Ala Asn Leu Ala Ile Arg Asn Val Ser Leu 
    450                 455                 460                 


Ala Leu Gly Ala Leu Leu Gln Cys Phe Tyr Trp Glu Lys Val Gly Glu 
465                 470                 475                 480 


Lys Glu Gly Asp Met Asp Ser Lys Asn Asp Asp Arg Val Thr Leu Gln 
                485                 490                 495     


Lys Ala Lys Pro Leu Glu Ala Ile Cys Phe Pro Arg Gln Glu Ser Ile 
            500                 505                 510         


Gln Leu Leu Ser Gln Leu 
        515             


<210>  17
<211>  1536
<212>  DNA
<213>  Nothapodytes nimmoniana

<400>  17
atggagatgc tttacttcta ccttattttt ctggtctcag ttctcctgat attcaaacac       60

atcttccatt ttaacaaaag taaattacca ccaagtcctc catatattcc gataattggc      120

cacctctacc tcataaaggg tagtatccac caagcacttc agtctctgtc atcaaaatat      180

ggtccaattc tattcctccg gctcggcgtc cggtccatgt tggttgtctc ttctccctct      240

gccgtggaag aatgcttcac caagaacgac atcatatttg caaaccggcc ccgaaccttg      300

gccggcgacc tgttgactta caactacaga gctttcgtgt ggactccgta cggacatatt      360

tggcggagcc tccgccgtct ctcggtggtt gaactcttct cttcaaccag cgtccacagg      420

tcttcagcag ttcgtgaaga tgaaatccga accctcgttc gacatctcta taaagtatca      480

aagagtggga atccaaaggt ggaattcaag tactggttct caatttgttt gttcaatacc      540

ataacgagga ttgtcgccgg gagacaggtt gtaccggagg aagacgcagg cggggaggcc      600

gggcggcgaa ttatggcaga ccttagagag agattcttta cgaacgtcgg aatgaatatg      660

tgcgatttcc ttccaattct gaggtggttt ggttacaaag ggctggaaaa aaaattgatg      720

gtagcgttca aaaggaggga cgagttcttg cagggcctac tagatgagtt tcgattaaag      780

aaaatgaatt cctcatctca gaaacatgtg aaagatggaa aagagaaagg tccgttgata      840

gaaactctgt tgtcccttcg tgaatcagag cctgagttct acaccgttga tgtcatcaaa      900

agtttaatgc tggtaatgtt tgtggctgga acagagacaa ctgcaactac tgtagagtgg      960

gcaatgtcac ttcttctaac acaccctgaa acacttgaca agctaagaac agagattgac     1020

aacaatgtca gggaagaacg actactaacc gacatggatc tttctaaact tccttatctc     1080

cgttgtgtta tcaacgaagc cctcagattg taccccccag tgccacttct attaccacat     1140

ttctcatcta aagattgtac aattggaggg catgtgatac ccgaaggtac aatcctagtt     1200

gttaattctt gggcattgca aagggatccc aacgtttggg aggagccaca caagttcaag     1260

ccagagagat ttgagatgga ggaggaaaaa gaagggtttg gttataaatt cgttccgttt     1320

ggggtaggga ggagggcatg ccctggagtc aatatgggca tgagggcagc tttgttggca     1380

cttggtacac tgattcaatg ttttgagtgg gaaaaggttg gccaatttga gatggaaatg     1440

aggtacaata atggagtaac tttgcagaag gctaaaccct ttgaagctaa ttgcaaacca     1500

agacaaaatt ttgttcaact ccttggtcag ctttga                               1536


<210>  18
<211>  511
<212>  PRT
<213>  Nothapodytes nimmoniana

<400>  18

Met Glu Met Leu Tyr Phe Tyr Leu Ile Phe Leu Val Ser Val Leu Leu 
1               5                   10                  15      


Ile Phe Lys His Ile Phe His Phe Asn Lys Ser Lys Leu Pro Pro Ser 
            20                  25                  30          


Pro Pro Tyr Ile Pro Ile Ile Gly His Leu Tyr Leu Ile Lys Gly Ser 
        35                  40                  45              


Ile His Gln Ala Leu Gln Ser Leu Ser Ser Lys Tyr Gly Pro Ile Leu 
    50                  55                  60                  


Phe Leu Arg Leu Gly Val Arg Ser Met Leu Val Val Ser Ser Pro Ser 
65                  70                  75                  80  


Ala Val Glu Glu Cys Phe Thr Lys Asn Asp Ile Ile Phe Ala Asn Arg 
                85                  90                  95      


Pro Arg Thr Leu Ala Gly Asp Leu Leu Thr Tyr Asn Tyr Arg Ala Phe 
            100                 105                 110         


Val Trp Thr Pro Tyr Gly His Ile Trp Arg Ser Leu Arg Arg Leu Ser 
        115                 120                 125             


Val Val Glu Leu Phe Ser Ser Thr Ser Val His Arg Ser Ser Ala Val 
    130                 135                 140                 


Arg Glu Asp Glu Ile Arg Thr Leu Val Arg His Leu Tyr Lys Val Ser 
145                 150                 155                 160 


Lys Ser Gly Asn Pro Lys Val Glu Phe Lys Tyr Trp Phe Ser Ile Cys 
                165                 170                 175     


Leu Phe Asn Thr Ile Thr Arg Ile Val Ala Gly Arg Gln Val Val Pro 
            180                 185                 190         


Glu Glu Asp Ala Gly Gly Glu Ala Gly Arg Arg Ile Met Ala Asp Leu 
        195                 200                 205             


Arg Glu Arg Phe Phe Thr Asn Val Gly Met Asn Met Cys Asp Phe Leu 
    210                 215                 220                 


Pro Ile Leu Arg Trp Phe Gly Tyr Lys Gly Leu Glu Lys Lys Leu Met 
225                 230                 235                 240 


Val Ala Phe Lys Arg Arg Asp Glu Phe Leu Gln Gly Leu Leu Asp Glu 
                245                 250                 255     


Phe Arg Leu Lys Lys Met Asn Ser Ser Ser Gln Lys His Val Lys Asp 
            260                 265                 270         


Gly Lys Glu Lys Gly Pro Leu Ile Glu Thr Leu Leu Ser Leu Arg Glu 
        275                 280                 285             


Ser Glu Pro Glu Phe Tyr Thr Val Asp Val Ile Lys Ser Leu Met Leu 
    290                 295                 300                 


Val Met Phe Val Ala Gly Thr Glu Thr Thr Ala Thr Thr Val Glu Trp 
305                 310                 315                 320 


Ala Met Ser Leu Leu Leu Thr His Pro Glu Thr Leu Asp Lys Leu Arg 
                325                 330                 335     


