                         SEQUENCE LISTING

<110>  Century Therapeutics, Inc.
 
<120>  GENETICALLY ENGINEERED CELLS AND USES THEREOF

<130>  CNTY-001-WO-01

<150>  63/120,799
<151>  2020-12-03

<150>  63/120,948
<151>  2020-12-03

<150>  63/120,980
<151>  2020-12-03

<160>  95    

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  2
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FMC63 VH

<400>  2

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  3
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Whitlow Linker

<400>  3

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  4
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FMC63 VL

<400>  4

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
            100                 105         


<210>  5
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  5

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        35                  40                  45              


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    50                  55                  60                  


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
65                  70                  75                  80  


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
                85                  90                  95      


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            100                 105         


<210>  6
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  6

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  7
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FMC63 scFV

<400>  7

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys 
        115                 120                 125             


Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu 
            180                 185                 190         


His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr 
    210                 215                 220                 


Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Ile Thr 
                245 


<210>  8
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  8

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  9
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  9

Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn 
1               5                   10                  15      


Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly 
            20                  25                  30          


Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe 
        35                  40                  45              


Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu 
    50                  55                  60                  


Arg Asp Lys Val Thr Gln Leu Leu Pro Leu Asn Thr Asp Ala Tyr Leu 
65                  70                  75                  80  


Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
                85                  90                  


<210>  10
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  10

Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln 
1               5                   10                  15      


Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr 
            20                  25                  30          


Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln 
        35                  40                  45              


Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
    50                  55                  60          


<210>  11
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  11

Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His 
1               5                   10                  15      


Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln 
            20                  25                  30          


Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
        35                  40          


<210>  12
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  12

Thr Tyr Cys Phe Ala Pro Arg Cys Arg Glu Arg Arg Arg Asn Glu Arg 
1               5                   10                  15      


Leu Arg Arg Glu Ser Val Arg Pro Val 
            20                  25  


<210>  13
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  13

Lys Trp Lys Lys Lys Lys Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr 
1               5                   10                  15      


Asn Thr Met Glu Arg Glu Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys 
            20                  25                  30          


Ile His Ile Pro Glu Arg Ser Asp Glu Ala Gln Arg Val Phe Lys Ser 
        35                  40                  45              


Ser Lys Thr Ser Ser Cys Asp Lys Ser Asp Thr Cys Phe 
    50                  55                  60      


<210>  14
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  14

Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro 
1               5                   10                  15      


Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr 
            20                  25                  30          


Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
        35                  40                  45              


<210>  15
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  15

Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn 
1               5                   10                  15      


Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg 
            20                  25                  30          


Leu Thr Asp Val Thr Leu 
        35              


<210>  16
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gly Trp Ile Arg Gly Arg Arg Ser Arg His Ser Trp Glu Met Ser 
1               5                   10                  15      


Glu Phe His Asn Tyr Asn Leu Asp Leu Lys Lys Ser Asp Phe Ser Thr 
            20                  25                  30          


Arg Trp Gln Lys Gln Arg Cys Pro Val Val Lys Ser Lys Cys Arg Glu 
        35                  40                  45              


Asn Ala Ser 
    50      


<210>  17
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  17

Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys Val 
1               5                   10                  15      


Tyr Ile Asn Met Pro Gly Arg Gly 
            20                  


<210>  18
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  18

Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala 
1               5                   10                  15      


Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu 
            20                  25                  30          


Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg 
        35                  40                  45              


Pro Tyr Tyr Lys 
    50          


<210>  19
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  19

Trp Arg Arg Lys Arg Lys Glu Lys Gln Ser Glu Thr Ser Pro Lys Glu 
1               5                   10                  15      


Phe Leu Thr Ile Tyr Glu Asp Val Lys Asp Leu Lys Thr Arg Arg Asn 
            20                  25                  30          


His Glu Gln Glu Gln Thr Phe Pro Gly Gly Gly Ser Thr Ile Tyr Ser 
        35                  40                  45              


Met Ile Gln Ser Gln Ser Ser Ala Pro Thr Ser Gln Glu Pro Ala Tyr 
    50                  55                  60                  


Thr Leu Tyr Ser Leu Ile Gln Pro Ser Arg Lys Ser Gly Ser Arg Lys 
65                  70                  75                  80  


Arg Asn His Ser Pro Ser Phe Asn Ser Thr Ile Tyr Glu Val Ile Gly 
                85                  90                  95      


Lys Ser Gln Pro Lys Ala Gln Asn Pro Ala Arg Leu Ser Arg Lys Glu 
            100                 105                 110         


Leu Glu Asn Phe Asp Val Tyr Ser 
        115                 120 


<210>  20
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  20

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  21
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  21

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        35                  40                  45          


<210>  22
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  22

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro 
        35                  


<210>  23
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  23

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210>  24
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  24

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  25
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (GGGGS)3

<400>  25

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  26
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3

<400>  26

Gly Gly Ser Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser 
1               5                   10                  15      


Thr Gly Gly Ser 
            20  


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 4

<400>  27

Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210>  28
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 5

<400>  28

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10          


<210>  29
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 6

<400>  29

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


<210>  30
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 7

<400>  30

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  31
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 8

<400>  31

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  32
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 9

<400>  32

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  33
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 10

<400>  33

Ile Arg Pro Arg Ala Ile Gly Gly Ser Lys Pro Arg Val Ala 
1               5                   10                  


<210>  34
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 11

<400>  34

Gly Lys Gly Gly Ser Gly Lys Gly Gly Ser Gly Lys Gly Gly Ser 
1               5                   10                  15  


<210>  35
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 12

<400>  35

Gly Gly Lys Gly Ser Gly Gly Lys Gly Ser Gly Gly Lys Gly Ser 
1               5                   10                  15  


<210>  36
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 13

<400>  36

Gly Gly Gly Lys Ser Gly Gly Gly Lys Ser Gly Gly Gly Lys Ser 
1               5                   10                  15  


<210>  37
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 14

<400>  37

Gly Lys Gly Lys Ser Gly Lys Gly Lys Ser Gly Lys Gly Lys Ser 
1               5                   10                  15  


<210>  38
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 15

<400>  38

Gly Gly Gly Lys Ser Gly Gly Lys Gly Ser Gly Lys Gly Gly Ser 
1               5                   10                  15  


<210>  39
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 16

<400>  39

Gly Lys Pro Gly Ser Gly Lys Pro Gly Ser Gly Lys Pro Gly Ser 
1               5                   10                  15  


<210>  40
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 17

<400>  40

Gly Lys Pro Gly Ser Gly Lys Pro Gly Ser Gly Lys Pro Gly Ser Gly 
1               5                   10                  15      


Lys Pro Gly Ser 
            20  


<210>  41
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 18

<400>  41

Gly Lys Gly Lys Ser Gly Lys Gly Lys Ser Gly Lys Gly Lys Ser Gly 
1               5                   10                  15      


Lys Gly Lys Ser 
            20  


<210>  42
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 19

<400>  42

Ser Thr Ala Gly Asp Thr His Leu Gly Gly Glu Asp Phe Asp 
1               5                   10                  


<210>  43
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 20

<400>  43

Gly Glu Gly Gly Ser Gly Glu Gly Gly Ser Gly Glu Gly Gly Ser 
1               5                   10                  15  


<210>  44
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 21

<400>  44

Gly Gly Glu Gly Ser Gly Gly Glu Gly Ser Gly Gly Glu Gly Ser 
1               5                   10                  15  


<210>  45
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 22

<400>  45

Gly Glu Gly Glu Ser Gly Glu Gly Glu Ser Gly Glu Gly Glu Ser 
1               5                   10                  15  


<210>  46
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 23

<400>  46

Gly Gly Gly Glu Ser Gly Gly Glu Gly Ser Gly Glu Gly Gly Ser 
1               5                   10                  15  


<210>  47
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 24

<400>  47

Gly Glu Gly Glu Ser Gly Glu Gly Glu Ser Gly Glu Gly Glu Ser Gly 
1               5                   10                  15      


Glu Gly Glu Ser 
            20  


<210>  48
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 25

<400>  48

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  49
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 26

<400>  49

Pro Arg Gly Ala Ser Lys Ser Gly Ser Ala Ser Gln Thr Gly Ser Ala 
1               5                   10                  15      


Pro Gly Ser 
            


<210>  50
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 27

<400>  50

Gly Thr Ala Ala Ala Gly Ala Gly Ala Ala Gly Gly Ala Ala Ala Gly 
1               5                   10                  15      


Ala Ala Gly 
            


<210>  51
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 28

<400>  51

Gly Thr Ser Gly Ser Ser Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly 
            


<210>  52
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 29

<400>  52

Gly Lys Pro Gly Ser Gly Lys Pro Gly Ser Gly Lys Pro Gly Ser Gly 
1               5                   10                  15      


Lys Pro Gly Ser 
            20  


<210>  53
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 30

<400>  53

Gly Ser Gly Ser 
1               


<210>  54
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 31

<400>  54

Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10  


<210>  55
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 32

<400>  55

Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10                  15      


Ala Pro Ala Pro 
            20  


<210>  56
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 33

<400>  56

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Ala 
1               5                   10                  15      


Lys Glu Ala Ala Ala Ala Lys Glu Ala Ala Ala Ala Lys Ala Ala Ala 
            20                  25                  30          


<210>  57
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  57

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  58
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  58

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210>  59
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  59

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
            20                  25                  30          


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
        35                  40                  45              


Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
    50                  55                  60          


<210>  60
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  60

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro 
1               5                   10          


<210>  61
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD19 scFv CAR

<400>  61

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
145                 150                 155                 160 


Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu 
            180                 185                 190         


Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser 
        195                 200                 205             


Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln 
    210                 215                 220                 


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ile Glu Val Met Tyr 
            260                 265                 270         


Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His 
        275                 280                 285             


Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser 
    290                 295                 300                 


Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
305                 310                 315                 320 


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys 
                325                 330                 335     


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
            340                 345                 350         


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
        355                 360                 365             


Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  62
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD19 scFv CAR

<400>  62
atgctgctgc tggtcacatc tctgctgctg tgcgagctgc cccatcctgc ctttctgctg       60

atccccgaca tccagatgac ccagaccaca agcagcctgt ctgccagcct gggcgataga      120

gtgaccatca gctgtagagc cagccaggac atcagcaagt acctgaactg gtatcagcaa      180

aagcccgacg gcaccgtgaa gctgctgatc taccacacca gcagactgca cagcggcgtg      240

ccaagcagat tttctggcag cggctctggc accgactaca gcctgacaat cagcaacctg      300

gaacaagagg atatcgctac ctacttctgc cagcaaggca acaccctgcc ttacaccttt      360

ggcggaggca ccaagctgga aatcaccggc tctacaagcg gcagcggcaa acctggatct      420

ggcgagggat ctaccaaggg cgaagtgaaa ctgcaagagt ctggccctgg actggtggcc      480

ccatctcagt ctctgagcgt gacctgtaca gtcagcggag tgtccctgcc tgattacggc      540

gtgtcctgga tcagacagcc tcctcggaaa ggcctggaat ggctgggagt gatctggggc      600

agcgagacaa cctactacaa cagcgccctg aagtcccggc tgaccatcat caaggacaac      660

tccaagagcc aggtgttcct gaagatgaac agcctgcaga ccgacgacac cgccatctac      720

tattgcgcca agcactacta ctacggcggc agctacgcca tggattattg gggccagggc      780

accagcgtga ccgtgtctag catcgaagtg atgtaccctc caccttacct ggacaacgag      840

aagtccaacg gcaccatcat ccacgtgaag ggcaagcacc tgtgtccttc tccactgttc      900

cccggaccta gcaagccttt ctgggtgctc gttgttgttg gcggcgtgct ggcctgttac      960

agcctgctgg ttaccgtggc cttcatcatc ttttgggtcc gaagcaagcg gagccggctg     1020

ctgcactccg actacatgaa catgacccct agacggcccg gaccaaccag aaagcactac     1080

cagccttacg ctcctcctag agacttcgcc gcctaccggt ccagagtgaa gttcagcaga     1140

tccgccgatg ctcccgccta tcagcagggc caaaaccagc tgtacaacga gctgaacctg     1200

gggagaagag aagagtacga cgtgctggac aagcggagag gcagagatcc tgaaatgggc     1260

ggcaagccca gacggaagaa tcctcaagag ggcctgtata atgagctgca gaaagacaag     1320

atggccgagg cctacagcga gatcggaatg aagggcgagc gcagaagagg caagggacac     1380

gatggactgt accagggact gagcaccgcc accaaggata cctatgacgc cctgcacatg     1440

caggccctgc ctccaagatg a                                               1461


<210>  63
<211>  1724
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAG Promoter