Thr Glu Ile Asp Asn Asn Val Arg Glu Glu Arg Leu Leu Thr Asp Met 
            340                 345                 350         


Asp Leu Ser Lys Leu Pro Tyr Leu Arg Cys Val Ile Asn Glu Ala Leu 
        355                 360                 365             


Arg Leu Tyr Pro Pro Val Pro Leu Leu Leu Pro His Phe Ser Ser Lys 
    370                 375                 380                 


Asp Cys Thr Ile Gly Gly His Val Ile Pro Glu Gly Thr Ile Leu Val 
385                 390                 395                 400 


Val Asn Ser Trp Ala Leu Gln Arg Asp Pro Asn Val Trp Glu Glu Pro 
                405                 410                 415     


His Lys Phe Lys Pro Glu Arg Phe Glu Met Glu Glu Glu Lys Glu Gly 
            420                 425                 430         


Phe Gly Tyr Lys Phe Val Pro Phe Gly Val Gly Arg Arg Ala Cys Pro 
        435                 440                 445             


Gly Val Asn Met Gly Met Arg Ala Ala Leu Leu Ala Leu Gly Thr Leu 
    450                 455                 460                 


Ile Gln Cys Phe Glu Trp Glu Lys Val Gly Gln Phe Glu Met Glu Met 
465                 470                 475                 480 


Arg Tyr Asn Asn Gly Val Thr Leu Gln Lys Ala Lys Pro Phe Glu Ala 
                485                 490                 495     


Asn Cys Lys Pro Arg Gln Asn Phe Val Gln Leu Leu Gly Gln Leu 
            500                 505                 510     


<210>  19
<211>  1536
<212>  DNA
<213>  Nothapodytes nimmoniana

<400>  19
atggagatgc tttacttcta ccttattttt ctggtctcag ttctcctgat attcaaacac       60

atcttccatt ttaacaaaag taaattacca ccaagtcctc catatattcc gataattggc      120

cacctctacc tcataaaggg tagtatccac caagcacttc agtctctgtc atcaaaatat      180

ggtccaattc tattcctccg gctcggcgtc cggtccatgt tggttgtctc ttctccctct      240

gccgtggaag aatgcttcac caagaacgac atcatatttg caaaccggcc ccgaaccttg      300

gccggcgacc tgttgactta caactacaga gctttcgtgt ggactccgta cggacatatt      360

tggcggagcc tccgccgtct ctcggtggtt gaactcttct cttcaaccag cgtccacagg      420

tcttcagcag ttcgtgaaga tgaaatccga accctcgttc gacatctcta taaagtatca      480

aagagtggga atccaaaggt ggaattcaag tactggttct caatttgttt gttcaatacc      540

ataacgagga ttgtcgccgg gagacaggtt gtaccggagg aagacgcagg cggggaggcc      600

gggcggcgaa ttatggcaga ccttagagag agattcttta cgaacgtcgg aatgaatatg      660

tgcgatttcc ttccaattct gaggtggttt ggttacaaag ggctggaaaa aaaattgatg      720

gtagcgttca aaaggaggga cgagttcttg cagggcctac tagatgagtt tcgattaaag      780

aaaatgaatt cctcatctca gaaacatgtg aaagatggaa aagagaaagg tccgttgata      840

gaaactctgt tgtcccttcg tgaatcagag cctgagttct acaccgttga tgtcatcaaa      900

agtttaatgc tggtaatgtt tgtggctgga acagagacaa ctgcaactac tgtagagtgg      960

gcaatgtcac ttcttctaac acaccctgaa acacttgaca agctaagaac agagattgac     1020

aacaatgtca gggaagaacg actactaacc gacatggatc tttctaaact tccttatctc     1080

cgttgtgtta tcaacgaagc cctcagattg taccccccag tgccacttct attaccacat     1140

ttctcatcta aagattgtac aattggaggg catgtgatac ccgaaggtac aatcctagtt     1200

gttaattctt gggcattgca aagggatccc aacgtttggg aggagccaca caagttcaag     1260

ccagagagat ttgagatgga ggaggaaaaa gaagggtttg gttataaatt cgttccgttt     1320

ggggtaggga ggagggcatg ccctggagtc aatatgggca tgagggcagc tttgttggca     1380

cttggtacac tgattcaatg ttttgagtgg gaaaaggttg gccaatttga gatggaaatg     1440

aggtacaata atggagtaac tttgcagaag gctaaaccct ttgaagctaa ttgcaaacca     1500

agacaaaatt ttgttcaact ccttggtcag ctttga                               1536


<210>  20
<211>  511
<212>  PRT
<213>  Nothapodytes nimmoniana

<400>  20

Met Glu Met Leu Tyr Phe Tyr Leu Ile Phe Leu Val Ser Val Leu Leu 
1               5                   10                  15      


Ile Phe Lys His Ile Phe His Phe Asn Lys Ser Lys Leu Pro Pro Ser 
            20                  25                  30          


Pro Pro Tyr Ile Pro Ile Ile Gly His Leu Tyr Leu Ile Lys Gly Ser 
        35                  40                  45              


Ile His Gln Ala Leu Gln Ser Leu Ser Ser Lys Tyr Gly Pro Ile Leu 
    50                  55                  60                  


Phe Leu Arg Leu Gly Val Arg Ser Met Leu Val Val Ser Ser Pro Ser 
65                  70                  75                  80  


Ala Val Glu Glu Cys Phe Thr Lys Asn Asp Ile Ile Phe Ala Asn Arg 
                85                  90                  95      


Pro Arg Thr Leu Ala Gly Asp Leu Leu Thr Tyr Asn Tyr Arg Ala Phe 
            100                 105                 110         


Val Trp Thr Pro Tyr Gly His Ile Trp Arg Ser Leu Arg Arg Leu Ser 
        115                 120                 125             


Val Val Glu Leu Phe Ser Ser Thr Ser Val His Arg Ser Ser Ala Val 
    130                 135                 140                 


Arg Glu Asp Glu Ile Arg Thr Leu Val Arg His Leu Tyr Lys Val Ser 
145                 150                 155                 160 


Lys Ser Gly Asn Pro Lys Val Glu Phe Lys Tyr Trp Phe Ser Ile Cys 
                165                 170                 175     


Leu Phe Asn Thr Ile Thr Arg Ile Val Ala Gly Arg Gln Val Val Pro 
            180                 185                 190         


Glu Glu Asp Ala Gly Gly Glu Ala Gly Arg Arg Ile Met Ala Asp Leu 
        195                 200                 205             


Arg Glu Arg Phe Phe Thr Asn Val Gly Met Asn Met Cys Asp Phe Leu 
    210                 215                 220                 


Pro Ile Leu Arg Trp Phe Gly Tyr Lys Gly Leu Glu Lys Lys Leu Met 
225                 230                 235                 240 


Val Ala Phe Lys Arg Arg Asp Glu Phe Leu Gln Gly Leu Leu Asp Glu 
                245                 250                 255     


Phe Arg Leu Lys Lys Met Asn Ser Ser Ser Gln Lys His Val Lys Asp 
            260                 265                 270         


Gly Lys Glu Lys Gly Pro Leu Ile Glu Thr Leu Leu Ser Leu Arg Glu 
        275                 280                 285             


Ser Glu Pro Glu Phe Tyr Thr Val Asp Val Ile Lys Ser Leu Met Leu 
    290                 295                 300                 


Val Met Phe Val Ala Gly Thr Glu Thr Thr Ala Thr Thr Val Glu Trp 
305                 310                 315                 320 


Ala Met Ser Leu Leu Leu Thr His Pro Glu Thr Leu Asp Lys Leu Arg 
                325                 330                 335     


Thr Glu Ile Asp Asn Asn Val Arg Glu Glu Arg Leu Leu Thr Asp Met 
            340                 345                 350         


Asp Leu Ser Lys Leu Pro Tyr Leu Arg Cys Val Ile Asn Glu Ala Leu 
        355                 360                 365             


Arg Leu Tyr Pro Pro Val Pro Leu Leu Leu Pro His Phe Ser Ser Lys 
    370                 375                 380                 


Asp Cys Thr Ile Gly Gly His Val Ile Pro Glu Gly Thr Ile Leu Val 
385                 390                 395                 400 


Val Asn Ser Trp Ala Leu Gln Arg Asp Pro Asn Val Trp Glu Glu Pro 
                405                 410                 415     


His Lys Phe Lys Pro Glu Arg Phe Glu Met Glu Glu Glu Lys Glu Gly 
            420                 425                 430         


Phe Gly Tyr Lys Phe Val Pro Phe Gly Val Gly Arg Arg Ala Cys Pro 
        435                 440                 445             


Gly Val Asn Met Gly Met Arg Ala Ala Leu Leu Ala Leu Gly Thr Leu 
    450                 455                 460                 


Ile Gln Cys Phe Glu Trp Glu Lys Val Gly Gln Phe Glu Met Glu Met 
465                 470                 475                 480 


Arg Tyr Asn Asn Gly Val Thr Leu Gln Lys Ala Lys Pro Phe Glu Ala 
                485                 490                 495     


Asn Cys Lys Pro Arg Gln Asn Phe Val Gln Leu Leu Gly Gln Leu 
            500                 505                 510     


<210>  21
<211>  1545
<212>  DNA
<213>  Camptotheca acuminata

<400>  21
atggagaaca tatactacta ccttgctctc ctcttgtctg ttctcttcat gttcaaacat       60

ttcttccatc acaatcggaa gttaccacca agtccgcttg cgcttccaat tattggccac      120

ctccacctta tcaagaagtt gctacaccag tcactagagt gtctttcatc ccgatatggt      180

ccaattttat ttctccaatt tggctcccgt tccgttgttg ctttatcttc tccatctgcc      240

gttgaagaat gcttcaccaa aaatgacata atatttgcaa accggcctcg aacaatggct      300

ggggatcatt tcacttacaa ttatactgcc tttgtatggg ctccatatgg tcatctctgg      360

cggagtctcc gccgtctgac tgtcattgag ctcttctctt caaacagcct tcagaagtct      420

tcttttgttc gtgaggggga aattggtaat cttctatgtc acctgttcaa attctcaaac      480

aatggaactc aaaaagtcga gttgaagtat tggttctctc ttttggcatt taatatcatg      540

atgaagatga ttgctggaaa gcgatgtgtt agagatgagg ttgcaggcat ggaggcaggg      600

aagcaaattc ttgaagatct caggggaaag ttcgtttcaa ccacaccatt gaatatttgt      660

gatttctttc caattttgag gtggcttggc tacaaagggc tgaagaagag tatgataagg      720

ttgcacaaga agagagatga attcttgcag ggtttgatag atgagtttcg aattaaaagc      780

agttcttctg ccaataccaa tgctataatg cacagggtac aaaaggtaac attgattgag      840

aaactcttgt ctctgcaaga agcagaacct gacttctatt cggatgacgt tatcaaaagt      900

atcatattgg taacttttgt ggcaggtacc gaaacatcag cagtcactat agaatgggca      960

atgtcacttc ttctaaataa tccacaggca ttggtgaagg tgaaagcaga gatttccagt     1020

catgtcggat ttgagcgctt gctaaatgac tctgatcttc ccaagctaca ttatctccgt     1080

tgtgtcatca atgagacgct cagattatat cctccggtgc cactcctgtt accacactac     1140

tcatcgaaag attgcacttt aggggggtat gaaattccac aaggtacaat tctaactgtg     1200

aatgcttggg caatgcatag ggatcccaag gtgtgggaag atcccaccaa gttcaaccct     1260

gagagatttg aagttgttca aggggaaaga gaagggttca aatttattcc atttggagtg     1320

gggaggagag cttgtccagg tgcagctatg gccttgcgga cagtttcatt agctttgggt     1380

gcactgattc aatgttttga atgggaaaag gttggacagg agaatatgga gacgagtcag     1440

ggaggactga ctttgcccaa ggctgggtgt ttggaggctg tgtgcattcc acgccaagat     1500

tcgattaaac tgctatccca acttgaaagc cattgttctg attaa                     1545


<210>  22
<211>  514
<212>  PRT
<213>  Camptotheca acuminata

<400>  22

Met Glu Asn Ile Tyr Tyr Tyr Leu Ala Leu Leu Leu Ser Val Leu Phe 
1               5                   10                  15      


Met Phe Lys His Phe Phe His His Asn Arg Lys Leu Pro Pro Ser Pro 
            20                  25                  30          


Leu Ala Leu Pro Ile Ile Gly His Leu His Leu Ile Lys Lys Leu Leu 
        35                  40                  45              


His Gln Ser Leu Glu Cys Leu Ser Ser Arg Tyr Gly Pro Ile Leu Phe 
    50                  55                  60                  


Leu Gln Phe Gly Ser Arg Ser Val Val Ala Leu Ser Ser Pro Ser Ala 
65                  70                  75                  80  


Val Glu Glu Cys Phe Thr Lys Asn Asp Ile Ile Phe Ala Asn Arg Pro 
                85                  90                  95      


Arg Thr Met Ala Gly Asp His Phe Thr Tyr Asn Tyr Thr Ala Phe Val 
            100                 105                 110         


Trp Ala Pro Tyr Gly His Leu Trp Arg Ser Leu Arg Arg Leu Thr Val 
        115                 120                 125             