<400>  63
attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat       60

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      120

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      180

tccattgacg tcaatgggtg gactatttac ggtaaactgc ccacttggca gtacatcaag      240

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      300

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      360

tcatcgctat taccatgggt cgaggtgagc cccacgttct gcttcactct ccccatctcc      420

cccccctccc cacccccaat tttgtattta tttatttttt aattattttg tgcagcgatg      480

ggggcggggg gggggggggc gcgcgccagg cggggcgggg cggggcgagg ggcggggcgg      540

ggcgaggcgg agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa agtttccttt      600

tatggcgagg cggcggcggc ggcggcccta taaaaagcga agcgcgcggc gggcgggagt      660

cgctgcgttg ccttcgcccc gtgccccgct ccgcgccgcc tcgcgccgcc cgccccggct      720

ctgactgacc gcgttactcc cacaggtgag cgggcgggac ggcccttctc ctccgggctg      780

taattagcgc ttggtttaat gacggctcgt ttcttttctg tggctgcgtg aaagccttaa      840

agggctccgg gagggccctt tgtgcggggg ggagcggctc ggggggtgcg tgcgtgtgtg      900

tgtgcgtggg gagcgccgcg tgcggcccgc gctgcccggc ggctgtgagc gctgcgggcg      960

cggcgcgggg ctttgtgcgc tccgcgtgtg cgcgagggga gcgcggccgg gggcggtgcc     1020

ccgcggtgcg ggggggctgc gaggggaaca aaggctgcgt gcggggtgtg tgcgtggggg     1080

ggtgagcagg gggtgtgggc gcggcggtcg ggctgtaacc cccccctgca cccccctccc     1140

cgagttgctg agcacggccc ggcttcgggt gcggggctcc gtgcggggcg tggcgcgggg     1200

ctcgccgtgc cgggcggggg gtggcggcag gtgggggtgc cgggcggggc ggggccgcct     1260

cgggccgggg agggctcggg ggaggggcgc ggcggccccg gagcgccggc ggctgtcgag     1320

gcgcggcgag ccgcagccat tgccttttat ggtaatcgtg cgagagggcg cagggacttc     1380

ctttgtccca aatctggcgg agccgaaatc tgggaggcgc cgccgcaccc cctctagcgg     1440

gcgcgggcga agcggtgcgg cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg     1500

tcgccgcgcc gccgtcccct tctccatctc cagcctcggg gctgccgcag ggggacggct     1560

gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc ggcgggatat     1620

ctacgaagcg gccgccctct gctaaccatg ttcatgcctt cttctttttc ctacagctcc     1680

tgggcaacgt gctggttatt gtgctgtctc atcattttgg caaa                      1724


<210>  64
<211>  121
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SV40 terminator/polyadenylation

<400>  64
aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca       60

aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct      120

t                                                                      121


<210>  65
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  65

His Ser Leu Lys Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg Gly 
1               5                   10                  15      


Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln Phe Val 
            20                  25                  30          


Arg Phe Asp Asn Asp Ala Ala Ser Pro Arg Met Val Pro Arg Ala Pro 
        35                  40                  45              


Trp Met Glu Gln Glu Gly Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser 
    50                  55                  60                  


Ala Arg Asp Thr Ala Gln Ile Phe Arg Val Asn Leu Arg Thr Leu Arg 
65                  70                  75                  80  


Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Trp Met 
                85                  90                  95      


His Gly Cys Glu Leu Gly Pro Asp Gly Arg Phe Leu Arg Gly Tyr Glu 
            100                 105                 110         


Gln Phe Ala Tyr Asp Gly Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu 
        115                 120                 125             


Arg Ser Trp Thr Ala Val Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys 
    130                 135                 140                 


Ser Asn Asp Ala Ser Glu Ala Glu His Gln Arg Ala Tyr Leu Glu Asp 
145                 150                 155                 160 


Thr Cys Val Glu Trp Leu His Lys Tyr Leu Glu Lys Gly Lys Glu Thr 
                165                 170                 175     


Leu Leu His Leu Glu Pro Pro Lys Thr His Val Thr His His Pro Ile 
            180                 185                 190         


Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro 
        195                 200                 205             


Ala Glu Ile Thr Leu Thr Trp Gln Gln Asp Gly Glu Gly His Thr Gln 
    210                 215                 220                 


Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln 
225                 230                 235                 240 


Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr 
                245                 250                 255     


Cys His Val Gln His Glu Gly Leu Pro Glu Pro Val Thr Leu Arg Trp 
            260                 265                 270         


Lys Pro Ala Ser Gln Pro Thr Ile Pro Ile Val Gly Ile Ile Ala Gly 
        275                 280                 285             


Leu Val Leu Leu Gly Ser Val Val Ser Gly Ala Val Val Ala Ala Val 
    290                 295                 300                 


Ile Trp Arg Lys Lys Ser Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys 
305                 310                 315                 320 


Ala Glu Trp Ser Asp Ser Ala Gln Gly Ser Glu Ser His Ser Leu 
                325                 330                 335 


<210>  66
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-G signal-Peptide-B2M-HLA-E

<400>  66

Met Val Val Met Ala Pro Arg Thr Leu Phe Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Thr Leu Thr Glu Thr Trp Ala Val Met Ala Pro Arg Thr Leu Ile 
            20                  25                  30          


Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40                  45              


Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser 
    50                  55                  60                  


Arg His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val 
65                  70                  75                  80  


Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly 
                85                  90                  95      


Glu Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp 
            100                 105                 110         


Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys 
        115                 120                 125             


Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys 
    130                 135                 140                 


Ile Val Lys Trp Asp Arg Asp Met Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gly Ser His Ser Leu Lys Tyr Phe His 
                165                 170                 175     


Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser Val 
            180                 185                 190         


Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala Ala 
        195                 200                 205             


Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly Ser 
    210                 215                 220                 


Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln Ile 
225                 230                 235                 240 


Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu 
                245                 250                 255     


Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly Pro 
            260                 265                 270         


Asp Gly Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly Lys 
        275                 280                 285             


Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val Asp 
    290                 295                 300                 


Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu Ala 
305                 310                 315                 320 


Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu His 
                325                 330                 335     


Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro Pro 
            340                 345                 350         


Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr Leu 
        355                 360                 365             


Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp 
    370                 375                 380                 


Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu Thr 
385                 390                 395                 400 


Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val 
                405                 410                 415     


Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly 
            420                 425                 430         


Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro Thr 
        435                 440                 445             


Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser Val 
    450                 455                 460                 


Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser Ser 
465                 470                 475                 480 


Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser Ala 
                485                 490                 495     


Gln Gly Ser Glu Ser His Ser Leu 
            500                 


<210>  67
<211>  1515
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HLA-G signal-Peptide-B2M-HLA-E

<400>  67
atggtggtca tggcccctag aacactgttc ctgctgctgt ctggcgccct gacactgaca       60

gagacatggg ccgtgatggc ccccagaacc ctgatcctgg gcggcggtgg ttcaggcgga      120

ggaggttcag gaggaggggg tagtggaggt ggtggttcta tccagcggac ccctaagatc      180

caggtgtaca gcagacaccc cgccgagaac ggcaagagca acttcctgaa ctgctacgtg      240

tccggctttc accccagcga cattgaggtg gacctgctga agaacggcga gcggatcgag      300

aaggtggaac acagcgatct gagcttcagc aaggactggt ccttctacct gctgtactac      360

accgagttca cccctaccga gaaggacgag tacgcctgca gagtgaacca cgtgacactg      420

agccagccta agatcgtgaa gtgggatcgc gatatgggcg gaggcggatc tggtggcgga      480

ggaagtggcg gcggaggatc tggctcccac tccttgaagt atttccacac ttccgtgtcc      540

cggcccggcc gcggggagcc ccgcttcatc tctgtgggct acgtggacga cacccagttc      600

gtgcgcttcg acaacgacgc cgcgagtccg aggatggtgc cgcgggcgcc gtggatggag      660

caggaggggt cagagtattg ggaccgggag acacggagcg ccagggacac cgcacagatt      720

ttccgagtga atctgcggac gctgcgcggc tactacaatc agagcgaggc cgggtctcac      780

accctgcagt ggatgcatgg ctgcgagctg gggcccgacg ggcgcttcct ccgcgggtat      840

gaacagttcg cctacgacgg caaggattat ctcaccctga atgaggacct gcgctcctgg      900

accgcggtgg acacggcggc tcagatctcc gagcaaaagt caaatgatgc ctctgaggcg      960

gagcaccaga gagcctacct ggaagacaca tgcgtggagt ggctccacaa atacctggag     1020

aaggggaagg agacgctgct tcacctggag cccccaaaga cacacgtgac tcaccacccc     1080

atctctgacc atgaggccac cctgaggtgc tgggccctgg gcttctaccc tgcggagatc     1140

acactgacct ggcagcagga tggggagggc catacccagg acacggagct cgtggagacc     1200

aggcctgcag gggatggaac cttccagaag tgggcagctg tggtggtgcc ttctggagag     1260

gagcagagat acacgtgcca tgtgcagcat gaggggctac ccgagcccgt caccctgaga     1320

tggaagccgg cttcccagcc caccatcccc atcgtgggca tcattgctgg cctggttctc     1380

cttggatctg tggtctctgg agctgtggtt gctgctgtga tatggaggaa gaagagctca     1440

ggtggaaaag gagggagcta ctctaaggct gagtggagcg acagtgccca ggggtctgag     1500

tctcacagct tgtaa                                                      1515


<210>  68
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  68

His Ser Met Arg Tyr Phe Ser Ala Ala Val Ser Arg Pro Gly Arg Gly 
1               5                   10                  15      


Glu Pro Arg Phe Ile Ala Met Gly Tyr Val Asp Asp Thr Gln Phe Val 
            20                  25                  30          


Arg Phe Asp Ser Asp Ser Ala Cys Pro Arg Met Glu Pro Arg Ala Pro 
        35                  40                  45              


Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Glu Glu Glu Thr Arg Asn 
    50                  55                  60                  


Thr Lys Ala His Ala Gln Thr Asp Arg Met Asn Leu Gln Thr Leu Arg 
65                  70                  75                  80  


Gly Tyr Tyr Asn Gln Ser Glu Ala Ser Ser His Thr Leu Gln Trp Met 
                85                  90                  95      


Ile Gly Cys Asp Leu Gly Ser Asp Gly Arg Leu Leu Arg Gly Tyr Glu 
            100                 105                 110         


Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Leu Ala Leu Asn Glu Asp Leu 
        115                 120                 125             


Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Ser Lys Arg Lys 
    130                 135                 140                 


Cys Glu Ala Ala Asn Val Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly 
145                 150                 155                 160 


Thr Cys Val Glu Trp Leu His Arg Tyr Leu Glu Asn Gly Lys Glu Met 
                165                 170                 175     


Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His His Pro Val 
            180                 185                 190         


Phe Asp Tyr Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro 
        195                 200                 205             


Ala Glu Ile Ile Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln 
    210                 215                 220                 


Asp Val Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln 
225                 230                 235                 240 


Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr 
                245                 250                 255     


Cys His Val Gln His Glu Gly Leu Pro Glu Pro Leu Met Leu Arg Trp 
            260                 265                 270         


Lys Gln Ser Ser Leu Pro Thr Ile Pro Ile Met Gly Ile Val Ala Gly 
        275                 280                 285             


Leu Val Val Leu Ala Ala Val Val Thr Gly Ala Ala Val Ala Ala Val 
    290                 295                 300                 


Leu Trp Arg Lys Lys Ser Ser Asp 
305                 310         


<210>  69
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-G signal-Peptide-B2M-HLA-G

<400>  69

Met Val Val Met Ala Pro Arg Thr Leu Phe Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Thr Leu Thr Glu Thr Trp Ala Arg Ile Ile Pro Arg His Leu Gln 
            20                  25                  30          


Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro 
        35                  40                  45              


Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu Asn Gly Lys Ser Asn 
    50                  55                  60                  


Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val 
65                  70                  75                  80  


Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser Asp 
                85                  90                  95      


Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu 
            100                 105                 110         


Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val 
        115                 120                 125             


Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser His 
145                 150                 155                 160 


Ser Met Arg Tyr Phe Ser Ala Ala Val Ser Arg Pro Gly Arg Gly Glu 
                165                 170                 175     


Pro Arg Phe Ile Ala Met Gly Tyr Val Asp Asp Thr Gln Phe Val Arg 
            180                 185                 190         


Phe Asp Ser Asp Ser Ala Cys Pro Arg Met Glu Pro Arg Ala Pro Trp 
        195                 200                 205             


Val Glu Gln Glu Gly Pro Glu Tyr Trp Glu Glu Glu Thr Arg Asn Thr 
    210                 215                 220                 


Lys Ala His Ala Gln Thr Asp Arg Met Asn Leu Gln Thr Leu Arg Gly 
225                 230                 235                 240 


Tyr Tyr Asn Gln Ser Glu Ala Ser Ser His Thr Leu Gln Trp Met Ile 
                245                 250                 255     


Gly Cys Asp Leu Gly Ser Asp Gly Arg Leu Leu Arg Gly Tyr Glu Gln 
            260                 265                 270         


Tyr Ala Tyr Asp Gly Lys Asp Tyr Leu Ala Leu Asn Glu Asp Leu Arg 
        275                 280                 285             


Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Ser Lys Arg Lys Cys 
    290                 295                 300                 


Glu Ala Ala Asn Val Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly Thr 
305                 310                 315                 320 


Cys Val Glu Trp Leu His Arg Tyr Leu Glu Asn Gly Lys Glu Met Leu 
                325                 330                 335     


Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His His Pro Val Phe 
            340                 345                 350         


Asp Tyr Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala 
        355                 360                 365             


Glu Ile Ile Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp 
    370                 375                 380                 


Val Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys 
385                 390                 395                 400 


Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys 
                405                 410                 415     


His Val Gln His Glu Gly Leu Pro Glu Pro Leu Met Leu Arg Trp Lys 
            420                 425                 430         


Gln Ser Ser Leu Pro Thr Ile Pro Ile Met Gly Ile Val Ala Gly Leu 
        435                 440                 445             


Val Val Leu Ala Ala Val Val Thr Gly Ala Ala Val Ala Ala Val Leu 
    450                 455                 460                 


Trp Arg Lys Lys Ser Ser Asp 
465                 470     


<210>  70
<211>  1422
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HLA-G signal-Peptide-B2M-HLA-G

<400>  70
gccaccatgg tggtcatggc gccccgaacc ctcttcctgc tgctctcggg ggccctgacc       60

ctgaccgaga cctgggcgcg gatcattccc cgacatctgc aactgggagg cggcggttca      120

ggagggggcg gatcgatcca acgcaccccc aagatccagg tctactccag acacccggcc      180

gaaaacggaa agtcgaactt cctgaactgc tatgtgtcag gattccaccc gtccgacatc      240

gaggtggacc tcctgaagaa cggcgaacgc attgagaagg tcgagcactc cgatctgtcg      300

ttctccaagg actggtcctt ctaccttctc tactataccg aattcacccc gaccgagaag      360

gacgaatacg cctgccgggt caaccacgtg accctgagcc agccaaagat cgtgaaatgg      420

gaccgcgata tgggaggagg aggttccggc ggaggaggaa gcggaggcgg aggttccggc      480

tcccactcca tgaggtattt cagcgccgcc gtgtcccggc ctggccgcgg agagcctcgc      540

ttcatcgcca tgggatacgt ggacgacacc cagttcgtca gattcgacag cgacagcgcc      600

tgtcctcgga tggaacctag agcaccttgg gtcgagcaag agggccctga gtactgggaa      660

gaagagacac ggaacaccaa ggctcacgcc cagaccgaca gaatgaacct gcagaccctg      720

cggggctact acaatcagtc tgaggccagc agccatactc tgcagtggat gatcggctgc      780

gatctgggct ctgatggcag actgctgaga ggctacgagc agtacgccta cgacggcaag      840

gattatctgg ccctgaacga ggacctgcgg tcttggacag ctgccgatac agccgctcag      900

atcagcaaga gaaagtgcga ggccgccaat gtggccgaac agagaagggc ttacctggaa      960

ggcacctgtg tggaatggct gcacagatac ctggaaaacg gcaaagagat gctgcagcgg     1020

gccgatcctc ctaagacaca tgtgacccac catcctgtgt tcgactacga ggccacactg     1080

agatgttggg ccctgggctt ttaccctgcc gagatcatcc tgacctggca gcgagatggc     1140

gaggatcaga cccaggatgt ggaactggtg gaaaccagac ctgccggcga cggcaccttt     1200

cagaaatggg ctgctgtggt ggtgcccagc ggagaggaac agagatacac ctgtcacgtg     1260

cagcacgagg gactgcctga acctctgatg ctgagatgga agcagagcag cctgcctaca     1320

atccccatca tgggaatcgt ggccggactg gtggttctgg ccgctgttgt tacaggtgct     1380

gcagtggctg ccgtgctgtg gcggaagaaa agcagcgact ga                        1422


<210>  71
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated EGFR

<400>  71

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Gly Val Arg Lys Cys Lys Lys Cys 
            20                  25                  30          


Glu Gly Pro Cys Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe 
        35                  40                  45              


Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn 
    50                  55                  60                  


Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg 
65                  70                  75                  80  


Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp 
                85                  90                  95      


Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala 
            100                 105                 110         


Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile 
        115                 120                 125             


Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val 
    130                 135                 140                 


Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser 
145                 150                 155                 160 


Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn 
                165                 170                 175     


Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys 
            180                 185                 190         


Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val 
        195                 200                 205             


Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg 
    210                 215                 220                 


Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp 
225                 230                 235                 240 


Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser 
                245                 250                 255     


Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile 
            260                 265                 270         


Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr 
        275                 280                 285             


Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly 
    290                 295                 300                 


Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys 
305                 310                 315                 320 


His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu 
                325                 330                 335     


Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly 
            340                 345                 350         


Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly 
        355                 360                 365             


Leu Phe Met 
    370     


<210>  72
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210>  73
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A

<400>  73

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  74
<211>  556
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tEGFR-P2A-IL15

<400>  74

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Gly Val Arg Lys Cys Lys Lys Cys 
            20                  25                  30          


Glu Gly Pro Cys Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe 
        35                  40                  45              


Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn 
    50                  55                  60                  


Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg 
65                  70                  75                  80  


Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp 
                85                  90                  95      


Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala 
            100                 105                 110         


Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile 
        115                 120                 125             


Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val 
    130                 135                 140                 


Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser 
145                 150                 155                 160 


Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn 
                165                 170                 175     


Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys 
            180                 185                 190         


Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val 
        195                 200                 205             


Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg 
    210                 215                 220                 


Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp 
225                 230                 235                 240 


Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser 
                245                 250                 255     


Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile 
            260                 265                 270         


Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr 
        275                 280                 285             


Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly 
    290                 295                 300                 


Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys 
305                 310                 315                 320 


His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu 
                325                 330                 335     


Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly 
            340                 345                 350         


Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly 
        355                 360                 365             


Leu Phe Met Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
    370                 375                 380                 


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Arg Ile Ser Lys Pro 
385                 390                 395                 400 


His Leu Arg Ser Ile Ser Ile Gln Cys Tyr Leu Cys Leu Leu Leu Asn 
                405                 410                 415     


Ser His Phe Leu Thr Glu Ala Gly Ile His Val Phe Ile Leu Gly Cys 
            420                 425                 430         


Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile 
        435                 440                 445             


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
    450                 455                 460                 


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
465                 470                 475                 480 


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
                485                 490                 495     


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
            500                 505                 510         


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
        515                 520                 525             


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
    530                 535                 540                 


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
545                 550                 555     


<210>  75
<211>  1668
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  tEGFR-P2A-IL15

<400>  75
atgaggccct caggcactgc cggggccgcc ctcctggccc tgttagccgc tttgtgtcca       60

gcaagccgcg ccggagtgcg gaaatgtaag aaatgcgaag gaccctgccg gaaggtatgc      120

aacggcattg ggattggcga attcaaggac agcctgagca ttaatgctac aaacatcaag      180

cactttaaga attgcaccag cattagcggc gatctgcata tactgccagt ggctttccga      240

ggcgactctt ttactcatac ccctccgctg gaccctcaag agctggacat tctcaagact      300

gtgaaggaaa ttacggggtt tctgctcatt caggcctggc ctgaaaaccg cacggatttg      360

catgcctttg agaatctgga aataatcaga ggccggacga aacagcatgg ccagttcagc      420

ctcgcggtcg tctctttgaa tattacgtca ctcggcctca ggtccctcaa agagatttct      480

gatggcgatg tcatcatctc tggtaataag aatctgtgtt acgcaaatac catcaattgg      540

aagaagctct ttgggacctc aggtcaaaag actaaaatta tctccaaccg cggcgagaac      600

agctgtaagg ctacaggcca ggtttgccac gcgctctgct ccccagaggg ttgctggggg      660

cctgagccaa gggattgcgt ttcatgtcgc aacgtgtctc ggggcagaga atgcgtggat      720

aaatgtaacc tcttagaggg cgaacctcgc gagtttgttg agaactcaga atgtatacag      780

tgccaccccg aatgtcttcc tcaggccatg aatatcacat gcaccggacg cggaccagac      840

aactgtatcc aatgtgctca ctacattgac ggacctcatt gtgtgaaaac atgccccgca      900

ggagttatgg gagaaaacaa caccctcgtt tggaaatatg ccgatgcagg tcacgtatgt      960

cacctgtgcc acccaaactg cacttatggg tgcaccgggc cgggcctgga ggggtgccct     1020

acgaatggac caaaaattcc cagtattgca actgggatgg tcggggcact gttgttgctg     1080

cttgtggttg ccctcgggat aggcctgttt atgtctggct ccggcgccac caatttcagc     1140

ctgctgaaac aggcaggcga cgtcgaagaa aatccaggac caatgcgaat atcaaaacca     1200

cacttgcgca gcatttctat acagtgctat ttgtgcttgt tgctgaactc tcacttcctc     1260

acagaggctg ggatacacgt tttcatactt ggatgttttt cagctgggct gccgaagaca     1320

gaggcgaatt gggtgaatgt aatttcagac ctcaagaaga tcgaggatct catccagtcc     1380

atgcacatcg acgctactct gtacacagag agcgatgtcc acccttcttg taaggttacc     1440

gccatgaaat gcttcctttt ggaactccaa gtcatctcat tggaatcagg ggatgcgtcc     1500

attcatgaca ccgtggaaaa cctgataata ctggctaaca acagcttgtc aagtaatggg     1560

aatgttactg agtccggttg taaagaatgt gaagagctgg aggagaagaa cattaaggaa     1620

tttttgcaat cttttgtaca tattgttcag atgtttatta acacaagc                  1668


<210>  76
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210>  77
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal Sequence