Ile Glu Leu Phe Ser Ser Asn Ser Leu Gln Lys Ser Ser Phe Val Arg 
    130                 135                 140                 


Glu Gly Glu Ile Gly Asn Leu Leu Cys His Leu Phe Lys Phe Ser Asn 
145                 150                 155                 160 


Asn Gly Thr Gln Lys Val Glu Leu Lys Tyr Trp Phe Ser Leu Leu Ala 
                165                 170                 175     


Phe Asn Ile Met Met Lys Met Ile Ala Gly Lys Arg Cys Val Arg Asp 
            180                 185                 190         


Glu Val Ala Gly Met Glu Ala Gly Lys Gln Ile Leu Glu Asp Leu Arg 
        195                 200                 205             


Gly Lys Phe Val Ser Thr Thr Pro Leu Asn Ile Cys Asp Phe Phe Pro 
    210                 215                 220                 


Ile Leu Arg Trp Leu Gly Tyr Lys Gly Leu Lys Lys Ser Met Ile Arg 
225                 230                 235                 240 


Leu His Lys Lys Arg Asp Glu Phe Leu Gln Gly Leu Ile Asp Glu Phe 
                245                 250                 255     


Arg Ile Lys Ser Ser Ser Ser Ala Asn Thr Asn Ala Ile Met His Arg 
            260                 265                 270         


Val Gln Lys Val Thr Leu Ile Glu Lys Leu Leu Ser Leu Gln Glu Ala 
        275                 280                 285             


Glu Pro Asp Phe Tyr Ser Asp Asp Val Ile Lys Ser Ile Ile Leu Val 
    290                 295                 300                 


Thr Phe Val Ala Gly Thr Glu Thr Ser Ala Val Thr Ile Glu Trp Ala 
305                 310                 315                 320 


Met Ser Leu Leu Leu Asn Asn Pro Gln Ala Leu Val Lys Val Lys Ala 
                325                 330                 335     


Glu Ile Ser Ser His Val Gly Phe Glu Arg Leu Leu Asn Asp Ser Asp 
            340                 345                 350         


Leu Pro Lys Leu His Tyr Leu Arg Cys Val Ile Asn Glu Thr Leu Arg 
        355                 360                 365             


Leu Tyr Pro Pro Val Pro Leu Leu Leu Pro His Tyr Ser Ser Lys Asp 
    370                 375                 380                 


Cys Thr Leu Gly Gly Tyr Glu Ile Pro Gln Gly Thr Ile Leu Thr Val 
385                 390                 395                 400 


Asn Ala Trp Ala Met His Arg Asp Pro Lys Val Trp Glu Asp Pro Thr 
                405                 410                 415     


Lys Phe Asn Pro Glu Arg Phe Glu Val Val Gln Gly Glu Arg Glu Gly 
            420                 425                 430         


Phe Lys Phe Ile Pro Phe Gly Val Gly Arg Arg Ala Cys Pro Gly Ala 
        435                 440                 445             


Ala Met Ala Leu Arg Thr Val Ser Leu Ala Leu Gly Ala Leu Ile Gln 
    450                 455                 460                 


Cys Phe Glu Trp Glu Lys Val Gly Gln Glu Asn Met Glu Thr Ser Gln 
465                 470                 475                 480 


Gly Gly Leu Thr Leu Pro Lys Ala Gly Cys Leu Glu Ala Val Cys Ile 
                485                 490                 495     


Pro Arg Gln Asp Ser Ile Lys Leu Leu Ser Gln Leu Glu Ser His Cys 
            500                 505                 510         


Ser Asp 
        


<210>  23
<211>  1476
<212>  DNA
<213>  Camptotheca acuminata

<400>  23
atggatatgg atatggatac ggggctcgtc ttctgcataa tagttatcat cttctccatc       60

cttttcattt ccaaatttct attgccacaa aggaaaaact ttccaccgag tccactcgct      120

cttcccatac tcggccatct ccacctcctc aagaatccgg tgcacagggc gctccagtct      180

ctgtccaatc agcacggccc aatcctactg ctgcggttcg gatcccgccc tgtccttgtc      240

gtctcgtctc cgtcggccgc ccaacaatgc ttcaccgctg aaaacgacgt tatcttcgca      300

aaccgaccca acaccctcgg cggcaaacac ttcggctaca actacactac tcttgggtgg      360

tccccctacg gcgaccggtg gcgcgatctc cgccgtatca ccaccatcca aatcttctcc      420

tccaagagtc tccaggattc tgccacggtc cgaagagagg aggtccggtt tatcacccgc      480

cagctgtttc tgggatccga aggatcgacc cagaaggtga acgtgcaata tctggccttc      540

cagctgacct tcaacttgac gatgaagatg gtcgctggaa aaaggtgttc aagggcgaag      600

gagatattcg ctccgatgat gcggatgaat aaattagatt tcttaccctt tttgaagtgg      660

tttggtctca aaggatcgga gaatgggttg gtgaagttac agaaggcaag agatgcattc      720

ttgcagggct tgatcgatga gtatcgaccg gagagggaag tggacaagaa gaagacgatg      780

atcgagactt tgttgtcttt tcaagaagaa gaccctgaat ttttcacgga aaatacagtc      840

aagggcatca tggtgctact atttacagcg ggaacagata ctgtagctcg cacaatggaa      900

tgggcaatgt cacttctcct gaatcaccca gaagtactgc aaaaggccag aagcgaaata      960

gacaatcatg taaagccaca tcgtctgcta gaggactctg atctttccaa actaccttat     1020

ctacgttgca tcatcaacga aactcttcga ttatttcctg ttgcaccact tctcgtacct     1080

catttttcat cagaagactg cttagtagag agattccatg ttccacgagg aacaattttg     1140

ttggtcaatg cttgggccat tcatagggat cccagtgtct gggaagagcc caccaagttt     1200

aagccagaga ggtttgaagg aattgaaggg gaacgagaag ggttcaagtt cataccattt     1260

ggggtgggga ggaggggatg tcctggtgct ggcttggctc tgcgtttgct tgggttggcc     1320

ttggggacat tgattcagtg ctttgagtgg gaaagggttg ggtctgaatt ggtggacttg     1380

accgagggca gtgggataac tttgctaaag gttaagccat tagaggccat gtatagacct     1440

cgccggtcca tgaccgctct cctttctcaa ctttga                               1476


<210>  24
<211>  491
<212>  PRT
<213>  Camptotheca acuminata

<400>  24

Met Asp Met Asp Met Asp Thr Gly Leu Val Phe Cys Ile Ile Val Ile 
1               5                   10                  15      