<400>  77

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  78
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polivy epitope

<400>  78

Ala Arg Ser Glu Asp Arg Tyr Arg Asn Pro Lys Gly Ser Ala Cys Ser 
1               5                   10                  15      


Arg Ile Trp Gln Ser 
            20      


<210>  79
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD79b-P2A-IL15

<400>  79

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Cys Ala Arg Ser Glu Asp Arg Tyr Arg Asn Pro Lys Gly Ser 
            20                  25                  30          


Ala Cys Ser Arg Ile Trp Gln Ser Thr Thr Thr Pro Ala Pro Arg Pro 
        35                  40                  45              


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
    50                  55                  60                  


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
65                  70                  75                  80  


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
                85                  90                  95      


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Ala Thr Asn Phe Ser Leu 
            100                 105                 110         


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Arg Ile 
        115                 120                 125             


Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr Leu Cys Leu 
    130                 135                 140                 


Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His Val Phe Ile 
145                 150                 155                 160 


Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val 
                165                 170                 175     


Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met 
            180                 185                 190         


His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys 
        195                 200                 205             


Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser 
    210                 215                 220                 


Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile 
225                 230                 235                 240 


Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser 
                245                 250                 255     


Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe 
            260                 265                 270         


Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
        275                 280                 285         


<210>  80
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD20 mimitope

<400>  80

Ala Cys Pro Tyr Ala Asn Pro Ser Leu Cys 
1               5                   10  


<210>  81
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD20 mimitope-P2A-IL15

<400>  81

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Cys Ala Cys Pro Tyr Ala Asn Pro Ser Leu Cys Gly Gly Gly 
            20                  25                  30          


Gly Ser Gly Gly Gly Gly Ser Ala Cys Pro Tyr Ala Asn Pro Ser Leu 
        35                  40                  45              


Cys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
    50                  55                  60                  


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
65                  70                  75                  80  


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
                85                  90                  95      


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
            100                 105                 110         


Val Ile Thr Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
        115                 120                 125             


Glu Glu Asn Pro Gly Pro Met Arg Ile Ser Lys Pro His Leu Arg Ser 
    130                 135                 140                 


Ile Ser Ile Gln Cys Tyr Leu Cys Leu Leu Leu Asn Ser His Phe Leu 
145                 150                 155                 160 


Thr Glu Ala Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly 
                165                 170                 175     


Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys 
            180                 185                 190         


Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr 
        195                 200                 205             


Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys 
    210                 215                 220                 


Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser 
225                 230                 235                 240 


Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu 
                245                 250                 255     


Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu 
            260                 265                 270         


Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile 
        275                 280                 285             


Val Gln Met Phe Ile Asn Thr Ser 
    290                 295     


<210>  82
<211>  176
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ErbB epitope

<400>  82

Glu Gly Leu Ala Cys His Gln Leu Cys Ala Arg Gly His Cys Trp Gly 
1               5                   10                  15      


Pro Gly Pro Thr Gln Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln 
            20                  25                  30          


Glu Cys Val Glu Glu Cys Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr 
        35                  40                  45              


Val Asn Ala Arg His Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln 
    50                  55                  60                  


Asn Gly Ser Val Thr Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala 
65                  70                  75                  80  


Cys Ala His Tyr Lys Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser 
                85                  90                  95      


Gly Val Lys Pro Asp Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp 
            100                 105                 110         


Glu Glu Gly Ala Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys 
        115                 120                 125             


Val Asp Leu Asp Asp Lys Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro 
    130                 135                 140                 


Leu Thr Ser Ile Ile Ser Ala Val Val Gly Ile Leu Leu Val Val Val 
145                 150                 155                 160 


Leu Gly Val Val Phe Gly Ile Leu Ile Gly Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


<210>  83
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ErbB epitope-P2A-IL15

<400>  83

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Cys Glu Gly Leu Ala Cys His Gln Leu Cys Ala Arg Gly His 
            20                  25                  30          


Cys Trp Gly Pro Gly Pro Thr Gln Cys Val Asn Cys Ser Gln Phe Leu 
        35                  40                  45              


Arg Gly Gln Glu Cys Val Glu Glu Cys Arg Val Leu Gln Gly Leu Pro 
    50                  55                  60                  


Arg Glu Tyr Val Asn Ala Arg His Cys Leu Pro Cys His Pro Glu Cys 
65                  70                  75                  80  


Gln Pro Gln Asn Gly Ser Val Thr Cys Phe Gly Pro Glu Ala Asp Gln 
                85                  90                  95      


Cys Val Ala Cys Ala His Tyr Lys Asp Pro Pro Phe Cys Val Ala Arg 
            100                 105                 110         


Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Tyr Met Pro Ile Trp Lys 
        115                 120                 125             


Phe Pro Asp Glu Glu Gly Ala Cys Gln Pro Cys Pro Ile Asn Cys Thr 
    130                 135                 140                 


His Ser Cys Val Asp Leu Asp Asp Lys Gly Cys Pro Ala Glu Gln Arg 
145                 150                 155                 160 


Ala Ser Pro Leu Thr Ser Ile Ile Ser Ala Val Val Gly Ile Leu Leu 
                165                 170                 175     


Val Val Val Leu Gly Val Val Phe Gly Ile Leu Ile Gly Gly Gly Gly 
            180                 185                 190         


Ser Gly Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
        195                 200                 205             


Glu Glu Asn Pro Gly Pro Met Arg Ile Ser Lys Pro His Leu Arg Ser 
    210                 215                 220                 


Ile Ser Ile Gln Cys Tyr Leu Cys Leu Leu Leu Asn Ser His Phe Leu 
225                 230                 235                 240 


Thr Glu Ala Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly 
                245                 250                 255     


Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys 
            260                 265                 270         


Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr 
        275                 280                 285             


Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys 
    290                 295                 300                 


Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser 
305                 310                 315                 320 


Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu 
                325                 330                 335     


Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu 
            340                 345                 350         


Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile 
        355                 360                 365             


Val Gln Met Phe Ile Asn Thr Ser 
    370                 375     


<210>  84
<211>  1000
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CIITA targeting left homology arm

<400>  84
acaggaggta accatttaac aagaaagcag agtgatgtta gattatagca agatactgtt       60

gactgtagaa ggctctgagg ctagagagct gctttctata aaacagagtg atcatatatt      120

agaagaggtg ttaaagacat gttcacacca agctgagact tcctccttga taccaccagg      180

aggatgggca gagactggaa aagacactaa ctttctccct atgggagtca gtattattta      240

gcatcacttt ggcgggtcac cccaaaccat ctgactacaa gggtaccata tttgggttaa      300

cactcttttg gtataattta tgttttagtc caatgtcttg ggatgaaaat gacaggtggg      360

ccacttatga tctccagaga aattcagggc aatttggtgt gggagtaggc atggtagagg      420

agagcagcat ctaagaagtc cccagcagag gctctcagct tgtcttgagg catctgggcg      480

gagggctatg atactggccc catcctgcag aaggtggcag atattggcag ctggcaccag      540

tgcggttcca ttgtgatcat catttctgaa cgtcagactg ttgaaggttc ccccaacaga      600

ctttctgtgc aactttctgt cttcaccaaa ttcagtccac agtaaggaag tgaaattaat      660

ttcagaggtg tggggagggc ttaagggagt gtggtaaaat tagagggtgt tcagaaacag      720

aaatctgacc gcttggggcc accttgcagg gagagttttt ttgatgatcc ctcacttgtt      780

tctttgcatg ttggcttagc ttggcgggct cccaactggt gactggttag tgatgaggct      840

agtgatgagg ctgtgtgctt ctgagctggg catccgaagg catccttggg gaagctgagg      900

gcacgaggag gggctgccag actccgggag ctgctgcctg gctgggattc ctacacaatg      960

cgttgcctgg ctccacgccc tgctgggtcc tacctgtcag                           1000


<210>  85
<211>  1000
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CIITA targeting right homology arm

<400>  85
agccccaagg taaaaaggcc gggaaagcat cttaatttag cgtgcagtct cagctggtcc       60

tgccattcca gataaacaga gaaaccattc tgaattgggg atgggggtga ggatgggaac      120

aggagtctgt gtcctgctgg ggcaggccat tggaagatgt gaaagagttg tctatttcct      180

tccaccggag ggagacttca ggtcagccag gtgtctggag tatgaaccat gtatcagcac      240

cgaaaggttc tagaagtcag actttcgggc agtgtgtcac taactctcag catgctggcc      300

tggctcggcc cacagcaagg tcttctcgcc tccctttggg taaatactga ggggtgcctc      360

tgcaggacgg gacctctgcc agactccact ccatacccag agaagcaggg aaaccaaaat      420

tggagtcagc cttgaggtgt agctgttgag ccctcagcag ctggggagag ctggcggatg      480

ctgccctccc cccagtttcc taatggtgtt gtttaaaaag ggtcagggga cgggggaaca      540

gatggtggga agagcacagt gcagacacct ggcaccggct ctgaaggcag catggcagct      600

acaccgttgg ctgggaaggg tgtgcccctg aagaagtcgt ttacattctc gagtcaattt      660

tcctggagtg tacaatggac ctgtgggaaa gcctgtatga aagggtaatg atgagggacc      720

tagcacagtg tccaatattt tataggaact ggaattgagc tcataggagc tcaattttat      780

tggcattgct gttgttggat ggttaaaggg gtggtatccc ttttctcaga ctcccctgaa      840

atgtatggtt tgctttgaac ccagagactg atgacaggtc tgccggtgtg gttgggtgca      900

gccttaagtt gctacgggaa agtgttggag ggggagaagt cagaggtaac cttgccccct      960

ccctcaattc cagatgagga aattcaggcc tgaaaaggga                           1000


<210>  86
<211>  6604
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CIITA targeting plasmid