Ile Phe Ser Ile Leu Phe Ile Ser Lys Phe Leu Leu Pro Gln Arg Lys 
            20                  25                  30          


Asn Phe Pro Pro Ser Pro Leu Ala Leu Pro Ile Leu Gly His Leu His 
        35                  40                  45              


Leu Leu Lys Asn Pro Val His Arg Ala Leu Gln Ser Leu Ser Asn Gln 
    50                  55                  60                  


His Gly Pro Ile Leu Leu Leu Arg Phe Gly Ser Arg Pro Val Leu Val 
65                  70                  75                  80  


Val Ser Ser Pro Ser Ala Ala Gln Gln Cys Phe Thr Ala Glu Asn Asp 
                85                  90                  95      


Val Ile Phe Ala Asn Arg Pro Asn Thr Leu Gly Gly Lys His Phe Gly 
            100                 105                 110         


Tyr Asn Tyr Thr Thr Leu Gly Trp Ser Pro Tyr Gly Asp Arg Trp Arg 
        115                 120                 125             


Asp Leu Arg Arg Ile Thr Thr Ile Gln Ile Phe Ser Ser Lys Ser Leu 
    130                 135                 140                 


Gln Asp Ser Ala Thr Val Arg Arg Glu Glu Val Arg Phe Ile Thr Arg 
145                 150                 155                 160 


Gln Leu Phe Leu Gly Ser Glu Gly Ser Thr Gln Lys Val Asn Val Gln 
                165                 170                 175     


Tyr Leu Ala Phe Gln Leu Thr Phe Asn Leu Thr Met Lys Met Val Ala 
            180                 185                 190         


Gly Lys Arg Cys Ser Arg Ala Lys Glu Ile Phe Ala Pro Met Met Arg 
        195                 200                 205             


Met Asn Lys Leu Asp Phe Leu Pro Phe Leu Lys Trp Phe Gly Leu Lys 
    210                 215                 220                 


Gly Ser Glu Asn Gly Leu Val Lys Leu Gln Lys Ala Arg Asp Ala Phe 
225                 230                 235                 240 


Leu Gln Gly Leu Ile Asp Glu Tyr Arg Pro Glu Arg Glu Val Asp Lys 
                245                 250                 255     


Lys Lys Thr Met Ile Glu Thr Leu Leu Ser Phe Gln Glu Glu Asp Pro 
            260                 265                 270         


Glu Phe Phe Thr Glu Asn Thr Val Lys Gly Ile Met Val Leu Leu Phe 
        275                 280                 285             


Thr Ala Gly Thr Asp Thr Val Ala Arg Thr Met Glu Trp Ala Met Ser 
    290                 295                 300                 


Leu Leu Leu Asn His Pro Glu Val Leu Gln Lys Ala Arg Ser Glu Ile 
305                 310                 315                 320 


Asp Asn His Val Lys Pro His Arg Leu Leu Glu Asp Ser Asp Leu Ser 
                325                 330                 335     


Lys Leu Pro Tyr Leu Arg Cys Ile Ile Asn Glu Thr Leu Arg Leu Phe 
            340                 345                 350         


Pro Val Ala Pro Leu Leu Val Pro His Phe Ser Ser Glu Asp Cys Leu 
        355                 360                 365             


Val Glu Arg Phe His Val Pro Arg Gly Thr Ile Leu Leu Val Asn Ala 
    370                 375                 380                 


Trp Ala Ile His Arg Asp Pro Ser Val Trp Glu Glu Pro Thr Lys Phe 
385                 390                 395                 400 


Lys Pro Glu Arg Phe Glu Gly Ile Glu Gly Glu Arg Glu Gly Phe Lys 
                405                 410                 415     


Phe Ile Pro Phe Gly Val Gly Arg Arg Gly Cys Pro Gly Ala Gly Leu 
            420                 425                 430         


Ala Leu Arg Leu Leu Gly Leu Ala Leu Gly Thr Leu Ile Gln Cys Phe 
        435                 440                 445             


Glu Trp Glu Arg Val Gly Ser Glu Leu Val Asp Leu Thr Glu Gly Ser 
    450                 455                 460                 


Gly Ile Thr Leu Leu Lys Val Lys Pro Leu Glu Ala Met Tyr Arg Pro 
465                 470                 475                 480 


Arg Arg Ser Met Thr Ala Leu Leu Ser Gln Leu 
                485                 490     


<210>  25
<211>  1179
<212>  DNA
<213>  Camptotheca acuminata

<400>  25
atggtcatta ctggcgaagc ctccgccgcc ttgctattgt tgaactcttc acatcgaaca       60

gccttcagaa gtcttccaac atccgtaaag aggaaattca taaccttctc tgtcacctct      120

tcaaattctc aaaaagtgga gttgaaatat tggttttttc gattgacatt caatattata      180

acaaggctgg tagctgggaa acaatgtgtt agagatgcac ttgcaggcac agatttgggg      240

aaacaaattc ttgaagacct cgaggggaag ttcggttcaa aaatgccatt gaatatgtgt      300

gatttctttc caattttgag gtggtttggt tacaaagggc tggagaaaag tctgacagtg      360

tggcacaagg agagagatga atttatgcaa ggtttgatag atgaggttag acgaaagaga      420

acctgttctg ccaatatcaa taatataaca aacagagcaa agacaacatt gattgaagct      480

ctcttgtccc tccaagaatc acaacctgac ttcttttctg atactatcat caaaagtatc      540

atttcagaca tgttttttgc agggccagaa acatcagcaa tcactctaga atgggcaatg      600

tcacttcttc taaatcatcc agaggtactg cgaaagttaa gagcagggat tgatgatcat      660

gttggacatg gacgccttct agatgactcg gatcttgtga agcttcccta tctccgttgc      720

atcatcaatg agaccctcag attatatcct ccaacaccac ttctattacc acactgttca      780

tctgaggatt gcactgtggg gggatatgaa ataccacaag gtacaatcct gtgggtgaat      840

gcttgggcca tgcatagaga tcccaagtta tgggaggagc caaccaagtt caagcctgag      900

agatttgaag gcatggaagg gagagaaagg aacaaattta ttccatttgg aattgggaga      960

agagcttgtc caggtgctag tatgggcatc cggacagttt cattggcttt gggtgcactt     1020

attcagtgtt ttgaatggga aaacgttggg cagaagaaaa tggagatgag ccaaggtcga     1080

cttactttgc ccaaggccga gtctttggag gctacgtgta ttccacgccc tagtgcaatg     1140

aaagtcctct cccagcttga agacacttgt ttcagttag                            1179


<210>  26
<211>  392
<212>  PRT
<213>  Camptotheca acuminata

<400>  26

Met Val Ile Thr Gly Glu Ala Ser Ala Ala Leu Leu Leu Leu Asn Ser 
1               5                   10                  15      


Ser His Arg Thr Ala Phe Arg Ser Leu Pro Thr Ser Val Lys Arg Lys 
            20                  25                  30          


Phe Ile Thr Phe Ser Val Thr Ser Ser Asn Ser Gln Lys Val Glu Leu 
        35                  40                  45              


Lys Tyr Trp Phe Phe Arg Leu Thr Phe Asn Ile Ile Thr Arg Leu Val 
    50                  55                  60                  


Ala Gly Lys Gln Cys Val Arg Asp Ala Leu Ala Gly Thr Asp Leu Gly 
65                  70                  75                  80  


Lys Gln Ile Leu Glu Asp Leu Glu Gly Lys Phe Gly Ser Lys Met Pro 
                85                  90                  95      


Leu Asn Met Cys Asp Phe Phe Pro Ile Leu Arg Trp Phe Gly Tyr Lys 
            100                 105                 110         


Gly Leu Glu Lys Ser Leu Thr Val Trp His Lys Glu Arg Asp Glu Phe 
        115                 120                 125             


Met Gln Gly Leu Ile Asp Glu Val Arg Arg Lys Arg Thr Cys Ser Ala 
    130                 135                 140                 


Asn Ile Asn Asn Ile Thr Asn Arg Ala Lys Thr Thr Leu Ile Glu Ala 
145                 150                 155                 160 


Leu Leu Ser Leu Gln Glu Ser Gln Pro Asp Phe Phe Ser Asp Thr Ile 
                165                 170                 175     


Ile Lys Ser Ile Ile Ser Asp Met Phe Phe Ala Gly Pro Glu Thr Ser 
            180                 185                 190         


Ala Ile Thr Leu Glu Trp Ala Met Ser Leu Leu Leu Asn His Pro Glu 
        195                 200                 205             


Val Leu Arg Lys Leu Arg Ala Gly Ile Asp Asp His Val Gly His Gly 
    210                 215                 220                 


Arg Leu Leu Asp Asp Ser Asp Leu Val Lys Leu Pro Tyr Leu Arg Cys 
225                 230                 235                 240 


Ile Ile Asn Glu Thr Leu Arg Leu Tyr Pro Pro Thr Pro Leu Leu Leu 
                245                 250                 255     


Pro His Cys Ser Ser Glu Asp Cys Thr Val Gly Gly Tyr Glu Ile Pro 
            260                 265                 270         


Gln Gly Thr Ile Leu Trp Val Asn Ala Trp Ala Met His Arg Asp Pro 
        275                 280                 285             


Lys Leu Trp Glu Glu Pro Thr Lys Phe Lys Pro Glu Arg Phe Glu Gly 
    290                 295                 300                 


Met Glu Gly Arg Glu Arg Asn Lys Phe Ile Pro Phe Gly Ile Gly Arg 
305                 310                 315                 320 


Arg Ala Cys Pro Gly Ala Ser Met Gly Ile Arg Thr Val Ser Leu Ala 
                325                 330                 335     


Leu Gly Ala Leu Ile Gln Cys Phe Glu Trp Glu Asn Val Gly Gln Lys 
            340                 345                 350         


Lys Met Glu Met Ser Gln Gly Arg Leu Thr Leu Pro Lys Ala Glu Ser 
        355                 360                 365             


Leu Glu Ala Thr Cys Ile Pro Arg Pro Ser Ala Met Lys Val Leu Ser 
    370                 375                 380                 


Gln Leu Glu Asp Thr Cys Phe Ser 
385                 390         


<210>  27
<211>  1527
<212>  DNA
<213>  Camptotheca acuminata

<400>  27
atggacacac tgtatacatc tcttgcatta atattagcca catatttctt catcaaacac       60

ttcgtcattc gcaagatcca aaacaaacca ccgagtccat tcccatcgct gcccattctc      120

ggccacctcc acctcttgaa gaagcccctc caccgaacct tggcccatat atcggcccgt      180

tacggcagta ttattctcct ccatttcgga tcacgtccag tcgtcgtagt ctcatctccc      240

tcagcagcgg aggaatgcct caccaagaac gacatcatct tcgccaatcg ccctcgcctc      300

ctcgccggaa aataccttgg ctacaaccat acctccctcg cgtgggcccc ctatagcgac      360

cactggcgga acctccgccg gatcgcgtcg ctcgaaattc tgtcatccca taggctgcag      420

atgttatccg gcatacgctc cgacgaggtg cgttcggtgg ttcgtagact ttcccgggct      480

tccgcagatg atcgggtgga catgaaaaag gtattcttcg agctgatgct taacgtgatg      540

atgagaatga ttgctggaaa gaggtattac ggcgagaacg tggcggaggt agagcagggg      600

acgcggtttc gcgagatcgt ggtggagaca ttcctgcttt ctggagccac aaacatgggg      660

gactttttgc ccattttgaa ttgggtggga gtgacgggat cggagaagcg gttgatggcg      720

ttgcagaaga agagagatgc gtttatgcag gaattgatag aagagcatag aagaggaatg      780

gggatcgata atggcgattc agatgagcag ggagagaaaa agaagacgat gattgcagtt      840

ttgttatccc tgcaagaaac ggaacctgat tattacaagg atgaaattat cagaggcatc      900

acgctggttc tgttagctgc aggaactgat acttcagctg ggaccatgga gtgggcactt      960

tcacttttgt tgaacaatcc agaagttcta aaaaaggcac agattgaaat tgataataag     1020

gttggacaaa accgtttggt caatgaatca gacatagctg acctccctta tctccgctgc     1080

atcctcaacg agacctttcg gatgttcccg gtaggcccat tattattacc tcatgaatca     1140

tcagaagatt gcacggtcgg aggtttccac atcccacgtg gcactatgct aatgattaat     1200

ttgtgggcca tacaaaatga ccccaagatt tgggaggacc caagaaagtt caagccagaa     1260

cggtttgaag gactggaagg ggtaagagat ggtttcaaat tgatgccttt tgggtcaggc     1320

aggagagggt gtcctgggga gggtctggcc atgcgaatgc ttggctttac attagggtca     1380

ttgattcagt gctttgattg ggaaagggtt ggcaaggact tggtggactt gactgaaggg     1440

cctgggctca ccatgcccaa ggctcaaccc ttggtggcta agtgccggcc acgtgcaaca     1500

atgttgaacc ttctgtctca aatttga                                         1527


<210>  28
<211>  508
<212>  PRT
<213>  Camptotheca acuminata

<400>  28

Met Asp Thr Leu Tyr Thr Ser Leu Ala Leu Ile Leu Ala Thr Tyr Phe 
1               5                   10                  15      