<400>  86
cgcctgacct ctcgaacagg aggtaaccat ttaacaagaa agcagagtga tgttagatta       60

tagcaagata ctgttgactg tagaaggctc tgaggctaga gagctgcttt ctataaaaca      120

gagtgatcat atattagaag aggtgttaaa gacatgttca caccaagctg agacttcctc      180

cttgatacca ccaggaggat gggcagagac tggaaaagac actaactttc tccctatggg      240

agtcagtatt atttagcatc actttggcgg gtcaccccaa accatctgac tacaagggta      300

ccatatttgg gttaacactc ttttggtata atttatgttt tagtccaatg tcttgggatg      360

aaaatgacag gtgggccact tatgatctcc agagaaattc agggcaattt ggtgtgggag      420

taggcatggt agaggagagc agcatctaag aagtccccag cagaggctct cagcttgtct      480

tgaggcatct gggcggaggg ctatgatact ggccccatcc tgcagaaggt ggcagatatt      540

ggcagctggc accagtgcgg ttccattgtg atcatcattt ctgaacgtca gactgttgaa      600

ggttccccca acagactttc tgtgcaactt tctgtcttca ccaaattcag tccacagtaa      660

ggaagtgaaa ttaatttcag aggtgtgggg agggcttaag ggagtgtggt aaaattagag      720

ggtgttcaga aacagaaatc tgaccgcttg gggccacctt gcagggagag tttttttgat      780

gatccctcac ttgtttcttt gcatgttggc ttagcttggc gggctcccaa ctggtgactg      840

gttagtgatg aggctagtga tgaggctgtg tgcttctgag ctgggcatcc gaaggcatcc      900

ttggggaagc tgagggcacg aggaggggct gccagactcc gggagctgct gcctggctgg      960

gattcctaca caatgcgttg cctggctcca cgccctgctg ggtcctacct gtcagtcgag     1020

aaggatctgc gatcgctccg gtgcccgtca gtgggcagag cgcacatcgc ccacagtccc     1080

cgagaagttg gggggagggg tcggcaattg aacgggtgcc tagagaaggt ggcgcggggt     1140

aaactgggaa agtgatgtcg tgtactggct ccgccttttt cccgagggtg ggggagaacc     1200

gtatataagt gcagtagtcg ccgtgaacgt tctttttcgc aacgggtttg ccgccagaac     1260

acagctgaag cttcgagggg ctcgcatctc tccttcacgc gcccgccgcc ctacctgagg     1320

ccgccatcca cgccggttga gtcgcgttct gccgcctccc gcctgtggtg cctcctgaac     1380

tgcgtccgcc gtctaggtaa gtttaaagct caggtcgaga ccgggccttt gtccggcgct     1440

cccttggagc ctacctagac tcagccggct ctccacgctt tgcctgaccc tgcttgctca     1500

actctacgtc tttgtttcgt tttctgttct gcgccgttac agatccaagc tgtgaccggc     1560

gcctacgccg ccaccatgag gccctcaggc actgccgggg ccgccctcct ggccctgtta     1620

gccgctttgt gtccagcaag ccgcgccgga gtgcggaaat gtaagaaatg cgaaggaccc     1680

tgccggaagg tatgcaacgg cattgggatt ggcgaattca aggacagcct gagcattaat     1740

gctacaaaca tcaagcactt taagaattgc accagcatta gcggcgatct gcatatactg     1800

ccagtggctt tccgaggcga ctcttttact catacccctc cgctggaccc tcaagagctg     1860

gacattctca agactgtgaa ggaaattacg gggtttctgc tcattcaggc ctggcctgaa     1920

aaccgcacgg atttgcatgc ctttgagaat ctggaaataa tcagaggccg gacgaaacag     1980

catggccagt tcagcctcgc ggtcgtctct ttgaatatta cgtcactcgg cctcaggtcc     2040

ctcaaagaga tttctgatgg cgatgtcatc atctctggta ataagaatct gtgttacgca     2100

aataccatca attggaagaa gctctttggg acctcaggtc aaaagactaa aattatctcc     2160

aaccgcggcg agaacagctg taaggctaca ggccaggttt gccacgcgct ctgctcccca     2220

gagggttgct gggggcctga gccaagggat tgcgtttcat gtcgcaacgt gtctcggggc     2280

agagaatgcg tggataaatg taacctctta gagggcgaac ctcgcgagtt tgttgagaac     2340

tcagaatgta tacagtgcca ccccgaatgt cttcctcagg ccatgaatat cacatgcacc     2400

ggacgcggac cagacaactg tatccaatgt gctcactaca ttgacggacc tcattgtgtg     2460

aaaacatgcc ccgcaggagt tatgggagaa aacaacaccc tcgtttggaa atatgccgat     2520

gcaggtcacg tatgtcacct gtgccaccca aactgcactt atgggtgcac cgggccgggc     2580

ctggaggggt gccctacgaa tggaccaaaa attcccagta ttgcaactgg gatggtcggg     2640

gcactgttgt tgctgcttgt ggttgccctc gggataggcc tgtttatgtc tggctccggc     2700

gccaccaatt tcagcctgct gaaacaggca ggcgacgtcg aagaaaatcc aggaccaatg     2760

cgaatatcaa aaccacactt gcgcagcatt tctatacagt gctatttgtg cttgttgctg     2820

aactctcact tcctcacaga ggctgggata cacgttttca tacttggatg tttttcagct     2880

gggctgccga agacagaggc gaattgggtg aatgtaattt cagacctcaa gaagatcgag     2940

gatctcatcc agtccatgca catcgacgct actctgtaca cagagagcga tgtccaccct     3000

tcttgtaagg ttaccgccat gaaatgcttc cttttggaac tccaagtcat ctcattggaa     3060

tcaggggatg cgtccattca tgacaccgtg gaaaacctga taatactggc taacaacagc     3120

ttgtcaagta atgggaatgt tactgagtcc ggttgtaaag aatgtgaaga gctggaggag     3180

aagaacatta aggaattttt gcaatctttt gtacatattg ttcagatgtt tattaacaca     3240

agctgataaa acttgtttat tgcagcttat aatggttaca aataaagcaa tagcatcaca     3300

aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc caaactcatc     3360

aatgtatctt atcatgtctg taaggatcag ccccaaggta aaaaggccgg gaaagcatct     3420

taatttagcg tgcagtctca gctggtcctg ccattccaga taaacagaga aaccattctg     3480

aattggggat gggggtgagg atgggaacag gagtctgtgt cctgctgggg caggccattg     3540

gaagatgtga aagagttgtc tatttccttc caccggaggg agacttcagg tcagccaggt     3600

gtctggagta tgaaccatgt atcagcaccg aaaggttcta gaagtcagac tttcgggcag     3660

tgtgtcacta actctcagca tgctggcctg gctcggccca cagcaaggtc ttctcgcctc     3720

cctttgggta aatactgagg ggtgcctctg caggacggga cctctgccag actccactcc     3780

atacccagag aagcagggaa accaaaattg gagtcagcct tgaggtgtag ctgttgagcc     3840

ctcagcagct ggggagagct ggcggatgct gccctccccc cagtttccta atggtgttgt     3900

ttaaaaaggg tcaggggacg ggggaacaga tggtgggaag agcacagtgc agacacctgg     3960

caccggctct gaaggcagca tggcagctac accgttggct gggaagggtg tgcccctgaa     4020

gaagtcgttt acattctcga gtcaattttc ctggagtgta caatggacct gtgggaaagc     4080

ctgtatgaaa gggtaatgat gagggaccta gcacagtgtc caatatttta taggaactgg     4140

aattgagctc ataggagctc aattttattg gcattgctgt tgttggatgg ttaaaggggt     4200

ggtatccctt ttctcagact cccctgaaat gtatggtttg ctttgaaccc agagactgat     4260

gacaggtctg ccggtgtggt tgggtgcagc cttaagttgc tacgggaaag tgttggaggg     4320

ggagaagtca gaggtaacct tgccccctcc ctcaattcca gatgaggaaa ttcaggcctg     4380

aaaagggaga tccaggctag gtggaggctc agtgatgata agtctgcgat ggtggatgca     4440

tgtgtcatgg tcatagctgt ttcctgtgtg aaattgttat ccgctcagag ggcacaatcc     4500

tattccgcgc tatccgacaa tctccaagac attaggtgga gttcagttcg gcgtatggca     4560

tatgtcgctg gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag     4620

gccgcgttgc tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga     4680

cgctcaagtc agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct     4740

ggaagctccc tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc     4800

tttctccctt cgggaagcgt ggcgctttct catagctcac gctgtaggta tctcagttcg     4860

gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc     4920

tgcgccttat ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca     4980

ctggcagcag ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag     5040

ttcttgaagt ggtggcctaa ctacggctac actagaagaa cagtatttgg tatctgcgct     5100

ctgctgaagc cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc     5160

accgctggta gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga     5220

tctcaagaag atcctttgat cttttctacg gggtctgacg ctctattcaa caaagccgcc     5280

gtcccgtcaa gtcagcgtaa atgggtaggg ggcttcaaat cgtcctcgtg ataccaattc     5340

ggagcctgct tttttgtaca aacttgttga taatggcaat tcaaggatct tcacctagat     5400

ccttttaaat taaaaatgaa gttttaaatc aatctaaagt atatatgagt aaacttggtc     5460

tgacagttac caatgcttaa tcagtgaggc acctatctca gcgatctgtc tatttcgttc     5520

atccatagtt gcctgactcc ccgtcgtgta gataactacg atacgggagg gcttaccatc     5580

tggccccagt gctgcaatga taccgcgaga gccacgctca ccggctccag atttatcagc     5640

aataaaccag ccagccggaa gggccgagcg cagaagtggt cctgcaactt tatccgcctc     5700

catccagtct attaattgtt gccgggaagc tagagtaagt agttcgccag ttaatagttt     5760

gcgcaacgtt gttgccattg ctacaggcat cgtggtgtca cgctcgtcgt ttggtatggc     5820

ttcattcagc tccggttccc aacgatcaag gcgagttaca tgatccccca tgttgtgcaa     5880

aaaagcggtt agctccttcg gtcctccgat cgttgtcaga agtaagttgg ccgcagtgtt     5940

atcactcatg gttatggcag cactgcataa ttctcttact gtcatgccat ccgtaagatg     6000

cttttctgtg actggtgagt actcaaccaa gtcattctga gaatagtgta tgcggcgacc     6060

gagttgctct tgcccggcgt caatacggga taataccgcg ccacatagca gaactttaaa     6120

agtgctcatc attggaaaac gttcttcggg gcgaaaactc tcaaggatct taccgctgtt     6180

gagatccagt tcgatgtaac ccactcgtgc acccaactga tcttcagcat cttttacttt     6240

caccagcgtt tctgggtgag caaaaacagg aaggcaaaat gccgcaaaaa agggaataag     6300

ggcgacacgg aaatgttgaa tactcatact cttccttttt caatattatt gaagcattta     6360

tcagggttat tgtctcatga gcggatacat atttgaatgt atttagaaaa ataaacaaat     6420

aggggttccg cgcacatttc cccgaaaagt gccagatacc tgaaacaaaa cccatcgtac     6480

ggccaaggaa gtctccaata actgtgatcc accacaagcg ccagggtttt cccagtcacg     6540

acgttgtaaa acgacggcca gtcatgcata atccgcacgc atctggaata aggaagtgcc     6600

attc                                                                  6604


<210>  87
<211>  1042
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting left homology arm