Phe Ile Lys His Phe Val Ile Arg Lys Ile Gln Asn Lys Pro Pro Ser 
            20                  25                  30          


Pro Phe Pro Ser Leu Pro Ile Leu Gly His Leu His Leu Leu Lys Lys 
        35                  40                  45              


Pro Leu His Arg Thr Leu Ala His Ile Ser Ala Arg Tyr Gly Ser Ile 
    50                  55                  60                  


Ile Leu Leu His Phe Gly Ser Arg Pro Val Val Val Val Ser Ser Pro 
65                  70                  75                  80  


Ser Ala Ala Glu Glu Cys Leu Thr Lys Asn Asp Ile Ile Phe Ala Asn 
                85                  90                  95      


Arg Pro Arg Leu Leu Ala Gly Lys Tyr Leu Gly Tyr Asn His Thr Ser 
            100                 105                 110         


Leu Ala Trp Ala Pro Tyr Ser Asp His Trp Arg Asn Leu Arg Arg Ile 
        115                 120                 125             


Ala Ser Leu Glu Ile Leu Ser Ser His Arg Leu Gln Met Leu Ser Gly 
    130                 135                 140                 


Ile Arg Ser Asp Glu Val Arg Ser Val Val Arg Arg Leu Ser Arg Ala 
145                 150                 155                 160 


Ser Ala Asp Asp Arg Val Asp Met Lys Lys Val Phe Phe Glu Leu Met 
                165                 170                 175     


Leu Asn Val Met Met Arg Met Ile Ala Gly Lys Arg Tyr Tyr Gly Glu 
            180                 185                 190         


Asn Val Ala Glu Val Glu Gln Gly Thr Arg Phe Arg Glu Ile Val Val 
        195                 200                 205             


Glu Thr Phe Leu Leu Ser Gly Ala Thr Asn Met Gly Asp Phe Leu Pro 
    210                 215                 220                 


Ile Leu Asn Trp Val Gly Val Thr Gly Ser Glu Lys Arg Leu Met Ala 
225                 230                 235                 240 


Leu Gln Lys Lys Arg Asp Ala Phe Met Gln Glu Leu Ile Glu Glu His 
                245                 250                 255     


Arg Arg Gly Met Gly Ile Asp Asn Gly Asp Ser Asp Glu Gln Gly Glu 
            260                 265                 270         


Lys Lys Lys Thr Met Ile Ala Val Leu Leu Ser Leu Gln Glu Thr Glu 
        275                 280                 285             


Pro Asp Tyr Tyr Lys Asp Glu Ile Ile Arg Gly Ile Thr Leu Val Leu 
    290                 295                 300                 


Leu Ala Ala Gly Thr Asp Thr Ser Ala Gly Thr Met Glu Trp Ala Leu 
305                 310                 315                 320 


Ser Leu Leu Leu Asn Asn Pro Glu Val Leu Lys Lys Ala Gln Ile Glu 
                325                 330                 335     


Ile Asp Asn Lys Val Gly Gln Asn Arg Leu Val Asn Glu Ser Asp Ile 
            340                 345                 350         


Ala Asp Leu Pro Tyr Leu Arg Cys Ile Leu Asn Glu Thr Phe Arg Met 
        355                 360                 365             


Phe Pro Val Gly Pro Leu Leu Leu Pro His Glu Ser Ser Glu Asp Cys 
    370                 375                 380                 


Thr Val Gly Gly Phe His Ile Pro Arg Gly Thr Met Leu Met Ile Asn 
385                 390                 395                 400 


Leu Trp Ala Ile Gln Asn Asp Pro Lys Ile Trp Glu Asp Pro Arg Lys 
                405                 410                 415     


Phe Lys Pro Glu Arg Phe Glu Gly Leu Glu Gly Val Arg Asp Gly Phe 
            420                 425                 430         


Lys Leu Met Pro Phe Gly Ser Gly Arg Arg Gly Cys Pro Gly Glu Gly 
        435                 440                 445             


Leu Ala Met Arg Met Leu Gly Phe Thr Leu Gly Ser Leu Ile Gln Cys 
    450                 455                 460                 


Phe Asp Trp Glu Arg Val Gly Lys Asp Leu Val Asp Leu Thr Glu Gly 
465                 470                 475                 480 


Pro Gly Leu Thr Met Pro Lys Ala Gln Pro Leu Val Ala Lys Cys Arg 
                485                 490                 495     


Pro Arg Ala Thr Met Leu Asn Leu Leu Ser Gln Ile 
            500                 505             


<210>  29
<211>  1542
<212>  DNA
<213>  Camptotheca acuminata

<400>  29
atggagaagt tgtactactg ccttgctctt ctactatcag ttcttctcat attcaaacat       60

ttcttccatc atagaacaaa gttaccacca agtccatttg ctcttcctat catcggccat      120

ctccatctca tcaggaattc tttccatcaa atactagagt gcttggcatc acaatatggt      180

ccaattttat tcctcaaagt tggaatccgc tctattcttg ttgtgtcgtc tccatccgtt      240

gttgaggaat gttttactaa gaatgatatt atatttgcaa accgtcctcg gaatatgctt      300

tcagatatct ctagttataa ttatagtacg atcgcatggg ctccatatgg tcattactgg      360

cggagcctcc gccgccttac tgttgttgaa ttcttctcat tgaatagcct ccagaagtct      420

tctaacatcc gtgaagagga aattcataac cttctctctc acctcttcaa attctcaaaa      480

agtggaactc aaaaagtcca gttgaaatat tggttctctc tattgacttt caatataata      540

acgaggctgg tagctgggaa gcggtgtgtt agagatgcgg ttgcaggcaa ggatttgggg      600

aaacaaattc ttgaagagct caaggggaag ttcgtttcga acatgccatt gaatatgtgt      660

gatttctttc caattttgag gtggtttggt tacaaagggc tggagaaaag tctgattatg      720

ttgctgcaga aggagagaga tgaattcttg cagggtttga tagatgaggt tagacgaaag      780

agaacctgtt ctgccaatat caatattgta acaaacagag caaagacaac attgattgaa      840

actctcttgt ccctccaaga atcagaacct gacttctttt ctgatactgt catcaaaagt      900

atcatttcag tcatgttttt tgcagggccg gaaacatcag caattactct ggaatgggca      960

atatcgcttc ttctaaataa tccagaggta ctggggaagt taagagcaga gattgatgat     1020

catgttggac atggacgcct tctagatgac tcggatcttg tgaagcttcc ctatctccgt     1080

tgcatcatca atgagaccct cagattatat cctccggcac cacttctatt accacgttgt     1140

tcatcagaag attgcactgt tgggggatat gaaataccac aaggtacaat tctgttggtg     1200

aatgcttggg ccatgcatag agatcccaag ttgtgggagg agccaaccaa gttcaagcct     1260

gagagatttg aaggcatgga agggagagaa gggtacaaat ttattccatt tggagttggg     1320

agaagagctt gtccaggtgc tagaatgggc atctggacag tttcactggc tttgggtgct     1380

cttgctcagt gttttgaatg ggaaaaggtt gtggaggata aaatggagat gagccagggt     1440

cgactaacta tgtccaaggc cgagtctttg gaggctctgt gtattccacg ccacagtgca     1500

atgacactcc tctcccagct tgaagacact tcctttattt ag                        1542


<210>  30
<211>  513
<212>  PRT
<213>  Camptotheca acuminata

<400>  30

Met Glu Lys Leu Tyr Tyr Cys Leu Ala Leu Leu Leu Ser Val Leu Leu 
1               5                   10                  15      


Ile Phe Lys His Phe Phe His His Arg Thr Lys Leu Pro Pro Ser Pro 
            20                  25                  30          


Phe Ala Leu Pro Ile Ile Gly His Leu His Leu Ile Arg Asn Ser Phe 
        35                  40                  45              


His Gln Ile Leu Glu Cys Leu Ala Ser Gln Tyr Gly Pro Ile Leu Phe 
    50                  55                  60                  


Leu Lys Val Gly Ile Arg Ser Ile Leu Val Val Ser Ser Pro Ser Val 
65                  70                  75                  80  


Val Glu Glu Cys Phe Thr Lys Asn Asp Ile Ile Phe Ala Asn Arg Pro 
                85                  90                  95      


Arg Asn Met Leu Ser Asp Ile Ser Ser Tyr Asn Tyr Ser Thr Ile Ala 
            100                 105                 110         


Trp Ala Pro Tyr Gly His Tyr Trp Arg Ser Leu Arg Arg Leu Thr Val 
        115                 120                 125             


Val Glu Phe Phe Ser Leu Asn Ser Leu Gln Lys Ser Ser Asn Ile Arg 
    130                 135                 140                 


Glu Glu Glu Ile His Asn Leu Leu Ser His Leu Phe Lys Phe Ser Lys 
145                 150                 155                 160 


Ser Gly Thr Gln Lys Val Gln Leu Lys Tyr Trp Phe Ser Leu Leu Thr 
                165                 170                 175     


Phe Asn Ile Ile Thr Arg Leu Val Ala Gly Lys Arg Cys Val Arg Asp 
            180                 185                 190         


Ala Val Ala Gly Lys Asp Leu Gly Lys Gln Ile Leu Glu Glu Leu Lys 
        195                 200                 205             


Gly Lys Phe Val Ser Asn Met Pro Leu Asn Met Cys Asp Phe Phe Pro 
    210                 215                 220                 


Ile Leu Arg Trp Phe Gly Tyr Lys Gly Leu Glu Lys Ser Leu Ile Met 
225                 230                 235                 240 


Leu Leu Gln Lys Glu Arg Asp Glu Phe Leu Gln Gly Leu Ile Asp Glu 
                245                 250                 255     


Val Arg Arg Lys Arg Thr Cys Ser Ala Asn Ile Asn Ile Val Thr Asn 
            260                 265                 270         


Arg Ala Lys Thr Thr Leu Ile Glu Thr Leu Leu Ser Leu Gln Glu Ser 
        275                 280                 285             


Glu Pro Asp Phe Phe Ser Asp Thr Val Ile Lys Ser Ile Ile Ser Val 
    290                 295                 300                 


Met Phe Phe Ala Gly Pro Glu Thr Ser Ala Ile Thr Leu Glu Trp Ala 
305                 310                 315                 320 


Ile Ser Leu Leu Leu Asn Asn Pro Glu Val Leu Gly Lys Leu Arg Ala 
                325                 330                 335     


Glu Ile Asp Asp His Val Gly His Gly Arg Leu Leu Asp Asp Ser Asp 
            340                 345                 350         


Leu Val Lys Leu Pro Tyr Leu Arg Cys Ile Ile Asn Glu Thr Leu Arg 
        355                 360                 365             


Leu Tyr Pro Pro Ala Pro Leu Leu Leu Pro Arg Cys Ser Ser Glu Asp 
    370                 375                 380                 


Cys Thr Val Gly Gly Tyr Glu Ile Pro Gln Gly Thr Ile Leu Leu Val 
385                 390                 395                 400 


Asn Ala Trp Ala Met His Arg Asp Pro Lys Leu Trp Glu Glu Pro Thr 
                405                 410                 415     


Lys Phe Lys Pro Glu Arg Phe Glu Gly Met Glu Gly Arg Glu Gly Tyr 
            420                 425                 430         


Lys Phe Ile Pro Phe Gly Val Gly Arg Arg Ala Cys Pro Gly Ala Arg 
        435                 440                 445             


Met Gly Ile Trp Thr Val Ser Leu Ala Leu Gly Ala Leu Ala Gln Cys 
    450                 455                 460                 


Phe Glu Trp Glu Lys Val Val Glu Asp Lys Met Glu Met Ser Gln Gly 
465                 470                 475                 480 


Arg Leu Thr Met Ser Lys Ala Glu Ser Leu Glu Ala Leu Cys Ile Pro 
                485                 490                 495     


Arg His Ser Ala Met Thr Leu Leu Ser Gln Leu Glu Asp Thr Ser Phe 
            500                 505                 510         


Ile 
    


<210>  31
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer sequence of pESC-Leu2d-32245

<400>  31
cactaaaggg cggccaacaa aatggagaag ttgtactact gc                          42


<210>  32
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence pESC-Leu2d-32245

<400>  32
cactaaaggg cggccaacaa aatggagaag ttgtactact gcct                        44


<210>  33
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence pESC-Leu2d-32236

<400>  33
cactaaaggg cggccaacaa aatggagaac ttgtactact gcct                        44


<210>  34
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence pESC-Leu2d-32236

<400>  34
atccatcgat actagacgga aacaagtgcc ttca                                   34


<210>  35
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence pESC-Leu2d-32245

<400>  35
cactaaaggg cggccaacaa aatggagaag ttgtactact gc                          42


<210>  36
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence pESC-Leu2d-32245

<400>  36
atccatcgat actagaataa aggaagtgtc ttcaagctgg                             40


<210>  37
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence pESC-Leu2d-32229

<400>  37
cactaaaggg cggccaacaa aatggagaac ttgtactact gcct                        44


<210>  38
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence pESC-Leu2d-32229

<400>  38
atccatcgat actagactga aacaagtgtc ttcaagctg                              39