<400>  87
gcatataaaa cctcagcaga aataaagagg ttttgttgtt tggtaagaac ataccttggg       60

ttggttgggc acggtggctc gtgcctgtaa tcccaacact ttgggaggcc aaggcaggct      120

gatcacttga agttgggagt tcaagaccag cctggccaac atggtgaaat cccgtctcta      180

ctgaaaatac aaaaattaac caggcatggt ggtgtgtgcc tgtagtccca ggaatcactt      240

gaacccagga ggcggaggtt gcagtgagct gagatctcac cactgcacac tgcactccag      300

cctgggcaat ggaatgagat tccatcccaa aaaataaaaa aataaaaaaa taaagaacat      360

accttgggtt gatccactta ggaacctcag ataataacat ctgccacgta tagagcaatt      420

gctatgtccc aggcactcta ctagacactt catacagttt agaaaatcag atgggtgtag      480

atcaaggcag gagcaggaac caaaaagaaa ggcataaaca taagaaaaaa aatggaaggg      540

gtggaaacag agtacaataa catgagtaat ttgatggggg ctattatgaa ctgagaaatg      600

aactttgaaa agtatcttgg ggccaaatca tgtagactct tgagtgatgt gttaaggaat      660

gctatgagtg ctgagagggc atcagaagtc cttgagagcc tccagagaaa ggctcttaaa      720

aatgcagcgc aatctccagt gacagaagat actgctagaa atctgctaga aaaaaaacaa      780

aaaaggcatg tatagaggaa ttatgaggga aagataccaa gtcacggttt attcttcaaa      840

atggaggtgg cttgttggga aggtggaagc tcatttggcc agagtggaaa tggaattggg      900

agaaatcgat gaccaaatgt aaacacttgg tgcctgatat agcttgacac caagttagcc      960

ccaagtgaaa taccctggca atattaatgt gtcttttccc gatattcctc aggtactcca     1020

aagattcagg tttactcacg tc                                              1042


<210>  88
<211>  1023
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting right homology arm

<400>  88
atccagcaga gaatggaaag tcaaatttcc tgaattgcta tgtgtctggg tttcatccat       60

ccgacattga agttgactta ctgaagaatg gagagagaat tgaaaaagtg gagcattcag      120

acttgtcttt cagcaaggac tggtctttct atctcttgta ctacactgaa ttcaccccca      180

ctgaaaaaga tgagtatgcc tgccgtgtga accatgtgac tttgtcacag cccaagatag      240

ttaagtgggg taagtcttac attcttttgt aagctgctga aagttgtgta tgagtagtca      300

tatcataaag ctgctttgat ataaaaaagg tctatggcca tactaccctg aatgagtccc      360

atcccatctg atataaacaa tctgcatatt gggattgtca gggaatgttc ttaaagatca      420

gattagtggc acctgctgag atactgatgc acagcatggt ttctgaacca gtagtttccc      480

tgcagttgag cagggagcag cagcagcact tgcacaaata catatacact cttaacactt      540

cttacctact ggcttcctct agcttttgtg gcagcttcag gtatatttag cactgaacga      600

acatctcaag aaggtatagg cctttgtttg taagtcctgc tgtcctagca tcctataatc      660

ctggacttct ccagtacttt ctggctggat tggtatctga ggctagtagg aagggcttgt      720

tcctgctggg tagctctaaa caatgtattc atgggtagga acagcagcct attctgccag      780

ccttatttct aaccatttta gacatttgtt agtacatggt attttaaaag taaaacttaa      840

tgtcttcctt ttttttctcc actgtctttt tcatagatcg agacatgtaa gcagcatcat      900

ggaggtaagt ttttgacctt gagaaaatgt ttttgtttca ctgtcctgag gactatttat      960

agacagctct aacatgataa ccctcactat gtggagaaca ttgacagagt aacattttag     1020

cag                                                                   1023


<210>  89
<211>  7813
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M Targeting Plasmid

<400>  89
gcatataaaa cctcagcaga aataaagagg ttttgttgtt tggtaagaac ataccttggg       60

ttggttgggc acggtggctc gtgcctgtaa tcccaacact ttgggaggcc aaggcaggct      120

gatcacttga agttgggagt tcaagaccag cctggccaac atggtgaaat cccgtctcta      180

ctgaaaatac aaaaattaac caggcatggt ggtgtgtgcc tgtagtccca ggaatcactt      240

gaacccagga ggcggaggtt gcagtgagct gagatctcac cactgcacac tgcactccag      300

cctgggcaat ggaatgagat tccatcccaa aaaataaaaa aataaaaaaa taaagaacat      360

accttgggtt gatccactta ggaacctcag ataataacat ctgccacgta tagagcaatt      420

gctatgtccc aggcactcta ctagacactt catacagttt agaaaatcag atgggtgtag      480

atcaaggcag gagcaggaac caaaaagaaa ggcataaaca taagaaaaaa aatggaaggg      540

gtggaaacag agtacaataa catgagtaat ttgatggggg ctattatgaa ctgagaaatg      600

aactttgaaa agtatcttgg ggccaaatca tgtagactct tgagtgatgt gttaaggaat      660

gctatgagtg ctgagagggc atcagaagtc cttgagagcc tccagagaaa ggctcttaaa      720

aatgcagcgc aatctccagt gacagaagat actgctagaa atctgctaga aaaaaaacaa      780

aaaaggcatg tatagaggaa ttatgaggga aagataccaa gtcacggttt attcttcaaa      840

atggaggtgg cttgttggga aggtggaagc tcatttggcc agagtggaaa tggaattggg      900

agaaatcgat gaccaaatgt aaacacttgg tgcctgatat agcttgacac caagttagcc      960

ccaagtgaaa taccctggca atattaatgt gtcttttccc gatattcctc aggtactcca     1020

aagattcagg tttactcacg tcggcctcca acgcgtagat ctattgatta ttgactagtt     1080

attaatagta atcaattacg gggtcattag ttcatagccc atatatggag ttccgcgtta     1140

cataacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc ccattgacgt     1200

caataatgac gtatgttccc atagtaacgc caatagggac tttccattga cgtcaatggg     1260

tggactattt acggtaaact gcccacttgg cagtacatca agtgtatcat atgccaagta     1320

cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc cagtacatga     1380

ccttatggga ctttcctact tggcagtaca tctacgtatt agtcatcgct attaccatgg     1440

gtcgaggtga gccccacgtt ctgcttcact ctccccatct cccccccctc cccaccccca     1500

attttgtatt tatttatttt ttaattattt tgtgcagcga tgggggcggg gggggggggg     1560

gcgcgcgcca ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc ggagaggtgc     1620

ggcggcagcc aatcagagcg gcgcgctccg aaagtttcct tttatggcga ggcggcggcg     1680

gcggcggccc tataaaaagc gaagcgcgcg gcgggcggga gtcgctgcgt tgccttcgcc     1740

ccgtgccccg ctccgcgccg cctcgcgccg cccgccccgg ctctgactga ccgcgttact     1800

cccacaggtg agcgggcggg acggcccttc tcctccgggc tgtaattagc gcttggttta     1860

atgacggctc gtttcttttc tgtggctgcg tgaaagcctt aaagggctcc gggagggccc     1920

tttgtgcggg ggggagcggc tcggggggtg cgtgcgtgtg tgtgtgcgtg gggagcgccg     1980

cgtgcggccc gcgctgcccg gcggctgtga gcgctgcggg cgcggcgcgg ggctttgtgc     2040

gctccgcgtg tgcgcgaggg gagcgcggcc gggggcggtg ccccgcggtg cgggggggct     2100

gcgaggggaa caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca gggggtgtgg     2160

gcgcggcggt cgggctgtaa cccccccctg cacccccctc cccgagttgc tgagcacggc     2220

ccggcttcgg gtgcggggct ccgtgcgggg cgtggcgcgg ggctcgccgt gccgggcggg     2280

gggtggcggc aggtgggggt gccgggcggg gcggggccgc ctcgggccgg ggagggctcg     2340

ggggaggggc gcggcggccc cggagcgccg gcggctgtcg aggcgcggcg agccgcagcc     2400

attgcctttt atggtaatcg tgcgagaggg cgcagggact tcctttgtcc caaatctggc     2460

ggagccgaaa tctgggaggc gccgccgcac cccctctagc gggcgcgggc gaagcggtgc     2520

ggcgccggca ggaaggaaat gggcggggag ggccttcgtg cgtcgccgcg ccgccgtccc     2580

cttctccatc tccagcctcg gggctgccgc agggggacgg ctgccttcgg gggggacggg     2640

gcagggcggg gttcggcttc tggcgtgtga ccggcgggat atctacgaag cggccgccct     2700

ctgctaacca tgttcatgcc ttcttctttt tcctacagct cctgggcaac gtgctggtta     2760

ttgtgctgtc tcatcatttt ggcaaagtcg acgccaccat ggtggtcatg gcccctagaa     2820

cactgttcct gctgctgtct ggcgccctga cactgacaga gacatgggcc gtgatggccc     2880

ccagaaccct gatcctgggc ggcggtggtt caggcggagg aggttcagga ggagggggta     2940

gtggaggtgg tggttctatc cagcggaccc ctaagatcca ggtgtacagc agacaccccg     3000

ccgagaacgg caagagcaac ttcctgaact gctacgtgtc cggctttcac cccagcgaca     3060

ttgaggtgga cctgctgaag aacggcgagc ggatcgagaa ggtggaacac agcgatctga     3120

gcttcagcaa ggactggtcc ttctacctgc tgtactacac cgagttcacc cctaccgaga     3180

aggacgagta cgcctgcaga gtgaaccacg tgacactgag ccagcctaag atcgtgaagt     3240

gggatcgcga tatgggcgga ggcggatctg gtggcggagg aagtggcggc ggaggatctg     3300

gctcccactc cttgaagtat ttccacactt ccgtgtcccg gcccggccgc ggggagcccc     3360

gcttcatctc tgtgggctac gtggacgaca cccagttcgt gcgcttcgac aacgacgccg     3420

cgagtccgag gatggtgccg cgggcgccgt ggatggagca ggaggggtca gagtattggg     3480

accgggagac acggagcgcc agggacaccg cacagatttt ccgagtgaat ctgcggacgc     3540

tgcgcggcta ctacaatcag agcgaggccg ggtctcacac cctgcagtgg atgcatggct     3600

gcgagctggg gcccgacggg cgcttcctcc gcgggtatga acagttcgcc tacgacggca     3660

aggattatct caccctgaat gaggacctgc gctcctggac cgcggtggac acggcggctc     3720

agatctccga gcaaaagtca aatgatgcct ctgaggcgga gcaccagaga gcctacctgg     3780

aagacacatg cgtggagtgg ctccacaaat acctggagaa ggggaaggag acgctgcttc     3840

acctggagcc cccaaagaca cacgtgactc accaccccat ctctgaccat gaggccaccc     3900

tgaggtgctg ggccctgggc ttctaccctg cggagatcac actgacctgg cagcaggatg     3960

gggagggcca tacccaggac acggagctcg tggagaccag gcctgcaggg gatggaacct     4020

tccagaagtg ggcagctgtg gtggtgcctt ctggagagga gcagagatac acgtgccatg     4080

tgcagcatga ggggctaccc gagcccgtca ccctgagatg gaagccggct tcccagccca     4140

ccatccccat cgtgggcatc attgctggcc tggttctcct tggatctgtg gtctctggag     4200

ctgtggttgc tgctgtgata tggaggaaga agagctcagg tggaaaagga gggagctact     4260

ctaaggctga gtggagcgac agtgcccagg ggtctgagtc tcacagcttg taatgaagcg     4320

gccgcgactc tagatcataa tcagccatac cacatttgta gaggttttac ttgctttaaa     4380

aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg ttgttgttaa     4440

cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa     4500

taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta     4560

tcatgtctga tccagcagag aatggaaagt caaatttcct gaattgctat gtgtctgggt     4620

ttcatccatc cgacattgaa gttgacttac tgaagaatgg agagagaatt gaaaaagtgg     4680

agcattcaga cttgtctttc agcaaggact ggtctttcta tctcttgtac tacactgaat     4740

tcacccccac tgaaaaagat gagtatgcct gccgtgtgaa ccatgtgact ttgtcacagc     4800

ccaagatagt taagtggggt aagtcttaca ttcttttgta agctgctgaa agttgtgtat     4860

gagtagtcat atcataaagc tgctttgata taaaaaaggt ctatggccat actaccctga     4920

atgagtccca tcccatctga tataaacaat ctgcatattg ggattgtcag ggaatgttct     4980

taaagatcag attagtggca cctgctgaga tactgatgca cagcatggtt tctgaaccag     5040

tagtttccct gcagttgagc agggagcagc agcagcactt gcacaaatac atatacactc     5100

ttaacacttc ttacctactg gcttcctcta gcttttgtgg cagcttcagg tatatttagc     5160

actgaacgaa catctcaaga aggtataggc ctttgtttgt aagtcctgct gtcctagcat     5220

cctataatcc tggacttctc cagtactttc tggctggatt ggtatctgag gctagtagga     5280

agggcttgtt cctgctgggt agctctaaac aatgtattca tgggtaggaa cagcagccta     5340

ttctgccagc cttatttcta accattttag acatttgtta gtacatggta ttttaaaagt     5400

aaaacttaat gtcttccttt tttttctcca ctgtcttttt catagatcga gacatgtaag     5460

cagcatcatg gaggtaagtt tttgaccttg agaaaatgtt tttgtttcac tgtcctgagg     5520

actatttata gacagctcta acatgataac cctcactatg tggagaacat tgacagagta     5580

acattttagc agaggctagg tggaggctca gtgatgataa gtctgcgatg gtggatgcat     5640

gtgtcatggt catagctgtt tcctgtgtga aattgttatc cgctcagagg gcacaatcct     5700

attccgcgct atccgacaat ctccaagaca ttaggtggag ttcagttcgg cgtatggcat     5760

atgtcgctgg aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg     5820

ccgcgttgct ggcgtttttc cataggctcc gcccccctga cgagcatcac aaaaatcgac     5880

gctcaagtca gaggtggcga aacccgacag gactataaag ataccaggcg tttccccctg     5940

gaagctccct cgtgcgctct cctgttccga ccctgccgct taccggatac ctgtccgcct     6000

ttctcccttc gggaagcgtg gcgctttctc atagctcacg ctgtaggtat ctcagttcgg     6060

tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct     6120

gcgccttatc cggtaactat cgtcttgagt ccaacccggt aagacacgac ttatcgccac     6180

tggcagcagc cactggtaac aggattagca gagcgaggta tgtaggcggt gctacagagt     6240

tcttgaagtg gtggcctaac tacggctaca ctagaagaac agtatttggt atctgcgctc     6300

tgctgaagcc agttaccttc ggaaaaagag ttggtagctc ttgatccggc aaacaaacca     6360

ccgctggtag cggtggtttt tttgtttgca agcagcagat tacgcgcaga aaaaaaggat     6420

ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc tctattcaac aaagccgccg     6480

tcccgtcaag tcagcgtaaa tgggtagggg gcttcaaatc gtcctcgtga taccaattcg     6540

gagcctgctt ttttgtacaa acttgttgat aatggcaatt caaggatctt cacctagatc     6600

cttttaaatt aaaaatgaag ttttaaatca atctaaagta tatatgagta aacttggtct     6660

gacagttacc aatgcttaat cagtgaggca cctatctcag cgatctgtct atttcgttca     6720

tccatagttg cctgactccc cgtcgtgtag ataactacga tacgggaggg cttaccatct     6780

ggccccagtg ctgcaatgat accgcgagag ccacgctcac cggctccaga tttatcagca     6840

ataaaccagc cagccggaag ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc     6900

atccagtcta ttaattgttg ccgggaagct agagtaagta gttcgccagt taatagtttg     6960

cgcaacgttg ttgccattgc tacaggcatc gtggtgtcac gctcgtcgtt tggtatggct     7020

tcattcagct ccggttccca acgatcaagg cgagttacat gatcccccat gttgtgcaaa     7080

aaagcggtta gctccttcgg tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta     7140

tcactcatgg ttatggcagc actgcataat tctcttactg tcatgccatc cgtaagatgc     7200

ttttctgtga ctggtgagta ctcaaccaag tcattctgag aatagtgtat gcggcgaccg     7260

agttgctctt gcccggcgtc aatacgggat aataccgcgc cacatagcag aactttaaaa     7320

gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct caaggatctt accgctgttg     7380

agatccagtt cgatgtaacc cactcgtgca cccaactgat cttcagcatc ttttactttc     7440

accagcgttt ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg     7500

gcgacacgga aatgttgaat actcatactc ttcctttttc aatattattg aagcatttat     7560

cagggttatt gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata     7620

ggggttccgc gcacatttcc ccgaaaagtg ccagatacct gaaacaaaac ccatcgtacg     7680

gccaaggaag tctccaataa ctgtgatcca ccacaagcgc cagggttttc ccagtcacga     7740

cgttgtaaaa cgacggccag tcatgcataa tccgcacgca tctggaataa ggaagtgcca     7800

ttccgcctga cct                                                        7813


<210>  90
<211>  1205
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAVS1 targeting left homology arm

<400>  90
actctgcccc aggcctcctt accattcccc ttcgacctac tctcttccgc attggagtcg       60

ctttaactgg ccctggcttt ggcagcctgt gctgacccat gcagtcctcc ttaccatccc      120

tccctcgact tcccctcttc cgatgttgag cccctccagc cggtcctgga ctttgtctcc      180

ttccctgccc tgccctctcc tgaacctgag ccagctccca tagctcagtc tggtctatct      240

gcctggccct ggccattgtc actttgcgct gccctcctct cgcccccgag tgcccttgct      300

gtgccgccgg aactctgccc tctaacgctg ccgtctctct cctgagtccg gaccactttg      360

agctctactg gcttctgcgc cgcctctggc ccactgtttc cccttcccag gcaggtcctg      420

ctttctctga cctgcattct ctcccctggg cctgtgccgc tttctgtctg cagcttgtgg      480

cctgggtcac ctctacggct ggcccagatc cttccctgcc gcctccttca ggttccgtct      540

tcctccactc cctcttcccc ttgctctctg ctgtgttgct gcccaaggat gctctttccg      600

gagcacttcc ttctcggcgc tgcaccacgt gatgtcctct gagcggatcc tccccgtgtc      660

tgggtcctct ccgggcatct ctcctccctc acccaacccc atgccgtctt cactcgctgg      720

gttccctttt ccttctcctt ctggggcctg tgccatctct cgtttcttag gatggccttc      780

tccgacggat gtctcccttg cgtcccgcct ccccttcttg taggcctgca tcatcaccgt      840

ttttctggac aaccccaaag taccccgtct ccctggcttt agccacctct ccatcctctt      900

gctttctttg cctggacacc ccgttctcct gtggattcgg gtcacctctc actcctttca      960

tttgggcagc tcccctaccc cccttacctc tctagtctgt gctagctctt ccagccccct     1020

gtcatggcat cttccagggg tccgagagct cagctagtct tcttcctcca acccgggccc     1080

ctatgtccac ttcaggacag catgtttgct gcctccaggg atcctgtgtc cccgagctgg     1140

gaccacctta tattcccagg gccggttaat gtggctctgg ttctgggtac ttttatctgt     1200

cccct                                                                 1205


<210>  91
<211>  1200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAVS1 targeting right homology arm

<400>  91
ccaccccaca gtggggccac tagggacagg attggtgaca gaaaagcccc atccttaggc       60

ctcctccttc ctagtctcct gatattgggt ctaaccccca cctcctgtta ggcagattcc      120

ttatctggtg acacaccccc atttcctgga gccatctctc tccttgccag aacctctaag      180

gtttgcttac gatggagcca gagaggatcc tgggagggag agcttggcag ggggtgggag      240

ggaagggggg gatgcgtgac ctgcccggtt ctcagtggcc accctgcgct accctctccc      300

agaacctgag ctgctctgac gcggccgtct ggtgcgtttc actgatcctg gtgctgcagc      360

ttccttacac ttcccaagag gagaagcagt ttggaaaaac aaaatcagaa taagttggtc      420

ctgagttcta actttggctc ttcacctttc tagtccccaa tttatattgt tcctccgtgc      480

gtcagtttta cctgtgagat aaggccagta gccagccccg tcctggcagg gctgtggtga      540

ggaggggggt gtccgtgtgg aaaactccct ttgtgagaat ggtgcgtcct aggtgttcac      600

caggtcgtgg ccgcctctac tccctttctc tttctccatc cttctttcct taaagagtcc      660

ccagtgctat ctgggacata ttcctccgcc cagagcaggg tcccgcttcc ctaaggccct      720

gctctgggct tctgggtttg agtccttggc aagcccagga gaggcgctca ggcttccctg      780

tcccccttcc tcgtccacca tctcatgccc ctggctctcc tgccccttcc ctacaggggt      840

tcctggctct gctcttcaga ctgagccccg ttcccctgca tccccgtacc cctgcatccc      900

ccttcccctg catcccccag aggccccagg ccacctactt ggcctggacc ccacgagagg      960

ccaccccagc cctgtctacc aggctgcctt ttgggtggat tctcctccaa ctgtggggtg     1020

actgcttggc aaactcactc ttcggggtat cccaggaggc ctggagcatt ggggtgggct     1080

ggggttcaga gaggagggat tcccttctca ggttacgtgg ccaagaagca ggggagctgg     1140

gtttgggtca ggtctgggtg tggggtgacc agcttatgct gtttgcccag gacagcctag     1200


<210>  92
<211>  7971
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAVS1 Targeting plasmid

<400>  92
actctgcccc aggcctcctt accattcccc ttcgacctac tctcttccgc attggagtcg       60

ctttaactgg ccctggcttt ggcagcctgt gctgacccat gcagtcctcc ttaccatccc      120

tccctcgact tcccctcttc cgatgttgag cccctccagc cggtcctgga ctttgtctcc      180

ttccctgccc tgccctctcc tgaacctgag ccagctccca tagctcagtc tggtctatct      240

gcctggccct ggccattgtc actttgcgct gccctcctct cgcccccgag tgcccttgct      300

gtgccgccgg aactctgccc tctaacgctg ccgtctctct cctgagtccg gaccactttg      360

agctctactg gcttctgcgc cgcctctggc ccactgtttc cccttcccag gcaggtcctg      420

ctttctctga cctgcattct ctcccctggg cctgtgccgc tttctgtctg cagcttgtgg      480

cctgggtcac ctctacggct ggcccagatc cttccctgcc gcctccttca ggttccgtct      540

tcctccactc cctcttcccc ttgctctctg ctgtgttgct gcccaaggat gctctttccg      600

gagcacttcc ttctcggcgc tgcaccacgt gatgtcctct gagcggatcc tccccgtgtc      660

tgggtcctct ccgggcatct ctcctccctc acccaacccc atgccgtctt cactcgctgg      720

gttccctttt ccttctcctt ctggggcctg tgccatctct cgtttcttag gatggccttc      780

tccgacggat gtctcccttg cgtcccgcct ccccttcttg taggcctgca tcatcaccgt      840

ttttctggac aaccccaaag taccccgtct ccctggcttt agccacctct ccatcctctt      900

gctttctttg cctggacacc ccgttctcct gtggattcgg gtcacctctc actcctttca      960

tttgggcagc tcccctaccc cccttacctc tctagtctgt gctagctctt ccagccccct     1020

gtcatggcat cttccagggg tccgagagct cagctagtct tcttcctcca acccgggccc     1080

ctatgtccac ttcaggacag catgtttgct gcctccaggg atcctgtgtc cccgagctgg     1140

gaccacctta tattcccagg gccggttaat gtggctctgg ttctgggtac ttttatctgt     1200

cccctgcggc cgcacgcgta gatctattga ttattgacta gttattaata gtaatcaatt     1260

acggggtcat tagttcatag cccatatatg gagttccgcg ttacataact tacggtaaat     1320

ggcccgcctg gctgaccgcc caacgacccc cgcccattga cgtcaataat gacgtatgtt     1380

cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggacta tttacggtaa     1440

actgcccact tggcagtaca tcaagtgtat catatgccaa gtacgccccc tattgacgtc     1500

aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttatg ggactttcct     1560

acttggcagt acatctacgt attagtcatc gctattacca tgggtcgagg tgagccccac     1620

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat     1680

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggcgcgcg ccaggcgggg     1740

cggggcgggg cgaggggcgg ggcggggcga ggcggagagg tgcggcggca gccaatcaga     1800

gcggcgcgct ccgaaagttt ccttttatgg cgaggcggcg gcggcggcgg ccctataaaa     1860

agcgaagcgc gcggcgggcg ggagtcgctg cgttgccttc gccccgtgcc ccgctccgcg     1920

ccgcctcgcg ccgcccgccc cggctctgac tgaccgcgtt actcccacag gtgagcgggc     1980

gggacggccc ttctcctccg ggctgtaatt agcgcttggt ttaatgacgg ctcgtttctt     2040

ttctgtggct gcgtgaaagc cttaaagggc tccgggaggg ccctttgtgc gggggggagc     2100

ggctcggggg gtgcgtgcgt gtgtgtgtgc gtggggagcg ccgcgtgcgg cccgcgctgc     2160

ccggcggctg tgagcgctgc gggcgcggcg cggggctttg tgcgctccgc gtgtgcgcga     2220

ggggagcgcg gccgggggcg gtgccccgcg gtgcgggggg gctgcgaggg gaacaaaggc     2280

tgcgtgcggg gtgtgtgcgt gggggggtga gcagggggtg tgggcgcggc ggtcgggctg     2340

taaccccccc ctgcaccccc ctccccgagt tgctgagcac ggcccggctt cgggtgcggg     2400

gctccgtgcg gggcgtggcg cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg     2460

ggtgccgggc ggggcggggc cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg     2520

ccccggagcg ccggcggctg tcgaggcgcg gcgagccgca gccattgcct tttatggtaa     2580

tcgtgcgaga gggcgcaggg acttcctttg tcccaaatct ggcggagccg aaatctggga     2640

ggcgccgccg caccccctct agcgggcgcg ggcgaagcgg tgcggcgccg gcaggaagga     2700

aatgggcggg gagggccttc gtgcgtcgcc gcgccgccgt ccccttctcc atctccagcc     2760

tcggggctgc cgcaggggga cggctgcctt cgggggggac ggggcagggc ggggttcggc     2820

ttctggcgtg tgaccggcgg gatatctacg aagcggccgc cctctgctaa ccatgttcat     2880

gccttcttct ttttcctaca gctcctgggc aacgtgctgg ttattgtgct gtctcatcat     2940

tttggcaaag tcgacgccac catgctgctg ctggtcacat ctctgctgct gtgcgagctg     3000

ccccatcctg cctttctgct gatccccgac atccagatga cccagaccac aagcagcctg     3060

tctgccagcc tgggcgatag agtgaccatc agctgtagag ccagccagga catcagcaag     3120

tacctgaact ggtatcagca aaagcccgac ggcaccgtga agctgctgat ctaccacacc     3180

agcagactgc acagcggcgt gccaagcaga ttttctggca gcggctctgg caccgactac     3240

agcctgacaa tcagcaacct ggaacaagag gatatcgcta cctacttctg ccagcaaggc     3300

aacaccctgc cttacacctt tggcggaggc accaagctgg aaatcaccgg ctctacaagc     3360

ggcagcggca aacctggatc tggcgaggga tctaccaagg gcgaagtgaa actgcaagag     3420

tctggccctg gactggtggc cccatctcag tctctgagcg tgacctgtac agtcagcgga     3480

gtgtccctgc ctgattacgg cgtgtcctgg atcagacagc ctcctcggaa aggcctggaa     3540

tggctgggag tgatctgggg cagcgagaca acctactaca acagcgccct gaagtcccgg     3600

ctgaccatca tcaaggacaa ctccaagagc caggtgttcc tgaagatgaa cagcctgcag     3660

accgacgaca ccgccatcta ctattgcgcc aagcactact actacggcgg cagctacgcc     3720

atggattatt ggggccaggg caccagcgtg accgtgtcta gcacgacgac tcctgctcca     3780

aggcctccta cacctgcacc aaccattgca agtcagccgt tgagcctccg gccagaagca     3840

tgtcgcccag ccgcaggcgg ggctgtacac acgagaggct tggatttcgc atgtgacatc     3900

tatatctggg ccccactggc cggcacctgc ggcgtgctgc tgctgagcct ggtgatcacc     3960

aagcgaggcc gcaaaaaact cctttatata ttcaagcaac cttttatgag gcccgtccag     4020

accacgcaag aggaagatgg gtgctcttgc cgctttccag aggaagagga ggggggctgc     4080

gaacttagag tgaagttcag cagatccgcc gatgctcccg cctatcagca gggccaaaac     4140

cagctgtaca acgagctgaa cctggggaga agagaagagt acgacgtgct ggacaagcgg     4200

agaggcagag atcctgaaat gggcggcaag cccagacgga agaatcctca agagggcctg     4260

tataatgagc tgcagaaaga caagatggcc gaggcctaca gcgagatcgg aatgaagggc     4320

gagcgcagaa gaggcaaggg acacgatgga ctgtaccagg gcctgagcac cgccaccaag     4380

gatacctatg atgccctgca catgcaggcc ctgcctccaa gataataaaa cttgtttatt     4440

gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt     4500

ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta ccaccccaca     4560

gtggggccac tagggacagg attggtgaca gaaaagcccc atccttaggc ctcctccttc     4620

ctagtctcct gatattgggt ctaaccccca cctcctgtta ggcagattcc ttatctggtg     4680

acacaccccc atttcctgga gccatctctc tccttgccag aacctctaag gtttgcttac     4740

gatggagcca gagaggatcc tgggagggag agcttggcag ggggtgggag ggaagggggg     4800

gatgcgtgac ctgcccggtt ctcagtggcc accctgcgct accctctccc agaacctgag     4860

ctgctctgac gcggccgtct ggtgcgtttc actgatcctg gtgctgcagc ttccttacac     4920

ttcccaagag gagaagcagt ttggaaaaac aaaatcagaa taagttggtc ctgagttcta     4980

actttggctc ttcacctttc tagtccccaa tttatattgt tcctccgtgc gtcagtttta     5040

cctgtgagat aaggccagta gccagccccg tcctggcagg gctgtggtga ggaggggggt     5100

gtccgtgtgg aaaactccct ttgtgagaat ggtgcgtcct aggtgttcac caggtcgtgg     5160

ccgcctctac tccctttctc tttctccatc cttctttcct taaagagtcc ccagtgctat     5220

ctgggacata ttcctccgcc cagagcaggg tcccgcttcc ctaaggccct gctctgggct     5280

tctgggtttg agtccttggc aagcccagga gaggcgctca ggcttccctg tcccccttcc     5340

tcgtccacca tctcatgccc ctggctctcc tgccccttcc ctacaggggt tcctggctct     5400

gctcttcaga ctgagccccg ttcccctgca tccccgtacc cctgcatccc ccttcccctg     5460

catcccccag aggccccagg ccacctactt ggcctggacc ccacgagagg ccaccccagc     5520

cctgtctacc aggctgcctt ttgggtggat tctcctccaa ctgtggggtg actgcttggc     5580

aaactcactc ttcggggtat cccaggaggc ctggagcatt ggggtgggct ggggttcaga     5640

gaggagggat tcccttctca ggttacgtgg ccaagaagca ggggagctgg gtttgggtca     5700

ggtctgggtg tggggtgacc agcttatgct gtttgcccag gacagcctag aggctaggtg     5760

gaggctcagt gatgataagt ctgcgatggt ggatgcatgt gtcatggtca tagctgtttc     5820

ctgtgtgaaa ttgttatccg ctcagagggc acaatcctat tccgcgctat ccgacaatct     5880

ccaagacatt aggtggagtt cagttcggcg tatggcatat gtcgctggaa agaacatgtg     5940

agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca     6000

taggctccgc ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa     6060

cccgacagga ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc     6120

tgttccgacc ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc     6180

gctttctcat agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct     6240

gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg     6300

tcttgagtcc aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag     6360

gattagcaga gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta     6420

cggctacact agaagaacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg     6480

aaaaagagtt ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt     6540

tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt     6600

ttctacgggg tctgacgctc tattcaacaa agccgccgtc ccgtcaagtc agcgtaaatg     6660

ggtagggggc ttcaaatcgt cctcgtgata ccaattcgga gcctgctttt ttgtacaaac     6720

ttgttgataa tggcaattca aggatcttca cctagatcct tttaaattaa aaatgaagtt     6780

ttaaatcaat ctaaagtata tatgagtaaa cttggtctga cagttaccaa tgcttaatca     6840

gtgaggcacc tatctcagcg atctgtctat ttcgttcatc catagttgcc tgactccccg     6900

tcgtgtagat aactacgata cgggagggct taccatctgg ccccagtgct gcaatgatac     6960

cgcgagagcc acgctcaccg gctccagatt tatcagcaat aaaccagcca gccggaaggg     7020

ccgagcgcag aagtggtcct gcaactttat ccgcctccat ccagtctatt aattgttgcc     7080

gggaagctag agtaagtagt tcgccagtta atagtttgcg caacgttgtt gccattgcta     7140

caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc ggttcccaac     7200

gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa agcggttagc tccttcggtc     7260

ctccgatcgt tgtcagaagt aagttggccg cagtgttatc actcatggtt atggcagcac     7320

tgcataattc tcttactgtc atgccatccg taagatgctt ttctgtgact ggtgagtact     7380

caaccaagtc attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa     7440

tacgggataa taccgcgcca catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt     7500

cttcggggcg aaaactctca aggatcttac cgctgttgag atccagttcg atgtaaccca     7560

ctcgtgcacc caactgatct tcagcatctt ttactttcac cagcgtttct gggtgagcaa     7620

aaacaggaag gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa tgttgaatac     7680

tcatactctt cctttttcaa tattattgaa gcatttatca gggttattgt ctcatgagcg     7740

gatacatatt tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc acatttcccc     7800

gaaaagtgcc agatacctga aacaaaaccc atcgtacggc caaggaagtc tccaataact     7860

gtgatccacc acaagcgcca gggttttccc agtcacgacg ttgtaaaacg acggccagtc     7920

atgcataatc cgcacgcatc tggaataagg aagtgccatt ccgcctgacc t              7971


<210>  93
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M target gRNA

<400>  93
tttactcacg tcatccagca gaga                                              24


<210>  94
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAVS1 target gRNA

<400>  94
tttatctgtc ccctccaccc caca                                              24


<210>  95
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CIITA target gRNA

<400>  95
tttaccttgg ggctctgaca ggta                                              24


